PAPADOPOULOS, V. 1 CURRICULUM VITAE Vassilios Papadopoulos DPharm, PhD, DSc (hon) is the Dean of the School of Pharmacy at the University of Southern California. He also holds the John Stauffer Dean’s Chair in Pharmaceutical Sciences and he is a professor of Pharmacology & Pharmaceutical Sciences at USC. A graduate of the School of Pharmacy of the University of Athens, Greece, Dr. Papadopoulos completed his PhD in Health and Life Science at the Université Pierre et Marie Curie in Paris. He continued as a post-doctoral researcher in France and Australia. In 1988, he joined the faculty of Georgetown University’s School of Medicine in Washington D.C. where he rose through the ranks to become professor and chair of Biochemistry and Molecular Biology. In 2004, Dr. Papadopoulos was appointed associate vice president for research and then director of the Biomedical Graduate Research Organization at Georgetown University Medical Centre. Dr. Papadopoulos served from 2007-2016 as the executive director and chief scientific officer of the Research Institute of the McGill University Health Centre (RI-MUHC), one of Canada’s largest research centres. At the RI-MUHC he was a professor in the Faculty of Medicine at McGill University and held a Canada Research Chair in Biochemical Pharmacology and the Phil Gold Chair in Medicine at McGill and the MUHC. Dr. Papadopoulos’ research focus is in the pathophysiology and treatment of diseases related to altered steroid hormone synthesis, including endocrine pathologies, male reproductive disorders, neuropathologies and cancer. His research has led to a better understanding of the pathways leading to steroid hormone synthesis, the pharmacology of steroid formation in the periphery and brain, the identification of new molecules targeting key elements in diseases where steroids play a determining role, and the development of diagnostics for these diseases. This work has been supported by grants and contracts from the National Institutes of Health, National Science Foundation, US Department of Defense, Canadian Institutes of Health Research, Canadian Foundation of Innovation, private foundations, and the pharmaceutical industry. He has published more than 300 articles and holds many patents. His work has been cited over 18,000 times. He is the recipient of numerous awards and an elected foreign member of the National Academy of Pharmacy and the National Academy of Medicine in France, a fellow of the American Association for the Advancement of Science in the United States and a fellow of the Canadian Academy of Health Sciences. Dr. Papadopoulos continues to supervise graduate and postgraduate students, serves on advisory committees of various U.S., Canadian, European and other government agencies, foundations and corporations, and is on the editorial boards of several scientific journals. He has served on the board of directors and advisory boards of biotechnology companies and as a consultant for the pharmaceutical industry. Dr. Papadopoulos serves on the board of directors of non-profit corporations whose mission is to support biomedical research and improve healthcare delivery. In addition to his scientific achievements, Dr. Papadopoulos also contributed and continues to contribute to the life of Universities and Academic Health Sciences Centers. As an administrator, Dr. Papadopoulos has worked on restructuring research within University Hospital and School environments and creating large scale research and infrastructure projects.
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PAPADOPOULOS, V.
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CURRICULUM VITAE
Vassilios Papadopoulos DPharm, PhD, DSc (hon) is the Dean of the School of Pharmacy at the University of Southern California. He also holds the John Stauffer Dean’s Chair in Pharmaceutical Sciences and he is a professor of Pharmacology & Pharmaceutical Sciences at USC. A graduate of the School of Pharmacy of the University of Athens, Greece, Dr. Papadopoulos completed his PhD in Health and Life Science at the Université
Pierre et Marie Curie in Paris. He continued as a post-doctoral researcher in France and Australia. In 1988, he joined the faculty of Georgetown University’s School of Medicine in Washington D.C. where he rose through the ranks to become professor and chair of Biochemistry and Molecular Biology. In 2004, Dr. Papadopoulos was appointed associate vice president for research and then director of the Biomedical Graduate Research Organization at Georgetown University Medical Centre. Dr. Papadopoulos served from 2007-2016 as the executive director and chief scientific officer of the Research Institute of the McGill University Health Centre (RI-MUHC), one of Canada’s largest research centres. At the RI-MUHC he was a professor in the Faculty of Medicine at McGill University and held a Canada Research Chair in Biochemical Pharmacology and the Phil Gold Chair in Medicine at McGill and the MUHC. Dr. Papadopoulos’ research focus is in the pathophysiology and treatment of diseases related to altered steroid hormone synthesis, including endocrine pathologies, male reproductive disorders, neuropathologies and cancer. His research has led to a better understanding of the pathways leading to steroid hormone synthesis, the pharmacology of steroid formation in the periphery and brain, the identification of new molecules targeting key elements in diseases where steroids play a determining role, and the development of diagnostics for these diseases. This work has been supported by grants and contracts from the National Institutes of Health, National Science Foundation, US Department of Defense, Canadian Institutes of Health Research, Canadian Foundation of Innovation, private foundations, and the pharmaceutical industry. He has published more than 300 articles and holds many patents. His work has been cited over 18,000 times. He is the recipient of numerous awards and an elected foreign member of the National Academy of Pharmacy and the National Academy of Medicine in France, a fellow of the American Association for the Advancement of Science in the United States and a fellow of the Canadian Academy of Health Sciences. Dr. Papadopoulos continues to supervise graduate and postgraduate students, serves on advisory committees of various U.S., Canadian, European and other government agencies, foundations and corporations, and is on the editorial boards of several scientific journals. He has served on the board of directors and advisory boards of biotechnology companies and as a consultant for the pharmaceutical industry. Dr. Papadopoulos serves on the board of directors of non-profit corporations whose mission is to support biomedical research and improve healthcare delivery. In addition to his scientific achievements, Dr. Papadopoulos also contributed and continues to contribute to the life of Universities and Academic Health Sciences Centers. As an administrator, Dr. Papadopoulos has worked on restructuring research within University Hospital and School environments and creating large scale research and infrastructure projects.
Title: Dean School of Pharmacy John Stauffer Dean’s Chair in Pharmaceutical Sciences University of Southern California
Professor Department of Pharmacology and Pharmaceutical Sciences School of Pharmacy University of Southern California
Date of Birth: February 18th, 1961
Place of Birth: Athens, Greece
Citizenship: U.S.A.; Greece; Permanent Resident of Canada
Family Status: Married to Martine G. Culty, Ph.D. Associate Professor Department of Pharmacology and Pharmaceutical Sciences School of Pharmacy University of Southern California Three children
Languages: Greek, English, French
Office Address: School of Pharmacy University of Southern California 1985 Zonal Avenue Los Angeles, California 90089-9121 Tel: 323-442-1379 Fax: 323-442-1681
Degree in Pharmacy with distinction, School of Pharmacy, Ethnikon and Kapodistriakon University of Athens (University of Athens), 104 Solonos Street, 10680 Athens, Greece (09/1978 - 07/1982). In 1984, the degree was recognized equivalent to terminal pharmacy degree in France (diplome d’état de Docteur en Pharmacie; Doctor in Pharmacy) by the Centre Hospitalier Universitaire de Caen, University of Caen, France.
Degree of Extensive Studies (diplome d’études approfondies-D.E.A.; M.Sc.) in Animal Biology and Physiology, University Pierre and Marie Curie (Paris VI), 4 Place Jussieu, 7525 Paris Cedex 05, Paris, France, with Professors R. Ozon and C. Thibault (09/1982 - 08/1983).
Doctorate Degree of Health and Life Sciences (Ph.D.) with distinction, University Pierre and Marie Curie (Paris VI), 4 Place Jussieu, 7525 Paris Cedex 05, Paris, France, with Professors R. Ozon and M.A. Drosdowsky (09/1983 - 05/1986).
Postdoctoral fellow, Department of Biochemistry, Faculty of Medicine, C.N.R.S., U.A.-609, (National Center of Scientific Research), Centre Hospitalier Universitaire, Av. Cote de Nacre, 14032 Caen Cedex, France, with Professor M.A. Drosdowsky (06/1986 - 12/1986).
Research Officer, Post-doctoral fellow, National Health and Medical Research Council (NHMRC), Department of Endocrinology, The Prince of Wales Hospital, The University of New South Wales, High and Avoca Streets, 2031 Randwick, New South Wales, Australia, with Professor P.F. Hall (01/1987 - 01/1988).
Senior Research Officer, Post-doctoral fellow, National Health and Medical Research Council (NHMRC), Department of Endocrinology, The Prince of Wales Hospital, The University of New South Wales, High and Avoca Streets, 2031 Randwick, New South Wales, Australia, with Professor P.F. Hall (02/1988 - 10/1988).
PROFESSIONAL EXPERIENCE:
Academia
Clinical Associate (Médecin/Pharmacien attaché), Department of Clinical Biochemistry, Centre Hospitalier Universitaire de Caen, Av. Cote de Nacre, 14032 Caen Cedex, France (07/1984 - 12/1986).
Research Officer, National Health and Medical Research Council (NHMRC), Department of Endocrinology, The Prince of Wales Hospital, The University of New South Wales, High and Avoca Streets, 2031 Randwick, New South Wales, Australia (01/1987 - 01/1988).
Senior Research Officer, National Health and Medical Research Council (NHMRC), Department of Endocrinology, The Prince of Wales Hospital, The University of New South Wales, High and Avoca Streets, 2031 Randwick, New South Wales, Australia (02/1988 - 10/1988).
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Research Assistant Professor, Department of Anatomy and Cell Biology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, D.C. 20007, USA (11/1988 - 12/1989).
Assistant Professor, Tenure track, Department of Cell Biology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, D.C. 20007, USA (01/1990 - 06/1995)
Special Volunteer, Laboratory of Cell Biology (Director: Dr. M.M. Gottesman), National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (01/94-07/94)
Member, Lombardi Cancer Center, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, D.C. 20007, USA (12/1994 – 06/2007)
Associate Professor, Tenured, Department of Cell Biology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, D.C. 20007, USA (07/1995 – 06/1998)
Associate Professor, secondary appointment, Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, D.C. 20007, USA (09/1996 – 06/1998)
Professor (Tenured), Department of Cell Biology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, D.C. 20007, USA (07/1998 – 06/2003)
Professor, secondary appointment, Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, D.C. 20007, USA (07/1998 - 06/2003)
Head, Division of Hormone Research, Departments of Cell Biology & Pharmacology, Georgetown University Medical Center (06/99-06/2003)
Member, Center for Neural Injury and Recovery, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, D.C. 20007, USA (10/1999 – 06/2007)
Professor, secondary appointment, Department of Neuroscience, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, D.C. 20007, USA (11/1999 - 06/2003)
Professor (Tenured) and Chair, Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, D.C. 20057, USA (07/2003 – 06/2005). In this position Dr. Papadopoulos successfuly reorganizad the Department which within two years moved in the ranks to the top Department at Georgetown both for its research and graduate programs.
Member, Center for the Brain Basis of Cognition, Georgetown University (2004-2007)
Associate Vice President for Research, Georgetown University Medical Center (10/04-06/05; 03/06-06/07). In this role, Dr. Papadopoulos worked closely with the Executive Vice President of the Medical Center and with the department chairs, institute and center directors and faculty researchers to strengthen the Georgetown University research programs and to help adapt them to take advantage of emerging opportunities. In addition to coordinating Georgetown's many diverse research efforts, Dr. Papadopoulos played a leadership role in the University’s efforts to restructure and reorganize the
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research component of the Medical Center. In this capacity, Dr. Papadopoulos also worked closely with leaders of Georgetown University Hospital and MedStar Health, a consortium of seven hospitals in the mid-Atlantic region, to enhance the clinical and translational research efforts between the two organizations. With the promotion to Director of the Biomedical Research Organization Dr. Papadopoulos step down from this position on June 2005. However, on February 2006 the Executive Vice President of the Medical Center asked Dr. Papadopoulos to reassume this role with the goal to better integrate research at the Medical Center with the Lombardi Comprehensive Cancer Center and represent the University at National and International Organizations and initiatives.
Director of Biomedical Graduate Research Organization (BGRO) (06/2005-06/2007) and Associate Vice President of Georgetown University Medical Center. In this role, Dr. Papadopoulos was responsible for managing the activities, planning, finances, personnel, space assignments and operations of BGRO, consistent with the mission of the institution, the institutional financial plan and the policies and procedures of Georgetown University Medical Center. It was his responsibility to oversee the research programs within BGRO and to foster new research and educational initiatives at the local and National levels. Moreover, as the Director of BGRO Dr. Papadopoulos also oversaw fundraising efforts to support various programs and increase the endowment and worked with various government agencies and legislatives bodies to advance the interests of Georgetown University. BGRO consisted of the Basic Sciences Departments (Biochemistry & Molecular Biology, Cell Biology, Microbiology & Immunology, Neuroscience, Pharmacology, Physiology & Biophysics), the basic and clinical research within the Clinical Departments (Anesthesia, Emergency Med, Family Medicine, Medicine, Neurology, Neurosurgery, Obstetrics and Gynecology, Ophthalmology, Orthopedic Surgery, Otolaryngology, Pediatrics, Physical Med & Rehab, Plastic Surgery, Psychiatry, Radiology, Surgery, Urology), the research institutes and centers at the Medical Center, and all the Graduate Programs (MS and PhD) of Georgetown University Medical Center. In this capacity, Dr. Papadopoulos also worked closely with leaders of Georgetown University Hospital and MedStar Health to enhance and integrate the clinical and translational research efforts between the two organizations, as well as take advantage of emerging opportunities. This role also included the integration of the research performed at the Medical Center with research at the Georgetown College and the McDonough School of Business.
Under Dr. Papadopoulos’ leadership the Institution obtained a NIH-funded General Clinical Research Center to support translational research. Moreover, he expanded the graduate (MSc) programs and established the first on-line graduate programs.
Professor (Adjunct), Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, D.C. 20057, USA (07/2007 – present)
Professor (Tenured), Department of Medicine, Faculty of Medicine, McGill University, Montreal General Hospital, 1650 Cedar Avenue, Room D6.237, Montreal, Quebec, H3G 1A4 Canada (07/2007 - present)
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Member, Division of Endocrinology and Metabolism, Department of Medicine, McGill University (07/2007 - present)
Member, Division of Expoerimental Medicine, Department of Medicine, McGill University (07/2007 - present)
Professor, secondary appointment (associate member), Department of Biochemistry, Faculty of Medicine, McGill University, McIntyre Medical Sciences Building, 3655 Promenade Sir William Osler, Montreal, Quebec, H3G 1Y6 Canada (07/2007-present)
Professor, secondary appointment (associate member), Department of Pharmacology & Therapeutics, Faculty of Medicine, McGill University, McIntyre Medical Sciences Building, 3655 Promenade Sir William Osler, Montreal, Quebec, H3G 1Y6 Canada (07/2007-present)
Medical Scientist, member of the Council of Physicians, Dentists and Pharmacists (CPDP), McGill University Health Centre, Montreal, Quebec, Canada (07/2007-10/2015)
Executive Director and Chief Scientific Officer of the Research Institute of the McGill University Health Center and Associate Executive Director for Research at McGill University Health Center (07/2007-06/2011; renewed 07/2011-06/2015; renewed for a third term 07/2015-06/2019).
As Executive Director and Chief Scientific Officer of the Research Institute of the MUHC, Dr. Papadopoulos’ oversees one of Canada’s largest hospital-based research institutes and ensures its management, development and research activities. The Research Institute of the MUHC (RI-MUHC) is a biomedical and health care hospital research center with faculty members in various hospitals and the University. The Institute is the research arm of the MUHC, a university health center affiliated with the Faculty of Medicine at McGill University. The RI-MUHC supports over 500 faculty members, nearly 1,200 graduate and post-doctoral trainees, over 2,000 staff, and operates more than 200 laboratories devoted to a broad spectrum of fundamental and clinical research. There are over 1,800 ongoing clinical trials at the RI-MUHC. The Institute is a non-for profit corporation overseen by a Board of Directors and offers full services for grants and contracts management, finances, legal, and business development. Since 2012 the annual budget of the Institute has been exceeding $175M, a number that does not include faculty/member salaries, the largest in its history.
The RI-MUHC Institute operates at the forefront of knowledge, innovation and technology and is inextricably linked to the clinical programs of the MUHC, ensuring that patients benefit directly from the latest research-based knowledge. The MUHC is a comprehensive academic health institution, a merger of five teaching hospitals affiliated with the Faculty of Medicine at McGill University — the Montreal Children's, Montreal General, Royal Victoria, and Montreal Neurological Hospitals, as well as the Montreal Chest Institute. In his role as Associate Executive Director for Research at MUHC, Dr. Papadopoulos co-ordinates translational research efforts across the hospital members of MUHC. Moreover, Dr. Papadopoulos oversees fundraising efforts to support various research programs within MUHC, deals with provincial and federal government bodies responsible for research, technology and innovation, interacts with the private sector and promotes commercialization of the research outcomes of the Institute.
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Dr. Papadopoulos’ belief is that we live in an ecosystem where a successful Montreal and Quebec will provide the best environment for the success of the Research Institute. Thus, he has been involved in promoting Montreal and Quebec through various local and government initiatives, participating in the management of various non-profit Quebec organizations and was invited by the Quebec government to be part of various missions around the world. Moreover, Dr. Papadopoulos was invited by the Quebec government to be part of the group designing Quebec’s Strategy for Research and Innovation by the Ministry of Economic Development, Innovation and Exports (2009) and more recently by the Ministry of Higher Education, Research, Science and Technology (2012).
Dr. Papadopoulos has also undertaken a number of international initiatives in an effort to establish the RI-MUHC as an international research hub for research training. These include exchanges and agreements with the government and Universities in the People’s Republic of China, Malaysia, the Kingdom of Saudi Arabia and the State of Kuwait.
Part of Dr. Papadopoulos’s efforts have been dedicated in restructuring and reorganizing research within the University Hospital environment while initiating large scale infrastructure and research projects. He successfully led such an initiative entitled “Translational Research and Intervention across the Lifespan” and obtained $100M from the Canadian Foundation of Innovation, $100M from the Quebec government and $50M from donations to build a new state-of-the-art facility coupled with integrated research themes to house fundamental, clinical and evaluative research at the RI-MUHC within and around the new MUHC hospital site at the total cost of $350M. Dr. Papadopoulos was part of the executive team that oversaw the development of the 3,000,000 sf. $1.5B MUHC integrated super-hospital and Research Institute at the Glen yards in Montreal. In addition to overseeing the development of the Institute’s new facilities and research programs, he is also planning the redevelopment of the research infrastructure and programs at the Montreal General Hospital of the MUHC. The research facilities were inaugurated on February 2015 and the hospital facilities on June 2015.
Member, Réseau Québécois en Reproduction, Fonds de recherche du Québec – Nature et technologies (2007-present)
Member, Centre for the Study of Reproduction, McGill University (2007-present)
Member, Consortium pour l'Identification précoce de la Maladie d'Alzheimer – Québec (2010-present)
Professor, secondary appointment (associate member), Department of Pathology, Faculty of Medicine, McGill University (10/2012-present)
Member, Réseau de Recherche sur la santé cardiometabolique, Fonds de recherche du Québec – Santé (2012-present)
Senior Scientist, Experimental Therapeutics and Metabolism Program (Member) and Child Health and Human Development Program (Associate Member), Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada (11/2015-present)
Dean, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90089, USA (10/2016-present).
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Founded in 1905, the University of Southern California (USC) School of Pharmacy has played a key leadership role in both the advancement of the field of pharmacy and in the education of new generations of pharmacists, and remains one of the nation’s foremost schools of pharmacy today. As the needs of society and the profession changed, the School has responded by pioneering new programs to prepare future pharmacists for an expanded role in the health care profession. USC developed the nation’s first Doctor of Pharmacy degree in 1950 and is among the first schools of pharmacy to establish a clinical curriculum, beginning in 1968. Those were radical advances at the time but are now considered the foundation of training for all pharmacists throughout the US. More recently, the School has developed innovative programs in regulatory science including development of the first doctoral program in Regulatory Science in the International Center for Regulatory Sciences, and health economics and policy including the USC Leonard D. Schaeffer Center for Health Policy & Economics, which spans the School of Pharmacy and the Price School of Public Policy. In 2012, the School of Pharmacy received one of 102 Health Care Innovation awards for $12 million dollars to evaluate the integral role of pharmacists in health care. The School has over 700 students in its professional degree program, 300 in its graduate program, and has more than 80 full-time faculty members. The School ranks ninth among all pharmacy schools and the top private school by US News and World Report 2016.
In this new position Dr. Papadopoulos brings a strong entrepreneurial vision, grounded in scholarly accomplishment and public leadership, with demonstrated experience in building partnerships that will maximize the School’s intellectual resources. With vision and strategy, the Dean works with faculty, colleagues, key stakeholders and partners to continue to build for the future. The School has remarkable strengths including national leadership in pharmacy science, clinical and policy issues and patient care; influential research on the regulatory environment and its policy implications; and leading research on the economics of the pharmaceutical industry, drug development and the contributions of pharmacy to healthcare.
Professor (tenured), Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California 1985 Zonal Avenue, Los Angeles, California 90089, USA (10/2016-present)
Industry & Healthcare
Consultant, Institute Henri Beaufour-IPSEN, Paris, France (1996-1999)
Consultant, TreviGen Inc., Gaithersburg, MD, USA (1998-2003)
Consultant, Elan Pharmaceuticals Inc., San Francisco, CA, USA (1998-1999)
Consultant, Sebiopharm Inc., Paris, France (1999-2001)
Senior Scientific Advisor, Samaritan Pharmaceuticals, Inc., Las Vegas, NV, USA (2000-2007)
Member, Board of Directors, Samaritan Pharmaceuticals, Inc., Las Vegas, NV, USA (2000-2005)
Consultant, Fusion Capital Partners, Chicago, IL, USA (2002-2004)
Consultant, ONO Pharmaceuticals, Osaka, Japan (2015-2016)
Scientific Founder, IASO Biomed Inc., Centennial, CO, USA (2015-present)
Member, Board of Directors and Chair Scientific Advisor Board, IASO Biomed, Inc. Centennial, CO, USA (2015-present)
Consultant, Partners HealthCare System, Inc., Massachussets General Hospital, A. A. Martinos Center for Biomedical Imaging; NIH-funded TSPO imaging studies; PI: Dr. Marco Loggia (2016-present)
Non-profit Organizations (Board of Directors & International Advisory Boards)
Member (Associate), Board of Directors of the Federation of the Association of the Societies for Experimental Biology (FASEB), Washington, DC, USA (2003-2005)
Member, Board of Directors of Pediatrics, Washington DC, USA (2005-2008)
Member, Executive Leadership Group of Vice-Presidents for Research, Association of Academic Health Centers, Washington, DC, USA (2006-2009)
Member, Council, American Society of Andrology (ASA). ASA has over 775 members from all over the world whose specialty fields includes male reproduction, endocrinology, urology, anatomy, gynecology/obstetrics, biochemistry, animal science, molecular & cell biology, and reproductive technologies. ASA is a unique partnership of scientists and clinicians. Chicago, IL, USA (2008-2011)
Member, Board of Directors and Member, Executive Committee, Montreal In Vivo, Montreal's Life Sciences cluster, a complete ensemble of over 400 private companies and 150 public and university-based research organizations. Montréal, Québec, Canada (2007-2016).
Member, Board of Directors and Member, Executive Committee, Centre Québécois sur la Découverte du Médicament (CQDM). The Quebec Consortium for Drug Discovery is an innovative public-private partnership model, whose principal mission is to fund research projects carried out in partnership between the academic and hospital milieus in the public sector and the pharmaceutical and biotechnology industries in the private sector. Montreal, Quebec, Canada (2008-present).
Member, Board of Directors, Centre Québécois de Valorisation des Biotechnologies (CQVB), a liaison and transfer center that aims to stimulate and support technology transfer and innovation within small to medium-size bio-industry companies in Quebec. Quebec City, Canada (2009-2015)
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Member, Scientific Advisory Committee, School of Biomedical Sciences and Faculty of Medicine, Chinese University of Hong Kong, Hong Kong (2009-2014)
Member, Board of Directors, The Board of Trade of Metropolitan Montreal. The Board of Trade represents the business community of the Greater Montreal and is involved in economic development of the city and all aspects of the economic growth and prosperity of the people of Montreal. Canada (2011-2012)
Member, Board of Directors, Fonds de la Recherche du Québec - Santé (FRQS). FRQS is the Quebec government funding agency charged to implement government strategy with respect to human health research. FRQS supports basic, clinical, epidemiological, public health, health services and the social determinants of health research in Quebec. Montreal, Quebec, Canada (2011-2016)
Member, National Scientific Advisory Council, American Federation for Aging Research. New York, NY, USA (2012-present)
Co-Chair, Committee of Vice-Presidents of Health Research, Association of Canadian Academic Healthcare Organizations. Ottawa, Ontario, Canada (2011-2014)
Member, Institute Advisory Board, CIHR Institute of Human Development, Child and Youth Health, Ottawa, Ontario, Canada (2013-2016)
Member, Board of Directors, and Co-Chair, Committee of Vice-Presidents of Health Research, HealthCareCAN. The Canadian Healthcare Association and the Association of Canadian Academic Healthcare Organizations merged on January 1, 2014. HealthCareCAN is the national voice and champion of innovative health organizations across the continuum of care. HealthCareCAN’s focus is to advance an integrated, sustainable and accountable health system that provides Canadians with world-leading health services and to improve the health of Canadians through an evidence-based and innovative health system. Ottawa, Ontario, Canada (2014-2017)
Member, Council, American Society of Andrology (ASA), Chicago, IL, USA (2014-2017)
Chair, Scientific Advisory Committee, School of Biomedical Sciences and Faculty of Medicine, Chinese University of Hong Kong, Hong Kong (2015-2018)
Member, Board of Dircetors ALIGO Inc, a university research commercialization company. ALIGO helps bring discoveries and developing technologies fom the academic realm into the usness world. Montreal, Canada (2015-2016)
President, American Society of Andrology (ASA), Chicago, IL, USA (2015-2016)
Member, Board of Directors, McPeak-Sirois Foundation. The Foundation supports clinical research in breast cancer. Montreal, Quebec, Canada (2016).
Member, ex-officio, Advisory Board, USC Schaeffer Center for Health Policy & Economics (2016-present)
AWARDS & HONORS:
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Gold Medal Award from the City of Athens, Greece (1978)
Sandoz Award, Endocrine Society of Australia (1988)
James Shannon Director’s Award from NIDDK, NIH, USA (1991-1993)
Research Career Development Award, NICHD, NIH, USA (1993-1998)
Elected Corresponding Member of the French National Academy of Pharmacy; pharmacological sciences section (2002). This honor was given in recognition of studies assigning a physiological function to a drug-binding site, the peripheral-type benzodiazepine receptor/ translocator protein and the work on the pharmacological regulation of steroid biosynthesis.
Biotechnology Leadership Award, Georgetown University (2004).
EVOL (Education & Volunteers) Visionary Leadership Award, Georgetown University, for the support of educational programs for minority high school students at the Washington, DC area (2007)
Canada Research Chair (tier 1) in Biochemical Pharmacology (2007-2021). The Chair was awarded for research in the discipline of Drugs- Pharmaceutical Science, Chemistry, and non-medical use of drugs.
Elected Corresponding Member of the French National Academy of Medicine; biological and pharmaceutical sciences section (2008). This honor was given in recognition of scientific achievements in the biomedical field.
Larry Ewing Lecture in Reproductive Biology; Johns Hopkins University School of Public Health; Cholesterol transport in steroidogenic cells: mechanisms and function in health and disease. (2008)
Dean’s Distinguished Lecture; Georgetown University Medical Center; Cholesterol transport in steroidogenic cells: mechanisms and function in health and disease. (2009)
Elected Fellow of the American Association for the Advancement of Science (AAAS), Section on Medical Sciences (2009). This honor was given in recognition of Dr. Papadopoulos’ contributions to Science and Technology.
Dr. Phil Gold Chair in Medicine supported by a McGill-MUHC endowment (2010) in recognition of Dr. Papadopoulos’ contributions to science and MUHC and McGill University.
Hellenic Medical Association of Quebec Award (2010).
Elected Fellow of the Canadian Academy of Health Sciences (CAHS) (2011) on the basis of demonstrated leadership, creativity, distinctive competencies and commitment to advance academic health sciences.
Awarded Fellow of The International College of Neuropsychopharmacology (2011) status in recognition of his achievements in neuropsychopharmacology.
Prize Michel Sarrazin awarded by the Club de recherches cliniques du Quebec in recognition of Dr. Papadopoulos’ contributions to biomedical research (2013). The Prize is
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awarded annually to a celebrated Quebec scientist whom, through their dynamism and productivity, has made a significant contribution to the advancement of biomedical research. It is named in honour of Michel Sarrazin (1659–1734) who was the first Canadian scientist.
DEKA award from the Hellenic Board of Trade (2014). DEKA Awards recognize outstanding individuals, businesses and organizations of Greek origin in the Greater Montreal area, who through their creativity and excellence, have contributed to the enrichment of the business community.
President, American Society of Andrology, USA (2015-16).
Doctor of Science Honoris Causa, University of Rouen, Rouen, France (2016).
John Stauffer Dean’s Chair in Pharmaceutical Sciences, University of Southern California (2016).
Presented with lifelong membership of Rho Chi Society, Academic honor society for the profession of Pharmacy, USA (2017)
Elected to the University of Southern California Chapter of the National Academy of Inventors, USA (2017)
Highlights and recognitions:
Dr. Papadopoulos was nominated for the Golden Apple Award for excellence in teaching (1999, 2000 and 2001).
Dr. Papadopoulos was nominated for the Geza M. Illes Award for excellence in Gross Anatomy teaching (2001 and 2002).
The paper by Culty M, Luo L, Yao Z, Chen H Papadopoulos V, Zirkin B (2002) Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells, Journal of Andrology, 23:439-447, was accompanied by an editorial commentaries published in Journal of Andrology, 23:326-327; ibid 327-328.
The paper by Yao Z, Papadopoulos V (2002) Function of ß-amyloid in cholesterol homeostasis: a lead to neurotoxicity, FASEB Journal, 16:1677-1679, made the cover of FASEB Journal, the October 2002, volume 16, number 12 issue.
The paper by Han Z, Slack SR, Li W, Papadopoulos V (2003) Expression of peripheral benzodiazepine receptor (PBR) in human tumors: relationship to breast, colon and prostate tumor progression, Journal of Receptor Research and Signal Transduction, 23:225-238, was featured in the December 5 issue of LeadDiscovery as being of special interest to the pharmaceutical industry and biotechnology sectors and was selected for editorial coverage by Therapeutic Advances.
The 2004 Galien prize (France) for innovation in pharmaceutical research was awarded to IPSEN-Beaufour Corporation, Paris, France. In awarding this prize the jury cited the
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work performed under contract in Dr. Papadopoulos’ laboratory on the mechanism of action underlying the neuroprotective properties of the Ginkgo biloba extract EGb 761 and isolated ginkgolides.
The paper by Lecanu L, Yao W, Teper GL, Yao ZX, Greeson J, Papadopoulos V (2004) Identification of naturally occurring 22R-hydroxycholesterol derivatives preventing -amyloid-induced neurotoxicity, Steroids, 69:1-16. was featured in the January 25 issue of LeadDiscovery as being of special interest to the pharmaceutical industry and biotechnology sectors.
The paper by Yao Z-X, Han Z, Drieu K, Papadopoulos V (2004) Ginkgo biloba extract (EGb 761) inhibits β-amyloid production by lowering free cholesterol levels. Journal of Nutritional Biochemistry, 15:745-752, was featured in the Neurobiology of Lipids 'Noteworthy' section alerting interested readers about selected noteworthy original research (not review) articles on the subject of the Neurobiology of Lipids scope.
The paper by Lecanu L, Yao W, Piechot A, Greeson J, Tzalis D, Papadopoulos V (2005) Identification, design, synthesis, and pharmacological activity of (4-ethyl-piperaz-1-yl)-phenylmethanone derivatives with neuroprotective properties against β-amyloid-induced toxicity, Neuropharmacology, 49:86-96, was featured on October 3 in LeadDiscovery as being of especial interest to the pharmaceutical industry and biotechnology sectors.
The paper by Liu Y, Yao ZX, Papadopoulos V (2005) Cytochrome P450 17α hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase activity associated with CYP17 in Leydig cells, Molecular Endocrinology, 19:1918-1931, was featured in the Endocrine News magazine published by the Endocrine Society.
The paper by Liu Y, Yao Z, Bendavid C, Borgmeyer C, Han Z, Cavalli LR, Chan W-Y, Folmer J, Zirkin BR, Haddad BR, Gallicano GI, Papadopoulos V (2005) Haploinsufficiency of cytochrome P450 17α-hydroxylase/17,20 lyase (CYP17) causes infertility in male mice, Molecular Endocrinology, 19:2380-2389, was featured in the Endocrine News magazine published by the Endocrine Society.
The 2006 North American Technology Innovation Award was awarded by the Frost & Sullivan Best Practices Group to Samaritan Pharmaceuticals Inc. and Samaritan PharmaPlaz Ireland, Inc., for the development of a novel-therapy solution targeting HIV. The concept underlying the mechanism of action of this drug, as well as its development, was performed under contract in Dr. Papadopoulos’ laboratory.
The paper by Papadopoulos V, Lecanu L, Brown, RC, Han Z, Yao ZX (2006) Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders, Neuroscience, 138:749-756, was featured in LeadDiscovery as being of special interest to the pharmaceutical industry and biotechnology sectors.
The paper by Li W, Hardwick M, Rosenthal DR, Culty M, Papadopoulos V (2007) Peripheral-type benzodiazepine receptor overexpression and knockdown in human breast cancer cells indicate its prominent role in tumor cell proliferation, Biochemical Pharmacology,73:491-503, was featured in the December 19 issue of LeadDiscovery as being of special interest to the pharmaceutical industry and biotechnology sectors.
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The paper by Liu Y, Dettin L, Folmer J, Zirkin BR, Papadopoulos V (2007) Abnormal morphology of spermatozoa in cytochrome P450 17-hydroxylase/17,20-lyase (CYP17) deficient mice. Journal of Andrology, 28:453-460, made the cover of the Journal of Andrology, May 2007 issue.
Researcher of the Month; voted by the Canadians for Health Research organization (October 2007).
The paper by Martinez–Arguelles DB, Culty M, Zirkin BR, Papadopoulos V (2009) In utero exposure to di-(2-ethylhexyl) phthalate decreases mineralocorticoid receptor expression in the adult testis, Endocrinology, 150:5575-5585, was featured in the Endocrine News magazine published by the Endocrine Society.
The paper by Lecanu L, Tillement L, McCourty A, Yao W, Greeson J, Papadopoulos V (2010) Dimethyl-carbamic acid 2,3-bis-dimethylcarbamoyloxy-6-(4-ethyl-piperazine-1-carbonyl)-phenyl ester: a multi-target therapeutic approach to neuroprotection, Medicinal Chemistry, 6:123-140, was featured in the July 21, 2010, issue of LeadDiscovery as being of special interest to the pharmaceutical industry and biotechnology sectors.
The paper by Stanley E, Johnston D, Fan J, Papadopoulos V, Chen H, Ge R, Zirkin BR, Jelinsky S (2011) Stem Leydig cell differentiation: Gene expression during development of the adult population of Leydig cells, Biology of Reproduction, 85:1161-1166, was selected by the Faculty of 1000 (F1000), which placed the work at the top 2% of published articles in biology and medicine.
The paper entitled “A lead study on oxidative stress-mediated dehydroepiandrosterone formation in serum: the biochemical basis for a diagnosis of Alzheimer's disease” by Rammouz G, Lecanu L, Aisen P, Papadopoulos V published in the Journal of Alzheimer’s Disease, 2011; 24:5-16, was selected by Quebec Science magazine as one of the 10 best scientific discoveries of 2011 (February 2012).
Work from Dr. Papadopoulos’ laboratory on neurosteroids and Alzheimer’s disease was presented at the CBC/Radio-Canada program “Les années lumière” (2011).
The paper by Martinez–Arguelles DB, Campioli E, Lienhart C, Fan J, Culty M, Zirkin BR, Papadopoulos V (2014) entitled in utero exposure to the endocrine disruptor di-(2-ethylhexyl) phthalate induces long-term changes in gene expression in the adult male adrenal gland, Endocrinology, 155:1667-1678, was highlighted in the June 2014 French Endocrine Society Newsletter.
The paper by Aghazadeh Y, Martinez-Arguelles DB, Fan J, Culty M, Papadopoulos V (2014) Induction of androgen formation in the male by a TAT-VDAC1 fusion peptide blocking 14-3-3ε protein adaptor and mitochondrial VDAC1 interactions, Molecular Therapy (Nature), 22:1779-1791 was accompagned by an editorial commentary published in Molecular Therapy 22:1727-9.
Work from Dr. Papadopoulos’ laboratory on three-dimensional cell tomography was featured in the CBC/Radio-Canada Science Magazine “Decouverte” part of the program “Voyage au coeur de la cellule” broadcasted on Sunday October 19, 2014.
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The book edited by Tillement JP, Hauw JJ, and Papadopoulos V on “Vieillissement et démences: un défi médical, scientifique et socio-économique” was reviewed and recommended by Dr. JL Montastruc in an editorial published in Therapie, 70:239 (2015).
Work from Dr. Papadopoulos’ laboratory on environmental endocrine disrupting agents was featured in the Télé-Québec program “Une pilule, une petite granule” broadcasted on January 8, 2015.
The paper by Martinez–Arguelles D and Papadopoulos V (2015) Identification of hot spots of DNA methylation in the adult male adrenal in response to in utero exposure to the ubiquitous endocrine disruptor plasticizer di-(2-ethylhexyl) phthalate. Endocrinology, 156:124-133 was highlighted in the March 2015 French Endocrine Society Newsletter.
The paper by Martinez–Arguelles D and Papadopoulos V (2015) Mechanisms mediating environmental chemical-induced endocrine disruption in the adrenal gland. Frontiers in Endocrinology, 6:29 was highlighted with an editorial in Chemical Watch News.
The paper by Campioli E, Duong TB, Deschamps F, and Papadopoulos V (2015) Cyclohexane-1,2-dicarboxylic acid diisononyl ester and metabolite effects on rat epididymal stromal vascular fraction differentiation of adipose tissue, Environmental Research 140:145-156 received national and international media attention and Dr. Papadopoulos was interviewed by local and international media and magazines, including CTV International, Qmed news, Medical Product and Manufacturing News, Chemical Watch, etc.
The paper by Lee S, Martinez–Arguelles DB, Campioli E, Papadopoulos V (2017) entitled fetal exposure to low levels of the plasticizer DEHP predisposes the adult male adrenal gland to endocrine disruption, Endocrinology, 155:1667-1678, was highlighted in the April 2017 issue of the French Endocrine Society Newsletter.
PROFESSIONAL SOCIETIES:
Academy of Managed Care Pharmacy
American Association for the Advancement of Science
American Association of Pharmaceutical Scientists
American Chemical Society
American Pharmacists Association
American Society of Andrology
American Society of Biochemistry and Molecular Biology
American Society of Gene and Cell Therapy
American Society of Microbiology (past)
Canadian Society of Endocrinology & Metabolism (past)
Endocrine Society, USA
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International College of Neuropsychopharmacology
International Pharmaceutical Federation
Society for the Study of Reproduction
Society of Toxicology
The New York Academy of Science
PUBLIC SERVICE:
Ad hoc committee member of NICHD Program Projects Study Section, NIH, USA (1991)
Ad hoc committee member of NIEHS Program Projects Study Section, NIH, USA (1995)
Ad hoc committee member of Reproductive Biology Study Section, NIH, USA (1996, 1998, 2002)
Ad hoc reviewer for National Science Foundation, USA (1991-1998)
Ad hoc reviewer for the National Research Foundation of Switzerland (1992, 1998)
Ad hoc reviewer on the "Abstract Review Committee" for the Annual Meeting of the American Society of Andrology, USA (1992)
Ad hoc reviewer for the Israel Science Foundation, Israel (1993, 1994, 1998, 2000, 2003, 2008-2013)
Organizer of the VIIth Mid-Atlantic Reproductive Biology Meeting, Georgetown University Medical Center, June 3, Washington, DC, USA (1994)
Chair of the session "Acute regulation of steroidogenesis" at the International Congress of Steroid Hormones, Dallas, TX, USA (1994)
Ad hoc reviewer for the Department of Veterans Affairs, USA (1996)
Ad hoc reviewer for the United States-Israel Binational Science Foundation, USA (1997, 2002,2003)
Ad hoc reviewer for the Australian Research Council, Australia (1997, 1998)
Ad hoc committee member of Alcohol and Toxicology Study Section, NIH, USA (1998)
Ad hoc reviewer for the National Health and Medical Research Council of Australia, Australia (1999, 2000)
Ad hoc reviewer for the Alzheimer’s Association Chicago, IL, USA (1999, 2000)
Member, Environmental Health Sciences Review Committee, NIEHS, NIH, USA (1999-2003)
Ad hoc reviewer for the Environmental Health Sciences Review Committee, NIEHS, NIH, USA (2004, 2005)
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Ad hoc reviewer for Scientific Review Committee, NIDDK, NIH, USA (2000)
Member of the Complementary and Alternative Medicine Advisory Committee of the National Brain Tumor Foundation, USA (2000-2004)
Ad hoc reviewer for the Natural Sciences and Engineering Research Council of Canada (NSERC), Canada (2001, 2009-2016)
Member of the Public Affairs Committee of the Society for the Study of Reproduction, USA (2002-2004)
Member (Associate) of the Board of Directors of the Federation of the Association of the Societies for Experimental Biology (FASEB), USA (2003-2005)
Representative for the Society for the Study of Reproduction at the FASEB Public Affairs Executive Committee (PAEC) , USA (2003-2004)
External advisor of the Neuroimmunomodulation Research Group (Director: Dr. J. Palermo-Neto) at the University of Sao Paulo, Brazil (2004-2012)
Ad hoc reviewer for the Environmental Health Sciences Review Committee, NIEHS, NIH, USA (2004)
Reviewer for the International Science Foundation, Stockholm, Sweden (2004)
Member of Organizing Committee of the XVIII Testis Workshop, Seattle, Washington, USA (2005)
Chair of the session "Steroidogenesis" at the XVIII Testis Workshop, Seattle, Washington, USA (2005)
Chair and organizer, international consortium for reassigning a name to the peripheral-type benzodiazepine receptor protein, Washington, DC, USA (2004-2005)
Ad hoc reviewer for the Environmental Health Sciences Review Committee, NIEHS, NIH, USA (2005)
Ad hoc reviewer for the Ministry of Technology of Greece, Greece (2005)
Reviewer of the School of Biomedical Sciences, The Ohio State University College of Medicine and Public Health, USA (2005)
Member of Organizing Committee of the XIX Testis Workshop, USA (2007)
Member of Pediatrics Board in Washington DC, USA (2005-2008)
Ad hoc committee member of Integrated Clinical Endocrinology and Reproduction Study Section, NIH, USA (2005)
Ad hoc committee member of Neurotoxicity and Alcohol Study Section, NIH, USA (2006)
Ad hoc reviewer for the Canadian Institutes of Health Research, Ottawa, Canada (2006)
Member of Cellular, Molecular and Integrative Reproduction Study Section, NIH, USA (2006-2010)
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Member, Executive Leadership Group of Vice-Presidents for Research, Association of Academic Health Centers, Washington, DC, USA (2006-2009)
Member, Quebec delegation for scientific and commercial cooperation to Lyon, France (2006)
Ad hoc reviewer for the Germany-Israel Foundation for Scientific Research and Development, Germany (2006-2007, 2011)
Chair, Symposium on Neurosteroid Biosynthesis & Actions in the Brain, Endocrine Society, Annual meeting, June 2-5, Toronto, Canada (2007)
Member, Board of Directors and Member, Executive Committee, Montreal In Vivo, Canada (2007-present)
President and Member, Board of Directors, Montreal-Excellerator, a McGill University and McGill University Health Center company. Canada (2007-2014).
