Curriculum Vitae Date Prepared: Sept 2017Curriculum Vitae Date Prepared: Sept 2017 Name: Su Chi LIM...

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Curriculum Vitae

Date Prepared: Sept 2017

Name: Su Chi LIM

Education:

1987 MBBS National University of Singapore, Singapore (M.D. equivalent)

1993 MRCP Royal College of Physician (Edinburgh), United Kingdom

1999 FAMS Endocrinology, Academy of Medicine, Singapore

2003 FRCP Royal College of Physician (Edinburgh), United Kingdom

2009 PhD Genetic and molecular epidemiology, National University of Singapore

Postdoctoral Training:

Internships (Duration of four months for each posting):

1987-1988 Internal Medicine, Singapore General Hospital, Singapore

1988 Pediatrics, Alexandra Hospital, Singapore

1988 Orthopedic, Toa Payoh Hospital, Singapore

Military Medical Officer (Rank: Captain)

1988-1990 Military Medicine, Singapore Arm Force, Singapore (21 months)

Residencies (Duration of six months for each posting):

1990-1991 Accident & Emergency Medicine, Singapore General Hospital, Singapore

1991 Internal Medicine, Alexandra Hospital, Singapore

1991-1992 Cardiovascular Medicine, Singapore General Hospital, Singapore

1992 Internal Medicine, Alexandra Hospital, Singapore

1992-1993 Transfusion Medicine, Blood Transfusion Service, Singapore

1993 Renal Medicine, Singapore General Hospital, Singapore

Clinical and Research Fellowships:

1993-1995 Internal Medicine/ Endocrinology, Singapore General Hospital, Singapore

1995- Endocrinology, Singapore General Hospital, Singapore

1997-1998 Clinical Research Fellow, Joslin Diabetes Center, Boston, USA.

2003-08 PhD student, Karolinska Institute-NUS International Graduate School of

Genetics & Molecular Epidemiology (GAME)

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Licensure and Certification:

1987 Medical Practitioner License (Provisional registration), Singapore

1988 Medical Practitioner License (Full registration), Singapore

1991 Education Commission for Foreign Medical Graduates, USA

1997 Test of English as Foreign Language (renewed)

1997 MiniMed Certified Pump Trainer

1999 Specialist Accreditation in Endocrinology, Ministry of Health, Singapore

Medical Council and Academy of Medicine, Singapore

Academic Appointments:

1993-97 Clinical Tutor, National University of Singapore

1996-97 Clinical Pharmacology Tutor, Belfast University, United Kingdom

1998- Clinical Teacher, National University of Singapore

2000- Clinical Teacher, Post-graduate Medicine, Endocrinology

2000- Supervisor, Advanced Specialty Training, Academy of Medicine, Singapore

2001 Master of Science (NUS), Thesis examiner. "Pathogenesis of Endothelial

Dysfunction in diabetes Syndrome."

2002 Master of Science (NUS), Thesis examiner. "Antibodies to GAD and IA2 in

Singaporean Diabetic: A two-part study"

2005 Adjunct Associate Professor, Centre for Molecular Epidemiology, Yong Loo

Lin School of Medicine, National University Hospital

2006 Adjunct Research Fellow, Singapore Eye Research Institute

2006 Medical Invigilator for M.Med (Int Med)/ MRCP Written Exams

2008 Medical Invigilator for M.Med (Int Med)/ MRCP PACES (SGH 26 Jan 08)

2008 Adjunct Associate Professor, Duke-National University of Singapore (Duke-

NUS) Graduate Medical School.

2011 Reviewer, Final grant proposal of graduate student. Master of Clinical

Investigation. Yong Loo Lin School of Medicine. Division of Graduate

Medical Studies.

2012 Adjunct Associate Professor with Lee Kong Chian School of Medicine

(LKCSoM), Nanyang Technological University

2015 Re-appointed as Adjunct Associate Professor with Lee Kong Chian School of

Medicine (LKCMedicine)

1 Sept 2017 Research Associate Professor in the Saw Swee Hock School of Public Health

(till 31 August 2020)

Hospital Appointments:

1987-1988 House Officer, Singapore General Hospital, Singapore

1988 Medical Officer, Singapore General Hospital, Singapore

1993 Medical Officer (Specialist), Singapore General Hospital, Singapore

1994 Registrar, Singapore General Hospital, Singapore

1997 Senior Registrar, Singapore General Hospital, Singapore

1999 Associate Consultant, Singapore General Hospital, Singapore

2000 Consultant, Singapore General Hospital, Singapore

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2001 Consultant, Dept of Medicine, Alexandra Hospital

2001 Deputy Director, Diabetes Centre, Alexandra Hospital.

2001 Visiting Consultant, Singapore General Hospital

2005-present Senior Consultant, Dept of Medicine, Khoo Teck Puat Hospital.

Other Professional Positions and Major Visiting Appointments:

1987- Member, Medical Defense Union/Medical Protection Society

1994- Member, Endocrine & Metabolic Society of Singapore

1994- Member, Diabetic Society of Singapore

1995-1997 Honorary Secretary, Endocrine & Metabolic Society of Singapore

1998- Ministry of Health, Guidelines development committee for management of

diabetes mellitus

1998- Executive member, Diabetic Society of Singapore

1998- Member, American Diabetes Association

1998- Member, European Association for study of Diabetes (EASD)

1999- Singapore representative, Action Against Diabetes in Asia (AADA).

1999- Sub-editor, e-journal club, Endocrine & Metabolic Society of Singapore

2000- Chairman, Education Subcommittee, Diabetic Society of Singapore (DSS)

2001- Chairman, Scientific Subcommittee, World Diabetes Day/DSS Annual

Scientific Meeting.

2001- Ad-hoc reviewer for Singapore Medical Journal.

2001- Member, Editorial panel, ExtraCare newsletter, Roche Diagnostic Pte Ltd.

2001- Ministry of Health representative to World Health Organization Western

Pacific Region Meeting for the development of a plan of action 2001-2005 for

the Western Pacific Declaration on Diabetes. 8-11 May 2001, Kaula Lumpur,

Malaysia.

2000- Member, GalxoSmithKline Asia Pacific Insulin Resistance Advisory Board.

2002- Chairperson, Hong Kah Diabetes Care and Counseling Centre (DECC)

Advisory Subcommittee, DSS

2002 Member, National Health Group Insulin Initiation at Polyclinics Workgroup

2002- Chairman, Education Subcommittee, Endocrine & Metabolic Society of

Singapore (EMS)

2002 Member, Workgroup, Clinical Classification Committee, MOH

2002 Chairperson, Association of Diabetes Educators Singapore (ADES) - Diabetic

Society of Singapore (DSS) - Endocrine & Metabolic Society of Singapore

(EMS) Diabetes Nurse Educator Accreditation & Certification Board.

2002 Vice President, Diabetic Society of Singapore

2002 Deputy representative for Alexandra Hospital, National Health Group

Research Committee

2003 Representative for Alexandra Hospital, National Health Group Research

Committee

2003 Representative for Alexandra Hospital, National Medical Research Council

2003 Member, organizing committee, National Health Group Annual Scientific

Meeting 2004

2003 Member, Atherothrombosis Forum (Supported by Sanofi-synthelabo/Bristol-

Myers Suibb)

2003-4 1st Vice-Chairman, Scientific Sub-Committee, NHG Annual Scientific

Congress 2004 Organizing Committee.

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2004 Coordinator, Endocrine & Metabolic Society of Singapore, Diabetes Research

Interest Group

2004 Member, National Health Care Group (NHG) workgroup on Hypertension

Prescribing Guidelines.

2004- Ad-hoc reviewer, Atherosclerosis Journal

2004 Ad-hoc reviewer, International Journal of Obesity & Related Metabolic

Disorders.

2005 Ad-hoc reviewer, Singapore General Hospital Proceedings.

2005 Member, Sanofi-Aventis Acomplia Regional Advisory Board.

2005 Member, Sanofi-Aventis Microalbuminuria National Advisory Board.

2005 Member, NHG Scientific Review Committee (SRC)

2005 Member, NHG Research Policy Review Committee (RPRC)

2006-2009 Member, Steering Committee, NUS Leadership in Academic Medicine

(NLAM) Program, Clinician Scientist Unit (CSU)

2006 Co-opted member, Education Subcommittee, Endocrine & Metabolic Society

of Singapore.

2006 Ad-hoc Reviewer. Yong Loo Lin School of Medicine, Academic Research

Fund

2006 NHG Representative, Joint management committee for Clinical Trial &

Epidemiological Research Unit (CTERU)

2006 Adjunct Research Fellow, Singapore Eye Research Institute

2006 NHG clinician-scientist Mentorship and Assessment Programme (MAP)

teaching Faculty

2007 Member. Ministry of Health (MOH) Stroke & Transient Ischaemic Attacks

(Review) Clinical Practice Guidelines committee

2007 Member, Sanofi-Aventis Singapore Diabetes Advisory Board.

2007 Member, Scientific Subcom, National Health Group Annual Scientific

Congress "INNOVATIVE MEDICINE - synergising research with clinical

practice"

2007-2009 Teaching Faculty, NHG-NUS Clinician Leadership in Research Programme

2007 Ad-hoc reviewer, Singapore Cancer Society, Run for hope Cancer Research

Grants

2007-2009 Member, Scientific Review Panel (SRP-2), National Medical Research

Council (NMRC).

2007 Ad-hoc Reviewer, BioMed Central, Medical Genetics.

2008-2010 Co-opted member, Endocrine & Metabolic Society of Singapore Executive

Committee

2008 Track Leader, Chronic Diseases Track (Metabolic Diseases), Scientific

Subcom, National Health Group Annual Scientific Congress "Science,

Medicine & Lifestyle - Impact on Tomorrow's Health.".

2008 Diabetes Workshop Coordinator. Dukes-NUS Medical School.

2008 Member, Quality Assurance Panel, Committee Academic Clinical Research

Organisation (ACRO), NMRC, MOH

2009 Ad-hoc reviewer, Archives of Medical Research

2009 Ad-hoc reviewer, Annals of Academy of Medicine, Singapore.

2009 Working committee on integrated care pathway, MOH (Lead, Diabetes sub-

workgroup)

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2009 Track Leader, Chronic Diseases Track (Endocrine & Metabolic Diseases),

Scientific Subcom, National Health Group Annual Scientific Congress "

Medicine in Asia Transforming Global Healthcare, Empowering Lives".

2009-12 Member (re-appointment), Scientific Review Panel (SRP-2), National Medical

Research Council (NMRC).

2009 PhD Thesis Oral Examine (panel member) for Dr Sabanayagam Charumathi,

Department of Opthalmology, Yong Loo Lin School of Medicine, NUS

2010-12 Singapore Medical Council Medical Practitioners Complaint Panel Member (3

April 2010 to 2 April 2012)

2010 Reviewer, The Endocrine Society journals.

2010 Ad-hoc reviewer, Diabetes Research and Clinical Practice Journal

2010 Track Leader (Endocrine & Metabolic Diseases), 1st Singapore Health &

Biomedical Congress “Improving health in our community: A holistic and

integrated approach” 12th

& 13th

November 2010.

2010-2012 Associate Editor, Journal of ASEAN Federation of Endocrine Society

(JAFES)

2011 Member, Ministry of Health (Singapore) Diabetes Mellitus Clinical Practice

Guidelines (CPG) Workgroup

2011 Member, Scientific Review Committee (SRC), NHG-KTPH Small Innovative

Grant

2011-12 Teaching faculty, NHG-KTPH Clnicain Leadership in Research Programme

2011 Member, Novartis Cardiovascular and Metabolism Advisory Board

2011 Member, Scientific Review Panel, 2nd Singapore Health and Biomedical

Congress 11-12 Nov 2011

2011 Ad-hoc Reviewer, Diabetic Medicine.

2012-2013 Member, Local Review Panel, NMRC Clinician Scientist-Individual Research

Grant scheme (re-appointed till 2017)

2012 Member, National Health Group, Scientific Review Committee

2012 Member, Boehringer Ingelheim Linagliptin Advisory Board

2012 Editor, Medical bulletin for KTPH (from 21 March 2012 for 1 year)

2012 Ad-hoc Reviewer, Endocrine Connections.

2012 Chairman, Quality Assurance Committee, KTPH.

2013 Member, Ministry of Health (Singapore) Obesity Clinical Practice Guidelines

(CPG) Workgroup

2012 Ad-hoc Reviewer, Nutrition Journal (IF=2.48)

2013 Ad-hoc Reviewer, BMC Nephrology (IF=2.18)

2013 Ad-hoc Reviewer, European Journal of Endocrinology (IF=3.42)

2014 Member of the Clinical Trials Implementation Committee (CTIC), MOH.

2014 Ad-hoc Reviewer, Clinical Endocrinology (IF=3.396)

2014 Ad-hoc reviewer, Annals of Medicine

2015-18 Co-Chairman for NTU-NHG Metabolic Diseases Collaboration Grant Review

Committee

2015 Ad-hoc reviewer, Annals of Medicine

2015-2017 Member, Platform Oversight and Advisory Committee, Genome Institute of

Singapore

2016-2018 Member, Clinician-Scientist Preparatory Programme (CSPP), National Health

Group Research Development Office.

2016 Reviewer of the SHBC 2016 Scientific Competition for the Clinical Specialty

of Endocrinology and/or abstract category Allied Health & Clinical Research

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2016-18 National Medical Research Council. Member of the Bedside to Bench (B&B)

Local Review Panel [1 June 2016 to 30 June 2018]

2016 Chairperson, NMRC Centre Grant application committee, KTPH

2016 Chairperson, NMRC Centre Grant application committee, AHS

2016 Theme leader, NMRC Open Fund – Large Collaborative Grant application

committee.

2016-2019 Member, Duke-NUS/SHS Singapore Diabetes Advisory Group (SDAG).

2017-2018 Member, NMRC Clinician Scientist - Individual Research Grant (CS-IRG)

Local Review Panel (LRP)

2017-2019 Board Member, Chapter of Endocrinology, Academy of Medicine, Singapore.

2017- Member, Research Committee, National Health Group (Chaired by A/Prof

Lim Tock Han, Dy GCEO, NHG).

2017- Member, Clinical Adoption Workgroup (Chaired by Deputy Director of

Medical Services, Health Services Group, A/Prof Kenneth Mak), Precision

Medicine Coordination Office, Genomic Medicine Strategy Work Group

(GMSWG), MOH Research Strategy Committee

2017- Ad-hoc Clinical Advice for HSA (Zafatek), Health Products Regulation Group

9/2017-8/2019 Workgroup member, NHG Clinical Trial Committee (NCTC).

Other Hospital Appointments

1999- Chairman, Evidence Based Medicine Committee, Div of Medicine, SGH

Member, Patient accounts management task force, SGH

2000- Dept Representative, Division of Medicine Research Committee, SGH

Member, Hospital Inpatient Discharge Summary Task Force, SGH

2001- Coordinator, Diabetes Group Education Program, Dept of Endocrinology,

SGH

2002 Member, Point of Care Testing (POCT) Committee

2003 Clinical Director, Clinical Research Unit, Alexandra Hospital

2006 Clinical Director, Clinical Research Committee, Alexandra Hospital

2006 Co-leader, Hospital Planning Committee, Yi Shun General Hospital.

Laboratory section.

2015-17 Project Team Member, Alexandra Health System (AHS) Transformation

project, Customer-for-Life team (chaired by Mr Alvin Ong, CITO).

2015-16 Advisor, Organizing Committee. Alexandra Health Forum cum Nursing Fest

2016.

Awards and Honors:

1982-1987 Local Merit Scholarship (Singapore)

1996/97 Health Manpower Development Plan Fellowship (Ministry of Health,

Singapore). Joslin Diabetes Center, Boston, Massachusetts, USA

1997 Singapore General Hospital, Service Quality Award.

1998 National Medical Research Council Medical Research Fellowship (6 months)

34th

Annual Meeting of the EASD Travel Grant Award, Barcelona, Spain.

1999 Singapore General Hospital 10th

Annual Scientific Meeting Best Free Paper

(Medical)

2006 National Health Group, Service Champion Award

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2004 Health Manpower Development Plan Fellowship (Ministry of Health,

Singapore), Karolinska Institute, Stockholm, Sweden

2005 1st Singhealth-National Health Group Combined Scientific Meeting, Best

Poster (Medicine / Paeds)

2005-2008 National Medical Research Council Medical Research Fellowship (25% FTE)

2008-10 NHG Researcher Investigator Scientist Enabler (RISE) Grant (20% FTE)

2009 IDS Gold Medal (1st prize), Best Oral Presentation (senior author of the team,

Allied Health Section, presented by Ms Dollyn Quek Liying), 2nd

Alexandra

Health Research Forum, 25th

Apr 2009.

2009 6-week Health Manpower Development Plan Fellowship (Ministry of Health,

Singapore). Joslin Diabetes Center, Boston, Massachusetts, USA

2011 First Khoo Teck Puat Hospital Research Forum, Best Oral Paper, Team award

(Nurses & Allied Health). 18 & 19 Feb 2011.

2011 Alexandra Health, Service Champion (Silver) Award

2011-13 NHG Researcher Investigator Scientist Enabler (RISE) Grant (20% FTE)

2011 Senior Author, Bronze Medal, Best poster award. 2nd Singapore Healthcare

Biomedical Congress 11 & 12 November 2011

2012 Senior Author, 1st Prize, Best Oral presentation, 1

st Joint Alexandra Health

Forum and Nursing Fest 31st Aug - 1

st Sept 2012

2013 6-week Overseas Fellowship (12th

Nov - 25th

Dec) to United Kingdom

(University of Dundee, Scotland; Oxford Centre for Diabetes Endocrinology &

Metabolism; Royal Devon and Exeter Hospital, University of Exetor)

2013 Bronze medal, Best Poster Award (Basic science/Translational Research),

Singapore Health & Biomedical Congress 2013, 26th

& 27th

Sept 2013 Max

Atria@ Singapore Expo.

2013 Alexandra Health, Service Champion (Gold) Award

2014 Certificate of commendation, Role Model to the medical class of 2013, Yong

Loo Lin School of Medicine, NUS.

