CURRICULUM VITAE MAKEDONKA MITREVA, Ph.D. (née Dautova ... · Academic Medical Leadership...

Curriculum Vitae November 27th, 2018Makedonka Mitreva, PhD Page

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CURRICULUM VITAE MAKEDONKA MITREVA, Ph.D. (née Dautova)

DATE: December 21th, 2018 CITIZENSHIP: Naturalized US Citizen ADDRESS AND TELEPHONE NUMBERS: McDonnell Genome Institute, Campus Box 8501 Washington University School of Medicine 4444 Forest Park Boulevard St. Louis, MO 63108 [email protected] Office: 314-286-2005 Fax: 314-286-1810 PRESENT POSITION: Washington University School of Medicine, St. Louis, MO Associate Professor of Medicine, Department of Medicine Associate Professor of Genetics, Department of Genetics Assistant Director, McDonnell Genome Institute Co-Director, Center for Clinical Genomics of Microbial Systems EDUCATION: Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia Faculty of Natural Sciences and Mathematics B.Sc., Biochemistry and Physiology (1986-1990) Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia Faculty of Natural Sciences and Mathematics M.Sc., Biology (1991-1994) Advisors: Drs. Marina Georgievska, Mirko Spasenovski and Milton Mulev Dissertation: Morphological changes among tomato and tobacco during their vegetation caused by the presence of the nematodes Meloidogyne spp Wageningen University and Research Centre, Wageningen, The Netherlands Laboratory of Nematology Ph. D. in Plant Sciences, Molecular & Population Genetics (1997-2001) Advisors: Drs. Jaap Baaker, Fred Gommers and Geert Smant Dissertation: Population and molecular genetics of root-knot nematodes (link: http://library.wur.nl/WebQuery/wurpubs/fulltext/198991) Washington University School of Medicine, St. Louis, MO ` Department of Genetics Research Associate (2002-2004) Advisor: Robert H. Waterston / Richard K. Wilson ACADEMIC POSITIONS / EMPLOYMENT:


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Washington University School of Medicine, St. Louis, MO Senior Scientists, Department of Genetics (2004-2005) Research Instructor, Department of Genetics (2005-2006) Manager of Genome Analysis, Genome Sequencing Center (2006-2008) Group Leader, Microbial/Vector&Pathogens Genomics, The Genome Institute (2008-2016) Assistant Director, McDonnell Genome Institute (2008-present) Assistant Professor of Genetics, Department of Genetics (2007-2014) Assistant Professor of Medicine, Department of Medicine (2012-2014) Co-Director, Center for Clinical Genomics of Microbial Systems (2014-present) Associate Professor of Medicine (WITH TENURE), Department of Medicine (2014-present) Associate Professor of Genetics (WITH TENURE), Department of Genetics (2014-present) Plant Research International, Wageningen, The Netherlands Researcher (2001-2002) Ss Cyril and Methodius University of Skopje, Macedonia Institute of Southern Crops Instructor in Plant Protection (1998-2002) Vrijland Trading, Monster, The Netherlands Cultivation Department Executive Manager (1995-1997) UNIVERSITY AND HOSPITAL APPOINTMENTS AND COMMITTEES: Washington University School of Medicine, St. Louis, MO Co-Leader, Shotgun Microbiome Working Group (Human Microbiome Project) (2009-2012) Microbial Genomics at TGI, steering committee member (2012-1014) DBBS Member: a) Computational and Systems Biology Program, b) Molecular Genetics and Genomics Program and c) Molecular Microbiology and microbial pathogenesis. (2013-present) Member, Institute of Clinical and Translational Sciences (ICTS)(2013-present) Co-Director Center for Clinical Genomics of Microbial Systems (CC-GEMS)(2014-present) Member, Academic Women’s Network at WUSM (2015-present) Full Member, Digestive Diseases Research Core Center (DDRCC)(2016-present) Faculty Scholar, Institute for Public Health (IPH)(2017-present) HONORS AND AWARDS: Talented Students Scholarship, Ministry of Science, Macedonia (1991-1994) Awarded Graduate Scholarship, Wageningen University, The Netherlands (1997-2001) Storm-van der Chijs Stipendium, creativity and self-initiative in scientific research, The Netherlands (2000) Best Ph.D. student paper award, Society of Nematologists, USA (2001) Genome Technology 2011 “Tomorrow’s PIs’ (2011) Academic Medical Leadership Development Program for Physicians and Scientist (2016) EDITORIAL RESPONSIBILITIES Editorial Board: Sequencing (2008-2010)


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Associate Editor: PLoS Neglected Tropical Diseases (2015-present) Guest Editor: Frontiers in Genetics, special issue ‘Novel Frontiers in Helminth Genomics’ (2018-present) PLoS Pathogens (2018) Review activities for Academic Journals (not all are listed): Nature journals (Nature, Nature Genetics, Nature Biotechnology, Nature Protocols); PLoS journals (Genetics, NTD, Computational Biology, ONE); BMC journals (Genomics, Biology); Genome Research, Nucleic Acids Research, Bioinformatics; International Journal of Parasitology, Parasitology, Molecular and Biochemical Parasitology, Journal of Nematology. NATIONAL SCIENTIFIC PANELS: Review Panel Member, National Science Foundation, 2006 and 2007 Review Panel Member, Welcome Trust, UK; USDA (CSREES) and NIH (SCR), 2007 and 2009 Review Panel Member, National Institute of Health (NIH) Institutes (SCR), 2010 and 2011 Reviewer, Medical Research Council (MRC), 2013 Reviewer, Oak Ridge AU, 2013 Review Panel Member, NIH (DHHS/NIAID/DEA/SRP), 2013 Review Panel Member, NIH (NHGRI, ZHG1 HGR-L M1), 2015 Review Panel Member, BBSRC – UK, 2016 Review Panel Member, NIH (NIAID, ZAI1 LR0M-S1), 2016 Review Panel Member, NIH (NIGMS), 2017 Reviewer, NIH (ZRG1 BCMB-A (51) R), 2018 Review Panel Member, NIH (NIAID, ZAI1 EC-M (J1)), 2018 PROFESSIONAL SOCIETIES AND ORGANIZATIONS: Membership in Professional Societies: Member, American Society of Tropical Medicine and Hygiene (ASTMH) Member, American Society for Parasitologists (ASP) Member, American Society for Microbiology (ASM) Professional Society Service: Member of Scientific Program Committee, ASTMH (2018-present) Member of Education Committee, ASP (2018-present) Chair and/or organizer of international symposiums/workshops: 2012 Session chair at the “Evolution of Caenorhabditis and other nematodes”, Cold Spring

Harbor Laboratories, New York, USA 2014 13th International Congress of Parasitology, Mexico City, Mexico 2015 Organizer of the “International Workshop on Helminth Genomics”, St. Louis, MO 2016 Organizing member of a symposium at the “Anthelmintics: From Discovery to

Resistance”, San Diego, CA


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2016 Organizing member of a symposium “Microbiome in Health and Diseases” at the 17th International Congress on Infectious Diseases, Hyderabad, India

2017 Member of the Scientific Committee for the “Molecular Helminthology-An integrated approach” conference, Cape Cod, Massachusetts, USA

2017 Session Chair, ASTMH 66th Annual Meeting, Baltimore, Maryland, USA 2018 Organizing member of a symposium and chair “Genome Biology of Parasites” at the

14th International Congress of Parasitology, Daegu, Korea 2018 Organizing member of a symposium and chair “Paragonimus and paragonimiasis” at

the 14th International Congress of Parasitology, Daegu, Korea 2018 Session Chair, ASTMH 67th Annual Meeting, New Orleans, LA, USA MAJOR INVITED PROFESSORSHIPS AND LECTURESHIPS: Invited speaker: 2004 • XIth International Conference on Trichinellosis, August 8-12, 2004, San Diego, California.

Title: Discovery of Candidate Developmentally Expressed Genes in Trichinella spiralis. • XXVII International Symposium of the ESN, June 14-18, 2004, Rome, Italy. Title: Discovery

of Developmentally Expressed Genes in Plant Parasitic Nematodes. 2005 • Molecular Helminthology, An Integrated Approach (Keystone Symposia), April 9-13 Copper

Mountain, Colorado. Title: Investigating hookworm genomes by comparative analysis of two Ancylostoma species.

2006 • The George Washington University, Department of Microbiology, Immunology and Tropical

Medicine, November 29, 2006, Wash. DC. Title: From Parasite genome to parasite control. • European Society of Nematologists, XXVIII International Symposium, June 11-14, 2006,

Blagoevgrad, Bulgaria. Title: Identification and characterization of coding nematode-specific multy-species conserved sequences.

2007 • Functional Genomics in a Parasitic Model, September 21-23, 2007, Azores, Portugal. Title:

Nematode ESTs: Generation, navigation and annotation. • World Association for the Advancement of Veterinary Parasitology, August 19-23, 2007,

Ghent, Belgium. Title: Parasitic Nematodes: from genomes to control. • 16th International C. elegans meeting, June 29 – July 1, 2007, Los Angeles, California.

Title: Genomes of Parasitic Nematodes. • From Alaska to Chiapas: The First North American Parasitology Congress, June 15-21,

2007, Merida, Mexico. Title: Parasitic Nematodes: from genomes to control. • BSP Spring and Malaria meeting 2007, April 15-18, 2007, Belfast, UK. Title: Parasitic

Nematodes: from genomes to control. • Microbial Genomes, April 11-14, 2007, Hinxton, UK. Title: Sequencing and comparative

analysis of human gut microbiome. 2008 • 5th International Congress of Nematology, July 13-18, 2008, Brisbane, Australia. Title:

Gene finding, expression profiling, and SNP detection in Ancylostoma caninum using high throughput sequencing technology and its implications; Title: Plant Parasitic Nematode – restricted indels inferred from nematode transciptomic data; Title: The impact of next-generation sequencing technologies on parasitic nematode genomics.


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• WHO/TDR Targets Database Network, March 11-14, 2008, Buenos Aires, Argentina. Title: Parasitic Nematode Genomics, update for 2008.

• Parasitology Seminar, University of Pennsylvania, April 6, 2008, Philadelphia, Pennsylvania. Title: Comparative Nematode Genomics: past, present and future.

2009 • WHO/TDR Targets Database Network, January 17-18, 2009, Philadelphia, Pennsylvania,

Title: Parasitic Nematode Genomics, update for 2009; Title: Nematode.net, update for 2009.

2010 • The Human Microbiome Research Conference, August 31-September 2, 2010, St. Louis,

Missouri. Title: Shotgun metagenomic sequencing and analysis at the Washington University Genome Center.

• The Electrical and Computer Engineering CUDA, April 6th, 2010, University of Illinois at Urbana-Champaign, Urbana, Illinois. Title: Our second genome.

• The WormBase meeting, January 11-13, 2010, California Institute of Technology, Pasadena, California. Title: Nematode.net: parasitic nematode database.

2011 • International Human Microbiome Congress, March 9-13, 2011, Vancouver, Canada. Title:

The Microbiome of healthy humans, commonalities and variations; Title: The microbiome of Healthy Humans: USA and EU.

• The Biology of Genomes, May 10-15, 2011, CSHL, Cold Spring Harbor, New York. Title: The human microbiome: looking for biology in tera-bases of sequence data.

• 1st International Workshop on Tropical Microbial Ecology, May 17-21, 2011, La Selva, Costa Rica. Title: Ecology of the human microbiome.

• American Society for Microbiology, May 21-24, 2011, New Orleans, Louisiana. Title: Analysis of terabase-scale metagenomic data: keeping pace with data production.

• Fiftieth Annual Meeting of the Society of Nematologists, July 17-20, 2011, Corvallis, Oregon. Title: The evolution of nematode genomics.

• 3rd Next Generation Sequencing Congress, November 14-15, 2011, London, UK. Title: The microbiome of healthy humans explored through tera-bases of sequence data.

2012 • Evolution of Caenorhabditis and other nematodes, April 3-6, 2012, CSHL, New York. Title:

Exploring metazoan evolution through dynamic and holistic changes in protein families and domains.

• DOLF Helminth Diagnostics, April 18-20, St. Louis, Missouri. Title: The role of genomics in diagnostics of helminth NTDs.

• Infectious Disease Genomics and Global Health, May 7-11, 2012, Suzhou, China. Title: Repositioning existing drugs to combat neglected diseases.

2013 • The Genomics of Common Diseases, September 7-10, 2013, Keble College, Oxford, UK.

Title: Genomics Empower Research on Neglected Tropical Diseases. • International Human Microbiome Consortium, September 11-15, 2013, Hangzhou, China.