Member, US Army Medical Research and Materiel Command Breast Cancer Research Program Review Committee, August 12-14, Alexandria, Virginia, USA (2007)
Ad hoc committee member of Pharmaceutical Sciences peer review committee, Canadian Institutes of Health Research (CIHR), Ottawa, Canada (2007)
Ad hoc reviewer for the Wellcome Trust, UK (2007-2010)
Member, Local Organizing Committee, 13th International Congress on Hormonal Steroids and Hormones & Cancer. September 27-30, Quebec City, Canada (2008)
Member, Suzan G. Komen Foundation Systemic Therapy Program Review Committee, January 8-9, Alexandria, Virginia, USA (2008)
Member and speaker, Forum on the Big Projects of the Greater Montreal Metropolitan area, Board of Trade of Metropolitan Montreal, Canada (2008, 2010)
Member of the American Society of Andrology Council, USA (2008-2011)
Member Scientific Committee of International Congress of Pathophysiology, ISP2010, June 27-30, Montreal, Canada (2008-2010)
Ad hoc reviewer for the Canada Research Chairs program, Canada (2008)
Member, Quebec delegation for scientific and commercial cooperation to Shanghai, China (2008)
Member Environmental Health Sciences Review Committee for Superfund applications, NIEHS, NIH, USA (2008, 2009)
Member, Evaluation Committee of Dr. Olivier Lesouhaitier’s ability to direct research at the University of Rouen, Rouen, France (2008)
Member, Board of Directors, Centre Québécois sur la Découverte du Médicament, Canada (2008-present)
Member, Board of Directors, Centre Québécois de Valorisation des Biotechnologies (CQVB), Canada (2009-2015)
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Member, Executive Committee of the Organization of Testis Workshops, USA (2009-2011)
Member, Advisory Committee School of Biomedical Sciences and Faculty of Medicine, Chinese University of Hong Kong, Hong Kong (2009-2014)
Member, Advisor Committee to the Quebec Government to define Quebec’s Strategy for Research and Innovation, Ministère du Développement Économique, de l'Innovation et de l'Exportation, Canada (2009)
Member, Advisor Committee to the President of the Fonds de la recherché en santé de Quebec, Canada (2009-1011)
Leader, California-Canada Initiative on Personalized Health Management, US-Canada (2009-2010)
Member, Review Committee for King Faisal Hospital & Research Centre, Riyadh, Saudi Arabia (2009)
Member, FRSQ and Montreal In Vivo group for the development of Personalized Medicine, Canada (2010-present)
Member and speaker, Forum on the Grand Development Projects, Board of Trade of Metropolitan Montreal, Canada (2010)
Member and speaker, Forum on Creative Partnerships in Biopharmaceutical Research, Montreal, Canada (2010)
Member, Program Organizing Committee, 14th International Congress on Hormonal Steroids and Hormones & Cancer. September 21-24, Edinburgh, Scotland, UK (2010)
Chair and organizer, Symposium on Environmental exposures on male reproduction. International Congress of Pathophysiology, ISP2010, June 27-30, Montreal, Canada (2010)
Co-Chair, Local Arrangements Committee, American Society of Andrology 2011 annual meeting at Montreal, Canada (2010-2011)
Ad hoc reviewer for the National Fellowships Committee for Sigma Delta Epsilon, Graduate Women in Science, USA (2010)
Chair, Roundtable on Medicine 2020. Institute for Strategic Analysis and Innovation, Montreal, Canada (2010)
Member, Quebec delegation for scientific and commercial cooperation to Bavaria, Germany (2010)
Member, Assessment panel in Biological and Medical Sciences for the Ministry of Education Life Long Learning and Religion Affairs- responsible for Higher Education, Research and Technology, Athens, Greece (2010-2011)
Ad hoc committee member of NIEHS R13 Special Study Section, NIH, USA (2011)
Chair, Scientific Program Committee, American Society of Andrology 2013 annual meeting at San Antonio, Texas, USA (2011-2013)
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Member, Society for the Study of Reproduction (SSR) Development Committee, USA (2011-2017)
Member, Society for the Study of Reproduction (SSR) Annual Meeting/Industrial Relations Subcommittee (AMIR), USA (2011-2017)
Evaluator for the South Africa's National Research Foundation, South Africa (2011-2016)
Member, Board of Directors, Fonds de la Recherche du Québec - Santé (FRQS), Canada (2011-present)
Member, Board of Directors, The Board of Trade of Metropolitan Montreal. The Board of Trade represents the business community of the Greater Montreal and is involved in economic development of the city and all aspects of the economic growth and prosperity of the people of Montreal. Canada (2011-2012)
Member, Executive Committee, Board of Directors, Fonds de la Recherche Québec - Santé du Québec (FRQS), Canada (2011-present)
Co-organizer, Symposium on Alzheimer’s disease, recent progress and perspectives. National Academy of Medicine, October 24, Paris, France (2011)
Member, Scientific Advisory Board for the FRSQ Groupe de recherche axé sur la structure des protéines (GRASP), Quebec, Canada (2011-2014)
Member, Organizing Committee, Réseau Québécois en Reproduction Workshop on Knowledge Translation, Montreal, Quebec, Canada (2011)
Ad hoc reviewer for the Foundation for Polish Science Executive Board, Poland (2011)
Ad hoc committee member of Endocrinology peer review committee, Canadian Institutes of Health Research (CIHR), Ottawa, Canada (2011-12)
Member, Knowledge transfer committee, Réseau Québécois en Reproduction, Quebec, Canada (2012-present)
Co-organizer of the “Mass spectrometry-based tissue imaging: improving diagnostics and healthcare” symposium, Toronto, Canada (2012)
Co-Chair, Symposium on “Molecular Neurobiology/pharmacology: The translocator protein (18-kDa) as a novel target in neurology and psychiatry“; International College of Neuropsychopharmacology (CINP), June 5, Stockholm, Sweden (2012)
Member, Comité stratégique en science et innovation, Quebec’s National Strategy for Research and Innovation, Ministère du Développement Économique, de l'Innovation et de l'Exportation and now Ministry of Higher Education, Research, Science and Technology, Quebec Government, Canada (2012)
Ad hoc reviewer for the Biotechnology and Biological Sciences Research Council, Research Councils UK, UK (2012-2015)
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Member, Therapeutic Discovery Review Team, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, USA (2012-2013)
Member, Health Sector Committee, Palais de Congress de Montreal, Montreal, Canada (2012-2014)
Co-Chair, Committee of Vice-Presidents of Health Research and ex officio Member of the Board, Association of Canadian Academic Healthcare Organizations, Ottawa. Canada (2012-2014)
Ad hoc reviewer for the Netherlands Organisation for Scientific Research (NWO), Den Haag, Netherlands (2012)
Member, National Scientific Advisory Council, American Federation for Aging Research, USA (2012-present)
Member, Advisory Committee, Regroupement en soins de santé personnalisés du Québec, Montréal, Canada (2012-present)
Ad hoc reviewer for the Canadian Foundation of Innovation, Leaders Opportunity Fund, Canada (2013)
Ad hoc reviewer for the Research Council of the Académie universitaire 'Louvain', Belgium (2013)
Ad hoc reviewer for the National Council for Science and Technology of Greece, Greece (2013)
Member, Institute Advisory Board, CIHR Institute of Human Development, Child and Youth Health, Canada (2013-2016)
Ad hoc reviewer for the California Department of Public Health (CDPH) Alzheimer's Disease Program, CA, USA (2013)
Co-organizer, Symposium on “Vieillissement et démences, un triple défi médical, social et économique”. National Academy of Medicine, October 24, Paris, France (2013)
Member, MITACS College of Reviewers (COR), Canada (2013-present)
Member, Endocrinology peer review grant committee, Canadian Institutes of Health Research (CIHR), Ottawa, Canada (2013-14)
Co-Chair, Session I on Molecular Medicine, 16th International Symposium on Molecular Medicine, Creta Maris Resort, Greece (2013)
Member, Montreal -in-Vivo & Life Sciences Ontario Panel on Intellectual Property, November 5, Rideau Club, Ottawa, Canada (2013)
Member, Scientific Program Committee, North American 2015 Testis Workshop, April 15-18, Salt Lake City, Utah USA (2013-2015)
Member, Scientific committee, INMiND Consortium, Symposium on TSPO, April 24-25, Manchester, UK (2014)
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Vice-President and President-elect, American Society of Andrology, Chicago, IL, USA (2014-2015)
Member, American Society of Andrology Council, USA (2014-2017)
Ad hoc reviewer for Heart Research, UK (2014)
Chair, Session on Do steroids get better with age? International Congress of Endocrinology, Endocrine Society, June 220-25, Chicago, USA (2014)
Chair, Scientific Advisory Committee, School of Biomedical Sciences and Faculty of Medicine, Chinese University of Hong Kong, Hong Kong (2015-2018)
Member, Transitional Board of Directors, and Co-Chair, Committee of Vice-Presidents of Health Research, Ottawa. HealthCareCAN, Ontario, Canada (2014-2015)
Member, Founding Board of Directors, and Co-Chair, Committee of Vice-Presidents of Health Research, HealthCareCAN, Ottawa, Ontario, Canada (2015-2016)
Chair, Session on Critical Initiatives in Academia and Philanthropy, Biotechnologia, Fondation santé, June 25-28, Daios Cove, Crete, Greece (2014)
Reviewer, Abstracts and Communications, Endocrine Society Annual Meetings, Baltimore, MD, USA (2014-2017)
Member, Program Committee Innovating Children’s and Families’ Health, CIHR, November 17-18, Ottawa, Canada (2014)
President, American Society of Andrology, Chicago, IL, USA (2015-2016)
Moderator, Federal Heath and Life Sciences Programs session; Academic Health Sciences Network Symposium, March 31-April 1st, Delta Hotel, Ottawa, Canada (2015)
Chair of Human Fertility, Infertility and the Next Generation Session, 2015 North American Testis Workshop, April 15-18, Salt Lake City, Utah USA (2015)
Co-Chair, Scientific Program Committee, North American 2017 Testis Workshop, USA (2015-17)
Chair, Environmental Health Sciences evaluation committee, Yale School of Public Health, August 23-25, New Haven, Connecticut, USA (2015)
Reviewer, Cancer Association of South Africa, Mowbray, South Africa (2015)
Co-organizer, Symposium on “Mobilité et Vieillissement”. National Academy of Medicine and Réseau Québécois de Recherche sur le Vielissement”, September 30, Montreal, Canada (2015)
Panelist, Rx&D Conference “Making Canada Better”; Panel on Clinical Research, November 17, Montreal, QC, Canada (2015).
Member, Selection Committee for the 2016 Prix Wilder Peinfield, Governemnt of Quebec. The Prix Wilder-Penfield is an award by the Government of Quebec that is part of the Prix du Québec, which "goes to scientists whose research aims fall within the field of
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biomedicine. These fields include the medical sciences, the natural sciences, and engineering".QC, Canada (2016)
Organizer, Symposium on patient engagement in clinical research, Ninth annual symposium of the McGill University Health Centre's Institute for Strategic Analysis and Innovation (MUHC-ISAI), June 30, Montreal, QC, Canada (2016)
Evaluator for promotion and tenure of Faculty members of the School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong (2016)
Chair, Nominating Committee, American Society of Andrology, USA (2016-17)
Evaluator for promotion of Faculty members of the Schools of Health Sciences and Medicine at the National and Kapodistrian University of Athens, Greece (2016-17)
Member, CIHR Project Grant Competition Review Committee, Canada (2017)
Member of the Vascular and Hematology Special Emphasis Panel, NIH, USA (2017)
Ad hoc member of the National Advisory Child Health and Human Development Council (NACHHD) at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), USA (2017)
JOURNAL EDITORIAL BOARDS
Member, Editorial Board of the journal Steroids (2001-present)
Member, Editorial Board of the journal Neurobiology of Lipids (2003-present)
Member, Editorial Board of the journal Biology of Reproduction (2004-2012)
Member, Editorial Board of the Hoya Technical & Research Bulletin (2004-2010)
Member, Editorial Board of the Journal of Andrology (2005-2012)
Member, Editorial Board of the journal Recent Patents on Endocrine & Metabolism Drug Discovery (2006-present)
Member, Editorial Board of the journal Open Access Bioinformatics (2009-present)
Member, Editorial Board of the journal Pathology and Laboratory Medicine International (2009-present)
Member, Editorial Board of the journal Cholesterol (2009-present)
Member, Editorial Board, Journal of Alzheimer’s Disease (2011-2012)
Member, Editorial Academy (Board), International Journal of Molecular Medicine (2013-present)
JOURNAL REVIEWS
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Ad hoc reviewer for the following journals:
ACS Chemical Biology
ACS Chemical Neuroscience
American Journal of Physiology
American Journal of Obstetrics & Gynecology
Atherosclerosis
Basic and Clinical Andrology
Behavioral Brain Research
Biochimie
Biochemistry
Biochemistry & Cell Biology
Biochimica & Biophysica Acta – Bioenergetics
Biochimica & Biophysica Acta – Biomembranes
Biochimica & Biophysica Acta – General Subjects
Biochimica & Biophysica Acta – Molecular and Cell Biology of Lipids
Biochimica & Biophysica Acta – Molecular Cell Research
Biochemistry & Biophysics Reports
Biochemical Pharmacology
Biology of Reproduction
Biomarkers in Medicine
Bioorganic & Medicinal Chemistry Letters
BMC Clinical Epigenetics
BMC Plant Biology
Breast
Canadian Journal of Physiology and Pharmacology
Cancer Biomarkers
Cancer Letters
Cancer Research
Cancer Therapy
Carcinogenesis
Cell Biology & Toxicology
Cell & Molecular Life Sciences
Cell Reports
Cell Tissue Research
Chemosphere
Cholesterol
Circulation
Clinical Cancer Research
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Comparative Biochemistry & Physiology
Computational Biology and Chemistry
Computational and Structural Biotechnology Journal
Current Molecular Medicine
Current Topics in Medicinal Chemistry
Developmental Biology
DNA and Cell Biology
Drug Metabolism & Disposition
Endocrine
Endocrinology
Environmental Health Perspectives
Environmental Research
EMBO Journal
European Journal of Biochemistry
European Journal of Pharmacology
European Surgical Research
Experimental Brain Research
Experimental Gerontology
Expert Opinion on Therapeutic Patents
Expert Opinion in Drug Discovery
Expert Review of Clinical Immunology
FASEB Journal
FEBS Letters
Free Radical Biology & Medicine
Frontiers in Cellular Neurosciences
Frontiers in Endocrinology
Frontiers in Neuroendocrinology
Future Neurology
Gene
Glia
Hormone Metabolic Research
Human Molecular Genetics
International Journal of Andrology
International Journal of Environmental Research and Public Health
International Journal of Molecular Sciences
International Union Biochemistry & Molecular Biology Life
Journal of Andrology
Journal of Biological Chemistry
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Journal of Biomedical Materials Research: Part B - Applied Biomaterials
Journal of Endocrinology
Journal of Hepatology
Journal of Leukocyte Biology
Journal of Lipid Research
Journal of Medicinal Chemistry
Journal of Neurochemistry
Journal of Neuroscience
Journal of Neuroscience Research
Journal of Pharmacology & Experimental Therapeutics
Journal of Pharmacy & Pharmacology
Journal of Receptor Research
Journal of Steroid Biochemistry & Molecular Biology
Life Sciences
Longevity and Healthspan
Medicinal Chemistry Letters
Membranes
Molecular Cancer Therapeutics
Molecular Carcinogenesis
Molecular Cellular Endocrinology
Molecular Imaging & Biology
Molecular Pharmacology
Molecular Pharmaceutics
Molecular Psychiatry
Molecular Reproduction and Development
Molecular Therapy (Nature)
Molecular Therapy – Methods & Clinical Development
Molecules
Nature Comminications
Nature Medicine
Nature Chemical Biology
Neurochemical Research
Neurochemistry International
Neuroscience
Neuropharmacology
Neuropsychopharmacology
Nutrition & Diabetes
Obesity
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Open Biology
Pathology and Laboratory Medicine International
Pharmaceutical Research
Pharmacology and Toxicology
Pharmacological Reviews
PLOS One
Proceedings of the National Academy of Sciences, USA
Progress in Neurobiology
Proteomics
Psychoneuroendocrinology
Psychopharmacology
Recent Patents on Endocrine, Metabolic and Immune Drug Discovery
Redox Reports
Regulatory Peptides
Regulatory Toxicology and Pharmacology
Reproduction, Nutrition, Development
Reproductive Biology and Endocrinology
Reproductive Toxicology
Science of the Total Environment
Science Translational Medicine
Scientific Reports (Nature)
Steroids
Structure
The Plant Journal
Toxicology Letters
Toxicological Sciences
Trends in Biochemical Sciences
UNIVERSITY SERVICE:
Member of the Departmental Executive Faculty Committee (1990-1992; 1997-1999)
Interviewer of Medical student applicants (1990-2002)
Interviewer of Graduate student applicants (1991-2007)
Group discussion leader for Departmental Faculty Retreat (1991)
Member of the Departmental Faculty Search Committee (1992, 1995, 1999, 2000)
Departmental liaison for the Radiation Safety Office (1993-1994)
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Member of the Georgetown University Radiation Safety Committee (1993-1998)
Member of the Departmental Space Committee (1994-1997)
Coordinator of the Neuroscience Program Seminars (1994-95)
Member of the Internal Scientific Advisory Board for the Georgetown Institute for Cognitive and Computational Sciences (1995-1996)
Interviewer of Graduate Student Applicants for the Neuroscience Program (1995-2003)
Member of the Departmental Finances Committee (1996-2000)
Member of the Georgetown University Medical Center Research Committee (1996-2000; 2002-2004)
Member of the Georgetown University Medical Center Committee on Faculty (1996-present)
Interviewer of M.D./Ph.D. students (1997-1998)
Member of the Neuroscience Curriculum Committee (1997-1998)
Member of the Georgetown University Transgenic Facility Oversight Committee (1997-2000)
Member of the American Cancer Society Institutional Research Grant Review Committee (1998-2003)
Member of the Georgetown University Medical Center Space Committee (1998-1999)
Member of the Executive Advisory Council to the Office of the Executive Vice–President and the Chief Executive Officer of the Georgetown University Medical Center (1998-2000)
Member of the Academic Planning Committee (Research Subcommittee) Georgetown University (1999-2000)
Member of the Georgetown University Committee on Patents, Licensing, Copyrights, and Technology Transfer (1999-2003)
Preclinical course reviewer for Georgetown University School of Medicine (2000)
Chair, Committee on General Facilities, Georgetown University School of Medicine (2000-2002)
Member of the Lombardi Cancer Center Animal Research Advisory Committee (2000-2002)
Member of the Neuroscience Graduate Student Advisory Committee (2001-2003)
Committee on Complementary Alternative Medicine and Integrative Medicine Curriculum (2001-2005)
Member of the Georgetown University Faculty Senate Committee on Academic Freedom and Responsibility (2002-2004)
Member of the Transgenic Task Force, Lombardi Cancer Center (2002-2007)
Judge for the Lombardi Cancer Center Research Days presentations (2003)
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Member, Georgetown University Medical Center Executive Committee (2003-2007)
Chair, Committee on Graduate Education Resources (2003)
Member, Medicinal Chemistry Task Force, Lombardi Cancer Center (2003-2004)
Member, Georgetown University Medical Center Committee on Research and Education Space (2003-2005)
Member, Faculty Task Force (2003-2005)
Chair, Drug Development Initiative Georgetown University - Virginia Technological University (2004-2005)
Member, Georgetown University Medical Center Restructuring Advisory Committee (2004)
Member, Internal Advisory Committee, Georgetown Alzheimer’s Disease Research Center (2004-present)
Co-Chair, Georgetown University Research re-organization initiative (08/04–06/05)
Member, Scientific Advisory Committee, AP4 Center (2005-2006)
Member, Georgetown University Executive Committee (2005-2007)
Member, Oversight Scientific Advisory Board, Protein Information Resource, UniProt Program (2005-2007)
Member, Executive Committee, Drug Development Center, Georgetown University-Virginia Technological University (2005–2007)
Member, Director’s General Leadership Council, McGill University Health Centre (2007-2012)
Member, McGill University Faculty of Medicine Leadership Council (2007-2016)
Member, McGill University Health Centre Strategic Research Planning Committee (2007-2011)
Member, Research Policy Council, McGill University (2007-2012)
Member, Search Committee for Director of Genome Quebec McGill Innovation Center (2008-2010)
Member, Search Committee for Chair of Psychiatry, McGill University (2008)
Member, McGill University Health Centre Redevelopment Planning Committee (2008-2015)
Member, McGill University Innovation Committee (2009-2010)
18. Mr. Jen-Kai Chen (2008, Neurological Sciences, McGill University)
19. Ms. Cassandra Cartagena (2008, Interdisciplinary Program in Neurosciences, Georgetown University)
20. Ms. Annelise Chapalain (2008, University of Rouen, France)
21 Mr. Jacob Hascalovici (2013, Technion University-McGill University)
22 Ms. Margaret Redpath (2015, Pathology, McGill University)
23 Mr. Sanne Janszen (2015, Pathology, McGill University)
Member of the Qualifying/Comprehensive Examination Committees of the following students:
1. Ms. Hala Azzam, Department of Cell Biology, Georgetown University
2. Mr. Steven Seslar, Department of Cell Biology, Georgetown University
3. Ms. Isabelle Lacaci, Department of Cell Biology, Georgetown University
4. Mr. Radhakrishnan, Department of Cell Biology, Georgetown University
5. Mr. Robert Delsite, Department of Cell Biology, Georgetown University
6. Mr. Robert Fryer, Department of Cell Biology, Georgetown University
7. Mr. Prasit Pavasant, Department of Cell Biology, Georgetown University
8. Ms. Beth Pflug, Department of Cell Biology, Georgetown University
9. Mr. Keith Orford, Department of Cell Biology, Georgetown University
10. Mr. Jehng-Kang Wang, Department of Cell Biology, Georgetown University
11. Ms. Xanthia Samaropoulos, Department of Pharmacology, Georgetown University
12. Mr. Ahmad Daher, Department of Biochem & Mol Biology, Georgetown University
13. Ms. Valerie Trabosh, Department of Biochem & Mol Biology, Georgetown University
TEACHING ACTIVITIES:
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Lecturer in Reproductive Biology course, University of Caen (1984-1986)
Lecturer in Signal Transduction course, University of Caen (1984-1986)
Lecturer in Molecular Cellular Physiology course, Georgetown University (1989)
Lecturer in Molecular Cell Biology course, Georgetown University (1989-1996)
Lecturer in Human Reproduction course, Georgetown University (1989-1996)
Lecturer in Neurosciences Survey course, Georgetown University (1990-1991)
Laboratory Instructor in Gross Anatomy course, Georgetown University (1990-2002)
Course director of Reading Tutorial course, Georgetown University (1990-1993)
Faculty advisor for Graduate Student Seminar series, Georgetown University (1990-1993)
Lecturer in Techniques in Cell Biology course, Georgetown University (1991-1994, 2000-2003)
Course Director and Lecturer for the Molecular and Cellular Endocrinology course, Georgetown University (1993-2000)
Facilitator: Problem Based Learning; completion of training and participation as a facilitator in the teaching of Anatomical Sciences to medical students, Georgetown University (1993-1995)
Lecturer in Gross Anatomy course, Georgetown University (1994-2002)
Lecturer in Neuropharmacology course, Georgetown University (1996-2007)
Co-coordinator of Current Topics in Cancer Research course, Georgetown University (1997-2000)
Course co-Director and Lecturer for the Alternative Medicine series of the Georgetown University Mini-Medical School (1999-2002)
Lecturer in the series on Holistic Medicine Survey, Georgetown University (2000)
Lecturer in Medical Endocrinology course, Georgetown University (2004, 2005)
Lecturer in Metabolism course, Georgetown University (2004)
Lecturer in Fundamentals of Biochemistry and Molecular Biology course, Georgetown University (2004-2007)
Lecturer in Neurosciences Survey course, Georgetown University (2004-2007)
Lecturer in Biochemical and Cellular Sciences course, Georgetown University (2005-2007)
Lecturer in Advanced Endocrinology course (EXMD 502), McGill University (2007-present)
Lecturer in Clinician Investigator Program, McGill University (2009-present)
Lecturer in Mini Pharma Series, McGill University (2010)
Supervisor in Biotechnology Research Project (BTEC623), McGill University (2009-2012)
Supervisor in Pharmacology Research Project (PHAR599), McGill University (2011-2014)
Supervisor in Undergraduate Research Project (BIOC396), McGill University (2011-2012)
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Lecturer in Topics in Pharmacology (The other side of drugs; PHAR707; CRN15441), McGill University (2012)
Supervisor in Undergraduate Research Project (BIOC491), McGill University (2013)
Lecturer in Clinical Pharmacology & Toxicology Program, McGill University (2013)
Lecturer in Introduction to Pharmacology (PHAR200), McGill University (2015)
Lecturer in MD/PhD Program, McGill University (2016)
Lectured in Endocrine Therapeutics (PHRD 603), University of Southern California (2017)
Graduate & Undergraduate Students:
1. Co-Advisor for Ms. Cynthia M. Davis, Cell Biology Graduate Program, Georgetown University (Ph.D., 1990)
2. Advisor for Ms. Rachel C. Brown, Interdisciplinary Program in Neuroscience, Georgetown University (Ph.D., 2000)
3. Advisor for Mr. Matthew J. Hardwick, Cell Biology Graduate Program, Georgetown University (Ph.D., 2000)
4. Advisor for Mr. Keith Barlow, Cell Biology Graduate Program, Georgetown University (Ph.D., 2005)
5. Advisor for Mr. Christoforos Giatzakis, Cell Biology Graduate Program, Georgetown University (Ph.D., 2005)
6. Advisor for Ms. Malena Rone, Biochemistry & Molecular Biology Graduate Program, Georgetown University (Ph.D., 2010)
7. Advisor for Ms. Amani Batarseh, Biochemistry & Molecular Biology Graduate Program, Georgetown University (Ph.D., 2010)
Medical students who had research training/rotation in Dr. Papadopoulos' laboratory:
1. Mr. Farhat Nowzari (1990, M’93)
2. Ms. Paulina Silver (2000, M’03)
3. Mr. Derek Shia (2000, M’03)
4. Mr. Andrew Tassler (2001, M’04)
5. Mr. Christopher Wall (2002, M’06)
Postdoctoral/Research Fellows/Research Associates and Visiting Scientists/Scholars:
1. Dr. Meng-Chun Jia (WHO Fellow, 1989-1990)
2. Dr. Shane A. Brown (Visiting Scientist on Sabbatical, UNSW, Australia, 1990)
3. Dr. Jean-Luc Gaillard (NATO Fellow, 1991)
4. Dr. Martine Garnier (Research Fellow, 1991-1994)
5. Dr. Noureddine Boujrad (Research Fellow, 1992-1996; Res. Assistant Professor, 1997-1998)
6. Dr. Ghenima Dirami (Research Fellow, 1992-1993)
7. Dr. Alexander Borisov Dimchev (Research Fellow, 1992-1993)
8. Dr. Choong-Hee Lee (Kyung-Hee Univ. Fellow, 1993-1994)
9. Dr. Stephen O. Ogwuegbu (Rockefeller Fellow, 1993-1995)
10. Dr. Hakima Amri (Research Fellow, 1994-1997; Research Associate, 1997-1999; Res. Assistant Professor, 1999-2002)
11. Dr. Caterina Cascio (Research Fellow, 1995-1998)
12. Dr. Hua Li (Research Fellow, 1995-1998; Research Associate, 1998-2001)
13. Dr. Veronique Taupin (Visiting Scientist, Synthelabo Recherche, France, 1996)
14. Dr. Maria Kotoula (Visiting Scientist on Sabbatical, Univ. of Thessaloniki, Greece, 1996 & 1998)
15. Dr. Zhixing Yao (Research Fellow, 1996-2007)
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16. Dr. Djamil Frettick (Research Fellow, 1997-1998)
17. Dr. Eleni Dicou (Visiting Scientist on Sabbatical, INSERM, France, 1997)
18. Dr. Jane Dees (Research Associate, 1998-2001)
19. Dr. Maria Gazouli (Research Fellow, 1998-1999)
20. Dr. Babette Degenhardt (Visiting Scientist, University of Halle, Germany, 1999-2000)
21. Dr. Ying Liu (Research Fellow, 1999-2005)
22. Dr. Zeqiu Han (Research Fellow, 2000-2005)
23. Mr. Raphael Thuillier (Visiting Scientist, University of Rouen, France, 2000)
24. Dr. Peter Shalamanov (Research Fellow, 2000-2001)
25. Dr. Ewald Pretner (Research Fellow, 2000-2002)
26. Mr. Gregor Wendler (Visiting Scientist, University of Halle, Germany, 2001-2002)
27. Mr. Franc Delavoie (Visiting Scientist, University of Paris VI, France, 2001-2003)
28. Dr. Thierry Hauet (Research Fellow, 2001-2002)
29. Dr. Jun Liu (Research Fellow, 2001-2005; Instructor, 2006-2007)
30. Dr. Wenping Li (Research Fellow, 2001-2005; Res. Associate, 2006-2008)
31. Dr. Laurent Lecanu (Research Fellow, 2001-2003; Res. Assistant Professor, 2004-2007)
32. Dr. Chengming Zheng (Research Fellow, 2001-2002)
33. Dr. Jing Xu (Research Fellow, 2001-2003; Res. Assistant Professor, 2004-2006)
34. Dr. Dimitrios Kletsas (Fogarty Fellow, Visiting Scientist, National Center of Research Demokritos, Athens, Greece, 2002)
35. Dr. Saer Diallo (Research Fellow, 2002-2003)
36. Dr. Laurent Tillement (Research Fellow, 2003-2005)
37. Dr. Kerstin Maaser (Visiting Scientist, Charite School of Medicine, University of Berlin, Germany, 2004)
38. Dr. Andreas P. Sutter (Visiting Scientist, Charite School of Medicine, University of Berlin, Germany, 2004)
39. Dr. Nagaraju Akula (Research Fellow, 2005-2007; Visiting Scientist, 2009-today)
40. Dr. Tatiana Ruskha (Merck Fellow, Krasnoyarsk State Medical Academy, Russia, 2005)
41. Dr. Sonia Chalbot (Research Fellow, 2005-2007)
42. Dr. Paula Maloberti (Bunge & Borg Fellow, University of Buenos Aires School of Medicine, Argentina, 2005)
43. Dr. Patrizia Pfliss (Visiting Scientist, Charite School of Medicine, University of Berlin, Germany, 2005)
44. Ms. Fernanda Castillo (Bunge & Borg Fellow, University of Buenos Aires School of Medicine, Argentina, 2006)
45. Ms. Monica Sakai (CAPES foundation, University of Sao Paolo, Brazil, 2007-2008 & 2010-2015)
46. Dr. Jinjiang Fan (Research Associate, 2007-present)
47. Dr. George Rammouz (Research Fellow, 2007-2011)
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48. Dr. Ivona Dinca (Research Fellow, 2007-2009)
49. Dr. Huijie Wang (Research Associate, 2008-2009)
50. Dr. Andrew Mitzak (Research Fellow, 2008-2013; Research Associate, 2014-2016)
51. Dr. Theodore Guichard (Visiting Fellow, School of Pharmacy, Lyon University, France, 2009)
52. Dr. Enrico Campioli (Visiting Fellow, University of Modena, 2009-2010 & Research Fellow 2011-present)
53. Dr. Marie-Charlotte Lienhart (Visiting Fellow, School of Pharmacy, Lyon University, France, 2010)
54. Dr. Malena Rone (Research Fellow, 2010-2014)
55. Dr. Amani Batarseh (Research Fellow, 2010-2011)
56. Dr. Daniel Benja Martinez Arguelles (Research Fellow, 2011-2014; Research Associate, 2014-present)
57. Dr. Pauline Guerci (Visiting Fellow, School of Pharmacy, Lyon University, France, 2011)
58. Dr. Leeyah Issop (Research Fellow, 2011-2015)
59. Dr. Stephane Bassi (Visiting Fellow, School of Pharmacy, Lyon University, France, 2012)
60. Dr. Laure Chevassus-Rosset (Visiting Fellow, School of Pharmacy, Lyon University, France, 2012)
61. Mr. Edward Daly (Research Associate, 2012-2017)
62. Dr. Aline Harlay (Visiting Fellow, School of Pharmacy, Lyon University, France, 2013)
63. Dr. Nouel de Kerangue (Visiting Fellow, School of Pharmacy, Lyon University, France, 2014)
64. Dr. Cheimia Chebbi (Visiting Fellow, School of Pharmacy, Lyon University, France, 2014)
65. Dr. Linhuo Jiang (Visiting Professor, School of Biotechnology, Jiangnan University, Cina, 2015-2016)
67. Dr. Lu Li (Research Fellow, 2017-present)
Student and Fellow Awards:
1994 Dr. Martine Garnier, postdoctoral fellow in Dr. Papadopoulos’ lab, won the Interdepartmental Research Fellow Award for the paper entitled: "The polypeptide diazepam binding inhibitor and a higher affinity peripheral-type benzodiazepine receptor sustain constitutive steroidogenesis in the R2C Leydig tumor cell line".
1996 Dr. Hakima Amri, postdoctoral fellow, was a finalist (2nd) for the Interdepartmental Research Fellow Award for the paper entitled “Mechanisms underlying stress control: role of the Ginkgo biloba extract EGb 761 and the peripheral-type benzodiazepine receptor”.
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2000 Dr. Maria Gazouli, postdoctoral fellow, won the Outstanding Research Award from the Hellenic Medical Society for her work on the characterization of the mechanism of action of peroxisome proliferators on gene expression, presented at the Annual Meeting of the Hellenic Medical Society on May 2000.
2007 Ms. Malena Rone, graduate student, won the annual Student Research Days Competition & Exposition for the paper entitled “Targeting and Insertion of the Cholesterol Binding Translocator Protein into the Outer Mitochondrial Membrane”.
2008 Ms. Malena Rone, graduate student, won a Travel Award to Endocrine Society annual meeting from the Division of Endocrinology; McGill University for her paper entitled “A two-step process in targeting and insertion of the cholesterol-binding Translocator Protein (18-kDa) into the outer mitochondrial membrane”.
2008 Ms. Malena Rone, graduate student, won a Travel Award to the “Symposium of the Réseau Québécois en Reproduction”, Quebec City, Canada.
2009 Dr. Andrew Midzak, post-doctoral fellow, received a CIHR training scholarship from the CIHR-Drug Development Training Program (TGF36110) for the project entitled: “Understanding the Mechanistic Role of the Cholesterol Recognition Amino Acid Consensus (CRAC) Domain of Translocator Protein (18-kDa; TSPO) and the STAR-related Lipid Transfer Domain (START) of the Steroidogenic Acute Regulatory Protein in Steroidogenesis”.
2010 Ms. Jiehan Li, graduate student, received a CIHR training scholarship from the CIHR-Drug Development Training Program (TGF36110) for the project entitled: “Steroidogenesis in adipocytes: relationship to adipocyte function and pharmacological modulation”. Her scholarship was renewed in 2011.
2010 Dr. Daniel Martinez–Arguelles, postdoctoral fellow, won a Travel Award from the organizing committee of the XIV Adrenal Cortex Conference to attend a present his work entitled “In Utero exposure to di-(2-ethylhexyl) phthalate affects the adrenal potassium channel expression leading to reduced circulating aldosterone levels in the adult” at the meeting held on June 16-18, San Diego, CA, USA.
2010 Dr. Daniel Martinez–Arguelles, postdoctoral fellow, won the Endocrine Society Outstanding Abstract Award for his presentation entitled “In Utero exposure to di-(2-ethylhexyl) phthalate affects the adrenal potassium channel expression leading to reduced circulating aldosterone levels in the adult” presented at the 92nd annual meeting of the Endocrine Society, June 19-22, San Diego, CA, USA.
2010 Dr. Andrew Midzak, post-doctoral fellow, received a competitive renewal of a CIHR training scholarship from the CIHR-Drug Development Training Program (TGF36110) for the project entitled: “Understanding the Mechanistic Role of the Cholesterol Recognition Amino Acid Consensus (CRAC) Domain of Translocator Protein (18-kDa; TSPO) and the STAR-related Lipid Transfer Domain (START) of the Steroidogenic Acute Regulatory Protein in Steroidogenesis”.
2011 Dr. Malena Rone, post-doctoral fellow, received a Trainee Scholarship Award from the Centre for the Study of Reproduction for work on the identification of the mechanisms underlying cholesterol import into mitochondria in steroidogenic Leydig
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cells.
2011 Dr. Andrew Midzak, postdoctoral fellow, received a two year postdoctoral fellowship by the Fonds de la recherche en santé de Québec (FRSQ) for the project entitled: “Identification d'un nouveau médicament contrôlant l'incorporation du cholestérol dans la mitochondrie et la biosynthèse des stéroïdes”.
2011 Ms. Jiehan Li, graduate student in Dr. Papadopoulos’ lab, won a Travel Award from the CIHR-Drug Development Training Program (TGF36110) to present her work on the ability of adipocytes to synthesize de novo steroids at the Endocrine Society Annual Meeting in Boston, MA, USA.
2011 Ms. Yasaman Aghazadeh, graduate student, received a competitive Research Institute of the MUHC training scholarship for the project entitled: “Role of the 14-3-3 adaptor proteins in hormone-induced testis Leydig cell steroid formation”.
2011 Dr. Malena Rone, post-doctoral fellow, received a competitive Research Institute of the MUHC training fellowship for the project entitled: “Role of the Translocator Protein (TSPO, 18kDa) in cancer cell heme production”.
2011 Mr. Rohan Pirangute, graduate student, won Best Presentation Award at the Bio-Connect Annual Biotechnology meeting, Montreal, Quebec, Canada for his presentation entitled “Targeting cholesterol recognition domain in translocator protein (18-kDa)-mediated cancer cell growth”
2011. Mr. Jonathan Madriaga, graduate student, won Best Presentation Award at the Bio-Connect Annual Biotechnology meeting, Montreal, Quebec, Canada for his presentation entitled “Generating a steroidogenic model as a tool for investigating age-related deficits in men”.
2011 Ms. Sathvika Jagannathan, graduate student, was awarded the Provost Graduate Fellowship for studies in the Experimental Medicine Graduate program, McGill University, January 2011, $6000.
2012 Ms. Sathvika Jagannathan, graduate student, was awarded the Graduate Excellence Fellowship from the Experimental Medicine Graduate program in recognition of her performance.
2012 Ms. Yasaman Aghazadeh, graduate student, received a Travel Award from the Centre for the Study of Reproduction to present her work at the Endocrine Society meeting at Houston, USA.
2012 Ms. Yasaman Aghazadeh, graduate student, received a Trainee Scholarship Award from the Centre for the Study of Reproduction for her work on the role of 14-3-3 family of proteins in Leydig cell function.
2012 Dr. Enrico Campioli, post-doctoral fellow, received a competitive Research Institute of the MUHC training fellowship for the project entitled: “In utero exposure to Di-(2-ethylhexyl) phthalate (DEHP) alters adipose tissue development.”
2012 Ms. Yasaman Aghazadeh, graduate student, received a competitive renewal of the Research Institute of the MUHC training scholarship for the project entitled: “Role of
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the 14-3-3 adaptor proteins in hormone-induced testis Leydig cell steroid formation”.
2012 Ms. Sathvika Jagannathan, graduate student, received a Trainee Scholarship Award from the Centre for the Study of Reproduction for her work on the reconstitution of functional cholesterol import machinery in vitro.
2013 Dr. Monica Sakai, post-doctoral fellow, won a NIH Trainee Travel Award from the American Society of Andrology to present her work on the ability of prostate cells to form steroids at the annual meeting of the Society at San Antonio, Texas, USA.
2013 Ms. Yasaman Aghazadeh, graduate student, won the best poster in Endocrinology and Metabolism at the annual symposium of the Experimental Medicine Graduate Program, McGill University for her presentation entitles “14-3-3ε is an outer mitochondrial membrane scaffold protein which regulates steroidogenesis by adapting the interactions of transduceosome components”.