2014 Best Poster Award, 2nd

NKF Annual Scientific Meeting 22nd

March 2014,

Singapore

2014 Bronze medal, Best poster award (senior author), Basic Science / Translational

Research, Singapore Health & Biomedical Congress, 26 & 27 Nov 2014

2104 1st Prize (senior author), Oral Presentation (Basic Science), Alexandra Health

Forum cum AH Nursing Fest 2014, 8 Nov 2014

2014 1st Prize (senior author), Oral Presentation (Clinical (allied health)), Alexandra

Health Forum cum AH Nursing Fest 2014, 8 Nov 2014

2014 2nd

Prize (1st author), Oral Presentation (Clinical (allied health)), Alexandra

Health Forum cum AH Nursing Fest 2014, 8 Nov 2014

2014 6-week MOH Health Manpower Development Plan (HMDP) on Genomic

Medicine (15th

Nov - 25th

Dec) to Duke University at Durham, North Carolina

and University California San Francisco (UCSF).

2015 Bronze medal, Best poster award (senior author), Basic Science / Translational

Research. Singapore Health & Biomedical Conference (SHBC) 2nd

and 3rd

Oct

2015

2015 Best Oral Presentation (Overall), 18th

ASEAN Federation of Endocrine

Societies (AFES) Congress 10-13 Dec 2015, Kuala Lumpur Convention

Centre, Malaysia

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2015 Best Oral Presentation (Diabetes Section), 18th

ASEAN Federation of

Endocrine Societies (AFES) Congress 10-13 Dec 2015, Kuala Lumpur

Convention Centre, Malaysia

2015 Best Poster (Diabetes Section) Co-1st Author, 18

th ASEAN Federation of

Endocrine Societies (AFES) Congress 10-13 Dec 2015, Kuala Lumpur

Convention Centre, Malaysia

2016 Annals, Academy of Medicine, Singapore. Annals’ Gold Best Paper Award for

the paper “Fasting during Ramadan and Associated Changes in Glycaemia,

Caloric Intake and Body Composition with Gender Differences in Singapore”

First Author: Dr Ester Yeoh Chai Kheng, Senior Author: Dr Lim Su Chi

2016 27th

Aug, Alexandra Health Forum cum AH Nursing Fest. Top Oral Abstract

Awards (Clinical / Physician): Navigating through the Paradigm of Chronic

Kidney Disease in Type 2 Diabetes? Useful Lessons and Prediction Model

Based on a 13-Year Prospective Cohort Study. First Author: Dr Serena Low

Kiat Mun, Senior Author: Dr Lim Su Chi

2016 27th

Aug, Alexandra Health Forum cum AH Nursing Fest. Top Oral Abstract

Awards (Basic Science): Genomic medicine in diabetes - Whole Exome

Sequencing (WES) as a tool for identifying novel genetic variants responsible

for monogenic diabetes in a pedigree study. First Author: Dr Ang Su Fen,

Senior Author: Dr Lim Su Chi

2016 27th

Aug, Alexandra Health Forum cum AH Nursing Fest. Top Poster Abstract

Awards: (Basic Science): Novel association of NPAT variant and

gastrointestinal side effects of metformin in type 2 diabetes patients. First

Author: Dr Resham Lal Gurung, Senior Author: Dr Lim Su Chi

2016 27th

Aug, Alexandra Health Forum cum AH Nursing Fest. Commended Poster

Awards (Basic Science): Association of Fractalkine and Overt Albumin

Excretion in Type 2 Diabetes. First Author: Mr Melvin Wong Ding Sheng,

Senior Author: Dr Lim Su Chi

2016 7th

November. Ministry of Health. National Day Long Service Award.

2017-2019 NMRC CSA-INV: Clinician Scientist Award (CSA) Investigator (INV)

Category ($ 1555670.00 FOR 3 YEARS)

Major Research Interests:

1. Diabetic nephropathy (including genetic epidemiology)

2. Monogenic diabetes

3. Diabetes Mellitus and endothelial function

3. Metabolic consequence of bariatric surgery

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Research Funding Information:

Current:

1995-2000 Role: Principal Investigator

Funding Source: Endocrine & Metabolic Society of Singapore

Grant Title: Study of Bone Markers in Thyrotoxic Patients

1997-2000 Role: Co-investigator

Funding source: American Diabetes Assocaition

Study title: Endothelial function in pre and post menopausal diabetic

women with and without hormonal replacement therapy.


Funding Source: Parke-Davis

Grant title: Effect of insulin-sensitizing agent troglitazone on the

endothelial function of the micro- and macro-vasculature of subjects at

risk of type 2 diabetes and type 2 diabetes patients with and without

vascular complications

1998-2001 Role: Principal investigator

Amount: $9,965.25

Funding source: Singapore General Hospital Research Committee

Soluble Intercellular Adhesion Molecules (ICAM) and Vascular Cell

Adhesion Molecules (VCAM) in Fenofibrate Treated Dyslipidemic

Men with Type 2 diabetes.


Funding source: National Medical Research Council

Amount: $150,448

The effect of d-alpha-tocopherol (Vitamin E) on the endothelial of

subjects with type 2 diabetes (NMRC/0372/1999)


Funding source: Clinical Trial & Epidemiology Research Unit

(CTERU), Ministry of Health.

Herbal Use in Singaporean with Diabetes


Funding source: NovoNordisk

NN2344-1185 : A randomized, multi-centre, double-blind, parallel-

group, placebo-controlled trial to investigate the safety and efficacy of

five doses of DRF2593 in OHA-and/or diet-treated patients with Type

2 diabetes.

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Funding source: NovoNordisk

A multicentre, randomized, double-blind, cross-over comparison on

the long-term glycemic control in a twice daily regimen of biphasi

insulin aspart 30 (BIAsp 30) and biphasic human insulin 30/70

(NHI30/70) in Type 2 diabetes (Novomix trial)

2000 -2001 Role: Co-investigator

Funding source: Elli-Lilly

F3Z-FW IOMM Post-prandial Insulin


Funding source: NMRC

Amount: $29,800

Effectiveness of nurse clinician case manager and telemedicine in the

management of patients with uncontrolled diabetes mellitus.

(NMRC/0569/2001)


Funding source: SGH Research Committee

The effect of angiotensin converting enzyme (ACE) inhibitor and

angiotensin receptor blocker (ARB) on the endothelial and renal

function of subjects with type 2 diabetes (Pilot project)



Amount: $129,966:

The effect of angiotensin converting enzyme (ACE) inhibitor and

angiotensin receptor blocker (ARB) on the endothelial and renal

function of subjects with type 2 diabetes (nmrc/0518/2001)

2002-2003 Role: Co-Principal investigator

Funding source: National Health Group (NHG) Research Fund

Amount: S$33, 880.00

The Effects of a Low Glycaemic Index cum High Fibre Diet on the

Metabolic Control (blood glucose, lipid and body weight) in Patients

with Type 2 Diabetes Mellitus

2003-2004 Role: Collaborator

Funding source: National Health Group (NHG) Research Fund

The effect of Ramadan fasting on glycaemic control in Muslim diabetic

patients on oral hypoglycaemic agents or insulin as measured by

continuous interstitial glucose monitoring, fingerprick glucose

monitoring, fructosamine assay and glycated hemoglobin (HbA1c)

assay.

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2003 Role: Principle Investigator

Funding source: National Medical Research Council (Enabling grant)

Amount: S$ 9600

Relationship between polymorphism in the angiotensin II type 1

receptor and diabetes related vascular complications

2004 Role: Principle Investigator

Funding source: National Medical Research Council (Enabling grant)

Amount: S$ 13,980

Relationship between polymorphism in the p22phox C242T and

nephropathy due to type 2 diabetes

2004-2006 Role: Principle Investigator

Funding source: National Medical Research Council

Amount: $66,881.00

A randomized, double blind, placebo controlled trial to assess the

efficacy of 12 weeks of coenzyme Q10 at 200 mg per day on the micro-

circulatory endothelial function of 80 subjects with type 2 diabetes

(NMRC/0802/2003)


Funding source: National Health Care Group Cluster Research Fund.

Amount: $98,794.00

A preliminary study of the genetic & molecular epidemiology of

metabolic syndrome in Asians (NHG-STP 04001)


Funding source: National Medical Research Council.

Amount: $340,200.00

Epidemiological study of the metabolic syndrome and

microangiopathies in Asians (An ancillary study of The Singapore

Prospective Study Program, SP2) (NMRC/0863/2004)


Funding Source: Biomedical Research Council

Amount: $199,900

Molecular epidemiology of nephropathy secondary to type 2 diabetes

(05/1/37/19/419)


Funding Source: National Health Care Group, Small Innovative Grant

Amount: $77,200

Adrenomedullin gene polymorphisms and nephropathy secondary to

type 2 diabetes (SIG/06036)

2006-2010 Role: Principal-investigator

Funding source: Speedel

SPP301CRD15: A Phase III, randomized, double blind, placebo

controlled, parallel group study to assess the effect of the endothelin

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receptor antagonist avosentan on time to doubling of serum creatinine,

end stage renal disease or death in patients with type 2 diabetes

mellitus and diabetic nephropathy


Funding Source: Biomedical Research Council

Amount: $12,022,960

Singapore Consortium of Cohort Studies (SCCS) BMRC

05/1/21/19/425


Funding Source: Sanofi-aventis

Cresendo (EFC5826) – Comprehensive Reimonabant Evaluation Sutdy

of Cardiovascular ENDpoints & Outcomes. Randomized,

multinational, multicenter, double-blind, placebo-controlled, two-arm

parallel group trial of rimonabant 20 gm OD for reducing the risk of

major cardiovascular events in abdominally obese patients with

clustering risk factors.


Funding Source: NovoNordisk

Novo Nordisk Inhaled Insulin study


Funding Source: National Health Care Group, Small Innovative Grant

Amount: $100,000

Adrenomedullin receptor gene polymorphisms and nephropathy

secondary to type 2 diabetes (SIG/07014)


Funding Source: National Kidney Foundation

Amount: $140,000

Molecular epidemiology in Nephrology secondary to Type 2 Diabetes –

a sub study using urinary proteomics (NKFRC/2007/02).

2007-2009 Role: Co-Investigator

Funding Source: Endocrine & Metabolic Society of Singapore

Amount: $ 20,500.00

Differential Inflammatory Cytokine Gene Expression between Visceral

and Subcutaneous adipocytes in Obese Asian subjects - a pilot study.


Funding Source: National Health Care Group- Alexandra Health,

Small Innovative Grant II

Amount: $ 500,000.00

Genetic polymorphisms of Calcitonin Like Receptor (CLR)-Receptor

Activity Modifying Protein (RAMP) heterodimeric receptors for

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Adrenomedullin and diabetic nephropathy secondary to type 2 diabetes.

(SIGII/08005)


Funding Source: National Medical Research Council

Amount: $ 98,420.00

Functional genetic of adrenomedullin receptor gene in diabetic

nephropathy (EDG08may018).

2008- Role: Co-Investigator

Funding Source: Novartis

CSPP100E2337 A randomised, double-blind, placebo-controlled,

parallel-group study to determine whether, in patients with type 2

diabetes at high risk for cardiovascular and renal events, aliskiren, on

top of conventional treatment, reduces cardiovascular and renal

morbidity and mortality (ALTITUDE).

2009 - 2010 Role: Co-Investigator

Funding Source: Alexandra Health (Small Innovative Grant)

Amount: $48,700.00

Functional genetic and pharmaco-genetic of adiponectin gene in human

visceral pre-adipocytes

2009 - 2010 Role: Co-Investigator

Funding Source: Alexandra Health (Small Innovative Grant)

Amount: $ 100,000

Site specific adipocytes adiponectin gene expression (a substudy

among diabetic individuals) (SIG/09068)

2010-2012 Role: Principle-Investigator

Funding Source: National Kidney Foundation

Amount: $20,000

Urinary proteomics of progressive diabetic nephropathy using bio-

banked samples – a substudy of Molecular Epidemiology of

Nephropathy secondary to Type 2 diabetes (NKFRC/2010/01/01).

2010-2012 Role: Supervisor (supervisee & grant PI: Dr Marilyn Lee)

Funding Source: Endocrine & Metabolic Society Singapore

Amount: $10,200

Comparison between 250mcg vs 1mcg short Synacthen test in

evaluation of adrenal insufficiency in radiotherapy treated

nasopharyngeal carcinoma patients.

2010-2012 Role: Supervisor (supervisees/grant PI: Dr Sueziani & Dr Ester Yeoh)


Amount: $9,950

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Determinants of changes in body composition and metabolic profile

associated with fasting during the month of Ramadan in diabetes

patients.

2010-2012 Role: Supervisor (supervisee & grant PI: Dr Foo Joo Pin)


Amount: $7,970

Permanent Neonatal Diabetes and De Novo KCNJ11 Gene Mutation


Funding Source: Alexandra Health Endowment Fund-KTPH,

Small Innovative Grant II

Amount: $299,700.00

Genetic association of neutral endopeptidase (NEP) for adrenomedullin

and diabetic nephropathy seondary to type 2 diabetes (substudy of

DSRB C/00541). (SIGII/11001)


Funding Source: Alexandra Health Endowment Fund-KTPH,

Small Innovative Grant I

Amount: $92,000

Genetic association of natriuretic peptide precursor A (NPPA) and its

receptor system with diabetic nephropathy secondary to type 2 diabetes

(Substudy of DSRB-C/00/541). (SIG/11029)

2011-2013 Role: Principal Investigator (among 3 PIs)

Funding Source: National Medical Research Council, Program Project

Grant (PPG)

Amount: $1,998,774.00

Novel genetic and non-genetic risk factors for endothelial dysfunction

and diabetic micro-angiopathies. (NMRC/PPG/AH(KTPH)/2011)

2011-2013 Role: Collaborator (PI A/Prof Chen Peng from NTU)


Amount: $180,000

Angiotensin II receptors on adipocytes: study of the physiological

functions and therapeutic potentials for metabolic diseases


Funding source: AHPL SIG/12024

Amount: $94,000

Genome-wide association study using ethnic-specific exome-centric

nonsynonymous rare-variant microarray for diabetic nephropathy

secondary to type 2 diabetes (substudy of DSRB C/00/541).

2012-2015 Role: Collaborator

Funding source: NMRC $1,499,225.00

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Insulin Resistance and Mild Cognitive Impairment (MCI) in Older

Adults with Pre-Diabetes and Diabetes: Cognitive Effects of Lifestyle

Intervention and Metformin Treatment in a Randomized Controlled

Trial (CIRG12may033)


Funding source: AHPL $94,800

Biomarker (C-reactive protein) and major candidate genes (GCK,

HNF1α and HNF4α) mutations screening for monogenic diabetes using

next-generation (SIG/13038)

2013-2016 Role: Co-PI

Funding Source: AHPL Endowment Fund, SIG II $550,000

Roux-en-Y Gastric Bypass for BMI 27-32 Type 2 Diabetics vs Best

Medical Treatment - a Randomised Controlled Trial.

2013-2014 Role: Co-I

Funding source: Biomedical Science Industry Partner Office (A Joint

initiative by Biomedical Research Council & National Medical

Research Council) $520,000

Translational genetic approaches for stratifying adults with young onset

diabetes and diagnosing monogenic diabetes in Singapore

2014-2016 Role: Co-Investigator (PI: Dr Angela Moh)

Funding source: AHPL $50,000

An evaluation of the early metabolic effects of bariatric surgery on

weight-independent type 2 diabetes remission by metabolomics-based

approaches


Funding source: AHPL $489,670 SIG II/14001

Extended gene-panel exonic mutations screening for monogenic

diabetes – a follow-up study of Biomarker (C reactive protein) and

major candidate genes (GCK, HNF1a and HNF4a) mutations screening

for monogenic diabetes using next-generation sequencing (NGS)

among Asians with young-onset diabetes (SIG/13038).


Funding source: AHPL $100,000 SIG I/14033

Generation of human induced pluripotent stem cells (hiPSCs) from

subjects with a novel mutation in HNF1A gene for in vitro disease

modelling of maturity onset diabetes of the young 3 (MODY3).


Funding source: Biomedical Sciences Industry Partner Office,

$520,000

Stratified Medicine For Type 2 Diabetes: A Pilot Study to Identify

Novel Metabolomic Biomarkers For Risk Stratification Of Vascular

Complications In Multi-Ethnic Singaporeans.

16


Funding source: National Medical Research Council, CS-IRG

Amount: $ 1,499,980

Novel genetic and non-genetic risk factors for endothelial dysfunction

and diabetic micro-angiopathies – a follow-up prospective study.

CIRG13nov045



Genome-wide association study to identify renal function quantitative

trait loci (QTL) in a large cohort of Singapore Chinese with type 2

diabetes (substudy of DSRB C/00/541).

2015-2017 Role: Co-Principal Investigator


An evaluation of the early metabolic effects of bariatric surgery on

weight-independent type 2 diabetes remission by metabolomics-based

approaches.

2015-2018 Role: Co- Principal Investigator

Funding source: NKFRC/2015/01/11 $79,540

Role of zinc α2 glycoprotein in the development and progression of

albuminuria in type 2 diabetes patients with renal insufficiency

2015-2018 Role: Co-PI

Funding source: KTPH/SIGII/15203 $300,135

Identification of candidate protective genes for type 2 diabetes in

metabolically healthy obese individuals by whole exome sequencing

2016-2018 Role: PI

Funding source: KTPH/STARI $99,975

Screening in drug targetable obesity-related pathways for functional

genetic variations that may be linked to resistance to bariatric surgery-

induced weight

2016-2018 Role: Co-I


Pilot Study of Genes and Environment in Familial Clustering of Type 2

Diabetes-related complication in overweight T2DM patients.

2016-2018 Role: Co-I


A pilot prospective study on the pharmacogenetics of metformin

gastro-intestinal intolerance among Asian with type 2 diabetes to

facilitate personalised medicine.


17

Funding source: NMRC CSA-INV: Clinician Scientist Award (CSA)

Investigator (INV) Category ($ 155,5670.00 FOR 3 YEARS)

Metabolomics of progressive diabetic kidney disease in young-onset

type 2 diabetes – a prospective study.

2017-2022 NMRC $25M OPEN FUND LARGE COLLABORATIVE GRANT

(OF-LCG): DYNAMO: Diabetes studY on Nephropathy And other

Microvascular cOmplications. Lead-PI Thomas Coffman (Duke-NUS);

Theme 2: Tai E Shyong (YLLSOM, NUS); Theme 3: Wong Tien Yin

(SNEC); Theme 4: Lim Su Chi (KTPH)

Grant applied (pending results)

Venerable Yen Pei-NKF Research Fund $178,500. A pilot study to understanding the

relationship between obesity-related influences and ethnic disparity in susceptibility to

diabetic kidney disease in Singapore.

