29 Curriculum Vitae Martin Morad Home Address: 3 Chisolm St., #302 Charleston, SC 29401 Office Mailing Address: Department of Pharmacology (& Department of Cell Biology and Anatomy) Medical University of South Carolina BSB 358 173 Ashley Avenue, MSC 505 Charleston, SC 29425 Office: Bioengineering Building, BEB 306 Citizenship: U.S.A. Education: B.A., Lake Forest College Ph.D., Physiology, State University of New York, New York City Postgraduate Training and Fellowship Appointments: 1965-67 Post-doctoral Fellow (Prof. W. Trautwein) Department of Physiology, Heidelberg University, West Germany 1967-69 Post-doctoral Fellow (Prof. Brady and Langer) Department of Physiology and Heart Lab, UCLA Faculty Appointments: 2008- Blue Cross Blue Shield of South Carolina Endowed Chair in Cardiovascular Health University of South Carolina, Medical University of South Carolina, Clemson University 2008- Adjunct Professor of Pharmacology and Medicine, Georgetown University Medical Center 1993-2008 Professor of Pharmacology and Medicine, Georgetown University Medical Center 1993 Professor and Chairman, Department of Physiology and Biophysics, Georgetown University Medical Center 1980-1993 Professor of Physiology and Medicine, University of Pennsylvania, School of Medicine 1973-80 Associate Professor Physiology, University of Pennsylvania, School of Medicine
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Curriculum Vitae Martin Morad
Home Address: 3 Chisolm St., #302 Charleston, SC 29401 Office Mailing Address: Department of Pharmacology (& Department of Cell Biology and Anatomy) Medical University of South Carolina BSB 358 173 Ashley Avenue, MSC 505 Charleston, SC 29425 Office: Bioengineering Building, BEB 306 Citizenship: U.S.A. Education: B.A., Lake Forest College Ph.D., Physiology, State University of New York, New York City Postgraduate Training and Fellowship Appointments: 1965-67 Post-doctoral Fellow (Prof. W. Trautwein) Department of Physiology, Heidelberg University, West Germany 1967-69 Post-doctoral Fellow (Prof. Brady and Langer) Department of Physiology and Heart Lab, UCLA Faculty Appointments: 2008- Blue Cross Blue Shield of South Carolina Endowed Chair in Cardiovascular Health University of South Carolina, Medical University of South Carolina, Clemson University
2008- Adjunct Professor of Pharmacology and Medicine, Georgetown University Medical Center
1993-2008 Professor of Pharmacology and Medicine, Georgetown University Medical Center
1993 Professor and Chairman, Department of Physiology and Biophysics, Georgetown University Medical Center
1980-1993 Professor of Physiology and Medicine, University of Pennsylvania, School of Medicine
1973-80 Associate Professor Physiology, University of Pennsylvania, School of Medicine
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1970-73 Assistant Professor of Physiology, University of Pennsylvania, School of Medicine
Awards, Honors, and Memberships in Honorary Societies: 2017 Recipient of “The Jan Slezak Award for Excellence in Cardiovascular Sciences”
in Hungary.
2016 Member of Scientific Executive Council of IACS until 2020. 2014, Key note speaker at the 5th Charleston light microscopy workshop at MUSC,
2014 Received “The Distinguished Faculty Award”, of IACS, in India. 2014 Received “The Makoto Nagano Award for Distinguished achievements in Cardiovascular Education”, in Canada, 2014 Elected as a Fellow of International Academy of Cardiovascular Sciences (IACS) 2014 Keynote speaker at 101st India Science Congress, Kashmir India 2013 Awarded the Georgetown University Distinguished Service Medal. 2001 Founding fellow of International Society for Heart Research
1997 Phi Beta Kappa of Lake Forest College
1996-1999 President, Cardiac Muscle Society
1993-95 Secretary, Treasurer, Cardiac Muscle Society
1990-95 Trustee, Mount Desert Island Biological Laboratory, Salisbury Cove, ME
1990-95 Member, Advisory Board Center for Excellence in Cardiovascular Research, Graduate Health System
1988 President of Bayer Centenary Symposium on Ca2+ Channel Structure and Function
1988 Selected as Benjamin Meaker Visiting Professorship, University of Bristol, U.K.
1986- Trustee, Caribbean Neuroscience Foundation
1986-87 Alexander von Humboldt Senior Scientist Prize for work on electrical regulation of cardiac contractility
1986 President, Gordon Research Conference on Cardiac Inotropic Agents
1985 Tanabe Award for Outstanding Research, International Society of Heart Research.
1984-95 Scientific advisory board of Mt Desert Island Biological Lab, Salisbury Cove, ME
1973 Honorary Master of Arts and Sciences, University of Pennsylvania
1970 Sigma Xi Society
1965-67 NIH Special Post-doctoral Fellow
1961-65 NIH Fellowship
1958 Iron Key Academic Honorary Society
1957 BBB Honorary Biological Society
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Memberships in Professional and Scientific Societies: American Association for Advancement of Science
American Heart Association
American Pharmacological Society
American Physiological Society
Cardiac Muscle Society
Biophysical Society
Society of General Physiology
International Society for Heart Research
The Physiological Society, U.K.
Memberships in National Committees and Editorial Boards: 1976-79 Cardiovascular Merit Review Board
1980-84 International Journal of Cardiology
1980-88 Ad Hoc member of cardiovascular program project review grants
1970-99 Referee for Science, American Journal of Physiology, Journal of Physiology,
Circulation Research, and Molecular and Cellular Cardiology, Journal of Clinical Investigation 1997, 1998 Member of NIDA study section on center grants
1997-2004 Ad hoc reviewer for the Israel Science Foundation (Israel Academy of Sciences and Humanities)
2003- NIH study sections, on NRSA fellowships (Member), Biophysics of Neuronal Systems (Ad Hoc), Sudden Death Heart and Lung Institute, PPG (ad hoc).
2019-13 Israel Science foundation reviewer for investigator initiated research grants
2010-2012 Site visit, University of Regensburg, Germany
Directorship of Major International Symposia: 1977 Organizing Chairman, "Biophysical Aspects of Cardiac Muscle," Shiraz, Iran, May
14-16, 1977
1986 Organizing Chairman, Gordon Research Conference on Cardiac Muscle, Holderness, New Hampshire, June 9-13, 1986
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1988 Organizing Chairman, Bayer Centenary Symposium on "The Calcium Channel: Structure, Function and Implications," Stresa, Italy, May 11-14, 1988
1990 Organizing Chairman, AHA Symposium on "Signaling and E-C Coupling in Heart," Dallas, Texas, November 17, 1990
1991 Organizing Chairman, "Intracellular Regulation of Ion Channels," a NATO Advanced Research Workshop, il; Ciocco, Tuscany, Italy, April 26-30, 1991
1992 Organizing Chairman, "From Channels to Cross Bridges," an APS Specialty Symposium, Bar Harbor, ME, July 13-17, 1992
1995 Organizing Vice Chairman, “Molecular and Cellular Mechanisms of Cardiovascular Regulation,” Sendai, Japan, May 10-12, 1995
1996 Scientific Advisory Committee, “The 10th Goldberg Workshop: Analytical and quantitative cardiology from genetics to function,” Haifa, Israel, December 2-5, 1996
1997 Chairman, Late Breaking Science, “Gordon Research Conference,” Colby Sawyer College, New Hampshire, July 7-12, 1997.
2000 Organizing Chair, "Ca2+ Signaling and Cross-Talk in Excitable Tissue" a NATO Advanced Research Workshop, Il Ciocco, Tuscany, Italy, April 25-30, 2000.
2003 Member of Organizing Committee. “Cardiac Engineering: From Genes and Cells to Structure and Function. 2nd Larry and Horti Fairberg Workshop”, Italy, September 2003.
2006 Member of organizing Committee of 3rd Larry & Horti Fairberg Workshop, Charleston SC, May, 2006.
2010 Member of Organizing Committee of “Mechano-Sensory Regulation of the Heart”, Symposium, Oxford, England
2011 Organizing Chairman, “Frontiers in Cardiovascular Regeneration,” Charleston, SC
2013 Member of Scientific advisory board of MEC & Arrhythmia meeting, Oxford, UK.
2018 Organized a major international symposium on Arrhythmia, as a subsection of Joint meeting of Canadian and Cuban Cardiology society on June 6, 2018. Some 250 scientists, cardiologists and students are expected to attend the 3-day meeting. The symposium hopes to establish new formal collaborative program between international scientists and our Center.
Research Positions: 1973 Member of Mount Desert Island Biological Lab where I maintain an active research
lab two months per year.
1980 Director of program in cellular and molecular cardiac electrophysiology. Chief of laboratory composed of 12 professional scientists and physicians and 4 support personnel.
1982-83 Visiting Professor of National Institutes of Health, Okazaki, Japan
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1984 Visiting Professor, University of Leuven-Pennsylvania Exchange Program, Leuven, Belgium
1986-87 Visiting Research Professor at the Max Planck Institute, Division of Neurophysiology, Munich, West Germany.
1988-90 Director, NIH Pre-Doctoral Cardiovascular Training Program at the University of Pennsylvania, with a total of 11 trainees in the program.
1995 Acting Co-Director of the Institute for Cardiovascular Sciences, Georgetown University Medical Center, Washington, DC
2006 Member of organizing Committee and training faculty, for joint training program between Georgetown and Ludwig Maximillian Universities, funded by DFG, Germany.
2008 Director of Cardiac Signaling Center of USC, MUSC, & Clemson University, Charleston, SC
Grant Support:
Active Extramural Grant Support - Principal Investigator (MM), Blue Cross & Blue Shield, 2013-2016, $ 1,666,000. - Collaborator 1R01HL133308-01A1 “Nanowired human cardiac spheroids for heart repair”
Principal Investigator: Dr. Ying Mei
Pending - Principal Investigator (MM), National Science Foundation, PI Martin Morad, 1804727,
Bioengineering molecular markers to detect cardiac calcium signaling in dyadic junctions. 2018-2021.
- Principal Investigator (MM), Department of Defense Defence Health Program, PI Martin Morad, PR171842, Genetic editing provides insights on pathophysiology and pharmacotherapy of congenital arrhythmia. 2018-2021.
- Principal Investigator (MM), NIH grant #R01HL-000000, Bioengineering of a Tissue Based Pacemaker, 2018-2023.
Grant support History (last 10 years) - Principal Investigator (MM) NIH grant #RO1 HL-107600, Suppression of Cardiac calcium
channels by acute hypoxia, 2011-2016, 1.37 million.
- Principal Investigator (MM) NIH grant # RO1 HL-16152-38, Electrophysiology of Neonatal and Adult Heart, 2010-2016, $ 1.86 million (In its 38th year of continuous funding)
- Principal Investigator of Blue Cross/ Blue Shield Cardiovascular Research Grant, 2008-2012, 3.4 Million
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- Mentor, K01 award , Dr. Prosper N’Gouemo, PI. Remodeling of Calcium and Potassium Channels in genetic epilepsy, 2005-2010. ~$850,000
- Principal Investigator of NIH grant #RO1 HL-16152, Electrophysiology of Neonatal and Adult Heart, 2004-2009 $2.214 million.
Training of MD-PhD Students and Post-Doctoral Fellows: I have trained more than 90 scientists, physicians, and cardiologists. Each of these individuals has received a PhD or MD either working in my lab or as a post-doctoral fellow. All trainees have achieved respectable academic and clinical positions in the great centers of learning in the United States, Europe, and Japan. Around 11 individuals are, or have been, directors or chairs of academic departments, and 2 out of 3 who joined pharmaceutical firms are vice presidents of research. A separate list will be provided on request.