Title: Gut microbiome dynamics of humans infected with gastrointestinal parasites. 2014 • Anthelmintics: form discovery to resistance: February 5-7, 2014, San Francisco, CA. Title:

An integrated multi-omics approach empowers development of anthelmintic drugs.


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• University of California San Diego invited talk: March 11, 2014, UC San Diego, CA. Title: An integrated multi-omics approach to study helminth infections.

• Molecular Helminthology, September1-6, 2014, Hydra, Greece. Title: Beyond the helminth genomes.

• Prostate Cancer Foundation, invited online talk: October 25, 2014. Title: Application of genomic and metagenomic approaches in infectious diseases.

2015 • World Healthcare Students’ symposium, invited talk: November19-22, 2015, Skopje,

Macedonia. Title: The human microbiome: its role in health and disease. • Leiden University Medical Center, invited talk: November 23, 2015, Leiden. The

Netherlands. Title: The helminth genome and metagenome. 2016 • II Anthelmintics: From development to Resistance, invited workshop presentation, February

9-12th, 2016, San Diego, CA. Title: Helminth genomics – looking for biology in tera-bases of sequence data.

• 17th International Congress on Infectious Diseases, March 2-5th, 2016, Hyderabad, India. Title: The healthy human antibiotic resistome: a multi-body habitat analysis.

• Annual Midwestern Conference of Parasitologists (AMCOP), invited symposium speaker, June 9-11th, 2016, Soutern Illinois University, Carbondale, IL. Title: Soil-transmitted helminthes and the human gut microbiome.

• *32nd Symposium of European Society of Nematologists. Aug 28-September 1th, 2016, Braga, Portugal. Title: Beyond the nematode genomes. *Plenary speaker.

2017 • Molecular Helminthology: An integrated approach, invited speaker, March 19-22, 2017,

Cape Cod, MA. Title: Knowledge based target and drug discovery. • GNID: Evolution, Virulence and Pathogenesis, March 7th, 2017, NIH Campus, Bethesda.

Title: Taxonomic, genetic and functional gut microbiome assemblages in humans infected with STHs.

• Challenges in Metagenomics and Microbiome, April 28th, MilliporeSIgma, St. Louis, MO. Title: Taxonomic, genetic and functional gut microbiome assemblages in humans infected with STHs.

• ZIBI Summer Symposium, Ecology of Infectious Diseases, June 26-27th, 2017, Freie Univeristy, Berlin, Germany. Title: Cross-Kingdom interactions in the human gut ecosystem.

• 50th Annual Meeting and Golden Jubilee of the Society of Invertebrate Pathology, August 13-17, 2017, UC San Diego, La Jolla, CA. Title: Looking for nematode biology in tera-bases of sequence data.

• Millipore Sigma Scientific Symposium 2017 and Life Science Center grand opening, October 11th, 2017, Burlington, MA. Title: Looking for biology in tera-bases of microbiome data.

• Case Western Reserve University, Center for Global Health & Diseases, Cleveland, Ohio. December 15th, 2017. Title: Genomics Empower Research on Neglected Tropical Diseases.

2018 • Workshop on Parasitic Nematodes, NYUAD Center for Genomics and Systems Biology

January 4-6, 2018, Abu Dhabi. Title: Looking for nematode biology in tera-bases of sequence data.


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• 14th International Congress of Parasitology (ICOPA) 2018, August 19-24, 2018, Daegu, S. Korea. Title: A reverse vaccinology approach for identifying STH vaccine candidates.

• *14th International Congress of Parasitology (ICOPA) 2018, August 19-24, 2018, Daegu, S. Korea. Title: metaGenomics of parasitic helminthes. *Keynote speaker.

• *14th International Congress of Parasitology (ICOPA) 2018, August 19-24, 2018, Daegu, S. Korea. Title: Looking for biology in the genomes of lung flukes. *Keynote speaker.

WUSM Invited speaker: 2003 - present • Department of Molecular Microbiology, Tropical and Molecular Parasitology Seminar,

February 18, 2003. Title: Comparative Analyses & Functional Classification of Transcripts Expressed in Parasitic Nematodes.

• Department of Molecular Microbiology, Tropical and Molecular Parasitology Seminar, March 2nd, 2004. Title: Comparative Genomics of Gene Expression in Parasitic and Free-Living Nematodes.

• Department of Molecular Microbiology, Tropical and Molecular Parasitology Seminar, February 18, 2005. Title: An analysis of transcripts from three infective larvae (L3) cDNA libraries of Brugia malayi.

• Center for Computational Biology, Seminar series, December 7th, 2006. Title: From Parasite genome to parasite control.

• Department of Genetics, Seminar series, October 4th, 2007. Title: Parasitic nematodes: from genomes to control.

• Division of Statistical Genomics, Metagenomics Forum, February 23rd, 2009. Title: Exploring the human microbiome: metagenomic shotgun approach.

• Department of Molecular Microbiology, Tropical and Molecular Parasitology Seminar, March 11th, 2009. Title: Molecular determinants archetypical to the Phylum Nematoda.

• Department of Molecular Microbiology, Tropical and Molecular Parasitology Seminar, February 20th, 2013. Title: Repositioning existing drugs to combat neglected diseases.

• Department of Pediatrics, ID divisional research conference series, November 4th, 2013. Title: An integrated multi-omics approach empowers development of anthelmintic drugs.

• Department of Internal Medicine, Infectious Diseases Genomics seminar, November 8th, 2013. Title: Gut microbiome dynamics of humans infected with gastrointestinal parasites.

• NeuroID Interest Group Meeting, January 2nd, 2015. Title: Genomics of microbial systems and communities.

• Department of Internal Medicine, Infectious Diseases Genomics seminar, November 5th, 2015. Title: Structured phylogeography relates to Onchocerca volvulus phenotypic divergence of pathogenicity.

• Department of Internal Medicine, Infectious Diseases Retreat, May 12th, 2017. Title: How to develop a good research question addressed with “omics”.

• Division of Gastroenterology Research Conference, February 16th, 2018. Title: Differential human gut microbiome assemblages during parasitic infections and after clearance.

• Bayer Graduate Fellows Symposium, November 2nd, 2018. Title: Omics driven understanding of helminth infections in global populations.

Selected speaker from abstracts (only oral presentations are listed): 1993 - 2000


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• The 1st International symposium, New Technologies in Production of Vegetables and Flowers, 1993, Ohrid, Republic of Macedonia. Title: The effect of root-knot nematodes (Meloidogyne spp.) on the morphological characteristics and on the water content of tomato plants in relation to growth.

• 18th Plant Protection Symposium, 1993, Ohrid, Republic of Macedonia. Title: The effect of root-knot nematodes (Meloidogyne spp.) on the dynamic of plant pigments and on the yield of tomato plants.

• 19th Plant Protection Symposium, 1994, Ohrid, Republic of Macedonia. Title: Comparative investigation of tomato changes (Lycopersicon esculentum Mill) caused by phytoparasitic nematodes.

• 18th Tobacco symposium, 1995, Ohrid, Republic of Macedonia. Title: Investigation on the elements dynamic, yield and quality of tobacco infected with root-knot nematodes (Meloidogyne spp.).

• 20th Plant Protection Symposium, 1995, Ohrid, Republic of Macedonia. Title: Morphologic characteristics, content of plant pigments, quality and yield of tobacco infected of root-knot nematodes, Meloidogyne spp.

• 23rd Plant Protection Symposium, November 12 – 15, 1998, Ohrid, Republic of Macedonia. Title: Comparison of classical and contemporary methods for identification of root-knot nematodes, Meloidogyne spp.

• 23rd Conference for Plant Protection, November 10 – 12, 1998, Ohrid, Republic of Macedonia. Title: Comparison of classical and contemporary methods for identification of root-knot nematodes, Meloidogyne spp.

• 51st International Symposium on Crop Protection, May 4, 1999, Gent, Belgium. Title: Variation in mitochondrial DNA in Meloidogyne incognita, M. javanica and M. arenaria.

• Plant Responses to Physical, Chemical and Biotic Constraints, International graduate program workshop, September 22 – 24, 1999, Retzbach, Germany. Title: Variable Number tandem repeats (VNTRs) in mitochondrial DNA of Meloidogyne spp.

• Characterization of endoparasitic nematode secretions, their role in pathogenesis, Spid Meeting, October 10- 15, 1999, Antibes, France, Title: Cell wall degrading enzyme in the root knot nematode Meloidogyne incognita.

2001 - present • APS/SON/MPS Join Meeting, August 24-30, 2001, Salt Lake City, Utah. Title: A novel cell

wall degrading enzyme in the plant parasitic nematode Meloidogyne incognita. • SON annual meeting, July 12-17, 2003, Ithaca, New York. Title: Comparative genomics of

gene expression in parasitic and free-living nematodes. • 45th Annual meeting of the Society of Nematologists, June 18-21, 2006, Kauai, Hawaii.

Title: Nem-fam: a database of coding nematode-specific multi-species conserved sequences.

• ASP&ARC/NHMRC Research Network for Parasitology Annual Conference, July 2-5, 2006, Coast, Queensland, Australia. Title: Identification and characterization of coding nematode-specific multi-species conserved sequences.

• The Biology of Genomes, May 05-09, 2009, CSHL, Cold Spring Harbor, New York. Title: Exploring the human microbiome through whole genome shotgun sequencing and analysis.

• American Society for Tropical Medicine and Hygiene, November 3-7, 2010, Atlanta, Georgia. Title: Pan-phylum analyses of protein-protein interactions reveal potential drug targets for helminthes.


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• Americian Society for Parasitologists, June 26-29, 2013, Quebec City, Canada. Title: Using existing drugs as leads to combat neglected diseases.

• ASTMH 66th Annual Meeting, November 5-9th, 2017, Baltimore, Maryland, USA. Title: Taxonomic and functional microbiome assemblages in Liberian and Indonesian individuals infected with soil-transmitted helminthes.

• ASTMH 67th Annual Meeting, October 28-November 1st 2018, New Orleans, Louisiana, USA. Title: A reverse vaccinology approach for identifying STH vaccine candidates.

RESEARCH SUPPORT: ACTIVE a. Governmental Comparative Genomics of Parasitic Nematodes PI Mitreva (NIH-NIAID; R01 AI081803) Evolution of the Nematode Intestine, A Key Host Interface PI Mitreva (NIH-NIGMS; R01GM097435) Transfer Rule Learning With Functional Mapping For Integrative Modeling of Panomics Data Subcontract-PI Mitreva (NIH-NIGMS; R01GM100387). PI Dr. Gopalakrishnan (U. of Pitsburgh) Common Immune Correlates of Risk of TB disease in Animal Models and Humans Co-Investigator Mitreva (NIH-NIAID; R01AI123780). MPI Dr. Khader (Washington University), Dr. Kaushal (U. of Tulane and Dr. Scriba (U. of Cape Town) Epithelial Responses to Bacterial Invasion Co-Investigator Mitreva (NIH-NIAID; R01AI077600). PI Dr. Miller (Washington University) Genome Sequencing, Assembly, and Annotation of the Gastrointestinal Nematode Trichostrongylus colubriformis PI Mitreva (USDA-ARS; 58-8042-6-100) Identification and validation of mutations causing naturally occurring multi-drug resistance in hookworm Subcontract-PI Mitreva (NIH-NIAID; R21AI137771) PI Dr. Hawdon (George Washington University) Early Life Adversity, Biological Embedding, and Risk for Developmental Precursors of Mental Disorders Co-Investigator Mitreva (NIH/NIMH; R01MH113883). MPI Dr. Luby, Dr. Smyser, Dr. Warner (Washington University) b. Non-governmental Identification, verification and validation of biomarkers and assays for assessing impact of therapy on adult Onchocerca volvulus worms Co-PI Mitreva (DNDi; AIDOAAG1400010). PI Dr. Weil (Washington University)


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PAST: Genomic Dissection of Nematode-Plant Interaction: A Tool to Study Plant Biology Subcontract-PI Mitreva (NSF; NSF-0077503). PI Dr. Bird (North Carolina State University) A Genome Approach to Parasites from the Phylum Nematoda PI Mitreva (NIH-NIAID; U01 46593) Sequencing the Human Microbiome Co-Investigator Mitreva (NIH-Roadmap; U54 HG004968). PI Dr. Wilson (Washington University) A Platform for Large-Scale Genomic Discovery Co-Investigator Mitreva (NIH-NHGRI; U54 HG003079). PI Dr. Wilson (Washington University) PI Mitreva of the following projects: a) Whole genome sequences of nematodes of the order Strongylida b) Anthelmintic resistance in parasitic nematodes c) The genomes of the etiological agents of the Food-Borne Trematodiases d) Genomic diversity among clinical isolates of helminthes