Research without Funding Information:

2014 Diabetes complications in Asians

18

Principal Clinical and Hospital Service Responsibilities:

1994- Registrar, Singapore General Hospital

1994- Quality Assurance Committee, Singapore General Hospital

1996- Junior Doctors Welfare Committee, Singapore General Hospital

1997- Senior Registrar, Singapore General Hospital

1998- Committee member, Evidenced Based Medicine, Singapore General Hospital

1999- Chief coordinator, MMed(Int Med)/MRCP examination, Singapore General

Hospital

1999- Chairman, Organizing Committee. Endocrine Update 1999. Singapore General

Hospital.

1999- Chairman, Evidence Based Medicine Committee, Medical Division, Singapore

General Hospital

Self Report of Teaching:

Singapore General Hospital

1994- Endocrinology, Lecturer to Interns and Residents (35 MD)

10 hours/year

1994- Internal Medicine, 2 Residents

52 hours/year

1996- Clinical Endocrinology, tutor;

1 postgraduate student in clinical pharmacology

100 hours/year

National University of Singapore

1994- Endocrinology, 60 medical students

9 hours/year

1994- Applied physiology, 20 medical students

4 hours/year

1994- Internal Medicine, 20 medical students

9 hours/year

19

Research Student

Undergraduate & pre-medical school.

1. Ms Lai Yirong (3rd

year medical student), Advanced Medical Study, Melbourne

University, Australia. July 2003 – May 2004

Thesis: Association between Common Polymorphisms of Endothelial Nitric Oxide

Synthase Gene and Overt Diabetic Nephropathy in Chinese with Type 2 Diabetes

2. Ms Tee Wan Wen (2nd

year science student), Vacation Internship, National University of

Singapore. Apr 04 – July 04

3. Mr Ng Zhi Xian (3rd

year Life Science Student), Industrial attachment, Singapore

Polytechnic Feb – Apr 08

4. Daniel Ying, Raffles Institute

5. Amos Lee, National Junior College

6. Gwyneth Lim, Hua Chong Institute

7. Sean Lau, Singapore American School

8. Carrisa Ng, National University of Singapore

9. Yuen Hoi Yee, National University of Singapore

10. Fung Wai Kit, National Junior College

11. Kylie Leong, Raffles Institute

12. Joel Chiew, 4th

year medical student, Queen’s University Belfast.

Postgraduate

Supervisor

2002-04

Ms Amy Vong

MSc (Dietetic) faculty of the University of Ulster & University of Hong Kong:

Thesis: The Effects of a Low Glycaemic Index Cum High Fibre Diet on the Metabolic

Control of Patients with Type 2 Diabetes Mellitus

2011-2 Dr Lee Eng Seng (Clinician Leadership in Research), NHG

2011-2 Dr Darren Seah (Clinician Leadership in Research), NHG

2011-2 Dr Benjamin Lam (Master in Family Medicine). KTPH

2015- Dr Melvin Leow Khee Shing NHG-NTU Clinician-scientist PhD program

Thesis: The Role of Infrared Thermography (IRT) and Magnetic Resonance

Imaging (MRI) in Brown Fat Evaluation and their Application to Study the

Effect of Thyroid Status on Brown Fat Activity and White Fat Partitioning

2012 Dr LIU Jian Jun, MBBS, PhD (post-doc), Clinical Research Unit (CRU)

2013 Dr Angela Moh, PhD (CRU)

2013 Dr ANG Su Fen, PhD (CRU)

2014 Dr Serna Low, MBBS, MPH

2015 Dr Zhang Xiao, PhD (CRU)

20

2015 Dr Resham, PhD (CRU)

2016 Ms Clara Tan, MSc (Genomic Medicine) conferred by University College

London.

2017 Dr Alvin Tan, Consultant Endocrinologist, TTSH (nominee for NMRC

Research Training fellowship)

External examiner

1. 2002 MSc (NUS) thesis: Pathogenesis of endothelial dysfunction in diabetes syndrome –

effects of high glucose on signal transduction during nitric oxide production

2. 2003 MSc (NUS) thesis: Antibodies to GAD and IA-2 in Singaporean Diabetics: A tow-

part study

3. 2004 PhD (NUS) thesis: Chronic Exposure to High Glucose and Fatty Acids Impairs

Bradykinin-Stimulated Nitric Oxide Production by Interfering with Phospholipase C-

implicated Signaling Pathway in Endothelial Cells: Evidence for the Involvement of Protein

Kinase C

4. 2009 Sabanayagam Charumathi PhD (NUS) thesis: Chronic kidney disease in Asians:

Prevalence, racial differences and relationship to traditional and novel risk factors.

5. 2012 Ooi Shu Qin PhD (NUHS) thesis. Expression and the secretion of human visfatin,

and its correlation with metabolic parameters in children.

6. 2017 Khoo Chin Meng MBBS PhD Candidate thesis examiner. PATHWAY TO INSULIN

RESISTANCE IN HUMANS: DISSECTING THE ROLE OF ETHNICITY, FAT DEPOTS

AND INTERMEDIARY METABOLITES

21

Original Reports:

1. Lim SC, Fok ACK, Ong YY. Patients outcome and intensive care resource allocation

using APACHE II. Singapore Med J. 1996; 37:488-491.

2. Koh LKH, Eng PHK, Lim SC, Tan CE, Khoo DHC, Fok ACK. Abnormal thyroid

function and adrenocortical function test results in intensive care patients. Ann Acad Med

Singapore 1996; 25:808-815.

3. Lim SC, Pillay P, Khoo D, Tan CE, Eng P, Ho SC. A case of pleuri-potent pituitary

macroadenoma. The Endocrinologist 1997; 7:189-191.

4 Khoo DHC, Fok ACK, Tan CE, Koh LKH, Lim SC, Eng PHK, Ho SC. TSH receptor

antibody levels in Singapore patients with autoimmune thyroid disease. Ann Acad Med

Sing 1997; 26:435-8.

5 Eng PH, Tan KE, Khoo DH, Tan CE, Lim HS, Lim SC, Koh LK, Ho SC, Tai ES, Fok

AC.Aldosterone to renin ratios in the evaluation of primary aldosteronism. Ann Acad

Med Singapore 1997 Nov;26(6):762-6

6 Lim SC, Lim HS, Tan CE, Wong ZW, Fong CM. A case report of a patient with bronchial

carcinoid tumor and late presentation of Cushing’s syndrome. Ann Acad Med Sing. 1998

27:272-6.

7 Lim SC, Fok ACK, Lim HS. In search of hyperglycemia - tracing the path that leads to the

new diagnostic criteria for diabetes mellitus. Singapore Medical Journal 1999; 40(8):542-

545.

8. Lim SC, Tan CE, Aw TC, Khoo D, Eng P, Ho SC, Tai ES, Fok ACK. A man with

osteoblastic metastasis and hypocalcemia. Singapore Medical Journal 2000;41(2):74-76.

9. DHC Khoo, PHK Eng, SC Ho, CE Tan, HS Lim, LKH Koh, SC Lim, ES Tai, ACK Fok

Agoitrous thyrotropin-binding inhibitory immunoglobulin (TBII) positive hypothyroidism

- clinical and biochemical differences compared to other forms of autoimmune thyroiditis.

J. Endocrinol. Invest.21 ( Suppl. to no. 4) pg. 68

10. PHK Eng, KEK Tan, DHC Khoo, EC Tan, HS Lim, SC Lim, LKH Koh, SC Ho, ES Tai,

ACK Fok. Aldosterone to renin ratios in the evaluation of primary aldosteronism Ann

Acad Med Singapore 1997 Nov;26(6):762-6

11. DHC Khoo, ACK Fok, CE Tan, LKH Koh, SC Lim, PHK Eng, SC Ho. Thyroid

Stimulating Hormone Receptor Antibody Levels in Singapore Patients with Autoimmune

Thyroid Disease. Annals Academy of Medicine Singapore. 1997 Vol.26 No.4 pp. 435-

438.

12. A Enrique Caballero, Rola Saouaf, Subodh Arora, Su C Lim, Frank W. LoGerfo, Edward

S Horton, Aristidis Veves. Reactivity of the micro- and macro-circulation is impaired in

those at risk for type 2 diabetes. Diabetes 48:1856–1862, 1999.

22

13. Lim SC, Caballero AE, Smakowski P, LoGerfo FW, Horton ES and Veves A. Impariment

in vascular reactivity and elevation of soluble intercellular adhesion molecule (ICAM)

and vascular cell adhesion molecule (VCAM) precede the development of

microalbuminuria and elevation of von Willebrand factor (vWF) in individuals with type

2 diabetes. Diabetes Care 1999;Vol 22:1865-1870

14. SC Lim, AE Caballero, S Arora, P Smakowski, EC Bashoff, FM Brown, FW LoGerfo, ES

Horton, A Veves. The effect of Gender and hormonal replacement therapy on the vascular

reactivity of healthy individuals and individuals with type 2 diabetes. Journal of Clinical

Endocrinology and Metabolism 1999; Vol. 84:4159-4164.

15. SC Lim, ES Tai, BY Tan SK Chew, CE Tan. Cardiovascular risk profile in individuals

with borderline glycemia: the impact of 1997 ADA diagnosis criteria and 1998 WHO

provisional report. Diabetes Care 2000;23:278-282.

16. Tai ES, Lim SC, Chew SK, Tan BY, Tan CE. Homeostasis model assessment in a

population with mixed ethnicity: the 1992 Singapore National Health Survey. Diabetes

Res Clin Pract 2000 Aug;49(2-3):159-68

17. Tan CE, Chew LS, Chio LF, Tai ES, Lim HS, Lim SC, Jayakumar L, Eng HK, Packard

CJ. Cardiovascular risk factors and LDL subfraction profile in Type 2 diabetes mellitus

subjects with good glycaemic control. Diabetes Res Clin Pract 2001 Feb;51(2):107-14

18. ES Tai, SC Lim, BY Tan, SK Chew, D Heng, CE Tan. Screening for diabetes mellitus - a

two-step approach in individuals with imparied fasting glucose porvoes detection of those

at risk of complications. Diabetic Medicine 2000;17:1-5.

19. HH Tan, CC Ong, SC Lim. Endothelial dysfunction in type 2 diabetes. SGH Proceedings

(In press)

20. H H Tan, HS Lim, S C Lim. Severe Diabetes in Remission: A Singapore's Perspective.

Asians. Ann Acad Med Singapore 2001:30:615-9

21. HH Tan, SC Lim latent onset diabetes in adults (LADA): a case series. Singapore Med J

2001 Vol 42(11) : 513-516

22. HH Tan, HK Tan, H S Lim, ASA Tan, SC Lim gestation al Diabetes

Mellitus: A call for systemic tracing . Ann Acad Med Singapore 2002;31:281-4

.

23. Su-Chi Lim, Bee-Yian Tan, Suok-Kai Chew, Chee-Eng Tan The relationship between

insulin resistance and cardiovascular risk factors in overweight/obese non-diabetic

individuals: the 1992 Singapore National Health Survey. Int J Obes Relat Metab Disord.

2002;26:1511-6

24. Caballero AE, Saouaf R, Lim SC, Hamdy O, Abou-Elenin K, O'Connor K, LoGerfo FW,

Horton ES, Veves A. The effects of troglitazone, an insulin sensitizing agent, on the

23

endothelial function in early and late type 2 diabetes. A placebo-controlled, randomized,

clinical trial. Metabolism 2003;52:173-80

25. Tan HH, Angela Koh FY, Lim SC. Recent advances in the pharmacological therapy of

Type 2 Diabetes Medical Progress 2003;30:41-48

26. Yey HL, SC Lim, AM Snodgrass. Refeeding oedema in anorexia nervosa. Singapore Med

J 2005;46(6): 308-310

27. S Tavintharan, SC Lim, CF Sum. Patient with low levels of high-density lipoprotein

cholesterol: to treat or not to treat. Singapore Med J 2005;46:519-528

28 Su Chi Lim, Trisse Goh, YiRong Lai, WanWen Tee, Angela Koh, XiaoHong Xu, Yew

Seng Wu, Eric Yap, Tavintharan Subramaniam, Chee Fang Sum. Relationship between

common functional polymorphisms of the p22phox gene (-930A>G & +242 C>T) and

nephropathy due to type 2 diabetes among Chinese. Diabetic Medicine 2006 23:1037-

1041

29 REACH Registry investigators. International prevalence, recognition, and treatment of

cardiovascular risk factors in outpatients with atherothrombosis. JAMA 2006;295:180-

189.

30. Kah-Guan Au Eong, Srinivasan Sanjay, Su-Chi Lim Treatment of age related Macular

degeneration. The Lancet 2006. 368:1235.

31 Su Chi Lim, Hwee Huan Tan, Siew Kheng Goh, Tavintharan Subramaniam, Chee Fang

Sum, It Koon Tan, Bee Lan Lee, Choon Nam Ong. Oxidative Burden in Pre-diabetic and

Diabetic Individuals: Evidence from Plasma Coenzyme Q10. Diabetic Med 2006 23:

1344-1349

32. Su Chi Lim, Angela Koh, Trisse Goh, Chin Lian Chua, Boon Ling Heng, Tavintharan

Subramaniam, Chee Fang Sum. Angiotensin Receptor Antagonist Versus Angiotensin

Converting Enzyme Inhibitor In Asian Subjects With Type 2 Diabetes And Albuminuria –

A Randomized Cross Over Study. Diabetes Obesity & Metabolism 2007 9:477-482

33. Tavintharan S, Lim SC, Sum CF. Apoliporotein E Genotype affects the response to Lipid-

Lowering Therapy in Chinese Patients with Type 2 Diabetes Mellitus. Diabetes Obes

Metab. 2007;9(1):81-6.

34. Lim, Su-Chi; Morgenthaler, Nils; Subramaniam, Tavintharan; Wu, Yew-Seng; Goh,

Siew-Kheng; Sum, Chee-Fang. The relationship between adrenomedullin, metabolic

factors and vascular function in individuals with type 2 diabetes mellitus. Diabetes Care

2007;30:1513-1519

34. Vivien CC LIM, SC LIM, LY YEOH, YM LEE, Pearl LEE, Jaclyn Ong, BH TEY, T

SUBRAMANIAM, Edwin SY CHAN, SUM Chee Fang. Lactate Levels in Asian Patients

with Type 2 Diabetes Mellitus on Metformin and Its Association with Dose of Metformin

and Renal Function. Int J Clin Pract. 2007;61:1829-33

24

35. Tavintharan S, Ong CN. Jeyaseelan K. Sivakumar M, Lim SC, Sum CF Reduced

mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: a

possible role in statin-induced hepatotoxicity? Toxicology and Applied Pharmacology

2007;223(2):173-9

36. Ling Choo Lim, Su Chi LIM, Kian Peng GOH, Vivien CC LIM, Rajmohan

LEKSHMINARAYANAN, Tavintharan SUBRAMANIAM, Chee Fang SUM Is

Universal Screening for detection of thyroid dysfunction in Early Pregnancy justified ?

Journal of Clinical Endocrinology and Metabolism 2007. 92:203-207.

37 Su Chi Lim, Choon Nam Ong, Rajmohan Lekshminarayanan, Siew Kheng Goh, Yuen

Yeng Ong, Bee Lan Lee, Tavintharan Subramaniam, Chee Fang Sum The Effect of

Coenzyme Q10 on Microcirculatory Endothelial Function of subjects with Type 2

Diabetes Mellitus. Atherosclerosis 2008;196:966–969

38 Anoop Shankar, Chenlei Leng, Kee Seng Chia, David Koh, E. Shyong Tai, Seang Mei

Saw, Su Chi Lim and Tien Yin Wong. Association between body mass index and chronic

kidney disease in men and women: population-based study of Malay adults in Singapore

Nephrol Dial Transplant (2007) 23:1910-8. doi: 10.1093/ndt/gfm878

39 Yeo Tiong Cheng, Chan Yiong Huak, Low Lip Ping, N. Venketasubramanian, Lim Su

Chi, Tay Jam Chin, Tan Ru San, Peter Eng, Jayaram Lingamanaicker. Risk Factor Profile

and Treatment Patterns of Patients with Atherothrombosis in Singapore : Insight from the

REACH Registry. Ann Acad Med Sing 2008; 37:367-71

40. Pan CY, Ho LT, Soegondo S, Prodjosudjadi W, Suwanwalaikorn S, Lim SC, Chan TM,6

Weng SCK, Thoenes M, Choi DS on behalf of DEMAND Study Investigators Prevalence

of albuminuria and cardiovascular risk profile in a referred cohort of type 2 diabetic

patients: An Asian perspective. Diabetes Technology and Therapeutics 2008; 10(5): 397-

403

41. Tien Y Wong, Ning Cheung, Wan Ting Tay, Jie Jin Wang, Tin Aung, Seang Mei Saw,Su

Chi Lim, E Shyong Tai, Paul Mitchell Prevalence and Risk Factors for Diabetic

Retinopathy: The Singapore Malay Eye Study. Ophthalmology. 2008;115:1869-75

42 Subramaniam Tavintharan, Lim Su Chi, Sum Chee Fang, Armugam Arunmozhiarasi,

Kandiah Jeyaseelan. Riboregulators and metabolic disorders: getting closer towards

understanding the pathogenesis of diabetes mellitus? Current Molecular Medicine

2009;9:281-6

43 F M Amirul Islam, Thanh Nguyen, Jie Jin Wang E Shyong Tai, Anoop Shankar, Seang

Mei Saw, Tin Aung, Su Chi Lim, Paul Mitchell and Tien Y Wong. Quantitative Retinal

Vascular Calibre Changes in Diabetes and Retinopathy: The Singapore Malay Eye Study.

Eye (Lond). 2009;23:1719-24

44. Raj Mohan Lekshmi Narayanan, Lim Su Chi, , Lim Ling Choo, Yeoh Lee Ying and Sum

Chee Fang Renal outcomes in the ONTARGET study. The Lancet 2008. 372:2020

25

45.. Charumathi Sabanayagam, Anoop Shankar, Seang Mei Saw, Su Chi Lim E Shyong Tai,

Tien Yin Wong. Socioeconomic Status and Microalbuminuria in An Asian Population

Nephrol Dial Transplant 2009 24:123-129

46. Charumathi Sabanayagam, Anoop Shankar, David Koh, Kee Seng Chia, Seang Mei Saw,,

Su Chi Lim, E Shyong Tai, Tien Yin Wong. Retinal Microvascular Caliber and Chronic

Kidney Disease in an Asian Population. Am J Epidemiol 2009;169:625–632.