Academic Committees:
1975-81 Member, Admissions Committee, University of Pennsylvania
1983-85 Member, Departmental Steering Committee, University of Pennsylvania
1993- Member, Internal Advisory Board, Georgetown Program in Cognitive and Computational Sciences, Georgetown University Medical Center
1993- Member, Interim Executive Committee of the Interdisciplinary Program in Neuroscience, Georgetown University Medical Center
1993-95 Member, Search Committee for the Chair of the Department of Neuroscience, Georgetown University Medical Center
1993-95 Member, Task Force on Research and Graduate Education, Georgetown University
1994- Member, Research Committee, Georgetown University Medical Center
1994- Member, Advisory/Admissions Committee for the Medical Science Training Program, Georgetown University Medical Center
1994- Member, Search Committee, Georgetown Program in Cognitive and Computational Sciences, Georgetown University Medical Center
1994-95 Chairman, Subcommittee on the Future of Research Programs, Georgetown University Medical Center
1994-95 Member, Steering Committee, Institute for Cardiovascular Sciences, Georgetown University Medical Center
1995- Member, Faculty Search Committee, Georgetown University Medical Center
1995-1999 Member of Medical Center Research Committee, Georgetown University Medical Center
1995 Chairman, Research Space Sub-committee, Georgetown University Medical Center
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1996- Member, Graduate Committee, Department of Pharmacology, Georgetown University Medical Center
1997 Chairman, Research Starter grants Sub-committee, Georgetown University
1997- Member, Department of Pharmacology, Doctoral Thesis Defense Committee
1997- Member, Department of Pharmacology, Preliminary Examining Committee
2000 Member, Department of Strategic Committee
2002-2005 Member, Medical School Research Committee
2009 Chair, Search Committee for Cardiac Signaling Faculty
2012 Member, Search Committee for Chair of Pathology at MUSC
2013 Member, Search Committee for Clemson Bioengineering program
Major Teaching Responsibilities: University of Pennsylvania:
- Medical Physiology 100 (1970-90)
- Medical Physiology 101 (Director 1972-74, 1976-78, 1979-81)
- Pathophysiology (Co-director, 1985)
Georgetown University: - Human Physiology (lecturer, 1993)
- Cardiovascular Ion Channel Journal Club (Director, 1994-2008)
- Regulation and Pharmacology of Ion Channels in Heart and Brain (Director, 1995)
- Hale Tufan, 2008-2011, “Cardiac progenitor cells engineered with PIM-1 (CPCeP) develop cardiac phenotypic electrophysiological properties as they integrate with neonatal cardiomyocytes”
- Brooke Damon, MUSC, 2008-2012. Ca2+ signaling in voltage-clamped cardiomyocytes: 1) Shear-stress-induced mitochondrial Ca2+ release, 2) Comparison of E-C coupling parameters in control mice and transgenic mice expressing mutated RyR2, 3) E-C coupling parameters in cardiomyocytes derived from human induced pluripotent stem cells.
- Angelo Da Rosa, USC, 2009-2011, 2012-2013. Hypoxic regulation of cardiac Ca2+ channel: possible role of heme oxygenase as an oxygen sensor.
- Thais Noguerira, MUSC, 2010-2011. Function expression of cloned pacemaker channels (HCN-2) in HEK cells and neonatal cardiomyocytes.
- Juan Jose Arnaiz Cot, MUSC, 2010-2011, 2014-2015. Confocal investigation of Ca2+ sparks and subcellular Ca2+ signals in voltage-clamped cardiomyocytes: 1) Detection of mitochondrial Ca2+ signals using mitycam, 2) Comparison of E-C coupling parameters in control mice and transgenic mice expressing mutated RyR2, 3) E-C coupling parameters in cardiomyocytes derived from human induced pluripotent stem cells.
- Xiao-Hua Zhang, USC, 2010-. Voltage-clamp studies of: 1) Ca2+ driven pacemaker activity in neonatal cardiomyocytes, 2) E-C coupling parameters in control mice and transgenic mice expressing mutated RyR2, 3) cardiomyocytes derived from human induced pluripotent stem cells, and 4) Cardiac progenitor cells with and without expression of Pim-1 kinase and with and without co-cultured neonatal rat cardiomyocytes. TIRF microscopy of (5) mitochondrial Ca2+ signals in cardiomyocytes expressing the targeted Ca2+ probe mitycam.
- Hua Wei, USC, 2012-. Guided cardiac differentiation of cardiac progenitor cells and human induced pluripotent stem cells.
- Yuming Yang, 2012-2013, USC. Oxygen probes and oxygen-sensors in cardiomyocytes.
- Khalid Tai, USC, 2012. Suppression of cardiac calcium channels by acute hypoxia
- Sara Pahlavan, USC, 2012. TIRF studies of mitochondrial Ca2+ signaling in voltage- clamped cardiomyocytes.
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- Jose-Carlos Fernandez-Morales, USC 2014, Regulation of Ca2+ signaling by acute hypoxia and acidosis in rat neonatal cardiomyocytes.
Additional Mentoring
- John Scaringi, preceptor ship 2011 followed by continued long-term internship 2011-2013. Undergraduate student at the College of Charleston. Project: “Development of an ormosil-stabilized ruthenium-based sensor for measurement of oxygen tension in the immediate vicinity of single voltage-clamped cardiac cells”.
- High school Student Ann Lanier, summer internship 2012.
- Tommy Lenz-1st Year MD student, USC, summer 2013
- Gerald Bennett, 1st year Medical Student USC summer 2013
- Alyson Ford- MD student, USC, summer 2013
- Nate Jensen-2013, MD/PhD, summer 2013
- Yoshiya Takayanagi- (2014-2015), Tohoku University School of Medicine, Japan
- Benjamin Van Peel - 1st year MUSC PhD, rotated in 2016
- Kelsey Moore - 1st year MUSC PhD, rotated in 2016
- Gaia Carlson, 1st year med student University of Copenhagen, rotated in summer 2016
- Natalie Kaiser - CofC undergraduate student, 2017
- Charles Kerr- 1st year MUSC PhD, rotated in 2018
Visiting Students
Line Winther Waring, summer internship June 2008-August 2008, Bioengineering Student at the Technical University of Denmark.
Emil Boye Kroman, summer internship June 2008-August 2008, Bioengineering Student at the Technical University of Denmark.
Ronnie Dalsgaard, summer internship June 2008-August 2008, Bioengineering Student at the Technical University of Denmark.
Ane Rømer Sørensen, summer internship June 2009-August 2009, Bioengineering Student at the Technical University of Denmark.
Sofie Therese Hansen, summer internship June 2009-August 2009, Bioengineering Student at the Technical University of Denmark.
Rune Tore Paamand, summer internship June 2009-August 2009, Bioengineering Student at the Technical University of Denmark.
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Takahiro Hayashi, Internship, November 2011- March 2012, Medical student at Sendai University, School of Medicine, Japan.
Katelynn Toomer, summer internship 2012. Undergraduate student at Rowan University. Project: “Development of a fluorescent mitochondrial probe that is sensitive to physiological concentrations of mitochondrial calcium”
Yusuke Tomiyama, Internship, November 2011- March 2012, Medical student at Sendai University, School of Medicine, Japan.
Patents:
1) U.S. patent for: "Methods of treating diseases characterized by hyper excitability of neurons by the family of drugs known as pyrazinolygranadine compounds”. Patent no. 4894376, January 16, 1990, by Morad, M. and Tang, Cha-min.
2) U.S. patent for: "Method and formulations for the therapy of cystic fibrosis, Bartter's syndrome and secretory diarrheas, and for diuretic treatment,” Patent no. 5100647, March 31, 1992, by Agus, Z., Kelepouris, E., and Morad, M.
3) U.S. patent for: “Xanthohumol in antiarrhythmic applications.” Patent no. 20170304220, Filed: April 25, 2017, by Martin Morad, Lars Cleemann, Juan Jose Arnaiz-Cot.
4) U.S. patent for “Bioengineering of a tissue-based pacemaker for the heart” USSN:62/637,588, filed march,02/2018; Provisional patent granted
BIBLIOGRAPHY Books
1. Biophysical Aspects of Cardiac Muscle. Morad M, ed., Academic Press, New York, 1978. ISBN: 978-0-12-506150-6
2. Ca2+ Channel: Structure, Function and Implications. Morad, Nayler, Kazda and Schramm,
eds., Springer Verlag, New York/Berlin, 1988. ISBN: 978-3-642-73914-9
3. Intracellular Regulation of Ion Channels. Morad M, and Agus Z, eds., Springer Verlag, Berlin/Heidelberg, 1992. ISBN: 978-3-642-84628-1
4. Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters.
7. Progress in Biophysics and Molecular Biology of the Beating Heart. Edited by Peter
Kohl, Christian Bollensdorff and Martin Morad. Progress in Biophysics and Molecular Biology. Volume 110, Issues 2–3, Pages 151-396. (October–November 2012). Elsevier. https://www.sciencedirect.com/journal/progress-in-biophysics-and-molecular-biology/vol/110
Film 1. Electricity in Muscle. Encyclopedia Britannica series of films on muscle.
https://archive.org/details/muscleelectricalactivityofcontraction Original Papers 1. Morad M. Excitation-contraction as a possible site for the inotropic action of epinephrine
in cardiac muscle. Doctoral Thesis. State University of New York, New York, 1965. 2. Kavaler F and Morad M. Paradoxical effects of epinephrine on excitation-contraction
coupling in cardiac muscle. Cir. Res. 18:492-501, 1966. https://doi.org/10.1161/01.RES.18.5.492
3. Dudel J, Morad M, And Rudel, R. Contractions of single crayfish muscle fibers induced by controlled changes of membrane potential. Pflugers Arch. Physiol. 299:38 51, 1968. https://doi.org/10.1007/BF00362540
4. Morad M and Trautwein W. The effect of the duration of the action potential on contraction in the mammalian heart muscle. Pflugers Arch. Gen. Physiol. 299:66-82, 1968. https://doi.org/10.1007/BF00362542
5. Morad M. Contracture and catecholamines in mammalian myocardium. Science 166:505-506, 1969. DOI: 10.1126/science.166.3904.505
6. Morad M and Orkand R.K. Excitation-contraction coupling in frog ventricle: Evidence
from voltage-clamp studies. J. Physiol. 219:167-189, 1971. https://doi.org/10.1007/BF00657237
7. Morad M and Rolett El. Relaxing effects of catecholamines on mammalian heart. J. Physiol. 224:537-558, 1972. doi: 10.1113/jphysiol.1972.sp009912
8. Morad M and Goldman Y.E. Excitation-contraction coupling in heart muscle: Membrane
control of development of tension. Prog. Biophys. Mol. Biol. 27:257-313, 1973. https://doi.org/10.1016/0079-6107(73)90008-4
9. Weiss J and Morad M. Single cell layered heart: Electromechanical properties of the heart of Boltenia ovifera. Science 186:750-752, 1974. DOI: 10.1126/science.186.4165.750
10. Greenspan A.M. and Morad M. Electromechanical studies on the inotropic effects of
acetylstrophanthidin in ventricular muscle. J. Physiol. 253:357-384, 1975. doi: 10.1113/jphysiol.1975.sp011194
11. Cleemann L, Dillon S, and Morad M. The sarcomere length tension relation of the single
cell layered heart of "sea potato." MDIBL Bull. 16:8-13, 1976. 12. Kline R and Morad M. Potassium efflux and accumulation in heart muscle. Evidence from
K+ electrode experiments. Biophys J. 16:367-372, 1976. doi: : https://doi.org/10.1016/S0006-3495(76)85694-9
13. Cleemann L and Morad M. Extracellular potassium accumulation and inward going potassium rectification in voltage clamped ventricular muscle. Science 191:90-92, 1976. DOI: 10.1126/science.1246599
14. Salama G and Morad M. Merocyanine 540 as an optical probe of transmembrane electrical
activity in the heart. Science 191:485-487, 1976. doi: 10.1126/science.191.4226.485
15. Morad M and Goldman Y. Clarification of membrane conductance measurements in ventricular heart muscle. J. Mol. Cell. Cardio. 8:169-172, 1976. doi: https://doi.org/10.1016/0022-2828(76)90028-6
16. Weiss J, Goldman Y, and Morad M. Electromechanical properties of the single cell-
layered heart of the tunicate Boltenia ovifera (sea potato). J. Gen. Physiol. 69:503-518, 1976. doi: 10.1085/jgp.68.5.503
17. Goldman Y and Morad M. Measurement of transmembrane potential and current in
cardiac muscle: A new voltage clamp method. J. Physiol. 268:613-654, 1977. doi: 10.1113/jphysiol.1977.sp011875
18. Goldman Y and Morad M. Ionic membrane conductance during the time course of the
cardiac action potential. J. Physiol. 288:655-695, 1977. doi: 10.1113/jphysiol.1977.sp011876
19. Goldman Y and Morad M. Regenerative repolarization of the frog ventricular action
potential: A time and voltage-dependent phenomenon. J. Physiol. 268:575-611, 1977. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283681/pdf/jphysiol00810-0001.pdf
20. Kline R and Morad M. Potassium efflux in heart muscle during activity: Extracellular accumulation and its implications. J. Physiol. 280:537-558, 1978. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1282675/pdf/jphysiol00766-0545.pdf
21. Morad M, Weiss J, and Cleemann L. The inotropic action of adrenaline on cardiac muscle: Does it relax or potentiate tension. Eur. J. Cardiol., 7(suppl):53-62, 1978. PMID: 668768
22. Cleemann L and Morad M. Extracellular potassium accumulation in voltage-clamped frog
ventricular muscle. J. Physiol. 286:83-111, 1979. doi: 10.1113/jphysiol.1979.sp012608 23. Cleemann L and Morad M. Potassium currents in frog ventricular muscle: Evidence from
voltage clamp currents and extracellular K accumulation. J. Physiol. 286:113-143, 1979. doi: 10.1113/jphysiol.1979.sp012609
24. Morad M and Salama G. Optical probes of membrane potential in heart muscle. J.
Physiol. 292:267-295, 1979. doi: 10.1113/jphysiol.1979.sp012850 25. Maylie J, Nunzi Mg, and Morad M. Excitation-contraction coupling in ventricular muscle
of dogfish (Squalus acanthias). MDIBL Bull. 19:84-87, 1979. 26. Maylie J and Morad M. Inotropic effects of adrenaline in dogfish heart (Squalus
acanthias). MDIBL Bull. 19:87-89, 1979. 27. Cleemann L and Morad M. Some aspects of contractility in the sea potato heart. MDIBL
Bull. 19:89-92, 1979.