Bioinformatic workshop for helminth genomics PI Mitreva (Amazon Web Services- Amazon Educational Grant) Characterizing the Pan-Nematoda Secretome for Proteins that Activate Innate and Acquired Immunity PI Mitreva (NIFA; 2013-67015-21230) The Molecular Mechanisms By Which Novel Pathogens Emerge Subcontract-PI Mitreva (NSF; 1257685). PI Dr. St. Leger (University of Maryland) Biomarkers of Live Adult Female Onchocerca Volvulus Worm Infection Co-PI Mitreva (BMGF; OPP1083853). MPI Dr. Weil, Dr. Mitreva and Dr. Townsend PATENTS: Pending Invention Disclosure: Case #: 011618 (Anthelmintic drugs, nematocides and drug targets) Pending Invention Disclosure: Case #: 014204 (Antiparasitics based on lysine deacetylase inhibition selective for parasites and not humans) TEACHING AND RELATED RESPONSIBILITIES: 2010 Fifth Annual Research Training Symposium and Poster Session, Poster discussant 2011 M17-553: Bench Fundamentals of Translational Research, The Human Microbiome

(Lecture presenter) 2011 Sixth Annual Research Training Symposium and Poster Session, Poster discussant 2012 Seventh Annual Research Training Symposium and Poster Session, Poster discussant 2013 Eight Annual Research Training Symposium and Poster Session, Poster discussant


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2013 OGR (Opportunity in Genomics Research) post-baccalaureate program. Lecture to recent college graduates that are conducting year-long research in areas of genetics/genomics

2014 Global Health & Infectious Disease Conference, Judge – Trainee Oral Symposium 2014 Ninth Annual Research Training Symposium and Poster Session, Poster discussant 2015 Molecular Microbiology/Infectious Diseases program – Infectious Diseases Gateway

course 2015 Tenth Annual Research Training Symposium and Poster Session, Poster discussant 2015 Global Health & Infectious Disease Conference, Judge – Trainee Oral Symposium 2016 Eleventh Annual Research Training Symposium and Poster Session, Poster discussant 2018 Global Health & Infectious Disease Conference, Judge – Trainee Poster Reviewer 2018 Thirteen Annual Research Training Symposium and Poster Session, Poster discussant 2018 Bayer fellowship committee 2018 Qualifying examination committee (Elizabeth Kennedy, DBBS/MMMP program,

Baldridge lab) TRAINING / MENTEE RECORD: Current Trainees / Mentees Thesis advisor and Examination Committee member: 2014-present Lindsay Parnell, DBBS/MGG program PhD candidate 2018-present Dennis Zhu, DBBS/PMB program PhD candidate 2018-present Chivonne Moodley, Biomedical Sciences PhD candidate, Tulane

University Medical School Training of postdoctoral fellows: 2013-present Young-Jun Choi, PhD Supporting/Mentoring junior WUSM physicians/faculty: 2014- William McCoy, Willian, MD, PhD (Instructor; Dermatology, DOM, BJH) 2016- Matthew Kuhlmann, MD, PhD (Instructor; ID, DOM) 2017- Soumya Chatterjee, MD (Assistant Professor, Departments of Internal Medicine

& Molecular Microbiology, SLU) Past Trainees / Mentees Thesis advisor and Examination Committee member: 2009-2011 Xin Gao, PhD candidate, George Washington University Medical Center 2007-2011 Samantha N. McNulty, MMMP PhD candidate, ID Division, DOM, WUSM 2012-2016 Jie Zhang, PhD candidate, Oncology Division, DOM, WUSM 2014-2018 Britt Anderson, MMMP MD PhD candidate, ID Division, DOM, WUSM 2016-2017 Elaine Otchere, MA/MD candidate, ID Division/MGI, DOM, WUSM Training of postdoctoral fellows: 2004-2007 Yong Yin, PhD 2007-2010 Zhengyuan Wang, PhD 2010-2012 Esley Heizer, PhD 2011-2013 Yat T. Tang, PhD 2012-2014 Bruce Rosa, PhD


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2011-2015 Xin Gao, PhD 2013-2016 Samantha N. McNulty, PhD 2011-2016 Rahul Tyagi, PhD Training of undergraduate/graduate students and visiting scientists: 2013 Esha Jain (MS in Bioinformatics, Georgia Institute of Technology) 2013 Jess Millar (B.S. in Biology: Micro/Molecular, Portland State University) 2013 Yenny Djuardi, MD, PhD (Faculty of Medicine, University of Indonesia) 2014 Darius Bost (B.S. in Applied Mathematics, North Carolina A&T State University) 2014 Lucja Labuda (PhD student, LUMC, Leiden, The Netherlands) 2014 Michael Guzman (PhD Student, rotation student WUSM) 2015 Britt Anderson (MD PhD Student, rotation student WUSM) 2015 Jose Dylan Sosa (Junior, St. Edward’s University, Austin, TX) 2016 Yanyan Jian, (MD PHD, Chinese CDC, Shanghai, China) 2018 Caroline Snowden (MD Student, WUSM) 2018 Blagorodna Partikova (MSc Student, intern Ludwig-Maximilians University,

Munchen, Germany) 2018 Keerthana Chintalapati (Undergraduate, Washington University in St. Louis) 2018 Hyeim Jung (PhD Student, rotation student WUSM) BIBLIOGRAPHY: Peer reviewed manuscripts: h-index=49, i10-index=118 (Google Scholar: https://scholar.google.ca/citations?user=OpKySvwAAAAJ&hl=en) 1. Dautova M, Spasenovski M, Vuckov R, The effect of root-knot nematodes (Meloidogyne

spp.) on the morphological characteristics and on the water content of tomato plants in relation to growth. Faculty of Agriculture Review of Works 1994: 275-282.

2. Dautova M, Spasenovski M, Vuckov R, The effect of root-knot nematodes (Meloidogyne spp.) on the dynamic of plant pigments and on the yield of tomato plants. Yearbook for plant protection 1994: 5: 149-156.

3. Dautova M, Spasenovski M, Vuckov R, Comparative investigation of tomato changes (Lycopersicon esculentum Mill) caused by phytoparasitic nematodes. Yearbook for plant protection 1995: 6: 141-148.

4. Trpeski V, Kocevski V, Jekic M, Jakimov D, Dautova M, The effect of organic and mineral fertilisers on yield and quality of pepper cv Kurtovska Kapija, Yearbook of the Faculty of Agriculture 1995: 40: 115-122.

5. Dautova M, Spasenovski M, Vuckov R, Morphologic characteristics, content of plant pigments, quality and yield of tobacco infected with root-knot nematodes, Meloidogyne spp. Yearbook for plant protection 1996: 7: 37-47.

6. Dautova M, Pelivanoska V, Vuckov R, Investigation on the elements dynamic, yield and quality of tobacco infected with root-knot nematodes (Meloidogyne spp.). Tobacco 1997: 47: 88-99.

7. Dautova M, Pejcinovski F, Comparison of classical and contemporary methods for identification of root-knot nematodes, Meloidogyne spp. Yearbook for plant protection 1999: 9: 173-183.

8. Dautova M, Gommers FJ, Meloidogyne spp. in Macedonia: Distribution and virulence for Mi resistance in tomato. Nematologia Mediterranea 2000: 28: 121-128.


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9. Dautova M, Rosso MN, Abad P, Gommers FJ, Bakker J, Smant G. Single pass cDNA sequencing – a powerful tool to analyse gene expression in preparasitic juveniles of the southern root-knot nematode Meloidogyne incognita. Nematology 2001: 3: 129-139.

10. Dautova M, Overmars H, Bakker J, Smant G, Gommers FJ, Nuclear and mitochondrial DNA polymorphism of root-knot nematodes Meloidogyne spp. European Journal of Plant Pathology 2002: 108: 209-220.

11. McCarter JP, Mitreva-Dautova M, Martin J, Dante M, Wylie T, Rao U, Pape D, Bowers Y, Theising B, Murphy CV, Kloek AP, Chiapelli BJ, Clifton SW, Bird DM, Waterston RH, Analysis and functional classification of transcripts from the nematode Meloidogyne incognita. Genome Biol. 2003: 4(4): R26; PubMed PMID: 19262781; PubMed Central PMCID: PMC2620685.

12. Wylie T, Martin JC, Dante M, Mitreva MD, Clifton SW, Chinwalla A, Waterston RH, Wilson RK, McCarter JP, Nematode.net: a tool for navigating sequences from parasitic and free-living nematodes. Nucleic Acids Res. 2004: 32: D423-6; PubMed PMID: 14681448; PubMed Central PMCID: PMC308745.

13. Mitreva M, McCarter JP, Martin J, Dante M, Wylie T, Chiapelli B, Pape D, Clifton SW, Nutman TB, Waterston RH, Comparative genomics of gene expression in the parasitic and free-living nematodes Strongyloides stercoralis and Caenorhabditis elegans. Genome Res. 2004: 14(2): 209-20; PubMed PMID: 14762059;PubMed Central PMCID: PMC327096.

14. Mitreva M, Elling AA, Dante M, Kloek AP, Kalyanaraman A, Aluru S, Clifton SW, Bird DM, Baum TJ, McCarter JP, A survey of SL1-spliced transcripts from the root-lesion nematode Pratylenchus penetrans. Mol Genet Genomics. 2004: 272(2): 138-48; PubMed PMID: 15338281.

15. Mitreva M, Jasmer DP, Appleton J, Martin J, Dante M, Wylie T, Clifton SW, Waterston RH, McCarter JP, Gene discovery in the adenophorean nematode Trichinella spiralis: an analysis of transcription from three life cycle stages. Mol Biochem Parasitol. 2004: 137(2): 277-91; PubMed PMID: 15383298.

16. Jasmer DP, Mitreva MD, McCarter JP, mRNA sequences for Haemonchus contortus intestinal cathepsin B-like cysteine proteases display an extreme in abundance and diversity compared with other adult mammalian parasitic nematodes. Mol Biochem Parasitol. 2004: 137(2): 297-305; PubMed PMID: 15383300.

17. Parkinson J, Mitreva M, Whitton C, Thomson M, Daub J, Martin J, Schmid R, Hall N, Barrell B, Waterston RH, McCarter JP, Blaxter ML, A transcriptomic analysis of the phylum Nematoda. Nat Genet. 2004: 36(12): 1259-67; PubMed PMID: 15543149.

18. Mitreva M, McCarter JP, Arasu P, Hawdon J, Martin J, Dante M, Wylie T, Xu J, Stajich JE, Kapulkin W, Clifton SW, Waterston RH, Wilson RK, Investigating hookworm genomes by comparative analysis of two Ancylostoma species. BMC Genomics 2005: 6(1): 58; PubMed PMID: 15854223; PubMed Central PMCID:PMC1112591.

19. Thompson FJ, Mitreva M, Barker GL, Martin J, Waterston RH, McCarter JP, Viney ME, An expressed sequence tag analysis of the life-cycle of the parasitic nematode Strongyloides ratti. Mol Biochem Parasitol. 2005: 142(1): 32-46; PubMed PMID: 15907559.

20. Li BW, Rush AC, Crosby SD, Warren WC, Williams SA, Mitreva M, Weil GJ, Profiling of gender-regulated gene transcripts in the filarial nematode Brugia malayi by cDNA oligonucleotide array analysis. Mol Biochem Parasitol. 2005: 143(1): 49-57; PubMed PMID: 15992941.

21. van Herpen TW, Goryunova SV, van der Schoot J, Mitreva M, Salentijn E, Vorst O, Schenk MF, van Veelen PA, Koning F, van Soest LJ, Vosman B, Bosch D, Hamer RJ, Gilissen LJ, Smulders MJ, Alpha-gliadin genes from the A, B, and D genomes of wheat contain different


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sets of celiac disease epitopes. BMC Genomics. 2006: 7: 1; PubMed PMID: 16403227; PubMed Central PMCID: PMC1368968.

22. Vanholme B, Mitreva M, Van Criekinge W, Logghe M, Bird D, McCarter JP, Gheysen G, Detection of putative secreted proteins in the plant-parasitic nematode Heterodera schachtii. Parasitol Res. 2006: 98(5): 414-24; PubMed PMID: 16380840.

23. Mitreva-Dautova M, Roze E, Overmars H, de Graaff L, Schots A, Helder J, Goverse A, Bakker J, Smant G, A symbiont-independent endo-1,4-beta-xylanase from the plant-parasitic nematode Meloidogyne incognita. Mol Plant Microbe Interact. 2006: 19(5): 521-9; PMID: 16673939.

24. Yin Y, Martin J, McCarter JP, Clifton SW, Wilson RK, Mitreva M, Identification and analysis of genes expressed in the adult filarial parasitic nematode Dirofilaria immitis. Int J Parasitol. 2006: 36(7): 829-39; PubMed PMID: 16697384.