47. Charumathi Sabanayagam, Anoop Shankar, Su Chi Lim, E Shyong Tai, Tien Yin Wong

Hypertension and Hypertension Control and Chronic Kidney Disease in an Asian

Population. Asia Pac J Public Health. 2011;23:936-45.

48. S.C. Lim, J. J. Liu, H. Q. Low, N. G. Morgenthaler, Y. Li, L. Y. Yeoh, Y. S. Wu, S.K.

Goh, C. Y. Chionh, S. H. Tan, Y. C. Kon, P. C. Soon, Y. M. Bee, T. Subramaniam, C. F.

Sum, K. S. Chia. Microarray analysis of multiple candidate genes and associated plasma

proteins for nephropathy secondary to type 2 diabetes among Chinese. Diabetologia 2009

52:1343-51 (http://dx.doi.org/10.1007/s00125-009-1368-x)

49. Ei Ei Khaing Nang; Chin Meng Khoo; E. Shyong Tai; Su Chi Lim; Subramaniam

Tavintharan; Tien Yin Wong; Derrick Heng; Jeannette Lee Is There a Clear Threshold for

Fasting Plasma Glucose That Differentiates Between Those With and Without

Neuropathy and Chronic Kidney Disease?: The Singapore Prospective Study Program

American Journal of Epidemiology 2009 169:1454-1462; doi: 10.1093/aje/kwp076

50. Sabanayagam C, Liew G, Tai ES, Shankar A, Lim SC, Subramaniam T, Wong TY.

Relationship between glycated haemoglobin and microvascular complications: is there a

natural cut-off point for the diagnosis of diabetes? Diabetologia. 2009 52:1279-89

51. V Swetha E. Jeganathan; Tien Yin Wong; Paul J Foster; Jonathan Crowston1; Wan Ting

Tay; Su Chi Lim; Seang-Mei Saw; E Shyong Tai; Tin Aung Peripheral Artery Disease

and Glaucoma: the Singapore Malay Eye Study. Arch Ophthalmol. 2009;127:888-93

52. Sabanayagam C, Shankar A, Saw SM, Tai S, Lim SC, Lee JJ, Wong TY. Prevalence of

Diabetes Mellitus, Glycemic Control, and Associated Factors in a Malay Population in

Singapore. Asia Pac J Public Health. 2009;21:385-98

53. Tavintharan S, Ning Cheung, Su Chi Lim, Wanting Tay, Anoop Shankar, E Shyong Tai,

Tien Y Wong. Prevalence and Risk Factors for Peripheral Artery Disease in an Asian

Population with Diabetes Mellitus. Diabetes and Vascular Disease Research, 2009; 6: 80-

86.

54. Charumathi Sabanayagam, Jeannette Lee, Anoop Shankar, Su Chi Lim, Tien Y. Wong

and E. Shyong Tai C-reactive protein and microalbuminuria in a multi-ethnic Asian

population. Nephrol Dial Transplant. 2010 Apr;25(4):1167-72

55. Sng CC, Sabanayagam C, Lamoureux EL, Liu E, Lim SC, Hamzah H, Lee J, Tai ES,

Wong TY. Fractal analysis of the retinal vasculature and chronic kidney disease. Nephrol

Dial Transplant. 2010;25:2252-8.

26

56. Tai ES, Tan ML, Stevens RD, Low YL, Muehlbauer MJ, Goh DL, Ilkayeva OR, Wenner

BR, Bain JR, Lee JJ, Lim SC, Khoo CM, Shah SH, Newgard CB. Insulin resistance is

associated with a metabolic profile of altered protein metabolism in Chinese and Asian-

Indian men. Diabetologia. 2010 53:757-67.

57. Sabanayagam C, Lim SC, Wong TY, Lee J, Shankar A, Tai ES. Ethnic disparities in

prevalence and impact of risk factors of chronic kidney disease. Nephrol Dial Transplant.

2010;25:2564-70.

58. Nongpiur ME, Wong TY, Sabanayagam C, Lim SC, Tai ES, Aung T. Chronic kidney

disease and intraocular pressure: the Singapore Malay Eye Study. Ophthalmology. 2010

Mar;117(3):477-83.

59. Tavintharan S, K Woon, LT Pek, X Dong, N Jauhar, SC Lim, CF Sum. Niacin results in

reduced monocyte adhesion in patients with type 2 diabetes mellitus. Atherosclerosis

2011;215:176-9.

60 Kiong K L, Ganesh R, Cheng A K S, Lekshiminarayanan R, Lim S C Early improvement

in type 2 diabetes mellitus post Roux-en-Y gastric bypass in Asian patients. Singapore

Med J 2010; 51:937

61. Tavintharan S, Ei Ei Khaing Nang, Su Chi Lim, Yi Wu, Chin Meng Khoo, Jeannette Lee,

Derrick Heng, Suok Kai Chew, Tien Y Wong, E Shyong Tai. Distribution of ankle

brachial index and the risk factors of peripheral artery disease in a multi-ethnic Asian

population. Vasc Med 2011 16: 87

62. Sabanayagam C, Shankar A, Lim SC, Lee J, Tai ES, Wong TY. Serum C-reactive protein

level and prediabetes in two Asian populations. Diabetologia (2011) 54:767–775

63. Arunmozhiarasi Armugam, Subramaniam Tavintharan, Michael T. K. Wong, Su Chi Lim,

Chee Fang Sum, Kandiah Jeyaseelan. MicroRNA 144 Impairs Insulin Signaling by

Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus.

Dwi Setyowati Karolina1, PLoS ONE 6(8): e22839. doi:10.1371/journal.pone.0022839

64. Lim Su-Chi, Clara Tan. Comment on: Evolution of Renal Hyperfiltration and Arterial

Stiffness From Adolescence Into Early Adulthood in Type 1 Diabetes. Diabetes Care

2011; 34: e182 (DC111528).

65. Su Chi Lim, Dollyn Quek Liying, Wan Ching Toy, Melvin Wong DS, Lee Ying Yeoh,

Cherine Tan MF, Dawn Lau, Clara Tan, Tavintharan Subramaniam, Chee Fang Sum.

Adipocytokine zinc alpha-2 glycoprotein (ZAG) as novel urinary biomarker for normo-

albuminuric diabetic nephropathy. Diabetic Medicine 2012;29:1-5

66. Toy Wan Ching, Liu Jian-Jun, Anton Cheng Kui Sing, Clara Tan, Dawn Lau, Melvin

Wong, Tavintharan Subramaniam, Sum Chee Fang, Lim Su Chi. Adiponectin Gene

Polymorphisms and Type 2 Diabetes among Singaporean Chinese Adults. J Diabetes

Metab 2011, 2:8

27

67. Foo Joo Pin, Richard Chen, Lim Su Chi, Goh Su Yuen on behalf of the Singapore

Clinical Practice Guidelines Writing Group. The Diabetes Mellitus Clinical Practice

Guidelines of Singapore – Looking Back and Ahead. Journal of ASEAN Federal

Endocrine Societies (JAFES) 2011;:31-34

68. Lim S Chi, Phua E Joo, Sharon F Nne, Amizah B Asrap, Wong DS Melvin, Tan SH

Clara, Liu J Jun, Toy W Ching, Ng X Wei, Lau PX Dawn, Pek LT Sharon, Woon Kaing,

Lin LF Bernice, S Tavintharan, Sum C Fang. Modifiable risk factors associated with

arterial stiffness in diabetic nephropathy in an Asian Population Cohort. Journal of

ASEAN Federal Endocrine Societies (JAFES) 2011; 26:163-167

69. Hoe J, Koh WP, Jin A, Sum CF, Lim SC, Tavintharan S. Predictors of decrease in ankle-

brachial index among patients with diabetes mellitus. Diabetic Med 2012;29:e304-7

70. Asia Genetic (AGEN) investigators: Yukinori Okada, Xueling Sim, Min Jin Go, Jer-

Yuarn Wu, Dongfeng Gu, Fumihiko Takeuchi, Atsushi Takahashi, Shiro Maeda,

Tatsuhiko Tsunoda, Peng Chen, Su-Chi Lim, Tien-Yin Wong, Jianjun Liu, Terri L

Young, Tin Aung, Mark Seielstad, Yik-Ying Teo, Young Jin Kim, Jong-Young Lee, Bok-

Ghee Han, Daehee Kang, Chien-Hsiun Chen, Fuu-Jen Tsai, Li-Ching Chang, S-J Cathy

Fann, Hao Mei, Dabeeru C Rao, James E Hixson, Shufeng Chen, Tomohiro Katsuya,

Masato Isono, Toshio Ogihara, John C Chambers, Weihua Zhang, Jaspal S Kooner, The

KidneyGen Consortium, The CKDGen Consortium, Eva Albrecht, The GUGC

consortium, Kazuhiko Yamamoto, Michiaki Kubo, Yusuke Nakamura, Naoyuki

Kamatani, Norihiro Kato, Jiang He, Yuan-Tsong Chen, Yoon Shin Cho, E-Shyong Tai &

Toshihiro Tanaka. Genome-wide meta-analysis identified multiple loci associated with

kidney function measures in East Asian populations. Nature Genetics 2012; 44:904-909

71. Venkataraman K, Wee HL, Leow MK, Tai ES, Lee J, Lim SC, Tavintharan S, Wong TY,

Ma S, Heng D, Thumboo J. Associations between complications and health-related

quality of life in individuals with diabetes. Clin Endocrinol (Oxf). 2013;78:865-73

72. Liu JJ, Tavintharan S, Sum CF, Lim SC. Comment on: Singer et al. Adiponectin and all-

cause mortality in elderly people with type 2 diabetes. Diabetes Care 2012;35:1858-1863.

Diabetes Care. 2013 Jun;36(6):e78.

73. Su Chi Lim, Jian-Jun Liu, Tavintharan Subramaniam and Chee Fang Sum. Elevated

circulating alpha-klotho by angiotensin II receptor blocker losartan is associated with

reduction of albuminuria in type 2 diabetic patients. J Renin Angiotensin Aldosterone

Syst. 2014 Dec;15(4):487-90.

74. Dwi Setyowati Karolina, Subramaniam Tavintharan, Arunmozhiarasi Armugam,

Sugunavathi Sepramaniam, Sharon Li Ting Pek, Michael T. K. Wong, Su Chi Lim, Chee

Fang Sum, and Kandiah Jeyaseelan Circulating miRNA Profiles in Patients with

Metabolic Syndrome J Clin Endocrinol Metab 2012 97: E2271-E2276;

75. Jian-Jun Liu, Wan C Toy; Sylvia Liu; Anton Cheng; Boon Khim Lim; Tavin

Subramaniam; Chee Fang Sum; Su Chi Lim. Acetyl-keto-β-boswellic acid induces

lipolysis in mature adipocytes. Biochemical and Biophysical Research Communications

431 (2013) 192–196

28

76. Jian-Jun Liu, Wan Ching Toy, Melvin Ding Sheng Wong, Clara Si Hua Tan,

Subramaniam Tavintharan; Moh Sim Wong, Chee Fang Sum and Su Chi Lim. Elevated

undercarboxylated and reduced carboxylated osteocalcin are associated with metabolic

syndrome in middle age Asian females. Exp Clin Endocrinol Diabetes. 2013;121:329-33.

doi: 10.1055/s-0033-1334883.

77. Sharon Pek Li Ting; Woon Kaing; Niyati Jauhar; Lim Su Chi; Sum Chee Fang,

Tavintharan Subramaniam. The associations between Pigment Epithelium-Derived

Factor, insulin resistance and High Density lipoprotein. Diabetic Medicine 2013 30:1067-

74. doi: 10.1111/dme.12198

78. Jian-Jun Liu, Melvin DS Wong, Wan Ching Toy, Clara SH Tan, Sylvia Liu, Xiao Wei

Ng, Subramaniam Tavintharan, Chee Fang Sum and Su Chi Lim. Lower circulating irisin

is associated with type 2 diabetes mellitus. J Diabetes Complications. 2013;27:365-9.

79. Xu F#, Tavintharan S#, Sum CF, Woon K, Lim SC, Ong CN. Metabolic Signature Shift

in Type 2 Diabetes Mellitus Revealed by Mass Spectrometry-based Metabolomics. J Clin

Endocrinol Metab. 2013 Jun;98:E1060-5. # equal contributions

80. Laurence Shen Lim, Carol Yim-lui Cheung, Charumathi Sabanayagam, Su Chi Lim, E

Shyong Tai, Huang Lei, Tien Yin Wong. Structural Changes in the Retinal

Microvasculature and Renal Function. Invest Ophthalmol Vis Sci. 2013;54:2970-6

81. Lam Chih Chiang, Benjamin, Michael Wong, Lim Su Chi, Eugene Shum, Gerald C H

Koh. A Method-Comparison Study to Validate a Novel Parameter of Obesity, the Body

Adiposity Index (BAI), in Chinese Subjects. Obesity (Silver Spring). 2013;21:E634-9

82. Jian-Jun Liu, Sylvia Liu, Melvin DS Wong, Clara SH Tan, Subramaniam Tavintharan,

Chee Fang Sum and Su Chi Lim. Relationship between circulating irisin, renal function

and body composition in type 2 diabetes. J Diabetes Complications. 2014;28:208-13

83. Jian-Jun Liu, Sylvia Liu, Nils G Morgenthaler, Melvin DS Wong, Subramaniam

Tavintharan, Chee Fang Sum, Su Chi Lim. Association of plasma soluble alpha-klotho

with pro-endothelin-1 in patients with type 2 diabetes. Atherosclerosis 2014

2014;233:415-418.

84. Jian-Jun Liu, Subramaniam Tavintharan, Lee Ying Yeoh, Chee Fang Sum, Xiao Wei Ng,

Sharon LT Pek , Simon BM Lee, Wern Ee Tang and Su Chi Lim for SMART2D study.

High normal albuminuria is independently associated with aortic stiffness in patients with

type 2 diabetes. Diabetic Medicine 2014; (10):1199-1204

85. Sabanayagam, Charumathi; Foo, Valencia; Ikram, Kamran; Huang, Huiqi; Singapore Eye

Research Institute (SERI), Lim, Su Chi; Lamoureux, Ecosse; Tai, E Shyong; Wong, Tien

Yin; Is Chronic Kidney Disease associated with Diabetic Retinopathy in the Absence of

Albuminuria? J Diabetes. 2014;6:556-63

86. Cynthia C Lim, Boon Wee Teo, Peng Guan Ong, Carol Y Cheung, Su Chi Lim, Khuan

Yew Chow, Chan Choon Meng, Jeannette Lee, E Shyong Tai, Tien Y Wong, Charumathi

29

Sabanayagam. Chronic Kidney Disease, Cardiovascular Disease and Mortality: A

Prospective Cohort study in a Multi-ethnic Asian population. Eur J Prev Cardiol.

2015;22:1018-26

87. S Tavintharan, Li Ting Sharon Pek, Jian Jun Liu, Xiao Wei Ng, Lee Ying Yeoh, Su Chi

Lim and Chee Fang Sum. Osteoprotegerin is independently associated with Metabolic

Syndrome and microvascular complications in Type 2 Diabetes Mellitus. Diabetes &

Vascular Disease Research 2014;11:359-362

88. Liu Jianjun; Sum Chee Fang; Subramaniam Tavintharan; Yeoh Lee Ying; Ng Xiao Wei;

Angela Moh Mei Chung; Simon Lee Biing Ming; Tang Wern Ee; Lim Su Chi. Obesity is

a determinant of arterial stiffness independent of traditional risk factors in Asians with

young- onset type 2 diabetes. Atherosclerosis 2014;236:286-291

89. Dwi Setyowati Karolina, Arunmozhiarasi Armugam, Sugunavathi Sepramaniam, Sharon

Li Ting Pek, Michael TK Wong, Su Chi Lim, Chee Fung Sum, Subramaniam

Tavintharan, and Kandiah Jeyaseelan. miR-22 and miR-23a Control Glycerol-Dependent

Gluconeogenesis by Regulating Aquaporin 9 Expression. Metabolomics 2014, S:2

http://dx.doi.org/10.4172/2153-0769.S2-002

90. Mei Chung Moh, Chee Fang Sum, Benjamin Chih Chiang Lam, Xiao Wei Ng, Chang Su,

Subramaniam Tavintharan, Lee Ying Yeoh, Melvin Ding Sheng Wong, Simon Biing

Ming Lee, Wern Ee Tang, Su Chi Lim. Evaluation of body adiposity index (BAI) as a

predictor of arterial stiffness in multi-ethnic Asian population with type 2 diabetes.

Diabetes & Vascular Disease Research 2015;12:111-118

91. Sabanayagam C, Khoo EY, Lye WK, Ikram MK, Lamoureux EL, Cheng CY, Tan ML,

Salim A, Lee J, Lim SC, Tavintharan S, Thai AC, Heng D, Ma S, Tai ES, Wong TY.

Diagnosis of Diabetes Mellitus using HbA1c in Asians: Relationship between HbA1c and

Retinopathy in a Multi-Ethnic Asian Population J Clin Endo & Metab 2015;100: 689 –

696

92. Sharon LT Pek, S Tavintharan, Xiaomeng Wang, Su Chi Lim, Kaing Woon, Lee Ying

Yeoh, Xiaowei Ng, Jianjun Liu, Chee Fang Sum. Elevation of a novel angiogenic factor,

Leucine-Rich-α2-Glycoprotein (LRG1), is associated with arterial stiffness, endothelial

dysfunction and Peripheral Arterial Disease in patients with Type 2 Diabetes. J Clin

Endocrinol Metab 100: 1586 –1593, 2015

93. Jian-Jun Liu, Joo Pin Foo, Sylvia Liu, Su Chi Lim. The role of fibroblast growth factor 21

in diabetes and its complications: a review from clinical perspective. Diabetes Res Clin

Pract. 2015;108:382-9

94. Jian-Jun Liu, Lee Ying Yeoh, Chee Fang Sum, Subramaniam Tavintharan, Xiao Wei Ng,

Sylvia Liu, Simon BM Lee, Wern Ee Tang and Su Chi Lim. Vascular cell adhesion

molecule-1, but not intercellular adhesion molecule-1, is associated with diabetic kidney

disease in Asians with type 2 diabetes. Journal of Diabetes and Its Complications 2015;

29:707–712.

30

95. Xiao Zhang, Jian Jun Liu, Chee Fang Sum, Yeoh Lee Ying, Subramaniam Tavintharan,

Xiao Wei Ng, Serena Low, Simon BM Lee, Wern Ee Tang, Su Chi Lim. Ethnic disparity

in central arterial stiffness and its determinants among Asians with type 2 diabetes.