2013 Dr. Leeyah Issop, postdoctoral fellow, won the Endocrine Society Outstanding Abstract Award for her presentation entitled “Role of ATAD3 in inter-organelle interactions in hormone-induced Leydig cell steroidogenesis” presented at the 95th annual meeting of the Endocrine Society, June 15-18, San Francisco, CA, USA.
2013 Dr. Andrew Midzak, postdoctoral fellow, received a one year postdoctoral fellowship by the Fonds de la recherche en santé de Québec (FRSQ) for the project entitled: “Identification d'un nouveau médicament contrôlant l'incorporation du cholestérol dans la mitochondrie et la biosynthèse des stéroïdes”.
2013 Mr. Tam Duong, undergraduate student, was awarded a RQR-CREATE Scholarship for summer internship.
2013 Ms. Jiehan Li, graduate student in Dr. Papadopoulos’ lab, won a Travel Award from the Réseau Québécois en Reproduction to present her work on the adipocyte sterol and steroid biosynthesis at the Congress in Steroid Research held on March 10-12, 2013, Chicago, IL, USA
2013 Ms. Jiehan Li, graduate student in Dr. Papadopoulos’ lab, won a Travel Award from the Centre for the Study of Reproduction (CSR) at McGill to present her work on the adipocyte sterol and steroid biosynthesis at the Congress in Steroid Research held on March 10-12, 2013, Chicago, IL, USA
2013 Dr. Enrico Campioli, postdoctoral fellow, received a competitive renewal of the Research Institute of the MUHC training fellowship for the project entitled: “In utero exposure to Di-(2-ethylhexyl) phthalate (DEHP) alters adipose tissue development.”
2013 Ms. Yasaman Aghazadeh, graduate student, received a competitive renewal of the Research Institute of the MUHC training scholarship for the project entitled: “Role of the 14-3-3 adaptor proteins in hormone-induced testis Leydig cell steroid formation”.
2014 Dr. Malena Rone, post-doctoral fellow, won a NIH Trainee Travel Award from the American Society of Andrology to present her work on the MA-10 Leydig cell mitochondrial metabolic activity in the regulation of steroid production at the annual meeting of the Society at Atlanta, GA, USA.
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2014 Dr. Leeyah Issop, post-doctoral fellow, won a NIH Trainee Travel Award from the American Society of Andrology to present her work on the role of ATAD3 in the hormone- induced ER-mitochondrial organization in hormone-induced Leydig cell steroidogenesis at the annual meeting of the Society at Atlanta, GA, USA.
2014 Dr. Leeyah Issop, post-doctoral fellow, won a Travel Award from the Réseau Québécois en Reproduction to present her work on the role of ATAD3 in the hormone- induced ER-mitochondrial organization in hormone-induced Leydig cell steroidogenesis at the annual meeting of the Society at Atlanta, GA, USA.
2014 Dr. Andrew Midzak, post-doctoral fellow, won a NIH Trainee Travel Award from the American Society of Andrology to present his work on non-steroidal ligands of the cholesterol recognition amino acid consensus (CRAC) motif of the 18-kDa translocator (TSPO) protein and their effects on steroid hormone biosynthesis at the annual meeting of the Society at Atlanta, GA, USA.
2014 Dr. Andrew Midzak, post-doctoral fellow, won a the Best Presentation Award from the American Society of Andrology for his work on non-steroidal ligands of the cholesterol recognition amino acid consensus (CRAC) motif of the 18-kDa translocator (TSPO) protein and their effects on steroid hormone biosynthesis presented at the annual meeting of the Society at Atlanta, GA, USA.
2014 Ms. Sathvika Jagannathan, graduate student, received the International Travel Award from the Division of Endocrinology & Metabolism to travel to the RIKEN Institute, Tokyo, Japan for training in methods of visualize cholesterol localization and movement in situ.
2014 Ms. Yasaman Aghazadeh, graduate student, won the award for the best presentation for her work entitled “Induction of androgen formation in the male by a peptide blocking 14-3-3ε protein adaptor and mitochondrial VDAC1 interactions” at the Centre for the Study of Reproduction annual meeting, Montreal, Quebec, Canada.
2014 Mr. Sunghoon Lee, graduate student, received a CIHR training scholarship from the CIHR-Drug Development Training Program (TGF36110) for the project entitled: Phthalate-induced predisposition to stressor drug response”.
2014 Ms. Sathvika Jagannathan, graduate student, was awarded the Center for the Study of Reproduction trainee fellowship to support her graduate studies.
2015 Dr. Enrico Campioli, postdoctoral fellow, received a Travel Award from the Centre for the Study of Reproduction (CSR) at McGill to present the results of his work on the cyclohexane-1, 2-dicarboxylic acid diisononyl ester (DINCH) and metabolite effects on rat epididymal stromal vascular fraction differentiation of adipose tissue at the Endocrine Society annual meeting, March 5-8, San Diego, CA, USA
2015 Ms. Yasaman Aghazadeh, postdoctoral fellow, received a Travel Award from the Centre for the Study of Reproduction (CSR) at McGill to present the results of her work on Translocator protein (TSPO) drug ligands induce testosterone formation in GnRH antagonist castrated rats. at Endocrine Society annual meeting, March 5-8, San Diego, CA, USA
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2015 Ms. Sathvika Jagannathan, graduate student, won a NIH Trainee Travel Award from the American Society of Andrology to present her work on the ability of prostate cells to form steroids at the annual meeting of the Society at Salt Lake City, Utah, USA.
2015 Ms. Nancy Li, a Pharmacology & Therapeutics undergardaute student won the PILS Graduate Award for Research Involvement.
2015 Mr. Sunghoon Lee, graduate student, received a Centre for the Study of Reproduction trainee fellowship to support his graduate studies.
2015 Ms. Nancy Li, a Pharmacology & Therapeutics undergardaute student won the best undergraduate student presentation award at the annual Centre for the Study of Reproduction meeting held on May 19, in Montreal.
2015 Dr. Enrico Campioli, postdoctoral fellow, received the International Travel Award from the Division of Endocrinology & Metabolism to present his results of his work on the global knockout and steroidogenic cell-targeted deletion of the translocator protein (18-kDa) unveil its crucial role in viability and hormone-dependent steroid formation, at the Endocrine Society annual meeting, March 5-8, San Diego, CA, USA
2015 Dr. Yasaman Aghazadeh, postdoctoral fellow, received the International Travel Award from the Division of Endocrinology & Metabolism to present the results of her work on Translocator protein (TSPO) drug ligands induce testosterone formation in GnRH antagonist castrated rats. at Endocrine Society annual meeting, March 5-8, San Diego, CA, USA
2015 Dr. Yasaman Aghazadeh, postdoctoral fellow, received the paper of the year award from the Division of Endocrinology & Metabolism for her paper entitled Induction of androgen formation in the male by a TAT-VDAC1 fusion peptide blocking 14-3-3ε protein adaptor and mitochondrial VDAC1 interactions, by Aghazadeh Y, Martinez-Arguelles DB, Fan J, Culty M, Papadopoulos V which appeared in Molecular Therapy (Nature), 2014, 22:1779-1791
2015 Ms. Nancy Li, a Pharmacology & Therapeutics undergradauate student won a RQR-CREATE program scholarship award for summer internship in our laboratory.
2015 Mr. Sunghoon Lee, graduate student, received a competitive Research Institute of the MUHC training scholarship for the project entitled: “In utero exposure to an environmentally relevant dose of DEHP targets the adrenal gland for endocrine disruption”.
2016 Dr. Enrico Campioli, postdoctoral fellow, received a Travel Award from the Centre for Research in Reproduction and Development (CRRD) at McGill to present the results of his work on the effect of prenatal exposure to 1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH) on offspring testicular function at the American Society of Andrology annual meeting, April 2-5, New Orleans, LA, USA.
2016 Dr. Enrico Campioli, postdoctoral fellow, received a Travel Award from the American Society of Andrology to present the results of his work on the effect of prenatal exposure to 1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH) on offspring testicular
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function at the American Society of Andrology annual meeting, April 2-5, New Orleans, LA, USA.
2016 Mr. Sunghoon Lee, graduate student, received a Travel Award from the Centre for Research in Reproduction and Development (CRRD) at McGill to present the results of his work entitled “In utero exposure to DEHP alters steroidogenesis in the adult male offspring: reversibility of the effects using pharmacological means” at the American Society of Andrology annual meeting, April 2-5, New Orleans, LA, USA.
2016 Mr. Sunghoon Lee, graduate student, received a Travel Award from the American Society of Andrology to attend and present the results of his work entitled “In utero exposure to DEHP alters steroidogenesis in the adult male offspring: reversibility of the effects using pharmacological means” at the American Society of Andrology annual meeting, April 2-5, New Orleans, LA, USA.
2016 Mr. Sunghoon Lee, graduate student, received a Graduate Research Enhancement and Travel Awards (GREAT) from the Department of Biochemistry, McGill University, to cover travel expenses to attend and present the results of his work entitled “In utero exposure to DEHP alters steroidogenesis in the adult male offspring: reversibility of the effects using pharmacological means” at the American Society of Andrology annual meeting, April 2-5, New Orleans, LA, USA.
2016 Ms. Sathvika Venugopal, graduate student, received a Travel Award from the American Society of Andrology to present the results of his work entitled “Identification of the source of cholesterol used for steroid biosynthesis in primary rat Leydig cells” at the American Society of Andrology annual meeting, April 2-5, New Orleans, LA, USA.
2017 Ms. Sathvika Venugopal, graduate student, received the NIH Travel Award from the American Society of Andrology to present the results of his work entitled “Dynamic subcellular lipid organization in hormone induced MA-10 mouse tumor Leydig cells” at the American Society of Andrology annual meeting, April 22-25, Miami, Florida, USA.
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SCHOLARSHIP AND RESEARCH: RESEARCH INTERESTS Dr. Papadopoulos’ research focuses on understanding the cellular and molecular mechanisms responsible for the initiation and maintenance of steroid biosynthesis in the adrenal, gonads and brain, in health and disease. He also examines the regulation of steroid biosynthesis, intracellular compartmentalization and homeostasis by hormones, chemicals, drugs, natural products and environmental factors. His goal is to understand the pathophysiology of steroidogenesis and develop new tools for the treatment of diseases related to elevated or low steroid levels or alter subcellular steroid compartmentalization as a means to block disease acquisition and/or progression. In these studies his laboratory is using biochemical, pharmacological and molecular methods as well animal models of disease and human biopsies and specimens to identify the physiological role of critical components of the steroidogenic pathway and pathological situations created by changes in the expression of these components in animals and humans. Drug design methods and molecular modeling are used by his laboratory to modify existing chemical entities and generate novel ones targeted at key elements of the steroidogenic machinery. Dr. Papadopoulos’ research has direct applications in reproduction and development, cancer, stress-related disorders, aging and brain related dysfunction, such as Alzheimer’s disease pathology, and infectious diseases, such as HIV. Dr. Papadopoulos has published more than 300 articles and holds numerous patents presented below. His work has been cited over 18,000 times (h-index = 71) based on source items indexed within Web of Science (ISI Web of Knowledge SM) and Google Scholar. Applications of the findings from Dr. Papadopoulos’ research in Reproductive Biology, Endocrinology, Neurosciences, Pathology, Environmental Toxicology, Aging, Breast Cancer and HIV therapy have been and are supported by grants and contracts from the National Institutes of Health, the National Science Foundation, Private Foundations, the US Department of Defense, the Canadian Foundation of Innovation, the Canadian Institutes of Health Research, as well as the Pharmaceutical and Biotechnology Industries. A. Research Grants: Past:
1989-1991 Equine placental aromatase: a different model of aromatization Funded by the Association for Cancer Research (ARC), France. Amount: $40,000 (for supplies only). Principal Investigator: Dr. P. Silberzahn Co-Principal Investigator: Dr. V. Papadopoulos 1989-1992 Cell biology of the testis Funded by the Andrew W. Mellon Foundation. Amount: $300,000. Principal Investigator: Dr. M. Dym
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Co-Investigator: Dr. V. Papadopoulos 1990-1991 Calcium-binding proteins in the regulation of steroid biosynthesis Funded by the National Institutes of Health grant # BRSG-RR-05360 to
Georgetown University School of Medicine. Amount: $25,000 (for supplies only). Principal Investigator: Dr. V. Papadopoulos 1991 Neurosteroids: biosynthesis and regulation Funded by the FIDIA Research Foundation Amount: $21,000 covering salary expenses. Principal Investigator: Dr. V. Papadopoulos 1991-1993 Mechanisms of regulation of cholesterol transport Funded by the National Institutes of Health (Shannon award) Grant No. R55-DK43358 Amount: $80,000 (direct cost). Principal Investigator: Dr. V. Papadopoulos 1991-1995 Mechanisms of regulation of cholesterol transport in steroidogenic cells Funded by the National Science Foundation Grant No. DCB-9017752 Amount: $150,000 (direct cost). Principal Investigator: Dr. V. Papadopoulos 1991-1995 Basement membrane regulation of Sertoli cells Funded by the National Institutes of Health Grant No. RO1-HD16260 Amount: $300,000 (direct cost). Principal Investigator: Dr. M. Dym Co-Investigator: Dr. V. Papadopoulos 1992-1995 Intratesticular regulation of Leydig cell function Funded by the National Institutes of Health Grant No. PO1-HD24633 Part of Program Project "Cell biology of the testis"; P.I.: Dr. M. Dym Project Amount: $221,289 (direct cost). Project Director: Dr. V. Papadopoulos. 1993-1995 Paracrine regulation of Leydig cell steroidogenesis Funded by the Rockefeller Foundation Amount: $70,000 Principal Investigator: Dr. V. Papadopoulos This grant covers expenses (salary and supplies) for a research fellow. 1993-1998 Research Career Development Award
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Intratesticular Regulation of Leydig Cell Function Funded by the National Institutes of Health Grant No. K04-HD01031 Amount: $312,500 (direct cost). Principal Investigator: Dr. V. Papadopoulos. 1994-2004 Effect of EGb 761 and Ginkgolides on the Endocrine Status of the Rat Funded by the Institute Henri Beaufour – IPSEN - SCRAS Amount: $830,000 (Direct Cost); 20% IDC. Principal Investigator: Dr. V. Papadopoulos. 1995-1996 Characterization of a 21,000 Mr steroidogenesis inhibitor intragonadal
protein Funded by the CONRAD program Amount: $15,000 (direct cost) Principal Investigator: Dr. V. Papadopoulos. 1995-1998 Role of benzodiazepine receptor in Leydig cell function Funded by the National Institutes of Health Grant No. ES-07447 Amount: $308,482 (direct cost) Principal Investigator: Dr. V. Papadopoulos 1995-1998 Neurosteroids: synthesis and regulation Funded by the National Science Foundation Grant No. IBN-9409551 Amount: $170,000 (direct cost) Principal Investigator: Dr. V. Papadopoulos 1996-1997 Peripheral benzodiazepine receptor in human breast cancer Funded by the National Institutes of Health National Cancer Institute SPORE grant (2P50-CA58185) to Lombardi Cancer
Center Amount: $40,000 (direct cost) Principal Investigator: Dr. V. Papadopoulos 1997-1998 Characterization of Novel PBR Ligands Funded by Taisho Inc., Tokyo, Japan Amount: $40,000 (direct cost). Principal Investigator: Dr. V. Papadopoulos. 1997-1999 PBR in Human Breast Cancer: Regulation by Ginkgolides Funded by SCRAS, Paris, France Amount: $124,000 (Direct Cost); 25% IDC. Principal Investigator: Dr. V. Papadopoulos.
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1998 Bioactivity of Novel PBR Ligands Funded by Athena Neurosciences Inc., CA, USA Amount: $3,500 (Direct Cost). Principal Investigator: Dr. V. Papadopoulos. 1998-1999 Mitochondrial Oxidation Funded by JenaPharm, Jena, Germany Amount: $24,000 (Direct Cost); 25% IDC. Principal Investigator: Dr. V. Papadopoulos. 1998-1999 Development of an Assay for DNA Damage In Situ Funded by the National Institutes of Health Grant No. ES-09464 (SBIR) to Trevigen Inc. Amount: $91,040 (Direct Cost) Principal Investigator: Dr. P. Vanek Subcontract to Dr. V. Papadopoulos, GUMC Amount: $12,000 (Direct Cost); 20% IDC 1998-2000 ANTICORT in Transgenic Mice Simulating Retinitis Pigmentosa Pathology Funded by the Steroidogenesis Inhibitors, Inc., Las Vegas, NV. Amount: $32,000 (Direct Cost); 25% IDC Principal Investigator: Dr V. Papadopoulos 1999-2000 Peripheral Benzodiazepine Receptor in Human Breast Cancer Funded by the National Institutes of Health Grant No. R21 CA-80763 Amount: $147,000 (Direct Cost); 57% IDC Principal Investigator: Dr. V. Papadopoulos 1998-2002 Role of Benzodiazepine Receptor in Leydig Cell Function Funded by the National Institutes of Health Grant No. ES-07447 Amount: $682,243 (Direct Cost); 57% IDC Principal Investigator: Dr. V. Papadopoulos 1998-2001 Role of Benzodiazepine Receptor in Leydig Cell Function (Supplement) Funded by the National Institutes of Health Grant No. R01 ES-07447 Amount: $150,000 (Direct Cost); 57% IDC Principal Investigator: Dr. V. Papadopoulos 1998-2001 Neurosteroids: Synthesis and Regulation Funded by the National Science Foundation Grant No. IBN-9728261 Amount: $170,000 (Direct Cost); 57% IDC Principal Investigator: Dr. V. Papadopoulos
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1998-2003 Acute Hormonal Regulation of Steroidogenesis Funded by the National Institutes of Health Grant No. 1R01 HD-37031 12/01/98-11/30/03 Amount: $822,052 (Direct Cost); 57% IDC Principal Investigator: Dr. V. Papadopoulos 1999-2004 The Regulation of Testicular Gonocyte Development Funded by the National Institutes of Health Grant No. 1R01 HD-37030 09/01/99-08/31/04 Principal Investigator: Dr. M. Culty Co-Investigator Dr. V. Papadopoulos Amount: $645,512 (Direct Cost); 57% IDC 1999-2004 Effect of the Ginkgo Biloba Extract EGb 761 in Cell Growth Funded by SCRAS, Paris, France Amount: $279,000 (Direct Cost); 25% IDC. Principal Investigator: Dr. V. Papadopoulos. 1999-2002 Role of Synthetic Steroids in Testicular Aging Funded by JenaPharm, Jena, Germany Amount: $40,000 (Direct Cost); 25% IDC. Principal Investigator: Dr. V. Papadopoulos. 1999-2003 Benzodiazepine Receptor and Adrenal Development Funded by the National Institutes of Health Grant No. 1R01 DK-55793 Principal Investigator: Dr. E. Widmaier, Boston University Subcontract to Dr. V. Papadopoulos, GUMC Amount: $116,000 (Direct Cost); 57% IDC 2000 In Vitro and In Vivo Studies on the Effect of Anticort on Adrenal
Glucocorticoid Biosynthesis Funded by the Steroidogenesis Inhibitors, Inc., Las Vegas, NV Amount: $31,400 (Direct Cost); 25% IDC Principal Investigator: Dr. V. Papadopoulos 2000-2003 Peripheral Benzodiazepine Receptor in Human Breast Cancer Funded by the Department of Defense Grant No. DAMD17-99-1-9200 Amount: $210,000 (Direct Cost); 57% IDC Principal Investigator: Dr. V. Papadopoulos 2001 Integrated Curriculum in Complementary and Alternative Medicine
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CIRCLE Grants program by Georgetown University School of Medicine Amount: $25,000 (Direct Cost) Principal Investigators: Drs. V. Papadopoulos & A. Haramati 2001-2003 Beneficial Effects of Gingko biloba in Cancer Funded by the National Institutes of Health Grant No. 1R21-AT00359 Amount: $250,000 (Direct Cost); 56% IDC Principal Investigator: Dr. V. Papadopoulos 2001-2004 Diagnosis and Treatments for Neurodegeneration and other Aging Related
Disorders Funding from Samaritan Pharmaceuticals Inc. to support a Drug Discovery
Research Laboratory at Georgetown University Amount: $1,500,000 (Direct Costs), 30% IDC Principal Investigator: Dr. V. Papadopoulos 2001-2006 Educational Initiative in CAM Funded by the National Institutes of Health Grant No. 1R25-AT00419 Amount: $1,503,742 (Direct Cost); 8% IDC Principal Investigator: Dr. A. Haramati Co-Principal Investigator: Dr. V. Papadopoulos 2002-2003 Embryonic Origin of Male Reproductive Diseases Georgetown University Office of the Dean of Research Pilot Program Project Grant application Amount: $25,000 (Direct Costs) Principal Investigator: Dr. V. Papadopoulos 2002-2004 Effects of Roundup and its Ingredients on Leydig Cell Steroidogenesis Funded by Monsanto Co., St Louis, Mo Amount: $50,000 (Direct Cost); 30% IDC. Principal Investigator: Dr. V. Papadopoulos. 2002-2004 Neurosteroids: Synthesis and Regulation Funded by the National Science Foundation Grant No. IBN-0110711 Amount: $64,433 (Direct Cost); 55.2% IDC Principal Investigator: Dr. V. Papadopoulos 2002-2006 Role of Benzodiazepine Receptor in Leydig Cell Function Funded by the National Institutes of Health. Grant No. 1R01 ES-07747-10 Amount: $1,000,000 (Direct Cost); 57% IDC Principal Investigator: Dr. V. Papadopoulos
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2004-2006 SP004, a 1 Ligand with AchE Inhibition Properties Funded by the National Institutes of Health to Samaritan Pharmaceuticals with a
subcontract to Georgetown University Grant No. 1R41 AG024684 Amount: $100,000 (Direct Cost) Subcontract to Georgetown University: $46,154 (Direct Cost); 30% IDC Principal Investigator: Dr. L. Lecanu Co-Investigator: Dr. V. Papadopoulos 2004-2006 Plasma Diagnostic for Alzheimer’s Disease Pathology Funded by the National Institutes of Health to Samaritan Pharmaceuticals with a
subcontract to Georgetown University Grant No. 1R41 NS048688 Amount: $178,515 (Direct Cost) Subcontract to Georgetown University: $69,505 (Direct Cost); 30% IDC Principal Investigator: Dr. V. Papadopoulos 2004-2007 Molecularly Targeted Agents for Improved Breast Cancer Diagnosis Funded by the Department of Defense Grant No. BC030523 Principal Investigator: Dr. D. Bornhop, Vanderbilt University Subcontract to Dr. V. Papadopoulos, GUMC Amount: $20,289 (Direct Costs); 55.2% IDC 2004-2009 Acute Hormonal Regulation of Steroidogenesis Funded by the National Institutes of Health Grant No. 1R01 HD-037031-10 Amount: $1,012,500 (Direct Cost); 55.2% IDC; 8% IDC Foreign Institution Principal Investigator: Dr. V. Papadopoulos 2004-2009 Development of Novel Theragnostics Funding from Samaritan Pharmaceuticals Inc. to support a Drug Discovery
Research Laboratory Amount: $3,846,154 (Direct Costs), 30% IDC Principal Investigator: Dr. V. Papadopoulos 2005-2008 Fluorescence Activated Sensing Technology
Integrated Threat Management System Funded by the Department of Defense & Anteon Corporation Subcontract to Georgetown University
Amount: $1,500,000 (Direct Cost); 25% IDC Principal Investigator: Dr. V. Papadopoulos
Upon the departure of Dr. Papadopoulos from Georgetown University on July 2007 the award was transferred to another PI.
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2005-2008 Ginkgo biloba Extract in the Treatment of Human Breast Cancer Funded by the Suzan G. Komen Breast Cancer Foundation Grant No. BCTR0503496 Amount: $200,000 (Direct Cost); 25% IDC Principal Investigator: Dr. V. Papadopoulos 2005-2010 Fetal Origin of Male Reproductive Diseases Funded by the National Institutes of Health Grant No. 1R01 ES013495-01 Amount: $1,402,508 (Direct Cost) 55.2% IDC (Georgetown); 8% IDC Foreign Institution (McGill) Principal Investigator: Dr. V. Papadopoulos 2006-2008 Fetal Origin of Male Reproductive Diseases - supplement Funded by the National Institutes of Health Grant No. 1R01 ES013495-01A1S1 Amount: $117,583 (Direct Cost); 55.2% IDC Principal Investigator: Dr. V. Papadopoulos
Upon the departure of Dr. Papadopoulos from Georgetown University on July 2007 the award was terminated.
2006-2011 Aging and Leydig Cell Function Funded by the National Institutes of Health Grant No. 1R37 AG021092 Principal Investigator: Dr. B. R. Zirkin (Johns Hopkins University). Subcontract to McGill University Health Centre Amount: $380,000 (Direct Cost) 55.2% IDC (Georgetown); 8% IDC Foreign Institution (McGill) Principal Investigator: Dr. V. Papadopoulos 2006-2012 Role of Benzodiazepine Receptor in Leydig Cell Function Funded by the National Institutes of Health. Grant No. 1R01 ES-07747-12 Amount: $1,125,000 (Direct Cost) 55.2% IDC (Georgetown); 8% IDC Foreign Institution (McGill) Principal Investigator: Dr. V. Papadopoulos 2007-2010 General Clinical Research Center Funded by the National Institutes of Health. Grant No. 1M01 RR023942-01 Amount: $5,915,868 (Direct Cost); $6,951,668 (Total Cost) Principal Investigator: Dr. V. Papadopoulos
Upon the departure of Dr. Papadopoulos from Georgetown University on July 2007 the award was transferred to another PI.
2007-2008 Drug Discovery Laboratory and Experimental Therapeutics
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Funded by the Canadian Foundation of Innovation Amount: $1,000,000 (Direct Cost)
Principal Investigator: Dr. V. Papadopoulos 2007-2009 Delineating the senescence phenotype: New targets for anti-ageing therapy Funded by the Hellenic Republic Ministry of Development
Scientific and Technological Cooperation Program Amount: Euros 60,000 (Direct Cost) Principal Investigator: Dr. D. Kletsas Co- Investigator: Dr. V. Papadopoulos
2007-2014 Canada Research Chair (Tier I)
Funded by the Canadian Foundation of Innovation Amount: $1,400,000 (Direct Cost)
Principal Investigator: Dr. V. Papadopoulos 2008-2012 Center Grant for The Research Institute of McGill University Health Center
Funded by Le Fonds de la recherche en santé du Québec Amount: $18,800,000 (Direct Costs)
Principal Investigator: Dr. V. Papadopoulos 2009-2013 Steroid biosynthesis in benign prostate hyperplasia: Effect of Degarelix and
relationship to cell growth Funded by Ferring Pharmaceuticals Total: $225,000 (Direct Cost); 30% IDC
Principal Investigator: Dr. V. Papadopoulos 2009-2014 Impact of exposure to phthalates, their metabolites and green plasticizers on
male reproductive health TEAM Grant No. RHF100626 Funded by the Institute for Human Development, Child and Youth Health, Canadian Institutes of Health Research (CIHR)
Amount: $2,495,000 (Direct Cost) Principal Investigator: Dr. B. Robaire Co-Investigator: Papadopoulos 2010-2011 Do di-(2-ethylhexyl) phthalate-induced changes in steroid production affect
blood pressure in the adult rat? Funded by the Center for the Study of Reproduction, McGill University Amount: $10,000 (Direct Costs) Principal Investigator: Dr. V. Papadopoulos 2011-2013 Steroid biosynthesis in benign prostate hyperplasia: Effect of Degarelix and
relationship to cell growth Funded by the Networks of the National Centres of Excellence (NCE) MITACS Program matching industrial (Ferring) funding Total: $373,333 (Direct Cost)
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Principal Investigator: Dr. V. Papadopoulos 2011-2014 Clinical Research Partnership with Biopharmaceutical Industry
The Research Institute of McGill University Health Center Funded by Le Fonds de la recherche en santé du Québec Amount: $1,322,352 (Direct Cost) Principal Investigator: Dr. V. Papadopoulos
2014 Role of membrane lipid domains and inter-organelle trafficking in
cholesterol transport Funded by the RIKEN Advanced Science Institute, Wako, Saitama, Japan Amount: $10,520 (Direct Costs) Co-Principal Investigators: Drs. T. Kobayashi and V. Papadopoulos 2014 Blood-Based Diagnostic of Alzheimer’s Disease
Funded by Royal Victoria Foundation Amount: $50,000 (Direct Cost)
Principal Investigator: Dr. V. Papadopoulos 2008-2015 Translational Research and Intervention across the Lifespan
Funded by the Canada Foundation of Innovation, Large Scale Institutional Endeavors - Research Hospital Fund competition. Total: $99,988,343 (Direct Cost)
Principal Investigator: Dr. V. Papadopoulos 2010-2015 Acute Hormonal Regulation of Steroidogenesis
Funded by the Canadian Institutes of Health Research (CIHR) Grant No. 211033; MOP-102647 Amount: $759,497 (Direct Cost) Principal Investigator: Dr. V. Papadopoulos 2011-2015 Towards the Systems Medicine of Fatty Liver Disease
Funded by Le Fonds de la recherche en santé du Québec Innovative Strategic Program Development Initiative Amount: $1,400,000 (Direct Cost)
Principal Investigator: Dr. V. Papadopoulos 2011-2016 Fetal Origin of Endocrine Dysfunction: The Phthalate Model
Funded by the Canadian Institutes of Health Research (CIHR) Grant No. 231423; MOP-111131 Amount: $779,380 (Direct Cost) Principal Investigator: Dr. V. Papadopoulos Present:
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2009-2016 Drug Development Training Program Funded by the Canadian Institutes of Health Research (CIHR) Grant No. TGF-96110 Total: $1,789,998 (Direct Cost)
Principal Investigator: Dr. V. Papadopoulos 2010-present Phil Gold Chair in Medicine McGill University/McGill University Health Centre Chair Funded by the Montreal General Hospital Foundation Amount: $3,000,000 endowment Principal Investigator: Dr. V. Papadopoulos 2011-2016 Aging and Leydig Cell Function Funded by the National Institutes of Health Grant No. 1R37 AG021092 Principal Investigator: Dr. B. R. Zirkin (Johns Hopkins University). Subcontract to McGill University Health Centre Amount: $250,000 (Direct Cost) Principal Investigator: Dr. V. Papadopoulos 2012-2017 Exploration, Validation and Improvement of a Blood-Based Diagnostic of
Alzheimer’s Disease Funded by Richard and Edith Strauss Canada Foundation Amount: $1,000,000 (Direct Cost)
Principal Investigator: Dr. V. Papadopoulos 2012-2016 Center Grant for The Research Institute of McGill University Health Center
Funded by Le Fonds de la recherche en santé du Québec Amount: $17,753,404 (Direct Cost)
Principal Investigator: Dr. V. Papadopoulos 2013-2018 Structure, function and pharmacological regulation of the mitochondrial
Translocator protein (TSPO; peripheral benzodiazepine receptor) in cholesterol transport and steroid formation Funded by the Canadian Institutes of Health Research (CIHR)
Grant No. 285680; MOP-125983 Amount: $812,365 (Direct Cost) Principal Investigator: Dr. V. Papadopoulos 2014-2021 Canada Research Chair (Tier I)
Funded by the Canadian Foundation of Innovation Competitive renewal of the 2007-2014 funded Chair Amount: $1,400,000 (Direct Cost)
Principal Investigator: Dr. V. Papadopoulos 2015-2020 Translational Research and Intervention across the Lifespan
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Funded by the Canada Foundation of Innovation, Large Scale Institutional Endeavors - Research Hospital Fund competition. Institutional Operating Funds Total: $15,000,000 (Direct Cost)
Principal Investigator: Dr. V. Papadopoulos 2015-2016 Blood-Based Diagnostic of Alzheimer’s Disease Canadian Consortium on Neurodegeneration in Aging (CCNA) - CIHR
Total: $25,000 (Direct Cost) Principal Investigator: Dr. V. Papadopoulos 2016-2021 Translational Research and Intervention across the Lifespan
Funded by the Canada Foundation of Innovation, Large Scale Institutional Endeavors - Research Hospital Fund competition. Total: $15,000, 000 (Direct Cost) institutional operating funds
Principal Investigator: Dr. V. Papadopoulos
2016 Peptide-based Pharmacological Induction of Androgen Formation in Male Hypogonadism
Funded by IASO Biomed, Colorado, USA Total: $100,000 USD (Direct Cost); plus 30% indirects
Principal Investigator: Dr. V. Papadopoulos 2016-2021 Regulation of Steroid Hormone Biosynthesis
Funded by the Canadian Institutes of Health Research (CIHR) Grant (Funding Reference) No. 148659 Amount: $860,064 (Direct Cost) Principal Investigator: Dr. V. Papadopoulos 2016-2021 Fetal Origin of Endocrine Dysfunction: The Plasticizer Model
Funded by the Canadian Institutes of Health Research (CIHR) Grant (Funding Reference) No. 148688 Amount: $860,064 (Direct Cost) Principal Investigator: Dr. V. Papadopoulos 2016-2019 Renovations to the Montreal General Hosp Campus to improve innovation
related infrastructure facilities for research, training and commercialization. Funded by the Strategic Innovation Fund, Innovation Science and Economic
Development Canada and the Ministry of Education, Science and Innovation of Quebec.
Total: $8,572,812 Principal Investigator: Dr. V. Papadopoulos
B. Patents: (* indicates licensed patents) 1. Title: Triazol compounds for the reduction of steroid production
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Inventors: Andrew Midzak, Nagaraju Akula, Vassilios Papadopoulos Submitted: 2015/3/23; Patent office: US 62/136,729
2. Title: Therapeutics for the induction of endogenous steroidogenesis and methods associated with their identification * Inventors: Yassaman Aghazadeh, Jinjiang Fan, Vassilios Papadopoulos, Submitted: 2013/6/14; Patent office: US 61/834.993
6. Title: Use of Ginkgo extract for treating cancer which is characterized by an overexpression of peripheral-type benzodiazepine receptor protein * Inventors: Katy Drieu, Vassilios Papadopoulos Publication date: 2008/7/16; Patent office: EP; Patent number: 1200108
7. Title: Method of testing whether a tumor is susceptible to treatment with a ginkgo biloba extract or Ginkgolide B by testing whether the cancer is characterized by an over-expression of peripheral-type benzodiazepine receptor protein * Inventors: Katy Drieu, Vassilios Papadopoulos Publication date: 2007/12/12; Patent office: EP; Patent number: 1865319
8. Title: Use of spirostenols to treat mitochondrial disorders * Inventors: Laurent Lecanu, Laurent Tillement, Vassilios Papadopoulos, Wenguo Yao, Janet Greeson Publication date: 2008/3/5; Patent office: EP; Patent number: 1893219
33. Title: Method of stimulating steroidogenesis with alpidem * Inventors: Karl E Krueger, Vassilios Papadopoulos, Publication date: 1991/7/16; Patent office: US; Patent number: 5032595
D. Invited Lectures:
1987 "Role of cytoskeleton in the mechanism of action of ACTH" Department of Biochemistry, University Hospital of Caen, Caen, France
1988 "Paracrine regulation of Leydig cell function" International Symposium on Recent Advances in Male Reproduction, Hyderabad, India
1988 "Paracrine regulation of Leydig cell function" Department of Medicine, University of New South Wales, Sydney, Australia
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1989 "Cytoskeleton associated protein kinases: role in the mechanism of action of ACTH" National Institutes of Health, Bethesda, Endocrinology and Reproduction Research Branch, Bethesda, MD, USA
1989 "Cytoskeleton associated ACTH binding proteins: Role in signal transduction" National Institutes of Health, Bethesda, Neuroendocrinology Research Branch, Bethesda, MD, USA
1989 "Cell biology of steroidogenic cell responses to hormones" Department of Anatomy and Cell Biology, Georgetown University School of Medicine, Washington, D.C., USA
1990 "The peripheral-type benzodiazepine receptor: cell biological role and pharmacological significance" "Transmitter Amino Acid Receptors" Symposium, Royal Society Meeting, London, UK
1990 "Mechanisms of regulation of cholesterol transport: role of mitochondrial benzodiazepine receptor" Department of Biology, Boston University, Boston, MA, USA
1990 "Role of DBI and its processing products at peripheral-type benzodiazepine receptors: stimulation of steroid biosynthesis" International meeting on Diazepam Binding Inhibitor, FIDIA-Georgetown Institute for the Neurosciences, Georgetown University, Washington, D.C., USA
1991 "Mitochondrial Benzodiazepine Receptors: Structure and Function in CNS and Peripheral Organs” Symposium, 5th World Congress of Biological Psychiatry, Florence, Italy
1991 "Regulation of glial cell steroid biosynthesis by benzodiazepines" Neurosteroids and Brain Function, Satellite meeting of the 1991 Neuroscience meeting, New Orleans, LA, USA
1991 "Mitochondrial benzodiazepine receptor: a new piece in the puzzle of steroid biosynthesis" Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
1992 "Novel aspects of the regulation of steroid biosynthesis" State-of-the-Art Lecture, American Society of Andrology, Annual Meeting, Washington, D.C., USA
1992 "Molecular mechanisms involved in the regulation of steroid biosynthesis" Novel Actions of Steroids, Satellite meeting of the 1992 Neuroscience meeting, Anaheim, CA, USA
1993 "Role of a benzodiazepine receptor in steroidogenesis. From testis and adrenal to brain" The Population Council, Center for Biomedical Research, New York, NY, USA
1993 "Role of a benzodiazepine receptor in steroidogenesis". Mayo Clinic Jacksonville, Jacksonville, Florida, USA
1993 "Cholesterol-linked phosphorothioated oligodeoxynucleotides: synthesis and application" Laboratory of Immunology, National Institute of Dental Research, National Institute of Health, Bethesda, MD, USA
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1993 "Role of calpactins in steroidogenesis". International Meeting on Emerging Roles of Cytoskeleton in Reproductive Endocrinology, National Institutes of Health, Bethesda, MD, USA
1993 "Novel aspects of steroid formation". Grand Rounds, Department of Obstetrics and Gynecology, Georgetown University Medical Center, Washington, D.C., USA
1994 "Role of a benzodiazepine receptor in steroidogenesis" National Institutes of Health, Bethesda, Endocrinology and Reproduction Research Branch, Bethesda, MD, USA
1994 "Role of the mitochondrial peripheral-type benzodiazepine receptor in the regulation of steroid biosynthesis". Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
1994 "Peripheral-type benzodiazepine receptor in steroid biosynthesis: from testis to adrenal to brain". Department of Biochemistry, University of Caen Medical Center, Caen, France.
1994 "Peripheral-type benzodiazepine receptor in steroid biosynthesis: from testis to adrenal to brain". Department of Cell Biology, Pierre & Marie Curie University, Paris, France.
1994 "Peripheral-type benzodiazepine receptor in steroid biosynthesis: from testis to adrenal to brain". Institute of Biochemistry, Odense University, Odense, Denmark.
1994 "Peripheral-type benzodiazepine receptor in steroid biosynthesis: from testis to adrenal to brain". Department of Protein Chemistry, Elf-BioRecherches, Labege, France.
1994 "Peripheral-type benzodiazepine receptor in steroid biosynthesis: from testis to adrenal to brain". Division of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
1994 "Acute regulation of steroidogenesis by hormones” Division of Developmental Biology, NIMH, National Institutes of Health, Bethesda, MD, USA.
1994 "Peripheral-type benzodiazepine receptor and steroidogenesis". XI International Congress on Hormonal Steroids, Dallas, TX, USA.
1995 "Peripheral-type benzodiazepine receptor in steroid biosynthesis: from testis to adrenal to brain" Department of Anatomy and Cell Biology, Tufts University, School of Medicine, Boston, MA, USA
1995 "Role of the peripheral-type benzodiazepine receptor in steroidogenesis", Department of Pharmacology, University of Wisconsin, Madison, WI, USA
1995 "Diazepam Binding Inhibitor and peripheral-type benzodiazepine receptors: Role in steroid biosynthesis", 1995 American Testis Workshop, Raleigh, NC, USA
1995 "Growth factors, steroids and testicular function", Conference on "Hormones and growth factors in development and neoplasia", Fogarty International Center, National Institutes of Health, MD, USA
1995 "Role of the peripheral-type benzodiazepine receptor in steroidogenesis", Institute Henri Beaufour-IPSEN, Paris, France
1995 "Regulation of steroidogenesis by EGB 761 and Ginkgolides A and B", Institute Henri Beaufour-IPSEN, Paris, France
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1995 "Role of the peripheral-type benzodiazepine receptor in steroidogenesis", Laboratoire de Biochimie des Regulations Cellulaires Endocrines, INSERM U244, Centre des Études Nucléaires de Grenoble, Grenoble, France
1995 “Identification of a stimulator of steroid hormone synthesis from testis” Department of Obstetrics & Gynecology, University of Maryland, MD, USA
1996 "Peripheral-type benzodiazepine receptor in steroid biosynthesis: from testis to adrenal to brain" Department of Pharmacology, Georgetown University Medical Center, Washington, DC, USA
1996 “Role of the peripheral-type benzodiazepine receptor in steroidogenesis” 2nd International Symposium on Molecular Steroidogenesis, Monterey, California, USA
1996 “Benzodiazepine receptors in steroidogenesis” International Congress of Endocrinology, San Francisco, USA
1996 "Growth factors and Leydig cell function” 1st International Meeting of Biology and Pathology on Male Reproduction, Madrid, Spain
1996 "Novel aspects of the regulation of Leydig cell function” 1st International Meeting of Biology and Pathology on Male Reproduction, Madrid, Spain
1996 "Regulation of adrenal, gonadal, and brain steroidogenesis” Institute Henri Beaufour-IPSEN, Paris, France
1996 “Structure and function of the peripheral benzodiazepine receptor” Synthelabo Recherche Inc., Paris, France
1996 “Structure and function of the peripheral benzodiazepine receptor” INSERM, University of Rennes, Rennes, France
1996 "Peripheral-type benzodiazepine receptor in steroid biosynthesis: from testis to adrenal to brain” INRA, Reproductive Biology Section, Noujilly, France
1996 “Ginkgolides regulate the peripheral benzodiazepine receptor and steroidogenesis” Recent Advances in Ginkgo Biloba Research Conference, Ottrot, France.