25. Mitreva M, Wendl MC, Martin J, Wylie T, Yin Y, Larson A, Parkinson J, Waterston RH, McCarter JP, Codon usage patterns in Nematoda: analysis based on over 25 million codons in thirty-two species. Genome Biol. 2006: 7(8): R75.

26. Li BW, Rush AC, Weil GJ, McCarter JP, Mitreva M. Brugia malayi: effects of radiation and culture on gene expression in infective larvae. Mol Biochem Parasitol. 2006: 149(2): 201-7; PubMed PMID: 16824625.

27. Elling AA, Mitreva M, Recknor J, Gai X, Martin J, Maier TR, McDermott JP, Hewezi T, McK Bird D, Davis EL, Hussey RS, Nettleton D, McCarter JP, Baum TJ, Divergent evolution of arrested development in the dauer stage of Caenorhabditis elegans and the infective stage of Heterodera glycines. Genome Biol. 2007: 8(10): R211; PubMed PMID: 17919324; PubMed Central PMCID: PMC2246285.

28. Ghedin E, Wang S, Spiro D, Caler E, Zhao Q, Crabtree J, Allen JE, Delcher AL, Guiliano DB, Miranda-Saavedra D, Angiuoli SV, Creasy T, Amedeo P, Haas B, El-Sayed NM, Wortman JR, Feldblyum T, Tallon L, Schatz M, Shumway M, Koo H, Salzberg SL, Schobel S, Pertea M, Pop M, White O, Barton GJ, Carlow CK, Crawford MJ, Daub J, Dimmic MW, Estes CF, Foster JM, Ganatra M, Gregory WF, Johnson NM, Jin J, Komuniecki R, Korf I, Kumar S, Laney S, Li BW, Li W, Lindblom TH, Lustigman S, Ma D, Maina CV, Martin DM, McCarter JP, McReynolds L, Mitreva M, Nutman TB, Parkinson J, Peregrín-Alvarez JM, Poole C, Ren Q, Saunders L, Sluder AE, Smith K, Stanke M, Unnasch TR, Ware J, Wei AD, Weil G, Williams DJ, Zhang Y, Williams SA, Fraser-Liggett C, Slatko B, Blaxter ML, Scott AL. Draft genome of the filarial nematode parasite Brugia malayi. Science 2007: 317(5845): 1756-60; PubMed PMID: 17885136; PubMed Central PMCID: PMC2613796.

29. Laha T, Loukas A, Wattanasatitarpa S, Somprakhon J, Kewgrai N, Sithithaworn P, Kaewkes S, Mitreva M, Brindley PJ, The bandit, a New DNA Transposon from a Hookworm-Possible Horizontal Genetic Transfer between Host and Parasite. PLoS Negl Trop Dis. 2007: 1(1): e35; PubMed PMID: 17989781; PubMed Central PMCID: PMC2041818.

30. Roze E, Hanse B, Mitreva M, Vanholme B, Bakker J, Smant G, Mining the secretome of the root-knot nematode Meloidogyne chitwoodi for candidate parasitism genes. Mol Plant Pathol. 2008: 9(1): 1-10; PubMed PMID: 18705879.

31. Abubucker S, Martin J, Yin Y, Fulton L, Yang SP, Hallsworth-Pepin K, Johnston JS, Hawdon J, McCarter JP, Wilson RK, Mitreva M. The canine hookworm genome: analysis and classification of Ancylostoma caninum survey sequences. Mol Biochem Parasitol. 2008: 157(2): 187-92; PubMed PMID: 18082904; PubMed Central PMCID: PMC2265417.

32. Warren WC, Hillier LW, Marshall Graves JA, Birney E, Ponting CP, Grützner F, Belov K, Miller W, Clarke L, Chinwalla AT, Yang SP, Heger A, Locke DP, Miethke P, Waters PD,


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Veyrunes F, Fulton L, Fulton B, Graves T, Wallis J, Puente XS, López-Otín C, Ordóñez GR, Eichler EE, Chen L, Cheng Z, Deakin JE, Alsop A, Thompson K, Kirby P, Papenfuss AT, Wakefield MJ, Olender T, Lancet D, Huttley GA, Smit AF, Pask A, Temple-Smith P, Batzer MA, Walker JA, Konkel MK, Harris RS, Whittington CM, Wong ES, Gemmell NJ, Buschiazzo E, Vargas Jentzsch IM, Merkel A, Schmitz J, Zemann A, Churakov G, Kriegs JO, Brosius J, Murchison EP, Sachidanandam R, Smith C, Hannon GJ, Tsend-Ayush E, McMillan D, Attenborough R, Rens W, Ferguson-Smith M, Lefèvre CM, Sharp JA, Nicholas KR, Ray DA, Kube M, Reinhardt R, Pringle TH, Taylor J, Jones RC, Nixon B, Dacheux JL, Niwa H, Sekita Y, Huang X, Stark A, Kheradpour P, Kellis M, Flicek P, Chen Y, Webber C, Hardison R, Nelson J, Hallsworth-Pepin K, Delehaunty K, Markovic C, Minx P, Feng Y, Kremitzki C, Mitreva M, Glasscock J, Wylie T, Wohldmann P, Thiru P, Nhan MN, Pohl CS, Smith SM, Hou S, Nefedov M, de Jong PJ, Renfree MB, Mardis ER, Wilson RK, Genome analysis of the platypus reveals unique signatures of evolution. Nature 2008: 453(7192): 175-83; PubMed PMID: 18464734; PubMed Central PMCID: PMC2803040.

33. Jacob J, Mitreva M, Vanholme B, Gheysen G, Exploring the transcriptome of the burrowing nematode Radopholus similis. Mol Genet Genomics. 2008: 280(1):1-17; PubMed PMID: 18386064.

34. Yin Y, Martin J, Abubucker S, Scott AL, McCarter JP, Wilson RK, Jasmer DP, Mitreva M, Intestinal Transcriptomes of Nematodes: Comparison of the Parasites Ascaris suum and Haemonchus contortus with the Free-living Caenorhabditis elegans. PLoS Negl Trop Dis. 2008: 2(8): e269; PubMed PMID: 18682827; PubMed Central PMCID: PMC2483350.

35. Dieterich C, Clifton SW, Schuster LN, Chinwalla A, Delehaunty K, Dinkelacker I, Fulton L, Fulton R, Godfrey J, Minx P, Mitreva M, Roeseler W, Tian H, Witte H, Yang SP, Wilson RK, Sommer RJ, The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism. Nat Genet. 2008: 40(10): 1193-8; PubMed PMID: 18806794.

36. Wylie T, Martin J, Abubucker S, Yin Y, Messina D, Wang Z, McCarter JP, Mitreva M, NemaPath: online exploration of KEGG-based metabolic pathways for nematodes. BMC Genomics 2008: 9: 525; PubMed PMID: 18983679; PubMed Central PMCID: PMC2588608.

37. Martin J, Abubucker S, Wylie T, Yin Y, Wang Z, Mitreva M, Nematode.net update 2008: improvements enabling more efficient data mining and comparative nematode genomics. Nucleic Acids Res. 2009: 37(Database issue): D571-8; PubMed PMID: 18940860; PubMed Central PMCID: PMC2686480.

38. Wang Z, Martin J, Abubucker S, Yin Y, Gasser RB, Mitreva M, Systematic analysis of insertions and deletions specific to nematode proteins and their proposed functional and evolutionary relevance. BMC Evol Biol. 2009: 9: 23; PubMed PMID: 19175938; PubMed Central PMCID: PMC2644674.

39. Elling AA, Mitreva M, Gai X, Martin J, Recknor J, Davis EL, Hussey RS, Nettleton D, McCarter JP, Baum TJ, Sequence mining and transcript profiling to explore cyst nematode parasitism. BMC Genomics 2009: 10: 58; PubMed PMID: 19183474; PubMed Central PMCID: PMC2640417.

40. Zarlenga DS, Rosenthal B, Hoberg E, Mitreva M, Integrating genomics and phylogenetics in understanding the history of Trichinella species. Vet Parasitol. 2009: 159(3-4): 210-3; PubMed PMID: 19046815.

41. Yin Y, Martin J, Abubucker S, Wang Z, Wyrwicz L, Rychlewski L, McCarter JP, Wilson RK, Mitreva M, Molecular determinants archetypical to the phylum Nematoda. BMC Genomics 2009: 10: 114; PubMed PMID: 19296854; PubMed Central PMCID: PMC2666764.


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42. Abubucker S, Zarlenga DS, Martin J, Yin Y, Wang Z, McCarter JP, Gasbarree L, Wilson RK, Mitreva M, The transcriptomes of the cattle parasitic nematode Ostertagia ostartagi. Vet Parasitol. 2009: 162(1-2): 89-99; PubMed PMID: 19346077; PubMed Central PMCID: PMC2677129.

43. Li BW, Rush AC, Mitreva M, Yin Y, Spiro D, Ghedin E, Weil GJ, Transcriptomes and pathways associated with infectivity, survival and immunogenicity in Brugia malayi L3. BMC Genomics 2009: 10: 267; PubMed PMID: 19527522; PubMed Central PMCID: PMC2708187.

44. Haegeman A, Jacob J, Vanholme B, Kyndt T, Mitreva M, Gheysen G, Expressed sequence tags of the peanut pod nematode Ditylenchus africanus: the first transcriptome analysis of an Anguinid nematode. Mol Biochem Parasitol. 2009: 167(1): 32-40; PubMed PMID: 19383517; PubMed Central PMCID: PMC2694848.

45. Hao YJ, Montiel R, Abubucker S, Mitreva M, Simões N, Transcripts analysis of the entomopathogenic nematode Steinernema carpocapsae induced in vitro with insect haemolymph. Mol Biochem Parasitol. 2009: 10: 267; PMID: 19836423.

46. Wang Z, Abubucker S, Martin J, Wilson RK, Hawdon J, Mitreva M. Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation. BMC Genomics. 2010: 11:307. PubMed PMID: 20470405; PubMed Central PMCID: PMC2882930.

47. Cantacessi C, Mitreva M, Jex AR, Young ND, Campbell BE, Hall RS, Doyle MA, Ralph SA, Rabelo EM, Ranganathan S, Sternberg PW, Loukas A, Gasser RB. Massively parallel sequencing and analysis of the Necator americanus transcriptome. PLoS Negl Trop Dis. 2010: 4(5):e684. PubMed PMID: 20485481; PubMed Central PMCID: PMC2867931.

48. Human Microbiome Jumpstart Reference Strains Consortium, Nelson KE, Weinstock GM, Highlander SK, Worley KC, Creasy HH, Wortman JR, Rusch DB, Mitreva M, Sodergren E, Chinwalla AT, Feldgarden M, Gevers D, Haas BJ, Madupu R, Ward DV, Birren BW, Gibbs RA, Methe B, Petrosino JF, Strausberg RL, Sutton GG, White OR, Wilson RK, Durkin S, Giglio MG, Gujja S, Howarth C, Kodira CD, Kyrpides N, Mehta T, Muzny DM, Pearson M, Pepin K, Pati A, Qin X, Yandava C, Zeng Q, Zhang L, Berlin AM, Chen L, Hepburn TA, Johnson J, McCorrison J, Miller J, Minx P, Nusbaum C, Russ C, Sykes SM, Tomlinson CM, Young S, Warren WC, Badger J, Crabtree J, Markowitz VM, Orvis J, Cree A, Ferriera S, Fulton LL, Fulton RS, Gillis M, Hemphill LD, Joshi V, Kovar C, Torralba M, Wetterstrand KA, Abouellleil A, Wollam AM, Buhay CJ, Ding Y, Dugan S, FitzGerald MG, Holder M, Hostetler J, Clifton SW, Allen-Vercoe E, Earl AM, Farmer CN, Liolios K, Surette MG, Xu Q, Pohl C, Wilczek-Boney K, Zhu D. A catalog of reference genomes from the human microbiome. Science. 2010; 328(5981):994-9. PubMed PMID: 20489017.

49. McNulty SN, Foster JM, Mitreva M, Dunning Hotopp JC, Martin J, Fischer K, Wu B, Davis PJ, Kumar S, Brattig NW, Slatko BE, Weil GJ, Fischer PU. Endosymbiont DNA in endobacteria-free filarial nematodes indicates ancient horizontal genetic transfer. PLoS One. 2010: 5(6):e11029. PubMed PMID: 20543958; PubMed Central PMCID: PMC2882956.

50. Cantacessi C, Jex AR, Hall RS, Young ND, Campbell BE, Joachim A, Nolan MJ, Abubucker S, Sternberg PW, Ranganathan S, Mitreva M, Gasser RB. A practical, bioinformatic workflow system for large data sets generated by next-generation sequencing. Nucleic Acids Res. 2010 Aug 3. PubMed PMID: 20682560.

