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CURRICULUM VITAE Personal Information

Name: MIKHLID HAMMAD ALMUTAIRI Nationality: Saudi Marital status: Married

Position:

King Saud University: Assistant Professor, Department of Zoology, Faculty of Science. Dean of Al-Ghad International College for Applied Medical Sciences, Riyadh

Specialization: Major: Genetics Minor: Medical Molecular Genetics

Current Address:

King Saud University: College of Science (Build. 5) - Dept. of Zoology, P.O. Box 2455, Riyadh 11451 Al-Ghad International College for Applied Medical Sciences, Riyadh: Al-Rafiah neighborhood, Wadi Al Lysan Street, 12751

Mobile Phone: 0593204047

Mail: King Saud University: malmutari@ksu.edu.sa Al-Ghad International College in Riyadh: riyadhd@gc.edu.sa

Academic Qualifications

Doctor of Philosophy in Medical Molecular Genetics (October 1st, 2014) (The North West Cancer Research Fund Institute), Bangor University, United Kingdom

Master of Science in Cell Biology, Genetics, and Histology (July 17th, 2007), Department of Zoology, Faculty of Science, King Saud University, Riyadh, Saudi Arabia

Bachelor of Science in Biology(July 13th, 1996), College of Education, King Saud University, Riyadh, Saudi Arabia

Career History

Faculty Member (Assistant Professor) of Molecular Genetics, December 17th, 2014 until now. Department of Zoology, Faculty of Science, King Saud University, Riyadh, Saudi Arabia

Lecturer in Genetics—July 19th, 2008 till December 12th, 2014, Department of Zoology, Faculty of Science, King Saud University, Riyadh, Saudi Arabia

Educational supervisor, Science subject— from September12th, 2003 to July 16th, 2008, Ministry of Education, Riyadh, Saudi Arabia.

Biology Teacher— from September 18th, 1996 to September 11th, 2003, Secondary School, Ministry of Education, Riyadh, Saudi Arabia

Administrative Responsibilities

Dean of Al-Ghad International College for Applied Medical Sciences, Riyadh, Saudi Arabia from July, 1st , 2019 until now

Dean of Al-Ghad International College for Applied Medical Sciences, Tabouk, Saudi Arabia from September, 18th, 2016 to June, 30th, 2019.

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Scientific Consultations

Full-time consultant at Al-Ghad International College for Applied Medical Sciences from 18/09/2016 until now.

Professional Certifications

Completion Certificate of SIDA Program for new faculty members, (United Kingdom).

Deanship of Skills Development Certificate from King Saud University for new faculty

members for the academic year 20152016, awarded upon completing 36 hours of training.

Areas of Research Interest

Identifying and characterizing Cancer/Testis antigens that may be used for development of cancer vaccines and/or diagnostic markers for several types of cancer.

Studying genetic variations of different genes in cancer in the Kingdom of Saudi Arabia.

Studying the relationship between smoking and mutations in immune genes among Saudi individuals.

Teaching Experiences

I’ve currently been teaching various courses at graduate level, Bachelor, such as General Zoology, Human Genetics, Principles of Genetics, and Molecular Biology.

I’ve also been teaching the following courses for Master students: Advanced Cytogenetics, and selected topics in cellular biology, genetics and tissues, writing research proposal, selected topics in Zoology, and scientific seminar.

Scholarships and Awards 1) Five- years Scholarship for doctoral degree at Bangor University, United Kingdom.

Granted by King Saud University. 2) Three-years grant for Master’s degree at King Saud University awarded by the Ministry of

Education 3) Cultural Attaché Award (Award for Excellence) for the academic year 2012/2013, United

Kingdom. 4) First Class Honors in Master of Science in Genetics, College of Sciences, King Saud

University, 2007. 5) Excellent Teacher Award in Biology from the Ministry of Education, 2002.