1997 “Mechanisms of neurosteroid synthesis” Philippe Laudat Conference, Paris, France.
1997 “Neurosteroids and the peripheral benzodiazepine receptor” European College of Neuropsychopharmacology, Vienna, Austria
1997 “Mechanism of action of ginkgolides” Recent Advances in Ginkgo Biloba Research Conference, Périgord, France
1997 “Role of the peripheral benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis” Martin-Luther-Universitat, Halle-Wittenberg, Germany
1997 “Regulation of testicular, adrenal, and brain steroidogenesis: In search of the elusive trigger” Department of Pharmacology, University Paris XII, Paris, France
1997 “Regulation of peripheral benzodiazepine receptor expression by peroxisome proliferators” Mid-Atlantic Meeting on Reproductive Biology, Georgetown University, Washington DC, USA
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1997 “Peripheral benzodiazepine receptors: structure and function in steroidogenesis” Animal Reproduction and Biotechnology Laboratories, Colorado State University, Fort Collins, Colorado, USA
1997 “Regulation of glucocorticoid synthesis by the Ginkgo Biloba extract EGb 761 and isolate ginkgolides” Second International Conference on Cortisols and Anti-Cortisols” Las Vegas, Nevada, USA
1998 “Mechanisms of cholesterol uptake by mitochondria” Endocrine Society Annual Meeting, New Orleans, USA
1998 “Peripheral benzodiazepine receptor: a solo or a team player in steroidogenesis?” Xth International Congress on Hormonal Steroids, Quebec City, Canada
1998 “Regulation of cholesterol transport in steroidogenic cells” The Adrenal Cortex Conference, Orford, Quebec, Canada
1998 “Peripheral benzodiazepine receptor in steroidogenesis” XIIth Ovarian Workshop, Houston, Texas, USA
1998 “Neurosteroids: Synthesis and Regulation” College de France, Paris, France
1998 "Effect of ginkgolides in steroid biosynthesis” Institute Henri Beaufour-IPSEN, Paris, France
1998 “Peripheral-type benzodiazepine receptor: structure and function” Athena Neuroscience Inc., San Francisco, CA, USA
1999 “Peripheral benzodiazepine receptor: from testis to adrenal to brain” Department of Cell Biology and Neurobiology, University of South Carolina, Medical School, SC, USA
1999 “Peripheral benzodiazepine receptor in gonadal, adrenal and brain steroid synthesis” Uniformed Services University of Health Sciences, MD, USA
1999 “Structure and function of the peripheral-type benzodiazepine receptor” Banting and Best Institute, University of Toronto, Toronto, Canada
1999 “Neurosteroid biosynthesis and regulation in the human brain” 3nd International Symposium on Molecular Steroidogenesis, Nara, Japan
1999 “Peripheral benzodiazepine receptor and cholesterol in human breast cancer” Polish Anatomical Society and Polish Society of Histochemistry and Cytochemistry, Lotz, Poland
1999 "In search of the ginkgolide-activated receptor” Institute Henri Beaufour-IPSEN, Paris, France
1999 “Peripheral benzodiazepine receptor in human breast cancer” Institute Henri Beaufour-IPSEN, Paris, France
1999 “-amyloid-induced neurotoxicity: role of antioxidants” Jenapharm Inc., Jena, Germany
1999 “Role of peripheral benzodiazepine receptor and SF-1 in steroidogenesis” Jenapharm Inc., Jena, Germany
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1999 “Structure and function of the peripheral-type benzodiazepine receptor (PBR) and PBR associated proteins”, Department of Cell Biology and Biochemistry, Texas Tech Health Sciences Center, Lubbock, Texas, USA
1999 “PBR-mediated cholesterol compartmentalization and function in gonads, adrenal, brain and breast” Department of Pharmacology, University Paris XII, Paris, France
1999 “PBR in cholesterol transport and steroidogenesis” (presentation via videoconference) 18th meeting of the Society for Reproductive Biology & Comparative Endocrinology, Symposium on “Endocrine Update Towards Next Millennium”, Madras Christian College, Chennai, India
2000 “Structure and function of the peripheral-type benzodiazepine receptor (PBR) and PBR associated proteins”, Department of Biochemistry, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA
2000 “Structure and function of the peripheral-type benzodiazepine receptor (PBR) and PBR associated proteins”, Department of Physiology, Morehouse School of Medicine, Atlanta, GA, USA
2000 “Role of the peripheral-type benzodiazepine receptor (PBR) in steroidogenesis”, 14th Rappaport Symposium on The Molecular Biology of Neuropsychiatric Diseases, Haifa, Israel
2000 “Peripheral-type benzodiazepine receptor: regulation and triggering of an ubiquitous lipophorin” Martin-Luther-Universitat, Halle-Wittenberg, Germany
2000 “Peripheral-type benzodiazepine receptor: structure and function and of an ubiquitous lipophorin” University of Dusseldorf, Dusseldorf, Germany
2000 “Peripheral-type benzodiazepine receptor: regulation and triggering of an ubiquitous lipophorin” INSERM, Hospital Bichat, Paris, France
2000 “Anticancer properties of a Gingko biloba extract” Comprehensive Cancer Care Conference, Crystal City, Arlington, VA, USA
2000 “Regulation of mitochondrial steroid synthesis by molecules acting at the permeability transition pore” VIth Mediterranean Congress of Clinical Pharmacology, Tunis Carthage, Tunisia
2001 “Peripheral-type benzodiazepine receptor: regulation and triggering of an ubiquitous lipophorin” Department of Physiology, University of Illinois at Chicago, Chicago, IL, USA
2001 “Peripheral-type benzodiazepine receptor: structure and function and of an ubiquitous lipophorin” The Population Council, Center for Biomedical Research, Rockefeller University, New York, NY, USA
2001 “Peripheral-type benzodiazepine receptor: a cholesterol-binding protein” Mid-Atlantic Meeting of Reproductive Biology, University of Virginia, Charlottesville, VA, USA
2001 “Peripheral benzodiazepine receptor and cholesterol delivery” Endocrine Society Annual Meeting, Colorado, USA
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2001 “Peripheral benzodiazepine receptor: structure, function and regulation by endocrine modulators of a cholesterol receptor” Chemical Industry Institute of Toxicology, North Carolina, USA
2001 “PAP7: a peripheral benzodiazepine receptor and protein kinase A associated protein” Unit on Genetics and Endocrinology, Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, MD, USA.
2002 “Peripheral benzodiazepine receptor: structure, physiological function, and involvement in cancer growth” Graduate School, University of Berlin, Germany
2002 “Peripheral benzodiazepine receptor: structure and function in health and disease” National Center for Scientific Research “Demokritos”, Athens, Greece
2002 “Neurosteroid synthesis in neurodegeneration: an oxidative stress mediated process.” 2002 World Congress on Oxidants and Antioxidants in Biology, Santa Barbara, CA, USA
2002 “PBR, StAR and PKA: partners in cholesterol transport” The Adrenal Cortex Conference, San Francisco, CA, USA
2002 “Intracellular cholesterol compartmentalization in health and disease. Role of PBR” International Congress on Hormonal Steroids and Hormones and Cancer. Fukuoka, Japan
2002 “Peripheral benzodiazepine receptor: structure and function of a lipophorin” Department of Biochemistry, Georgetown University Medical Center, USA
2002 "Identification of a ginkgolide-activated receptor response element” Institute Henri Beaufour-IPSEN, Paris, France
2002 “Peripheral benzodiazepine receptor: structure and function in health and disease” National Academy of Pharmacy, Paris, France
2002 “An unexpected effect of molecular biology: role of EGb 761 extract on the expression of genes involved in cell proliferation. A hope against cancer onsets or metastasis appearance.” Ginkgo biloba Conference: from traditional medicine to a medicine of the future, Berlin, Germany
2002 “Peripheral benzodiazepine receptor: structure and function in health and disease” Sumitomo Pharmaceuticals, Osaka, Japan
2002 “Novel methods for the detection and prevention of Alzheimer’s disease pathology” Innogenetics, Inc., Ghent, Belgium
2002 “Peripheral benzodiazepine receptor: a lipophorin in health and disease” Center for Research in Reproduction and Women’s Health, University of Pennsylvania, USA
2003 “Cytostatic properties of the Ginkgo biloba extract EGb 761 in human breast cancer” International Conference on Complementary and Alternative Medicine. University of California Irvine, Irvine, USA
2003 “Ginkgo biloba extracts in neurodegeneration and cancer: a drug supplement?” Interdisciplinary Program in Neurosciences, Georgetown University, Washington, DC, USA
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2003 “High cortisol diseases and therapies” Samaritan Pharmaceuticals, Las Vegas, NV, USA
2003 “Peripheral benzodiazepine receptor: structure and function of a cholesterol binding protein” Brazilian Federation of Experimental Biology, Curitiba, Brazil
2003 “Peripheral benzodiazepine receptor in human breast cancer” Department of Pathology, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
2003 “Neurosteroids: synthesis, regulation and function in neurodegeneration” Department of Pathology, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
2003 “Control of steroid synthesis in HIV and Alzheimer’s disease therapies: BioEurope 2003, Frankfort, Germany
2003 “Theragnostics in Alzheimer’s disease therapy” Department of Neurology, GUMC, Washington, DC, USA
2004 “Molecular and cellular mechanisms underlying endocrine disruption in Leydig cells” Bloomberg school of Public Health, Johns Hopkins University, Baltimore, MD, USA
2004 “Peripheral benzodiazepine receptor: structure and function of a cholesterol binding protein” Division of Endocrinology, Department of Medicine, GUMC, Washington, DC, USA
2004 “Peripheral benzodiazepine receptor in human cancer” Department of Biochemistry, University of Poitiers School of Medicine, Poitiers, France
2004 “Peripheral benzodiazepine receptor: structure and function of a cholesterol binding protein” University of Poitiers School of Sciences, Poitiers, France
2004 “Peripheral benzodiazepine receptor: the gatekeeper of cholesterol entry into mitochondria” Department of Pharmacology, GUMC, Washington, DC, USA
2004 “Peripheral benzodiazepine receptor: the gatekeeper of cholesterol entry into mitochondria” Unit on Genetics and Endocrinology, Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, MD, USA
2004 “Functional interaction of PBR and StAR in cholesterol transport and steroidogenesis” Adrenal Cortex Conference, New Orleans, USA
2004 “Structure and function of the peripheral-type benzodiazepine receptor” Vanderbilt Institute of Chemical Biology, Vanderbilt University, USA
2004 Peripheral benzodiazepine receptor: structure and function in health and disease” Winberg Medical Center, Johnstown, PA, USA
2004 “Structure and function of the peripheral-type benzodiazepine receptor” Novartis Inc., Basel, Switzerland
2004 “Novel steroid-based concepts and therapies for HIV and Alzheimer’s disease” Pharmaplaz Inc., Athlon, Ireland
2004 “Peripheral benzodiazepine receptor: structure and function in health and disease” Ecopia Biosciences Inc., Montreal, Canada
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2004 “Peripheral benzodiazepine receptor: from ligand binding to cholesterol transport. International symposium to rename PBR. December 16-17, Washington, DC, USA
2005 “Peripheral benzodiazepine receptor and neurosteroid biosynthesis in neurodegeneration” 3nd International meeting on Steroids and Nervous System. Torino, Italy
2005 “Application of morphological sciences in molecular and cellular biology” XVII International Symposium on Morphological Sciences. Belgrade, Serbia and Montenegro
2005 “Drug Development in Academia” National Capital Region Biomedical Engineering and Science Showcase organized by Virginia Tech, Wake Forest University and Partners, March 3-4, Bethesda, MD, USA
2005 “New methodology developed to optimize (spirostenol inhibition of amyloid-induced neurotoxicity) drug candidate selection” Computational Methods in Drug Design Symposium, April 3-6, Riva-San Vitale, Lugano, Switzerland
2005 “Hormonal regulation of steroid biosynthesis: in search of the elusive trigger” Department of Medicine, Georgetown University Medical Center, Washington, DC, USA
2006 “Formation of a macromolecular protein signaling complex in mitochondria: role in cholesterol transport and steroidogenesis” CHUL Research Centre and Department of Obstetrics and Gynecology, Faculty of Medicine, Laval University, March 23-24 Quebec City, Canada
2006 “Formation of a macromolecular protein signaling complex in mitochondria: role in cholesterol transport and steroidogenesis”. Adrenal Molecular Steroidogenesis Conference, June 20-23, Boston, MA, USA
2006 “Peripheral-type benzodiazepine receptors and neurosteroid production: a real perspective for new therapeutic neuroprotective strategies” International Workshop of the Neurex neurosciences research network of the Universities of Basel (Switzerland), Freiburg (Germany) and Strasburg (France). October 20, Strasburg, France.
2006 “Hormonal regulation of steroidogenesis: In search of the elusive trigger”. Department of Physiology & Biophysics, Georgetown University, Washington, DC, USA
2007 “Translocator Protein in Brain Function” Round Table on Steroids and Translocator protein at IV International Meeting on Steroids and the Nervous System, February 17-21, Villa Gualino, Turin, Italy
2007 “Hormonal regulation of steroidogenesis: In search of the elusive trigger”. Department of Pharmacology & Therapeutics, McGill University, February 15, Montreal, Quebec, Canada
2007 “Expression of steroidogenic proteins in germ cells; role in sperm function and fertility” American Society of Andrology Annual meeting, April 21-24, Tampa, Florida, USA
2007 “Challenges and Opportunities in Biomedical Research in the New Millennium” Mental Health and Addiction retreat of McGill University Health Center, March 30-April 2, Mont Tremblant, Quebec, Canada.
2007 “Future Directions in Medical Research” The University of West Indies, First Annual Research Day, April 20, Nassau, The Bahamas.
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2007 “Hormonal regulation of steroid biosynthesis: mechanisms, targets and drug development” Department of Medicine, McGill University, February 15, Montreal, Quebec, Canada
2007 “Hormonal regulation of steroidogenesis: In search of the elusive trigger”. Faculties of Medicine, Arts and Sciences, Sherbrook University, October 24, Sherbrook, Quebec, Canada
2007 “Hormonal regulation of steroidogenesis: In search of the elusive trigger”. Department of Anatomy and Cell Biology, McGill University, February 15, Montreal, Quebec, Canada
2007 “Alzheimer’s Disease therapy; what is in the pipeline?” Immunology Montreal Symposium, November 16, Montreal, Quebec, Canada
2008 “Neurosteroids in brain function and pathology” Department of Psychiatry, McGill University, January 11, Montreal, Quebec, Canada
2008 “Is there hope for Alzheimer’s disease therapy?” Grand Rounds, St Mary’s Hospital, Montreal, Quebec, Canada
2008 “Protein-protein interactions driving cholesterol transport in steroidogenic cell mitochondria”. Cellular Lipid Transport: Connecting Fundamental Membrane Assembly Processes to Human Disease, American Society of Biochemistry and Molecular Biology Meeting. Oct 29-Nov 2, 2008 Canmore Conference Center, Alberta, Canada
2008 “Translocator protein (18-kDa): a conserved mechanism of cholesterol transport in health and disease. Lady Davis Research Institute, Montreal, Quebec, Canada
2008 “Neurosteroids: synthesis, regulation and function in neurodegeneration” CHUL Research Centre Faculty of Medicine, Laval University, June 5, Quebec City, Canada
2008 “Neurosteroids in the treatment of neurodegeneration” EHRLICH II, 2nd World Conference on Magic Bullets, October 3-5, Nurnberg, Germany
2008 “Cholesterol transport in steroidogenic cells: mechanisms and function in health and disease” Larry Ewing Lecture in Reproductive Biology; Johns Hopkins University School of Public Health, Baltimore, MD, USA
2008 “NIH Peer-Review: a reviewer’s and grantee’s perspective”. ADARUQ (association of research administrators) Colloque, Orford, Quebec, Canada
2008 “Structure and function of translocator proteins TSPO families of proteins” INSERM, Hospital Bichat, Paris, France
2008 “Cholesterol transport in steroidogenic cells: mechanisms and function in health and disease” UPRES EA4312, University of Rouen, Evreux, France
2009 “Cholesterol transport in steroid biosynthesis: Role of protein-protein interactions and implications in disease states”. Dean’s Distinguished Lecture; Georgetown University Medical Center, Washington, DC, USA
2009 “Cholesterol transport in steroid biosynthesis: mechanisms and function in health and disease states”. Center for Research in Neurosciences, McGill University, Montreal, Quebec, Canada
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2009 “Translocator protein (18-kDa): a conserved mechanism of cholesterol transport in health and disease”. Royal Veterinary College, University of London, London, UK
2009 “Phthalate plasticizer induced endocrine disruption in the male”. Montreal Children’s Hospital, Montreal, Quebec, Canada.
2009 “Translocator protein (18-kDa): a conserved mechanism of cholesterol transport in health and disease. Society of Biochemistry, November 9-12, Tucuman, Argentina
2009 “Cholesterol transport in steroid biosynthesis: Role of protein-protein interactions and implications in disease states” Meakins Christie Laboratories, Montreal Chest Institute, McGill University, Montreal, Canada
2009 “Structural and functional evolution of the translocator protein TSPO” Gene families and Isozymes Conference, December 6-11, St Croix, Virgin Islands, USA
2010 “Cholesterol transport in steroid biosynthesis: mechanisms and function in health and disease”. Chinese University of Hong Kong, January 8, Hong Kong, China
2010 “Hormonal regulation of mitochondrial proteome; relationship to cholesterol transport and steroid biosynthesis” VI International Barbados proteomics conference, HUPO Workshop on Organellar Proteomics, January 8-15, Holetown, Barbados
2010 «Les Phthalates: conséquences chez l'adulte après dosage pendant le développement” Symposium on Environmental Reproductive Toxicology, 78th Congress of the Association Francophone pour le Savoir, May 2010, Montréal, Canada
2010 “Cholesterol transport in steroid biosynthesis: mechanisms and function in health and disease”. Rockefeller University, New York, NY, USA
2010 “The McGill University Health Centre redevelopment project: supporting the Best Care for Life” Forum of Grand Projects, Board of Trade of Metropolitan Montreal, QC, Canada
2010 “The steroidogenic cell mitochondria cholesterol import machinery”. Adrenal Cortex Conference. June 16-18, San Diego, CA, USA
2010 “Cholesterol transport in steroid biosynthesis: mechanisms and function in health and disease” Department of Pathology and Cell Biology, Université de Montréal, Montréal, QC, Canada
2010 “Challenges and opportunities in translational research in academia and pharmaceutical industry” Forum on Creative Partnerships in Biopharmaceutical Research, Montreal Board of Trade of Metropolitan Montreal, Canada
2010 “The role of academia in innovation and commercialization” Quebec Centre for Drug Development, Montreal, Canada
2010 “Medicine 2010: portable, personalized, informed” Roundtable on Medicine 2020. Institute for Strategic Analysis and Innovation, Montreal, Canada
2010 “Alzheimer’s Disease Drug Discovery” NeuroTalk 2010, June 25-28, Singapore, Declined.
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2010 “Caprospinol in Alzheimer’s disease therapy” Congress of International Drug Discovery Sciences and Technology, Section: Neurodegenerative Diseases October 23-26, Beijing, China, Declined.
2010 “How can we contribute to the growth of Greek academic science?” Panel member presenting at the Biotechnologia 2010 Conference, June 22-27, Sounio, Greece
2010 “Fetal origin of steroid biosynthesis dysregulation in the adult: environmental factors, epigenetics and organ interactions” Plenary Lecture. 14th International Congress on Hormonal Steroids and Hormones & Cancer. September 21-24, Edinburgh, Scotland, UK
2010 “The steroidogenic cell mitochondria cholesterol import machinery: from biology to the clinic” School of Molecular Biosciences, Washington State University, Pullman, WA, USA
2010 "Fetal origin of endocrine dysfunction: the phthalate plasticizer model" Endocrine rounds, McGill University Health Centre, Montreal, Quebec, Canada
2010 “Fetal origin of steroid biosynthesis dysregulation in the adult: environmental factors, epigenetics and organ interactions” Gene families and Isozymes Conference, December 5-10, Turks & Caicos Islands, British West Indies
2011 “Neuroactive steroid biosynthesis as the target pathway for neurotropic drug development. The Caprospinol story.” 6th International meeting on Steroids and Nervous System. February 19-23, Villa Gualino, Torino, Italy
2011 “Hormonal regulation of mitochondrial proteome; relationship to cholesterol transport and steroid biosynthesis” XXIth North American Testis Workshop, March 30-April 2, Montreal, Canada
2011 “Translocator protein: an emerging therapeutic target in neurotrauma” EPS Global International Forum on Neuroscience, July 9-11, Nanjing, Jiangsu, China
2011 “Foreseen applications of imaging MS in academia for cancer research” Clinical Proteomics Symposium, University of Montreal, McGill University & Genome British Columbia, September 9, Montreal, QC, Canada
2011 “Hormone-induced mitochondrial plasticity mediates steroid formation in Leydig cells” International symposium on mitochondrial research, Mitochondria Hub Regulation Research Center, Dong-A University, October 10-12, Busan, Korea
2011 “Neurosteroids in Alzheimer’s disease diagnosis and treatment” Symposium on recent progress and perspectives in Alzheimer’s disease, National Academy of Medicine, October 24, Paris, France
2011 "Challenges and opportunities in translational research in Academia and Pharmaceutical Industry” Réseau Québécois en Reproduction (RQR) Workshop on knowledge translation, RQR meeting November 14-16, Montreal, Canada
2011 “Discovery of a steroid drug candidate, Caprospinol, to treat Alzheimer’s disease based on the ability of brain to form steroids” 45th Annual Conference on Gene Families and Isozymes, December 4-9, St Croix, Virgin Islands, USA
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2012 “Identification of a dynamic mitochondrial protein complex driving steroidogenesis” 8th International Barbados Workshop, January 21-28, Holetown, Barbados
2012 “Bridging the gap with translational science: today and tomorrow” Meakins-Christie International Workshop, February 4-6, Vaudreuil, Canada
2012 “Innovative Medicine in the 21st Century” American Association of Health Centers International Forum, March 26-27, Washington DC, USA
2012 “Structure and function of the translocator protein TSPO” Department of Biochemistry & Molecular Biology, Michigan State University, March 8, East Lansing, MI, USA.
2012 “Structure and function of Translocator protein (18 kDa)” 28th Collegium International Neuro-Psychopharmacologicum CINP World Congress – June 3-7, Stockholm, Sweden
2012 “The role of research centers in bridging the gap with translational science: the vision of the RI MUHC” Prince Naif Health Research Center, King Saud University, June 16, Riyadh, Kingdom of Saudi Arabia.
2012 “The role of research centers in bridging the gap with translational science: the vision of the RI MUHC” King Fahad Specialist Hospital, June 17, Dammam, Kingdom of Saudi Arabia.
2012 “The cholesterol Odyssey to steroidogenic mitochondria via hormone-induced protein complex remodeling” Adrenal Cortex Conference. June 20-22, Houston, TX, USA
2012 “Fetal origin of endocrine disorders; the phthalate model” Center for Integrative Toxicology, Michigan State University, June 27, East Lansing, MI, USA.
2012 “Hormone-induced mitochondrial plasticity mediates steroid formation in steroidogenic cells” Mitochondria: Energy, Signals and Homeostasis ASBMB-sponsored Symposium, June 27-29, 2012, Michigan State University, East Lansing, MI, USA.
2012 "Challenges and opportunities in translational research in Academia and Pharmaceutical Industry” Pharmacology Career Day, McGill University, March 14, Montreal, Canada
2012 "Research in Academia and Pharmaceutical Industry; a changing environment” Drug Development Training Program Conference, McGill University, March 30, Montreal, Canada
2012 “Odyssey of the steroidogenic cholesterol: a story of protein trafficking, sex, and drugs” Department of Medicine, McGill University, Montreal, Quebec, Canada
2012 “The Research Institute of the MUHC Redevelopment Program” Council of Physicians, Dentists and Pharmacists, October 1, Montreal, Canada
2012 “De novo synthesis of steroids and oxysterols in adipocytes” 46th Annual Conference on Gene Families and Isozymes, December 4-9, St Lucia Island, Saint Lucia
2012 “Odyssey of the steroidogenic cholesterol: a story of protein trafficking, sex, and drugs” INSERM UMR 788, University Paris-Sud 11, Le Kremlin-Bicetre, December 17, Paris, France
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2013 “Odyssey of the steroidogenic cholesterol: a story of protein trafficking, sex, and drugs” Research Center, University of Montreal Hospital Center, January 23, Bromont, Quebec, Canada
2013 “Politics in the Research Environment” Hellenic Young Professionals’ Exchange, Montreal, Quebec, January 24, Canada
2013 “Steroids: hormones, drugs and diagnostics” Department of Pharmacology, McGill University, February 15, Montreal, Quebec, Canada
2013 “Phthalate-induced epigenetic regulation of adrenal function” International Congress on Steroid Research, March 10-13, Chicago, Illinois, USA
2013 “Fetal origin of endocrine dysfunction in the adult: the phthalate model” American Society of Andrology, April 13-16, San Antonio, Texas, USA
2013 “Translocator protein in human breast cancer” World Cancer Congress (WCC-2013), May 23-25, Xi’an, China, declined
2013 "Caprospinol: from a concept to a drug” Drug Development Training Program Conference, McGill University, May 31, Montreal, Canada
2013 “Shaping our future in the changing global biopharma R&D environment”, Quebec Centre for Drug Development, June 12, Montreal, Quebec, Canada
2013 “Regulation of the mitochondrial cholesterol import machinery in steroidogenic cells” Endocrine Society Annual meeting, June 15-19, San Francisco, California, USA
2013 “Prostate disease” endogenous steroid production, GnRH receptors and cell growth” Expert panel meeting on lower urinary tract symptoms and GnRH antagonists therapy in patients with prostate cancer. Ferring Pharmaceuticals. September 7, Copenhagen, Denmark
2013 “Comprendre et contrôler la formation des hormones stéroïdiennes: implications thérapeutiques” Club de recherches cliniques du Québec (CRCQ), September 26-28, Manoir du Lac-Delage, Québec, Canada
2013 “Function of the translocator protein TSPO in health and disease” 16th International Symposium on Molecular Medicine, October 10-12, Hersonissos, Crete, Greece
2013 «Structure and function of the steroidogenic metabolon” The Zavalkoff Family Foundation Symposium October 28, McGill University, Montreal, Canada
2013 “Blocking 14-3-3ε protein adapter and mitochondrial VDAC1 interactions induces luteinizing hormone-independent androgen formation in the male” 47th Annual Conference on Gene Families and Isozymes, December 1-7, Antigua
2014 “Fetal origin of endocrine dysfunction in the adult: the phthalate model” Centre Hospitalier Universitaire Sainte-Justine, January 27, Montreal, Canada
2014 “Challenges for sustaining highly competitive research at the MUHC, Montreal, Quebec and Canada” Academic Health Sciences Network Symposium, Delta Ottawa City Centre, March 12-13, Ottawa, Ontario, Canada
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2014 “Pharmacological regulation of steroid biosynthesis: from testis to brain” American Society of Andrology, April 4-8, Atlanta, Georgia, USA
2014 “Lessons from 30 years research on TSPO” INMiND Consortium; Symposium on Microglia Imaging and Biology, April 24-25, Manchester, UK
2014 “The Research Institute of the MUHC Redevelopment Program” University Joseph Fournier, April 30, Grenoble, France
2014 “The pharmacology of the mitochondrial cholesterol transport and steroidogenesis” Adrenal Cortex Conference, June 18-20, Chicago, IL, USA
2014 “Review of the impact of 5ARI on neurosteroid pathways” Colloquium on Research Avenues to Explore In Defining The Link Between 5-Alpha Reductase Inhibitors And Sexual Dysfunction, Sexual Medicine Society of North America, July 19, Washington, DC, USA
2014 “Imaging in Translational Medicine at the Research Institute of the MUHC” Translational Imaging in Alzheimer’s and Parkinsons’s Disease Symposium, September 22-23, Montreal, Quebec, Canada
2014 “Pharmacological regulation of steroidogenesis: new tools for the treatment of hypogonadism" International Andrology Symposium, November, Heraklion, Greece
2014 “University hospital centers’ role in the healthcare ecosystem: the Glen Campus example” Servier Canada, October 9, Laval, QC, Canada
2014 “Developmental origin of adult diseases” Quebec Epigenetics Symposium, November 10, St Justines University Hospital, Montreal, Quebec, Canada
2014 “Translocator protein in steroid and neurosteroid biosynthesis: from structure to pharmacology” Pfizer Neuroschiences, November 12, Cambridge, MA, USA
2014 “Concepts, patents, publications, commercialization: a personal choice” Réseau Québécois en Reproduction (RQR) Workshop on knowledge translation, December 1, Sherbrook University, Longueil, Quebec, Canada
2014 “Translocator protein in steroid and neurosteroid biosynthesis: from structure to pharmacology” Mitochondrial Stress Response Pathways: Functions and Applications of the 18kDa Protein TSPO. Biochemical Society, University of London, December 17-18, London, UK
2015 “Translocator protein in mitochondrial cholesterol transport and the pharmacology of steroidogenesis” Bioenergetics Symposium, Biophysical Society Annual Meeting, February 7th, Baltimore, MD, USA
2015 “Cholesterol trafficking for steroid biosynthesis in MA-10 mouse tumor Leydig cells”. The XXIII North American Testis Workshop, April 15-18, Salt Lake City, Utah, USA
2015 “Prenatal phthalate exposure: epigenetic changes leading to lifelong impact on steroid formation”. 8th Copenhagen Workshop on Endocrine Disrupters, Danish Environmental Protection Agency, April 27-30, Copenhagen, Denmark
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2015 “Prenatal phthalate exposure: epigenetic changes leading to lifelong impact on steroid formation”. Annual McGill Endocrinology Retreat, May 21st, Montreal, QC, Canada
2015 “The future and importance of drug development: du nouveau or du deja vu?” 1st Forum on drug development. Reseau Quebeqois de la Recherche sur le Medicament (RQRM), June 1st, Quebec city, QC, Canada
2015 “Steroid biosynthesis in prostate diseases” 25th Annual McGill Urology Research Day, International Symposium, September 16th, Montreal, QC, Canada
2015 “Regulation of steroidogenesis by hormones, drugs and the environment” Workshop on Male Reproductive Biology “Building bridges in Andrology Research”, November 9-12, Sao Paulo, SP, Brazil
2015 “Linking science to technological innovation: challenges and opportunities in male reproductive medicine”. Updates in Reproductive Biology” Conference, November 9-12, Sao Paulo, SP, Brazil
2015 “Prenatal phthalate exposure: epigenetic changes leading to lifelong impact on steroid formation”. Society for Basic Urologic Research Symposium, November 12-15, Fort Lauderdale, Florida, USA
2015 "Challenges and opportunities in translational research in Academia and Pharmaceutical Industry” Réseau Québécois en Reproduction (RQR) Workshop on knowledge translation, RQR meeting November 16, Montreal, Canada
2015 “An action plan for improving the clinical trials environment in Canada”, Clinical Research Panel, Making Canada Better Rx&D Conference, November 17, Hyatt Regency Hotel, Montreal, Canada
2015 “De novo steroid biosynthesis in human prostate cell lines and biopsies” 49th Annual GFI Conference, December 6-12, Roberts Grove Resort Placencia, Belize
2016 “The pharmacology of the mitochondrial cholesterol transport and steroidogenesis" Indian Science Congress, January 3-7, Mysore, India
2016 “Regulation of steroid biosynthesis by hormones, drugs and the environment” Center for Research on Reproduction and Women’s Health, University of Pennsylvania, March 2nd, Philadelphia, PA, USA
2016 “Regulation of steroid biosynthesis by hormones, drugs and the environment” Experimental therapeutics and metabolism program, Research Institute of the McGill University Health Centre, March 17 Monteeal, QC, Canada
2016 “TSPO mutations and polymorphisms impair the rate of steroid synthesis” 17th Adrenal cortex Conference, March 29-31, Boston, MA, USA
2016 “Regulation of Leydig cell function in the adult” International Symposium of Animal Biology of Reproduction, November 6-9, 2016, Sao Paolo, Brasil (declined)
2016 “Regulation of steroid biosynthesis by hormones, drugs and the environment” Laboratory of Microbiology Signals and Microenvironment, Normandie University & University of Rouen, April 19, Evreux, France
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2016 “The Odyssey of steroidogenic cholesterol: disturbances and therapies” Pleanry lecture, University of Rouen, April 21, Rouen, France
2016 “Prenatal phthalate exposure: epigenetic changes leading to lifelong impact on steroid formation” Division of Endocrinology Grand Rounds, McGill University, Montreal, Canada
2016 “Crispr/Cas9-mediated Tspo gene mutations leab to reduced steroid formation in MA-10 mouse Leyrdig tumor cells”. 50th Annual Gene Families and Isozymes (GFI) Conference, December 5-10, Rio Grande, Puerto Rico, USA
2016 “Regulation of steroidogenesis by hormones, drugs and the environment” Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, December 14, Los Anegeles, CA, USA
2017 “Translocator protein: an update on structure and function” Pleanry lecture; 9th International meeting in steroids and the nervous system. February10-14, Torino, Italy
268 invited presentations since 1987 (oral communications in meetings are not included)
Over 50 declined invitations to present at national and international meetings.
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E. Original peer-reviewed publications:
1. Papadopoulos V, Joly E, Simon MJ, Drosdowsky MA (1984). In vitro estradiol biosynthesis in immature rat testis. Pathologie & Biologie, 32:843-846.
2. Papadopoulos V, Carreau S, Drosdowsky MA (1985). Effects of phorbol ester and phospholipase C on LH-stimulated steroidogenesis in purified rat Leydig cells. FEBS Letters, 188:312-316.
3. Papadopoulos V, Drosdowsky MA, Carreau S (1986). In vitro effects of prolactin and dexamethazone on rat Leydig cell aromatase activity. Andrologia, 18:79-83.
4. Papadopoulos V, Carreau S, Szerman-Joly E, Drosdowsky MA, Dehennin L, Scholler R (1986). Rat testis 17-estradiol: identification by gas chromatography-mass spectrometry and age related cellular distribution. J Steroid Biochemistry, 24:1211-1216.
5. Papadopoulos V, Carreau S, Drosdowsky MA (1986). Effects of seminiferous tubules secreted factor(s) on Leydig cell cyclic AMP production in mature rat. FEBS Letters, 202:74-78.
6. Papadopoulos V, Kamtchouing P, Drosdowsky MA, Carreau S (1987). Spent media from immature seminiferous tubules and Sertoli cell inhibit adult rat Leydig cell aromatase activity. Hormone & Metabolic Research, 19:62-64.
7. Papadopoulos V, Kamtchouing P, Drosdowsky MA, Carreau S (1987). Effects of the transmethylation inhibitor S-Adenosyl Homocysteine and the methyl donor S-Adenosyl-Methionine on rat Leydig cell function in vitro. J Steroid Biochemistry, 26:93-98.
8. Papadopoulos V, Carreau S, Drosdowsky MA (1987). Effect of leukotriene B4 (LTB4) on purified rat Leydig cell function. Medical Research Science, 15:11-12.
9. Carreau S, Papadopoulos V, Drosdowsky MA (1987). The adult rat Leydig cell aromatase activity is stimulated by a Sertoli cell factor. Steroids, 50:617-618.
10. Benhaim A, Bonnamy PJ, Papadopoulos V, Mittre H, Leymarie P (1987). In vitro action of PGF2a on progesterone and cyclic AMP synthesis in small bovine luteal cells. Prostaglandins, 33:227-240.
11. Papadopoulos V, Kamtchouing P, Drosdowsky MA, Hochereau de Reviers MT, Carreau S (1987). Adult rat Sertoli cells secret factors, which modulate Leydig cell function. J Endocrinology, 74:459-467.
12. Carreau S, Papadopoulos V, Drosdowsky MA (1988). Paracrine regulation of rat Leydig cell aromatase activity: age related effects. Pathologie & Biologie, 36:1002-1006.
13. Carreau S, Papadopoulos V, Drosdowsky MA (1988). Induction of adult rat Leydig cell aromatase activity by a Sertoli cell factor. Endocrinology, 122:1103-1109.
14. Almahbobi G, Papadopoulos V, Carreau S, Silberzahn P (1988). Age-related morphological and functional changes in the Leydig cells of the horse. Biology of Reproduction, 38:653-665.
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15. Kamtchouing P, Pinon-Lataillade G, Papadopoulos V, Guillaumin JM, Bardos P, Maas J, Perreau C, Drosdowsky MA, Courot M, Hochereau de Reviers MT, Carreau S (1988). Effects of continuous low dose irradiation on the rat Sertoli cell function. Reproduction Nutrition & Development, 28:1009-1017.
16. Carreau S, Papadopoulos V , Boujrad N, Drosdowsky MA (1988). Effects of cisplatin and bleomycin on mature rat Leydig cell testosterone production. J Steroid Biochemistry, 29:423-425.
17. Foucault P, Menard S, Papadopoulos V, Bureau F, Travert G, Labat-Robert J, Meinon G, Siramy M, Drosdowsky MA (1988). Study of an optimal biological profile for demonstrating pancreatic involvement in acute abdominal syndrome. Annales Biologie Clinique, 46:441-448.
18. Kamtchouing P, Pinon-Lataillade G, Papadopoulos V, Drosdowsky MA, Hochereau de Reviers MT, Carreau S (1988). Changes in androgen binding protein (ABP) production following continuous low dose gamma irradiation of adult rats. Steroids, 52:349-350.
19. Papadopoulos V, Hall PF (1989). Isolation and characterisation of protein kinase C from Y-1 adrenal cell cytoskeleton. J Cell Biology, 208:553-567.
20. Papadopoulos V, Brown AS, Hall PF (1989). Isolation and characterization of calcineurin from adrenal cell cytoskeleton. Identification of substrates for Calcium-Calmodulin dependent phosphatase activity. Molecular & Cellular Endocrinology, 63:23-38.
21. Yanagibashi K, Papadopoulos, Masaki E, Iwaki T, Kawamura M, Hall PF (1989). Forskolin activates voltage-dependent calcium channels in bovine but not in rat fasciculata cells. Endocrinology, 124:2383-2391.
22. Iida S, Papadopoulos V, Hall PF (1989). The influence of exogenous free cholesterol on steroid synthesis in cultured adrenal cells. Endocrinology, 124:2619-2624.
23. Mukhin AG, Papadopoulos V, Costa E, Krueger KE (1989). Mitochondrial benzodiazepine receptors regulate steroid biosynthesis. Proceedings of the National Academy of Sciences USA, 86:9813-9816.
24. Boujrad N, Papadopoulos V, Drosdowsky MA, Carreau S (1989). Role of a purified Sertoli cell protein (CMB-21) in the biosynthesis of Leydig cell testosterone in the immature rat. Pathologie & Biologie, 37:819-824.
25. Boujrad N, Denis I, Papadopoulos V, C. Pisselet C, Bouchard P, Drosdowsky MA, Hochereaau de Reviers MT,. Carreau S (1990). Evidence for LH inhibitor(s) in sheep and human sera. Comptes Rendu d' Academie de Science, France, 310:417-421.
26. Papadopoulos V, Kamtchouing P, Boujrad N, Pisselet C, Perreau C, Locatelli A, Drosdowsky MA, Hochereau de Reviers MT, Carreau S (1990). Evidence for a LH inhibiting activity in ovine peripheral and testicular blood. Acta Endocrinologica, 123:345-352.
27. Papadopoulos V, Widmaier EP, Hall PF (1990). The role of calmodulin in the responses to adrenocorticotropin of plasma membranes from adrenal cells. Endocrinology, 126:2465-2473.
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28. Papadopoulos V, Brown AS, Hall PF (1990). Calcium-calmodulin-dependent phosphorylation of cytoskeletal proteins from adrenal cells. Molecular & Cellular Endocrinology, 74:109-124.
29. Ojeifo J, Byers SW, Papadopoulos V, Dym M (1990). Sertoli cell-secreted proteins stimulate DNA synthesis in highly purified rat Leydig cells. J Reproduction & Fertility, 90:93-108.
30. Davis CM, Papadopoulos V, Sommers CL, Kleinman HK, Dym M (1990). Differential expression of extracellular matrix components in rat Sertoli cells. Biology of Reproduction, 43:860-869.
31. Papadopoulos V, Mukhin AG, Costa E, Krueger KE (1990). The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. J Biological Chemistry, 265:3772-3779.
32. Krueger KE, Papadopoulos V (1990). Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from the outer to inner mitochondrial membranes in adrenocortical cells. J Biological Chemistry, 265:15015-15022.
33. Davis CM, Papadopoulos V, Jia M-C, Yamada Y, Kleinman HK, Dym M (1991). Identification and partial characterization of laminin binding proteins in immature rat Sertoli cells. Experimental Cell Research, 193:262-273.
34. Papadopoulos V, Berkowich A, Krueger KE (1991). Role of DBI and its processing products on the peripheral-type benzodiazepine receptors: stimulation of steroid biosynthesis. Neuropharmacology, 30:1417-1423.
35. Dym M, Lamsam-Casalotti S, Jia M-C, Kleinman HK, Papadopoulos V (1991). Basement membrane increases G-protein levels and FSH responsiveness of Sertoli cell adenylyl cyclase. Endocrinology, 128:1167-1176.
36. Papadopoulos V, Nowzari FB, Krueger KE (1991). Hormone-stimulated steroidogenesis is coupled to mitochondrial benzodiazepine receptors. J Biological Chemistry, 266:3682-3687.
37. Onoda M, Djakiew D, Papadopoulos V (1991). Pachytene spermatocytes regulate the secretion of Sertoli cell protein(s) which stimulates Leydig cell steroidogenesis. Molecular & Cellular Endocrinology, 77:207-216.