51. Severance S, Rajagopal A, Rao AU, Cerqueira GC, Mitreva M, El-Sayed NM, Krause M, Hamza I. Genome-wide analysis reveals novel genes essential for heme homeostasis in


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Caenorhabditis elegans. PLoS Genet. 2010: 6(7):e1001044. PubMed PMID: 20686661; PubMed Central PMCID: PMC2912396.

52. Cantacessi C, Mitreva M, Campbell BE, Hall RS, Young ND, Jex AR, Ranganathan S, Gasser RB. First transcriptomic analysis of the economically important parasitic nematode, Trichostrongylus colubriformis, using a next-generation sequencing approach. Infect Genet Evol. 2010 Aug 6. PubMed PMID: 20692378.

53. Gao X, Wang Z, Martin J, Abubucker S, Zhang X, Mitreva M, Hawdon JM. Identification of hookworm DAF-16/FOXO response elements and direct gene targets. PLoS One. 2010: 5(8). PubMed PMID: 20808816; PubMed Central PMCID: PMC2924398.

54. Camilla M. Whittington CM2, Papenfuss AT, Locke DP, Mardis ER, Wilson RK, Abubucker S, Mitreva M, Wong ESW, Hsu AL, Kuchel PW, Belov K, Warren WC, Novel venom gene discovery in the platypus, Genome Biology 2010, 11(9):R95; PubMed Central PMID: 20920228.

55. Cantacessi C, Gasser RB, Strube C, Schnieder T, Jex AR, Hall RS, Campbell BE, Young ND, Ranganathan S, Sternberg PW, and Mitreva M. Deep insights into Dictyocaulus viviparus transcriptomes provides unique prospects for new drug targets and disease intervention. Biotechnology Advances, 2011, 29(3):261-71. PubMed PMID: 21182926.

56. Locke DP, Hillier LW, Warren WC, Worley KC, Nazareth LV, Muzny DM, Yang SP, Wang Z, Chinwalla AT, Minx P, Mitreva M, Cook L, Delehaunty KD, Fronick C, Schmidt H, Fulton LA, Fulton RS, Nelson JO, Magrini V, Pohl C, Graves TA, Markovic C, Cree A, Dinh HH, Hume J, Kovar CL, Fowler GR, Lunter G, Meader S, Heger A, Ponting CP, Marques-Bonet T, Alkan C, Chen L, Cheng Z, Kidd JM, Eichler EE, White S, Searle S, Vilella AJ, Chen Y, Flicek P, Ma J, Raney B, Suh B, Burhans R, Herrero J, Haussler D, Faria R, Fernando O, Darré F, Farré D, Gazave E, Oliva M, Navarro A, Roberto R, Capozzi O, Archidiacono N, Della Valle G, Purgato S, Rocchi M, Konkel MK, Walker JA, Ullmer B, Batzer MA, Smit AF, Hubley R, Casola C, Schrider DR, Hahn MW, Quesada V, Puente XS, Ordoñez GR, López-Otín C, Vinar T, Brejova B, Ratan A, Harris RS, Miller W, Kosiol C, Lawson HA, Taliwal V, Martins AL, Siepel A, Roychoudhury A, Ma X, Degenhardt J, Bustamante CD, Gutenkunst RN, Mailund T, Dutheil JY, Hobolth A, Schierup MH, Ryder OA, Yoshinaga Y, de Jong PJ, Weinstock GM, Rogers J, Mardis ER, Gibbs RA, Wilson RK. Comparative and demographic analysis of orang-utan genomes. Nature. 2011 Jan 27;469(7331):529-33. PubMed PMID: 21270892; PubMed Central PMCID: PMC3060778.

57. Li BW, Rush AC, Jiang DJ, Mitreva M, Abubucker S, Weil GJ. Gender-associated genes in filarial nematodes are important for reproduction and potential intervention targets. PLoS Negl Trop Dis. 2011 Jan 25;5(1):e947. PubMed PMID: 21283610; PubMed Central PMCID: PMC3026763.

58. Mitreva M, Jasmer DP, Zarlenga DS, Wang Z, Abubucker S, Martin J, Taylor CM, Yin Y, Fulton L, Minx P, Yang SP, Warren WC, Fulton RS, Bhonagiri V, Zhang X, Hallsworth-Pepin K, Clifton SW, McCarter JP, Appleton J, Mardis ER, Wilson RK. The draft genome of the parasitic nematode Trichinella spiralis. Nat Genet. 2011 Mar;43(3):228-35. Epub 2011 Feb 20. PubMed PMID: 21336279; PubMed Central PMCID: PMC3057868.

59. Ye L, Hillier LW, Minx P, Thane N, Locke D, Martin JC, Chen L, Mitreva M, Miller JR, Haub KV, Dooling D, Mardis ER, Wilson RK, Weinstock GM, Warren WC. A vertebrate case study of the quality of assemblies derived from next-generation sequences. Genome Biol. 2011 Mar 31;12(3):R31. PubMed PMID: 21453517.

60. Zhang Z, Wang Y, Wang S, Liu J, Warren W, Mitreva M, Walter RB. Transcriptome Analysis of Female and Male Xiphophorus maculatus Jp 163 A. PLoS One. 2011 Apr 5;6(4):e18379. PubMed PMID: 21483681; PubMed Central PMCID: PMC3071723.


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61. Taylor CM, Fischer K, Abubucker S, Wang Z, Martin J, Jiang D, Magliano M, Rosso MN, Li BW, Fischer PU, Mitreva M. Targeting protein-protein interactions for parasite control. PLoS One. 2011 Apr 27;6(4):e18381. PubMed PMID: 21556146; PubMed Central PMCID: PMC3083401.

62. Dalzell JJ, McVeigh P, Warnock ND, Mitreva M, Bird DM, Abad P, Fleming CC, Day TA, Mousley A, Marks NJ, Maule AG. RNAi effector diversity in nematodes. PLoS Negl Trop Dis. 2011 Jun;5(6):e1176. PubMed PMID: 21666793; PubMed Central PMCID: PMC3110158.

63. Wang J, Czech B, Crunk A, Wallace A, Mitreva M, Hannon GJ, Davis RE. Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles. Genome Res. 2011 Jul 25. PubMed PMID: 21685128.

64. Abubucker S, Martin J, Taylor CM, Mitreva M. HelmCoP: An Online Resource for Helminth Functional Genomics and Drug and Vaccine Targets Prioritization. PLoS One. 2011;6(7):e21832. Epub 2011 Jul 8. PubMed PMID: 21760913; PubMed Central PMCID: PMC3132748.

65. Younis AE, Geisinger F, Ajonina-Ekoti I, Soblik H, Steen H, Mitreva M, Erttmann KD, Perbandt M, Liebau E, Brattig NW. Stage-specific excretory/secretory small heat shock proteins from the parasitic nematode Strongyloides ratti: putative links to host's intestinal mucosal defense system. FEBS J. 278(18):3319-36. PubMed PMID: 21762402.

66. Martin J, Abubucker S, Heizer E, Taylor CM, Mitreva M. Nematode.net update 2011: addition of data sets and tools featuring next-generation sequencing data. Nucleic Acids Res. 2012 Jan;40(Database issue):D720-8. Epub 2011 Dec 1. PubMed PMID: 22139919; PubMed Central PMCID: PMC3245159.

67. Soblik H, Younis AE, Mitreva M, Renard BY, Kirchner M, Geisinger F, Steen H, Brattig NW. Life cycle stage-resolved proteomic analysis of the excretome/secretome from Strongyloides ratti--identification of stage-specific proteases. Mol Cell Proteomics. 2011 Dec;10(12):M111.010157. Epub 2011 Sep 30. PubMed PMID: 21964353.

68. Rao RU, Huang Y, Abubucker S, Heinz M, Crosby SD, Mitreva M, Weil GJ. Effects of doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo. J Biomed Sci. 2012 Feb 9;19:21. PubMed PMID: 22321609; PubMedCentral PMCID: PMC3352068.

69. Li BW, Wang Z, Rush AC, Mitreva M, Weil GJ. Transcription profiling reveals stage- and function-dependent expression patterns in the filarial nematode Brugia malayi. BMC Genomics. 2012 May 14;13:184. PubMed PMID: 22583769; PubMed Central PMCID: PMC3414817.

70. Human Microbiome Project Consortium. A framework for human microbiome research. Nature. 2012 Jun 13;486(7402):215-21. PubMed PMID: 22699610; PubMed Central PMCID: PMC3377744.

71. Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012 Jun 13;486(7402):207-14. Doi: 10.1038/nature11234. PubMed PMID: 22699609.

72. Abubucker S, Segata N, Goll J, Schubert AM, Izard J, Cantarel BL, Rodriguez-Mueller B, Zucker J, Thiagarajan M, Henrissat B, White O, Kelley ST, Methé B, Schloss PD, Gevers D, Mitreva M, Huttenhower C. Metabolic reconstruction for metagenomic data and its application to the human microbiome. PLoS Comput Biol. 2012 Jun;8(6):e1002358. Epub 2012 Jun 13. PubMed PMID: 22719234; PubMed Central PMCID: PMC3374609.

73. Martin J, Sykes S, Young S, Kota K, Sanka R, Sheth N, Orvis J, Sodergren E, Wang Z, Weinstock GM, Mitreva M. Optimizing read mapping to reference genomes to determine


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composition and species prevalence in microbial communities. PLoS One. 2012;7(6):e36427. Epub 2012 Jun 13. PubMed PMID: 22719831; PubMed Central PMCID: PMC3374613.

74. Wang Z, Zarlenga D, Martin J, Abubucker S, Mitreva M. Exploring metazoan evolution through dynamic and holistic changes in protein families and domains. BMC Evol Biol. 2012 Aug 3;12(1):138. PubMed PMID: 22862991.

75. McNulty SN, Abubucker S, Simon GM, Mitreva M, McNulty NP, Fischer K, Curtis KC, Brattig NW, Weil GJ, Fischer PU. Transcriptomic and Proteomic Analyses of a Wolbachia-Free Filarial Parasite Provide Evidence of Trans-Kingdom Horizontal Gene Transfer. PLoS One, 2012;7(9):e45777. PubMed PMID: 23049857; PubMed Central PMCID: PMC3458923.

76. Wendl MC, Kota K, Weinstock GM, and Mitreva M. A sampling theory for metagenomic DNA sequencing based on a generalization of Stevens’ theorem, J Math Biol. 2012 Sep 11. PubMed PMID: 22965653.

77. Wang J, Mitreva M, Berriman M, Thorne A, Magrini V, Koutsovoulos G, Kumar S, Blaxter ML, and Davis RE. Germline Silencing of Germline-Expressed Genes by DNA Elimination in Somatic Cells, Developmental Cell, November 1, 2012, 10.1016/j.devcel.2012.09.020.

78. Schloissnig S, Arumugam M, Sunagawa S, Mitreva M, Tap J, Zhu A, Waller A, Mende D, Martin J, Kota K, Sunyaev SR, Weinstock GM and Bork P. Genomic variation landscape of the human gut microbiome: Individuality and temporal stability, Nature, 2013 Jan 3;493(7430):45-50. PubMed PMID:23222524; PubMed Central PMCID: PMC3536929.

79. Pavan MG, Mesquita RD, Lawrence GG, Lazoski C, Dotson EM, Abubucker S, Mitreva M, Randall-Maher J, Monteiro FA. A nuclear single-nucleotide polymorphism (SNP) potentially useful for the separation of Rhodnius prolixus from members of the Rhodnius robustus cryptic species complex (Hemiptera: Reduviidae). Infect Genet Evol. 2013 Mar;14:426-33. PubMed PMID: 23219914.

80. De Graeff J, Demeler J, Skuce P, Mitreva M, von Samson-Himmelstjerna G, Vercruysse J, Claerbout E and P Geldhof. Gene transcription analysis of ABC transporters in a resistant Cooperia oncophora isolate following in vivo and in vitro exposure to macrocyclic lactones. Parasitology 2013 Jan 2:1-10. PubMed PMID: 23279803; PubMed Central PMCID: PMC3690601.

81. Lozupone C, Cota-Gomez A, Palmer BE, Linderman DJ, Charlson ES, Sodergren E, Mitreva M, Abubucker S, Martin J, Yao G, Campbell TB, Flores SC, Ackerman G, Stombaugh J, Ursell L, Beck JM, Curtis JL, Young VB, Lynch SV, Huang L, Weinstock GM, Knox KS, Twigg H, Morris A, Ghedin E, Bushman FD, Collman RG, Knight R, Fontenot AP; for the Lung HIV Microbiome Project. Widespread Colonization of the Lung by Tropheryma whipplei in HIV Infection. Am J Respir Crit Care Med. 2013 May 15;187(10):1110-7. PubMed PMID: 23392441; PubMed Central PMCID: PMC3734615.