Research Grants

Principal Investigator in Research Project No. (2-17-01-001-0069) entitled “Identification and Characterization of New Cancer-Testis Antigen Gene Biomarkers in Saudi Patients with Colon Cancer” funded by the National Plan for Science and Technology, King Saud University (under implementation)

Principal Investigator of the project (12-MED2443-02) entitled “Investigating the deregulation of toll-like receptors, pro-inflammatory cytokines and cationic peptides by tobacco smoke and its role in promoting oral cancer in Saudi populations”. funded by the National Plan for Science and Technology (NPST) (completed)

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Principal Investigator of the project (R5-16-03-42) entitled “Identification of the Expression of 21 Genes of the MAGE Family in Colon Cancers in Saudi Patients “funded by the Deanship of Scientific Research at King Saud University (completed).

Principal Investigator of the research group (RG-1440-044), which is funded by the Deanship of the Scientific Research at King Saud University.

Assistant researcher in Genomic Research Chair, Biochemistry Department, Faculty of Science, King Saud University, from September, 2017 until now, which is funded by the Deanship of Scientific Research at King Saud University.

Assistant researcher of the research group (RGP-VPP-260), 04/05/2017, which is funded by the Deanship of Scientific Research at King Saud University.

Principal Investigator of the project (153-15-أط) entitled “Toxic, Teratogenic and Cytogenetic Effects of the Anticancer Drug, Gemcitabine, on Laboratory Mice”, which is funded by King Abdul Aziz City for Science and Technology. (completed)

Graduate Students Supervision I have been the main supervisor of the following four master’s students:

Raed Ammar Alsofyani(academic number, 435107085), thesis title "RT-PCR Expressions of MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A4 in Saudi Patients’ with Colon Cancer", which was completed in the second semester of 2016/2017 academic year.

Mohammad Sahab Almutairi (academic number, 438105292), research title "Evaluating the Genetic Variations of Human Beta Defensin1 among Saudi Cigarette Smokers (in progress).

Turki Mayudh Alrubie (academic number, 438105650), research title "Effect of Genetic polymorphisms of the Tumor Suppressor gene TP53 pathway in Saudi smokers and non-smokers" (in progress).

Riyadh Abdullah Almutairi (academic number, 438105941), research title "Association of Genetic Variations of Thymic Stromal Lymphopoietin and its Receptors among Saudi Colorectal Cancer Patients" (in progress).

Training and Workshops Overseas Courses and Workshops

1) Molecular Biology Summer Workshop, 2015, Smith College, USA (2 weeks, a total of 120 hours).

2) Computer skills course on how to write a thesis, 2013, Bangor University, UK (10 days, a total of 20 hours).

3) Two sessions of the Refworks program specializing in documenting and arranging research references, 2013, Bangor University, UK (1 day for each session, a total of 5 hours).

4) Training Course on MoticDigilab software, during 25-26 November, 2008 in Xiamen, China (10 hours).

5) Laboratory course on the modern methods of biotechnology during 16-26 February2009, National Research Center, Egypt (45 hours).

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Domestic Courses and Workshops King Saud University (Deanship of Skills Development)

1) Research skills in Scientific Databases, February 12th, 2020 (5 hours). 2) Specification and Report of the Academic Program, November 11th -12th, 2019 (10

hours).

3) Course on faculty members as peer consultants, April 10th 12th, 2016 (15 hours). 4) Writing project proposals and research grants, March 8th

9th, 2016 (10 hours). 5) Designing E-Courses, January 17th, 2016 (5 hours).

6) Scientific publishing in international journals, October 26th 27th, 2015 (10 hours). 7) Based learning course groups, October 25th, 2015 (5 hours).

8) Course on Blackboard, October 21st 22nd, 2015 (10 hours). 9) Workshop on intellectual property rights, copyright, and distribution, September 16th,

2015 (2 hours). 10) Microteaching, March 10th, 2015 (5 hours).

11) Evaluating learning outcomes, March 8th 9th, 2015 (10 hours).

12) Course on effective teaching, May 1st 3rd, 2015 (15 hours).

13) Design and construction of the course, February 22nd23 rd, 2015 (10 hours).

14) Preparing Data using SPSS, March 28th -30th, 2009 (15 hours).

Ministry of Education (Department of Educational Training and Scholarship)

15) The strategy of building information, June 17th 20th, 2008 (12 hours).