38. Kamtchouing P, Hochereau de Reviers MT, Perreau C, Papadopoulos V, Drosdowsky MA, Carreau S (1991). Age related changes in the function of the pituitary-gonadal axis in a sterile male rat mutant (hd/hd). Biology of Reproduction, 45:11-19.
39. Papadopoulos V (1991). Identification and purification of a human Sertoli cell secreted protein (hSCSP-80) stimulating Leydig cell steroid biosynthesis. J Clinical Endocrinology & Metabolism, 72:1332-1339.
40. Weeks BS, Papadopoulos V, Dym M, Kleinman HK (1991). cAMP promotes branching of laminin-induced neuronal processes. J Cellular Physiology, 147:62-67.
41. Papadopoulos V, Berkovich A, Krueger KE, Costa E, Guidotti A (1991). Diazepam Binding Inhibitor (DBI) and its processing products stimulate mitochondrial steroid
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biosynthesis via an interaction with mitochondrial benzodiazepine receptors. Endocrinology, 129:1481-1488.
42. Brown AS, Hall PF, Shoyab M, Papadopoulos V (1992). Endozepine/Diazepam Binding Inhibitor in adrenocortical and Leydig cell lines: Absence of hormonal regulation. Molecular & Cellular Endocrinology, 83:1-9.
43. Papadopoulos V, Guarneri P, Krueger KE, Guidotti A, Costa E (1992). Pregnenolone biosynthesis in C6 glioma cell mitochondria: regulation by a Diazepam Binding Inhibitor mitochondrial receptor. Proceedings of the National Academy of Sciences USA, 89:5113-5117.
44. Guarneri P, Papadopoulos V, Pan B, Costa E (1992). Regulation of pregnenolone synthesis in C6 glioma cells by 4'-chlorodiazepam. Proceedings of the National Academy of Sciences USA, 89:5118-5122.
45. Kozikowski AP, Ma D, Romeo E, Auta J, Papadopoulos V, Puia G, Costa E (1992) Synthesis of (2-Arylindol-3-yl) acetamides as probes of mitochondrial steroidogenesis - A new mechanism for GABAA receptor modulation. Angewandte Chemie, 31:1060-1062
46. Romeo E, Auta J, Kozikowsky AP, Ma D, Papadopoulos V, Puia G, Costa E, Guidotti A(1992). 2-Aryl-3-Indoleacetamides (FGIN-1): A new class of potent and specific ligands for the mitochondrial DBI receptor. J Pharmacology &Experimental Therapeutics, 262:971-978.
47. Oke BO, Suarez-Quian CA, Riond J, Ferrara P, Papadopoulos V (1992). Cell surface localization of the peripheral-type benzodiazepine receptor (PBR) in adrenal cortex. Molecular & Cellular Endocrinology, 87:R1-R6.
48. Radhakrishnan B, Oke BO, Papadopoulos V, DiAugustine R, Suarez-Quian CA (1992). Characterization of epidermal growth factor (EGF) in mouse testis. Endocrinology, 131:3091-3099.
49. Dym M, V. Papadopoulos (1992). Dual compartment (bicameral) culture: role of basement membrane in epithelial differentiation. Cell Biology & Toxicology, 8:55-59.
50. Garnier M, Boujrad N, Oke BO, Brown AS, J. Riond J, Ferrara P, Shoyab M, Suarez-Quian CA, Papadopoulos V (1993). Diazepam binding inhibitor (DBI) is a paracrine/autocrine regulator of Leydig cell proliferation and steroidogenesis. Action via peripheral-type benzodiazepine receptor (PBR) and independent mechanisms. Endocrinology, 132:444-458.
51. Papadopoulos V (1993). Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endocrine Reviews, 14:222-240.
52. Boujrad N, Hudson Jr JR, Papadopoulos V (1993). Inhibition of hormone-stimulated steroidogenesis in cultured Leydig tumor cells by a cholesterol-linked phosphorothioate oligodeoxynucleotide antisense to diazepam binding inhibitor. Proceedings of the National Academy of Sciences USA, 90:5728-5731
53. Lamsam-Casalotti S, Onoda M, Papadopoulos V, M. Dym M (1993) Developmental expression of GTP-binding proteins in rat testis. J Reproduction & Fertility, 99:487-495
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54. Papadopoulos V, Jia M-C, Culty M, Hall PF, Dym M (1993). Rat Sertoli cell aromatase cytochrome P450: regulation by cell culture conditions and relationship to the state of cell differentiation. In Vitro Cellular & Developmental Biology, 29A:943-949
55. Papadopoulos V, Guarneri P (1994). Regulation of C6 glioma cell steroidogenesis by adenosine 3',5'-cyclic monophosphate. Glia, 10:75-78.
56. Garnier M, Dimchev AB, Boujrad N, Price MJ, Musto NA, Papadopoulos V (1994). In vitro reconstitution of a functional peripheral-type benzodiazepine receptor. Molecular Pharmacology, 45:201-211.
57. Vacchio MS, Papadopoulos V, Ashwell JD (1994). Steroid production in the thymus: implications for thymocyte positive selection. J Experimental Medicine, 179:1835-1846.
58. Guarneri P, Guarneri R, Cascio C, Pavasant P, Piccoli F, Papadopoulos V (1994). Neurosteroidogenesis in rat retinas. J Neurochemistry, 63:86-96.
59. Whalin M, Boujrad N, Papadopoulos V, Krueger KE (1994). Studies on the phosphorylation of the 18 KDa mitochondrial benzodiazepine receptor protein. J Receptor Research, 14:217-228.
60. Ravindranath N, Papadopoulos V, Vornberg W, Zitzmann D, Dym M (1994). Ultrastructural distribution of calcium in the rat testis. Biology of Reproduction, 51:50-62.
61. Papadopoulos V, Dym M (1994). Sertoli cell spreading on basement membrane is mediated by the c-fos protooncogene. Proceedings of the National Academy of Sciences USA, 91:7027-7031.
62. Garnier M, Boujrad N, Ogwuegbu SO, Hudson Jr SR, Papadopoulos V (1994). The polypeptide diazepam binding inhibitor and a higher affinity peripheral-type benzodiazepine receptor sustain constitutive steroidogenesis in the R2C Leydig tumor cell line. J Biological Chemistry, 269:22105-22112.
63. Papadopoulos V, Boujrad N, Ikonomovic M, Ferrara P, Vidic B (1994). Topography of the Leydig cell mitochondrial peripheral-type benzodiazepine receptor. Molecular & Cellular Endocrinology, 104:R5-R9.
64. Boujrad N, Gaillard J-L, Garnier M, Papadopoulos V (1994). Acute action of choriogonadotropin in Leydig tumor cells. Induction of a higher affinity benzodiazepine receptor related to steroid biosynthesis. Endocrinology, 135:1576-1583.
65. Guarneri P, Guarneri R, Cascio C, Piccoli F, Papadopoulos V (1995). GABA type A/benzodiazepine receptors regulate rat retina neurosteroidogenesis. Brain Research, 683:65-72.
66. Boujrad N, Ogwuegbu SO, Garnier M, Lee C-H, Martin BM, Papadopoulos V (1995). Identification of a stimulator of steroid hormone synthesis isolated from testis. Science, 268:1609-1612.
67. Dirami G, Papadopoulos V, Kleinman HK, Defreese DC, Musto NA, Dym M (1995) Identification of transferrin and inhibin-like proteins in Matrigel. In Vitro Cellular & Developmental Biology, 31:409-411.
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68. Vidic B, Boujrad N, Papadopoulos V (1995) Hormone-induced changes in the topography of the mitochondrial peripheral-type benzodiazepine receptor. Scanning, 17:V34-35
69. Papadopoulos V, Brown AS (1995) The peripheral-type benzodiazepine receptor, diazepam binding inhibitor, and steroidogenesis. J Steroid Biochemistry & Molecular Biology, 53:103-110.
70. Ravidranath N, Papadopoulos V, Brooker G, Dym M (1996) Sertoli cell calcium response to basement membrane and follicle stimulating hormone. Biology of Reproduction, 54:130-137.
71. Jia MC, Ravidranath N, Papadopoulos V, Dym M (1996) Regulation of c-fos mRNA in Sertoli cells by cAMP, calcium, and protein kinase C mediated pathways. Molecular & Cellular Biochemistry 156:43-49.
72. Amri H, Ogwuegbu SO, Boujrad N, Drieu K, Papadopoulos V (1996) In vivo regulation of the peripheral-type benzodiazepine receptor and glucocorticoid synthesis by the Ginkgo biloba extract EGb 761 and isolated ginkgolides. Endocrinology, 137:5707-5718.
73. Boujrad N, Vidic B, Papadopoulos V (1996). Acute action of choriogonadotropin on Leydig tumor cells. Changes in the topography of the mitochondrial peripheral-type benzodiazepine receptor. Endocrinology, 137:5727-5730.
74. Li H, Papadopoulos V, Vidic B, Dym M, Culty M (1997) Regulation of rat testis gonocyte proliferation by platelet-derived growth factor and estradiol: identification of signaling mechanisms involved. Endocrinology, 138:1289-1298
75. Vidic B, Boujrad N, Papadopoulos V (1997) Acute action of choriogonadotropin on Leydig tumor cells: Qualitative and quantitative transformation of lipid moieties. Anatomical Records, 248:374-379.
76. Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H, Vidic B, Brown AS, Reversat JL, Bernassau JM, Drieu K (1997) Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids, 62:21-28.
77. Moslemi S, Vibet A, Papadopoulos V, Camin L, Silberzahn P, Gaillard J-L (1997) Purification and characterization of equine testicular cytochrome P-450 aromatase. Comparison with the human enzyme. Comparative Biochemistry & Physiology, 118:217-227.
78. Kozikowski AP, Kotoula M, Ma D, Boujrad N, Tückmantel W, Papadopoulos V (1997) Synthesis and Biology of a 7-Nitro-2,1,3-benzoxadiazol-4-yl (NBD) Derivative of 2-Phenylindole-3-Acetamide: a Fluorescent Probe for the Peripheral-type Benzodiazepine Receptor. J Medicinal Chemistry, 40:2435-2439.
79. Amri H, Drieu K, Papadopoulos V (1997) Ex vivo regulation of adrenal cortical cell steroid and protein synthesis, in response to adrenocorticotropic hormone stimulation, by the Ginkgo biloba extract EGb 761 and isolated ginkgolides. Endocrinology, 138:5415-5426.
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80. Papadopoulos V, Amri H, Boujrad N, Li H, Vidic B, Garnier M (1997) Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line. J Biological Chemistry, 272:32129-32135.
81. Papadopoulos V (1998). Structure and function of the peripheral-type benzodiazepine receptor in steroidogenic cells. Proceedings of the Society for Experimental Biology & Medicine 217:130-142.
82. Cascio C, Prasad VVK, Lin YY, Lieberman S, Papadopoulos V (1998) Detection of P450c17-independent pathways for dehydroepiandrosterone (DHEA) biosynthesis in brain glial tumor cells. Proceedings of the National Academy of Sciences USA, 95:2862-2867.
83. Li H, Papadopoulos V (1998) Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology, 139:4991-4997.
84. Papadopoulos V, Widmaier EP, Amri H, Zilz A, Li H, Culty M, Castello R, Philip GH, Sridaran R, Drieu K (1998) In vivo studies on the role of the peripheral benzodiazepine receptor in steroidogenesis. Endocrine Research, 24:479-487.
85. Sridaran R, Philip GH, Li H, Culty M, Liu Z, Stocco DM, Papadopoulos V (1999) GnRH agonist treatment decreases progesterone synthesis, luteal peripheral benzodiazepine receptor mRNA, ligand binding, and steroidogenic acute regulatory protein expression during pregnancy. J Molecular Endocrinology, 22:45-54.
86. Zilz A, Li H, Castello R, Papadopoulos V, Widmaier EP (1999) Developmental expression of the peripheral-type benzodiazepine receptor and the advent of steroidogenesis in rat adrenal glands. Endocrinology, 140:859-864.
87. Hardwick M, Fertikh D, Culty M, Li H, Vidic B, Papadopoulos V (1999) Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol. Cancer Research, 59:831-842.
88. Culty M, Li H, Boujrad N, Bernassau JM, Reversat JL, Amri H, Vidic B, Papadopoulos V (1999) In vitro studies on the role of the peripheral benzodiazepine receptor in steroidogenesis. J Steroid Biochemistry & Molecular Biology, 69:123-130.
89. Papadopoulos V, Dharmarajan AM, Li H, Culty M, Lemay M, Sridaran R (1999) Mitochondrial peripheral-type benzodiazepine receptor expression: correlation with the GnRH-agonist induced apoptosis in the corpus luteum. Biochemical Pharmacology, 58:1389-1393.
90. Amri H, Li H, Culty M, Teper G, Papadopoulos V (1999) Peripheral benzodiazepine receptor and adrenal steroidogenesis. Current Opinion in Endocrinology and Diabetes, 6:179-184.
91. Yao Z, Drieu K, Szweda LI, Papadopoulos V (1999) Free-radicals and lipid peroxidation do not mediate -amyloid-induced neuronal cell death. Brain Research, 847:203-210.
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92. Brown RC, Cascio C, Papadopoulos V (2000) Pathways of neurosteroids biosynthesis in human brain: regulation of dehydroepiandrosterone formation by -amyloid. J Neurochemistry, 74:847-859.
93. Brown RC, Degenhardt B, Kotoula M, Papadopoulos V (2000) Location-dependent role of the peripheral-type benzodiazepine receptor in proliferation and steroid biosynthesis in human glioma cells. Cancer Letters, 156:125-132.
94. Boujrad N, Vidic B, Gazouli M, Culty M, Papadopoulos V (2000) The peroxisome proliferator perfluorodecanoic acid inhibits the peripheral-type benzodiazepine Receptor (PBR) expression and hormone-stimulated mitochondrial cholesterol transport and steroid formation in Leydig cells. Endocrinology, 141:3137-3148.
95. Papadopoulos V, Kapsis A, Li H, Amri A, Hardwick M, Culty M, Kasprzyk PG, Carlson M, Moreau J-P, Drieu K (2000) Drug-induced inhibition of the peripheral-type benzodiazepine receptor expression and cell proliferation in human breast cancer cells. AntiCancer Research, 20:2835-2848.
96. Cascio C, Brown RC, Liu Y, Han Z, Hales DB, Papadopoulos V (2000) Pathways of dehydroepiandrosterone formation in developing rat brain glia. J. Steroid Biochemistry & Molecular Biology, 75:177-186.
97. Yao Z, Drieu K, Papadopoulos V (2001) The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from -amyloid-induced cell death by inhibiting the formation of -amyloid-derived diffusible neurotoxic ligands. Brain Research, 889:181-190.
98. Li H, Yao Z, Degenhardt B, Teper G, Papadopoulos V (2001) Cholesterol binding at the cholesterol recognition/interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide. Proceedings of the National Academy of Sciences USA, 98:1267-1272.
99. Dees, JD, Gazouli M, Papadopoulos V (2001) Effect of mono-ethylhexyl phthalate on MA-10 Leydig tumor cell structure and function. Reproductive Toxicology, 15:171-187.
100. Culty M, Nakazato A, Gazouli M, Li H, Muramatsu M, Okuyama S, Papadopoulos V (2001) Peripheral benzodiazepine receptor binding properties and effects on steroid synthesis of two new phenoxyphenyl-acetamide derivatives, DAA1097 and DAA1106. Drug Development Research, 52:475-484.
101 Lacapère JJ, Delavoie F, Li H, Péranzi G, Maccario J, Papadopoulos V, Vidic B (2001) Structural and functional study of reconstituted peripheral benzodiazepine receptor (PBR). Biochem. Biophys. Res. Communic., 284:536-641.
102. Hardwick M, Rone J, Han J, Haddad B, Papadopoulos V (2001) Peripheral-type benzodiazepine receptor levels correlate with the ability of human breast cancer MDA-MB-231 cell line ability to grow in SCID mice. International Journal of Cancer, 94:322-327.
103. Li H, Degenhardt, Tobin D, Yao, Z., Tasken K, Papadopoulos V (2001) Identification, localization, and function in steroidogenesis of PAP7: A peripheral-type benzodiazepine receptor- and protein kinase A (RI)-associated protein. Molecular Endocrinology, 15:2211-2228.
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104. Miclo L, Perrin E, Driou A, Papadopoulos V, Boujrad N, Vanderesse R, Boudier J-F, Desor D, Inden G, Gaillard J-L (2001) Characterization of casozepine, a tryptic peptide from bovine s1-casein with benzodiazepine-like activity. FASEB Journal, 15:1780-1782.
105. Culty M, Luo L, Yao Z, Chen H Papadopoulos V, Zirkin B (2002) Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells. Journal of Andrology, 23:439-447.
106. Klouz A, Sapena R, Liu J, Maurice T, Tillement J-P, Papadopoulos V, Morin D (2002) Evidence for sigma-1-like receptors in isolated rat liver mitochondrial membranes. British Journal of Pharmacology, 135:1607-1615.
107. Gazouli M, Yao Z-X, Boujrad N, Corton C, Culty M, Papadopoulos V (2002) Effect of peroxisome proliferators on Leydig cell peripheral-type benzodiazepine receptor gene expression, hormone-stimulated cholesterol transport, and steroidogenesis: Role of the peroxisome proliferator-activator receptor . Endocrinology, 143:2571-2583.
108. Faure JP, Hauet T, Han Z, Goujon JM, Petit I, Mauco G, Eugene M, Carretier M, Papadopoulos V (2002) Polyethyleneglycol reduces early and long-term cold ischemia reperfusion and renal medulla injury. J Pharmacology & Experimental Therapeutics, 302:861-870.
109. Hardwick M, Rone J, Barlow K, Haddad B, Papadopoulos V (2002) Peripheral-type benzodiazepine receptor (PBR) gene amplification in MDA-231 aggressive breast cancer cells. Cancer Genetics & Cytogenetics, 139:48-51.
110. Yao Z, Papadopoulos V (2002) Function of ß-amyloid in cholesterol homeostasis: a lead to neurotoxicity. FASEB Journal, 16:1677-1679. Full text on line http://www.faseb.org/cgi/doi/10.1096/fj.02-0285fje.
111. Gazouli M, Han Z, Papadopoulos V (2002) Identification of a peptide antagonist to the peripheral-type benzodiazepine receptor (PBR) that inhibits hormone-stimulated Leydig cell steroid formation. J Pharmacology & Experimental Therapeutics, 303:627-632.
112. Morin D, Papadopoulos V, Tillement J-P (2002) Prevention of cell damage in ischemia: novel molecular targets in mitochondria. Expert Opinion in Therapeutic Targets, 6:315-334.
113. Amri H, Drieu K, Papadopoulos V (2002) Use of ginkgolide B and a ginkgolide-activated response element to control gene transcription: the example of the adrenocortical peripheral-type benzodiazepine receptor. Cellular and Molecular Biology, 48:633-639.
114. Li W, Pretner E, Shen L, Drieu K, Papadopoulos V (2002) Common gene targets of Ginkgo biloba extract (EGb) 761 in human tumor cells: Relation to cell growth. Cellular and Molecular Biology, 48:655-662.
115. Yao Z, Brown RC, Teper G, Greeson J, Papadopoulos V. (2002) 22R-hydroxycholesterol protects neuronal cells from ß-amyloid-induced cytotoxicity by binding to ß-amyloid peptide. Journal of Neurochemistry, 83:1110-1119.
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116. Hauet T, Han Z, Wang Y, Jayle C, Hameury F, Gibelin H, Goujon JM, Eugene M, Papadopoulos V (2002) Modulation of peripheral-type benzodiazepine receptor expression levels in ischemia reperfusion injury in a pig kidney graft model. Transplantation, 74:1507-1515.
117. Brown RC, Han Z, Cascio C, Papadopoulos V (2003) Oxidative stress mediated dehydroepiandrosterone formation in Alzheimer’s disease pathology. Neurobiology of Aging, 24:57-65.
118. Amri H, Drieu K, Papadopoulos V (2003) Transcriptional suppression of the adrenal cortical peripheral-type benzodiazepine receptor gene and inhibition of steroid synthesis by ginkgolide B. Biochemical Pharmacology, 65:717-729.
119. DeFeudis FV, Papadopoulos V, Drieu K (2003) Ginkgo biloba extracts and cancer: a research area in its infancy. Fundamental & Clinical Pharmacology, 17:405-417.
120. Liu J, Han Z, Sandrini F, Bei T, Matyakhina L, Stratakis CA, Papadopoulos V (2003) Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor- and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7 and studies in PRKAR1A mutant cells and tissues. FASEB Journal, 17:1189-1191. Full text of this article, go to http://www.fasebj.org/cgi/doi/10.1096/fj.02-1066fje.
121. Liu J, Cavalli LR, Haddad BR, Papadopoulos V (2003) Molecular cloning, genomic organization, chromosomal mapping and subcellular localization of mouse PAP7: a PBR and PKA-RI associated protein. Gene, 308:1-10.
122. Delavoie F, Li H, Hardwick M, Robert J-C, Giatzakis C, Péranzi G, Yao Z-X, Maccario J, Lacapère JJ, Papadopoulos V. (2003) In vivo and in vitro peripheral-type benzodiazepine receptor polymerization: functional significance in drug ligand and cholesterol binding. Biochemistry, 42:4506-4519.
123. Hauet T, Han Z, Doucet C, Ramella-Virieux S, Hadj Aissa A, Carretier M, Papadopoulos V (2003) A modified University of Wisconsin preservation solution with high-NA+ low-K+ content reduces reperfusion injury of the pig kidney graft. Transplantation 76:18-27.
124. Li W, Trovero F, Cordier J, Wang Y, Drieu K, Papadopoulos V (2003) Prenatal exposure of rats to Ginkgo biloba extract (EGb 761) increases neuronal survival/growth and alters gene expression in the developing fetal hippocampus. Developmental Brain Research, 144:169-180.
125. Lacapere JJ, Papadopoulos V (2003) Peripheral-type benzodiazepine receptor: Structure and function of a cholesterol binding protein in steroid and bile acid biosynthesis. Steroids, 68:569-585.
126. Han Z, Slack SR, Li W, Papadopoulos V (2003) Expression of peripheral benzodiazepine receptor (PBR) in human tumors: relationship to breast, colon and prostate tumor progression. Journal of Receptor Research and Signal Transduction, 23:225-238.
127. Faure JP, Baumert H, Han Z, Goujon JM, Favreau F, Dutheil D, Petit I, Barriere M, Tallineau C, Tillement JP, Carretier M, Mauco G, Papadopoulos V, Hauet T (2003) Evidence for a protective role of Trimetazidine during cold ischemia: targeting inflammation and nephron mass. Biochemical Pharmacology, 66:2241-2250.
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128. Xu, J, Lecanu L, Han Z, Yao Z, Greeson J, Papadopoulos V (2003) Inhibition of adrenal cortical steroid formation by procaine is mediated by reduction of the cAMP-induced 3-hydroxy-3-methylglutaryl-coenzyme A reductase messenger ribonucleic acid. J Pharmacology & Experimental Therapeutics, 307:1148-1157.
129. Wendler G, Lindemann P, Lacapere JJ, Papadopoulos V (2003) Protoporphyrin IX binding and transport by recombinant mouse peripheral-type benzodiazepine receptor. Biochem Biophys Res Comm, 311:847-852.
130. Diallo S, Lecanu L, Greeson J, Papadopoulos V (2004) A capillary gas chromatography/mass spectrometric method for the quantification of hydroxysteroids in human plasma. Analytical Biochemistry, 324:123-130.
131. Lecanu L, Yao W, Teper GL, Yao ZX, Greeson J, Papadopoulos V (2004) Identification of naturally occurring 22R-hydroxycholesterol derivatives preventing -amyloid-induced neurotoxicity, Steroids, 69:1-16.
132. Giatzakis C, Papadopoulos V (2004) Differential utilization of the promoter of peripheral-type benzodiazepine receptor by steroidogenic versus non-steroidogenic cell lines and the role of Sp1 and Sp3 in the regulation of basal activity. Endocrinology, 145:1113-1123.
133. Amri H, Li W, Drieu K, Papadopoulos V (2004) Identification of the ACTH and ginkgolide B-regulated 90-kDa protein (p90) in adrenocortical cells as a serotransferrin precursor protein homologue (Adrenotransferrin). Endocrinology, 145:1802-1809.
134. Baumert H, Faure JP, Zhang K, Petit I, Goujon JM, Dutheil D, Favreau F, Barriere M, Tillement JP, Mauco G, Papadopoulos V, Hauet T (2004) Evidence for a mitochondrial impact of trimetazidine during cold ischemia and reperfusion. Pharmacology 71:25-37.
135. Ostuni MA, Marazova K, Peranzi G, Vidic B, Papadopoulos V, Ducroc R, Lacapere JJ (2004) Functional characterization and expression of peripheral-type benzodiazepine receptor (PBR) in rat gastric mucosa: stimulation of chloride secretion by PBR ligands. American Journal of Physiology, 286:G1069-G1080.
136. Lee JJ, Eisenberg P, Papadopoulos V, Wang J, Widmaier EP (2004) Reversible changes in ACTH-induced adrenocortical steroidogenesis and expression of the peripheral-type benzodiazepine receptor during the ACTH-insensitive period in young rats. Endocrinology, 145:2165-2173.
137. Kletsas D, Li W, Han Z, Papadopoulos V (2004) Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation: Role of ERK, c-jun and ligand-activated PBR-independent pathways. Biochemical Pharmacology, 67:1927-1932.
138. Lindemann P, Koch A, Degenhardt B, Hause G, Grimm B, Papadopoulos V (2004) A novel Arabidopsis thaliana protein is a functional peripheral-type benzodiazepine receptor. Plant Cell Physiology, 45:723-733.
139. Yao Z-X, Han Z, Drieu K, Papadopoulos V (2004) Ginkgo biloba extract (EGb 761) inhibits β-amyloid production by lowering free cholesterol levels. Journal of Nutritional Biochemistry, 15:745-752.
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140. Li W, Amri H, Huang H, Wu C, Papadopoulos V (2004) Gene and protein profiling of the response of MA-10 Leydig tumor cells to human chorionic gonadotropin. Journal of Andrology, 25:900-913.
141. Hauet T, Yao Z, Bose, S, Wall CT, Han Z, Hales, BD, Miller WL, Culty M, Papadopoulos V (2005) Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into Leydig cell mitochondria. Molecular Endocrinology, 19:540-554.
142. Jamin N, Neumann J-M, Ostuni MA, Ngoc Vu TK, Yao Z-X, Murail S, Robert J-C, Giatzakis C, Papadopoulos V, Lacapère J-J (2005) Characterization of the cholesterol recognition amino acid consensus sequence of the peripheral-type benzodiazepine receptor. Molecular Endocrinology, 19:588-594.
143. Lecanu L, Yao W, Xu J, Greeson J, Papadopoulos V (2005) The local anesthetic procaine protects rat pheochromocytoma PC12 cells against -amyloid-induced neurotoxicity. Pharmacology, 74:65-78.
144. Lecanu L, Yao W, Piechot A, Greeson J, Tzalis D, Papadopoulos V (2005) Identification, design, synthesis, and pharmacological activity of (4-ethyl-piperaz-1-yl)-phenylmethanone derivatives with neuroprotective properties against β-amyloid-induced toxicity. Neuropharmacology, 49:86-96.
145. Liu Y, Yao ZX, Papadopoulos V (2005) Cytochrome P450 17α hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase activity associated with CYP17 in Leydig cells. Molecular Endocrinology, 19:1918-1931.
146. Liu Y, Yao Z, Bendavid C, Borgmeyer C, Han Z, Cavalli LR, Chan W-Y, Folmer J, Zirkin BR, Haddad BR, Gallicano GI, Papadopoulos V (2005) Haploinsufficiency of cytochrome P450 17α-hydroxylase/17,20 lyase (CYP17) causes infertility in male mice. Molecular Endocrinology, 19:2380-2389.
147. Teper G, Lecanu L, Greeson J, Papadopoulos V (2005) Multi-site ligand/protein docking identification methodology developed for optimizing spirostenol inhibition of -amyloid-induced neurotoxicity. Chemistry and Biodiversity, 2:1571-1579.
148. Lecanu L, Greeson J, Papadopoulos V (2006) Beta-amyloid and oxidative stress jointly induce neuronal death, amyloid deposits, gliosis, and memory impairment in the rat brain. Pharmacology, 76:19-33.
149. Papadopoulos V, Lecanu L, Brown, RC, Han Z, Yao ZX (2006) Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders. Neuroscience, 138:749-756.
150. Pretner E, Amri H, Li W, Brown R, Lin C-H, Makariou E, DeFeudis FV, Drieu K, Papadopoulos V (2006) Cancer-related overexpression of the peripheral-type benzodiazepine receptor and cytostatic anticancer effects of Ginkgo biloba extract (EGb 761). Anticancer Research, 26:9-22.
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151. Bastianetto S, Yao Z-X, Papadopoulos V, Quirion R (2006) Neuroprotective effects of green and black teas and their catechin galate esters against -amyloid-induced toxicity. European Journal of Neurosciences, 23:55-64.
152. Ge RS, Dong Q, Sottas CM, Papadopoulos V, Zirkin BR, Hardy MP (2006) In search of rat stem Leydig cells: identification, isolation and lineage specific development. Proceedings of the National Academy of Sciences USA, 103:2719-2724.
153. Lazzarini R, Maiorka PC, Liu J, Papadopoulos V, Palermo-Neto J (2006) Diazepam effects on carrageenan-induced inflammatory paw edema in rats: role of nitric oxide. Life Sciences, 78:3027-3034.
154. Papadopoulos V, Baraldi M, Guilarte TR, Knudsen TB, Lacapère JJ, Lindemann P, Norenberg, MD, Nutt D, Weizman, A, Zhang MR, Gavish M (2006) Translocator Protein (18 kDa): New nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends in Pharmacological Sciences, 27:402-409.
155. Tillement L, Lecanu L, Yao W, Greeson J, Papadopoulos V (2006) The spirostenol (22R,25R)-20α-spirost-5-en-3β-yl hexanoate blocks mitochondrial uptake of A in neuronal cells and prevents A-toxicity. Steroids, 71:725-731.
156. Cheah JH, Kim SF, Hester LD, Clancy KW, Patterson III SE, Papadopoulos V, Snyder SH (2006) Glutamate-NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via GTPase Dextras1. Neuron, 51:431-440.
157. Zhang K, Demeure O, Belliard A, Goujon J-M, Favreau F, Desurmont T, Mauco G, Barrière M, Carretier M, Milan D, Papadopoulos V, Hauet T (2006) Cloning, sequencing and chromosomal localization of pig peripheral benzodiazepine receptor: 3 different forms produced by alternative splicing. Mammalian Genome, 17:1050-1062.
158. Zhang K, Desurmont T, Goujon J-M, Favreau F, Cau J, Deretz S, Mauco G, Carretier M, Papadopoulos V, Hauet T (2006) Modulation of peripheral-type benzodiazepine receptor expression during ischemia reperfusion injury in a pig kidney model: a new partner of leukaemia inhibitory factor in tubular regeneration. J American College of Surgeons, 203:353-364.
159. Akula N, Lecanu L, Greeson J, Papadopoulos V (2006) 3D QSAR studies of AChE inhibitors based on molecular docking scoring functions and CoMFA. Bioorganic & Medicinal Chemistry Letters, 16:6277-6280.
160. Liu J, Rone, MB, Papadopoulos V (2006) Protein-protein interactions mediate cholesterol transport into mitochondria and steroid biosynthesis. Journal of Biological Chemistry, 281:38879-38893.
161. Xu J, Lecanu L, Tan M, Yao W, Greeson J, Papadopoulos V (2006) The benzamide derivative N-[1-(7-tert-Butyl-1H-indol-3-ylmethyl)-2-(4-cyclopropanecarbonyl-3-methyl-piperazin-1-yl)-2-oxo-ethyl]-4-nitro-benzamide (SP-10) reduces HIV-1 infectivity in vitro by modifying actin dynamics. Antiviral Chemistry and Chemotherapy, 17:331-342.
162. Li W, Hardwick M, Rosenthal DR, Culty M, Papadopoulos V (2007) Peripheral-type benzodiazepine receptor overexpression and knockdown in human breast cancer cells
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indicate its prominent role in tumor cell proliferation. Biochemical Pharmacology,73:491-503.
163. Azarashvili T, Yurkov I, Krestinina O, Grachev D, Evtodienko Y, Papadopoulos V, Reiser G (2007) Involvement of peripheral Benzodiazepine receptor in permeability transition pore opening in rat brain mitochondria. Cell Calcium, 42:27-39.
164. Liu Y, Dettin L, Folmer J, Zirkin BR, Papadopoulos V (2007) Abnormal morphology of spermatozoa in cytochrome P450 17-hydroxylase/17,20-lyase (CYP17) deficient mice. Journal of Andrology, 28:453-460.
165. Veenman L, Papadopoulos V, Gavish M (2007) Channel functions of the 18 kDa translocator protein (TSPO): Regulation of apoptosis and steroidogenesis as part of the host defense response. Current Pharmaceutical Design, 13:2385-2405.
166. Papadopoulos V, Liu J, Culty M (2007) Is there a mitochondrial signaling complex facilitating cholesterol import? Molecular Cellular Endocrinology, 265-266: 59-64.
167. Levine SL, Han Z, Liu J, Farmer DR, Papadopoulos V (2007) Surfactant-induced disruption of mitochondrial function inhibits MA-10 Leydig cell steroidogenesis. Cell Biology and Toxicology, 23:385-400.
168. Giatzakis C, Batarseh A, Dettin L, Papadopoulos V (2007) The role of Ets transcription factors in the basal transcription of the Translocator protein (18kDa). Biochemistry, 46:4763-4774.
169. Bai M, Wyatt SK, Han Z, Papadopoulos V, Bornhop DJ. (2007) A novel conjugable translocator protein ligand labeled with a fluorescence dye for in vitro imaging. Bioconjug Chem, 18:1118-1122.
170. Yao ZX, Han Z, Xu, J, Greeson J, Papadopoulos V (2007) 22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. Neuroscience, 148:441-453.
171. Lecanu L, Papadopoulos V (2007) Cutting-edge patents in Alzheimer’s disease drug discovery: Anticipation of potential future treatments. Recent Patents on CNS Drug Discovery, 2:113-123.
172. Ostuni MA, Ducroc R, Péranzi G, Tonon M-C, Papadopoulos V, and Lacapere J-J (2007) Translocator protein (18 kDa) ligand PK 11195 induces transient mitochondrial Ca2+ release in HT-29 human colon cancer cells. Biology of the Cell, 99:639-647.
173. Doucet C, Zhang K, Desurmont T, Hebrard W, Scepi M, Nadeau C, Cau J, Leyre P, Febrer G, Carretier M, Richer JP, Papadopoulos V, Hauet T, Burucoa C, Goujon JM (2007) Influence of warm ischemia time on peripheral-type benzodiazepine receptor: a new aspect of the role of mitochondria. Nephron Exp Nephrol 107:e1-11.
174. Bai M, Rone MB, Papadopoulos V, Bornhop DJ (2007) A novel functional translocator protein ligand for cancer imaging. Bioconjug Chem, 18:2018-2023.
175. Rosenberg BG, Chen H, Folmer J, Liu J, Papadopoulos V, Zirkin BR (2008) Gestational exposure to atrazine: effects on the postnatal development of male offspring. Journal of Andrology, 29:304-311.
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176. Ostuni MA, Tumilasci OR, Péranzi G, Cardoso EML, Contreras LN, Arregger AL, Papadopoulos V, Lacapere J-J (2008) Effect of Translocator protein (18 kDa) ligand binding on neurotransmitter-induced salivary secretion in rat submandibular glands. Biology of the Cell, 100:427-439.
177. Culty M, Thuillier R, Li W, Wang Y, Martinez-Arguelles DB, Benjamin CG, Triantafillou KM , Zirkin BR, Papadopoulos V (2008) In utero exposure to di-(2-ethylhexyl) phthalate exerts both short-term and long-lasting suppressive effects on testosterone production. Biology of Reproduction, 78:1018-1028.
178. Murail S, Robert JC, Coïc YM, Neumann JM, Ostuni MA, Yao, ZX, Papadopoulos V, Jamin N, Lacapère J-J (2008) Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand binding. Biochimica Biophysica Acta, 1778:1375-1381.
179. Doucet C, Milin S, Favreau F, Desurmont T, Manguy E, Hebrard W, Yamamoto Y, Mauco G, Eugene M, Papadopoulos V, Hauet T, Goujon JM. (2008) A p38 mitogen-activated protein kinase inhibitor protects against renal damage in a non-heart beating donor model. Am J Physiol Renal Physiol, 295:F179-191.
180. Patchev VK, Bachurin SO, Fritzemeier K-H, Albers M, Papadopoulos V (2008) Neurotropic estrogens: Essential profile and endpoints for drug discovery. Drug Discovery Today, 13:734-747.
181. Batarseh A, Giatzakis C, Papadopoulos V (2008) Phorbol-12-myristate 13-acetate acting through protein kinase Cε induces translocator protein (18-kDa) Tspo gene expression. Biochemistry, 47:12886-12899.
182. Midzak AS, Chen H, Papadopoulos V, Zirkin BR (2009) Leydig cell aging and the mechanisms of reduced testosterone synthesis. Molecular Cellular Endocrinology, 299:23-31.
183. Lecanu L, Tillement L, Rammouz G, Tillement JP, Lang T, Greeson J, Papadopoulos V (2009) Caprospinol: moving from a neuroactive steroid to a neurotropic drug. Expert Opinion in Investigational Drugs, 18:265-276.
184. Rone, M, Fan J, Papadopoulos V (2009) Cholesterol transport in steroid biosynthesis: Role of protein-protein interactions and implications in disease states. Biochimica Biophysica Acta (Molecular & Cell Biology of Lipids), 1791:646-658.
185. Liu Y, Procivavsek A, Papadopoulos V (2009) Dehydroepiandrosterone formation is independent of cytochrome P450 17α-hydroxylase/17,20 lyase activity in the mouse brain. J Steroid Biochemistry & Molecular Biology, 115:86-90.
186. Papadopoulos V, Lecanu L (2009) Translocator protein (18 kDa) TSPO: an emerging therapeutic target in neurotrauma. Experimental Neurology, 219:53-57.
187. Ostuni MA, Péranzi G, Ducroc R, Vidic B, Dumont J, Papadopoulos V, Lacapere J-J (2009) Distribution, pharmacological characterization and function of the 18-kDa translocator protein in rat small intestine. Biology of the Cell, 101:573-586.
188. Favreau F, Rossard L, Zhang K, Desurmont T, Manguy E, Belliard A, Fabre S, Liu J, Han Z, Thuillier R, Papadopoulos V, Hauet T (2009) Expression and modulation of
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Translocator Protein and its partners by hypoxia re-oygenation or ischemia and reperfusion in porcine renal models. American Journal of Physiology - Renal Physiology, 297:F177-190.
189. Chapalain A, Chevalier S, Orange N, Papadopoulos V, Feuilloley MGJ (2009) Bacterial orthologs of mammalian translocator protein with virulence regulating activity. PLOS One, 4(6):e6096.
190. Rone MB, Young JC, Liu J, Blonder J, Veenstra T, Papadopoulos V (2009) Targeting and insertion of the cholesterol-binding Translocator Protein (18-kDa) into the outer mitochondrial membrane. Biochemistry, 48:6909-6920.
191. Xu J, Lecanu L, Tan M, Greeson J, Papadopoulos V (2009) Identification of a benzamide derivative that inhibits stress-induces adrenal corticosteroid synthesis. Molecules, 14:3392-3410.
192. Fan J, Rone MB, Papadopoulos V (2009) Translocator Protein 2 (TSPO2) is involved in cholesterol redistribution during erythropoiesis. Journal of Biological Chemistry, 284:30484-30497.
193. Martinez–Arguelles DB, Culty M, Zirkin BR, Papadopoulos V (2009) In utero exposure to di-(2-ethylhexyl) phthalate decreases mineralocorticoid receptor expression in the adult testis. Endocrinology, 150:5575-5585.
194. Sakai M, Ferraz de Paula V, Pinheiro ML, Ribeiro A, Quinteiro-Filho WM, Rone MB, Martinez-Arguelles DB, Dagli MLZ, Papadopoulos V, Palermo-Neto J (2009) Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo. European Journal of Pharmacology, 626:131-138.
195. Tillement JP, Lecanu L, Papadopoulos V (2009) Amyloidosis and neurodegenerative diseases: current treatments and new pharmacological options. Pharmacology, 85:1-17.
196. Lecanu L, McCourty A, Sidahmed EK, Greeson J, Papadopoulos V (2010) Caprospinol reduces amyloid deposits and restores cognitive function. Neuroscience, 165:427-435.
197. Fan J, Liu J, Culty M, Papadopoulos V (2010) Acyl-coenzyme A binding domain containing protein ACBD3 (GCP60/PAP7): a new emerging signaling molecule. Progress in Lipid Research, 49:218-234.
198. Martinez-Arguelles DB, Papadopoulos V (2010) Epigenetic regulation of the expression of genes involved in steroid hormone biosynthesis and action. Steroids, 75:467-476.
199. Fan J, Traore, K, Li W, Amri H, Huang H, Wu C, Chen H, Zirkin B, Papadopoulos V (2010) Molecular mechanisms mediating the effect of mono- (2-ethylhexyl) phthalate (MEHP) on hormone-stimulated steroidogenesis in MA-10 mouse tumor Leydig cells.
Endocrinology, 151:3348-3362.
200. Batarseh A, Li J, Papadopoulos V (2010) Protein kinase Cε regulation of translocator protein (18-kDa) Tspo gene expression is mediated through a MAPK pathway targeting STAT3 and c-Jun transcription factors. Biochemistry, 49:4766-4778.
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201. Shah A, Lucero GR, Chana G, Masliah E, Achim CL, Lecanu L, Papadopoulos V, Greeson J, Everall IP (2010) Amelioration of caspase 3,7 activity by SP01 in human primary neurons exposed to HIV. Neurobehavioral HIV Medicine, 2:33-37.