82. Heizer E, Zarlenga DS, Gasser RB, De Graef J, Geldhof P and Mitreva M. Transcriptome analyses reveal protein and domain families that delineate stage-related development in the economically important parasitic nematodes, Ostertagia ostertagi and Cooperia oncophora, BMC Genomics, 2013 Feb 22;14:118. doi: 10.1186/1471-2164-14-118. PubMed PMID: 23432754; PubMed Central PMCID: PMC3599158.

83. Taylor CM, Martin J, Rao RU, Powell K, Abubucker S, Mitreva M. Using existing drugs as leads for broad spectrum anthelmintics targeting protein kinases. PLoS Pathog. 2013 Feb;9(2):e1003149. PubMed PMID: 23459584; PubMed Central PMCID: PMC3573124.

84. Wang Z, Gao X, Martin J, Yin Y, Abubucker S, Rash AC, Li BW, Nash B, Hallsworth-Pepin K, Jasmer DP, Mitreva M. Gene expression analysis distinguishes tissue-specific and


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gender-related functions among adult Ascaris suum tissues. Mol Genet Genomics. 2013 Jun;288(5-6):243-60. PubMed PMID: 23572074; PubMed Central PMCID: PMC3670759.

85. Ondrovics M, Silbermayr K, Mitreva M, Young ND, Razzazi-Fazeli E, Gasser RB, Joachim A. Proteomic analysis of Oesophagostomum dentatum (Nematoda) during larval transition, and the effects of hydrolase inhibitors on development. PLoS One. 2013 May 22;8(5):e63955. PubMed PMID: 23717515; PubMed Central PMCID: PMC3661580.

86. Cantacessi C, Hofmann A, Pickering D, Navarro S, Mitreva M, Loukas A. TIMPs of parasitic helminths - a large-scale analysis of high-throughput sequence datasets. Parasit Vectors. 2013 May 30;6:156. PubMed PMID: 23721526; PubMed Central PMCID: PMC3679795.

87. Borloo J, Peelaers I, De Graef J, Devreese B, Hokke CH, Mitreva M, Claerebout E, Vercruysse J and P Geldhof. In-depth Analysis of the Adult Stage Excretome/Secretome of the Parasitic Nematode Cooperia oncophora, J Proteome Res. 2013 Jul 29. PMID:23895670.

88. Davis C, Kota K, Baldhandapani V, Gong W, Abubucker S, Becker E, Martin J, Wylie KM, Khetani R, Hudson ME, Weinstock GM, Mitreva M. mBLAST: Keeping up with the sequencing explosion for (meta)genome analysis. J Data Mining Genomics Proteomics. 2015 Aug;4(3). pii: 135. Epub 2013 Jul 31. PubMed PMID: 26500804; PubMed Central PMCID: PMC4612494.

89. Taylor CM, Wang Q, Rosa BA, Huang SC, Powell K, Schedl T, Pearce EJ, Abubucker S, Mitreva M. Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways. PLoS Pathog. 2013;9(8):e1003505. PMID: 23935495 PMCID: PMC3731235.

90. Turabelidze G, Lawrence SJ, Gao H, Sodergren E, Weinstock GM, Abubucker S, Wylie T, Mitreva M, Shaikh N, Gautom R, Tarr PI. Precise Dissection of an Escherichia coli O157:H7 Outbreak by Single Nucleotide Polymorphism Analysis. J Clin Microbiol. 2013 Dec;51(12):3950-4. Epub 2013 Sep 18. PubMed PMID: 24048526.

91. Rosa AB, Jasmer DP and Mitreva M. Genome-wide tissue-specific gene expression, co-expression and regulation of co-expressed genes in adult nematode Ascaris suum, PLoS Neglected Tropical Diseases, PLoS Negl Trop Dis. 2014 Feb 6;8(2):e2678. PubMed PMID: 24516681; PubMedCentral PMCID: PMC3916258.

92. Mangiola S, Young ND, Sternberg PW, Strube C, Korhonen PK, Hofmann A, Mitreva M, Scheerlinck J-P, Jex AR, Gasser RB - Comparative analyses of the transcriptomes of Dictyocaulus filaria and D. viviparus adults elucidate key molecules involved in parasite-host interactions. International Journal for Parasitology, 2014 Jan 31. PubMed PMID: 24487001.

93. Tang YT, Gao X, Rosa BA, Abubucker S, Hallsworth-Pepin K, Martin J, Tyagi R, Heizer E, Zhang X, Bhonagiri-Palsikar V, Minx P, Warren WC, Wang Q, Zhan B, Hotez PJ, Sternberg PW, Dougall A, Gaze ST, Mulvenna J, Sotillo J, Ranganathan S, Rabelo EM, Wilson RK, Felgner PL, Bethony J, Hawdon JM, Gasser RB, Loukas A, Mitreva M. Genome of the human hookworm Necator americanus. Nat Genet. 2014 Mar;46(3):261-9. PubMed PMID: 24441737;PubMed Central PMCID: PMC3978129.

94. Abubucker S, McNulty SN, Rosa BA, Mitreva M. Identification and characterization of alternative splicing in parasitic nematode transcriptomes. Parasit Vectors. 2014 Apr 1;7:151. doi: 10.1186/1756-3305-7-151. PubMed PMID:24690220; PubMed Central PMCID: PMC3997825.

95. Carl MA, Ndao IM, Springman AC, Manning SD, Johnson JR, Johnston BD, Burnham CA, Weinstock ES, Weinstock GM, Wylie TN, Mitreva M, Abubucker S, Zhou Y, Stevens HJ,


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Hall-Moore C, Julian S, Shaikh N, Warner BB, Tarr PI. Sepsis from the gut: the enteric habitat of bacteria that cause late-onset neonatal bloodstream infections. Clin Infect Dis. 2014 May;58(9):1211-8. PubMed PMID: 24647013.

96. Cantacessi C, Giacomin P, Croese J, Zakrzewski M, Sotillo J, McCann L, Nolan MJ, Mitreva M, Krause L, Loukas A. Impact of experimental hookworm infection on the human gut microbiota. J Infect Dis. 2014 May 3. PubMed PMID: 24795483.

97. Kraal L, Abubucker S, Kota K, Fischbach MA, Mitreva M. The prevalence of species and strains in the human microbiome: a resource for experimental efforts. PLoS One. 2014 May 14;9(5):e97279. PubMed PMID: 24827833; PubMed Central PMCID: PMC4020798.

98. Zhou Y, Gao H, Mihindukulasuriya KA, La Rosa PS, Wylie KM, Martin JC, Kota K, Shannon WD, Mitreva M, Sodergren E and Weinstock GM. Exploration of Bacterial Community Classes in Major Human Habitats, Genome Biol., 2014 May 7;15(5):R66. PubMed PMID: 24887286.

99. Rutter WB, Hewezi T, Abubucker S, Maier TR, Huang G, Mitreva M, Hussey RS, Baum TJ. Mining novel effector proteins from the esophageal gland cells of Meloidogyne incognita, Molecular Plant-Microbe Interactions, 2014 May 29. PubMed PMID: 24875667.

100. Sotillo J, Sanchez-Flores A, Cantacessi C, Harcus Y, Pickering D, Bouchery T, Camberis M, Tang SC, Giacomin P, Mulvenna J, Mitreva M, Berriman M, LeGros G, Maizels RM, Loukas A. Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensis. Mol Cell Proteomics. 2014 Oct;13(10):2736-51. PubMed PMID: 24994561; PubMed Central PMCID: PMC4188999.

101. Ondrovics M, Silbermayr K, Mitreva M, Young ND, Gasser RB, Joachim A. Proteomics elucidates key molecules involved in exsheathment in vitro in Oesophagostomum dentatum. Int J Parasitol. 2014 Oct 1;44(11):759-64. PubMed PMID: 25036992; PubMed Central PMCID: PMC4249666.

102. Donia MS, Cimermancic P, Schulze CJ, Wieland Brown LC, Martin J, Mitreva M, Clardy J, Linington RG, Fischbach MA. A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. Cell. 2014 Sep 11;158(6):1402-14. PubMed PMID: 25215495; PubMed Central PMCID: PMC4164201.

103. McNulty SN, Fischer PU, Townsend RR, Curtis KC, Weil GJ, Mitreva M. Systems biology studies of adult paragonimus lung flukes facilitate the identification of immunodominant parasite antigens. PLoS Negl Trop Dis. 2014 Oct 16;8(10):e3242. PubMed PMID: 25329661;PubMed Central PMCID: PMC4199545.

104. Martin J, Rosa BA, Ozersky P, Hallsworth-Pepin K, Zhang X, Bhonagiri-Palsikar V, Tyagi R, Wang Q, Choi YJ, Gao X, McNulty SN, Brindley PJ, Mitreva M. Helminth.net: expansions to Nematode.net and an introduction to Trematode.net. Nucleic Acids Res. 2015 Jan 28;43(Database issue):D698-706. PubMed PMID: 25392426.

105. Jasmer DP, Rosa BA, Mitreva M. Peptidases Compartmentalized to the Ascaris suum Intestinal Lumen and Apical Intestinal Membrane. PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3375. PubMed PMID: 25569475; PubMed Central PMCID: PMC4287503.

106. Rosa BA, Townsend R, Jasmer DP, Mitreva M. Functional and phylogenetic characterization of proteins detected in various nematode intestinal compartments. Mol Cell Proteomics. 2015 Jan 21. pii: mcp.M114.046227. PubMed PMID: 25609831.

107. Shi B, Chang M, Martin J, Mitreva M, Lux R, Klokkevold P, Sodergren E, Weinstock GM, Haake SK, Li H. Dynamic changes in the subgingival microbiome and their potential for diagnosis and prognosis of periodontitis. MBio. 2015 Feb 17;6(1):e01926-14. PubMed PMID: 25691586; PubMed Central PMCID: PMC4337560.


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108. Tyagi R, Rosa BA, Lewis WG, Mitreva M. Pan-phylum Comparison of Nematode Metabolic Potential. PLoS Negl Trop Dis. 2015 May 22;9(5):e0003788. PubMed PMID: 26000881; PubMed Central PMCID: PMC4441503.

109. Tyagi R, Joachim A, Ruttkowski B, Rosa BA, Martin JC, Hallsworth-Pepin K, Zhang X, Ozersky P, Wilson RK, Ranganathan S, Sternberg PW, Gasser RB, Mitreva M. Cracking the nodule worm code advances knowledge of parasite biology and biotechnology to tackle major diseases of livestock. Biotechnol Adv. 2015 Nov 1;33(6 Pt 1):980-91. PubMed PMID: 26026709.

110. Nobel YR, Cox LM, Kirigin FF, Bokulich NA, Yamanishi S, Teitler I, Chung J, Sohn J, Barber CM, Goldfarb DS, Raju K, Abubucker S, Zhou Y, Ruiz VE, Li H, Mitreva M, Alekseyenko AV, Weinstock GM, Sodergren E, Blaser MJ. Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment. Nat Commun. 2015 Jun 30;6:7486. PubMed PMID: 26123276; PubMed Central PMCID: PMC4491183.

111. Ordiz MI, May TD, Mihindukulasuriya K, Martin J, Crowley J, Tarr PI, Ryan K, Mortimer E, Gopalsamy G, Maleta K, Mitreva M, Young G, Manary MJ. The effect of dietary resistant starch type 2 on the microbiota and markers of gut inflammation in rural Malawi children. Microbiome. 2015 Sep 3;3:37. PubMed PMID: 26334878; PubMed Central PMCID: PMC4558878.

112. Giacomin P, Zakrzewski M, Croese J, Su X, Sotillo J, McCann L, Navarro S, Mitreva M, Krause L, Loukas A, Cantacessi C. Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects. Sci Rep. 2015 Sep 18;5:13797. PubMed PMID: 26381211; PubMed Central PMCID: PMC4585380.

113. Wang Q, Rosa BA, Nare B, Powell K, Valente S, Rotili D, Mai A, Marshall GR, Mitreva M. Targeting Lysine Deacetylases (KDACs) in Parasites. PLoS Negl Trop Dis. 2015 Sep 24;9(9):e0004026. PubMed PMID: 26402733; PubMed Central PMCID: PMC4581690.

114. Muñoz JF, Gauthier GM, Desjardins CA, Gallo JE, Holder J, Sullivan TD, Marty AJ, Carmen JC, Chen Z, Ding L, Gujja S, Magrini V, Misas E, Mitreva M, Priest M, Saif S, Whiston EA, Young S, Zeng Q, Goldman WE, Mardis ER, Taylor JW, McEwen JG, Clay OK, Klein BS, Cuomo CA. The Dynamic Genome and Transcriptome of the Human Fungal Pathogen Blastomyces and Close Relative Emmonsia. PLoS Genet. 2015 Oct 6;11(10):e1005493. PubMed PMID: 26439490; PubMed Central PMCID: PMC4595289.