28. Morad M and Cleemann L. Tunicate heart as a possible model for the vertebrate heart. Fed. Proc. 29:3188-3194, 1980. PMID: 7192220
29. Morad M. Physiological implications of K accumulation in heart muscle. Fed. Proc. 39:1533-1539, 1980. PMID: 6244980
30. Maylie J and Morad M. Ionic and pharmacological characterization of excitation and
contraction in dogfish heart (Squalus acanthias). MDIBL Bull. 20:122-126, 1980. 31. Van Breeman C, Maylie J, and Morad M. The effects of Na+ substitution on net Ca2+
movements and force development in shark atrium. MDIBL Bull. 20:126-128, 1980. 32. Maylie J and Morad M. Possible mechanisms for Ca2+ transport and development of
tension in dogfish heart. MDIBL Bull. 20:128-132, 1980.
33. Morad M, Sanders C, and Weiss J. The inotropic actions of adrenaline on frog ventricular muscle: Relaxing versus potentiating effects. J. Physiol. 311:161-178, 1981. PMCID:PMC1275431
34. Morad M, Reeck S, and Rao M. Potassium chloride versus voltage clamp contractures in
ventricular muscle. Science 211:485-487, 1981. DOI: 10.1126/science.7455687 35. Weiss R and Morad M. Intrinsic birefringence signal preceding the onset of contraction in
36. Dillon S and Morad M. A new laser scanning system for measuring action potential
propagation in the heart. Science 214:453-456, 1981. DOI: 10.1126/science.6974891 37. Maylie J, Morad M, and Weiss J. A study of pace-maker potential in rabbit sinoatrial node:
measurement of potassium activity under voltage-clamp conditions. J. Physiol. 311:161-178, 1981. PMCID: PMC1275404
38. Morad M and Tung L. Ionic events responsible for the cardiac resting and action potential.
Am. J. Cardiol. 49:584-594, 1982. https://doi.org/10.1016/S0002-9149(82)80016-7 39. Martin G and Morad M. Activity-induced potassium accumulation and its uptake in frog
ventricular muscle. J. Physiol. 328:205-227, 1982. doi: 10.1113/jphysiol.1982.sp014260 40. Morad M, Tung L, and Greenspan A. Effect of diltiazem on calcium transport and
development of tension in heart muscle. Am. J. Cardiol. 49:595-601, 1982. https://doi.org/10.1016/S0002-9149(82)80017-9
41. Klitzner T and Morad M. The effects of Ni2+ on ionic currents and tension generation in
42. Klitzner T and Morad M. Excitation-contraction coupling in frog ventricle. Possible Ca2+ transport mechanisms. Pflugers Arch. 398:274-283, 1983. https://doi.org/10.1007/BF00657237
43. Morad M, Goldman YE, and Trentham DR. Rapid photochemical inactivation of Ca2+-antagonists shows that Ca2+ entry directly activates contraction in frog heart. Nature 304:635-638, 1983. doi: 10.1038/304635a0
44. Noma A, Morad M and Irisawa H. Does the "pacemaker current" generate the diastolic
depolarization in the rabbit SA-node cells? Pflugers Arch. 397:190-194, 1983. https://doi.org/10.1007/BF00584356
45. Poledna J and Morad M. Effect of caffeine on the birefringence signal in single muscle fibers and mammalian heart: possible mechanism of action. Pflugers Arch. 397:184-189, 1983. https://doi.org/10.1007/BF00584355
46. Weiss RE and Morad M. Birefringence signals in mammalian and frog myocardium: E-C coupling implications. J. Gen. Physiol. 82:79-117, 1983. PMCID: PMC2228691
47. Tung L and Morad M. Voltage- and frequency-dependent block of diltiazem on the slow
inward current and generation of tension in frog ventricular muscle. Pflugers Arch. 398:189-198, 1983. https://doi.org/10.1007/BF00657150
48. Salama G and Morad M. Diffusion profiles of Na+-fluorescein in frog ventricular muscle. Biophys. J. 43:225-229, 1983. doi: 10.1016/S0006-3495(83)84342-2
49. Cleemann L, Pizarro G, and Morad M. Optical measurements of extracellular Ca-depletion
during a single heartbeat. Science 226:174-177, 1984. DOI: 10.1126/science.6091269 50. Mitra R and Morad M. Ionic currents underlying the action potential of isolated cardiac
myocytes from Squalus acanthias. MDIBL Bull. 24:7-9, 1984. 51. Mitra R and Morad M. Evidence for two populations of Ca2+ channel in ventricular cells of
Squalus acanthias. MDIBL Bull. 24:14-15, 1984. 52. Mitra R, Weiss J, and Morad M. ATP-dependent K+-channel and its possible blockers in
isolated guinea pig ventricular myocytes. MDIBL Bull. 24:54-55, 1984. 53. Maylie J and Morad M. Ionic currents responsible for the generation of pacemaker current
in the rabbit SA-node. J. Physiol. 335:215-236, 1984. doi: 10.1113/jphysiol.1984.sp015415
54. Maylie J and MORAD M. A transient outward current related to development of tension in
elephant seal atrial fibers. J. Physiol. 356: 267-92, 1984. doi: 10.1113/jphysiol.1984.sp015500
55. Pizarro G, Cleemann L, and Morad M. Optical measurements of voltage-dependent Ca2+
influx in frog heart. PNAS 82:1864-1868, 1985. DOI: 10.1073/pnas.82.6.1864 56. Mitra R and Morad M. Ca2+ and Ca2+-activated K+ currents in mammalian gastric smooth
57. Tung L and Morad M. A comparative electrophysiological study of enzymatically isolated single cells and strips of frog ventricle. Pflugers Arch. 405:274-284, 1985. PMID: 2415918
58. Mitra R and Morad M. A uniform enzymatic method for dissociation of myocytes from hearts and stomachs of vertebrates. Am. J. Physiol. 249 (Heart Circ. Physiol. 18):H1056-H1060, 1985. DOI: 10.1152/ajpheart.1985.249.5.H1056
59. Mitra R and Morad M. Two types of calcium channels in guinea pig ventricular myocytes. Proc. Natl. Acad. Sci. 83:5340-5344, 1986. PMCID:PMC323947
60. Carmeliet E, Morad M, Van Der Heyden G, and Vereecke J. Electrophysiological effects of tetracaine in single guinea-pig ventricular myocytes. J. Physiol. 376:143-161, 1986. PMCID: PMC1182791
61. Konnerth A, Lux HD, and Morad M. Proton-induced transformation of calcium channel in
62. Dukes ID, Cox E, Lamp S, and Morad M. Fusion of isolated cardiac ventricular cells from
Ratus ratus. MDIBL Bull. 26:180-183, 1987. 63. Cleemann L, Dukes I, Morad M, Craig J, and Callard G. Effects of estradiol on membrane
properties of cultured goldfish (Carassium auratus) neurons. MDIBL Bull. 26:33-36, 1987. 64. Morad M and Cleemann L. Role of Ca2+ channel in development of tension in heart
muscle. J. Molec. Cell. Cardiol. 19(6):527-553, 1987. https://doi.org/10.1016/S0022-2828(87)80360-7
65. Sutton MSJ and Morad M. Mechanisms of action of diltiazem in isolated human atrial and ventricular myocardium. J. Molec. Cell. Cardiol. 19(5):497-509, 1987. https://doi.org/10.1007/BF01856505
66. Tourneur Y, Mitra R, Morad M, and Rougier O. Activation properties of the inward-rectifying potassium channel on mammalian heart cells. J. Membrane Biol. 97:127-135, 1987. https://doi.org/10.1007/BF01869419
67. Ma Y, Cleemann L, and Morad M. A new study of ammonia sensing microelectrode with a silicone rubber membrane. The Journal of Chemical Sensors (Chinese), 1988.
68. Callewaert G, Cleemann L, and Morad M. Epinephrine enhances Ca2+ current-regulated
Ca2+ release and Ca2+ reuptake in rat ventricular myocytes. PNAS 85:2009-2013, 1988. PMID:3162323
69. Davies NW, Lux HD, and Morad M. Site and mechanism of activation of proton-induced
sodium current in chick dorsal root ganglion neurons. J. Physiol. 400:159-187, 1988. doi: 10.1113/jphysiol.1988.sp017116
70. Tang C-M, Presser F, and Morad M. Amiloride selectively blocks the low threshold (T) calcium channel. Science 240:491-493, 1988. doi: 10.1126/science.2451291
71. Tung L and Morad M. Contractile force of single heart cells compared to muscle strips of frog ventricle. Am. J. Physiol. 255:H111-H120, 1988. DOI: 10.1152/ajpheart.1988.255.1.H111
72. Morad M, Davies N, Ulrich G, and Schultheiss HP. Antibodies against ADP/ATP carrier enhance the calcium current in isolated cardiac myocytes. Am. J. Physiol. 255:H960-H964, 1988. DOI:10.1152/ajpheart.1988.255.4.H960
73. Morad M, Davies NW, Kaplan JH, and Lux HD. Inactivation and block of calcium
channels by photo-released Ca2+ in dorsal root ganglion neurons. Science 241:842-844, 1988. DOI: 10.1126/science.2457253
74. Schultheiss H-P, Kühl U, Janda I, Melzner B, Ulrich G, and Morad M. Antibody-mediated enhancement of calcium permeability in cardiac myocytes. J. Exp. Med. 168:2105-2119, 1988. PMCID:PMC2189146
75. Callewaert G, Hanbauer I, and Morad M. Modulation of calcium channels in cardiac and neuronal cells by an endogenous peptide. Science 243:663-666, 1989. DOI: 10.1126/science.2536955
76. Agus Z, Kelepouris E, Dukes ID, and Morad M. Cytosolic magnesium modulates the availability of calcium channels in mammalian ventricular myocytes. Am. J. Physiol. 256:C452-455, 1989. DOI: 10.1152/ajpcell.1989.256.2.C452
77. Näbauer M, Ellis-Davies G, Kaplan J, and Morad M. Modulation of Ca2+ channel selectivity and cardiac contraction by photorelease of Ca2+. Am. J. Physiol. 256:H916-H920, 1989. DOI: 10.1152/ajpheart.1989.256.3.H916
78. Tang C-M, Dichter M, and Morad M. Quisqualate activates a rapidly inactivating high
79. Näbauer M, Callewaert G, Cleemann L, and Morad M. Regulation of calcium release is
gated by calcium current, not gating charge, in cardiac myocytes. Science 244:800-803, 1989. DOI: 10.1126/science.2543067