202. Batarseh A, Papadopoulos V (2010) Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Molecular Cellular Endocrinology, 327:1-12.
203. Ostuni M, Péranzi G, Walker F, Issop L, Fasseu M, Elbim G, Papadopoulos V, Lacapere JJ (2010) Overexpression of Translocator protein TSPO in early stages of inflammatory bowel disease: involvement in diagnosis and treatment. Inflammatory Bowel Diseases, 16:1476-1487.
204. Lecanu L, Tillement L, McCourty A, Yao W, Greeson J, Papadopoulos V (2010) Dimethyl-carbamic acid 2,3-bis-dimethylcarbamoyloxy-6-(4-ethyl-piperazine-1-carbonyl)-phenyl ester: a multi-target therapeutic approach to neuroprotection. Medicinal Chemistry, 6:123-140.
205. Rupprecht R, Papadopoulos V, Rammes G, Baghai TC, Fan J, Akula N, Adams D, Groyer G, Schumacher M (2010) Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nature Reviews Drug Discovery, 9:971-988.
206. Tillement L, Lecanu L, Papadopoulos V (2011) Alzheimer’s disease: effects of beta-amyloid on the mitochondria. Mitochondrion, 11:13-21.
207. Rammouz G, Lecanu L, Aisen P, Papadopoulos V (2011) A lead study on oxidative stress-mediated dehydroepiandrosterone formation in serum: the biochemical basis for a diagnosis of Alzheimer's disease. Journal of Alzheimer’s Disease, 24 (Suppl 2):5-16.
208. Midzak A, Akula N, Lecanu L, Papadopoulos V (2011) Novel androstenetriol interacts with the mitochondrial Translocator protein and controls steroidogenesis. J Biological Chemistry, 286:9875-9887.
209. Midzak A, Rone M, Aghazadeh Y, Culty M, Papadopoulos V (2011) Mitochondrial protein import and the genesis of steroidogenic mitochondria. Molecular Cellular Endocrinology, 336:70-79.
210. Tillement L, Lecanu L, Papadopoulos V (2011) Further evidence on mitochondrial targeting of β-amyloid and specificity of β-amyloid-induced mitotoxicity in neurons. Neurodegenerative Diseases, 8:331-344.
211. Midzak AS, Chen H, Aon MA, Papadopoulos V, Zirkin BR (2011) ATP synthesis, mitochondrial function and steroid biosynthesis in primary and tumor Leydig cells. Biology of Reproduction, 84:976-985.
212. Martinez–Arguelles DB, Guichard T, Culty M, Zirkin BR, Papadopoulos V (2011) In utero exposure to the antiandrogen di-(2-ethylhexyl) phthalate decreases adrenal aldosterone production in the adult. Biology of Reproduction, 85:51-61.
213. Lecanu L, Ibrahim A, McCourty A, Giscos, Dinca I, Yao ZX, Xu J, Yao W, Vicini S, Szabo G, Erdélyi F, Greeson J, Papadopoulos V (2011) The naturally occurring steroid solasodine induces neurogenesis in vitro and in vivo. Neuroscience, 183:251-264.
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214. Castillo AF, Fan J, Papadopoulos V, Podestá EJ (2011) Hormone-dependent expression of a steroidogenic acute regulatory protein natural antisense transcript in MA-10 mouse tumor Leydig cells. PLOS One, 6:e22822.
215. Stanley E, Johnston D, Fan J, Papadopoulos V, Chen H, Ge R, Zirkin BR, Jelinsky S (2011) Stem Leydig cell differentiation: Gene expression during development of the adult population of Leydig cells. Biology of Reproduction, 85:1161-1166.
216. Batarseh A, Barlow KD, Martinez-Arguelles D, Papadopoulos V (2012) Functional characterization of human Translocator Protein (18 kDa) promoter in human breast cancer cell lines. Biochimica Biophysica Acta, 1819:38-56.
217. Campioli E, Batarseh A, Li J, Papadopoulos V (2012) The endocrine disruptor mono-(2-ethylhexyl) phthalate affects the differentiation of human liposarcoma cells (SW 872). PLOS One, 6:e28750.
218. Girard C, Liu Sm Adams A, Lacroix Cm Sineus M, Boucher C, Papadopoulos V, Rupprecht M, Schumacher M, Groyer G (2012) Axonal regeneration and neuroinflammation: roles for the translocator protein 18 KDa (TSPO). J Neuroendocrinology, 24:71-81.
219. Nothdurfter C, Rammes G, Baghai TC, Schüle C, Schumacher M, Papadopoulos V, Rupprecht R (2012) TSPO (18 kDa) as a target for novel anxiolytics with a favourable side-effect profile. J Neuroendocrinology, 24:82-92.
220. Papadopoulos V, Lecanu L (2012) Caprospinol: discovery of a drug candidate to treat Alzheimer’s disease based on 22R-hydroxycholesterol structure and properties. J Neuroendocrinology, 24:93-101.
221. Lecanu L, Hashim AI, McCourty A, Papadopoulos V (2012) A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo Steroids, 77:224-232.
222. Fan J, Lindemann P, Feuilloley M, Papadopoulos V (2012) Structural and functional evolution of the translocator protein (18 kDa). Current Molecular Medicine, 12:369-386.
223. Rammouz G, Lecanu L, Papadopoulos V (2012) Oxidative stress-mediated brain dehydroepiandrosterone (DHEA) formation in Alzheimer’s disease diagnosis. Frontiers in Endocrinology 2:69. doi: 10.3389/fendo.2011.00069.
224. Fan J, Papadopoulos V (2012) Transcriptional regulation of translocator protein (Tspo) via a SINE B2-mediated natural antisense transcript. Biology of Reproduction, 86:1-15.
225. Aghazadeh Y, Rone M, Hales DB, Blonder J, Veenstra T, Hales, DB, Culty M, Papadopoulos V (2012) Hormone-induced 14-3-3γ adaptor protein regulates steroidogenic acute regulatory protein activity and steroid biosynthesis in MA-10 Leydig cells. Journal of Biological Chemistry, 287:15380-15394.
226. Akula N, Midzak A, Lecanu L, Papadopoulos V (2012) Identification of small molecule inhibitors of the steroidogenic acute regulatory protein (STARD1) by structure-based design. Bioorganic & Medicinal Chemistry Letters, 22:4139-4143.
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227. Wang HJ, Fan J, Papadopoulos V (2012) Translocator protein (Tspo) gene promoter-driven green fluorescent protein synthesis in transgenic mice: an in vivo model to study Tspo transcription. Cell Tissue Research, 350:261-275.
228. Rone M, Midzak A, Issop L, Rammouz G, Jagannathan S, Fan J, Blonder J, Ye X, Veenstra TD, Papadopoulos V (2012) Identification of a dynamic mitochondrial protein complex driving cholesterol import, trafficking, and metabolism to steroid hormones. Molecular Endocrinology, 26:1868-1882
229. Midzak A, Rammouz G, Papadopoulos V (2012) Structure-activity relationship (SAR) analysis of a family of steroids acutely controlling steroidogenesis. Steroids, 77:1327-1334.
230. Ruksha T, Aksenenko M, Papadopoulos V (2012) Role of translocator protein in melanoma growth and progression. Archives Dermatological Research, 304:839-845.
231. Martinez–Arguelles DB, McIntosh M, Rohlicek C, Culty M, Zirkin BR, Papadopoulos V (2013) Maternal in utero exposure to the endocrine disruptor di-(2-ethylhexyl) phthalate affects the blood pressure of adult male offspring. Toxicology & Applied Pharmacology, 266:95-100.
232. Lecanu L, Yao ZX, McCourty A, Sidahmed E-K, Orellana ME, Burnier MN, Papadopoulos V (2013) Control of hypercholesterolemia and atherosclerosis using a peptide containing the cholesterol recognition/interaction amino acid consensus VLNYYVWR of the translocator protein TSPO. Steroids, 78:137-146.
233. Issop L, Rone MB, Papadopoulos V (2013) Organelle plasticity and interactions in cholesterol transport and steroid biosynthesis. Molecular Cellular Endocrinology, 371:34-46.
234. Martinez–Arguelles DB, Campioli E, Culty M, Zirkin BR, Papadopoulos V (2013) Fetal origin of endocrine dysfunction in the adult: the phthalate model. Journal of Steroid Biochemistry & Molecular Biology, 137:5-17.
235. Orlando U, Cooke M, Maciel FC, Papadopoulos V, Podesta EJ, Maloberti P (2013) Characterization of mouse promoter region for the acyl-CoA synthetase 4 gene: Role of Sp1 and CREB. Molecular Cellular Endocrinology, 369:15-26.
236. Beattie MC, Chen H, Fan J, Papadopoulos V, Miller P, Zirkin BR (2013) Aging and luteinizing hormone effects on reactive oxygen species production and DNA damage in Leydig cells. Biology of Reproduction, 88:100, 1-7.
237 Chung J-Y, Chen H, Midzak A, Burnett AL, Papadopoulos V, Zirkin BR (2013) Drug ligand-induced activation of Translocator protein (TSPO) stimulates steroid production by aged Brown Norway rat Leydig cells. Endocrinology, 154:2156-2165.
238 Lecanu L, Papadopoulos V (2013) Modeling Alzheimer’s disease with non-transgenic rat models. Alzheimer’s Research & Therapy, 5:17.
239. Gunosewoyo H, Midza A, Gaisin IN, Sabath EV, Fedolak A, Hanania T, Brunner D, Papadopoulos V, Kozikowski AP (2013) Characterization of maleimide-based glycogen synthase kinase-3 (GSK-3) inhibitors as stimulators of steroidogenesis. Journal of Medicinal Chemistry, 56:5115-5129.
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240. Zhou L, Beattie MC, Lin C-Y, Liu J, Papadopoulos V, Zirkin BR, Chen H (2013) Oxidative stress and phthalate-induced down-regulation of steroidogenesis in MA-10 Leydig cells. Reproductive Toxicology, 42:95-101.
241. Fan J, Papadopoulos V (2013) Evolutionary origin of the mitochondrial cholesterol transport machinery reveals a universal mechanism of steroid hormone biosynthesis in animals. PLOS One, 8(10):e76701.
242. Li J, Daly E, Campioli, E, Wabish M, Papadopoulos V (2014) De novo synthesis of steroids and oxysterols in adipocytes. Journal of Biological Chemistry, 289:747-764.
243. Papadopoulos V (2014) On the role of the translocator protein (18 kDa) TSPO in steroid hormone biosynthesis. Endocrinology, 155:15-20.
244. Samuelson LE, Anderson BM, Bai M, Dukes MJ, Hunt CR, Casey JD, Han Z, Papadopoulos V, Bornhop DJ (2014) A self-internalizing mitochondrial TSPO targeting imaging probe for fluorescence, MRI and EM. Royal Society of Chemistry Advances, 4:9003-9011.
245. Tillement JP, Papadopoulos V (2014) Subcellular injuries in Alzheimer's disease. CNS & Neurological Disorders-Drug Targets, 13:593-605.
246. Martinez–Arguelles DB, Campioli E, Lienhart C, Fan J, Culty M, Zirkin BR, Papadopoulos V (2014) In utero exposure to the endocrine disruptor di-(2-ethylhexyl) phthalate induces long-term changes in gene expression in the adult male adrenal gland. Endocrinology, 155:1667-1678.
247. Campioli E, Martinez-Arguelles DB, Papadopoulos V (2014) In utero exposure to the endocrine disruptor di-(2-ethylhexyl) phthalate promotes local adipose and systemic inflammation in the adult male offspring. Nutrition & Diabetes, 4:e115.
248. Midzak A, Papadopoulos V (2014). Binding domain-driven intracellular trafficking of sterols for synthesis of steroid hormones, bile acids and oxysterols. Traffic, 15:895-914.
249. Azarashvili T, Baburina Y, Grachev D, Krestinina O, Papadopoulos V, Odinokova I, Reiser G (2014) Carbenoxolone induces mitochondrial permeability transition pore opening in rat mitochondria acting via the translocator protein TSPO and connexin 43. Archived Biochemistry Biophysics, 558:87-94.
250. Martinez-Arguelles DM, Lee S, Papadopoulos V (2014) In silico analysis identifies novel restriction enzyme combinations that expand reduced representation bisulfite sequencing epigenomic coverage. BMC Research Notes, 7:354.
251. Aghazadeh Y, Martinez-Arguelles DB, Fan J, Culty M, Papadopoulos V (2014) Induction of androgen formation in the male by a TAT-VDAC1 fusion peptide blocking 14-3-3ε protein adaptor and mitochondrial VDAC1 interactions. Molecular Therapy (Nature), 22:1779-1791.
252. Aghazadeh Y, Blonder J, Papadopoulos V (2014) Protein modifications regulate the role of 14-3-3γ adaptor protein in cAMP-induced steroidogenesis in MA-10 Leydig cells. Journal of Biological Chemistry, 289:26542-26553.
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253. Rone MB, Midzak AS, Martinez-Arguelles DM, Fan J, Ye J, Blonder J, Papadopoulos V (2014) Alteration of the mitochondrial fatty acid import machinery upon hormonal stimulation in MA-10 mouse Leydig cells. Biology of Reproduction, 91(4):1-14.
254. Leneveu-Jenvrin C, Bouffartigues E, Connil N, Bouffartigues E, Papadopoulos V, Feuilloley MGJ, Chevalier S (2014) Structure to function relationships of bacterial translocator protein (TSPO): a focus on Pseudomonas. Frontiers in Microbiology, 5:631.
255. Meltzer D, Martinez-Arguelles DM, Campioli E, Lee S, Papadopoulos V (2014) In utero exposure to the endocrine disruptor di(2-ethylhexyl) phthalate targets ovarian theca cells and steroidogenesis in the adult female rat. Reproductive Toxicology, 51:47-56.
256. Martinez–Arguelles DB, Papadopoulos V (2015) Identification of hot spots of DNA methylation in the adult male adrenal in response to in utero exposure to the ubiquitous endocrine disruptor plasticizer di-(2-ethylhexyl) phthalate. Endocrinology, 156:124-133.
257. Issop L, Fan J, Lee S, Rone MB, Basu K, Mui J, Papadopoulos V (2015) Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: Role of ATAD3. Endocrinology, 156:334-345.
258. Sakai M, Martinez-Arguelles DM, Patterson NH, Chaurand P, Papadopoulos V (2015) In search of the molecular mechanisms mediating the inhibitory effect of the GnRH antagonist degarelix on human prostate cell growth. PLOS One, 10(3):e0120670.
259. Martinez–Arguelles D, Papadopoulos V (2015) Mechanisms mediating environmental chemical-induced endocrine disruption in the adrenal gland. Frontiers in Endocrinology, 6:29.
260. Papadopoulos V, Aghazadeh Y, Fan J, Campioli, E., Zirkin BR, Midzak A (2015) Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis. Molecular & Cellular Endocrinology, 408:90-98.
261. Campioli E, Duong TB, Deschamps F, Papadopoulos V (2015) Cyclohexane-1, 2-dicarboxylic acid diisononyl ester and metabolite effects on rat epididymal stromal vascular fraction differentiation of adipose tissue. Environmental Research, 140:145-156. (Erratum; Environmental Research, 2016, 144:170-171).
263. Midzak AS, Akula N, Rone MB, Papadopoulos V (2015) Computational modeling and biological validation of novel non-steroidal ligands for the cholesterol recognition / interaction amino acid consensus (CRAC) motif of the mitochondrial translocator protein (TSPO). Pharmacological Research, 99C:393-403.
264. Mavrogonatou E, Papadimitriou K, Urban JP, Papadopoulos V, Kletsas K (2015) Transcritpomics analysis sheds light on new transporting molecules regulating the osmotic adaptive response of nucleus pulpous intervertebral disc cells. Journal of Cell Physiology, 230:3037-3048.
265. Midzak A, Denora N, Laquintana V, Cutrignelli A, Lopedota A, Franco M, Altomare CD, Papadopoulos V (2015) 2-phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in
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a mouse Leydig tumor cell line. European Journal of Pharmaceutical Sciences, 76:231-237.
266. Chen H, Guo J, Ge R, Papadopoulos V, Zirkin BR (2015) Steroidogenic fate of the Leydig cells that repopulate the testes of young and aged Brown Norway rats after elimination of the preexisting Leydig cells. Experimental Gerontology, 72:8-15.
267. Fan J, Midzak A, Campioli E, Culty M, Papadopoulos V (2015) Conditional steroidogenic cell-targeted deletion of the translocator protein (TSPO, 18-kDa) unveil its crucial role in viability and hormone-dependent steroid formation. Proceedings of the National Academy of Sciences (USA), 112:7261-7266.
268. Li J and Papadopoulos V (2015) Translocator protein (18 kDa) as a pharmacological target in adipocytes to regulate glucose homeostasis. Biochemical Pharmacology, 97:99-110.
269. Li J, Papadopoulos V, Veera V (2015) Steroid biosynthesis in adipose tissue. Steroids, 103:89-104.
270. Culty M, Liu Y, Manku G, Chan WY, Papadopoulos V (2015) Expression of steroidogenesis-related genes in murine male germ cells. Steroids, 103:105-114.
271. Sakai M, Elhilali M, Papadopoulos V (2015) The GnRH antagonist Degarelix directly inhibits benign prostate hyperplasia cell growth. Hormone & Metabolic Research, 47:925-931.
272. Azarashvili T, Krestinina O, Baburina Y, Odinokova I, Grachev D, Papadopoulos V, Akatov V, Lemasters J, Reiser G (2015) Combined effect of G3139 and TSPO ligands on Ca2+-induced permeability transition in rat brain mitochondria Archives of Biochemistry and Biophysics, 587:70-77.
273. Herrera-Rivero M, Heneka M, Papadopoulos V (2015) Translocator protein and new targets for neuroinflammation. Clinical and Translational Imaging, 3:391-402.
274. Campioli E, Papadopoulos V (2016) Cyclohexane-1,2-dicarboxylic acid diisononyl ester and metabolite effects on rat epididymal stromal vascular fraction differentiation of adipose tissue. Letter to the Editor; Reply to Otter R. Environmental Research, 144:167-169.
275. Aghazadeh Y, Papadopoulos V (2016) The role of the 14-3-3 protein family in health, disease, and drug development. Drug Discovery Today, 21:278-287.
276. Li NC, Fan J, Papadopoulos V (2016) Sterol Carrier Protein-2, a nonspecific lipid-transfer protein, in intracellular cholesterol trafficking in testicular Leydig cells. PLOS One, 11(2):e0149728.
277. Sakai M, Martinez-Arguelles DM, Aprikian AG, Magliocco AM, Papadopoulos V (2016) De novo steroid biosynthesis in human prostate cell lines and biopsies. Prostate, 76:575-587.
278. Issop L, Ostuni M, Lee S, Laforge M, Péranzi G, Rustin P, Benoist J-F, Estaquier J, Papadopoulos V, Lacapère JJ (2016) Translocator protein-mediated stabilization of mitochondrial architecture during inflammation stress in colonic cells. PLOS One,
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11(4):e0152919.
279. Traore K, Martinez-Arguelles DB, Papadopoulos V, Chen HL, Zirkin BR (2016) Repeated exposures of the male Sprague Dawley rat reproductive tract to environmental toxicants: do earlier exposures to di-(2-ethylhexyl) phthalate (DEHP) alter the effects of later exposures? Reproductive Toxicology, 61:136-141.
280. Martinez-Arguelles DB, Papadopoulos V (2016) Prenatal phthalate exposure: epigenetic changes leading to lifelong impact on steroid formation. Andrology, 4:573-584.
281. Jones S, Boisvert A, Naghi A, Hullin−Matsuda F, Greimel P, Kobayashi T, Papadopoulos V, Culty M (2016) Stimulatory effects of cobined endocrine disprutors on MA-10 leydig cell steroid production and lipid homeostasis. Toxicology, 355:21-30.
282. Fan J, Li X, Issop L, Culty M, Papadopoulos V (2016) ACBD2/ECI2-mediated peroxisomes-mitochondria interactions in Leydig cell steroid biosynthesis. Molecular Endocrinology, 30:763-782.
283. Boisvert A, Jones S, Issop L, Erythropel HC, Papadopoulos V, Culty M (2016) In vitro functional screening as a mean to identify new plasticizers devoid of reproductive toxicity. Environmental Research, 150:496-512.
284. Midzak A, Papadopoulos V (2016) Adrenal mitochondria and steroidogenesis: from individual proteins to functional protein assemblies. Frontiers in Endocrinology, 7:106. doi: 10.3389/fendo.2016.00106.
285. Venugopal S, Martinez-Arguelles DB, Chebbi S, Hullin-Matsuda F, Kobayashi T, Papadopoulos V (2016) Plasma membrane origin of the steroidogenic pool of cholesterol used in hormone-induced acute steroid formation in Leydig cells. J Biological Chemistry, 291:26109-26125.
286. Azarashvili T, Krestinina O, Baburina I, Odinokova I, Akatov V, Reiser G, Lemasters J, and Papadopoulos V (2016) Effect of CRAC peptide VLNYYVW on mPTP opening in rat brain and liver mitochondria. International Journal of Molecular Sciences, 17(12):E2096.
287. Lee S, Martinez–Arguelles DB, Campioli E, Papadopoulos V (2017) Fetal exposure to low levels of the plasticizer DEHP predisposes the adult male adrenal gland for endocrine disruption. Endocrinology, 158:304-318.
F. Invited non-peer reviewed reviews, book chapters and editorials:
1. Papadopoulos V, Drosdowsky MA, Carreau S (1986). Effects of leukotriene B4 (LTB4) on purified rat Leydig cell steroidogenesis. In "Molecular and Cellular Endocrinology of the Testis", M. Stefanini et al, Eds. Elsevier Science Publishers, 261-264.
2. Papadopoulos V, Drosdowsky MA, Carreau S (1987). On the existence of two Leydig cell populations in human aged testis. Annals of New York Academy of Science, 153:356-358.
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3. Almahbobi G, Papadopoulos V, Carreau S, Silberzahn P (1987). Two successive different populations of Leydig cells during equine testes maturation. Annals of New York Academy of Science, 153:359-361.
4. Carreau S, V. Papadopoulos V, Kamtchouing P, Drosdowsky MA (1988). The rat seminiferous tubules secrete factor(s) which modulate the Leydig cell function: age related effects. Serono Symposia, 14:211-214.
5. Hall PF, Papadopoulos V, Yanagibashi K (1988). On the mechanism of action of ACTH. In: "Progress in Endocrinology 1988", H. Imura et al, Eds, Elsevier Sci. Publ., 253-258.
6. Krueger KE, Papadopoulos V (1991). The peripheral-type benzodiazepine receptor: cell biological role and pharmacological significance. FIDIA Research Foundation Symposium Series, "Transmitter amino acid receptors: structures, transduction and models for drug development", Thieme Med. Publ. Inc., 6:153-166.
7. Papadopoulos V (1991). Hormone-stimulated steroidogenesis is coupled to mitochondrial benzodiazepine receptors. In: "Biological Psychiatry" G. Racagni et al. Eds, Elsevier Sci. Publ., 1:742-743.
8. Krueger KE, Papadopoulos V (1991). Molecular and functional characterization of peripheral-type benzodiazepine receptors in glial cells. In: "Biological Psychiatry", G. Racagni et al. Eds, Elsevier Sci. Publ., 1:744-746.
9. Papadopoulos V, Guarneri P, Pan B, Krueger KE, Costa E (1991). Steroid synthesis by glial cells. FIDIA Research Foundation Symposia Series, 8:165-170.
10. Krueger KE, Whalin M, Papadopoulos V (1991). Regulation of steroid synthesis in adrenals by mitochondrial benzodiazepine receptors. FIDIA Research Foundation Symposia Series, 8:155-160.
11. Costa E, Romeo E, Auta J, Papadopoulos V, Guidotti A, Kozikowski A (1991). Is there a pharmacology of brain steroidogenesis? FIDIA Research Foundation Symposia Series, 8:171-176.
12. Costa E, Guidotti A, Krueger KE, Mereu G, V. Papadopoulos V, Puia G, Vicini S (1992) Benzodiazepine receptor complexes: Structures, mechanisms, and molecular pharmacology. New leads and targets in drug research. Krogsgaard-Larsen P, Brogger-Christensen S, Kofold H (eds). Copenhagen: Munksgaard, 164-173.
13. Krueger KE, Papadopoulos V (1992). Mitochondrial benzodiazepine receptors and the regulation of steroid biosynthesis. Annual Review of Pharmacology & Toxicology, 32:211-237.
14. Krueger KE, Papadopoulos V (1993). The role of mitochondrial benzodiazepine receptors in steroidogenesis. In: "Peripheral benzodiazepine receptors" E. Giesen-Crouse, ed. Academic Press, pp. 89-109.
15. Krueger KE, Papadopoulos V (1993). Cellular role and pharmacological implications of mitochondrial P-sites recognizing diazepam binding inhibitor (DBI) as a putative endogenous ligand. Imidazopyridines In Anxiety Disorders: A Novel Experimental And Therapeutic Approach G. Bartholini, M. Garreau, P.L. Morselli, and B. Zivkovic eds., Raven Press, 39-48.
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16. Boujrad N, Hudson JR, Papadopoulos V (1993). The polypeptide diazepam binding inhibitor mediates the hormonal stimulation of steroidogenesis. Serono Symposia, Springer Verlag New York Publ., pp 186-194.
17. Papadopoulos V, Boujrad N, Ikonomovic MD, Vidic B (1994) Topography of the mitochondrial peripheral-type benzodiazepine receptor by atomic force microscopy. Editions Physique 3B:773-774.
18. Papadopoulos V, Brown AS, Vidic B, Garnier M, Gaillard J-L, Lee C-H, Dimchev AB, Ogwuegbu SO, Amri H, Boujrad N (1996) Diazepam binding inhibitor and peripheral-type benzodiazepine receptor: Role in steroid biosynthesis, in Cellular and Molecular Regulation of Testicular Cells, Serono Symposia, Springer Verlag New York Publ., pp.337-356.
19. Papadopoulos V (1996) Pharmacologic influence on androgen biosynthesis, in The Leydig Cell, edited by Russell, Hardy and Payne, Cache River Press, pp. 597-628.
20. Amri H, Drieu K, Papadopoulos V (1997) Regulation of peripheral benzodiazepine receptor, glucocorticoid synthesis and neuroprotection by the Ginkgo biloba extract EGb 761 and isolated ginkgolide B. Advances in Ginkgo Biloba Research, 6:117-127.
21. Papadopoulos V, Brown RC, Cascio C (1997) Neurosteroids and peripheral benzodiazepine receptor. European Neuropsychopharm. 7:S79-80.
22. Papadopoulos V (1998) Intratesticular regulation of Leydig cell function. In “Progress in Biology and Pathology on Male Reproduction” edited by Martinez F and Regadera J, Churchill Communications, Madrid, Spain, 97-111.
23. Papadopoulos V (1998) New aspects in the regulation of steroid biosynthesis. Role of the peripheral-type benzodiazepine receptor. In “Progress in Biology and Pathology on Male Reproduction” edited by Martinez F and Regadera J, Churchill Communications, Madrid, Spain, 165-181.
24. Vidic B, Boujrad N, Papadopoulos V (1998) Acute action of choriogonadotropin on Leydig tumor cells: Qualitative and quantitative transformation of lipid moieties. Folia Anatomica 26 (suppl. 2):16-22.
25. Yao Z, Boujrad N, Drieu K, Papadopoulos V (1998) Protection of the cytochrome P450scc enzyme and steroidogenic ability of Leydig cells by Ginkgolide B. Advances in Ginkgo Biloba Research, 7:129-138.
26. Cascio C, Guarneri P, Li H, Brown RC, Amri H, Boujrad N, Kotoula M, Vidic B, Drieu K, Papadopoulos V (1999) Peripheral-type benzodiazepine receptor. Role in the regulation of steroid and neurosteroid biosynthesis. In “Neurosteroids: A New Regulatory Function in the Central Nervous System” Contemporary Endocrinology, edited by EE. Baulieu, P. Robel, & M. Schumacher, The Humana Press Inc., 75-96.
27. Lindemann P, Koch A, Hause G, Papadopoulos V, Luckner M (2000) Evidence for a benzodiazepine binding protein in plants. In: Okamoto M, Ishimura Y, Nawata H (eds) Molecular Steroidogenesis, Proceedings of the 52nd Yamada Conference, Universal Academy Press (ISBN: 4-946443-54-1). Yamada Science Foundation, 297-300.
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28. Brown RC, Cascio C, Papadopoulos V (2000) Neurosteroid biosynthesis and regulation in human brain. In: Okamoto M, Ishimura Y, Nawata H (eds) Molecular Steroidogenesis, Proceedings of the 52nd Yamada Conference, Universal Academy Press (ISBN: 4-946443-54-1). Yamada Science Foundation, 381-384.
29. Brown RC, Papadopoulos V (2001) Role of peripheral benzodiazepine receptors in adrenal and brain steroidogenesis. International Review of Neurobiology, 46:117-144.
30. Papadopoulos V, Amri H, Li H, Yao Z, Brown RC, Vidic B, Culty M (2001) Structure, function and regulation of the mitochondrial peripheral-type benzodiazepine receptor. Therapie, 56:549-556.
31. Brown RC, Liu Y, Papadopoulos V (2002) Brain dehydroepiandrosterone: biosynthesis and regulation. In DHEA and Brain, Morfin R (ed), Taylor and Francis, London 129-146.
32. Hauet T, Liu J, Li H, Gazouli M, Culty M, Papadopoulos V (2002) PBR, StAR and PKA: partners in cholesterol transport in steroidogenic cells. Endocrine Research, 28:399-405.
33. Papadopoulos V (2003) Peripheral benzodiazepine receptor: structure and function in health and disease. Annales Pharmaceutiques Francaises, 61:30-50.
34. Liu J, Li H, Papadopoulos V (2003) PAP7, a PBR/PKA-RIα-associated protein: a new element in the relay of the hormonal induction of steroidogenesis. J Steroid Biochemistry & Molecular Biology, 85: 275-283.
35. Papadopoulos V (2004) In search of the function of the peripheral-type benzodiazepine receptor. Endocrine Research, 30:677-684.
36. Habert R, Papadopoulos V (2005) Memorial: Jose M. Saez, M.D. (1934–2003). Molecular Cellular Endocrinology 229:1-2.
37. Papadopoulos V (2005) Cholesterol homeostasis and infertility: the liver X receptor connection. Endocrinology, 146:2517-2518.
38. Liu Y, Papadopoulos V (2005) Biosynthesis and regulation of dehydroepiandrosterone in brain. Proceedings of the Catalan Society of Biology, Reventos J (ed,) Endocrinologia Molecular, 56: 135-145.
39. Papadopoulos V (2006) Environmental factors that disrupt Leydig cell steroidogenesis, in Contemporary Endocrinology: The Leydig Cell in Health and Disease, edited by Payne AH and Hardy MP, Humana Press, Totowa, NJ, pp. 393-413.
40. Ostuni MA, Walker F, Papadopoulos V, Lacapere JJ (2006) Le récepteur péripherique aux benzodiazépines (PBR), un marqueur de l’inflammation? Gastroent Clin Biol 30:717.
41. Mishra B, Gearhart J, Papadopoulos V (2008) Stem Cells and Disease. Dis Markers 24:199-200.
42. Zirkin BR, Papadopoulos V, Hardy MP (2009) Leydig cell development and function. In Infertility in the Male, 4th ed, edited by Lipshultz L, Howard S and Niederberger G, Cambridge University Press, pp. 20-47.
43. Papadopoulos V (2010) How is the synthesis of testosterone regulated? In Handbook of Andrology, 2nd ed, edited by Robaire B and Chan P, Allen Press, pp. 5.1-4.
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44. Lecanu L, Papadopoulos V (2010) Alzheimer’s disease drug discovery: Potential therapeutic strategies and future treatments. Frontiers in CNS Drug Discovery, 1:123-146.
45. Papadopoulos V (2011) From benzodiazepines to peripheral and brain steroid biosynthesis. Pharmacological Research, 64:330-332.
46. Papadopoulos V (2011) Implications of new diagnostic blood test for Alzheimer’s disease on future disease management. Neurodegenerative Disease Management, 1:345-348.
47. Papadopoulos V, Lecanu L (2012) Les neurosteroids dans la maladie d’Alzheimer. In “La Maladie d’Alzheimer aujourd’hui” Editors: Tillement JP, Haw JJ, Papadopoulos V. Lavoisier, Paris, France.
48. Papadopoulos V, Miller WL (2012) Role of mitochondria in steroidogenesis. Best Practice & Research Clinical Endocrinology & Metabolism, 26:771-790.
49. Hill D, Papadopoulos V, Saryeddine T (2013) Reclaiming Canada’s capacity to attract the human, social and economic benefits of clinical trials. Inside Policy. The Magazine of the McDonald-Laurier Institute, Ottawa, Canada, September issue, p.24-26.
50. Lacapere JJ, Iatmanen-Harbi S, Senicourt L, Lequin O, Tekely P, Purusottam RN, Hellwig P, Kriegel S, Ravaud S, Juillan-Binard C, Pebay Peyroula E, Papadopoulos V (2014) Structural studies of the mitochondrial membrane translocator protein. In: “Membrane proteins production for structural analysis" Mus-Veteau I (editor), Springer Inc.; p.393-421.
51. Tillement JP, Hauw JJ, Papadopoulos V, Montastruc JL (2015) Vieillissement et démences: un défi médical, scientifique et socio-économique. Therapie, 70:239.
52. Aghazadeh Y, Zirkin BR, Papadopoulos V (2015) Pharmacological regulation of the cholesterol transport machinery in steroidogenic cells of the testis. In: Hormones and Transport Systems, Liwack G (editor). Vitamins & Hormones, 98:189-227.
53. Midzak A, Zirkin BR, Papadopoulos V (2015) Translocator protein: pharmacology and steroidogenesis. Biochemical Society Transactions, 43:572-578.
54. Midzak A, Papadopoulos V (2015) Steroiodgenesis: the classics and beyond. Steroids, 103:1-2.
55. Zirkin, BR, Chen H, Papadopoulos V (2017) Leydig cell development and aging in the Brown-Norway rat: mechanisms and consequences. In “Conn’s Handbook of Models for Human Aging” Editor: Conn PM, in press.
Total peer-reviewed and non-peer-reviewed publications: 342
G. Books and Special Issues Edited:
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1. “Adaptive Effects of Ginkgo Biloba Extract (EGB 761)”, volume 6 of the Advances of Ginkgo Biloba Research, Editor: Papadopoulos V, Elsevier, Paris, 1997.
4. “Vieillissement et démences, un triple défi médical, social et économique” Editors: Tillement JP, Haw JJ, Papadopoulos V. Lavoisier, Paris, 2014.
5. ”Steroidogenesis: The Classics & Beyond”, Special issue of Steroids, Editors: Papadopoulos V, Midzak A, Elsevier, 2015.
H. Abstracts Presented in National and International Meetings:
1. Joly E, V. Papadopoulos, S. Carreau and M.A. Drosdowsky (1984). In vitro localization of rat testicular aromatase activity "revisited". Third European Workshop oh Molecular and Cellular Endorcrinology of the Testis, Lyon, France, April 26-29.
2. Papadopoulos V, S. Carreau and M.A. Drosdowsky (1984). LH regulation of steroidogenesis in Guinea-pig Leydig cells involves phospholipid methylation and cytoskeletal organization. 12th Annual Meeting of the Greek Endocrine Society, Athens, Greece, December 8-9.
3. Papadopoulos V, S. Carreau and M.A. Drosdowsky (1984). Steroidogenic effect of exogenous phopholipase C on purified rat Leydig cells. 12th Annual Meeting of the Greek Endocrine Society, Athens, Greece, December 8-9.
4. Carreau S, V. Papadopoulos and M.A. Drosdowsky (1985). LH-regulation of steroidogenesis in Guinea-pig Leydig cells. 5th Anglo-French Meeting of the Society for the Study of Fertility, Paris, France, December 7-9, J. Rerod. Fertility, 75:294.
5. Drosdowsky MA, V. Papadopoulos and S. Carreau (1985). Regulation of rat Leydig cell aromatase activity by seminiferous tubules secreted factors. 3rd International Congress of Andrology, Boston, MA., U.S.A., April 27- May 2. J. Andrology, 6(Sup):2 abstract no. F-5.
6. Carreau S, V. Papadopoulos and M.A. Drosdowsky (1985). Donnees recentes sur les mecanismes d'action de la LH au niveau Leydigien. 3e Forum International d'Andologie, Paris, France, June 18-19.
7. Drosdowsky MA, V. Papadopoulos, S. Carreau (1985). Role de la testosterone intratesticulaire. 3e Forum International d'Anrologie, Paris, France, June 18-19.
8. Carreau S, V. Papadopoulos, M.A.Drosdowsky (1985). Implication of membrane and cytosolic methylation processes in the regulation of rat Leydig cell steroidogenesis. XV Acta Endocrinologica Congress, Helsinki, Finland, August 2-4. Acta Endocrinologica, 109(Suppl. 270):201.
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9. Carreau S, V. Papadopoulos, M.A. Drosdowsky (1985). Rat Leydig cell aromatase activity: Regulation by seminiferous tubules secreted factor(s). XV Acta Endocrinologica Congress, Satellite Symposium: Novel Aspects in the Hormonal Regulation of Testicular Function, Helsinki, Finland, August 2-4. Acta Endocrinologica, 109(Suppl. 270):212.
10. Papadopoulos V, S. Carreau and M.A. Drosdowsky (1985). Implication de la proteine kinase C dans la regulation de la steroidogenese Leydigienne chez le rat. V Congress Francais d'Endocrinologie, Bordeaux, France, 3-5 October. Annal. Endocrinol., 46:130.
11. Benhaim A, V. Papadopoulos, H. Mittre et P. Leymarie (1985). Prostaglandine F2a (PGF2a) et cellules luteales bovines "in vitro". Societe Francaise pour L'Etude de la Fertilite, Paris, France, 28-29 June.
12. Carreau S, V. Papadopoulos, M.A. Drosdowsky (1985). L'aromatase des cellules de Leydig du rat: regulation par des facteurs secretes par les tubes seminiferes. S.A.L.F., Bordeaux, France, 13-14 December.
13. Drosdowsky MA, P. Barbey, S. Fradin, V. Papadopoulos and S. Carreau (1985). Intragonadal regulation of spermatogenesis. International Symposium of Fertility Regulation Research, Pekin, China, November 28-30 April.
14. Papadopoulos V, S. Carreau, E. Szerman-Joly, M.A. Drosdowsky and L. Dehennin (1985). Biosynthese de l'oestradiol dans le testicule de rat. Evolution en fonction de l'age. Meeting of Fondation de Recherche en Hormonologie, Paris, France, Pathologie Biologie, 33:10.
15. Kamtchouing P, V. Papadopoulos, M.A. Drosdowsky, M.T. Hochereau de Reviers and S. Carreau (1986). Correlation between ABP levels and testicular morphometric studies in rats either normal or irradiated or hemicastrated. 1st International Symposium of Binding Proteins: Steroid Hormones, Lyon, France, 28-30 April.
16. Argyriou A, V. Papadopoulos, P. Barbey, S. Carreau and M.A. Drosdowsky (1986). Etude en HPLC de la biosynthese des steroides dans les cellules de Leydig purifiees du rat normal et irradie. 13th Annual Meeting of the Greek Endocrine Society, Greece, 5-6 April.
17. Carreau S, V. Papadopoulos, M.A. Drosdowsky (1986). Induction of adult rat Leydig cell aromatase activity by Sertoli cell factor(s). IV European Workshop on Molecular and Cellular Endocrinology of the Testis. Capri, Italy, 9-12 April.
18. Papadopoulos V, M.T. Hochereau de Reviers, M.A. Drosdowsky, S. Carreau (1986). Stage dependent regulation of rat Leydig cell function by seminiferous tubules in vitro. IV European Workshop on Molecular Endocrinology of the Testis. Capri, Italy, 9-12 April.
19. Papadopoulos V, S. Carreau, P. Kamtchouing, M.A. Drosdowsky (1986). Effects of a phorbol ester on immature rat Sertoli cell functions. IV European Workshop on Molecular Endocrinology of the Testis. Capri, Italy, 9-12 April.
20. Papadopoulos V, M.A. Drosdowsky, S. Carreau (1986). Effect of leukotriene B (LTB) on purified rat Leydig cell steroidogenesis. IV European Workshop on Molecular Endocrinology of the Testis. Capri, Italy, 9-12 April.
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21. Papadopoulos V, S. Carreau, C. Pisselet, M.T. Hochereau de Reviers, C. Perreau, B. Schanbacher (1986). Comparisons of ovine desteroidized plasma from testicular artery or vein and lymph on testosterone and cyclic AMP productions by purified Leydig cells in vitro. IV European Workshop on Molecular Endocrinology of the Testis. Capri, Italy, 9-12 April.
22. Papadopoulos V, M.A. Drosdowsky and S. Carreau (1986). On the existence of two Leydig cell populations in human testis. Endocrine Society Annual Meeting, Anaheim, U.S.A., Abstract No. 846
23. Carreau S, V. Papadopoulos, M.A. Drosdowsky (1986). Purification des cellules de Leydig humaines: mise en evidence de deux populations cellulaires fonctionelles. VI Congres Francais d'Endocrinologie, Nice, France, 2-4 October. Annal. Endocrinol., 47:286.
24. Papadopoulos V, M.A. Drosdowsky, and S. Carreau (1986). On the existence of two Leydig cell populations in human testis. Testis Workshop, Nashville, U.S.A., 14-17 October.
25. Almahbobi G, V. Papadopoulos, S. Carreau, P. Silberzahn (1986). Two successive different populations of Leydig cells during equine testes maturation. Testis Workshop, Nashville, U.S.A., 14-17 October.