115. McNulty SN, Rosa BA, Fischer PU, Rumsey JM, Erdmann-Gilmore P, Curtis KC, Specht S, Townsend RR, Weil GJ, Mitreva M. An Integrated Multiomics Approach to Identify Candidate Antigens for Serodiagnosis of Human Onchocerciasis. Mol Cell Proteomics. 2015 Dec;14(12):3224-33. PubMed PMID: 26472727; PubMed Central PMCID: PMC4762623.

116. Wang Q, Rosa BA, Jasmer DP, Mitreva M. Pan-Nematoda Transcriptomic Elucidation of Essential Intestinal Functions and Therapeutic Targets With Broad Potential. EBioMedicine. 2015 Jul 29;2(9):1079-89. PubMed PMID: 26501106; PubMed Central PMCID: PMC4587998.

117. Monin L, Griffiths KL, Lam WY, Gopal R, Kang DD, Ahmed M, Rajamanickam A, Cruz-Lagunas A, Zúñiga J, Babu S, Kolls JK, Mitreva M, Rosa BA, Ramos-Payan R, Morrison TE, Murray PJ, Rangel-Moreno J, Pearce EJ, Khader SA. Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis. J Clin Invest. 2015 Dec;125(12):4699-713. PubMed PMID: 26571397; PubMed Central PMCID: PMC4665786.

118. Wang Q, Heizer E, Rosa BA, Wildman SA, Janetka JW, Mitreva M. Characterization of parasite-specific indels and their proposed relevance for selective anthelminthic drug


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targeting. Infect Genet Evol. 2016 Apr;39:201-11. PubMed PMID: 26829384; PubMed Central PMCID: PMC4789095.

119. McNulty SN, Strübe C, Rosa BA, Martin JC, Tyagi R, Choi YJ, Wang Q, Hallsworth Pepin K, Zhang X, Ozersky P, Wilson RK, Sternberg PW, Gasser RB, Mitreva M. Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention. Sci Rep. 2016 Feb 9;6:20316. PubMed PMID: 26856411; PubMed Central PMCID: PMC4746573.

120. Gao X, Tyagi R, Magrini V, Ly A, Jasmer DP, Mitreva M. Compartmentalization of functions and predicted miRNA regulation among contiguous regions of the Nematode Intestine. RNA Biol. 2016 Mar 22:0. PubMed PMID:27002534.

121. Zhang J, Gao X, Martin J, Rosa B, Chen Z, Mitreva M, Henrich T, Kuritzkes D, Ratner L. Evolution of coreceptor utilization to escape CCR5 antagonist therapy. Virology. 2016 Jul;494:198-214. PubMed PMID: 27128349; PubMed Central PMCID: PMC4913893.

122. Zarlenga D, Wang Z, Mitreva M. Trichinella spiralis: Adaptation and parasitism. Vet Parasitol. 2016 Jul 2. pii: S0304-4017(16)30262-X. PubMed PMID: 27425574.

123. Hang L, Blum AM, Kumar S, Urban JF Jr, Mitreva M, Geary TG, Jardim A, Stevenson MM, Lowell CA, Weinstock JV. Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis. J Immunol. 2016 Aug 24. PubMed PMID: 27559049.

124. Li BW, McNulty SN, Rosa BA, Tyagi R, Zeng QR, Gu KZ, Weil GJ, Mitreva M. Conservation and diversification of the transcriptomes of adult Paragonimus westermani and P. skrjabini. Parasit Vectors. 2016 Sep 13;9:497. PubMed PMID: 27619014.

125. Wei J, Damania A, Gao X, Liu Z, Mejia R, Mitreva M, Strych U, Bottazzi ME, Hotez PJ, Zhan B. The hookworm Ancylostoma ceylanicum intestinal transcriptome provides a platform for selecting drug and vaccine candidates. Parasit Vectors. 2016 Sep 27;9(1):518. PubMed PMID: 27677574; PubMed Central PMCID: PMC5039805.

126. Weimer CM, Deitzler GE, Robinson LS, Park S, Hallsworth-Pepin K, Wollam A, Mitreva M, Lewis WG, Lewis AL. Genome Sequences of 12 Bacterial Isolates Obtained from the Urine of Pregnant Women. Genome Announc. 2016 Sep 29;4(5). PubMed PMID: 27688327; PubMed Central PMCID: PMC5043545.

127. Lewis AL, Deitzler GE, Ruiz MJ, Weimer C, Park S, Robinson LS, Hallsworth-Pepin K, Wollam A, Mitreva M, Lewis WG. Genome Sequences of 11 Human Vaginal Actinobacteria Strains. Genome Announc. 2016 Sep 29;4(5). PubMed PMID: 27688328; PubMed Central PMCID:PMC5043546.

128. Deitzler GE, Ruiz MJ, Weimer C, Park S, Robinson L, Hallsworth-Pepin K, Wollam A, Mitreva M, Lewis AL, Lewis WG. Genome Sequences of 14 Firmicutes Strains Isolated from the Human Vagina. Genome Announc. 2016 Sep 29;4(5). PubMed PMID: 27688329; PubMed Central PMCID:PMC5043547.

129. Deitzler GE, Ruiz MJ, Lu W, Weimer C, Park S, Robinson LS, Hallsworth-Pepin K, Wollam A, Mitreva M, Lewis WG, Lewis AL. Genome Sequences of Nine Gram-Negative Vaginal Bacterial Isolates. Genome Announc. 2016 Sep 29;4(5). PubMed PMID: 27688330; PubMed Central PMCID:PMC5043548.

130. Giacomin P, Zakrzewski M, Jenkins T, Su X, Al-Hallaf R, Croese J, de Vries S, Grant A, Mitreva M, Loukas A, Krause L, and Cantacessi C. Changes in duodenal tissue-associated microbiota following hookworm infection and consecutive gluten challenges in humans with coeliac disease, Sci Rep. 2016 Nov 9;6:36797. PubMed PMID: 27827438; PubMed Central PMCID: PMC5101533.


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131. Choi YJ, Tyagi R, McNulty SN, Rosa BA, Ozersky P, Martin J, Hallsworth-Pepin K , Unnasch TR, Norice CT, Nutman TB, Weil GJ, Fischer PU, and Mitreva M. Genomic diversity in Onchocerca volvulus and its Wolbachia endosymbiont, Nature Microbiology, 2016 Nov 21;2:16207. doi: 10.1038/nmicrobiol.2016.207. PubMed PMID: 27869792.

132. Torbati ME, Mitreva M, Gopalakrishnan V. Application of Taxonomic Modeling to Microbiota Data Mining for Detection of Helminth Infection in Global Populations. Data (Basel). 2016 Dec;1(3). pii: 19. PubMed PMID: 28239609; PubMed Central PMCID: PMC5325162.

133. McNulty SN, Tort JF, Rinaldi G, Fischer K, Rosa BA, Smircich P, Fontenla S, Choi YJ, Tyagi R, Hallsworth-Pepin K, Mann VH, Kammili L, Latham PS, Dell'Oca N, Dominguez F, Carmona C, Fischer PU, Brindley PJ, Mitreva M. Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers. PLoS Genet. 2017 Jan 6;13(1):e1006537. PubMed PMID: 28060841; PubMed Central PMCID: PMC5257007.

134. Rosa BA, Hallsworth-Pepin K, Martin J, Wollam A, Mitreva M. Genome Sequence of Christensenella minuta DSM 22607T. Genome Announc. 2017 Jan 12;5(2). PubMed PMID: 28082495; PubMed Central PMCID: PMC5256218.

135. Rosa BA, McNulty SN, Mitreva M, Jasmer DP. Direct experimental manipulation of intestinal cells in Ascaris suum, with minor influences on the global transcriptome. Int J Parasitol. 2017 Apr;47(5):271-279. PubMed PMID: 28223178; PubMed Central PMCID: PMC5423655.

136. Tomassini Barbarossa I, Ozdener MH, Melania, Love-Gregory L, Mitreva M, Abumrad NA, Pepino MY. Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people. Behav Brain Res. 2017 Jun 30;329:200-204. PubMed PMID:28487220.

137. Choi YJ, Bisset SA, Doyle SR, Hallsworth-Pepin K, Martin J, Grant WN and Mitreva M. Genomic Introgression Mapping 1 of Field-Derived Multiple-Anthelmintic Resistance in Teladorsagia circumcincta, PLoS Genetics. Accepted, June 16, 2017.

138. Norice-Tra CT, Ribeiro J, Bennuru S, Fay MP, Tyagi R, Mitreva M, Nutman TB; Insights into Onchocerca volvulus population biology through multilocus immunophenotyping. J Infect Dis. 2017 Sep 15;216(6):736-743. PubMed PMID: 28934436.

139. Dobbs KR, Embury P, Vulule J, Odada PS, Rosa BA, Mitreva M, Kazura JW, Dent AE. Monocyte dysregulation and systemic inflammation during pediatric falciparum malaria. JCI Insight. 2017 Sep 21;2(18). pii: 95352. doi:10.1172/jci.insight.95352. PubMed PMID: 28931756; PubMed Central PMCID: PMC5621919.

140. Rosa BA, Supali T, Gankpala L, Djuardi Y, Sartono E, Zhou Y, Fischer K, Martin J, Tyagi R, Bolay FK, Fischer PU, Yazdanbakhsh M, Mitreva M. Differential human gut microbiome assemblages during soil-transmitted helminth infections in Indonesia and Liberia. Microbiome. 2018 Feb 28;6(1):33. doi:10.1186/s40168-018-0416-5. PubMed PMID: 29486796.

141. Magrini V, Gao X, Rosa BA, McGrath S, Zhang X, Hallsworth-Pepin K, Martin J, Hawdon J, Wilson RK, Mitreva M. Improving eukaryotic genome annotation using single molecule mRNA sequencing. BMC Genomics. 2018 Mar 1;19(1):172. doi:10.1186/s12864-018-4555-7. PubMed PMID: 29495964; PubMed Central PMCID:PMC5833154.

142. Tyagi R, Maddirala AR, Elfawal M, Fischer C, Bulman CA, Rosa BA, Gao X, Chugani R, Zhou M, Helander J, Brindley PJ, Tseng CC, Greig IR, Sakanari J, Wildman SA, Aroian R, Janetka JW, Mitreva M. Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a


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New Class of Anthelmintics. ACS Infect Dis. 2018 May 14. doi: 10.1021/acsinfecdis.8b00090. PubMed PMID:29718656.

143. Martin I, Djuardi Y, Sartono E, Rosa BA, Supali T, Mitreva M, Houwing-Duistermaat JJ, Yazdanbakhsh M. Dynamic changes in human-gut microbiome in relation to a placebo-controlled anthelminthic trial in Indonesia. PLoS Negl Trop Dis. 2018 Aug 9;12(8):e0006620. doi: 10.1371/journal.pntd.0006620. eCollection 2018 Aug. PubMed PMID: 30091979.

144. Dunlap MD, Howard N, Das S, Scott N, Ahmed M, Prince O, Rangel-Moreno J, Rosa BA, Martin J, Kaushal D, Kaplan G, Mitreva M, Kim KW, Randolph GJ, Khader SA. A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis. Mucosal Immunol. 2018 Aug 16. doi:10.1038/s41385-018-0071-y. [Epub ahead of print] PubMed PMID: 30115997.

145. Howard NC, Marin ND, Ahmed M, Rosa BA, Martin J, Bambouskova M, Sergushichev A, Loginicheva E, Kurepina N, Rangel-Moreno J, Chen L, Kreiswirth BN, Klein RS, Balada-Llasat JM, Torrelles JB, Amarasinghe GK, Mitreva M, Artyomov MN, Hsu FF, Mathema B, Khader SA. Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nat Microbiol. 2018 Oct;3(10):1099-1108. doi: 10.1038/s41564-018-0245-0. Epub 2018 Sep 17. Erratum in: Nat Microbiol. 2018 Nov;3(11):1327. PubMed PMID:30224802; PubMed Central PMCID: PMC6158078.

146. Leroux LP, Nasr M, Valanparambil R, Tam M, Rosa BA, Siciliani E, Hill DE, Zarlenga DS, Jaramillo M, Weinstock JV, Geary TG, Stevenson MM, Urban JF Jr, Mitreva M, Jardim A. Analysis of the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties. Sci Rep. 2018 Oct 29;8(1):15921. doi: 10.1038/s41598-018-34174-4. PubMed PMID: 30374177; PubMed Central PMCID: PMC6206011.