80. Katzka Da, And Morad M. Properties of calcium channels in guinea-pig gastric myocytes.
J. of Physiol. 413:175-197, 1989. PMCID: PMC1189095 81. Callewaert G, Cleemann L, and Morad M. Caffeine-induced Ca2+ release activates the
Na+-Ca2+ exchanger in single mammalian cardiac myocytes. Am. J. Physiol. 257:C147-C152, 1989. https://doi.org/10.1152/ajpcell.1989.257.1.C147
82. Schouten VJA and Morad M. Regulation of Ca2+ current in frog ventricular myocytes by
the holding potential, c-AMP and frequency. Pflugers Arch. 415:1-11, 1989. 83. Dukes ID and Morad M. Tedisamil activates transient outward K+ current in rat ventricular
myocytes. Am. J. Physiol. 257:H1746-H1749, 1989. doi: 10.1113/jphysiol.1991.sp018516 84. Morad M, Cleemann L, and Callewaert G. Does voltage affect excitation-contraction
coupling in the heart? Science 246:1640, 1989. DOI: 10.1126/science.2627235
85. Näbauer M and Morad M. Ca2+-induced Ca2+ release as examined by photolysis of caged Ca2+ in single ventricular myocytes. Am. J. Physiol. 258:C189-C193, 1990. DOI: 10.1152/ajpcell.1990.258.1.C189
86. Sorbera LA and Morad M. Atrionaturetic peptide transforms cardiac Na+ channels into
87. Dukes ID and Morad M. Tedisamil blocks the transient and delayed rectifier K+ channels
in mammalian cardiac and glial cells. J. of Pharmacol. & Experimental Therapeutics 254:560-569, 1990. http://jpet.aspetjournals.org/content/254/2/560
88. Tang C-M, Dichter M, and Morad M. Modulation of NMDA channel by extracellular H+. PNAS 87:6445-6449, 1990. PMCID: PMC54551
89. Agus ZS and Morad M. Modulation of cardiac ion channels by magnesium. Annual Review of Physiology, pp. 299-307, 1991. DOI: 10.1146/annurev.ph.53.030191.001503
90. Cleemann L and Morad M. Analysis of role of Ca2+ channel in cardiac excitation
contraction coupling: Evidence from simultaneous measurements of intracellular Ca2+ contraction and Ca2+ current. J. of Physiol. 432:283-312, 1991. PMCID: PMC1181326
91. Dukes ID and Morad M. The transient K+ current in rat ventricular myocytes: Evaluation of its Ca2+- and Na+-dependence. J. of Physiol. 435:395-420, 1991. PMCID:PMC1181468
92. Callewaert G, Johnson RG, and Morad M. Regulation of the secretory response in bovine chromaffin cells. Am. J. of Physiol. 260 (Cell Physiol. 29):C851-C860, 1991. DOI: 10.1152/ajpcell.1991.260.4.C851
93. Mitra RL and Morad M. Permeance of Cs+ and Rb+ through the inwardly rectifying K+
channel in guinea-pig ventricular myocytes. J. Membrane Bio. 122:33-42, 1991. DOI: 10.1007/BF01872737
94. Sorbera LA, and MORAD M. Atrionaturetic peptide and Ca2+-conducting sodium channels. Science 252:449-452, 1991. PMID: 1850170
95. Agus Z, Dukes ID, and Morad M. Divalent cations modulate the transient outward current in rat ventricular myocytes. Am. J. of Physiol. 261(Cell Physiol. 30):H1344-H1349, 1991. DOI: 10.1152/ajpcell.1991.261.2.C310
96. Sorbera LA and Morad M. Modulation of cardiac sodium channels by cAMP receptors on
the myocyte surface. Science 253:1286-1286, 1991. DOI: 10.1126/science.1653970
97. Sham JS, Jones, LR, and Morad M. Phospholamban mediates the relaxant effect of ß-adrenergic agonists in mammalian ventricular myocytes. Am. J. of Physiol. 261(Heart & Cellular Physiol. 30):H1344-H1349, 1991. DOI:10.1152/ajpheart.1991.261.4.H1344
98. Sham JSK, Cleemann L, and Morad M. Gating of cardiac release channels by Na+ current
and Na+Ca2+ exchange. Science 255:850-853, 1992. DOI: 10.1126/science.1311127
99. Katzka DA, Cox R, Davidoff AJ, and Morad M. Permeation of divalent cations through the Ca2+ channel of rabbit portal vein myocytes. Am. J. of Physiol. 262:H326-H330, 1992. DOI: 10.1152/ajpheart.1992.262.2.H326
100. Morad M and Dukes ID. The mode of action of tedisamil on voltage-dependent K+
channels. J. Cardiovascular Drug and Therapy 6:321-327, 1992. https://doi.org/10.1007/BF00051017
101. Cox RH, Katzka D, and Morad M. Characteristics of calcium currents in rabbit portal vein myocytes. Am. J. Physiol. 263:H453-H463, 1992. DOI: 10.1152/ajpheart.1992.263.2.H453
102. Näbauer M and Morad M. Modulation of contraction by intracellular Na+ via Na+Ca2+ exchange in single shark (Squalus acanthias) ventricular myocytes. J. Physiol. 457:627-637, 1992. PMCID: PMC1175751
103. Gandia L, Garcia AG, and Morad M. ATP modulation of calcium channels in chromaffin cells. J. Physiol. 470:55-72, 1993. PMCID: PMC1143906
104. Lacinova L, Cleemann L, and Morad M. Ca2+ channel modulating effects of heparin in mammalian cardiac myocytes. J. Physiol. 465:181-201, 1993. PMCID: PMC1175425
105. Hatem SN, Sham JSK, and Morad M. Enhanced Na+-Ca2+ exchange activity in
106. Fan J, Cleemann L, Lara B, Gandia L, and Morad M. Ionic currents in adrenal chromaffin cells from Ratus Ratus in primary culture. MDIBL Bulletin 33:24-25, 1994.
107. Cleemann L, Fan J, Garcia A, and Morad M. Secretion in adrenal chromaffin cells from
Ratus Ratus is gated by L-type Ca2+ channels. MDIBL Bulletin 33:26-28, 1994.
108. Sham JSK, Cleemann L, and Morad M. Functional coupling of Ca2+ channels and ryanodine receptors in cardiac myocytes. PNAS 92:121-125, 1995. PMCID: PMC42829
109. Hatem SN, Sweeten T, Vetter V, and Morad M. Evidence for presence of Ca2+ channel-gated Ca2+ stores in neonatal human atrial myocytes. Am. J. Physiol. 268:H1195-H1201, 1995. DOI: 10.1152/ajpheart.1995.268.3.H1195
110. Berul CI and Morad M. Regulation of potassium channels by nonsedating antihistamines.
111. Adachi-Akahane S, Cleemann L, and Morad M. Ca2+-cross signaling between DHP- and Ryanodine-receptors in cardiomyocytes. Heart Vessels 9:163-166, 1995.
112. Sham JSK, Hatem SN, and Morad M. Species differences in the activity of the Na+-Ca2+ exchanger in mammalian cardiac myocytes. J. Physiol. 488.3:623-631, 1995. PMCID: PMC1156729
113. Maylie J and Morad M. Evaluation of T- and L-type Ca2+ currents in shark ventricular myocytes. Am. J. Physiol. 269:H1695-1703, 1995. DOI: 10.1152/ajpheart.1995.269.5.H1695
114. Morad M, Fan J, and Shuba YM. Cardiac E-C Coupling: temporal modulation of preferred
Ca2+ influx pathways. Heart and Vessels 380, 1995. 115. Fan J, Shuba Y, and Morad M. Regulation of cardiac sodium-calcium exchanger by β-
adrenergic agonists. PNAS. 93:5527-5532, 1996. PMCID: PMC39280 116. Maylie J, Harvey D, Van Dolah FM, and Morad M. Maitotoxin activates a non-selective
cation channel in cardiac myocytes of Ratus Norvegicus and Squalus Acanthias. MDIBL Bull. 35:7-10, 1996.
117. Fan J, Cleemann L, and Morad M. An exocytotic release pathway triggered by Ca2+ influx
via Ca2+ channels in chromaffin cells from Ratus Norvegicus. MDIBL Bull. 35:11-14, 1996.
118. Suzuki YJ, Monterubio J, Hughes Ba, Cleemann L, Abernethy DR, and Morad M.
Hydrogen peroxide regulates the ryanodine receptor and the Na+-Ca2+ exchanger in rat (Ratus Norvegicus) cardiac myocytes. MDIBL Bull. 35:33-34, 1996.
119. Adachi-Akahane S, Cleemann L, and Morad M. Cross-signaling between L-type Ca2+
channels and ryanodine-receptors in rat ventricular myocytes. J. Gen. Physiol. 108:435-454, 1996. http://jgp.rupress.org/content/jgp/108/5/435.full.pdf
120. Shuba YM, Naidenov VG, and Morad M. Glass-funnel technique for the recording of membrane currents and intracellular perfusion of Xenopus oocytes. Pflügers Arch. 432:562-570, 1996. https://doi.org/10.1007/s004240050170
121. Shuba Y, Naidenov VG, and Morad M. cAMP-dependent regulation of Ca2+ channels expressed in xenopus oocytes. Neurophysiology 29:40-49, 1997. https://doi.org/10.1007/BF02463184
122. Berul CI, Sweeten T, Vetter VL, and Morad M. Lack of cystic fibrosis transmembrane regulator-type chloride current in pediatric human atrial myocytes. Life Sciences. 60(3):189-197, 1997. https://doi.org/10.1016/S0024-3205(96)00615-7
123. Ko CM, Ducic I, Fan J, Shuba YM, and Morad M. Suppression of mammalian K+ channel
family by ebastine. JPET 281(1):233-244, 1997. http://jpet.aspetjournals.org/content/jpet/281/1/233.full.pdf
124. Adachi-Akahane S, Lu L, Li Z, Frank JS, Philipson KD, and Morad M. Calcium signaling in transgenic mice overexpressing cardiac Na+-Ca2+ exchanger. J Gen Physiol. 109:717-729, 1997. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217045/
125. Lara B, Lopez MG, Villarroya M, Gandia L, Cleemann L, Morad M and Garcia Ag. A caffeine-sensitive Ca2+ store modulates K+-evoked secretion in chromaffin cells. Am. J. Physiol. 272:C1211-C1221, 1997. doi: 10.1152/ajpcell.1997.272.4.C1211
126. Ducic I, Ko CM, Shuba Y, and Morad M. Comparative effects of loratadine and
terfenadine on cardiac K+ channels. J of Cardiovasc Pharm. 30(1):42-54, 1997. https://insights.ovid.com/pubmed?pmid=9268220
127. Suzuki YJ, Cleemann L, Abernethy DA, and Morad M. Glutathione is a co-factor for H202-mediated stimulation of Ca2+-induced Ca2+release in cardiac myocytes. In Press. Free Radical Biology and Medicine 24(2): 318-325, 1998. https://doi.org/10.1016/S0891-5849(97)00227-X
128. Soldatov NM, Oz M, O’Brien KA, Abernethy DR, and Morad M. Molecular
determinants of L-type Ca2+ channel inactivation. J of Biological Chemistry 273:957-963, 1998. doi: 10.1074/jbc.273.2.957
129. Jones LR, Suzuki YJ, Wang W, Kobayashi YM, Cleemann L, and Morad M. Regulation of
130. Oz M, Soldatov N, Melia M, and MORAD M. Functional coupling of L-Type Ca2+-
Channel and angiotensin AtIA receptor co-expressed in Xenopus oocytes. Molec. Pharm. 54:1106-1112, 1998. https://doi.org/10.1124/mol.54.6.1106
131. Cleemann L, Wang W, and Morad M. Two-dimensional confocal images of organization, density, and gating of focal Ca2+ release sites in rat cardiac myocytes. Proc. Natl. Acad. Sci. USA 95:10984-10989, September 1998. http://www.pnas.org/content/pnas/95/18/10984.full.pdf
132. Shuba Y, Iwata T, Naidenov V, OZ M, Sandberg K, Draev A, Carafoli E, and Morad M. A novel molecular determinant for cAMP-dependent regulation of the frog heart Na+ -Ca2+ exchanger. J. of Biological Chemistry 273:18819-18825, 1998. doi: 10.1074/jbc.273.30.18819
132. Adachi-Akahane S, Cleemann L, and Morad M. Bay K 8644 modifies Ca2+ cross-
signaling between DHP- and ryanodine receptors in rat ventricular myocytes. Am. J. Physiol. 276:H1178-H1188, April 1999. https://doi.org/10.1152/ajpheart.1999.276.4.H1178
133. Suzuki Y, Wang W, and Morad M. Modulation of Ca2+ channel-gated Ca2+ release by W-7 in cardiac myocytes. Cell Calcium. 25(3):191-198, 1999. doi: 10.1054/ceca.1998.0019
135. Dorfman J, Cleemann L, and Morad M. Caffeine regulation of cardiac contractility in
136. Zhang J, Xiao Y, Abdrahmanova G, Cleemann L, Kellar KJ, and Morad M. Activation
and Ca2+ permeation of stably transfected α3/β4 neuronal nicotinic acetylcholine receptor. Mol. Pharmacology. 55:970-981, 1999. doi: https://doi.org/10.1124/mol.55.6.970
134. Suzuki YJ, Ikeda T, Shuai-Chen SS, Kobayashi YM, Morad M, Jones LR,
Blumberg JB. Regulation of GATA-4 and AP-1 in transgenic mice overexpressing cardiac calsequestrin. Cell Calcium. 25:401-407, 1999. doi:10.1054/ceca.1999.0037
135. Morad M, Suzuki YJ, and Okabe E. Redox regulation of cardiac and skeletal
sarcoplasmic reticulum. Antioxidant and Redox Signaling, 2:1-3, 2000. doi: 10.1089/ars.2000.2.1-1
136. Morad M and Suzuki YJ. Redox regulation of cardiac muscle calcium signaling.
Antioxidant and Redox Signaling, 2:65-71, 2000. doi: 10.1089/ars.2000.2.1-65 137. Wang W, Cleemann L, and Morad M. Modulation of focal and global Ca2+ release in
calsequestrin-overexpressing mouse cardiomyocytes. The Journal of Physiology, 524: 399-414, 2000. http://bio.vtn2.com/Bull-MDIBL/Bull-00/main-sections/3titles-parent.html
138. Woo S-H, Dorfman A, Cleemann L, and Morad M. Bimodal regulation of Na+-Ca2+ exchanger in shark heart. MDIBL Bulletin. 39, 2000.