26. Dorsdowsky MA, V. Papadopoulos, M.T. Hochereau de Reviers and S. Carreau (1986). Regulation stade-dependent de la fonction leydigienne par le tube seminifere in vitro. IV Congres, Societe d'Andrologie de la langue Francaise (SALF), Brazzaville, Congo, 19-21 December.
27. Papadopoulos V, M.A. Drosdowsky and S. Carreau (1986). Presence de 2 populations de cellules de Leydig dans le testicule humaine. IV Congres, Societe d'Andrologie de la langue Francaise (SALF), Brazzaville, Congo, 19-21 December.
28. Carreau S, V. Papadopoulos, L. Dehennin, M.A. Drosdowsky (1987). Regulation paracrine de l'aromatase Leydigienne chez le rat. Meeting of "Fondation de Recherche en Hormonologie", Paris, France, Pathologie Biologie, 35:1135-1136.
29. Papadopoulos V, S. Carreau and M.A. Drosdowsky (1987). The adult rat Leydig cell aromatase activity is stimulated by a Serotli cell factor. Aromatase: Future Perspectives, Miami, Florida, U.S.A., 4-7 March.
30. Papadopoulos V, M.A. Drosdowsky and S. Carreau (1987). Comparative studies between crude interstitial cells and purified Leydig cells in human testis. 14th Annual Meeting of the Greek Endocrine Society, Thessaloniki, Greece, 8-10 April.
31. Argyriou A, V. Papadopoulos, S. Carreau and M.A. Drosdowsky (1987). In vitro effects of enzymatic cofactors on Testosterone (T) production by human testes. 14th Annual Meeting of the Greek Endocrine Society, Thessaloniki, Greece, 8-10 April.
32. Carreau S, V. Papadopoulos and M.A. Drosdowsky (1987). Effects of cisplatin and bleomycin on mature rat Leydig cell testosterone production. 8th Congress of the Journal of Steroid Biochemistry. Paris, France, 24-27 May.
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33. Papadopoulos V, P. Kamtchouing, C. Pisselet, C. Perreau, M.T. Hochereau de Reviers and S. Carreau (1987). LH/hCG receptor binding inhibitor (LH-RBI) in ovine testicular vein plasma. VII Workshop on Development and Function of the Reproductive Organs. Turku, Finland, 10-12 June.
34. Carreau S, V. Papadopoulos, P. Kamtchouing and M.A. Drosdowsky (1987). The rat seminiferous tubules secrete factor(s) which modulate Leydig cell function: age related effects. VII Workshop on Development and Function of the Reproductive Organs. Turku, Finland, 10-12 June.
35. Carreau S and V. Papadopoulos (1987). A Sertoli cell protein (CMB-21) stimulates testosterone synthesis in immature rat Leydig cells. Endocrine Society Annual Meeting, Indianapolis, U.S.A., Abstract no. 429.
36. Papadopoulos V, A.S. Brown and P.F. Hall (1987). A calmodulin dependent protein kinase associated with the cytoskeleton of adrenal cells. Endocrine Society of Australia, Sydney, Australia, 24-26 August.
37. Brown AS, V. Papadopoulos and P.F. Hall (1987). Dual effect of Amphotericin B on adrenal cell steroidogenesis. Endocrine Society of Australia, Sydney, Australia, 24-26 August.
38. Papadopoulos V, S. Carreau, C.Y. Cheng and C.W. Bardin (1987). Stimulation of immature rat Leydig cell testosterone synthesis by a protein purified from primary Sertoli cell cultrue medium. Australian Society of Reproductive Biology Meeting, Sydney, Australia, 24-26 August.
39. Hall PF, A.S. Brown and V. Papadopoulos (1988). Isolation and characterization of calcineurin (Ca2+/calmodulin dependent phosphatase) from adrenal cells. Endocrine Society of Australia, Canberra, Australia, 10-12 February.
40. Papadopoulos V, and P.F. Hall (1988). The protein kinase C in regulation of adrenal steroid synthesis. Endocrine Society of Australia, Canberra, Australia, 10-12 February.
41. Papadopoulos V, S.Carreau, C. Pisselet, C. Perreau, M.A. Drosdowsky and M.T. Hochereau de Reviers (1988). Inhibition of rat Leydig cell function by a factor obtained from ram testis. Vth European Workshop on Molecular and Cellular Endocrinology of the Testis, Brighton, U.K., 13-16 April.
42. Kamtchouing P, V. Papadopoulos, S. Carreau, M.T. Hochereau de Reviers and M.A. Drosdowsky (1988). The Hypodactyl Rat: a useful model to study the interactions between Sertoli and Leydig cells. Vth European Workshop on Molecular and Cellular Endocrinolgy of the Testis, Brighton, U.K., 13-16 April.
43. Papadopoulos V, C. Pisselet, C. Perreau, M.A. Drosdowsky, M.T. Hochereau de Reviers and S. Carreau (1988). Evidence for a high molecular weight LH binding inhibitor in ovine testis. Endocrine Society Annual Meeting, New Orleans, U.S.A., Abstract No. 852.
44. Papadopoulos V, M.A. Drosdowsky and S. Carreau (1988) Paracrine factors on Leydig cell function. International Syposium on Recent Advances in Male Reproduction, Hyderabad, India, 12-14 July.
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45. Papadopoulos V and P.F. Hall (1988). Role of protein kinase C in adrenal steroidogenesis. 8th International Congress of Endocrinology, Kyoto, Japan, 17-23 July.
46. Jones MR, M.J. Marsh, V. Papadopoulos, B.L. McDonald, J.R. Bassett, R.M. Hoskinson, and P.C. Wynn (1989). Localization of ACTH receptor on mouse Y-1 cells with antibodies induced by a peptide encoded by RNA complementary to ACTH mRNA. Australian New Zealand Society of Cell Biology, annual meeting, Sydney, Australia.
47. Papadopoulos V, A.S. Brown and P.F. Hall (1989). Ca2+/calmodulin-dependent phosphorylation of adrenal cell cytoskeletal proteins is mediated by the cytoskeleton associated kinase II. 1989 ASCB annual meeting, Houston, TX, U.S.A., J. Cell Biology. 109:83.
48. Davis CM, V. Papadopoulos, H. Kleinman, Y. Yamada, P. Savagner, B. Clement and M. Dym (1989). The expression of laminin and laminin binding proteins in testis development. 1989 ASCSB annual meeting, Houston, TX., U.S.A., J. Cell Biology. 109:108.
49. Papadopoulos V, A.G. Mukhin, E. Costa and K.E. Krueger (1990). The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. American Society of Andrology, 1990 annual meeting, Columbia, South Carolina, U.S.A., J. Androl. 11:22.
50. Davis CM,V. Papadopoulos, H.K. Kleinman, Y. Yamada, and M. Dym (1990). Expression of extracellular matrix components during testis development. American Society of Andrology, 1990 annual meeting, Columbia, South Carolina, U.S.A., J. Androl. 11:30.
51. Krueger KE and V. Papadopoulos (1990). Mitochondrial benzodiazepine receptors mediate cholesterol transport to inner mitochondrial membranes. 74th annual FASEB meeting, Washington, D.C., April 1-5, U.S.A., The FASEB Journal, 4:3252.
52. Papadopoulos V, M-C. Jia, H.K. Kleinman, and M. Dym (1990). Extracellular matrix regulates G-protein levels and FSH responsiveness of Sertoli cell adenylyl cyclase activity in vitro. Endocrine Society annual meeting, Atlanta, Georgia, June 20-24, U.S.A., Abstract No. 432.
53. Dym M, M.A. Hadley, V. Papadopoulos, M-C. Jia, B.S. Weeks and H.K. Kleinman (1990). Laminin regulates Sertoli cell differentiation and cyclic AMP and G protein levels. Society for the Study of Reproduction annual meeting, Knoxville, Tennessee, July 15-18, U.S.A., Biology of Reproduction, 42 (suppl.1):160.
54. Dym M, H.K. Kleinman, and V. Papadopoulos (1990). Sertoli cell response to basement membrane-signal transduction events. IX International symposium on morphological sciences, Nancy, September 9-13, France.
55. Krueger KE, A.G. Mukhin, and V. Papadopoulos (1990). Coupling between mitochondrial benzodiazepine receptors and hormone stimulated steroidogenesis. Society for Neuroscience annual meeting, St. Louis, Missouri, October 28-November 2, U.S.A., 471.4.
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56. Krueger KE and V. Papadopoulos (1990). The peripheral-type benzodiazepine receptor: cell biological role and pharmacological significance. "Transmitter Amino Acid Receptors" Symposium, Royal Society Meeting, London, October 22-24, U.K., No. 14.
57. Papadopoulos V, A. Berkovich, and K.E. Krueger (1990). Role of DBI and its processing products at peripheral-type benzodiazepine receptors: stimulation of steroid biosynthesis. International meeting on Diazepam Binding Inhibitor, FIDIA-Georgetown Institute for the Neurosciences, Georgetown University, November 29-30, U.S.A., No. 13.
58. Onoda M, D. Djakiew, and V. Papadopoulos (1991). Germ cells regulate the secretion of Sertoli cell protein(s) which stimulate Leydig cell steroidogenesis. XIth North American Testis Workshop, Montreal, April 24-27, Canada, No. 34.
59. Papadopoulos V (1991). Hormone-stimulated steroidogenesis is coupled to mitochondrial benzodiazepine receptors. 5th World Congress of Biological Psychiatry, Florence, June 9-14, Italy.
60. Krueger KE and V. Papadopoulos (1991). Molecular and functional characterization of peripheral-type benzodiazepine receptors in glial cells. 5th World Congress of Biological Psychiatry, Florence, June 9-14, Italy.
61. Papadopoulos V, A. Berkovich, K.E. Krueger, E. Costa and A. Guidotti (1991). Diazepam Binding Inhibitor (DBI) and its processing products stimulate mitochondrial steroidogenesis. Endocrine Society annual meeting, Washington, D.C. June 19-22, U.S.A., No. 137.
62. Costa E, V. Papadopoulos and K.E. Krueger (1991). The mitochondrial benzodiazepine receptor (MBR): biochemistry and function. European College of Neuropharmacology annual meeting, Monaco, October, 6-9, Monte Carlo.
63. Papadopoulos V, P.F. Hall and A.S. Brown (1991). Hormonal stimulation of steroidogenesis does not effect endozepine/diazepam binding inhibitor levels in hormone sensitive adrenocortical and Leydig tumoral cell lines. Endocrine Society of Australia annual meeting, Sydney, September 29-October 2, Australia.
64. Whalin ME, V. Papadopoulos, E. Costa and K.E. Krueger (1991). Phosphorylation of mitochondrial benzodiazepine receptors. Society for Neuroscience 1991 annual meeting, New Orleans, Louisiana, November 10-15, U.S.A., pp.917.
65. Guarneri P, V. Papadopoulos, B. Pan and E. Costa (1991). Cholesterol and pregnenolone formation in intact glioma C6 cells: Regulation by mitochondrial benzodiazepine receptor ligands (MBR). Society for Neuroscience 1991 annual meeting, New Orleans, Louisiana, November 10-15, U.S.A., pp.916.
66. Romeo E, A.P. Kozikowski, D. Ma, V. Papadopoulos, J. Auta, A. Guidotti and E. Costa (1991). 2-Aryl-3-indoleacetamides (AIAM): A new class of potent and specific ligands for the mitochondrial benzodiazepine receptor (MBR). Society for Neuroscience 1991 annual meeting, New Orleans, Louisiana, November 10-15, U.S.A., pp.1341.
67. Papadopoulos V, P. Guarneri, K.E. Krueger, A. Guidotti and E. Costa (1991). The endogenous polypeptide DBI and other drug ligands of mitochondrial benzodiazepine receptors (MBR) stimulate steroidogenesis by C6-2B glioma cell mitochondria. Society
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for Neuroscience 1991 annual meeting, New Orleans, Louisiana, November 10-15, U.S.A., pp.1477.
68. Radhakrishnan B, B. Oke, V. Papadopoulos and C.A. Suarez-Quian (1992). Epidermal growth factor (EGF) and its receptor (EGFR) in mouse testis. American Society of Andrology, 1992 annual meeting, Washington, D.C., March 27-30, U.S.A., J. Androl. suppl. p.21.
69. Garnier M, A.S. Brown, B. Oke, C.A. Suarez-Quian and V. Papadopoulos (1992). Diazepam binding inhibitor: an autocrine/paracrine regulator of Leydig cell growth and steroid synthesis. Endocrine Society annual meeting, San Antonio, TX, June 24-27, U.S.A., No. 567.
70. Papadopoulos V, M-C. Jia, M. Culty and M. Dym (1993). Rat Sertoli cell aromatase cytochrome P450: regulation by cell culture conditions and relationship to the state of cell differentiation. XIIth North American Testis Workshop, Tampa FL, April 13-16, U.S.A., No. II.22.
71. Boujrad N, J.R. Hudson and V. Papadopoulos (1993). The polypeptide diazepam binding inhibitor mediates the hormonal stimulation of steroidogenesis. XIIth North American Testis Workshop, Tampa FL, April 13-16, U.S.A., No. I.11.
72. Garnier M, A.B. Dimchev, N. Boujrad, N.A. Musto and V. Papadopoulos (1993) Cloning, procaryotic expression and purification of the MA-10 mouse Leydig cell peripheral-type benzodiazepine receptor (PBR): evidence that the receptor is a multimeric complex. Endocrine Society annual meeting, Las Vegas, NV, June 9-13, U.S.A., No. 1219.
73. Boujrad N, J-L. Gaillard, J.R. Hudson and V. Papadopoulos (1993) Hormonal regulation of cholesterol transport, rate-determining step in steroidogenesis. Endocrine Society annual meeting, Las Vegas, NV, June 9-13, U.S.A., No. 981.
74. Guarneri P, R. Guarneri, C. Cascio, P. Pavasant, F. Piccoli and V. Papadopoulos (1993). Neurosteroids in rat retinas. Society for Neuroscience 1993 annual meeting, Washington, D.C., November 10-15, U.S.A., No. 567.14.
75. Guarneri P, Guarneri R, Cascio C, Piccoli F, Papadopoulos V (1993). Neurosteroidogenesis in rat retina. International Study Group for Steroid Hormones. XVI meeting, November 28- December 1, Vienna, Austria.
76. Dym M, Papadopoulos V (1993). Sertoli cell attachment and spreading on basement membrane is inhibited by antisense to c-fos. 1993 ASCSB annual meeting, New Orleans, La, U.S.A., J. Cell Biology, No. 2108.
77. Ravindranath N, Papadopoulos V, Vornberger W, Zitzmann D, Dym M (1993). Laminin-mediated Sertoli cell spreading. A possible role for calcium. 1993 ASCSB annual meeting, New Orleans, La, U.S.A., J. Cell Biology, No. 2109.
78. Boujrad N, Gaillard J-L, Garnier M, Papadopoulos V (1994) Identification of a hormone-induced higher affinity benzodiazepine binding site related to the induction of steroid synthesis. VIIIth European Testis Workshop, March 27-31, De Panne, Belgium.
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79. Garnier M, Boujrad N, Hudson JR and Papadopoulos V (1994) The polypeptide diazepam binding inhibitor and a higher affinity benzodiazepine receptor are responsible for constitutive steroidogenesis in R2C rat Leydig tumor cells. VIIIth European Testis Workshop, March 27-31, De Panne, Belgium.
80. Garnier M, Dimchev A, Boujrad N, Price JM, Musto NA and Papadopoulos V (1994) In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse tumor Leydig cells requires association with the voltage-dependent anion channel. VIIIth European Testis Workshop, March 27-31, De Panne, Belgium.
81. Boujrad N, Lee C-H, Garnier M and Papadopoulos V (1994) Purification and characterization of a Sertoli cell protein stimulating Leydig cell steroidogenesis. VIIIth European Testis Workshop, March 27-31, De Panne, Belgium.
82. Dirami G, Kleinman HK, Papadopoulos V and Dym M (1994) Extracellular matrix-induced potentiation of steroidogenic function in immature rat Leydig cells. VIIIth European Testis Workshop, March 27-31, De Panne, Belgium.
83. Dirami G, Kleiman HK, DeFreese D, Musto NA, Papadopoulos V and Dym M (1994) Transferrin, inhibin and ABP-like proteins are present in the extracellular matrix (Matrigel): fact or artifact? VIIIth European Testis Workshop, March 27-31, De Panne, Belgium.
84. Guarneri P, Guarneri R, Cascio C, Piccoli F and Papadopoulos V (1994) Neurosteroid synthesis in the retina is controlled by GABAA/benzodiazepine receptor complex. XIXth International College of Neuropharmacology, June 27-July 1, Washington, D.C., USA
85. Guarneri P, Guarneri R, Cascio C, Piccoli F and Papadopoulos V (1994) Metabotropic and ionotropic excitatory amino acid receptors regulate pregnenolone synthesis in the rat retina. XIXth International College of Neuropharmacology, June 27-July 1, Washington, D.C., USA
86. Ravindranath N, Jia M-C, Papadopoulos V and Dym M (1994) Developmental expression of the c-kit protooncogene in the rat testis. 27th annual meeting of the Society for the Study of Reproduction. July 24-27, Ann Arbor, MI., USA
87. Papadopoulos V and Boujrad N (1994) Intragonadal regulation of steroidogenesis: purification of a stimulatory protein complex. 27th annual meeting of the Society for the Study of Reproduction. July 24-27, Ann Arbor, MI., USA
88. Brown AS, Leydman M, Papadopoulos V (1994) Identification of an ACTH dependent, diazepam binding inhibitor (DBI) related 30Kd protein in bovine adrenocortical inner mitochondrial membranes. IX International Congress on Hormonal Steroids, September 24-29, Dallas, TX., USA
89. Boujrad N, Garnier M, Martin BM, and Papadopoulos V (1994) Tissue inhibitor of metalloproteinase I and pro-cathepsin L form a steroidogenesis stimulatory complex. 1994 Meeting of the American Society for Cell Biology, December 10-14, San Francisco, CA, USA
90. Boujrad N, Vidic B, and Papadopoulos V (1995) Hormone-induced changes in the sructure and topography of the mitochondrial peripheral benzodiazepine receptor.
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Proceedings of XIIth Testis Workshop: Cellular and Molecular Regulation of Testicular Cells, Serono Symposia, March 30- April 1, Raleigh, NC, USA
91. Papadopoulos V (1995) Growth factors, steroids and testicular function: a novel function for TIMP-1 and procathespin L. Conference on "Hormones and growth factors in development and neoplasia", Fogarty International Center, June 26-28, National Institutes of Health, Bethesda, MD, USA
92. Ogwuegbu SO, Boujrad N, Papadopoulos V (1995) Induction of the steroidogenesis stimulating protein complex by recombinant FSH in immature hypophysectomized rats: correlation with steroidogenesis and spermatogenesis. Endocrine Society Annual Meeting, June 14-17, Washington, D.C., USA
93. Vidic B, Obcemea CH, Nagahara L, Ikonomovic M, Boujrad N, Papadopoulos V (1995) An insight into the biophysical character and dynamics of suborganellar and molecular domains. XIIth International Symposium on Morphological Sciences, September 22-27, Thessaloniki, Greece.
94. Guarneri P, Guarneri R, Cascio C, Monastero R, Piccoli T, Papadopoulos V (1995) NMDA effects on retinal neurosteroids. Annual Meeting of the Society for Neurosciences, November 10-14, San Diego, CA, USA
95. Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H, Vidic B, Brown AS, Reversat JL, Bernassau JM, Drieu K (1996) Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. 2nd Intrnational Symposium on Molecular Steroidogenesis, June 7-11, Monterey, CA, USA
96. Vidic B, Boujrad N, Papadopoulos V (1996) Biophysical pathways of intracellular lipid processing in the MA-10 mouse Leydig cells stimulated by human choriogonadotropin. European Congress on Mocroscopy, August 26-30, Dublin, Ireland
97. Papadopoulos V (1996) Benzodiazepine receptors in steroidogenesis. 10th International Congress of Endocrinology, June 11-16, San Francisco, CA.
98. Boujrad N, Papadopoulos V (1996) Peripheral-type benzodiazepine receptor is a target of environmental hazards affecting testicular steroidogenesis. 10th International Congress of Endocrinology, June 11-16, San Francisco, CA, USA
99. Papadopoulos V, Boujrad N, Amri H, Vidic, Garnier M (1996) Targeted disruption of the peripheral-type benzodiazepine receptor gene in steroidogenic cells. 10th International Congress of Endocrinology, June 11-16, San Francisco, CA, USA
100. Amri H, Ogwuegbu SO, Drieu K, Papadopoulos V (1996) Reduction of adrenal PBR and glucocorticoid levels by the Ginkgo biloba extract EGb 761 and isolated ginkgolides. 10th International Congress of Endocrinology, June 11-16, San Francisco, CA, USA.
101. Boujrad N, Papadopoulos V (1996) Steroidogenesis stimulating complex in human follicular fluid. 10th International Congress of Endocrinology, June 11-16, San Francisco, CA, USA
102. Kragie L, Amri H, Flockhart, Papadopoulos V (1996) Cytochrome P450 aromatase: an in vitro screening tool for drug-steroid interactions. 10th International Congress of Endocrinology, June 11-16, San Francisco, CA, USA.
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103. Papadopoulos V (1996) Growth factors and Leydig cell function. 1st International Symposium of Biology and Pathology on Male Reproduction. June 20-22, Madrid, Spain.
104. Papadopoulos V (1996) Novel apsects of the regulation of Leydig cell function. 1st International Symposium of Biology and Pathology on Male Reproduction. June 20-22, Madrid, Spain.
105. Papadopoulos V, Amri H., Papadopoulos V (1996) Mechanisms underlying stress control. Effect of Ginkgo biloba extract EGb 761 and role of the peripheral benzodiazepine receptor. Advances in Ginkgo biloba Research, October 25-26, Ottrot, France.
106. Vidic B, Boujrad N, Papadopoulos V 1996 The role of Leydig cells in the metabolism of lipid-phospholipid moieties and steroidogenesis. II Congress on Electron Microscopy, October 2-5, Belgrand, Yugoslavia.
107. Hardwick M, Kozikowski AP, Papadopoulos V (1997) The peripheral-type benzodiazepine receptor in human breast cancer. American Association for Cancer Research, April 12-16, San Diego, CA, USA.
108. Vidic B, Boujrad N, Papadopoulos V (1997) Biophysical characterization of lipids in Leydig tumor cell acutely stimulated with human choriogonadotropin. Annual Meeting of the Anatomical Society. May 24-27, Olsztyn, (Annals of Anatomy, 170 suppl, p.46), Poland.
109. Li H, Papadopoulos V, Vidic B, Dym M, Culty M (1997) Regulation of rat testis gonocyte proliferation by PDGF and estradiol: identification of signaling mechanisms involved. XIVth Testis Workshop, Serono Symposia, Baltimore, MD, USA
110. Li H, Reversat JL, Bernassau JM, Papadopoulos V (1997) Peripheral benzodiazepine receptor (PBR) is a channel for cholesterol. Annual Meeting of the Endocrine Society, June 11-14, Minneapolis, MN,USA.
111. Amri H, Drieu K, Papadopoulos V (1997) Effect of the Ginkgo Biloba extract EGB 761 and isolated ginkgolide B on adrenal cortical cell steroid and protein synthesis in response to ACTH. Annual Meeting of the Endocrine Society, June 11-14, Minneapolis, MN, USA.
112. Cascio C, Prasad VVK, Lieberman S, Papadopoulos V (1997) Identification of a P450c17-independent pathway for dehydroepiandrosterone (DHEA) biosynthesis in brain glial tumor cells. Annual Meeting of the Endocrine Society, June 11-14, Minneapolis, MN, USA.
113. Sridaran R, Li H, Papadopoulos V (1997) GnRH agonist treatment decreases the luteal mRNA expression and ligand binding of the peripheral-type benzodiazepine receptor (PBR) during pregnancy. Society for the Study of Reproduction, Portland, OR, Biol. Reprod., 56(Suppl. 1):124, USA.
114. Brown RC, Cascio C, Kataoka H, Koono M, Papadopoulos V (1997) Evidence for neuroactive steroid synthesis in human brain glioma. Society for Neuroscience, October, New Orleans, LO, USA.
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115. Cascio C, Papadopoulos V (1997) Dehydroepiandrosterone and pregnenolone biosynthesis in the developing rat brain. Society for Neuroscience, October, New Orleans, LO, USA.
116. Papadopoulos V, Amri H, Drieu K (1997) Regulation of glucocorticoid synthesis by the Ginkgo biloba extract EGb 761 and isolated ginkgolides. II International Conference on Corticol and Anti-cortisols, November 9-12, Las Vegas, NV, USA.
117. Vanek PG, Bazar L, Papadopoulos V (1997) Development of an assay for DNA damage in situ (ADDIS). 37th Annual Meeting of the American Society for Cell Biology, December 13-17, Washington, D.C., USA; Mol Biol Cell Suppl. 8:1921.
118. Widmaier EP, Zilz A, Castello R, Li H, Papadopoulos V (1998) Coincident development of corticosteroidogenesis and mitochondrial peripheral-type benzodiazepine receptor expression in neonatal rat adrenals. Annual Meeting of the Endocrine Society, June 23-27, New Orleans, LA, USA.
119. Boujrad N, Papadopoulos V (1988) Peroxisome proliferators regulate the expression of the peripheral-type benzodiazepine receptor, cholesterol transport and steroidogenesis in Leydig tumor cells. Annual Meeting of the Endocrine Society, June 23-27, New Orleans, LA, USA
120. Papadopoulos V (1998) Mechanisms of cholesterol uptake and transport by mitochondria. Annual Meeting of the Endocrine Society, June 23-27, New Orleans, LA, USA
121. Hardwick M, Culty M, Vidic B, Papadopoulos V (1988) Peripheral-type benzodiazepine receptor in human breast cancer. International Congress on Hormonal Steroids, June 17-21, Quebec, CA, USA
122. Li H, Papadopoulos V (1998) Identification of peripheral-type benzodiazepine receptor associated proteins (PAPs) using the yeast two-hybrid system. International Congress on Hormonal Steroids, June 17-21, Quebec, CA, USA
123. Yao Z, Boujrad N, Drieu K, Papadopoulos V (1998) Protection of the Leydig cell cytochrome P450scc activity and steroidogenesis by ginkgolides. International Congress on Hormonal Steroids, June 17-21, Quebec, CA, USA
124. Papadopoulos V, Li H, Amri H, Boujrad N, Vidic M, Culty M (1998) Peripheral benzodiazepine receptor: a solo or a team player in steroidogenesis? International Congress on Hormonal Steroids, June 17-21, Quebec, CA, USA
125. Sridaran R, Philip GH, Li H, Culty M, Liu Z, Stocco DM, Papadopoulos V (1998) GnRH agonist treatment decreases progesterone synthesis, luteal peripheral benzodiazepine receptor mRNA, ligand binding, and steroidogenic acute regulatory protein expression during pregnancy. XIIth Ovarian Workshop, Houston, August 5-7, TX, USA
126. Brown RC, Papadopoulos V (1998) Neurosteroid biosynthesis in human astrocytes and neurons. Society for Neuroscience, November 7-12, Los Angeles, CA, USA
127. Vidic B, Lacapere JJ, Boujrad N, Papadopoulos V (1998) Effect of choriogonadotropine on the flux of phospholipid moiety in Leydig tumor cells: role of 18 kDa protein peripheral-type benzodiazepine receptor (PBR) in transporting phospholipids
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(cholesterol) across the outer mitochondrial membrane. 11th European Anatomical Congress, September 10-13, Timisoara, Romania
128. Brown RC, Cascio C, Papadopoulos V (1999) Pathways of neurosteroid biosynthesis in human brain: regulation by -amyloid protein. Annual Meeting of the Endocrine Society, June 11-15, San Diego, CA, USA
129. Papadopoulos V, AM Dharmarajan AM, Li H, Culty M, Lemay M, Sridaran R (1999)
The levels of the mitochondrial PBR correlate with the GnRH agonist-induced apoptosis in the corpus luteum. Annual Meeting of the Endocrine Society, June 11-15, San Diego, CA, USA
130. Hardwick M, Fertikh D, Culty M, Li H, Vidic B, Papadopoulos V (1999) Peripheral benzodiazepine receptor and cholesterol in human breast cancer. Folia Morphologica, 58 (suppl. 1). Congress of the Polish Anatomical Society and of the Polish Society of Histochemistry and Cytochemistry, June 25-29, Lotz, Poland
131. Vidic B, Lacapere JJ, Boujrad N, Papadopoulos V (1999) Metabolism and biophysical transformation of cytoplasmic phospholipid molecules in leydig tumor cell stimulated with human chorionic gonadotropin. Folia Morphologica, 58 (suppl. 1). Congress of the Polish Anatomical Society and of the Polish Society of Histochemistry and Cytochemistry, June 25-29, Lotz, Poland
132. Brown RC, Cascio C, Papadopoulos V (1999) Neurosteroid biosynthesis and regulation in human brain. 52nd Yamada Conference on Molecular Steroidogenesis. Yamada Science Foundation, August 25-28, Nara, Japan
133. Lindemann P, Koch A, Hause G, Papadopoulos V, Luckner M (1999) Evidence for a benzodiazepine binding protein in plants. 52nd Yamada Conference on Molecular Steroidogenesis. Yamada Science Foundation, August 25-28, Nara, Japan
134. Boujrad N, Papadopoulos V (1999) Peripheral-type benzodiazepine receptor is a target of environmental hazards affecting the hormonal regulation of testicular steroidogenesis. VIth International Symposium on Reproductive Biology of Fish, July 4-9, Bergen, Norway
135. Brown RC, Papadopoulos V (1999) The role of the peripheral-type benzodiazepine receptor in steroid biosynthesis and proliferation is determined by its subcellular localization. Society for Neuroscience, October 23-28, Miami Beach, Florida, USA
136. Vidic B, Lacapere JJ, Boujrad N, Papadopoulos V (1999) Peripheral-type benzodiazepine receptor (PBR): biophysical properties, topography and role of PBR in the intracellular transport of cholesterol. Italian J. Anatomy Embryology, 104 (suppl. 1):741, International Congress of Anatomy, September 15-20, Rome, Italy
137. Papadopoulos V (1999) PBR in cholesterol transport and steroidogenesis. Proceedings of the 18th meeting of the Society for Reproductive Biology & Comparative Endocrinology, Symposium on “Endocrine Update Towards Next Millenium”, Madras Christian College, December 27-29, Chennai, India
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138. Papadopoulos V (2000) Regulation of the peripheral-type benzodiazepine receptor expression and function. 14th Rappaport Symposium “The Molecular Biology of Neuropsychiatric Diseases”, April 11-13, 2000, Haifa, Israel
139. Li H, Degenhardt B, Papadopoulos V (2000) Inhibition of hormone stimulated steroidogenesis by transduction of HIV-TAT protein fused to the carboxy-terminal domain of the peripheral benzodiazepine receptor. Society for Study of Reproduction, annual meeting, July 15-18, Madison, WI, USA
140. Dees JD, Papadopoulos V (2000) Effects of mono-ethylhexyl phthalate on cellular ultrastructure and steroid synthesis in hCG stimulated MA-10 Leydig tumor cells. Endocrine Society, annual meeting, June 21-24, Toronto, ONT, Canada
141. Gazouli M, Papadopoulos V (2000) Transcriptional regulation of peripheral-type benzodiazepine receptor gene expression and hCG-stimulated steroidogenesis by peroxisome proliferators. Endocrine Society, annual meeting, June 21-24, Toronto, ONT, Canada
142. Li H, Degenhardt B, Tobin D, Tasken K, Papadopoulos V (2000) Novel element in the hormonal regulation of steroidogenesis. PAP7: A peripheral-type benzodiazepine receptor-associated and A kinase anchoring protein. Endocrine Society, annual meeting, June 21-24, Toronto, ONT, Canada
143. Yao Z, Drieu K, Papadopoulos V (2000) The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from -amyloid-induced cell death by inhibiting the formation of -amyloid-derived diffusible neurotoxic ligands. Neurobiol. Aging, 21:S169, VIIth International Conference on Alzheimer’s Disease and Related Disorders, World Alzheimer Congress 2000, July 9-13, Washington, DC, USA
144. Brown RC, Cascio C, Papadopoulos V (2000) Neurosteroids: oxidative stress-mediated dehydroepiandrosterone formation in Alzheimer’s disease pathology. Neurobiol. Aging, 21: S238, VIIth International Conference on Alzheimer’s Disease and Related Disorders, World Alzheimer Congress 2000, July 9-13, Washington, DC, USA
145. Sridaran R, Yang H, Bhat GK, Culty M, Papadopoulos V (2000) Suppression of luteal steroidogenesis by a GnRH agonist in vitro mediated via a decrease in luteal production of NO, PBR and/or an increase in PGF2. International Congress of Endocrinology, Sydney, Australia
146. Amri H, Pretner E, Dagenhardt B, Papadopoulos V, Kulawardena DV (2000) Inhibition of human prostate cancer cell proliferation by homeopathic dilutions of Sabal serrulate. ” Comprehensive Cancer Care Conference, June 7-12, Crystal City, Arlington, VA, USA
147. Brown RC, Papadopoulos V (2000) Region-specific increases in peripheral-type benzodiazepine receptor binding and neurosteroid formation in Alzheimer’s disease. Society for Neuroscience, November 7-12, New Orleans, La, USA
148. Amri H, Morin D, Papadopoulos V (2000) Regulation of mitochondrial steroid synthesis by molecules acting at the permeability transition pore. Tunis Med. 78:3, November 8-10, Tunis-Carthage, Tunisia
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149. Giatzakis C, Gazouli M, Papadopoulos V (2001) Inhibition of Leydig cell peripheral-type benzodiazepine receptor gene expression by peroxisome proliferators: Involvement of the AP1 transcription factor. Endocrine Society, annual meeting, June 21-24, Denver, Colorado, USA
150. Amri H, Drieu K, Papadopoulos V (2001) Transcriptional suppression of adrenal Cortical peripheral-type benzodiazepine receptor gene and inhibition of steroid synthesis by Ginkgolide B. Endocrine Society, annual meeting, June 21-24, Denver, Colorado, USA
151. Papadopoulos V (2001) The peripheral benzodiazepine receptor and cholesterol delivery. Endocrine Society, annual meeting, June 21-24, Denver, Colorado, USA
152. Amri H, Drieu K, Papadopoulos V (2002) Inhibition of glucocorticoid synthesis by Ginkgo biloba extract EGb 761 and isolated ginkgolides. International Scientific Conference on Complementary, Alternative and Integrative Medical Research, Harvard Medical School, April 12-14, Boston, MA, USA
153. Papadopoulos V, Brown RC (2002) Neurosteroid synthesis in neurodegeneration: an oxidative stress mediated process. 2002 World Congress on Oxidants and Antioxidants in Biology, March 6-9, Santa Barbara, CA, USA
154. Yao ZX, Papadopoulos V (2002) Function of ß-amyloid in cholesterol homeostasis: a lead to neurotoxicity. Endocrine Society, annual meeting, June 19-22, San Francisco, CA, USA
155. Hauet T, Yao ZX, Wall CT, Hales DB, Papadopoulos V (2002) Respective role of peripheral-benzodiazepine receptor (PBR) and steroidogenic acute regulatory protein (StAR) in trophic hormone-stimulated steroidogenesis. Endocrine Society, annual meeting, June 19-22, San Francisco, CA, USA
156. Liu J, Han Z, Sandrini F, Bei T, Matyakhina L, Stratakis CA, Papadopoulos V (2002) Cloning and localization of human peripheral-type benzodiazepine receptor- and protein kinase A (RI)-associated protein PAP7 and its investigation in Carney complex. Endocrine Society, annual meeting, June 19-22, San Francisco, CA, USA
157. Banerjee S, Thuillier R, Culty M, Papadopoulos V, Brown TR, Banerjee PP (2002) In utero exposure to di(2-ethylhexyl) phthalate (DEHP) alters growth, tissue organization and the expression of androgen receptor protein of rat prostate. Society for Study of Reproduction, Baltimore, MD, USA.
157. Han Z, Slack RS, Papadopoulos V (2002) Peripheral benzodiazepine receptor levels correlate with breast and other tumor progression and metastasis. Era of Hope 2002 Department of Defense Breast Cancer Research Program Meeting., Florida, USA.
158. Hauet T, Liu J, Li H, Papadopoulos V (2002) PBR, StAR and PKA: partners in cholesterol transport. Adrenal Cortex Conference 2002, San Francisco, CA, USA
159. Delavoie F, Giatzakis C, Li H, Robert JC, Yao ZX, Peranzi G, Vidic B, Papadopoulos V, Lacapere JJ (2002) Peripheral-type benzodiazepine receptor polymerization leads to drug ligand activated cholesterol transport. European Bioenergetic Congress, September 11-15, Arcanchon, France
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160. Marazova K, Peranzi G, Delavoie F, Ostuni M, Vidic B, Papadopoulos V, Ducroc R, Lacapere JJ (2002) Studies on the peripheral-type benzodiazepine receptor in rat stomach. Faculté de Médecine Xavier Bichat Research days, Paris, France
161. Papadopoulos V (2002) An unexpected effect of molecular biology: role of EGb 761 extract on the expression of genes involved in cell proliferation. A hope against cancer onsets or metastasis appearance. Ginkgo biloba Conference: from traditional medicine to a medicine of the future, October 11-13, Berlin, Germany
162. Yao Z, Brown RC, Teper G, Greeson J, Papadopoulos V (2002) 22R-hydroxycholesterol protects neuronal cells from ß-amyloid-induced cytotoxicity by binding to ß-amyloid peptide. Therapeutic Opportunities in Neurodegenerative Diseases, Cold Spring Harbor Laboratory meetings, December 5-8, Cold Spring Harbor, NY, USA.
163. Lecanu L, Yao W, Teper G, Yao ZX, Greeson J, Papadopoulos V (2002) Naturally occurring 22R-hydroxycholesterol steroid derivatives protect neuronal cells against -amyloid (1-42) toxicity. Therapeutic Opportunities in Neurodegenerative Diseases, Cold Spring Harbor Laboratory meetings, December 5-8, Cold Spring Harbor, NY, USA.
164. Heydens WF, Levine SL, Farmer DR, Han Z, Wall CT, Papadopoulos V (2003) Non-specific alteration of steroidogenesis in MA-10 Leydig cells by supra-physiological concentrations of the surfactant in Roundup herbicide. Society of Toxicology, March 9-13, Salt Lake City, Utah, USA; Tox Sci Suppl. 72:637
165. Li W, Amri H, Wu C, Papadopoulos V (2003) Protein and gene profiling of the MA-10 Leydig tumor cell acute response to human choriogonadotropin. North American Testis Workshop, March 26-29, Phoenix, AZ, USA
166. Culty M, Thuillier R, Li W, Wang Y, Triantafilou K, Papadopoulos V (2003) Prenatal exposure to di-(2-ethylhexyl) phthalate alters gene expression in developing testis. North American Testis Workshop, March 26-29, Phoenix, AZ, USA
167. Xu J, Lecanu L, Yao Z-X, Han Z, Greeson J, Papadopoulos V (2003) Inhibition of HMG-CoA reductase enzyme activity and cAMP-stimulated steroid formation in adrenal cells by procaine based compounds. Endocrine Society, annual meeting, June 18-21, Philadelphia, PA, USA
168. Stokes A, Barnhill J, Huberson M, Shimoda L, Papadopoulos V, Turner H (2003) A novel A-kinase adapter protein mediates complex formation between protein kinase A and TRPV ion channels. Biophysical Society annual meeting, San Antonio, TX, USA, Biophysical J 84:551A-552A
169. Marshall J, Zakari A, Hwang JJ, Papadopoulos V, Rosenberg A, Silver C (2004) Ginkgo biloba (GB) extract as a neuroprotective agent in Oxliplatin (Ox)-induced neuropathy. Abstract No. 3670. American Society of Clinical Oncology annual meeting, June 5-8, New Orleans, LA, USA, Journal of Clinical Oncology, 22(14S):3670.
170. Ostuni MA, Peranzi G, Ducroc R, Papadopoulos V, Lacapere JJ (2004) Characterization of peripheral benzodiazepine receptor in rat intestine. CECED (club d’etude des cellular epitheliales digestives), April 3-27, Paris, France
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171. Barlow KD, Papadopoulos V (2004) Transcriptional regulation of the peripheral-type benzodiazepine receptor in MDA-MB-2312 cells. American Association for Cancer Research Annual meeting, March 27-31, Orlando, Florida, USA, Proceedings AACR, 45:220
172. McCourty A, Greeson J, Papadopoulos V, Lecanu L (2004) Effect of a novel acetylcholinesterase inhibitor, dimethyl-carbamic acid 2,3-bis-dimethylcarbamoyloxy-6-[4-(4-ethyl-piperazin-1-yl)-butyryl]-phenyl ester, in vitro and ex vivo, on rat brain acetylcholinesterase activity. Biotechnology Days, Georgetown University, May 13, Washington, DC, USA
173. Hauet T, Yao Z, Bose HS Wall CT, Han H, Hales DB, Miller WL, Culty M, Papadopoulos V 2004 Functional interaction of PBR and StAR in cholesterol transport and steroidogenesis. Adrenal Cortex Conference 2004, New Orleans, LA, USA
174. Papadopoulos V, Yao Z, Liu Y 2004 Cytochrome P450 17α Hydroxylase/17,20 Lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells. Abstract No. 328. Society for Study of Reproduction 37th Annual Meeting, August 1-4, Vancouver, British Columbia, Canada; Biol Reprod 71 (suppl 1):168
175. Liu Y, Yao Z, Bendavid C, Borgmeyer C, Han Z, Cavalli LR, Chan WY, Folmer J, Zirkin BR, Haddad BR, Gallicano GI, Papadopoulos V 2004 Cytochrome P450 17α-hydroxylase/17,20 lyase (CYP17) gene deletion causes infertility in mice. Abstract No. 697. Society for Study of Reproduction 37th Annual Meeting, August 1-4, Vancouver, British Columbia, Canada; Biol Reprod 71 (suppl 1):253
176. Brown SJ, Lecanu L, Fareed G, Codina S, Azen SP, Yao W, Greeson J, Papadopoulos V 2004 Procaine hydrochloride: in vitro antiretroviral properties and reduction of viral load in HAART-resistant patients. 2004 International Meeting of the Institute of Human Virology, October 31-November 4, Baltimore, MD, USA
177. Xu J, Lecanu L, Tan M, Yao W, Greeson J, Papadopoulos V 2004 The Mechanism of Inhibition of HIV entry in MAGI cells by the procaine based benzamide derivative SP-10. 2004 International Meeting of the Institute of Human Virology, October 31-November 4, Baltimore, MD, USA
178. Lecanu L, Yao W, Piechot A, Greeson J, Tzalis D, Papadopoulos V 2004 Synthesis and characterization of the quinuclidine derivative SP-03 with antiretroviral properties. 2004 International Meeting of the Institute of Human Virology, October 31-November 4, Baltimore, MD, USA
179. Tillement L, Lecanu L, Greeson J, Papadopoulos V (2004) The spirostenol (22S,25S)-(20S)-spirost-5-en-3-yl hexanoate blocks mitochondrial Aβ uptake in neuronal cells and prevents Aβ -induced mitochondrial function impairment. Therapeutic Opportunities in Neurodegenerative Diseases, Cold Spring Harbor Laboratory meetings, December 2-5, Cold Spring Harbor, NY, USA.