147. Zarlenga DS, Mitreva M, Thompson P, Tyagi R, Tuo W, Hoberg EP. A tale of three kingdoms: members of the Phylum Nematoda independently acquired the detoxifying enzyme cyanase through horizontal gene transfer from plants and bacteria. Parasitology. 2018 Oct 10:1-8. doi: 10.1017/S0031182018001701. [Epub ahead of print] PubMed PMID: 30301483.

148. International Helminth Genomes Consortium*. Comparative genomics of the major parasitic worms. Nature Genetics, Nov 5th, 2018. doi: 10.1038/s41588-018-0262-1.. * Co-senior authors: Berriman M, and Mitreva M.

149. McCoy WH 4th, Otchere E, Rosa BA, Martin J, Mann CM, Mitreva M. Skin Ecology During Sebaceous Drought-How Skin Microbes Respond to Isotretinoin. J Invest Dermatol. 2018 Oct 24. PubMed PMID: 30579608.

Invited publications (e.g. reviews, book chapters, etc): 150. Parkinson J, Mitreva M, Hall N, Blaxter M, McCarter JP, 400000 nematode ESTs on the

Net. Trends Parasitol. 2003: 19(7):283-6; PubMed PMID: 12855373. 151. McCarter JP, Mitreva M, Clifton SW, Bird DM, Waterston RH, Nematode gene

sequences: update for december 2003. J Nematol. 2003: 35(4):465-9. PMID: 19262781; PubMed Central PMCID: PMC2620685.

152. Mitreva M, Appleton J, McCarter JP, Jasmer DP, Expressed sequence tags from life cycle stages of Trichinella spiralis: application to biology and parasite control. Vet Parasitol. 2005: 132(1-2): 13-7; PubMed PMID: 15993542.


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153. Bird DM, Blaxter ML, McCarter JP, Mitreva M, Sternberg PW, Thomas WK, A white paper on nematode comparative genomics. J Nematol. 2005: 37(4): 408-16; PubMed PMID: 19262884; PubMed Central PMCID: PMC2620993.

154. McCarter JP, Bird DM, Mitreva M, Nematode gene sequences: update for December 2005. J Nematol. 2005: 37(4): 417-21; PubMed PMID: 19262885; PubMed Central PMCID: PMC2620984.

155. Mitreva M, Blaxter ML, Bird DM, McCarter JP, Comparative genomics of nematodes. Trends Genet. 2005: 21(10): 573-81; PubMed PMID: 16099532.

156. Mitreva M, Jasmer DP, Biology and genome of Trichinella spiralis. WormBook 2006:1-21; PubMed PMID: 17560034.

157. Mitreva M, Zarlenga DS, McCarter JP, Jasmer DP, Parasitic nematodes – from genomes to control. Vet Parasitol. 2007: 148(1): 31-42; PubMed PMID: 17560034.

158. Mitreva M, Jasmer DP, Advances in the sequencing of the genome of the adenophorean nematode Trichinella spiralis. Parasitology 2008: 135(8): 869-80; PubMed PMID: 18598573.

159. Mitreva M, Smant G, Helder J, Role of horizontal gene transfer in the evolution of plant parasitism among nematodes. Methods Mol Biol. 2009: 532: 517-35; PubMed PMID: 19271205.

160. Clifton SW, Mitreva M, Strategies for undertaking expressed sequence tag (EST) projects. Methods Mol Biol. 2009: 533: 13-32; PubMed PMID: 19277564.

161. Mitreva M, Mardis ER, Large-scale sequencing and analytical processing of ESTs. Methods Mol Biol. 2009: 533: 153-87; PubMed PMID: 19277558.

162. Brindley P, Mitreva M, Ghedin E, Lustigman S, Helminth Genomics: The implications for human health. PLoS Neglected Tropical Diseases 2009: 3(10): e538; PubMed PMID: 19855829; PubMed Central PMCID: PMC2757907.

163. Mitreva M, Jasmer DP. Trichinella spiralis: Genomic Application to Control a Zoonotic Nematode. Infect Disord Drug Targets, 2010, 10(5):376-84. PubMed Central PMID: 20701572.

164. Jacob J and Mitreva M, Transcriptomes of Plant parasitic nematodes, in Exploiting Genomics to Understand Plant-Nematode Interactions. Editors: Jones J, Gheysen G. and Fenoll C. Publisher, Springer, 2011.

165. Mitreva, M. The genome of a blood fluke associated with human cancer. Nature Genetics 2012, Jan 27;44(2):116-8. doi: 10.1038/ng.1082.

166. McNulty SN, Mitreva M, Weil GJ and PU Fischer. Inter and Intra-specific diversity of parasites that cause lymphatic filariasis, Infect Genet Evol. 2012 Nov 29;14C:137-146. PubMed PMID: 23201850.

167. Blair D, Nawa Y, Mitreva M, Doanh PN. Gene diversity and genetic variation in lung flukes (genus Paragonimus). Trans R Soc Trop Med Hyg. 2016 Jan;110(1):6-12. doi: 10.1093/trstmh/trv101. Review. PubMed PMID: 26740357.

168. Mitreva M., The microbiome in infectious diseases, in Infectious Diseases, 4th edition (section 1, chapter 8), Section editor, Robert T. Schooley; Lead Editor, William G. Powderly, Editors: Cohen J, Powderly WG and Opal SM, 2016.

169. Martin J, Tyagi R, Rosa BA, Mitreva M. A Multi-Omics Database for Parasitic Nematodes and Trematodes. Methods Mol Biol. 2018;1757:371-397. doi:10.1007/978-1-4939-7737-6_13. PubMed PMID: 29761465.

170. International Molecular Helminthology Annotation Network (IMHAN); IMHAN consortium authors include, Palevich N, Britton C, Kamenetzky L, Mitreva M, de Moraes Mourão M, Bennuru S, Quack T, Scholte LLS, Tyagi R, Slatko BE. Tackling Hypotheticals in Helminth


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Genomes. Trends Parasitol. 2018 Mar;34(3):179-183. doi:10.1016/j.pt.2017.11.007. Epub 2017 Dec 14. PubMed PMID: 29249363.

171. Tyagi R, Rosa BA and Mitreva M. Omics-driven knowledge based discovery of anthelmintic targets and drugs. In book: In Silico Drug Design Methods for Drug Repurposing. Editor, Kunal Roy, 2018, in press.

MEDIA COVERAGE (press articles, movies, videotapes, etc): 2011 Trichinosis parasite gets DNA decoded (February 20, 2011). Retrieved from https://source.wustl.edu/2011/02/trichinosis-parasite-gets-dna-decoded/ Trichinosis parasite gets DNA decoded [with video file] (February 21, 2011) Retrieved from https://phys.org/news/2011-02-trichinosis-parasite-dna-decoded.html https://www.sciencedaily.com/releases/2011/02/110220142819.htm https://www.eurekalert.org/pub_releases/2011-02/wuso-tpg021811.php http://esciencenews.com/articles/2011/02/20/trichinosis.parasite.gets.dna.decoded Everything you wanted to know about a parasitic worm (February 22, 2011) Retrieved from http://archive.jsonline.com/blogs/news/116668874.html

Researchers Sequence Genome of Trichinosis Parasite (February 21, 2011) Retrieved from https://www.genomeweb.com/sequencing/researchers-sequence-genome-trichinosis-parasite#.WwIqIS-ZNp8 2012 Census of microbes in healthy humans reported (WUSM The Source, Medicine & Health; June 13, 2012) Retrieved from https://source.wustl.edu/2012/06/census-of-microbes-in-healthy-humans-reported/ A new genetic fingerprint lives in your belly (WUSM The Source, Medicine & Health; December 5th, 2012). Retrieved from https://source.wustl.edu/2012/12/a-new-genetic-fingerprint-lives-in-your-belly/ 2013 Funding aids new test for ‘river blindness’ (WUSM The Source, Medicine & Health; October 2, 2013). Retrieved from https://source.wustl.edu/2013/10/funding-aids-new-test-for-river-blindness/ 2014 Decoding the hookworm genome [with audio; January 28, 2014) in TheGolabalDispatch. Retrieved from https://www.youtube.com/watch?v=aqt7HU_yYKs Decoded: DNA of blood-sucking worm that infects world’s poor (WUSM The Source, Medicine & Health; January 19, 2014) Retrieved from https://source.wustl.edu/2014/01/decoded-dna-of-bloodsucking-worm-that-infects-worlds-poor/ Hookworm gets the genome treatment (ABC Science, January 20, 2014). Retrieved from http://www.abc.net.au/science/articles/2014/01/20/3928649.htm


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Decoded hookworm DNA helps highlight drug targets (BioNews; January 20, 2014). Retrieved from https://www.bionews.org.uk/page_94456

2015 A global network (WUSM The Source, Medicine & Health; September 7th, 2015). Retrieved from https://source.wustl.edu/2015/09/a-global-network/ 2016 Study sheds light on parasite that causes river blindness (WUSM The Source, Medicine & Health; November 22, 2016). Retrieved from https://medicine.wustl.edu/news/study-sheds-light-parasite-causes-river-blindness/

Exploring the genome of the river blindness parasite (NIH Research Matters; December 6, 2016) Retrieved from https://www.nih.gov/news-events/nih-research-matters/exploring-genome-river-blindness-parasite

2018 Gut microbes influence severity of intestinal parasitic infections (WUSM The Source, Medicine & Health; March 8th, 2018) Retrieved from https://medicine.wustl.edu/news/gut-microbes-influence-severity-intestinal-parasitic-infections/

Could You Fight Off Worms? Depends On Your Gut Microbes (NPR, Infectious Diseases; April 7th, 2018). Retrieved from https://www.npr.org/sections/goatsandsoda/2018/04/07/598093165/could-you-fight-off-worms-depends-on-your-gut-microbes

Quantum leap in parasite worm treatment research with largest ever helminth genome study (McDonnell Genome Institute, November 5th, 2018). Retrieved from https://www.genome.wustl.edu/quantum-leap-in-parasite-worm-treatment/

Largest parasitic worm genetic study hatches novel treatment possibilities (Welcome Sanger Institute News article, November 5th, 2018). Retrieved from https://www.sanger.ac.uk/news/view/largest-parasitic-worm-genetic-study-hatches-novel-treatment-possibilities. Gene study reveals secrets of parasitic worms, possible treatments (Reuters, November 5th, 2018). Retrieved from https://uk.reuters.com/article/us-health-worms/gene-study-reveals-secrets-of-parasitic-worms-possible-treatments-idUKKCN1NA21V Researchers analyse genomes of 81 parasitic worm species (The Scientist, November 5th, 2018). Retrieved from https://www.the-scientist.com/news-opinion/researchers-analyze-genomes-of-81-parasitic-worm-species--65040

Largest parasitic worm genetic study hatches novel treatment possibilities (Science Daily, November 5th, 2018). Retrieved from https://www.sciencedaily.com/releases/2018/11/181105122530.htm


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Gene study reveals secrets of parasitic worms, possible treatments (Daily Mail, November 5th, 2018). Retried from https://www.dailymail.co.uk/wires/reuters/article-6355137/Gene-study-reveals-secrets-parasitic-worms-possible-treatments.html

Parasitic worm study predicts potential drug targets and drugs (Drug Target Review, Novemebr 6th, 2018). Retrieved from https://www.drugtargetreview.com/news/36514/worm-targets-drugs/

Study of genes uncoveres secrets of parasitic worms and new ways to treat them (Firstpost, November 6th, 2018). Retrieved from https://www.firstpost.com/tech/science/study-of-genes-uncovers-secrets-of-parasitic-worms-and-new-ways-to-treat-infections-5510891.html

Gene study reveals secrets of parasitic worms (Gulf Times, November 6th, 2018) Retrieved from https://www.gulf-times.com/story/612073/Gene-study-reveals-secrets-of-parasitic-worms

Gene study reveals secrets of parasitic worms, possible treatments (Business Insider, November 6th, 2018). Retrieved from http://uk.businessinsider.com/r-gene-study-reveals-secrets-of-parasitic-worms-possible-treatments-2018-11

Large genomics effort yields antiparasite targets (Chemical and Engineering News, November 6th, 2018). Retrieved from https://cen.acs.org/biological-chemistry/genomics/Large-genomics-effort-yields-antiparasite/96/i45

Medication for severe acne alters skin microbiome (WUSM The Source, Medicine & Health; December 21th, 2018). Retrieved from https://medicine.wustl.edu/news/medication-for-severe-acne-alters-skin-microbiome/

New Acne Treatment Might Spring From Old One (HealthDay, December 21, 2018). Retrieved from https://consumer.healthday.com/kids-health-information-23/acne-news-3/new-acne-treatment-might-spring-from-old-one-740968.html

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