139. Knollmann BC, Knollmann BEC, Weismann NJ, Jones LR, and Morad M. Remodeling
of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing Calsequestrin. Journal of Physiology, 525:483-498, 2000. doi: 10.1111/j.1469-7793.2000.t01-1-00483.x
140. Soldatov NM, Zhenochin S, Albanna B, Abernethy DR, and Morad M. New Molecular
Determinant for Inactivation of the Human L-Type α1C Ca2+ Channel. Journal of Membrane Biology, 177:129-135, 2000. DOI: 10.1007/s002320001106
141. Woo S-H, and Morad M., Bimodal regulation of Na+-Ca2+ exchanger by β–adrenergic
142. Knollmann B, Blatt SA, De Freitas F, Miller T, Bell M, Housmans PR, Weismann NJ,
Morad M, and Potter JD. Cardiac performance depends on the inotropic state of transgenic mice expressing an FHC-linked troponin T (179N) mutation, Journal Biological Chemistry, 276 (no.13):10039-10048), 2001. doi: 10.1074/jbc.M006745200
146. Abdrahmanova G, Dorfman J, Xiao J, and Morad M. Protons enhance the gating kinetics
of the α3/β4 neuronal nicotinic acetylcholine receptor by increasing its apparent affinity to agonists. Mol. Pharmacology 61:369-378, 2002. DOI: https://doi.org/10.1124/mol.61.2.369
147. Woo S-H, Cleemann L. and Morad M. Control of focal and local Ca2+ releases by Ca2+
current in rat atrial myocytes: evidence from 2D confocal imaging. Journal of Physiology 543:439-453, 2002. doi: 10.1113/jphysiol.2002.024190
148. Sasse P, Cleemann L, Fleischmann BK, Hescheler J, and Morad M. Subcellular
localization of intracellular calcium stores in embryonic mouse cardiomyocytes. M.D.I.B.L. Bulletin, 41:84-87, 2002. https://mdibl.org/bulletin/bulletin_2002.pdf
149. Degtiar V, Jones E, Chau M, Cleemann L, and Morad M. TIRF imaging of focal Ca2+
release in voltage-clamped atrial and ventricular myocytes M.D.I.B.L. Bulletin, 41:92-95, 2002. https://mdibl.org/bulletin/bulletin_2002.pdf
150. Woo S-H, Cleemann L and Morad M. Spatiotemporal characteristics of junctional and
nonjunctional focal Ca2+ release in rat atrial myocytes. Circulation Research 92:e1-e11, 2003. doi: https://doi.org/10.1161/01
151. He L-P., Cleemann L., Soldatov N.M., and Morad M. Molecular determinants of cAMP-mediated regulation of Na+-Ca2+ exchanger expressed in human cell lines. Journal of Physiology, 546:677-689, 2003. doi: 10.1113/jphysiol.2002.036426
152. N’gouemo P, and Morad M. Voltage-Gated Calcium Channels in Adult Rat Inferior
153. N’gouemo P, and Morad M. Ethanol withdrawal seizure susceptibility is associated with
upregulation of L- and P-type Ca2+ channel current in inferior colliculus neurons. Neuropharmacology, 45 429-437, 2003. doi: https://doi.org/10.1016/S0028-3908(03)00191-6
Fabritz L, Potter JD, and Morad M. Familial Hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling. Circulation Research, 92: 428-436, 2003. doi: https://doi.org/10.1161/01.RES.0000059562.91384.1A
155. Woo SH, Soldatov, NM and Morad M., Modulation of Ca2+ signaling in rat atrial myocytes: possible role of the alpha 1C terminal. Journal of Physiology, 552:437-447, 2003. doi: 10.1113/jphysiol.2003.048330
156. Abdrahmanova G, Cleemann L, Lindstrom J, and Morad M. Differential modulation of b2 and b4 subunits of human neuronal nicotinic AChRs by acidification. Molecular Pharmacology, 66:347-355, 2004. http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1931098
157. Morad M, and Chau M., Learning about cardiac calcium signaling from genetic engineering. Ann. N.Y. Acad. Sci., 1015:1-15, 2004. DOI: 10.1196/annals.1302.001. doi: 10.1196/annals.1302.001
158. Day, R. M., Nagase, H., Y.H., L., Kraev, A., Cleemann, L. and Morad, M. Sequencing the cardiac Na+-Ca2+ exchanger of the spiny dogfish shark (Squalus acanthias). M.D.I.B.L. Bulletin 44, 80-83, 2004. https://mdibl.org/bulletin/bulletin_2004.pdf
159. Cleemann L, Kranz, KE, Vedel-Larsen E and Morad M. Measurements of local pH-transients in K+ depolarized PC12 cells. MDIBL Bulletin, 45, 2005. https://mdibl.org/bulletin/bulletin_2005.pdf
160. Morad M, Cleemann, L and Knollmann BC. Triadin: the new player on the excitation-contraction coupling block. Circulation Research, 96:607-6009, 2005. http://circres.ahajournals.org/content/96/6/607.long
161. Morad M, Javaheri A, Risius T. Multimodality of Calcium signaling in rat atrial myocytes.
Ann. N.Y. Acad. Sci., 1047:112-121, 2005. doi: 10.1196/annals.1341.010
162. Belmonte S, Wang J, and Morad M. Effect of isoproterenol and nifedipine on electrically stimulated Cai-transients in ventricular myocytes of Squalus acanthias. M.D.I.B.L. Bulletin 45:0-0, 2005. https://mdibl.org/bulletin/bulletin_2005.pdf
163. Woo S-H, Cleemann L, and Morad M. Diversity of atrial local calcium signaling: evidence from 2-D confocal imaging in Ca-buffered rat atrial myocytes. J. Physiol., 567:905-921, 2005. doi: 10.1113/jphysiol.2005.092270
164. Morad M. and Soldatov N. Calcium channel inactivation: Possible role in signal transduction and Calcium signaling. Cell Calcium, 38:223-231, 2005. https://doi.org/10.1016/j.ceca.2005.06.027
165. N’gouemo P, Yasuda RP, Morad M. Ethanol withdrawal is accompanied by down
regulation of calcium channel alpha 1B subunit in rat inferior colliculus neurons. Brain Res. 1108:260-220, 2006. https://doi.org/10.1016/j.brainres.2006.06.028
166. Cleemann L, Belmonte S, Solvadottir AE, Andreasen G, Pihl MJ and Morad M. Bimodal
adrenergic regulation of Na+-Ca2+ exchanger in Ca2+-buffered native ventricular myocytes from the spiny dogfish shark (Squalus acanthias). MDIBL Bulletin 45:0-0, 2006. https://mdibl.org/bulletin/bulletin_2006.pdf
167. Day, R.M., Janowski, E., Movafagh, S., Heyrana, K., Lee, J., Nagase, H., Kraev, A., Roder,
J.D.,Williams, S.A., Kiilerich-Hansen, K., Cleemann, L., and Morad, M. (2006) Cloning and functional expression of the cardiac Na+-Ca2+ exchanger of the spiny dogfish shark (Squalus acanthias). M.D.I.B.L. Bulletin 45, 29-32. https://mdibl.org/bulletin/bulletin_2006.pdf
168. Morad M, Javaheri A, Risius T & Belmonte S. (2006). Multimodality of Ca2+ Signaling in Rat Atrial Myocytes. In The Communicative Cardiac Cell, ed. Sideman S, Beyar R & Landesberg A, pp. 112-121. Annals of the New York Academy of Sciences, New York. doi: 10.1196/annals.1341.010
169. Woo, S.H., T. Risius, and Morad M. (2007) Modulation of local Ca2+ release sites by
rapid fluid puffing in rat atrial myocytes. Cell Calcium, 2007 41, 397-403. https://doi.org/10.1016/j.ceca.2006.09.005
170. Janowski, E, Day, R, Kraev, A, Cleemann, L, & Martin Morad, M (2007). Structure and function of the cardiac Na+-Ca2+ exchanger of the spiny dogfish shark (Squalus acanthias). MDIBL Bulletin 46, 29-32. https://mdibl.org/bulletin/bulletin_2007.pdf
171. Hermann, E., Morad, M., & Cleemann, L. (2007) Resolution of Ca2+ changes, pH changes, and exocytosis with TIRF microscopy in cultured PC-12 cells. MDIBL Bulletin 46, 33-35.https://mdibl.org/bulletin/bulletin_2007.pdf
172. Sassed, P., Zhang, J., Cleemann, L., Morad, M., Hescheler, J., & Fleischmann, B. K. (2007). Intracellular Ca2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells. J Gen Physiol 130, 133-144. doi: 10.1085/jgp.200609575
173. Shuba YM, Dietrich CJ, Oermann E, Cleemann L, and Morad M. (2008) Local
extracellular acidification caused by Ca(2+)-dependent exocytosis in PC12 cells. Cell Calcium, Aug; 44(2):220-229. https://doi.org/10.1016/j.ceca.2007.12.003
174. Belmonte S and Morad M. (2008) 'Pressure-flow'-triggered intracellular Ca2+ transients in
rat cardiac myocytes: possible mechanisms and role of mitochondria. J Physiol 586: 1379-1397. doi: 10.1113/jphysiol.2007.149294
175. Belmonte S and Morad M. (2008) Shear fluid-induced Ca2+ release and the role of
mitochondria in rat cardiac myocytes. Ann N Y Acad Sci 1123: 58-63. doi:10.1196/annals.1420.007
176. Cleemann L, Plesiu A, Top Knudsen A, and Morad M. (2008) Isometric force development in strips of the systemic heart of the Atlantic hagfish (Myxine glutinosa). MDIBL Bulletin 47: 37-39. https://mdibl.org/bulletin/bulletin_2008.pdf
177. Haviland S, Cleemann L, and Morad M. (2008) The cardiac Na+-Ca2+ exchanger of the spiny dogfish shark (Squalus acanthias) supports rapid Ca2+ efflux when expressed in murine HL-1 cells of cardiac phenotype. MDIBL Bulletin. 47: 33-36. https://mdibl.org/bulletin/bulletin_2008.pdf
178. N’Gouemo P, Faingold CL, and Morad M. (2009) Calcium channel dysfunction in inferior colliculus neurons of the genetically epilepsy-prone rat. Neuropharmacology 56: 665-675. doi: 10.1016/j.neuropharm.2008.11.005
179. Janowski E, Day R, Kraev A, Roder JC, Cleemann L, and Morad M. (2009) Beta-adrenergic regulation of a novel isoform of NCX: sequence and expression of shark heart NCX in human kidney cells. Am. J. Physiol. 296: H1994-2006. doi: 10.1152/ajpheart.00038.2009