Atherosclerosis 242 (2015) 22-28

96. Varadarajan Baskar, Chee Fang Sum, Su Chi Lim. Prednisone for community-acquired

pneumonia: not yet time. The Lancet 2015;386:431

97. Low SK, Sum CF, Yeoh LY, Tavintharan S, Ng XW, Lee SB, Tang WE, Lim SC.

Prevalence of Chronic Kidney Disease in Adults with Type 2 Diabetes Mellitus. Ann

Acad Med Singapore. 2015;44:164-71.

98. Yeoh EC, Zainudin SB, Loh WN, Chua CL, Fun S, Subramaniam T, Sum CF, Lim SC.

Fasting during Ramadan and Associated Changes in Glycaemia, Caloric Intake and Body

Composition with Gender Differences in Singapore. Ann Acad Med Singapore.

2015;44:202-6.

99. JJ Liu*, SC Lim*, LY Yeoh, C Su, BC Tai, S Low, S Fun, S Tavintharan, KS Chia, ES

Tai and CF Sum. Ethnic disparities in risk of cardiovascular disease, end stage renal

disease and all-cause mortality- a prospective study among South East Asians with type 2

diabetes. Diabet Med. 2016;33:332-9

100. Serena Low, Lim Su Chi, Lee Ying Yeoh, Jian Jun Liu, Sharon Fun, Chang Su, Xiao

Zhang, Tavintharan Subramaniam, Chee Fang Sum. Long-term diabetes outcomes in

multi-ethnic Asians living in Singapore. Diab Res Clin Pract. 2016;111:83-92

101. Huo J, Ma Y, Liu JJ, Ho YS, Liu S, Soh LY, Chen S, Xu S, Han W, Hong A, Lim SC,

Lam KP. Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and

hepatosteatosis. Cell Death Dis. 2016 Feb 11;7:e2091

102. Mei Chung Moh, Chee Fang Sum, Subramaniam Tavintharan, Sharon Li Ting Pek, Lee

Ying Yeoh, Xiaowei Ng, Simon Biing Ming Lee, Wern Ee Tang, Su Chi Lim.

Association of the anti-angiogenic factor secreted protein and rich in cysteine (SPARC)

with vascular complications among Chinese type 2 diabetic patients in Singapore. Journal

of Diabetes and Its Complications 2016 (in press)

103. Pek SL, Sum CF, Lin MX, Cheng AK, Wong MT, Lim SC, Tavintharan S. Circulating

and visceral adipose miR-100 is down-regulated in patients with obesity and Type 2

diabetes. Mol Cell Endocrinol. 2016 Mar 10. pii: S0303-7207(16)30058-2. doi:

10.1016/j.mce.2016.03.010.

104. Serena Low, E Shyong Tai, Lee Ying Yeoh, Yan Lun Liu, Jian Jun Liu, Kristin Hui Xian

Tan, Sharon Fun, Chang Su, Xiao Zhang, Tavintharan Subramaniam, Chee Fang Sum, Su

Chi Lim. Onset and Progression of Kidney Disease in Type 2 Diabetes among Multi-

ethnic Asians Population. J Diabetes Complications. 2016;30:1248-54

105. Su Chi Lim*, Rajkumar Dorajoo*, Xiao Zhang, Ling Wang, Su Fen Ang, Clara Tan,

Yeoh Lee Ying, Xiao Wei Ng, Na Li, Chang Su, Sylvia Liu, Melvin Wong, Serena Low,

Amy Ou Yao, Jeevith Babitha, Sharon Fun, Shi Yi Zhou, Simon BM Lee, Wern Ee Tang,

31

Subramaniam Tavintharan, Chee Fang Sum, Jian-Jun Liu. Genetic variants in the receptor

for advanced glycation end products (RAGE) gene were associated with circulating

soluble RAGE level (sRAGE), but not with renal function among Asians with type 2

diabetes: a genome-wide association study. Nephrol Dial Transplant. 2016 Jul 21. pii:

gfw263. [Epub ahead of print] *denotes equal contribution.

106. Ang Su Fen*, Lim Su Chi*, Clara Tan SH, Jessie Fong CW, Winston Kon YC, Joyce

Lian X, Tavintharan Subramaniam, Sum Chee Fang. A preliminary study to evaluate the

strategy of combining clinical criteria and next generation sequencing (NGS) for the

identification of monogenic diabetes among multi-ethnic Asians. Diab Res Clin Pract.

2016;119:13-22. * denotes equal contribution. Featured article in Sept 2016 issue of Diab

Res Clin Pract (official journal of the International Diabetes Federation).

107 Xiao Zhang, Jian Jun Liu, Chee Fang Sum, Yeoh Lee Ying, Subramaniam Tavintharan,

Xiao Wei Ng, Chang Su, Serena Low, Simon BM Lee, Wern Ee Tang, and Su Chi Lim

Central arterial stiffness is associated with systemic inflammation among Asians with

type 2 diabetes. Diab Vasc Dis Res. 2016;13:303-6.

107. Xiao Zhang, Jian Jun Liu, Chee Fang Sum, Yeoh Lee Ying, Subramaniam Tavintharan,

Na Li, Chang Su, Serena Low, Simon BM Lee, Wern Ee Tang, Su Chi Lim. Ethnic

disparity in inter-arm systolic blood pressure difference among Asians with type 2

diabetes. Journal of the ASEAN Federation of Endocrine Societies (JAFES) 2016;31:81-

86

109. Jian-Jun Liu*, Sylvia Liu*, Melvin DS Wong, Resham Lal Gurung and Su Chi Lim.

Urinary haptoglobin level predicts rapid renal function decline independent of

albuminuria and traditional risk factors in Asians with type 2 diabetes mellitus and early

kidney disease. J Clin Endocrinol Metab 2016;101:3794-3802 *denotes equal

contribution.

110. Low SK, Khoo JK, Tavintharan S, Lim SC, Sum CF. Missed Appointments at a

Diabetes Centre: Not a Small Problem. Ann Acad Med Singapore. 2016;45:1-5.

111. Serena Low SK, Su Chi LIM, Lee Ying YEOH, Allen LIU, Xiao ZHANG, Tavintharan

Subramaniam, Chee Fang SUM. Development and Validation of a Predictive Model for

Chronic Kidney Disease Progression in Type 2 Diabetes Mellitus Based on a 13-year

study in Singapore Diabetes Research and Clinical Practice. Diabetes Res Clin Pract.

2016;123:49-54

112. Dennis C.C. Seow, Qi Gao, Philip Yap, Jia Min Gan, Hui Ling Chionh, Su Chi Lim, Lei

Feng, Tze Pin Ng. Profile of the Paraoxonase 1 (PON1) Gene 192Q/R Polymorphism and

Clinical Associations among Older Singaporean Chinese with Alzheimer’s and Mixed

Dementia. Dementia and Geriatric Cognitive Disorders Extra. 2016;6:43-54

113. Serena Low Kiat Mun; Sum Chee Fang; Subramaniam Tavintharan; Yeoh Lee Ying;

Allen Liu Yan Lun; Zhang Xiao; Liu Jianjun; Sharon Fun. Lim Su Chi. The effect of

long-term glycemic variability on estimated glomerular filtration rate decline among

patients with diabetes mellitus – insights from the Diabetic Nephropathy Cohort in

Singapore. Journal of Diabetes (in press) doi: 10.1111/1753-0407.12512

32

114. Ester CK Yeoh, Sum Chee Fang; Subramaniam Tavintharan; Yeoh Lee Ying ; Sharon

Fun; Julia Tong Chek Phoon; Lim Boon Khim, Lim Su Chi. Efficacy of self-monitoring

of blood glucose versus retrospective continuous glucose monitoring in improving

glycaemic control in diabetic kidney disease patients. Nephrology 2017 (in press)

115. Jian-Jun Liu, Sujoy Ghosh, Jean-Paul Kovalik, Jianhong Ching, Hyung Won Choi,

Subramaniam Tavintharan, Choon Nam Ong, Chee Fang Sum, Scott A Summers, E

Shyong Tai and Su Chi Lim. Profiling of plasma metabolites suggests altered

mitochondrial fuel usage and remodeling of sphingolipid metabolism in individuals with

type 2 diabetes and kidney disease. Kidney Int Rep (2017) 2, 470–480

116. Mei Chung Moh, Chee Fang Sum, Subramaniam Tavintharan, Keven Ang, Simon Biing

Ming Lee, Wern Ee Tang, Su Chi Lim. Baseline predictors of aortic stiffness progression

among multi-ethnic Asians with type 2 diabetes. Atherosclerosis2017;260:102-109.

117. Xiao Zhang, Serena Low, Chee Fang Sum, Subramaniam Tavintharan, Yeoh Lee Ying,

Jianjun Liu, Na Li, Simon BM Lee, Wern Ee Tang, Su Chi Lim. Arterial stiffness is an

independent predictor for albuminuria progression among Asians with type 2 diabetes – A

prospective cohort study. J Diabetes Complications 2017 doi:

10.1016/j.jdiacomp.2017.02.004 (in press)

118. Serena Low SL, Su Chi LIM. Effect of Sodium-Glucose Co-Transporter 2 Inhibitor on

an Obese Patient with Long-Standing Type 2 Diabetes and Solitary Kidney. Diabetes

Case Reports 2017 (in press).

119. Dorajoo Sreemanee Raaj*, Ng Shi Ling Joceline*, Goh Hui Fen Jessica, Lim Su Chi,

Yap Chun Wei, Chan Alexandre, Lee Yu Chia Joyce. HbA1c variability in type 2 diabetes

is associated with the occurrence of new-onset albuminuria within three years. Diabetes

Res Clin Pract. 2017;128:32–39

120. Yoong Hun Ong, Wei Choon Alvin Koh, Mei Li Ng, Su Chi Lim and Adult-Onset

Autoimmune Diabetes Mellitus Consortium (ADAMS), Bernhard Otto Boehm GAD- and

IA-2-antibody profiles in Subjects with Adult Onset Diabetes Mellitus: A Transethnic

Comparison between mixed ethnic population of Singaporean and Germans. Diab Med

2017 (in press)

121. Sharon Pek, Lee Ying Yeoh, Su Chi Lim, Chee Fang Sum, S Tavintharan. Association

of Apolipoprotein-CIII (apoC-III), endothelium-dependent vasodilation and Peripheral

Neuropathy in a multi-ethnic population with Type 2 Diabetes. Metabolism 2017 (in

press)

122., Joel LIM Guanyi, Su Fen ANG, Clara Tan SH, and Jessie Fong CW, Su Chi LIM

Cessation of Multiple Daily Insulin Injections in a Person with Twenty-Nine Years of

“Type 1 Diabetes”. Diabetes Case Report . Biomedical-Sci 17-094. 31st March 2017 (in

press).

33

123. Jian-Jun Liu, Sharon Li Ting Pek, Kevin Ang, Subramaniam Tavintharan and Su Chi

Lim. Plasma Leucine-rich Alpha-2-glycoprotein 1 Predicts Both Rapid eGFR Decline and

Albuminuria Progression in Type 2 Diabetes. J Clin Endocrinol Metab 2017 (in press).

34

Abstracts

1. A Enrique Caballero, Rola Saouaf, Subodh Arora, Su C Lim, Frank W. LoGerfo, Edward S

Horton, Aristidis Veves. Reactivity of the micro- and macro-circulation is impaired in

those at risk for type 2 diabetes. Diabetes 1998;47 (Suppl 1): A54

2. Lim SC, S Arora, AE Caballero, P Smakowski, ES Horton, FW LoGerfo, A Veves. The

influence of gender, menopausal status and hormonal replacement therapy on

microvascular reactivity in healthy and type 2 diabetic individuals. Diabetologia

1998;41:A55

3. Su C Lim, E S Tai, Edmund Chan, Boon S Chew, Sui S Goh, Chee E Tan. Singapore

General Hospital, Singapore. Soluble Intercellular Adhesion Molecules (ICAM) and

Vascular Cell Adhesion Molecules (VCAM) in Fenofibrate Treated Dyslipidemic Men

with Type 2 diabetes. Diabetes 1999;Vol. 48 (Suppl 1) A366.

4. . Lim SC, Caballero AE, Smakowski P, LoGerfo FW, Horton ES and Veves A. Impariment

in vascular reactivity and elevation of soluble intercellular adhesion molecule (ICAM) and

vascular cell adhesion molecule (VCAM) precede the development of microalbuminuria

and elevation of von Willebrand factor (vWF) in individuals with type 2 diabetes. Diabetes

1999 Vol.48 (Suppl 1) A142.

5. A Veves, AE Caballero, SC Lim, FW LoGerfo, ES Horton and A Zembowicz. Expression

of Endothelial Nitric oxide synthase (eNOS) in impaired glucose tolerance (IGT) and type

2 daibetes. Diabetologia 1999 Vol 42 Suppl 1 A76;273

6. Caballero AE, SC Lim, Smakowski P, LoGerfo FW, Horton ES and Veves A. Impaired

vascular reactivity and endothelial activation in type 2 diabetes with or without

microalbuminuria. Diabetologia 1999 Vol 42 Suppl 1 A76;274

6. Su C Lim*, Roland Chu, E S Tai, Chee E Tan. Relative Beta Cell Dysfunction is

Demonstrable in Non-diabetic South Indian Men compared to Malays and Chinese.

Diabetes 2000 Vol. 49 (Suppl 1) A185

7. Ken Gu, ES Tai, Su C Lim, Heok S Lim. Herbal Use is less reported, less consulted, and

found no effects for Singaporean with Diabetes. Diabetes 2000 Vol. 49 (Suppl 1) A387

8. H H Tan, S C Lim, H S Lim. Flat-Bush Diabetes in Asians. Diabetes 2000 Vol 49 (Suppl 2)

A350

9. Su-Chi Lim*, Bee-Yian Tan, Suok-Kai Chew, Chee-Eng Tan The relationship between

insulin resistance and cardiovascular risk factors in overweight/obese non-diabetic

individuals: the 1992 Singapore National Health Survey. Diabetes 50 (Suppl 2):A210;

2001

10. Enrique Caballero, Rola Saouaf, Su Chi Lim, Osama Hamdy, Colleen O’Connor, Frank

W. LoGerfo, Edward S. Horton, Aristidis Veves The effects of troglitazone on the

endothelial function in patients with early or late type 2 diabetes. Diabetes 2001;50 (Suppl

2):A149;

35

11. A FY Koh, H H Tan, S C Lim. Stimulated C-peptide combined with Glutamic Acid

Decarboxylase Antibodies gives a better yield in the Diagnosis of Type 1 Diabetes Mellitus

in Young Asian Subjects. Diabetes 2002; 51 (Suppl 2):A533

12. Su Chi Lim, Bee Lan Lee, Hwee Huan Tan, Trisse Goh, Margaret Ong, It Koon Tan,

Choon Nam Ong. Mitochondrial dysfunction in type 2 diabetes. Diabetes 2003;52 (Suppl

2) A471

13. Su C Lim, Choon N Ong, Hwee H Tan, Angela Koh, Margaret Ong, Trisse Goh, Chin L

Chua, Boon L Heng, Chee F Sum. Gender differences in the endothelial function of

Individuals with Type 2 Diabetes - the role of oxidative stress. Ann Acad of Med Sing

2003; 32 (Suppl) No.5:S91

14. Angela koh, Lim Su Chi, Ho Chee Khun, Trisse Goh, Chua Chin Lian, Theresa Ee, Sum

Chee Fang Aggressive Intervention Retards Progression of Nephropathy In Individuals

With Type 2 Diabetes Mellitus. Ann Acad of Med Sing 2003;32 (Suppl) No.5:S144

15. Angela Koh, Lim Su Chi, Ho Chee Khun, Trisse Goh, Chua Chin Lian, Theresa Ee, Sum

Chee Fang Angiotensin Receptor Blockers are Superior to Angiotensinogen Converting

Enzyme Inhibitors in Preserving Renal Function in Patients with Diabetic Nephropathy

from Type 2 Diabetes Mellitus. Ann Acad of Med Sing 2003;32 (Suppl) No.5:S89

16. Su-Chi Lim, Angela Koh, Trisse Goh, Chin-Lian Chua, Boon-Ling Heng, Chee-Fang

Sum. Losartan Versus Quinapril In Asian Subjects With Type 2 Diabetes And

Albuminuria – A Randomized Cross Over Study. Diabetes 2004 53 (Suppl 2) A135

17. Su Chi Lim, Hwee Huan Tan, Shirley Suresh, Chin Lian Chua, Trisse Goh, Boon Ling

Heng, Liang Shen, Angela Koh, Maria Lim, It Kun Tan, Chee Fang Sum. The effect of

high dose vitamin E on the endothelial function of Asian subjects with type 2 diabetes.

Diabetes 2004 53 (Suppl 2) A135

18 Angela Koh, Su Chi Lim, Trisse Goh, Yirong Lai, Chee Fang Sum. Endothelial Nitric

Oxide Synthase gene polymorphisms are not associated with Diabetic Nephropathy in

Singaporean Chinese – a preliminary report. Diabetes 2004 53 (Suppl 2) A503

19 Tavintharan S, SC Lim, A Koh, T Goh, CF Sum. Is response to statin therapy in type 2

DM affected by ApoE genotype? Diabetes 2004 53 (Suppl 2) A520

20. Su-Chi Lim, Angela Koh, Trisse Goh, Chin-Lian Chua, Boon-Ling Heng, Chee-Fang

Sum. Losartan Versus Quinapril In Asian Subjects With Type 2 Diabetes And

Albuminuria – A Randomized Cross Over Study. Ann Acad Med Sing 2004 33 (Suppl 5)

S105

21. SC Lim, WK Wee, T Subramaniam, A Koh, YR Lai, T Goh, MS Wong. The relationship

between NCEP defined metabolic syndrome and albuminuria in Asians Ann Acad Med

Sing 2004 33 (Suppl 5) S105

36

22. M Ta, BC Lim, HH Tan, E Chan, K Gu, SY Goh, S Liang, CE Tan, SC Lim.

Effectiveness of nurse clinician case manager and telemedicine in the management of

patients with persistently uncontrolled diabetes mellitus. Ann Acad of Med 2004 33 (Suppl

5) S163

23 Su C Lim, Choon N Ong, Trisse Goh, Tavintharan Subramaniam, Chee F Sum

Mitochondrial oxidative burden in pre-diabetic and diabetic individuals – indirect evidence

from plasma coenzyme Q10. Diabetes 2005; 54 (Suppl 1):A163

24 Su-Chi Lim, Trisse Goh, Chee-Fang Sum Renin-angiotensin System Blockade and

Tissue Growth Factor (TGF) in Asian Subjects With Type 2 Diabetes (T2DM) And

Albuminuria - A Randomized Cross Over Study. Diabetes 2005; 54 (Suppl 1):A113

25 AFY Koh, S Tavintharan T Goh, VCC Lim, XH SU, SC Lim, CF Sum.

Apolipoprotein E genotypes affect the response to statin therapy in Singaporean Chinese

patients with type 2 diabetes mellitus. Diabetes 2005; 54 (Suppl 1):A235

26 Chee Fang Sum, Su Chi Lim, Tavintharan Subramaniam, Yew Seng Wu, Trisse Goh,

Moh Sim Wong, Wei Keong Wee. Determinants of plasma adiponectin in Asian adults.