180. Lecanu L, McCourty L, Tillement L, Yao W, Piechot A, Greeeson J, Tzalis D, Papadopoulos V (2004) Synthesis and characterization of dimethyl-carbamic acid 2,3-bis-dimethylcarbamoyloxy-6-[4-(4-ethyl-piperazin-1-yl)-butyryl]-phenyl ester, a dual
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inhibitor of AchE and 1 ligand with neuroprotective properties against Aβ1-42. Therapeutic Opportunities in Neurodegenerative Diseases, Cold Spring Harbor Laboratory meetings, December 2-5, Cold Spring Harbor, NY, USA.
181. Barlow KD, Papadopoulos V (2005) A downstream element differentially regulates the core promoter of the peripheral-type benzodiazepine receptor gene in MCF-7, MDA-MB-231 and MA-10 cells. AACR April 16-20, Los Angeles, CA, USA
182. Levine SL, Han Z, Liu J, Farmer DR, Papadopoulos V (2005) Mitochondrial mediated effects of surfactants on MA-10 cell steroidogenesis. North American Testis Workshop, March 28-April 2, Seattle, WA, USA
183. Hauet T, Yao Z, Bose, S, Wall CT, Han Z, Hales, BD, Miller WL, Culty M, Papadopoulos V (2005) Peripheral-type benzodiazepine receptor (PBR)-mediated action of steroidogenic acute regulatory (StAR) protein on cholesterol entry into Leydig cell mitochondria. . North American Testis Workshop, March 28-April 2, Seattle, WA, USA
184. Liu J, Papadopoulos V (2005) Hormone-dependent formation of a mitochondrial cAMP signaling complex that mediates the acute effect of cAMP in steroidogenesis. Endocrine Society, 87th annual meeting, June 4-8, San Diego, CA, USA
185. Giatzakis C, Papadopoulos V (2005) Intact Sites for ETS, AP1 and SP1/SP3 Transcription Factors are Required for Maximal Activity of the Mouse Peripheral-type Benzodiazepine Receptor Promoter in MA-10 and NIH/3T3 cells. Endocrine Society, 87th annual meeting, June 4-8, San Diego, CA, USA
186. Liu Y, Yao Z, Bendavid C, Borgmeyer C, Han Z, Cavalli LR, Chan W-Y, Folmer J, Zirkin BR, Haddad BR, Gallicano GI, Papadopoulos V (2005) Haploinsufficiency of cytochrome P450 17α-hydroxylase/17,20 lyase (CYP17) causes infertility in male mice. Vth International Conference on Reproductive Endocrinology, September 9-12, Beijing, P.R. China
187. Culty M, Thuillier R, Li W, Wang Y, Zirkin BR, Papadopoulos V (2005). Short and long term effects of prenatal exposure to di-(2-ethylhexyl) phthalate on rat Leydig cells. NIEHS Fetal Basis of Adult Disease meeting, November 1, Research Triangle Park, NC, USA
188. Amri H, Degenhardt B, Pretner E, Kulawardane D, MacLaughlin B, Papadopoulos V (2006). Effects of homeopathic saw palmetto (Sabal Serrulata) on human prostate cancer cells. North American Research Conference on Complementary Alternative Medicine, May 24-27, Edmonton, Canada
189. Amri H, Pretner E, Li W, Brown R, Lin C-H, Makariou E, DeFeudis FV, Drieu K, Papadopoulos V (2006). Effects of Ginkgo biloba extract EGb 761 on tumor growth and metastasis: an adjuvant therapeutic alternative? North American Research Conference on Complementary Alternative Medicine, May 24-27, Edmonton, Canada
190. Lecanu L, Ibrahim A, Yao W, Greeson J, Papadopoulos V (2005) A steroid naturally occurring in the soft water fungi Achlya Heterosexualis induces neurogenesis in vitro and in vivo in rat brain. Society for Neurosciences Annual meeting, November 17-22, Washington, DC, USA
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191. Batarseh AM, Giatzakis C, Papadopoulos V (2005) Phorbol-12-myristate-13-acetatte enhances peripheral-type benzodiazepine receptor promoter activity in mouse kidney COS7 cells. Georgetown University Research Days, Washington, DC, USA
192. Ruksha TG, Papadopoulos V (2006) Structural alterations of peripheral benzodiazepine receptor induced by UVB light in melanoma cells. 20th IUBMB Congress of Biochemistry and Molecular Biology, June 18-23, Kyoto, Japan
193. Li W, Barlow K, Papadopoulos V (2006) Ginkgo Biloba Extract in the Treatment of Human Breast Cancer The Suzan G. Komen Breast Cancer Foundation 2006 Mission Conference: Many Faces-One Voice. June 11-13, Washington, DC, USA
194. Papadopoulos V, Rone MB, Liu J (2006) Formation of a mitochondrial signaling complex mediates the acute effect of cAMP in steroidogenesis. Adrenal Molecular Steroidogenesis Meeting, June 20-23, Courtyard Boston Tremont Hotel, Boston, MA, USA
195. Rone MB, Papadopoulos V (2006) Targeting of the cholesterol translocator protein peripheral-type benzodiazepine receptor to the outer mitochondrial membrane. Endocrine Society, 88th annual meeting, June 24-27, Boston, MA, USA
196. Culty M, Thuillier R, Li W, Wang Y, Zirkin BR, Papadopoulos V (2006). Short and long term effects of prenatal exposure to di-(2-ethylhexyl) phthalate on rat Leydig cells. Endocrine Society, 88th annual meeting, June 24-27, Boston, MA, USA
197. Bai M, Bornhop DJ, Han Z, Rone M, Papadopoulos V (2006) A Novel Functional Peripheral Benzodiazepine Receptor Ligand for Enhanced Cancer Imaging and Therapy. Annual Meeting of Society of Molecular Imaging, August 30 - September 2, Big Island of Hawaii, Hawai, USA
198. Lecanu L, Tillement L, McCourty A, Yao W, Lowe J, Piechot A, Greeson J, Tzalis D, Papadopoulos V (2006) Synthesis and biological evaluation of dimethyl-carbamic acid 2,3-bis-dimethylcarbamoyloxy-6-(4-ethyl-piperazine-1-carbonyl)-phenyl ester: a multi-target therapeutic approach to neuroprotection. Society for Neurosciences, 36th annual meeting, October 14-18, Atlanta, GA, USA
199. Lecanu L, Ibrahim A, Yao W, McCourty A, Greeson J, Papadopoulos V (2007) In vitro and in vivo Induced Neurogenesis by the naturally occurring steroid solasodine is associated with GAP-43/HuD pathway activation and increase of the Translocator Protein (18 kDa) (TSPO) expression. IV International Meeting on Steroids and the Nervous System, February 17-21, Villa Gualino, Turin, Italy
200. Chalbot S, Lecanu L, Greeson J, Papadopoulos V (2007) Oxidation-dependent plasma DHEA formation as a diagnostic tool for Alzheimer’s disease pathology: results from a trial. IV International Meeting on Steroids and the Nervous System, February 17-21, Villa Gualino, Turin, Italy
201. Ostuni MA, Peranzi G, Tumilasci OR, Papadopoulos V, Lacapere J-J (2007) PK 11195, specific ligand of TSPO, potentiates the action of sialagogues in rat submandibular glands. CECED (club d’etude des cellular epitheliales digestives), March 19-21, Lyon, France
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202. Lecanu L, Sidahmed E-K, Greeson J, Papadopoulos V (2007) Caprospinol improves brain histopathology and recovers memory function in a rat model of Alzheimer’s disease. 8th International Conference Alzheimer’s Disease/Parkinson’s Disease, March 14-18, Salzburg, Austria.
203. Rone MB, Liu J, Blonder J, Veenstra TD, Papadopoulos V (2007) Targeting and insertion of the cholesterol-binding Translocator Protein into the outer mitochondrial membrane. American Society of Biochemistry & Molecular Biology Annual Meeting, April 28-May 2, Washington, DC, USA
204. Liu J, Rone MB, Papadopoulos V (2007) PAP7 is a steroidogenesis signal transporter from Golgi apparatus to mitochondria in mouse MA-10 Leydig cells. American Society of Biochemistry & Molecular Biology Annual Meeting, April 28-May 2, Washington, DC, USA
205. Ruksha TG, Papadopoulos V (2007) Structural alterations of peripheral benzodiazepine receptor induced by UVB light in melanoma cells. 16th Congress of European Academy of Dermatology & Venereology, 16-20 May, Vienna, Austria
206. Rone M, Liu J, Blonder J, Veenstra T, Papadopoulos V (2008) A two-step process in targeting and insertion of the cholesterol-binding Translocator Protein (18-kDa) into the outer mitochondrial membrane. Endocrine Society, annual meeting, June 14-18, San Francisco, CA, USA
207. Sakai M, Ferraz de Paula V, Pinheiro ML, Ribeiro A, Rone MB, Martinez-Arguelles DB, Dagli MLZ, Papadopoulos V, Palermo-Neto J (2008) Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo. VII International Society for NeuroImmunomodulation Congress, April 24-27, Rio de Janeiro, Brazil
208. Ruksha T, Papadopoulos V (2008) Steroidogenesis-related protein expression is decreased in skin cancer. J. Investigative Dermatology 128:S30. International Investigative Dermatology Meeting (IID2008), May 14-17, Kyoto, Japan
209. Lecanu L, McCourty A, Sidahmed E-K, Papadopoulos V (2008) The neurosteroid derivative caprospinol reduces amyloid deposits and restores cognitive function in a rat model of Alzheimer’s disease. 13th International Congress on Hormonal Steroids and Hormones & Cancer, September 27-30th, 2008, Quebec City, Canada
210. Tillement L, Lecanu L, Papadopoulos V (2008) The neurosteroid derivative caprospinol protects mitochondrial function and neuronal cells from β-amyloid toxicity. 13th International Congress on Hormonal Steroids and Hormones & Cancer, September 27-30th, 2008, Quebec City, Canada
211. Liu Y, Pocivavsek A, Papadopoulos V (2008) Dehydroepiandrosterone formation is independent of cytochrome P450 17α-hydroxylase/17, 20 lyase activity in the mouse brain. 13th International Congress on Hormonal Steroids and Hormones & Cancer, September 27-30th, 2008, Quebec City, Canada
212. Batarseh A, Giatzakis C, Papadopoulos V (2008) Phorbol-12-myristate 13-acetate acting through protein kinase Cε induces translocator protein (18-kDa) Tspo gene expression.
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13th International Congress on Hormonal Steroids and Hormones & Cancer, September 27-30th, 2008, Quebec City, Canada
213. Rammouz G, Papadopoulos V, Lecanu L (2008) The neuroprotective steroid caprospinol crosses the blood brain barrier; analysis by liquid chromatography and tandem mass spectrometry. Congress on Hormonal Steroids and Hormones & Cancer, September 27-30th, 2008, Quebec City, Canada
214. Martinez-Arguelles DB, Culty M, Papadopoulos V (2008) Di-(2-ethylhexyl)-phthalate (DEHP) targets mineralocorticoid receptor through possible epigenetic mechanism. Congress on Hormonal Steroids and Hormones & Cancer, September 27-30th, 2008, Quebec City, Canada
215. Papadopoulos V, Rone MB (2008) Protein-protein interactions driving cholesterol transport in steroidogenic cell mitochondria. Cellular Lipid Transport: Connecting Fundamental Membrane Assembly Processes to Human Disease, American Society of Biochemistry and Molecular Biology Meeting. Oct 29-Nov 2, 2008 Cranmore Conference Center, Alberta, Canada
216. Papadopoulos V, Lecanu L (2008) Neurosteroids in the treatment of neurodegeneration. EHRLICH II, 2nd World Conference on Magic Bullets, October 3-5, Nurnberg, Germany
217. Martinez-Arguelles DB, Culty M, Papadopoulos V (2008) Di-(2-ethylhexyl)-phthalate (DEHP) targets mineralocorticoid receptor through possible epigenetic mechanism. 1st Annual Symposium of the “Reseau Quebecois en Reproduction”, November 17-18, Montreal, Canada
218. Batarseh A, Giatzakis C, Papadopoulos V (2008) Phorbol-12-myristate 13-acetate acting through protein kinase Cε induces translocator protein (18-kDa) Tspo gene expression. 1st Annual Symposium of the “Reseau Quebecois en Reproduction”, November 17-18, Montreal, Canada
219. Chapalain A, Chevalier S, Papadopoulos V, Lesouhaitier O, Orange N, Feuilloley MGJ (2008) Physiological role of a prokaryotic peripheral-type benzodiazepine receptor–like system. Society for General Microbiology. Regulatory mechanisms in host-pathogen interactions. March 27-28, Galway, Eire
220. Chapalain A, Chevalier S, Papadopoulos V, Lesouhaitier O, Orange N (2008) Regulation of Pseudomonas virulence and surface interactions by eukaryotic communication messengers. Regulatory mechanisms in host-pathogen interactions. SGM Irish Branch, March 27-28, Galway, Eire
221. Chapalain A, Chevalier S, Dagorn A, Poc C, Orange N, Papadopoulos V, Feuilloley MGJ (2009) Eukaryotic benzodiazepine receptors ligands are sensed by Pseudomonas. 3rd
Congress of European Microbiologists. June 28-July 2, Goteborg, Sweden
222. Papadopoulos V, Rammouz G, Greeson J, Lecanu L (2009) Oxidative stress-mediated DHEA formation in patients’ serum: the biochemical basis for a diagnosis of Alzheimer’s disease. “Alzheimer’s and Parkinson’s Diseases: Advances, Concepts and New Challenges”, 9th International Conference for AD/PD, March 11-15, Prague, Czech Republic
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223. Fan J, Rone M, Papadopoulos V (2009) Translocator protein 2 (TSPO2), a new family of proteins involved in cholesterol redistribution in erythropoiesis. American Society of Biochemistry & Molecular Biology Annual Meeting, April 18-22, New Orleans, LA, USA
224. Rone MB, Papadopoulos V (2009) Regulation of steroidogenesis in MA-10 mouse Leydig cells by autophagy. Endocrine Society, 91st annual meeting, June 10-13, Washington, DC, USA
225. Li J, Papadopoulos V (2009) Can adipocytes synthesize steroids de novo? 2nd Annual Symposium of the “Reseau Quebecois en Reproduction”, November 17-18, Montreal, Canada
226. Martinez–Arguelles DB, Culty M, Zirkin BR, Papadopoulos V (2009) In utero exposure to di-(2-ethylhexyl) phthalate decreases adrenal aldosterone production and reduces testicular androgen formation in the adult. 2nd Annual Symposium of the “Reseau Quebecois en Reproduction”, November 17-18, Montreal, Canada
227. Martinez–Arguelles DB, Culty M, Zirkin BR, Papadopoulos V (2010) In utero exposure to di-(2-ethylhexyl) phthalate targets the angiotensin receptors and reduces aldosterone production in the adrenal leading to reduced testicular androgen formation in the adult. American Society of Andrology Annual Meeting, April 10-13, Houston, TX, USA
228. Martinez–Arguelles DB, Culty M, Zirkin BR, Papadopoulos V (2010) In Utero exposure to di-(2-ethylhexyl) phthalate affects the adrenal potassium channel expression leading to reduced circulating aldosterone levels in the adult. XIV Adrenal Cortex Conference, June 16-18, San Diego, CA, USA
229. Martinez–Arguelles DB, Culty M, Zirkin BR, Papadopoulos V (2010) In Utero exposure to di-(2-ethylhexyl) phthalate affects the adrenal potassium channel expression leading to reduced circulating aldosterone levels in the adult. Endocrine Society, 92nd annual meeting, June 19-22, San Diego, CA, USA
230. Batarseh A, Li J, Papadopoulos V (2010) Regulation of Translocator Protein 18-kDa (Tspo) gene expression through a protein kinase Cε (PKCε)-MAPK signal transduction pathway targeting STAT3 and c-Jun. Endocrine Society, 92nd annual meeting, June 19-22, San Diego, CA, USA
231. Rone M, Rammouz R, Blonder J, Prieto DA, Veenstra TD, Papadopoulos V (2010) Identification of hormone-induced bioactive mitochondrial protein complexes in MA-10 Leydig cells. Endocrine Society, 92nd annual meeting, June 19-22, San Diego, CA, USA
232. Midzak A, Akula N, Lecanu L, Papadopoulos V (2010) Identification of Novel Ligands Targeted to the Cholesterol Recognition / Interaction Amino Acid Consensus (CRAC) Domain of the Translocator Protein (TSPO). Endocrine Society, 92nd annual meeting, June 19-22, San Diego, CA, USA
233. Martinez–Arguelles DB, Culty M, Zirkin BR, Papadopoulos V (2010) In utero exposure to di(-ethylhexyl) phthalate disrupts adrenal-testis homeostasis leading to reduced aldosterone and androgen formation in the adult rat. International Congress of Pathophysiology, ISP2010, June 27-30, Montreal, Canada
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234. Batarseh A, Li J, Papadopoulos V (2010) Regulation of Translocator Protein 18-kDa (Tspo) gene expression through a protein kinase Cε (PKCε)-MAPK signal transduction pathway targeting STAT3 and c-Jun. 3rd Annual Symposium of the “Reseau Quebecois en Reproduction”, November 16-17, Quebec City, Canada
235. Martinez–Arguelles DB, Culty M, Zirkin BR, Papadopoulos V (2010) In Utero exposure to di-(2-ethylhexyl) phthalate targets the adrenal gland expression of the regulators of mineralocorticoid synthesis resulting in reduced circulating aldosterone synthesis in the adult. 3rd Annual Symposium of the “Reseau Quebecois en Reproduction”, November 16-17, Quebec City, Canada
236. Midzak A, Akula N, Lecanu L, Papadopoulos V (2010) Controlling leydig cell steroidogenesis with an androstenetriol interacting with the mitochondrial Translocator Protein (TSPO). 3rd Annual Symposium of the “Reseau Quebecois en Reproduction”, November 16-17, Quebec City, Canada
237. Rone M, Midzak A, Martinez–Arguelles DB, Rammouz R, Blonder J, Ye X, Veenstra TD, Papadopoulos V (2010) Identification of hormone-induced bioactive mitochondrial protein complexes in MA-10 Leydig cells. 3rd Annual Symposium of the “Reseau Quebecois en Reproduction”, November 16-17, Quebec City, Canada
238. Chapalain A, Dagorn A, Chevalier S, Murillo L, Orange N, Papadopoulos V, Feuilloley MGJ (2010) TSPO : Une protéine senseur structuralement et fonctionnellement conservée des mammifères aux bactéries. VIIIème Congrès de la SFM, June 2, Marseille, France
239. Fan J, Papadopoulos V (2010) Micro-transcriptional regulation of Translocator protein (TSPO) via a SINE B2-mediated natural antisense transcript. 3rd Annual Symposium of the “Reseau Quebecois en Reproduction”, November 16-17, Quebec City, Canada
240. Jagannathan SS, Fan J, Papadopoulos V (2010) Visualization of the dynamic formation of a mitochondrial cholesterol transport complex by Forster transfer energy transfer confocal microscopy. BioConnect Biotechnology Symposium, Montreal, Canada
241. Fan J, Martinez-Arguelles DB, Papadopoulos V (2011) Genome-wide expression of SINE B2-mediated natural antisense transcripts. Experimental Biology 2011, American Society for Biochemistry and Molecular Biology, April 9-13, Washington DC, USA FASEB J 25:512.1
242. Fan J, Papadopoulos V (2011) Micro-Transcriptional Regulation of Translocator Protein (Tspo) via a SINE B2-Mediated Natural Antisense Transcript. XXXI North American Testis Workshop, April 3-8, Montreal, Quebec, Canada
243. Rone M, Midzak A, Rammouz G, Martinez-Arguelles DM, Blonder J, Veenstra T, Papadopoulos V (2011) Mechanism of mitochondrial cholesterol transport by the steroidogenic acute regulatory protein. XXI North American Testis Workshop, "Testicular Determinants of Reproductive Success" March 30 - April 2, 2011, Montreal, Quebec, Canada
244. Aghazadeh Y, Rone M, Blonder J, Veenstra T, Papadopoulos V (2011) 14-3-3 adaptor proteins regulate the hormonal stimulation of steroidogenesis in MA-10 Leydig cells.
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XXI North American Testis Workshop, "Testicular Determinants of Reproductive Success" March 30 - April 2, 2011, Montreal, Quebec, Canada
245. Jagannathan SS, Fan J, Papadopoulos V (2011) Visualization of the dynamic formation of a mitochondrial cholesterol transport complex by Förster resonance energy transfer confocal microscopy. XXI North American Testis Workshop, "Testicular Determinants of Reproductive Success" March 30 - April 2, 2011, Montreal, Quebec, Canada
246. Midzak A, Papadopoulos V (2011) Structure-function analysis of a family of androstenetriols controlling Leydig cell steroidogenesis. XXI North American Testis Workshop, "Testicular Determinants of Reproductive Success" March 30 - April 2, 2011, Montreal, Quebec, Canada
247. Stanley E, Johnston D, Ge R, Fan R, Chen H, Papadopoulos V, Zirkin B, Jelinsky S (2011) Stem Leydig cell differentiation: gene expression during development of the adult population of Leydig cells. XXI North American Testis Workshop, "Testicular Determinants of Reproductive Success" March 30 - April 2, 2011, Montreal, Quebec, Canada
248. Chung J-Y, Papadopoulos V, Zirkin BR (2011) Ligand-induced activation of Translocator protein TSPO induces cholesterol transport and steroidogenesis in aged Leydig cells. 44th Annual Meeting of the Society for the Study of Reproduction July 31 -August 4, Portland, Oregon, USA
249. Li J, Papadopoulos V (2011) Steroid formation in adipocytes: biosynthesis and function. Endocrine Society, 93nd annual meeting, June 4-7, Boston, MA, USA
250. Pirangute RV, Midzak A, Papadopoulos V (2011) Targeting cholesterol recognition domain in translocator protein (18-kDa)-mediated cancer cell growth. Bio-Connect Annual Biotechnology meeting, Montreal, Quebec, Canada
251. Madriaga J, Midzak A, Rone M, Zirkin BR, Papadopoulos V (2011) Generating a steroidogenic model as a tool for investigating age-related deficits in men. Bio-Connect Annual Biotechnology meeting, Montreal, Quebec, Canada
252. Aghazadeh Y, Rone M, Blonder J, Veenstra TD, Hales DB, Papadopoulos V (2011) 14-3-3 Gamma regulates the Steroidogenic Acute Regulatory Protein (STAR) and steroidogenesis in hormone-induced MA-10 Leydig cells. Annual Symposium of the “Reseau Quebecois en Reproduction”, November 14-16, Montreal, Quebec, Canada
253. Smirle J, Rone M, Au C, Fernandez-Rodriguez J, Papadopoulos V, Nilsson T, Bergeron J (2012) Disruption of the tubular endoplasmic reticulum through atlastin-3 affects steroidogenesis in Leydig cells. MMSDG meeting, Montreal, QC, Canada
254. Rone M, Papadopoulos V (2012) Luteinizing hormone receptor signaling in MA-10 mouse Leydig cells. Endocrine Society Annual meeting, June 23-26, Houston, TX, USA
255. Midzak A, Pirangute R, Papadopoulos V (2012) The cholesterol recognition amino acid concensus (CRAC) motif of the 18-kDa Translocator protein (TSPO) as a chemotherapeutic target. Endocrine Society Annual meeting, June 23-26, Houston, TX, USA
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256. Aghazadeh Y, Rone MB, Blonder J, Ye X, Veenstra TD, Hales DB, Culty M, Papadopoulos V (2012) Hormone-induced 14-3-3γ adaptor protein regulates steroidogenic acute regulatory protein activity and steroid biosynthesis in MA-10 Leydig cells. Endocrine Society Annual meeting, June 23-26, Houston, TX, USA
257. Sakai M, Martinez-Arguelles D, Papadopoulos V (2012) In search of de novo steroid biosynthesis in human prostate cell lines and biopsies. McGill Endocrine retreat. Montreal, QC, Canada
258. Campioli E, Papadopoulos V (2012) Role of peroxisome proliferator activated receptors (PPARs) and translocator protein 18-kDa (TSPO 18-kDa) in the human preadipocytes differentiation. McGill Endocrine retreat. Montreal, QC, Canada
259. Fan J, Martinez-Arguelles DB, Papadopoulos V (2012) The role of Tspo-SINE B2 antisense in SINE B2 RNA toxicity revealed by genome wide expression profiling via next-generation sequencing. McGill Endocrine retreat & Center for the Study or Reproduction (CSR) annual meeting. Montreal, QC, Canada
260. Midzak A, Pirangute R, Papadopoulos V (2012) The cholesterol recognition amino acid concensus (CRAC) motif of the 18-kDa Translocator protein (TSPO) as a chemotherapeutic target. McGill Endocrine retreat & Center for the Study or Reproduction (CSR) annual meeting. Montreal, QC, Canada
261. Rone M, Papadopoulos V (2012) Endosomal signaling of the Luteinizing hormone receptor in MA-10 mouse Leydig cells. McGill Endocrine retreat & Center for the Study or Reproduction (CSR) annual meeting. Montreal, QC, Canada
262. Gunosewoyo H, Gaisina I, Hanania T, Thiede L, Fedolak A, Brunner D, Midzak A, Papadopoulos V, Kozikowski AP (2012) Targeting glycogen synthase kinase-3: an integrated approach to bipolar disorder therapy. Society for Neuroscience. Oct. 13-17, 2012, New Orleans, LA, USA
263. Boisvert A, Papadopoulos V, Culty M (2012) Use of reproductive safety criteria in the development of new plasticizers. Environmental Endocrine Disruptors, Gordon Research Conference, June 3-8, Mount Snow Resort, West Dover, VT, USA
264. Li J, Papadopoulos V (2013) De novo synthesis of steroids and oxysterols in adipocytes. 2nd Congress on Steroid Research, March 3, Chicago, IL, USA
265. Martinez–Arguelles DB, McIntosh M, Rohlicek C, Culty M, Zirkin BR, Papadopoulos V (2013) In utero exposure to di-(2-ethylhexyl) phthalate decreases aldosterone and blood pressure in the adult male offspring. 2nd Congress on Steroid Research, March 3, Chicago, IL, USA
266. Sakai M, Martinez-Arguelles D, Papadopoulos V (2013) In search of de novo steroid biosynthesis in human prostate cell lines and biopsies. American Society of Andrology, 38th Annual Conference, April 13-16, San Antonio, TX, USA
267. Chung J, Chen H, Midzak A, Papadopoulos V, Zirkin BR (2013) Drug ligand-induced activation of transocator protein (TSPO) stimulates steroid production by Leydig cells from the testes of aged Brown Norway rats. American Society of Andrology, 38th Annual Conference, April 13-16, San Antonio, TX, USA
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268. Aghazadeh Y, Culty M, Papadopoulos V (2013) The 14-3-3ε adaptor protein functions as a hormone-depended mitochondrial scaffold protein controlling TSPO-VDAC1 interactions and steroid formation in testis Leydig cells. Endocrine Society Annual meeting, June 15-18, San Francisco, CA, USA
269. Campioli E, Martinez-Arguelles DB, Papadopoulos V (2013) In utero exposure to di-(2-ethylhexyl) phthalate (DEHP) promotes inflammation and alters the adipose tissue gene expression in the adult male offspring. Endocrine Society Annual meeting, June 15-18, San Francisco, CA, USA
270. Issop L, Rone MB, Papadopoulos V (2013) Role of ATAD3 in inter-organelle interactions in hormone-induced Leydig cell steroidogenesis. Endocrine Society Annual meeting, June 15-18, San Francisco, CA, USA
271. Rone MB, Midzak A, Martinez DB, Blonder J, Veenstra T, Papadopoulos V (2013) Hormone-induced changes in the lipid transport and metabolism protein machineries in steroidogenic cell mitochondria. Endocrine Society Annual meeting, June 15-18, San Francisco, CA, USA
272. Midzak A, Brewster Z, Papadopoulos V (2013) Investigations into the phenotypic expression of endogenous benzodiazepine-like molecules in Leydig cells and implications for their role in steroid biosynthesis. Endocrine Society Annual meeting, June 15-18, San Francisco, CA, USA
273. Aghazadeh Y, Martinez-Arguelles DB and Papadopoulos V (2013) Role of 14-3-3ε adaptor protein - VDAC interactions in Leydig cell steroidogenesis in vivo. 46th Annual Meeting of the Society for the Study of Reproduction. July 22-26, Montreal, QC, Canada
274. Issop L, Rone MB, Papadopoulos V (2013) Role of ATAD3 in hormone-induced mitochondrial organization and steroidogenesis in MA-10 mouse tumor Leydig cells. 46th Annual Meeting of the Society for the Study of Reproduction. July 22-26, Montreal, QC, Canada
275. Lee J-S, Fan J, Papadopoulos V (2013) Intracellular localization of PEX11 protein family in mouse Leydig tumor cells. McGill Endocrine Retreat, McGill University, April 4, Montreal, QC, Canada
276. Fan J, Li X, Issop L, Papadopoulos V (2013) ACBD2/ECI2 protein mediates peroxisome-mitochondria interaction facilitating cholesterol import into mitochondria and steroid formation by Leydig cells. McGill Endocrine Retreat, McGill University, April 4, Montreal, QC, Canada
277. Sakai M, Martinez-Arguelles D, Elhilaly M, Papadopoulos V (2013) The GnRH antagonist Degarelix inhibits human prostate cell growth: leads in identifying its mechanism of action. 23rd Annual McGill Urology Research day, March 26, Montreal, Canada.
278. Papadopoulos V (2013) Function of the translocator protein TSPO in health and disease. Int J Mol Medicine 32:S1:122. Proceedings of the 16th International Symposium on Molecular Medicine, October 12-13, Creta Maris resort, Greece
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279. Aghazadeh Y, Martinez-Arguelles DB, Culty M, Papadopoulos V (2013) Role of 14-3-3ε adaptor protein - VDAC interactions in Leydig cell steroidogenesis in vivo. Annual Symposium of the “Reseau Quebecois en Reproduction”, November 12-13, Saint Hyacinth, Quebec, Canada
280. Issop L, Fan J, Lee S, Rone MB, Papadopoulos V (2013) Role of ATAD3 in ER-mitochondria communication in hormone-induced Leydig cell steroidogenesis. Annual Symposium of the “Reseau Quebecois en Reproduction”, November 12-13, Saint Hyacinth, Quebec, Canada
281. Mavrogonatou E, Papadopoulos V, Kletsas D (2013) Transcriptomic analysis of bovine nucleus pulposus intervertebral disc cells after hypoosmotic treatment. Hellenic Society for Computational Biology & Bioinformatics, November 11, Lamia, Greece
282. Rone M, Midzak AS, Martinzez-Arguelles D, Papadopoulos V (2014) MA-10 Leydig Cell Mitochondrial Metabolic Activity Regulates Steroid Production. American Society of Andrology 29th annual meeting, April 4-8, Atlanta, Georgia, USA
283. Midzak A, Akula N, Papadopoulos V (2014) Non-Steroidal Ligands of the Cholesterol Recognition Amino Acid Consensus (CRAC) Motif of the 18-kDa Translocator (TSPO) Protein and their Effects on Steroid Hormone Biosynthesis. American Society of Andrology 29th annual meeting, April 4-8, Atlanta, Georgia, USA
284. Issop L, Fan J, Lee S, Rone MB, Papadopoulos V (2014) Role of ATAD3 in the hormone- induced ER-mitochondrial organization in hormone-induced Leydig cell steroidogenesis. American Society of Andrology 29th annual meeting, April 4-8, Atlanta, Georgia, USA
285. Mavrogonatou E, Papadopoulos V, Kletsas D (2014) Transcriptional changes in nucleus pulposus intervertebral disc cells due to high osmolality, as revealed by cDNA microarray analysis. International Society for the Study of the Lumbar Spine, June 3-7, Seoul, Korea
286. Aghazadeh Y, Martinez-Arguelles DB, Fan J, Culty M, Papadopoulos V (2014) Induction of androgen formation in the male by a peptide blocking 14-3-3ε protein adaptor and mitochondrial VDAC1 interactions. International Congress of Endocrinology & Endocrine Society Annual meeting, June 21-24, Chicago, IL, USA
287. Martinez–Arguelles DB, Papadopoulos V (2014) In utero exposure to the endocrine druptor plasticizer di-(2-ethylhexyl) phthalate induces hot spots of DNA methylation correlated with regional gene expression changes in the adult male offspring. International Congress of Endocrinology & Endocrine Society Annual meeting, June 21-24, Chicago, IL, USA
288. Campioli E, Duong T, Papadopoulos V (2014) Cyclohexane-1,2-dicarboxylic acid mono isononyl ester (MINCH) affects epididymal rat stromal vascular fraction differentiation. McGill Endocrine Retreat, McGill University, May 22, Montreal, QC, Canada
289. Issop L, Fan |J, Lee S, Rone MB, Papadopoulos V (2014) The AAA+ATPase ATAD3 in the regulation of ER – mitochondria organization in Leydig cells. McGill Endocrine Retreat, McGill University, May 22, Montreal, QC, Canada
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290. Aghazadeh Y, Martinez-Arguelles DB, Fan J, Culty M, Papadopoulos V (2014) Induction of androgen formation in the male by a peptide blocking 14-3-3ε protein adaptor and mitochondrial VDAC1 interactions. McGill Endocrine Retreat, McGill University, May 22, Montreal, QC, Canada
291. Li J, Papadopoulos V (2014) 27-Hydroxycholesterol is an intracrine regulator of adipocyte function. McGill Endocrine Retreat, McGill University, May 22, Montreal, QC, Canada
292 Jagannathan SS, Chebbi S, Fan J, Hullin-Matsuda F, Kobayashi T, Papadopoulos V (2014) Origin of the steroidogenic pool of cholesterol used in hormone-induced acute steroid formation. Annual Symposium of the “Reseau Quebecois en Reproduction”, November 11-12, Quebec City, Canada
293. Odinokova I, Baburina Y, Krestinina O, Akatov V, Papadopoulos V, Reiser G, Lemasters J, Azarashvili T (2014). Combined effect of G3139 and TSPO ligands on induction of mPTP in purified rat brain mitochondria. Mitochondrial Stress Response Pathways: Functions and Applications of the 18kDa Protein TSPO. Biochemical Society, University of London, 16-17 December London, UK
294. Campioli E, Duong TB, Papadopoulos V (2015) Cyclohexane-1, 2-dicarboxylic acid diisononyl ester (DINCH) and metabolite effects on rat epididymal stromal vascular fraction differentiation of adipose tissue. Endocrine Society annual meeting, March 5-8, San Diego, CA, USA
295. Campioli E, Fan J, Midzak A, Culty M, Papadopoulos V (2015) Global knockout and steroidogenic cell-targeted deletion of the translocator protein (18-kDa) unveil its crucial role in viability and hormone-dependent steroid formation. Endocrine Society annual meeting, March 5-8, San Diego, CA, USA
296. Aghazadeh Y, Zirkin B, Papadopoulos V (2015) Translocator protein (TSPO) drug ligands induce testosterone formation in GnRH antagonist castrated rats. Endocrine Society annual meeting, March 5-8, San Diego, CA, USA
297. Jagannathan S, Chebbi S, Hullin-Matsuda F, Kobayashi T, Papadopoulos V (2015) Cholesterol trafficking for steroid biosynthesis in MA-10 mouse tumor Leydig cells. American Society of Biochemistry and Molecular Biology Annual Meeting Lipid Theme; Lipids – in vivo dynamics, protein partners and signaling. March 29-April 1, Boston, MA, USA
298. Midzak A, Fan J, Campioli E, Culty M, Papadopoulos V (2015) Targeted disruption of translocator protein (18-kDa) in Sf1-expressing steroidogenic cells impairs the ability of hCG and ACTH to stimulate steroid formation by the testis and adrenal. The XXIII North American Testis Workshop, April 15-18, Salt Lake City, Utah, USA
299. Jagannathan S, Chebbi S, Hullin-Matsuda F, Kobayashi T, Papadopoulos V (2015) Cholesterol trafficking for steroid biosynthesis in MA-10 mouse tumor Leydig cells. The XXIII North American Testis Workshop, April 15-18, Salt Lake City, Utah, USA
300. Midzak A, Fan J, Campioli E, Culty M, Papadopoulos V (2015) Targeted disruption of translocator protein (18-kDa) in Sf1-expressing steroidogenic cells impairs the ability of
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hCG and ACTH to stimulate steroid formation by the testis and adrenal. American Society of Andrology 40th Annual Meeting, April 18-21, Salt Lake City, Utah, USA
301. Jagannathan SS, Chebbi S, Hullin-Matsuda F, Kobayashi T, Papadopoulos V (2015) Origin of the steroidogenic pool of cholesterol used in hormone-induced acute steroid formation. American Society of Andrology 40th Annual Meeting, April 18-21, Salt Lake City, Utah, USA
302. Lee S, Martinez–Arguelles DM, Campioli E, Papadopoulos V (2015) In utero exposure to environmentally relevant doses of the plasticizer di-(2-ethylhexyl) phthalate predisposes the zona glomerulosa to endocrine disruption later in life. Drug Development Training Program annual retreat, McGill University, Montreal, QC, Canada
303. Issop L, Ostuni MA, Lacaper JJ, Papadopoulos V (2015) La mitochondrie dans tous ses états : rôle de la TSPO et ses partenaires. Group Francais de Bioenergetique. September 16-20, Strasbourg, France
304. Lee S, Martinez-Arguelles D, Papadopoulos V (2015) In utero exposure to an environmentally relevant dose of DEHP targets the adult adrenal gland for endocrine disruption. Annual Symposium of the “Reseau Quebecois en Reproduction”, November 17-18, Montreal, Canada
305. Li N, Fan J, Papadopoulos V (2015) Sterol Carrier Protein-2, a nonspecific lipid-transfer protein, in intracellular cholesterol trafficking in testicular Leydig cells. Annual Symposium of the “Reseau Quebecois en Reproduction”, November 17-18, Montreal, Canada
306. Lee S, Martinez-Arguelles DB, Papadopoulos V (2016) In utero exposure to DEHP alters steroidogenesis in the adult male offspring: reversibility of the effects using pharmacological means. American Society of Andrology Annual Meeting, April 2-5, New Orleans, USA
307. Venugopal S, Martinez-Arguelles DB, Papadopoulos V (2016) Identification of the source of cholesterol used for steroid biosynthesis in primary rat Leydig cells. American Society of Andrology Annual Meeting, April 2-5, New Orleans, USA
308. Campioli E, Lau M, Lee S, Papadopoulos V (2016) Effect of prenatal exposure to 1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH) on offspring testicular function. American Society of Andrology Annual Meeting, April 2-5, New Orleans, USA
309. Zhang H, Campioli E, Dalisson B, Papadopoulos V, Barralet J (2016) Long-term adipose tissue preservation by oxygen delivery. Canadian Society for Pharmaceutical Sciences Annual Symposium, May 31-June 3, 2016. River Rock Resort, Richmond (Vancouver), BC, Canada
310. Fan J, Papadopoulos V (2017) Introduction of Tspo gene mutations in MA-10 mouse Leydig tumor cells result in reduced steroid hormone formation. XXIV North American Testis Workshop, April 19-22, Miami, Florida, USA
312. Campioli E, Lau L, Lee S, Marques L, Papadopoulos V (2017) Prenatal exposure to 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) on offspring Leydig cells and
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testosterone production. XXIV North American Testis Workshop, April 19-22, Miami, Florida, USA
313. Venugopal S, Chan R, Esha S, Lorne T, Kaur P, Daly E, Papadopoulos V (2017) Hormone induced acute steroidogenesis mediates dynamic re-organization of subcellular membrane lipids in MA-10 mouse tumor Leydig cells. XXIV North American Testis Workshop, April 19-22, Miami, Florida, USA
314. Fan J, Papadopoulos V (2017) CRISPR/CAS9-mediated Tspo gene mutations lead to reduced mitochondrial membrane potential (Δψm) and steroid formation in MA-10 mouse Leydig tumor cells. American Society of Andrology, 42nd Annual Meeting, April 22-25, Miami, Florida, USA
315. Campioli E, Lau L, Lee S, Marques L, Papadopoulos V (2017) Testicular and metabolic effects of prenatal exposure to 1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH) in young and old Sprague Dawley male rats. American Society of Andrology, 42nd Annual Meeting, April 22-25, Miami, Florida, USA
316. Venugopal S, Chan R, Esha S, Lorne T, Kaur P, Daly E, Papadopoulos V (2017) Dynamic subcellular lipid organization in hormone induced MA-10 mouse tumor Leydig cells. American Society of Andrology, 42nd Annual Meeting, April 22-25, Miami, Florida, USA