180. Movafagh S, and Morad M. L-type Ca channel as cardiac oxygen sensor. Ann. N.Y. Acad.
Sci. 188:153-158, 2010. doi: 10.1111/j.1749-6632.2009.05095.x 181. Dietrich, C.J. and M. Morad. Synaptic acidification enhances GABAA signaling. J
Neurosci, 2010. 30(47): p. 16044-52. doi: 10.1523/JNEUROSCI.6364-09.2010
182. Rosa AO, Hansen ST, Paamand RT, Cleemann L, & Morad M. (2010) Differential effects of hypoxia on K+ channels in ventricular cardiomyocytes from rat (Rattus norvegicus) and shark (Squalus acanthias). M.D.I.B.L. Bulletin 49:64-67. https://mdibl.org/bulletin/bulletin_2010.pdf
183. Cleemann L, Haviland S, Dalsgaard R, & Morad M (2010) Cholinergic and adrenergic responses of beating strips from the systemic heart of the Atlantic hagfish (Myxine glutinosa). M.D.I.B.L. Bulletin 49:13-16. https://mdibl.org/bulletin/bulletin_2010.pdf
184. Movafagh, S., L. Cleemann, and M. Morad, Regulation of cardiac Ca(2+) channel by extracellular Na(+) (2011). Cell Calcium, 49(3): p. 162-73. https://doi.org/10.1016/j.ceca.2011.01.008
185. Morad, M., L. Cleemann, and D.R. Menick (2011). NCX1 phosphorylation dilemma: a
little closer to resolution. Focus on "Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A". Am J Physiol Cell Physiol, 2011. 300(5): p. C970-3. DOI: 10.1152/ajpcell.00064.2011
186. Janowski, E., Pastel, R., and Morad, M (2011). c-Jun is required for TGF-beta-mediated
cellular migration via nuclear Ca(2+) signaling. Int J Biochem Cell Biol. 43(8): p. 1104-1113. https://doi.org/10.1016/j.biocel.2011.03.011
187. Fatima A, Xu G, Shao K, Papadopoulos S, Lehmann M, Arnaiz-Cot JJ, Rosa AO,
Nguemo F, Matzkies M, Dittmann S, Stone SL, Linke M, Zechner U, Beyer V, Hennies HC, Rosenkranz S, Klauke B, Parwani AS, Haverkamp W, Pfitzer G, Farr M, Cleemann L, Morad M, Milting H, Hescheler J & Saric T. (2011). In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells. Cell Physiol Biochem 28, 579-592. doi: 10.1159/000335753
188. Kohl P, Bollensdorff C & Morad M. (2012). Progress in biophysics and molecular
biology of the beating heart. Prog Biophys Mol Biol 110, 151-153. DOI: 10.1016/j.pbiomolbio.2012.08.007
189. Rosa AO, Movafagh S, Cleemann L & Morad M. (2012). Hypoxic regulation of cardiac Ca2+ channel: possible role of haem oxygenase. J Physiol 590, 4223-4237. doi: 10.1113/jphysiol.2012.236570
190. Tufan H, Zhang XH, Haghshenas N, Sussman MA, Cleemann L & Morad M. (2012).
Cardiac progenitor cells engineered with Pim-1 (CPCeP) develop cardiac phenotypic electrophysiological properties as they are co-cultured with neonatal myocytes. J Mol Cell Cardiol 53, 695-706. doi: 10.1016/j.yjmcc.2012.08.008
191. Rosa AO, Yamaguchi N, Morad M. (2013). Mechanical regulation of native and the
Morad, M. (2013). Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects. Cell Calcium 54, 57-70. doi: 10.1016/j.ceca.2013.04.004
193. Cot, J.J., Damon, B., Zhang, X.H., Stone, S., Cleemann, L., Yamaguchi, N., Morad, M. (2013). Cardiac calcium signaling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor. J. Physiol. 59, 4287-4299. doi: 10.1113/jphysiol.2013.256123
194. Scaringi, J.A., Rosa, A.O, Morad, M., Cleemann, L. (2013). A new method to detect
rapid oxygen changes around cells: How quickly do calcium channels sense oxygen in cardiomyocytes? Journal of Applied Physiology, 115, 1855-1861. doi: 10.1152/japplphysiol.00770.2013
195. Haviland, S., Cleemann, L., Kettlewell, S., Smith, G.L., Morad, M. (2014). Diversity of mitochondrial Ca2+signaling in rat neonatal cardiomyocytes: Evidence from a genetically directed Ca2+probe mitycam-E31, Cell Calcium, 56, 133-46. doi: 10.1016/j.ceca.2014.06.001
196. N'Gouemo P, Morad M. (2013) Alcohol withdrawal is associated with a down regulation of large-conductance Ca-activated K channels in rat inferior colliculus neurons. Psychopharmacology (Berl). 231,2009-2018. doi: 10.1007/s00213-013-3346-8
198. Helassa, N., Zhang, X.H., Conte, I., Scaringi, J., Eposito, E., Bradley, J., Carter, T., Ogden, D., Morad, M., Torok, K. (2015) Fast-response calmodulin-based fluorescent
199. Cot, J.J, Cleeman, L., Morad, M. (2017) Xanthohumol modulates calcium signaling in
rat ventricular myocytes: possible antiarrhythmic properties. Journal of Pharmacology and Experimental Therapeutics, 360, 239-248. DOI: https://doi.org/10.1124/jpet.116.236588
200. Morad, M., Zhang, X.H. (2017) Mechanisms of spontaneous pacing: sinoatrial nodal cells, neonatal cardiomyocytes, and human stem cell derived cardiomyocytes. Canadian Journal of Physiology and Pharmacology, 95, 1100-1107. https://doi.org/10.1139/cjpp-2016-0743
201. Pahlavan, S., Morad, M. (2017) Total internal reflectance fluorescence imaging of genetically engineered ryanodine receptor-targeted Ca2+ probes in rat ventricular myocytes. Cell Calcium, 66, 98-110. https://doi.org/10.1016/j.ceca.2017.07.003
202. Fernandez-Morales, J.C., Morad, M. (2017) Regulation of Ca2+ signaling by acute
hypoxia and acidosis in rat neonatl cardiomyocytes. Journal of Molecular and Cellular Cardiology, 114, 58-71. https://doi.org/10.1016/j.yjmcc.2017.10.004
57 short peer-reviewed papers Bulletin, MDIBL are not included in this list. Chapters and Reviews 1. Morad M, and Greenspan Am. Excitation-contraction coupling as a possible site for the
action of digitalis on heart muscle. In: LS Dreifus and W Likoff, eds., Cardiac Arrhythmias, Grune & Stratton, Inc. pp. 479-489, 1973.
2. Cleemann L, and Morad M. Potassium currents in ventricular muscle. In: M Morad, ed.,
Biophysical Aspects of Cardiac Muscle, Academic Press, New York, pp. 153-184, 1978. 3. Morad M, and Klitzner T. A calcium transport system for activation of tension in frog
ventricular muscle. In: M Morad, ed., Biophysical Aspects of Cardiac Muscle, Academic Press, New York, pp. 285-305, 1978.
4. Weiss J, Maylie J, Morad M. Pacemaker currents and paracellular K+ accumulation in
rabbit sinoatrial node. In: A Scarpa, and I Lee, eds., Frontiers of Biological Sciences, Vol. 2, pp. 1417-1425, 1978.
5. Morad M and Martin G. K+ accumulation and its physiological regulatory role in heart
muscle. In: Ion Selective Microelectrodes and their use in Excitable Tissues. Academic Press, New York, pp. 285-298, 1981.
6. Morad M. Ionic mechanisms mediating the inotropic and relaxant effects of adrenaline on the heart muscle. In: RA Reimersma, and MF Oliver, eds., Catecholamines in the Non-ischaemic Myocardium, Elsevier Press, pp. 113-135, 1982.
7. Tung L, and Morad M. Electrophysiological studies with Ca2+ entry blockers. In: Ca2+
Entry Blockers, Adenosine, and Neurohumors (Chapter 2). GF Merril & HR Weiss, eds., Urban and Schwarzengerg, pp. 19-37, 1983.
8. Cleemann L, and Morad M. Antipyrylazo III measurements of extracellular Ca depletion
in heart muscle. In: Ion Measurements in Physiology and Medicine. W Kessler, ed., Springer-Verlag, 1985.
9. Morad M, Dillon S, and Weiss J. An acousto-optically steered laser scanning system for
measurement of action potential spread in intact heart. In: P DeWeer and BM Salzberg, eds., Optical Methods in Cell Physiology. Weiley and Sons, 1986.
10. Morad M, and Rendt, J. Rapid photoinactivation of nifedipine in heart muscle:
implications on the kinetics and role of Ca2+ channel in generation of tension. In: U Heinemann and E Neher, eds., J. Exp. Brain Research (suppl), Ca2+ Electrogenesis and Neuronal Function, Springer-Verlag, pp. 112-123, 1986.
11. Morad M, Näbauer M, and Schultheiss H-P. Antibodies and autoantibodies against
ADP/ATP carrier enhance calcium current in isolated ventricular myocytes. In: H-P Schulteiss, ed., New Concepts in Viral Heart Disease, Springer-Verlag, pp. 236-242, 1988.
12. Morad M, and Lux Hd. Proton-induced transformation of Ca2+ channel in dorsal root
ganglion neurons. In: A Grinnell, DL Armstrong and MB Jackson, eds., Calcium and Ion Channel Modulation, Plenum Publishing, New York, pp. 53-62, 1988.
13. Morad M. Proton-induced transformation in gating and selectivity of the Ca2+ channel in
neurons. In: Proceedings of the Ciba Foundation Symposium on Proton Passage Across Cell Membranes. John Wiley & Sons Inc., New York: pp. 187-200, 1988.
14. Morad M, and Callewaert G. Proton-induced transformation of Ca2+ channel: possible
mechanism and physiological implications. In: Proceedings of 20th Annual Symposium, Puerto Rico Health Sciences Journal 7(2):113-115, 1988.
15. Hanbauer I, Sanna E, Callewaert G, and Morad M. An endogenous purified glycopeptide
modulates Ca2+ channels in neurons and cardiac myocytes. In: Morad, Nayler, Kazda, and Schramm, eds., Calcium Channel: Structure, Function and Implications. Springer-Verlag, New York, Berlin, pp. 611-618, 1988.
16. Morad M, and Callewaert G. Proton-induced transformation of Ca2+ channel: possible
mechanism and physiological implications. In: Morad, Nayler, Kazda, and Schramm, eds., Calcium Channel: Structure, Function and Implications. Springer Verlag, New York, Berlin, pp. 71-80, 1988.
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17. Schulteiss H-P, Janda I, Kuhl U, Ulrich G, and Morad M. Antibodies against the
ADP/ATP carrier interact with the Ca channel and induce cytotoxicity by enhancement of calcium permeability. In: Morad, Nayler, Kazda, and Schramm, eds., Calcium Channel: Structure, Function and Implications, Springer Verlag, New York, Berlin, pp. 619-631, 1988.
18. Morad M, Näbauer M, and Cleemann L. Ca2+ release channel of cardiac sarcoplasmic
reticulum is regulated by Ca2+ influx through the sarcolemmal Ca2+ channel. In: Kazuo, Yamada, Shibata, eds., Recent Advances in Ca2+ Channel and Ca2+ Antagonists, Pergmon Press, Oxford, pp. 42-50, 1989.
19. Morad M. Regulation of Ca2+ release in mammalian cardiac myocytes. In: Vereecke, van
Bogart, and Verdonk, eds., Ionic Currents and Ischemia, Leuven University Press, Leuven, pp. 469-476, 1990.
20. Morad M. Voltage- and receptor-gated Ca2+ channels. In: A Guidotti, ed., Neurotoxicity
of Excitatory Amino Acids, Raven Press, Ltd., New York, pp. 31-40, 1990. 21. Lacinova L, Hanbauer I, Sham JSK, and Morad M. Peptidergic regulation of Ca2+
channels. In: Peptide Regulation of Cardiovascular Function, Takeda Science Foundation, Japan, pp. 337-348, 1991.
22. Agus ZS, Kelepouris E, Dukes I, Kasama R, and Morad M. Magnesium as an intracellular
modulator of calcium, potassium and chloride channels. In: M Morad and Z Agus, eds., Intracellular Regulation of Ion Channels, NATO ASI Series, Vol. H 60, Springer-Verlag, Heidelberg, pp. 231-240, 1992.
23. Agus ZS, Kelepouris E, Dukes ID, Kasama R, and Morad M. Magnesium as an
intracellular modulator of calcium, potassium and chloride channels. NATO ASI Series H 60:232-239, 1992.
24. Morad M, and Sham Jsk. Ca2+ gating of Ca2+ release in heart muscle. In: D Ganten, F
Hofmann and G Mall, eds., Cellular Mechanism of Regulation of Heart and Circulation: Pharmacological and Clinical Consequences, Schattauer Verlag, Stuttgart, Germany, 1993.
25. Morad M. Signaling of Ca2+ release and contraction in cardiac myocytes. In: S Sideman
and R Beyar, eds., Molecular and Subcellular Cardiology: Effects of Structure and Function, Plenum Press, New York, New York, 1995.
26. Morad M, Shuba Ym, and Fan J. Temporal Modulation of the preferred Ca2+ influx
pathway. A novel effect of ß-agonists on the heart. In: Endoh, Morad, Scholz, Iijima, eds., Molecular and Cellular Mechanisms of Cardiovascular Regulation. Springer Verlag, Tokyo, 1996.
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27. Morad M. Signaling of calcium release in cardiac muscle. In: M Morad, S Ebashi, Y Kurachi, W Trautwein, eds., Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters. Kluwer, Dordrecht, 1996.
28. Cleemann L, Wei W, and Morad M. Rapid Confocal Measurements of Ca2+ sparks in rat
ventricular myocytes. In: J.R. Sotello and J.C. Benchi, eds., Ca2+ and cellular metabolism transport and regulation. Plenum Press, New York, New York, 1997.
29. Cleemann L, Dimassa G, and Morad M. Ca2+ sparks within 200 nm of the sarcolemma
of rat ventricular cells: Evidence form total internal reflection fluorescence microscopy. In: S. Siedman and R. Beyer, eds., Molecular and Subcellular Cardiology, Plenum Press, New York, New York, 1997.