16) Training operations Leadership, May 19th 22nd, 2008 (16 hours).

17) Problem solving and making effective decisions, April 20th 29th, 2008 (12hours).

18) Cooperative learning, March 7th 10th, 2008 (12 hours).

19) Skills in building test questions, February 25th 26th, 2008 (8hours).

20) Building excellent tests, October 23rd 24th, 2007 (8 hours).

21) Effective dialogue skills, August 12th 15th, 2007 (12 hours).

22) CORT skills in thinking, April 3rd 7th, 2004 (15 hours).

23) Measuring the efficiency of teaching, March 6th 8th, 2004 (12 hours).

24) Effective educational supervision, April 17th 20th, 2004(16 hours).

25) Statistical analysis of the test, October 19th 21st, 2003 (12 hours).

26) Psychological engineering applications, August 29th September 2nd, 2003 (20 hours).

27) Classroom question skills, May 18th 20th, 2003 (12 hours).

28) Teaching methods, June 22nd 26th, 2002 (15 hours).

29) Planning test contents, June 15th 19th, 2002 (15 hours).

30) Modern teaching aids, April 29th May 1st, 2000(12 hours). 31) Five courses on using computers, September10th -November1st, 2000 (75 training

hours).

Other Government Entities 32) Attending a workshop entitled "Techniques of Writing Questions", which was held by

the Department of Professional Examinations at the National Center for Assessment during the period from 25/01/2017 (10 hours of training).

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33) Attending a workshop entitled "Molecular Biology Technologies (Principles and Applications)" which was held in the Department of Life Sciences at King Khalid University in Abha (3 days, a total of 15 hours).

34) Environmental education course for supervisors, Saudi Wildlife Authority (5 days, a total of 20 hours).

35) Two courses in the principles of first aid, Saudi Red Crescent Authority (4 days each course for a total of 16 hours).

36) School Management, Al Imam University (16 days, a total of 32 hours). 37) Educational Supervision, Al Imam University (16 days, a total of 32 hours).

Committee Memberships and Activities Department of Zoology

Faculty Representative at a meeting for the Panel of External Auditors of the National

Commission for Academic Accreditation and Assessment, April 1819, 2016.

Representative of the Committee for Laboratories, Equipment, and Services at a meeting for the Panel of External Auditors of the National Commission for Academic Accreditation

and Assessment, April 2021, 2016.

Member of the Department of Zoology, December 17th, 2014 until now.

Member of the teaching assistants and scholarships committee, December 23rd, 2014 until now.

Member of the Committee on Development and Quality (Computers and Internet), December 23rd, 2014 until now.

Member of the Committee for Laboratories, Equipment, and Services, December 23rd, 2014 until now.

Secretary of the Committee for Laboratories, Equipment, and Services for the academic year 2008/2009.

King Saud University

Team member on the project “Study Delay and Psychological Support”, numbered 25126/4/1, November 29th, 2015.

Introducing the course “Building Test Questions Using Table Specifications” to the Deanship of Skills Development, January 24th

25th, 2016(10 hours).

A member of Genome Research Chair- at King Saud University, Saudi Arabia, from January, 2018 until now.

A member of research group program, numbered RGP-VPP-260.

Al-Ghad International College for Applied Medical Sciences, Tabouk

Head of Academic Quality Unit.

Head of Clinical Training Unit.

Head of the Committee for the development of faculty members.

Head of the Committee for the follow-up of graduate students.

Head of the Examinations Committee.

Head of the Committee for the preparation of new students.

Head of the self-study committee and the annual report.

Head of the Student Advisory Council.

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Head of the Preparation Committee for the fourth and fifth graduation ceremonies honoring His Royal Highness Prince of Tabouk for the academic years 1438-1439 and 1439-1440.

Al-Ghad International College for Applied Medical Sciences, Riyadh

Head of the Committee for the follow-up of graduate students

Head of Academic Quality Unit.

Head of Clinical Training and internship Unit.

Head of the Committee for the development of faculty members.

Head of Examinations Committee.

Head of the Procurement and Maintenance Committee.

Head of the Student Advisory Council.