Diabetes 2005; 54 (Suppl 1):A2375

27 SC Lim, T Goh, YR Lai, WW Tee, A Koh, XH Xu, T Subramaniam, CF Sum

Relationship between common functional polymorphisms of the p22phox gene (-930A>G &

+242 C>T) and nephropathy due to type 2 diabetes among Chinese. Nephrology 2005;10

(Suppl) A8

28 Su Chi Lim, Vivien Lim, Rajmohan Narayan, Yew Seng Wu, Trisse Goh, Wei Keong

Wee, Moh Sim Wong, Tavintharan Subramaniam, Chee Fang Sum. Traditional and emerging

cardiovascular risk factors in microalbuminuric non-diabetic Asians. Nephrology 2005;10

(Suppl) A149

29 GOH Kian Peng, LIM Su Chi* YEOH Lee Ying**, Ramakrishnan Gopalakrishnan**,

Angela KOH, CHUA Chin Lian*, TAN Wan Ling*, Theresa EE, Trisse GOH, XU Xiao

Hong, Constance ONG, Tavintharan SUBRAMANIAM, SUM Chee Fang* .Long term

prospective follow up experience from a multi-disciplinary diabetes nephropathy clinic

(DNC) Nephrology 2005;10 (Suppl) A24.

30 TAVINTHARAN S, LIM SC, XU XH, SUM CF. Albuminuria predicts the risk of

peripheral artery disease In diabetes mellitus. Nephrology 2005;10 (suppl):A26.

31 TAVINTHARAN S, LIM SC, WEE WK, KOH A, GOH T, WU YS, WONG MS,

SUM CF. Metabolic syndrome and its association with biomarkers of inflammation and

metabolism Atherosclerosis. 2005;6(suppl 1)

32 Su Chi Lim, Tavintharan Subramaniam, Wei Keong Wee, Angela Koh, Yirong Lai,

Trisse Goh, Yew Seng Wu, Moh Sim Wong, Chee Fang Sum. Albuminuria is associated with

increased cardiovascular risk burden in non-diabetic Asians subjects. Atherosclerosis

2005;6(suppl 1)

37

33 TAVINTHARAN S, SIVAKUMAR M, LIM SC, SUM CF. Niacin in atherosclerosis:

does pleiotropism exist? Atherosclerosis. 2005;6 (suppl 1):123.

34 Su Chi Lim, Tavintharan Subramaniam, Yew Seng Wu, Trisse Goh, Moh Sim Wong, Wei

Keong Wee, Chee Fang Sum Adiponectin gene polymorphisms and type 2 diabetes in

Chinese. Ann Acad Med Sing; 34 (suppl) S22. 2005. (Best oral award finalist)

34 Vivien CC LIM, SC LIM, LY YEOH, YM LEE, Pearl LEE, Jaclyn Ong, BH TEY, T

SUBRAMANIAM, Edwin SY CHAN, SUM Chee Fang. Lactate Levels in Asian Patients

with Type 2 Diabetes Mellitus on Metformin and Its Association with Dose of Metformin and

Renal Function. Diabetes 2006 (Suppl)

35 GAN Jia Min, YEOH Lee Ying, CHIONH Chang Yin, Trisse GOH, TOY Wan Ching,

Tavintharan Subramaniam, SUM Chee Fang, LIM Su Chi. Adrenomedullin receptor gene

promoter haplotype is associated with elevated plasma adrenomedullin protein concentration

and nephropathy secondary to type 2 diabetes. Ann Acad Med Sing 2007:36(suppl):S52

36 WC TOY, T SUBRAMANIAM, YS WU, SK GOH, JM GAN, CF SUM, SC LIM. Allele

specific differential expression of type 2 diabetes candidate gene - adiponectin +45T>G

(rs2241766) SNP - using 3T3-L1 cell line. Ann Acad Med Sing 2007:36(suppl):S13

37 Vikram Sonawane, Lim Su Chi, Tavintharan Subramaniam, Trisse Goh, Wong Moh Sim,

Sum Chee Fang. NCEP defined metabolic syndrome is associated with increased risk for

microalbuminuria in Asians. Ann Acad Med Sing 2007:36(suppl):S14

38 A. Armugam, S.Tavintharan, DS Karolina, SC. Lim, CF Sum and K. Jeyaseelan

microRNA profiling in patients with impaired fasting glucose. Ann Acad Med Sing 2008

39 Su Chi Lim, Jian Jun Liu, Hui Qi Low, Lee Ying Yeoh, Tavintharan Subramaniam, Chee

Fang Sum, Kee Seng Chia Microarray analysis of multiple candidate genes and associated

plasma proteins for nephropathy secondary to type 2 diabetes among Chinese. Ann Acad Med

Sing 37(suppl):S71. 2008

40 Su Chi Lim, Jian Jun Liu, Nils G. Morgenthaler, Jia Min Gan, Siew Kheng Goh, Wan

Ching Toy, Kee Seng Chia. Deep re-sequencing of adrenomedullin and drenomedullin

receptor genes revealed possible association with plasma mid-region proadrenomedullin

concentrations and diabetic nephropathy. Ann Acad Med Sing 37(suppl):S81. 2008

41 Trisse Goh, JM Gan, Cherine Tan, Arunmozhiarasi Armugam, Sum Chee Fang,

Tavintharan Subramaniam, Kandiah Jeyaseelan, Lim Su Chi Molecular epidemiology in

nephropathy secondary to type 2 diabetes. Ann Acad Med Sing 37(suppl):S12. 2008 (Short-

listed as 1 of the 3 finalists in best posters presentation).

42 WC TOY, R NARAYANAN, A CHENG, JM GAN, TJ TAN, T SUBRAMANIAM, SC

LIM. Visceral and subcutaneous adipocytes from obese Asian subjects showed differential

inflammatory cytokines and receptors gene expression. Ann Acad Med Sing 37(suppl):S45.

2008

38

43 JM Gan, DP Lau, LY Yeoh, WC Toy, DL Quek, XC Dong, ML Tioh, YY Tang, S

Tavintharan, CF Sum, SC Lim. Genetic polymorphisms of Calcitonin Like Receptor (CLR)

for Adrenomedullin and diabetic nephropathy secondary to type 2 diabetes. Ann Acad Med

Sing 38(suppl):S82. 2009.

44 DL QUEK, LY YEOH, Y QIN, WC TOY, DP LAU, JM GAN, C TAN, MLC TIOH, YY

TANG, XC DONG, CF SUM, T SUBRAMANIAM, SC LIM. Urinary Proteomes in Non-

albuminuric Diabetic Nephropathy Patients. Ann Acad Med Sing 38(suppl):S76. 2009

45 N JAUHAR, T SUBRAMANIAM, A OMAR, TC LIM, MS WONG, CF SUM, SC LIM

The Associations between low-HDL Cholesterol, Adiponectin and Cardiovascular Risk

Factors – Results From a Cross-sectional Study in Female Healthcare Workers. Ann Acad

Med Sing 38(suppl):S4. 2009

46 Setyowati KD, Arunmozhiarasi A, Tavintharan S, Michael W, Chun TE, Lim SC, CF

Sum, Kandia J. MicroRNAs: Potential therapeutic targets for metabolic syndrome, a predictor

of fatty liver. Clinical and Experimental Medical Journal 2009 (Suppl) page 624

47 Zainudin S1, Phua EJ1, Lim SC1, Subramaniam T1, Sum CF1, Tan LK2.How would the

new diagnostic criteria for Gestational Diabetes Mellitus affect us? Singapore Med J

2011:52(1 Suppl) S16

48 Eng Joo Phua1, Sharon Fun2, Sueziani Zainudin1, Lee Ying Yeoh1, Chay Mien Lim3,

Tavintharan Subramaniam1, Su Chi Lim1, Chee Fang Sum1 Risk Factors Associated with

Arterial Stiffness in Type 2 Diabetes Mellitus Singapore Med J 2011:52(1 Suppl) S18

49 Ester CK Yeoh1, S Zainudin1, SC Lim1, S Tavintharan1, CL Chua2, S Fun2, CF Sum1

The Effect of Fasting during the Month of Ramadan on Body Composition and Glycaemic

Control in Muslim Type 2 Diabetes Individuals. Singapore Med J 2011:52(1 Suppl) S19

50 Fun Sharon Nne1, Yeoh Lee Ying2, Lim Eng Kuang2, Terina Seow2, Melvin Wong3, Lim

Chay Mien3, Dong Xiu Chun3, Lim Boon Khim3, Ruth Chia Kui Un3, Norhayati Binte

Zakari3, Liew Yiting3, Sun Jing1, Sumathi Govidan1, Tavintharan Subramaniam2, Sum

Chee Fang2, Lim Su Chi2 . Predictors of progression of moderately advance diabetic

nephropathy secondary to type 2 diabetes. Singapore Med J 2011:52(1 Suppl) S38

51 Lim SC, Quek DL, Toy WC, Wong DSM, Yeoh LY, Tan CMF, Lau PXD, Tan SHC,

Tavintharan S, Sum CF. Validation of adipocytokine zinc alpha-2 glucoprotein as novel

urinary biomarker for normoalbuminuria diabetic nephropathy using western blot analysis.

Singapore Med J 2011:52(1 Suppl) S56

52 Tan SHC, Toy WC, Lau PXD, Wong DSM, Lim CM, Chia RKU, Sum CF, Tavintharan S,

Lim SC. Association of MYH9 gene with diabetic nephropathy secondary to type 2 diabetes

mellitus among Singaporean Chinese. Singapore Med J. 2011;52 (1 Suppl): S56-57.

53 Lau PXD, Toy WC , Cheng A, Tan SHC, Wong DSM, Narayanan R, Sum CF,

Tavintharan S, Lim SC. Differential gene expression of angiogenic factors between human

visceral and subcutaneous adipose tissue. Singapore Med J. 2011;52 (1 Suppl): S57.

39

54 Wong DSM, Toy WC, Pek LS, Lim CM, Soh D, Zakaria NB, Chia R, Yeoh LY, Tan C,

Lau PXD, Tan SHC, Tavintharan S, Sum CF, Lim SC. Urinary proteomics associated with

progressive diabetic nephropathy secondary to type 2 diabetes mellitus. Singapore Med J.

2011;52 (1 Suppl): S62.

55 Lau PXD, Toy WC, Cheng A, Tan SHC, Wong DSM, Narayanan R, Sum CF, Tavintharan

S, Lim SC. Differential gene expression of inflammatory cytokines and receptors between

human visceral and subcutaneous adipose tissue. Singapore Med J. 2011; 52 (1 Suppl): S63.

56 Toy WC, Cheng KSA, Tan JJ, Lau PXD, Tan SHC, Wong DSM, Tavintharan S, Sum CF,

Lim SC. Effect of rosiglitazone on subcutaneous versus visceral adipocytes on miRNA

profiling. Singapore Med J. 2011; 52 (1 Suppl): S63-64.

57 CLARA TAN, ENG JOO PHUA, WAN CHING TOY, JIAN JUN LIU, DAWN LAU,

MELVIN WONG, AMIZAH B. ASRAP, LEE YING YEOH, ADRIAN LIEW,

TAVINTHARAN SUBRAMANIAM, CHEE FANG SUM, SU CHI LIM, Association of

Neutral Endopeptidase With Diabetic Nephropathy in Type 2 Diabetes among Singaporean

Chinese. Diabetes. 61 (Supplement 1) A670

58 Yeoh Lee Ying, Tavintharn Subramaniam, Sum Chee Fang, Ng Xiao Wei, Lim Su

ChiAlbuminuria and Arterial Stiffness in Type 2 Diabetics with Well-Preserved Renal

Function. American Journal of Nephrology 2012.

59 Ng XW, Lim SC, Subramaniam T, Yeoh LY, Asrap A, Cheok J, Ou Y, Arof M, Lum NJ,

Riffin N, Sum CF. Clinical predictors of established diabetic nephropathy in a large Asian

population. Singapore Med J. 2012; 53 (1 Suppl): S25.

60 Tan SHC, Toy WC, Liu JJ, Wong DSM, Asrap AB, Yeoh LY, Liew A, Subramaniam T,

Sum CF, Lim SC. Association of neutral endopeptidase (NEP) with diabetic nephropathy

secondary to type 2 diabetes mellitus in Singaporean Chinese patients. Singapore Med J.

2012; 53 (1 Suppl): S35.

61 Wong DSM, Liu JJ, Toy WC, Tan CSH, Sylvia, Tavintharan S, Sum CF, Lim SC. The

association of myokine irison with type 2 diabetes mellitus. Singapore Med J. 2012; 53 (1

Suppl): S36-37.

62 Liu JJ, Lim SC, Subramaniam T, Sum CF. Angiotensin II receptor I blocker, losartan, but

not angiotensin-converting enzyme inhibitor, quinapril, increases circulating α-klotho in

individuals with type 2 diabetes mellitus and albuminuria. Singapore Med J. 2012;53 (1

Suppl): S62-63.

63 Slyvia, Liu JJ, Toy WC, Tan CSH, Wong MDS, Lim SC, Subramaniam T, Sum CF.

Circulating undercarboxylated osteocalcin correlates with body composition in patients with

type 2 diabetes mellitus. Singapore Med J. 2012;53 (1 Suppl): S70.

64 Lin L, Pek LTS, Woon K, Liew Y, Dong X, Lee CM, Lim SC, Sum CF, Tavintharan S.

Safety of simvastatin for patients with hypercholesterolemia and fatty liver. Singapore Med J.

2012; 53 (1 Suppl): S23

40

65 Pek LTS, Woon K, Lin L, Lim BK, Lim SC, Sum CF, Tavintharan S. Differential

microRNA expression profiles are associated with diabetes mellitus and body mass index.

Singapore Med J. 2012; 53 (1 Suppl): S26

66 Woon K, Pek LTS, Lin L, Niyati J, Tavintharan S. Association between pigment

epithelium-derived factor (PEDF) and apolipoprotein A-1 (ApoA1) expression using cell

culture model. Singapore Med J. 2012; 53 (1 Suppl): S36

67 Woon K, Sylvia, Nur Afiqah MA, Pek LTS, Lin L, Tavintharan S, Lim SC, Sum CF.

Prevalence of pigment epithelium-derived factor gene polymorphisms in Singapore Chinese

patients with abnormal fasting glucose. Singapore Med J. 2012; 53 (1 Suppl): S65

68 Lin L, Lee BL, Ong CN, Pek LTS, Woon K, Liew Y, Dong X, Lim SC, Sum CF,

Tavintharan S. Association of lutein and zeaxanthin with statin in patients with

hypercholesterolaemia. Singapore Med J. 2012; 53 (1 Suppl): S66

69 C. S. H. Tan, L. Y. Yeoh, X. W. Ng, W. C. Toy, J. J. Liu, M. D. S. Wong, S. Liu, A. B.

Asrap, T. Subramaniam, C. F. Sum, S. C. Lim. Association between rare variant in the

receptor for adrenomedullin and diabetic nephropathy secondary to type 2 diabetes

(HGM2013-ICG-1179) Joint Conference of HMG 2013 and 21st International Congress of

Genetics. Genetics and Genomics of Global Health and Sustainability. 13-18 Apr 2013 The

Sands Expo and Convention Center, Marina Bay Sands

70 C. S. H. Tan, C. L. Leaw, X. W. Ng, Y. M. Bee, A. Carrera, E. C. K. Yeoh, W. C. Toy, J.

J. Liu, M. D. S. Wong, S. Liu, A. Ou Yao, T. Subramaniam, C.F. Sum, S. C. Lim. Sanger’s

sequencing and bench-top next generation sequencing (ngs) revealed a novel mutation

(h126d) in hepatocyte nuclear factor-1α (hnf-1a) gene associated with maturity onset diabetes

of the young type 3 (mody3) (HGM2013-ICG-1185) Joint Conference of HMG 2013 and 21st

International Congress of Genetics. Genetics and Genomics of Global Health and

Sustainability. 13-18 Apr 2013 The Sands Expo and Convention Center, Marina Bay Sands

71 C. S. H. Tan, W.H. Toh, X. W. Ng, Y. M. Bee, A. G Hii. C. K. Yeoh, W. C. Toy, J. J. Liu,

M. D. S. Wong, S. Liu, A. Ou Yao, T. Subramaniam, C.F. Sum, S. C. Lim. Validation of a

novel mutation (h126d) in hepatocyte nuclear factor-1α (hnf-1a) gene associated with

maturity onset diabetes of the young type 3 (mody3) using the personal genome machine

(pgm) (HGM2013-ICG-1566) Joint Conference of HMG 2013 and 21st International

Congress of Genetics. Genetics and Genomics of Global Health and Sustainability. 13-18 Apr

2013 The Sands Expo and Convention Center, Marina Bay Sands

72 Ester YEOH, Sueziani ZAINUDIN, Win Nie LOH, Chin Lian CHUA, Sharon FUN,

Tavintharan SUBRAMANIAM, Chee Fang SUM, Su Chi LIM. Iso-caloric intake during

Ramadan-fasting leads to improvement in HbA1c and beneficial changes in body

composition among individuals with type 2 diabetes. The American Diabetes Association's

73rd

Scientific Sessions June 21-25, 2013

73 Jian-Jun Liu, Lee Ying Yeoh, Tavintharan Subramaniam, Chee Fang Sum, Ester Yeoh*,

Xiao Wei Ng, Wan Ching Toy, Sharon Pek, Su Chi Lim. Soluble receptor for advanced

glycation end products (sRAGE) is associated with arterial stiffness only in type 2 diabetes

41

with normal albuminuria. The American Diabetes Association's 73rd

Scientific Sessions June

21-25, 2013

74 Su Chi LIM, Melvin WONG, Wan Ching TOY, Angela MOH, Lee Ying YEOH, Dawn

LAU, Clara TAN, Tavintharan SUBRAMANIAM, Chee Fang SUM. 2nd

NKF Annual

Scientific Meeting 22nd

March 2014, Singapore.