30. Suzuki, YJ and Morad M. Ca2+ signaling in cardiac myocytes: Evidence from
evolutionary and transgenic models. In: S. Siedman and R. Beyer, eds., Molecular and Subcellular Cardiology, Plenum Press, New York, New York, 1997.
31. Cleemann, L., Fan, J., and Morad M. Control of secretion in chromaffin cells from
normal and spontaneously hypertensive rats. In: J. Nargeot and R. Tsien, eds., Low voltage activated T-type calcium channels. Adis International, Philadelphia, 1998.
Press, Amsterdam, Netherlands, 2001. 33. Woo s., Cleemann L., Morad M., Peripheral and Central Ca2+ Sparks in Atrial
Myocytes in Ca2+ – Signaling and Cross- talk in Excitable cell. Eds. M. Morad and P.G. Kostyuk, 2001.
34. Morad M, and Chau M. Learning about cardiac calcium signaling from genetic
engineering. In Cardiac Engineering: from genes and cells to structure and function, ed. Sideman S, Beyar R, pp. 1-15. Annals of the New York Academy of Science, New York, 2004.
35. Morad M, Javaheri A, Risius T & Belmonte S. Multimodality of Ca2+ Signaling in Rat
Atrial Myocytes. In The Communicative Cardiac Cell, ed. Sideman S, Beyar R & Landesberg A, pp. 112-121. Annals of the New York Academy of Sciences, New York, 2005
36. Morad, M., Soldatov, N. (2005) Calcium channel inactivation: possible role in signal transduction and Ca2+ signaling. Cell Calcium, 38(3-4), 223-31.
37. Janowski E, Cleemann L, Sasse P & Morad M. Diversity of Ca2+-signaling in
developing cardiac cells. In, ed. Sideman S, Beyar R & Landesberg A, pp. In press. Annals of the New York Academy of Sciences, New York, 2006.
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38. Progress in Biophysics and Molecular Biology. Editors Kohl, Christen, and Morad. Progress in Biophysics and Molecular Biology of the Beating Heart. Volume 110, Issues 2–3, Pages 151-153. doi: https://doi.org/10.1016/j.pbiomolbio.2012.08.007
39. Zhang, X.H., Martin Morad. (2016) Calcium signaling in human stem cell-derived cardiomyocytes: Evidence from normal subjects and CPVT afflicted patients. Cell Calcium, 59, 98-107.
40. Morad, M., Zhang, X.H. (2017) Mechanisms of spontaneous pacing: sinoatrial nodal cells, neonatal cardiomyocytes, and human stem cell derived cardiomyocuytes. Can J Physiol Pharmacol, 95(10), 1100-1107.
Abstracts 146 abstracts were published between 1966 and 1991. Only abstracts published since 1995 are listed below. 1. Adachi-Akahane S, Cleemann L, and Morad M. Cross-talk between Ca2+-release and
inactivation of L-type Ca2+ channel in rat ventricular myocytes. Biophys. J. 68:A355, 1995. 2. Ducic I, Neville RF, and Morad M. Modulation of K+ currents by antihistamines in rat
ventricular myocytes. Biophys. J. 68:A113, 1995. 3. Fan J, Shuba Y, and Morad M. Modulation of sodium-calcium exchanger by beta-
adrenergic agonists in frog ventricular myocytes. Biophys J. 68:A136, 1995. 4. Iwata T, Kraev A, Morad M, and Carafoli E. Cloning of the cDNA of the frog heart
sarcolemmal Na+-Ca exchanger. Biophys J. 68:A136, 1995. 5. Shuba YM, Naidenov VG, and Morad M. Analysis of Ca2+ current from rat cerebellum
expressed in Xenopus oocytes using a glass funnel technique. Biophys J. 68:A382, 1995. 6. Cleemann L, Fan J, Lara B, Gandia L, and Morad M. Excitation-secretion coupling in
cultured rat chromaffin cells is gated primarily by the L-type Ca2+ channel. Biophys J. 68:A234, 1995.
7. Adachi-Akahane S, Cleemann, L, and Morad M. Effect of BayK8644 on cross-signaling
between DHP- and ryanodine-receptors in rat ventricular myocytes. Biophys. J., 70(2):A245, 1996.
8. Adachi-Akahane S, Cleemann, L, Morad M, and Philipson K. Calcium signaling in
9. Adachi-Akahane S, Cleemann, L, and Morad M. Calcium release from the SR caused by spontaneous opening of the Ca2+ channel in rat ventricular myocytes. Biophys. J., 70(2):A274, 1996.
10. Suzuki YJ, Monterubio J, Cleemann L, Abernethy DR, Morad M. H2O2-stimulation of
Ca2+-signaling in intact cardiac myocytes. Biophys. J., 70(2):A270. 11. Fan J, Cleemann L, and Morad M. Ca2+ influx via Ca2+ channels, not cytosolic Ca2+
activity, directly controls adrenergic secretion in rat chromaffin cells. Biophys. J., 70(2):A294, 1996.
12. Cleemann L, Dimassa G, and Morad M. Distributions of “Ca2+ sparks” in rat ventricular
cardiomyocytes recorded with rapid confocal microscopy. Biophys. J., 70(2):A273, 1996.
13. Ko Cm, Maccormack M, and Morad M. A novel Cd2+-insensitive Ca2+ channel in
cardiac myocytes. Biophys. J., 70(2):A324, 1996. 14. Shuba Ym, Naidenov Vg, and Morad M. Cardiac Ca2+ channels expressed in Xenopus
oocytes are not susceptible to phosphorylation/dephosphorylation. Biophys. J., 70(2):A323, 1996.
15. Ducic I, Ko CM, and Morad M. Modulation of K+ currents by nonsedating H1-
antagonists in rat ventricular myocytes. FASEB, 10(3):A316, 1996. 16. Ko Cm, Fan J, Maccormack M, Cleemann L, and Morad M. Modulation of K+ currents
by nonsedating H1-antagonist, ebastine, in guinea-pig ventricular myocytes. FASEB, 10(3):A316, 1996.
17. Drici MD, Ducic I, Morad M, and Woosley R. Inward rectifier K+ current (IKr) and
transient outward current (Ito) have lower expression in female rabbits. FASEB, 10(3):A428, 1996.
18. Wang W, Suzuki YJ, Cleemann L, Jones LR, and Morad M. Ca2+ sparks and Ca2+ release
in transgenic myocytes overexpressing cardiac calsequestrin. Biophys. J., 72:A44, 1997. 19. Dimassa G, Wang W, Cleemann L, and Morad M. Calcium sparks in rodent
cardiomyocytes are modulated by holding potential and Ca2+ buffers. Biophys. J., 72:A44, 1997.
20. Cleemann L, and Morad M. Visualization of calcium sparks in heart cells with total
internal reflection fluorescence microscopy (TIRF). Biophys. J., 72:A45, 1997. 21. Drici MD, Shuba YM, Oz M, and Morad, M. Role of the external Ca2+ in the modulation
of IKr current. Biophys. J., 72:A50, 1997.
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22. Shuba YM, Naidenov VG, Sandberg K, and Morad M. Functional expression of the amphibian cardiac Na+-Ca2+ exchanger. Biophys. J., 72:A110, 1997.
23. Suzuki YJ, Philipson KD, and Morad M. Ca2+ signaling in transgenic mice
overexpressing mutant cardiac Na+-Ca2+ exchanger. Biophys. J., 72:A162, 1997. 24. Suzuki YJ, Cleemann L, and Morad M. Glutathione is a co-factor for H2O2-mediated
stimulation of Ca2+-induced Ca2+ release in cardiac myocytes. Biophys. J., 72:A165, 1997. 25. Suzuki Yj, Kobayashi M, Morad M, and Jones Lr. Excitation-contraction coupling in
transgenic myocytes overexpressing cardiac calsequestrin. Biophys. J., 72:A234, 1997. 26. Cleemann L, Wang W, and Morad M. Activation of Ca2+ buffered heart cells by strings of
Ca2+ sparks. Biophys. J., 72:A343, 1997. 27. Cleemann L, and Morad M. Nitric Oxide suppresses catecholamine secretion in cultured
chromaffin cells from spontaneously hypertensive rats. Biophys. J., 72:A366, 1997. 28. Zhang J, Suzuki Yj, Jones Lr, and Morad M. Overexpression of cardiac calsequestrin in
transgenic myocytes alters the cAMP sensitivity of Ca2+ current. Biophys. J., 72:A371, 1997.
29. Knollmann BC, Maccormack, and Morad M. Recovery of inactivated sodium and calcium
channels by strong depolarization in rat ventricular myocytes- an example for gating mode shifts in whole cell recordings. Biophys. J., 72:372, 1997.
30. Zhang JX, Kellar KJ, and Morad M. Electrophysiological properties of nicotinic current in stably transfected HEK293 cell line expressing α3β4 receptors. Society for Neurosci. 23:385, 1997. 31. Cleemann L, Clutton P, Mccormick M, and Morad M. Total internal fluorescence
microscopy shows Ca2+ sparks in cardiomyocytes from Rattus norvegicus but not from Squalus acanthias. MDIBL Bulletin 36: 38-40, 1997.
32. Clutton P, Cleemann L, and Morad M. Preparation of ventricular cardiomyocytes from
Squalus acanthias. MDIBL Bulletin 36:41-42, 1997. 33. Soldatov NM, Oz M, O'brien KA, Abernethy DR, and Morad M. Molecular determinants
of L-Type Ca2+ channel inactivation identified by segment exchange analysis of the cytoplasmic motif encoded by Exons 40-42 of the human α1C subunit gene. Biophys. J. 74(A), M-337, 1998.
34. Cleemann L, Wei W, and Morad M. Organization, density and unitary properties of
cardiac Ca2+ release sites in rat ventricular myocytes. Biophys. J. 74(A), W-L10, 1998.
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35. Oz M, O'brien K, Soldatov N, and Morad M. cAMP-Sensitivity Conferred Upon Mammalian Cardiac Na+-Ca2+ Exchanger by a Segment of the Amphibian Na+-Ca2+ Exchanger. Biophys. J. 74(A), W-71, 1998
36. Oz M, Soldatov N, Melia M, Sandberg K Abernethy D, and Morad M. Inhibition of
Recombinant Human L-Type Ca2+ Channel by the Activation of Angiotensin AT1A Receptors Co-Expressed in Xenopus Oocytes. Biophys. J. 74(A), Th-192, 1998.
37. Knollmann B, Jones L, and Morad M. Electrophysiologic Properties of Transgenic
Myocytes Overexpressing Cardiac Calsequestrin. Circulation 71: A-970, 1998. 38. Knollmann B, Duc J, Groth A, Weissmann N, Cleemann L, and Morad M. Cardiac
Phenotype of Transgenic Mice Overexpressing Calsequestrin. Circulation 71: A-2580, 1998.
39. Knollmann B, Trivedi K, Weissmann N, and Morad M. Transgenic mice with
cardiomyopathy - an Attractive Model for Drug Development? Clinical Pharm & Ther. 65: (2) OIII-A-1, 1999
40. Cleemann L, Wang W, and Morad M. Colocalization of Ca2+ Release Sites and t-Tubular
Membrane in Rat Ventricular Cardiomyocytes. Biophys J. 76: Tu-521, 1999. 41. Cleemann L, Wang W, and Morad M. Dual Modulation of Unitary Ca2+ Release in Rat
Ventricular Cells. Biophys. J. 76: Tu-523, 1999. 42. Melia M, Karginova E, Abernethy D, Soldatov N and Morad M. Stimuli- and Age-
dependent Expression of Ca2+ Channel ∀1C Subunit Splice Variant with Exon 21 Contributing to Lower Dihydropyridine Sensitivity. Biophys. J. 76: W-H5, 1999.
43. Wang W and Morad M. Caffeine Restores Ca2+ Signaling and Spark Formation in
Transgenic Myocytes Over-Expressing Calsequestrin. Biophys. J. 76: W-368, 1999. 44. Xu L, Meissner G, Vang J, Abernethy D, Soldatov N and Morad M. The Carboxyl-
45. Zhenochin S, Vang J, Albanna B, Park D, Abernethy D, Soldatov N and Morad M.
Naturally occurring single amino acid mutation that alters inactivation kinetics and ion selectivity of the human ∀1C Ca2+ channel. FASEB Journal 13: (4) 106.11, 1999.
46. Knollmann B, Knollmann B, Weissman N, Jones L and Morad M. Electrophysiological
Remodeling in Hypertrophic and Failing Hearts of Calsequestrin Overexpressing Mice. American Heart Assoc. 72nd Scientific Sessions: vol. 100, no. 18, I-425, 1999.