Head of the committee to attract bridging students to join Al-Ghad International Colleges of Applied Medical Sciences

A member of the Committee for Enumeration of Al-Ghad International Colleges of Applied Medical Sciences in Riyadh to move to the new building.

Community Service

A member of the Executive Council of Al-Ghad International Colleges of Applied Medical Sciences, Riyadh, KSA, from the academic year 2019-2020 until now.

A member of Board of Trustees of Al-Ghad International Colleges for Applied Medical Sciences, Riyadh, KSA, from the academic year 2017-2018 until now.

A member of Board of Deans of Al-Ghad International Colleges for Applied Medical Sciences, Riyadh, KSA, from the academic year 2017-2018 until now.

A member of the committee for Evaluating and Modifying Biology textbook for the first year of secondary school during academic year 2006/2007, Ministry of Education.

A member of the committee for Evaluating and Modifying Biology textbook for second year of secondary school (total of two books for the first and second semester) during the academic year 2006/2007, Ministry of Education.

A treasurer of the Saudi Club for the thirty-first session, 2012, Bangor, United Kingdom.

A trainer Collaborator at Deanship of Skills Development, 2016, King Saud University.

A trainer at Raiz Institute for Training and Development, 2004-2007.

Collaborating with the National Center for Assessment to write achievement tests in biology, April 30, 2015 until now.

Collaborating with the National Center for Assessment to write proficiency teacher test in Biology and Science.

Principal supervisor for the Computer Club, Riyadh, Ministry of Education.

Preparing the helping guide in scientific terminology for Microscope slide in Biology. Accredited by the general director in the Ministry of Education.

Workshops and training for Biology teachers, Ministry of Education.

A member of the committee for evaluating the grades of secondary school for Biology course, 1999-2003, Ministry of Education.

Conferences and Symposiums

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Overseas Conferences and Symposiums 1) Attending a conference titled “MicroRNAs and Noncoding RNAs in Cancer”, June 7th

12th, 2015, Keystone City, Colorado, USA.

2) Attending the Meiosis conference, August 29th September 3rd, 2015, Oxford, UK. 3) Participating in the 2018 Conference of Synthetic Biomaterials, September, 19-20, 2018,

Tokyo, Japan. Presentation title: Novel Sequence Variants in the TLR6 Gene associated with the

Advanced Breast Cancer Risk in Saudi Population. Yousef Hawsawi; Nouf Al-Nomair; Mikhlid Almutairi; Narasimha Reddy Parine; Abdullah Al Amri; Mohammad Saud Alanazi; and Abdelhabib Semlali.

Domestic Conferences and Symposiums 1) Attending the eighth annual forum on the occasion of celebrating the International Day

against Corruption 2019, which is held on Monday 12/4/1441 AH, corresponding to 9/12/2019 in Riyadh.

2) Participating in the International Conference on Medical Genome Research, December

11th 13th, 2015, King Abdulaziz University, Jeddah, Saudi Arabia Research title: “Identification of New Cancer Testis Antigen Genes in Diverse Types

of Malignant Human Tumor Cells” 3) Attending a seminar on establishing partnerships between universities and the private

sector in scientific research, October 28th 29th, 2015, King Saud University. 4) Attending the second International Conference for Scientific Publishing, October 11th

13th, 2015, King Saud University. 5) Attending the International Conference: preparing and developing future teachers,

October 6th -7th, 2015, King Saud University. 6) Attending a scientific meeting titled “Breast Cancer among Women in Saudi Arabia”,

September 9th, 2015, King Faisal Specialist Hospital and Research Center, Riyadh.

Laboratory teaching skills Molecular Biology and Genetics

Extraction of DNA and RNA from blood, tissues and cells in culture.

Reverse transcriptase PCR (RT-PCR)

Quantitative PCR (qRT-PCR)

Primer Design for RT-PCR and real time PCR

SNP disease correlations.

Genotyping and Gene Expression.

Gel electrophesis (agarose and PAGE)

Karyotyping and Chromosomal aberration techniques.

DNA cloning strategies

RNA interference (RNAi and siRNA)

Immunohistochemistry

Cellular Biology

Cell and tissue culture.