75. Ang S F, Lim S C, Li Y, Tan S H C, Wong D S M, Yeoh L Y , Liew A, Tavintharan S,

Sum C F, Liu J J. Genome-wide association study using ethnic-specific exome-centric

nonsynonymous rare-variant microarray for diabetic nephropathy secondary to Type 2

diabetes. Singapore Med J 2014; 55(1 Suppl): S27

76. Liu Jian-Jun, Lim SC, Yeoh LY, Su C, Low KMS, Aswin B, Chia A, Fun S, Tavintharan

S and Sum CF. A prospective study of ethnic disparity in cardiovascular outcomes among

Asians with type 2 diabetes. Singapore Med J 2014; 55(1 Suppl): S29

77. Moh Mei Chung, Yeoh Li Ying, Sum Chee Fang, Ng Xiao Wei, Tavintharan

Subramaniam, Melvin Wong Ding Sheng, Lim Su Chi Association of central obesity with

renal function in early-onset type 2 diabetes. . Singapore Med J 2014; 55(1 Suppl): S29

78. Ang SF, Hoi Q, Tan HH, Fong CWJ, Tan SHC, Sylvia, Gurung RL, Lim SC. Genomic

medicine in diabetes – Whole Exome Sequencing (WES) as a tool for identifying novel

genetic variants responsible for monogenic diabetes in a pedigree study. Singapore Med J

2016: 57(1 suppl) S29

79. Goenadi CJ, Zhang X, Pek S, Tavintharan S, Sum CF, Lim SC, Yip CC, Neelam K.

Elevated plasma leucine-rich alpha 2 glycoprotein 1 is associated with diabetic nephropathy

in Asians with type 2 diabetes mellitus. Singapore Med J 2016: 57(1 suppl) S29.

80. Tan LT, Cheng KS, Lim SC. Roux-en-Y Gastric Bypass vs. Best Medical Treatment for

type 2 Diabetes with BMI 27 to 32- Preliminary result of a Randomised Controlled Trial.

Singapore Med J 2016: 57(1 suppl) S30.

81. Low KMS, Lim SC, Zhang X, Yeoh LY, Liu YL, Tavintharan S, Sum CF. Navigating

through the Paradigm of Chronic Kidney Disease in Type 2 Diabetes ? Useful Lessons and

Prediction Model Based on a 13-Year Prospective Cohort Study. Singapore Med J 2016: 57(1

suppl) S31.

82. Wong DSM. Moh MC, Lim SC. Association of urinary progranulin with albuminuria in

Chinese patients with type 2 diabetes. Page 28 Proceedings of OBES (Obesity | Bariatric |

Endocrine | Study of Obesity) Scientific Meeting 18-19 Nov 2016 Mandarin Orchard

Singapore.

83. Moh MC, Cheng A, Lim SC. Fractalkine – regulation in human visceral adipose tissue

and association with type 2 diabetes. Page 34 Proceedings of OBES (Obesity | Bariatric |

Endocrine | Study of Obesity) Scientific Meeting 18-19 Nov 2016 Mandarin Orchard

Singapore.

42

Low SKM, Lim SC, Zhang X, Subramaniam T, Sum CF. Study on association between renal

hyperfiltration and rapid renal decline in Type 2 Diabetes. Proceedings of the American

Diabetes Association’s 77th

Scientific Sessions, American Diabetes Association, United

States. Diabetes 2017; 66 (Suppl 1).

Pre-diabetes in East Asians is Associated Specifically with Defects in Glucose Homeostasis,

but Not with Other Cardio-metabolic Risk Factors. ADA 2017

43

Poster/Oral Presentations:

Lim SC, Fok ACK, Ong YY. Patients outcome and intensive care resource allocation using

APACHE II. Oral presentation, 6th

Annual Scientific Meeting Singapore General Hospital,

April 1995.

Lim SC, Pillay P, Khoo D, Tan CE, Eng P, Ho SC. A case of pleuri-potent pituitary

macroadenoma. Presented as poster at the 10th International Congress of Endocrinology,

San Francisco, CA, June 1996; and 7th Singapore General Hospital Annual Scientific

Meeting, May 1996.

Lim SC, Eng P, Khoo D, Tan CE, Koh LKH, Fok ACK. Evaluation of two modes of capillary

blood glucose monitoring. Presented as poster in the Singapore General Hospital Seventh

Annual Scientific Meeting May 1996.

Eng P, Lim SC, Khoo D, Tan CE, Koh LKH, Fok ACK. Insulin response and glycemic index

of an enteric formula designed for patient with impaired glucose tolerance. Presented as

Poster in 8th ASEAN Federation of Endocrine Societies in Philippines, September 1995.

Lim SC, Lim HS, Khoo D, Tan CE, Koh LKH, Ho SC, Eng P, Tai ES, Fok ACK. Secondary

hyperthyroidism - A review of an uncommon cause of thyrotoxicosis. Presented as poster in

the 8th

Singapore General Hospital Annual Scientific Meeting.

A Enrique Caballero, Rola Saouaf, Subodh Arora, Su C Lim, Frank W. LoGerfo, Edward S

Horton, Aristidis Veves. Reactivity of the micro- and macro-circulation is impaired in those

at risk for type 2 diabetes. American Diabetes Association Annual Scientific Meeting June

1998.

Lim SC, S Arora, AE Caballero, P Smakowski, ES Horton, FW LoGerfo, A Veves. The

influence of gender, menopausal status and hormonal replacement therapy on microvascular

reactivity in healthy and type 2 diabetic individuals. European Association for the Study of

Diabetes, Barcelona, Spain. Sept. 1998.

Lim SC, Caballero AE, Smakowski P, LoGerfo FW, Horton ES and Veves A. Impariment in

vascular reactivity and elevation of soluble intercellular adhesion molecule (ICAM) and

vascular cell adhesion molecule (VCAM) precede the development of microalbuminuria and

elevation of von Willebrand factor (vWF) in individuals with type 2 diabetes. Joslin Diabetes

Center 100th

Anniversary celebration conference: Diabetes Complications conference.

Boston, USA. Oct. 98

Su C Lim, Daphne Khoo, Chee E Tan, Leonard Koh, Peter Eng, Su C Ho, E S Tai, Heok S

Lim, Alex Fok. Department of Endocrinology. Study of Biochemical Bone Markers in

Hypercalcemic and Normocalcemic Thyrotoxic Patients. Oral presentation, 10th

Annual

Scientific Meeting Singapore General Hospital, 24 April 1999.

Lim SC, Caballero AE, Smakowski P, LoGerfo FW, Horton ES and Veves A. Impariment in

vascular reactivity and elevation of soluble intercellular adhesion molecule (ICAM) and

vascular cell adhesion molecule (VCAM) precede the development of microalbuminuria and

44

elevation of von Willebrand factor (vWF) in individuals with type 2 diabetes. Poster

presentation. American Diabetes Association Annual Scientific Meeting 1999, San Diego.

A Veves AE Caballero, SC Lim, FW LoGerfo, ES Horton and A Zembowicz. Expression of

endothelial nitric oxide synthase (eNOS) in impaired glucose tolerance (IGT) and type 2 DM.

American Diabetes Association Annual Scientific Meeting 1999, San Diego.

Tan Hwee Huan, Su C Lim, Tai E Shyong, Leong Hoe Nam, Lim Heok Seng. Department of

Endocrinology. Accuracy of glucometers: analysis of statistics. Poster presentation, 10th

Annual Scientific Meeting Singapore General Hospital, 23-24 April 1999.

Ho Su Chin, Eng PHK, Tai ES, Lim SC, Loh LM, Tan HH, Koh LKH, Tan CE, Lim HS, Fok

ACK, Khoo DHC. The predictive value of TSH-receptor antibodies in determining Grave’s

disease outcome after medical therapy. Oral presentation, 10th

Annual Scientific Meeting

Singapore General Hospital, 24 April 1999.

HH Tan, SC Lim, HS Lim, ASA Tan, D Ong, M Yeo, LM Loh, ES Tai, SC Ho, P Eng, L

Koh, CE Tan DHC Khoo and ACK Fok. Gestational Diabetes Mellitus: non-responsers to

post-partum OGTT - A need for systematic tracing. Fourth West Pacific Internal Diabetes

Federation (WP IDF) Scientific Meeting. Sept 1999 (accepted)

A Veves, AE Caballero, SC Lim, FW LoGerfo, ES Horton and A Zembowicz. Harvard

Medical School, Boston, MA, USA. expression of Endothelial Nitric oxide syntase (eNOS) in

impaired glucose tolerance (IGT) and type 2 daibetes. Oral presentation in 35th

European

Association for the Study of Diabetes (EASD) Annual scientific meeting Sept 1999, Belgium.

Su C Lim*, Roland Chu, E S Tai, Chee E Tan. Relative Beta Cell Dysfunction is

Demonstrable in Non-diabetic South Indian Men compared to Malays and Chinese. 60th

American Diabetes Association Scientific Meeting, San Antonio, USA, 2000

Lim Su Chi, Tan Hwee Huan, Margaret Ong, Allen Ng, Devendra, Ann Tan, Tan Hak Koon,

Lim Heok Seng. Fasting plasma glucose and 75g glucose challenge test as screening methods

for gestational diabetes. 12th

Annual Scientific Meeting, Singapore General Hospital, 27-28

April 2001

LIM Su Chi, HO Chee Khun, Angela KOH, Trisse GOH, CHUA Chin Lian, Theresa EE,

SUM Chee Fang. Preliminary experience from a joint nephrologist-endocrinologist diabetes

nephropathy management clinic – a call to meet the patients “upstream”. National Health

Group 1st Scientific Congress, Grand Copthorne Waterfront Hotel 17-18

th Aug 2002.

A FY Koh, H H Tan, S C Lim. Stimulated C-peptide combined with Glutamic Acid

Decarboxylase Antibodies gives a better yield in the Diagnosis of Type 1 Diabetes Mellitus in

Young Asian Subjects National Health Group 1st Scientific Congress, Grand Copthorne

Waterfront Hotel 17-18th

Aug 2002

Su-Chi Lim, Hwee- Huan Tan, Margaret Ong, Bee- Lan Lee, Choon-Nam Ong Diabetes

Mellitus: Is Coenzyme Q10 playing a role? The third conference of the international

Coenzyme Q10 Association 22-24 Nov 2002, London

45

Sock-Hoon Ng, Trisse Goh, Angela Koh, Yik-Ying Teo, Chee-Fang Sum, Su-Chi Lim, Eric

Yap A preliminary study of inducible nitric oxide synthase single nucleotide polymorphism in

diabetic nephropathy in type 2 diabetes mellitus. Fourth Combined Scientific Meeting 15-18

Jan 03 Clinical Research Centre, National University of Singapore. Integrating

Multidimensional Perspectives by Biomedical Research & Experimental Therapeutics Society

of Singapore (BRETSS).

YR Lai, A Koh, SC Lim. Comparison of Cockcroft-Gault equation and modification of diet

in renal disease study equation for glomerular filtration rate estimation in patients with

diabetes. Asean Federal Endocrine Society (AFES) 2003, Singapore.

YR Lai, A Koh, T Goh, SC Lim, CF Sum. Risk of Nephropathy due to type 2 diabetes among

Chinese is associated with a common variant of the endothelial nitric oxide synthase gene

(Glu298Asp) – a preliminary report. Asean Federal Endocrine Society (AFES) 2003,

Singapore.

Su Chi LIM, Angela KOH, Trisse GOH, Margaret ONG, Yirong LAI, Chee Eng TAN.

Relative Beta Cell Dysfunction is Demonstrable in Non-diabetic South Indian & Malay Men

compared to Chinese. Asean Federal Endocrine Society (AFES) 2003, Singapore.

Su-Chi Lim, Angela Koh, Trisse Goh, Chin-Lian Chua, Boon-Ling Heng, Chee-Fang Sum.

Losartan Versus Quinapril In Asian Subjects With Type 2 Diabetes And Albuminuria – A

Randomized Cross Over Study. American Diabetes Association 64th


4-8, 2004. Orlando, Florida

Su Chi Lim, Hwee Huan Tan, Shirley Suresh, Chin Lian Chua, Trisse Goh, Boon Ling Heng,

Liang Shen, Angela Koh, Maria Lim, It Kun Tan, Chee Fang Sum. The effect of high dose

vitamin E on the endothelial function of Asian subjects with type 2 diabetes. American

Diabetes Association 64th

Scientific Sessions June 4-8, 2004. Orlando, Florida

SC Lim, YR Lai, T Goh, A Koh, XH Xu, WW Tee, T Subramaniam, CF Sum, E Yap.

Relationship between a common functional polymorphism of the p22phox promoter (-

930A>G) gene and nephropathy due to type 2 diabetes among Chinese. 5th

Human Genome

Organization (HUGO) Pacific Meeting & 6th

Asia-Pacific Conference on Human Genetics.

17-20 November 2004, Biopolis, Singapore.

YR Lai, A Koh, T Goh, XH Xu, CF Sum, SC Lim Association between Common

Polymorphisms of Endothelial Nitric Oxide Synthase Gene and Overt Diabetic Nephropathy

in Chinese with Type 2 Diabetes. 5th

Human Genome Organization (HUGO) Pacific Meeting

& 6th

Asia-Pacific Conference on Human Genetics. 17-20 November 2004, Biopolis,

Singapore.

Su Chi Lim, Tavintharan Subramaniam, Wei Keong Wee, Angela Koh, Yirong Lai, Trisse

Goh, Yew Seng Wu, Moh Sim Wong, Chee Fang Sum. Albuminuria is associated with

increased cardiovascular risk burden in non-diabetic Asians subjects 75th

European

Atherosclerosis Society Congress 23-26 April 2005. Prague, Czech Republic.

46

Su C Lim, Choon N Ong, Trisse Goh, Tavintharan Subramaniam, Chee F Sum

Mitochondrial oxidative burden in pre-diabetic and diabetic individuals – indirect evidence

from plasma coenzyme Q10. American Diabetes Association 65th


10-14, 2005. San Diego, California.

Su-Chi Lim, Trisse Goh, Chee-Fang Sum Renin-angiotensin System Blockade and Tissue

Growth Factor (TGF) in Asian Subjects With Type 2 Diabetes (T2DM) And Albuminuria

- A Randomized Cross Over Study. American Diabetes Association 65th

Scientific Sessions

June 10-14, 2005. San Diego, California.

AFY Koh, S Tavintharan T Goh, VCC Lim, XH SU, SC Lim, CF Sum. Apolipoprotein E

genotypes affect the response to statin therapy in Singaporean Chinese patients with type 2

diabetes mellitus. American Diabetes Association 65th

Scientific Sessions June 10-14, 2005.

San Diego, California.

Chee Fang Sum, Su Chi Lim, Tavintharan Subramaniam, Yew Seng Wu, Trisse Goh, Moh

Sim Wong, Wei Keong Wee. Determinants of plasma adiponectin in Asian adults. American

Diabetes Association 65th

Scientific Sessions June 10-14, 2005. San Diego, California.

SC Lim, T Goh, YR Lai, WW Tee, A Koh, XH Xu, T Subramaniam, CF Sum Relationship

between common functional polymorphisms of the p22phox gene (-930A>G & +242 C>T)

and nephropathy due to type 2 diabetes among Chinese. World Congress of Nephrology, June

2005, Singapore.

Su Chi Lim, Vivien Lim, Rajmohan Narayan, Yew Seng Wu, Trisse Goh, Wei Keong Wee,

Moh Sim Wong, Tavintharan Subramaniam, Chee Fang Sum. Traditional and emerging

cardiovascular risk factors in microalbuminuric non-diabetic Asians World Congress of

Nephrology, June 2005, Singapore.

Goh Kian Peng, Lim Su Chi, Yeoh Lee Ying, Ramakrishnan Gopalakrishnan, Angela Koh,

Chua Chin Lian, Tan Wan Ling, Theresa Ee, Trisse Goh, Xu Xiao Hong, Constance Ong,

Tavintharan Subramaniam, Sum Chee Fang. Long term prospective follow up experience

from a multi-disciplinary diabetes nephropathy clinic (DNC) (DNC) World Congress of

Nephrology, June 2005, Singapore.

LC LIM1, CF SUM1, A KOH1, AHY CHIN2, SC LIM1, RC RAJASOORYA1 Clinical

Utility Of Repeat Fine Needle Aspiration Under Ultrasound Guidance In Patients With

Thyroid Nodules. Combined Scientific Meeting 4-6 Nov 2005.

Su Chi Lim, Tavintharan Subramaniam, Yew Seng Wu, Trisse Goh, Moh Sim Wong, Wei

Keong Wee, Chee Fang Sum. Adiponectin gene polymorphisms and type 2 diabetes in

Chinese. Combined Scientific Meeting 4-6 Nov 2005.

47

Pearl Tong, Su Chi Lim, Tavintharan Subramaniam, Yew Seng Wu, Trisse Goh, Moh Sim

Wong, Wei Keong Wee, Chee Fang Sum. Cardiovascular risk profile of Asian subjects with

impaired fasting glucose according to the new diagnostic criteria proposed by the American

Diabetes Association (ADA). Combined Scientific Meeting 4-6 Nov 2005 [awarded the Best

Poster (Med/Paeds)].

C Sabanayagam1, A Shankar, KS Chia, D Koh, SM Saw, ES Tai, Su Chi Lim, TY Wong,

Prevalence and Risk factors associated with chronic kidney disease in Singapore. WONCA

2007

W Toy; L Lau; L Rajmohan; C Tan; M Wong; C Sum; S Lim; T Subramaniam; T Tan; C

Anton The Effect of PPARg agonist Rosiglitazone on the gene Expression profile of

Subcutaneous vs Visceral Adipocytes. April 28, 2010. Developmental Origins and Epigenesis

in Human Health and Disease. Keystone Symposia

Toy WC ,Tan JJ, Lau P Dawn, Tan SH Clara, Wong DS Melvin, Subramaniam T, Sum CF,

Lim SC, Cheng KS Anton. The miRNA profiling on the Effect of Rosiglitazone on

Subcutaneous vs Visceral Adipocytes. Asia-Pacific Metabolic and Bariatric Surgery Society.

21st Oct 2010. Biopolis, The Matrix Building, Level 2. 30 Biopolis Street. Singapore 138671

Eng Joo Phua1, Sharon Fun

2, Sueziani Zainudin

1, Lee Ying Yeoh

1, Chay Mien Lim

3,

Tavintharan Subramaniam1, Su Chi Lim

1, Chee Fang Sum

1 Risk Factors Associated with

Arterial Stiffness in Type 2 Diabetes Mellitus. Poster Presentation. Asia Oceania Congress of

Endocrinology Kuala Lumpur 3-5 Dec 2010.

Zainudin S1, Phua EJ

1, Lim SC

1, Subramaniam T

1, Sum CF

1, Tan LK

2. How would the new

diagnostic criteria for Gestational Diabetes Mellitus affect us? Oral Presentation. Asia

Oceania Congress of Endocrinology Kuala Lumpur 3-5 Dec 2010.

Ng Hooi Ling, Dorithy Tay, Lim Su Chi Efficient Safety Reporting Tracking System at Khoo

Teck Puat Hospital (KTPH). Poster Presentation, 2nd

Asia Pacific Research Ethics

Conference, 9th

& 10th

March 2012 GrandCorpthorne Hotel, Singapore.

Wendy Sim, Ng Hooi Ling, Dorithy Tay, Darrick Toh, Lim Su Chi Study Monitoring by

Clinical Research Unit on Investigator Initiated Studies in Khoo Teck Puat Hospital. Poster

Presentation. 2nd

Asia Pacific Research Ethics Conference, 9th

& 10th

March 2012

GrandCorpthorne Hotel, Singapore.

Liew Yiting, Lim Boon Khim,, Amizah Asrap, Jisha John, Dong Xiu Chun, Jerlyn Cheok,

Amy Ou, Mawarni Arof, Tavintharan S. Lim Su Chi, A Survey to Identify the Factors

Affecting the Participants’ Willingness to Participate in Clinical Research Trial in Khoo Teck

Puat Hospital. Poster Presentation. 2nd

Asia Pacific Research Ethics Conference, 9th

& 10th

March 2012 GrandCorpthorne Hotel, Singapore.

Su Chi LIM, Melvin WONG, Wan Ching TOY, Angela MOH, Lee Ying YEOH, Dawn LAU,

Clara TAN, Tavintharan SUBRAMANIAM, Chee Fang SUM Urinary Proteomics of

Progressive Diabetic Nephropathy. Poster presentation. 2nd

NKF Scientific Meeting 22 Mar

2014

48

Mei Chung MOH, Tavintharan SUBRAMNIAM, Chee Fang SUM, Lee Ying YEOH, Xiao

Wei NG, Simon Biing Ming LEE, Wern Ee TANG, Su Chi LIM. Relationship between

anthropometric measurements of adiposity and arterial stiffness in subjects with type 2

diabetes The American Diabetes Association 74th

Annual Scientific Meeting June 13-17,

2014 at San Francisco

M. C. Moh, S. C. Lim, B. K. Lim, T. Subramaniam, C. F. Sum, and A. K. S. Cheng.

Evaluation On The Early Effects Of Bariatric Surgery On The Outcome Of Type 2 Diabetes

In Obese Patients. International Congress of Obesity. 17th

– 20th

March 2014, Kuala Lumpur,

Malaysia.

Tan SH C, Ang SF, Yeoh LY, Lim SC Exon sequencing of the APOE gene to identify

variants responsible for the monogenic basis of chronic kidney disease. Best Poster, Bronze

Award. Singapore Health & Biomedical Conference (SHBC) 2nd

and 3rd

Oct 2015, Singapore

Expo.

JJ Liu, SC Lim, JP Kovalik, S Ghosh, ES Tai, JH Ching, CN Ong, SKM Low, T

Subramaniam, CF Sum. Targeted Metabolomics Study Reveals Incomplete Fatty Acids

Oxidation and Abnormal Amino Acids Catabolism in Patients with Diabetic Kidney Disease

– a Metabolic Signature Suggestive of Mitochondria Impairment and Metabolic Inflexibility.

Oral Presentations (Basic). Asia Association for the Study of Diabetes (AASD), 21 November

2015 Hong Kong, China.

Su Chi Lim, Xiao Zhang, Na Li, Jian Jun Liu, Angela MC Moh, Chang Su, Serena KM Low,

Tavintharan Subramaniam, Lee Ying Yeoh, Chee Fang Sum. Prospective Study Suggests that

Central Arterial Stiffness Independently Predicts Albuminuria Progression in Asians with

Type 2 Diabetes. Best Oral Presentation (Overall), 18th

ASEAN Federation of Endocrine

Societies (AFES) Congress 10-13 Dec 2015, Kuala Lumpur Convention Centre, Malaysia

Low S, Lim SC, Yeoh LY, Liu JJ, Fun S, Su C, Zhang X, Subramaniam T, Sum CF. Novel

Insights into the Paradigm of Kidney Disease in Type 2 Diabetes – Lessons from a 13-Year

Retrospective Large Cohort Study. Best Poster (Diabetes Section), 18th

ASEAN Federation of

Endocrine Societies (AFES) Congress 10-13 Dec 2015, Kuala Lumpur Convention Centre,

Malaysia

Resham Lal Gurung, Yiamunaa M, Sylvia Liu, Jian-Jun Liu, Su Chi Lim. Short leukocyte

telomere length is associated with increased risk for albuminuria progression in type 2

diabetes in Asian. Oral Presentation. A-17-619-EASD. 53rd

European Association for the

Study of Diabetes 11-15 Sept 2017, Lisbon, Portugal.

APT-1 Abnormal Glycemic Control in East Asians with Pre-diabetes is Largely due to

Defects in Beta Cell Function rather than Peripheral Insulin Resistance. Poster Presentation at

ADA 2017.

Fong Choi Wan Jessie, Tan Si Hua Clara, Ang Su Fen, Yeoh Chai Kheng Ester, Tavintharan

Subramaniam, Sum Chee Fang, Lim Su Chi. Learning journey: Genetic counseling for a

proband with (MODY2) novel mutation (S441W in Glucose Kinase (GCK) gene) by Next

Generation Sequencing (NGS). World Congress on Genetic Counseling, 4-6 Oct 2017,

Wellcome Genome Campus, Hinxton, Cambridge, UK.

49

Book Chapters

Vascular Abnormalities in the Pre-Diabetic State, A. Enriqe Caballero, MD, Su Chi Lim,

MD, Edward S. Horton, MD and Aristidis Veves

Diabetes and Cardiovascular Disease by Michael T Johnstone & Arsitidis Veves (Editors).

June 15, 2001. Humana Press.

Submitted/In Preparation Manuscripts:

Jian-Jun Liu, Sujoy Ghosh, Jean-Paul Kovalik, Jianhong Ching, Hyung Won Choi,

Subramaniam Tavintharan, Choon Nam Ong, Chee Fang Sum, Scott A Summers, E Shyong

Tai and Su Chi Lim. Targeted plasma metabolomics suggests altered mitochondrial fuel

usage and remodelling of sphingolipid metabolism in individuals with type 2 diabetes

mellitus and kidney disease. Kidney International. (Submitted)

Resham Lal Gurung, Yiamunaa M, Sylvia Liu, Jian-Jun Liu, Su Chi Lim. Short leukocyte

telomere length predicts albuminuria progression in Asians with type 2 diabetes. Scientific

Reports (Submitted)

Resham Lal Gurung, Rajkumar Dorajoo, Sylvia Liu, Yiamunaa M, Jian-Jun Liu, Ling Wang,

Jian-Jun Liu, Su Chi Lim. Mendelian Randomisation analysis on urine haptoglobin and renal

function in type 2 diabetes in East Asians. Kidney International. (Submitted)

50

Lectures Given

The endothelium in type 2 diabetes. Plenary Lecture. 10th

Anniversary Institute for studies on

diabetes foundation, Inc. Manila, Philippines. 9 July 1999.

Managing the diabetic mothers. (Symposia on Medical Disorders in Pregnancy) 25 Mar 2000

What are the quality indicators for good diabetes management? The MOH Committee on

Clinical Practice Guidelines on Diabetes. 2 April 2000.

Endothelial dysfunction in type 2 diabetes. Singapore General Hospital monthly clinical

meeting 11 Nov 2000

The control of obesity in Singapore. 8th

May, 2001 Regional Meeting for the development of

a plan of action 2001-2005 for the Western Pacific Declaration on Diabetes. 8-11 May 2001,

Kaula Lumpur, Malaysia.

Endothelial dysfunction in type 2 diabetes/ Diagnosis & Classification of DM. Singapore

Naitonal Eye Center 13 June 2001

Prevention of vascular complications in type 2 diabetes. Servier symposium on Diabetes

Vascular complications for Indonesians Internists. 17 Aug 01.

Hyperglycemia and angiopathy: Endothelial dysfunction and glycation. Merck Symposium on

Achieving Optimum Glycemic Control in the Management of Type 2 Diabetes. 8th

Nov 2001,

ASEAN Federation of Endocrine Society (AFES), Bali, Indoensia.

Prevention of vascular complications in type 2 diabetes. Symposium on Evidence-based

management of Diabetes Mellitus; Chapter of Physician, Academy of Medicine. 1st Dec 01.

Clinical Non-invasive assessment of endothelial function. 3rd Congress of the Asian Pacific

Society of Atherosclerosis and Vascular Diseases (APSAVD) slated on February 17-20, 2002

in Cebu City.

Pitfalls in the management of diabetes. Pitfalls in Clinical Medicine. International Asian

Symposium of Internal Medicine 2002. University of Chiang Mai. 20 Nov 2002, Thailand.

Type 2 diabetes - a vascular disease. Coronary intervention in the diabetic patient - My

methods and rationale. Singapore Live2003 13th

Jan 2003 Suntec City, Singapore.

Running a Diabetes Nephropathy Clinic - experience from a referral centre in Singapore. 2nd

Cardiovascular Forum. 10 & 11th July 2004. Brisbane, Australia.

Management of type 1 and 2 diabetics in pregnancy Maternal Medicine Course 2004: 1st –3

rd

December 2004 Postgraduate Medical Institute Rooms 3&4, Singapore General Hospital

Molecular epidemiology of nephropathy secondary to type 2 diabetes. 16 May 05, Institute of

Molecular & Cell Biology, Biopolis / 19 Sept 05. Community Occupational & Family

Medicine, NUS

51

Needle-less solutions for diabetes. 17th

Singapore Pharmacy Congress. 1-4 July 2005, Grand

Copthorne Waterfront Hotel Singapore.

Pathophysiology and prevention of microvascular complications of diabetes. Singapore

General Hospital 15th

Annual Scientific Meeting 22 Apr 2005. Postgraduate Medical

Institute.

The many faces of diabetes. Symposium on diabetes – the king of modern epidemics.

National Health Group Annual Scientific Congress 30 Sept 2006. Raffles City Convention

Centre

Achieving euglycemia in pregnancy Maternal Medicine Course 2007: 12th

& 13th

January

2007. Institute of Health, MOH

Management of diabetes in pregnancy. 21st – 25

th March 2007. Sixth Singapore Congress in

Obstetric & Gynecology. Exploring New Frontiers For The Practising Obstetrician And

Gynaecologist Conrad Centennial Singapore

Diabetes – an over-view. 23rd

July 2007. Alumni Medical Centre, SGH. P-Medicines

Programme for Pharmacists. Pharmacists Society of Singapore.

Optimizing care of the pregnant diabetic. 26 Aug 2011. The 8th

International Congress of

O&G. Raffles City Convention Centre, Singapore.

Reflections of management of hyperglycemia: From past to present to future. Course in

Advance Endocrinology 3 - 5 Feb 2012, Pan Pacific Hotel, Singapore

Oral anti-diabetic agents: More is less? Mount Elizabeth Hospital Continual Medical

Education. 26 March 2012.

Oral anti-diabetic agents: More is less? Khoo Teck Puat Hospital Family Physician Continual

Medical Education. 24 Jul 2012.

Research for Clinician: my experiential sharing. Khoo Teck Puat Hospital Pharmacist and

Physiotherapy Continual Professional Education. 27 Jul 2012.

Clinical Management of Diabetic Nephropathy in a secondary-care institution. Singapore-UK

Workshop on Stratified Medicine in Diabetes. Matrix, Biopolis, Singapore. 26 Feb 2013.

Metabolic syndrome - and the link between diabetes, dyslipidemia and hypertension. 1st

Singapore Clinical Nutrition meeting. Singapore General Hospital. 7 Apr 2013

23rd Seah Cheng Siang Memorial Lecture. Journey with Diabetes: Lessons from Outliers

24th

August 2013. 2nd AMM‐AMS‐HKAM Tripartite Congress & 47th Singapore‐Malaysia

Congress of Medicine, Grand Copthorne Waterfront Hotel, Singapore.

Genetic for Chronic Disease (lecture to Doctors from NHG Polyclinics). 20th

Jan 2014. Khoo

Teck Paut Hospital.

52

Endocrine & Metabolic Society of Singapore- Mayo Course in Advanced Endocrinology.

Diabetes Pearls. 5th

March 2014. Grand Copthorne Waterfront Hotel, Singapore.

Panelist, Panel Discussion: Diabetes through the years. KTPH Diabetes & Metabolism

Symposium 2014. 5 Apr 2014. Grand Copthorne Waterfront Hotel, Singapore.

Facilitator, Case Discussion: Optimal glycemic management of diabetic chronic kidney

disease. Clinical Pearls in the glycemic and non-glycemic management of patient with

diabetic chronic and end-stage kidney disease. 26th

Apr 2014 Tan Tock Seng Hospital.

Updates in Diabetes in Pregnancy, Symposium: General Obstetrics. 4 May 2014. 10th ISUOG

Outreach Course, Singapore in conjunction with the 5th

Scientific Congress of the College of

O&G. Raffles City Convention Centre, Singapore.

Pathogenesis of diabetes and its complications. 20th

Sept 2014. 17th

AGM, Association for

Diabetes Educators, Singapore (ADES)

Predictors of weight loss after bariatric surgery – what have we learned? Asia Pacific

Metabolic & Obesity Surgery Summit. University Cultural Centre, National University of

Singapore 24th

Jul 2015.

Diabetic Nephropathy – Observations from Clinic and Cohort. Singapore Society of

Nephrology – Annual Scientific Meeting, Grand Copthorne Waterfront Hotel 25th

Jul 2015.

Optimizing treatment to prevent complications. Joslin-Sunstar Diabetes Education Initiative.

DIABETES, ORAL HEALTH AND NUTRITION. Raffles City Convention Centre –

Stamford Ballroom. 15th Jan 2016

Diabetes Pearls. Endocrine & Metabolic Society of Singapore (EMSS) – Mayo advanced

endocrinology course. 24-26 Feb 2016. Pan Pacific Hotel. Singapore.

Diabetic Nephropathy – Observations from Clinic and Cohort. Ng Teng Fong Hospital 29th

Apr 2016

Diabetic kidney disease – Observations from Clinics and Cohorts. National University

Hospital. 29th

Apr 2016

Diabetes and its complications – Observations from Clinics and Cohorts. Duke-NUS, Outram

Campus. 30th

May 2016

Research for clinician in Singapore – my brief experience. National Ophthalmology

Residents’ Research Day 2016, Auditorium, Khoo Teck Puat Hospital. 6th

Aug 2016

Genomic Medicine for Clinicians – Ready to Shift Paradigm? A/Prof Lim Su Chi, Clinical

Director, Clinical Research Unit, KTPH, 27th August 2016, 10.15am – 10.45am

53

Managing Diabesity – Weight Friendly Strategies. GP Symposium 2016. War on Obesity:

What a Family Physician Needs to Know. KTPH, Saturday 17 September 2016 (YCH

Auditorium)

Lee Kong Chian School of Medicine, 3rd

Year teaching session – Diabetic Nephropathy 11

Oct 2016.

Advance Internal Medicine Combined Teaching (TTSH & KTPH) - How To Interpret The

Research Paper. 27 October 2016

Overview for the Endocrine system. Master of Nursing students at ALCNS at NUS. 7th

Nov

2016.

Overview of endocrinology. First year medical student. Yong Loo Lin School of Medicine,

National University Hospital. 13th

Jan 2017

The many faces of diabetes. Mini-medical School, Alexandra Health System. 14th

Jan 2017.

Genomics in diabetes clinic – our early experience. Diabetes Symposium at MedLab Asia

Pacific Conference, The Sands Expo and Convention Centre. Singapore 3rd

Apr 2017.

Monogenic Diabetes case discussion. KTPH Annual Diabetes Symposium 22nd

Apr 2017.

Diabetic kidney disease – Observations from Clinics and Cohorts. 24 May 2017. Saw Swee

Hock School of Public Health, NUS.

The many faces of diabetes. Mini-medical School, Alexandra Health System. 15th

Jul 2017.

Presentation on Diabetic Kidney Disease for Theme 4, DYNAMO: Diabetes studY on

Nephropathy And other Microvascular cOmplications Consortium. Level 2 Amphitheatre,

Duke-NUS, 25 Aug 2017.

Managing diabetes: Tools in the physician’s war chest. Cardiometabolic Symposium by

Academy of Medicine Singapore - Managing Cardiometabolic diseases: A Practical Guide to

the Practising Physician. 16th Sep 2017 at National Heart Centre Lecture Theatre, Level 7

Diabesity – pathogenesis and clinical implications. Complex care track. Singapore

Biomedical Health Conference (SHBC) 13th October 2017. MAX Atria@Singapore Expo.

Diabetic kidney disease – what have we learned from our cohorts 16th

Nov 2017. Singapore

Symposium on Metabolic Diseases. A*STAR at Biopolis

“Precision medicine for diabetes– our preliminary experience in the clinics”. keynote

Speaker, Day 2, Singapore Molecular Diagnostics Symposium 2018. Symposium theme:

"Genomics in Healthcare". University Hall Auditorium, National University of Singapore,19-

20 April, 2018

54

Referees

1. A/Professor PEK Wee Yang.

Chairman Medical Board, Khoo Teck Puat Hospital

Email: [email protected]

2. A/Professor Kenneth MAK Seck Wai

Dy Director, Medical Service, MOH


3. A/Professor PANG Weng Sun

Chairman Medical Board, Yishun Community Hospital

Vice Dean, Clinical Affairs, Lee Kong Chian School of Medicine, NTU


3. Professor CHIA Kee Seng

Dean, Saw Swee Hock School of Public Health, National University of Singapore


4. A/Professor SUM Chee Fang

Senior Consultant, Diabetes Centre, Khoo Teck Puat Hospital


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