Maintain cell lines in culture.

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Publications Scientific research:

1) Abdelhabib M. Semlali, Mikhlid H. Almutairi, Sultan N. Alharbi, Abdullah M. Al Amri, Abdulwahed F. Alrefaei, Bader O. Almutairi, and Mahmoud Rouabhia, 2020.Impact of Expression and Single Nucleotide Polymorphisms of Thymic Stromal Lymphopoietin Receptor on Breast Cancer Progression. (Submitted to Scientific Reports, Under Review).

2) Mikhlid Almutairi, Mahmoud Rouabhia, Mohammad Sahab Almutairi, Mohamed Al Zahrani, Nouf S. AL-Numair, Abdullah Mohammed Alhadeq, and Abdelhabib Semlali, 2020. Correlation between Genetic Variation in Thymine DNA Glycosylase and Smoking Behavior. (Submitted to Scientific report, Under Review).

3) Mikhlid H. Almutairi; Nouf S. Al-Numair; Bader O. Almutairi; Abdulwahed F. Alrefaei; Mahmoud Rouabhia; Narasimha Reddy Parine; and abdelhabib Semlali, 2020. A Possible Genetic Interactions between methylenetetrahydrofolate reductase (MTHFR) Genotype and Smoking Behavior. (Submitted to Molecular Genetics & Genomic Medicine, Under Review).

4) Semlali, abdelhabib; Almutairi, Mikhlid ; Alanazi, Ibrahim; AwadAljohi, Hasan ; Reddy Parine, Narasimha ; M Alhadeq, Abdullah ; A, Al-Jafari , Abdulaziz; F Mobeirek, Abdulelah; Al Amri, Abdullah ; P Shaik , Jilani ; Filali, Fatima-zohra; and Alanazi, Mohammad,2019. Toll-like receptor 4 polymorphisms in Saudi population with cardiovascular diseases. Molecular Genetics & Genomic Medicine,DOI: 10.1002/mgg3.852, pp.1-15

5) Abdelhabib Semlali, Mikhlid Almutairi, Narasimha Reddy Parine, Abdullah Al Amri, Rafa Almeer, Mohammad Saud Alanazi, and Mahmoud Rouabhia, 2019. TSLP and TSLP receptors variants are associated with smoking. Molecular Genetics & Genomic Medicine, DOI: 10.1002/mgg3.842, pp.1-17).

6) Abdelhabib Semlali, Mikhlid Almutairi, Narasimha Reddy Parine, Abdullah Al Amri, Rafa Almeer, Mohammad Saud Alanazi and Mahmoud Rouabhia.2019. Expression and allele frequencies of TSLP are a key factor of breast cancer risk. Molecular Genetics & Genomic Medicine, DOI: 10.1002/mgg3.813, pp.1-10.

7) Abdelhabib Semlali, Mikhlid Almutairi, Akbar Ali Khan Pathan, Narasimha, Reddy Parine, Abdullah Al Amri, Maha Arafah, Abdulrahman M Aljebreen, Othman alharbi, Majid A Almadi, Nahla Ali Azzam, Mahmoud Rouabhia and Mohammad Alanazi, 2019. Toll-like receptor 6 expression, sequence variants and its association with colorectal cancer risk. Journal of Cancer, 10(13), pp.2969-2981.

8) Mikhlid Almutairi, Abdullah Mohammad Alhadeq, Rafa Almeer, Mohammed Almutairi, Mohammed Alzahrani and Abdelhabib Semlali, 2019. Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population. Molecular Genetics & Genomic Medicine, p.e590

9) Mikhlid Almutairi and Abdelhabib Semlali, 2019. Relationship between MAGE-A1 gene Polymorphisms and Colorectal Cancer Developments in Saudi Patients. Genetics & Molecular Research 18 (1): gmr16039940.

10) Mikhlid Almutairi, Rafa Almeer, Abdullah M Alhadheq, and Abdelhabib Semlali, 2018. Interleukin-7 Receptor Gene rs12516866 Polymorphism Decreases the Susceptibility of

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Estrogen Receptor Negative Saudi Women to Breast Cancer. Genetics and Molecular Research 17 (4): gmr16039935.

11) Abdelhabib semlali; Narasimha Reddy Parine; Nouf S. Al-Numair; Mikhlid Almutairi; Yousef M Hawsawi; Abdullah Al Amri; Abdulrahman M Aljebreen; Maha Arafah; Majid A Almadi; Nahla Ali Azzam; Othman alharbi; Mohammad Alanazi,2018. Potential role of Toll-like receptor 2 expression and polymorphisms in colon cancer susceptibility in Saudi Arabian population. OncoTargets and therapy, 2018:11, 8127-8141.

12) Abdelhabib Semlali; Mikhlid Almutairi; Narasimha Reddy Parine; Abdullah Al Amri; Mohammad Saud Alanazi; Nouf Al-Nomair; and Yousef M Hawsawi, 2018. Novel sequence variants in the TLR6 gene associated with advanced breast cancer risk in the Saudi Arabian population. PLoS One, 13(11):e0203376.

13) Planells-Palop, V., Hazazi, A., Feichtinger, J., Jezkova, J., Thallinger, G., Alsiwiehri, N.O., Almutairi, M., Parry, L., Wakeman, J.A. and McFarlane, R.J., 2017. Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis. Molecular Cancer, 16(1), p.84.

14) Semlali, A., Almutairi, M., Parine, N.R., Al Amri, A., Shaik, J.P., Al Naeem, A., Ajaj, S.A., Rouabhia, M. and Alanazi, M.S., 2017. No genetic relationship between TLR2 rs4696480, rs3804100, and rs3804099 gene polymorphisms and female breast cancer in Saudi populations. OncoTargets and therapy, 10, p.2325.

15) Suliman Y. Alomar, Lamjed Mansour, Abdulwahab Abuderman, Afrah Alkhuriji, Maha Arafah, Saleh Alwasel, Abdel Halim Harrath, Mikhlid Almutairi, Paul Trayhyrn, Javid Ahmad Dar. 2016. β-Catenin accumulation and S33F mutation of CTNNB1 gene in colorectal cancer in Saudi Arabia. Pol J Pathol67 (2): 156-162

16) FEICHTINGER, J., ALDEAILEJ, I., ANDERSON, R., ALMUTAIRI, M., ALMATRAFI, A., ALSIWIEHRI, N., GRIFFITHS, K., STUART, N., WAKEMAN, J.A., LARCOMBE, L. and MCFARLANE, R.J., 2012a. Meta-analysis of clinical data using human meiotic genes identifies a novel cohort of highly restricted cancer-specific marker genes. Oncotarget, 3(8), pp. 843-853.

17) Abou-Tarboush, F. M.; Abdel-Samad, M. F. and Al-Mutairi, M. H. Developmental Toxicity of Orally Administered Sildenafil Citrate (Viagra) in SWR/J Mice. Saudi J. Biol. Sci. 18(2): 135-139.

Authored Books 1) Fahad Al-Akeel, Sulaiman Al-Habib, Mikhlid Al-MUTAIRI, Ahmad Al-Sadoon,Saad Al-

Ghamdi, Mohammed Al-Souid, Ahmed Al-Fouzan. 2007-2008. Biology textbook for the first year of secondary school, Ministry of Education.

2) Fahad Al-Akeel, Sulaiman Al-Habib, Mikhlid Al-MUTAIRI, Ahmad Al-Sadoon, Mohammed Al-Souid, Ahmed Al-Fouzan. 2007-2008. Biology textbook for the second year of secondary school (first semester), Ministry of Education.

3) Fahad Al-Akeel, Sulaiman Al-Habib, Mikhlid Al-MUTAIRI, Ahmad Al-Sadoon, Mohammed Al-Souid, Ahmed Al-Fouzan. 2007-2008. Biology textbook for the second year of secondary school (second semester), Ministry of Education.

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Interests and Hobbies

Football and Volleyball

Computer Skills

Extensive Knowledge of Microsoft Office Programs (Word, Excel, PowerPoint).

Internet Explorer

SPSS program

References Available upon request