47. Gupta T, Dorfman J, Cleeman L, and Morad M. Amiloride: A novel neuronal nicotinic
acetylcholine receptor (nAChR) blocker. Society for Neuroscience. 25: 497.5, 1999.
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48. Woo S, Cleemann L, Dorfman A, and Morad M. Modulation of Na+/Ca2+ Exchanger by ß-
Adrenergic Stimulation in Shark Ventricular Myocytes. Biophys. J. 78: Tu-2195, 2000. 49. He L, Soldatov N, Cleemann L and Morad M. Molecular Determinants of cAMP
Regulation of Recombinant Na+/Ca2+ Exchanger. Biophys. J. 78: Tu-2201, 2000. 50. Knollmann B, Weissman N, Broth A, De Freitas F, Potter J and Morad M. Cardiac
Phenotype of Transgenic Mice Overexpressing Human Cardiac Troponin T with an ILE79ASN Mutation. Biophys. J. 78: W-2564, 2000.
51. Kurokawa J, Soldatov N, Adachi-Akahane S, Cleemann L and Morad M. Regulation of
Ca2+ Sparks by Carboxy-Terminal Tail of Cardiac Ca2+ Channel. Biophys. J. 78: M-874, 2000.
52. Knollmann B, Groth A, Akguc M, and Morad M. Pisitive inotropic and lusitropic effects
of the K+-channel inhibitor Betrosamil? Clinical Pharmacology and Therapeutics, 67(2): 117, 2000.
53. Silva P, Solomon R, Morad M, and Epstein F. H. Tedisamil inhibits chloride Secretion by
the rectal gland of Squalus acanthias, M.D.I.B.L Bulettin 39:69, 2000. 54. N’ Gouemo P, and Morad M. Alcohol withdrawal induces enhanced calcium channel
activity in rat inferior colliculus neurons. Abs Soc Neuroscience 26: 1820, 2000. 55. Knollmann BC, Stepehn A, Fatima DE Freitas B, Miller T, Apstein CS, Housmans PR,
Weissman N, Morad M, Potter JD. Cardiac performance depdends on inortopic state of mice expressing and FHC- linked troponin T mutation, Biophys J., 0:104a, 2000.
56. Woo S-H, Cleemann L, and Morad M. Characteristics of focal Ca2+ release sites in rat atrial
myocytes. Biophys J., 0: 64a, 2001. 57. Abdrakhmanova G, Dorfman J, Xiao J, Morad M. [H+]o Accelerates signaling in A3/B4
neuronal Nachrs stably transfected in HEK 293 cells, Biophys J., 80: 104a, 2001. 58. Knollmann BJ, Greene AE, Franz MR, Potter JD, and Morad M. Abnormal cardiac
electrophysiology in transgenic mice expressing an FHC-linked troponin T(179N) mutation, Biophys J., 80: 189a, 2001.
59. Woo S-H, Cleemann L, and Morad M. Gating mechanisms of Ca2+ release in rat atrial
myocytes, Biophys J., 80: 507a, 2001. 60. N’gouemo P, Yasuda R. and Morad M. Upregulation of voltage-gated Ca2+ channel and
downregulation of Ca2+-activated K+ channels protein in rat inferior colliculus associated with ethanol withdrawal. Soc. Neuroscience Abstr. 27:918.16, 2001.
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61. Abdrakhmanova G, Cleemann L, Lindstrom J, Morad M. pH Effect on Gating of Different Subtypes of Human Neuronal Nicotinic Receptors. Biophys. J. 82: 215a, 2002.
62. Cleemann L, Degitar V, and Morad M. TIRF Imaging of Focal Ca2+ Release in Voltage-
Clamped Atrial and Ventricle Myocytes. Biophys. J. 82:282a., 2002. 63. Degitar V, and Morad M. Modulation of Cardiac Ca2+ Channel Current by Extracellular
Na+. Biophys. J. 82:574a, 2002. 64. Sasse P, Cleemann L, Fleischmann BK, Hescheler J, and Morad M. Subcellular
Localisation of Intracellular Calcium Stores in Embryonic Cardiomyocytes. Biophys. J. 82:652a, 2002.
65. Knollmann, BC, Schober T., Mackow J., Chau M., Potter J. D., Morad M. Ca2+
Signaling in Transgenic Myocytes Expressing a FHC-Linked Troponin T (179N) Mutation. Biophys. J. 82:57a, 2002.
66. Woo S.H., Soldatov N., Morad M. Modulation of Spontaneous Sparks By Fragments of
C-Terminal Tail of Cardiac Ca2+ Channels. Biophys. J. 82:281a, 2002. 67. Woo S. H., Cleemann L., Morad M. Comparison of Central and Peripheral Ca2+
Releases in Voltage-Clamped Atrial Myocytes. Biophys. J. 82:282a, 2002. 68. N’Gouemo, P. and Morad, M. Phosphorylation of calcium channel modulated the
increased current density in rat inferior colliculus neurons following ethanol withdrawal. Abs. Soc. Neurosci. 25: Program #602.3, 2002.
69. Knollmann, B.C., Kirchhof, P., Sirenko, S.G., Potter, J.D., and Morad, M. The FHC-
Linked Troponin T (I79N) Mutation Causes Ventricular Arrhythmias And Altered Intracellular Ca2+ Handling In Transgenic Mice. (Melvin Marcus Young Investigator Award Finalist.) Circulation 105: Supplement II. 2002.
70. Degtiar, V., Cleemann, L., and Morad, M. High resolution imaging of Ca2+ sparks,
quarks, and single channel fluxes in rat cardiac myocytes. Biophys. J. 84:9a, 2003. 71. Woo, S.H., Cleemann, L., and Morad, M. Spatio-temporal characteristics of junctional
and non-junctional Ca2+ sparks in rat atrial myocytes. Biophys. J. 84:201a, 2003. 72. Cleemann, L., Degtiar, V., and Morad, M. TIRF imaging with 1.4 ms time resolution of
subsarcolemmal Ca2+ signals in cardiac myocytes. Biophys. J. 84:201a, 2003. 73. Abdrakhmanova, G., Cleemann, L., Lindstrom, J.M., and Morad, M. Rapid co-
application of H+ and ACh differentially modulates human neuronal aAChRs. Biophys. J. 84:228a, 2003.
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74. N’Gouemo, P., Yasuda, R.P., Morad, M., and Faingold, C.L. Audiogenic seizure alters the expression of calcium and potassium channel proteins in inferior colliculus neurons of the genetically epilepsy-prone rat (GEPR-3). Abstract Viewer/Planner, Program 212.20, Washington. DC: Society for Neuroscience, 2003. Online.
75. N’Gouemo, P., Morad, M., and Faingold, C.L. Upregulation of calcium channel current
is associated with seizure susceptibility in the genetically epilepsy-prone rat (GEPR-3) in inferior colliculus neurons. Abstract Viewer/Planner, Program 566.4, Washington. DC: Society for Neuroscience, 2004. Online.
76. Janowski, E., Cleemann, L. and Morad, M. (2005). Proton-activated calcium release
stores in human breast cancer cell lines. Biophysical Journal 88, 439a. 77. Lee, S.-Y., Lee, C. O., Morad, M. and Woo, S.-H. (2005). Modulation of atrial
78. Belmonte, S. and Morad, M. (2005). Probing the signaling cascade mediating puff-
triggered Ca2+ transients in rat atrial myocytes. Biophysical Journal 88, 23a. 79. N’Gouemo, P., and Morad, M. Ethanol withdrawal is associated with downregulation of
Ca2+-activated K+ channel current in rat inferior colliculus neurons. Abstract Viewer/Planner, Program 110.8, Washington. DC: Society for Neuroscience, 2005. Online.
80. N’Gouemo, P., and Morad, M., Alcohol withdrawal enhances intracellular Ca2+ release
in rat inferior colliculus neurons. Abstract Viewer/Planner, Program 193.13, Washington. DC: Society for Neuroscience, 2006. Online.
81. Dietrich, C.J., Shuba, Y., Cleemann, L., and Morad, M. Does proton release accompany
vesicular exocytosis? Abstract Viewer/Planner, Program 730.17, Washington. DC: Society for Neuroscience, 2006. Online.
82. Janowski, E., Cleemann, L. and Morad, M. Proton-activated calcium release stores in
human breast cancer cell lines. Biophysical Journal 88, 439a, 2005. 83. Lee, S.-Y., Lee, C. O., Morad, M. and Woo, S.-H. Modulation of atrial excitation
contraction coupling by flow-mediated shear stress. Biophysical Journal 88, 139a., 2005 84. Belmonte, S. and Morad, M. Probing the signaling cascade mediating puff-triggered
Ca2+ transients in rat atrial myocytes. Biophysical Journal 88, 23a. 2005. 85. Belmonte S and Morad M. Assessing the mitochondrial regulation of puff-triggered
Ca2+-transients in rat atrial myocytes. Biophysical Journal 2006_Abstracts, 521a, 2006.
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86. Day RM, Janowski E, Movafagh S, Heyrana K, Lee J, Kraev A, Roder JD, Towle DW, Cleemann L, and Morad M. Cloning and expression of the cardiac Na-Ca exchanger. Biophysical Journal 2006_Abstracts, 511a.
87. Janowski E, Cleemann L, and Morad M. Multiplicity of calcium pools in rat neonatal
cardiomyocytes. Biophysical Journal 2006_Abstracts, 521. 88. Janowski E, Isakova A, Berrios M, and Morad M. Calcium signaling characterization of
P19 pluripotent stem cells differentiated into neuronal and cardiac cell types. Biophysical Journal 2006_Abstracts, 524a.
89. Woo S-H, Thu LT, and Morad M. Regulation of Ca2+ current-triggered Ca2+ propagation
in rat atrial myocytes: role of mitochondria. Biophysical Journal 2006_Abstracts, 220a. 90. Janowski, E & Morad, M. (2007), IP3 and RyR Calcium Signaling in Rat Embryonic
and Neonatal Cardiomyocytes. Biophysical Journal, 2007 Abstract Issue. 91. Janowski, E, Cleemann, L, Day, R.M. & Morad. M. (2007). Structure and Function of
97. Movafagh, S., Morad, M. (2008). Does Na+ preserve the cardiac Ca2+ channel
conductance during hypoxia? Biophysical Journal, 2008 Abstract Issue. 98. Movafagh, S., Morad, M. (2009). L-type Ca channel as an oxygen sensor; possible
involvement of Ca/calmodulin binding domain. Biophysical Journal, 2009 Abstract Issue.
99. Dietrich, C.J. & Morad, M (2009). Endogenous acidification of central inhibitory
100. Einsley Janowski, Regina Day, Alexander Kraev, Lars Cleemann, and Martin Morad
(2009). β-adrenergic regulation of a novel isoform of NCX: Sequence and expression of shark heart NCX in human kidney cells. Biophysical Journal, 2009 Abstract Issue.
101. Lars Cleemann, Sarah Haviland, Ronnie Dalsgaard, and Martin Morad (2009). The
persistently beating hagfish heart. Biophysical Journal, 2009 Abstract Issue. 102. Mei Ding, Lars Cleemann, & Martin Morad (2009). Regulation of swelling-activated
Cl- channel in HEK cells by extracellular low pH. Biophysical Journal, 2009 Abstract Issue.
103. Brooke Damon, Lars Cleemann, and Martin Morad (2010). Pressure puff induced
calcium signals in voltage-clamped cardiomyocytes. Biophysical Journal, 2010 Abstract Issue.
104. Sarah Haviland, Lars Cleemann, Tim McQuinn, Michael Kern, and Martin Morad
(2010). Expression and regulation of shark NCX gene in transgenic mouse heart. Biophysical Journal, 2010 Abstract Issue.
105. Angelo O. Rosa, Lars Cleemann, Martin Morad (2010). Oxygen sensing of L-type
calcium channels in rat cardiomyocytes: The possible role of hemoxygenase. Biophysical Journal, 2010 Abstract Issue.
106. Hale Tufan, Lars Cleemann, Mark Sussman, and Martin Morad (2010). Ca2+ transients
in PIM-1 transfected cardiac stem cells co-cultured with rat neonatal cardiomyocytes. Biophysical Journal, 2010 Abstract Issue.
107. Arnaiz-Cot JJ, Damon B, Haviland S, Kettlewell S, Cleemann L, and Morad M (2011)
Regional Specialization of Mitochondrial Ca2+ Signaling in Cardiac Cells. Biophys J, 2011. 100: p. 44a.
108. Rosa, A.O., N. Yamaguchi, and M. Morad (2011) Mechanical Induced Inhibition of L-
Type Calcium Channels Biophys J, 2011. 100: p. 570a. 109. Arnaiz-Cot, JJ, Stone SL, Meissner G, Yamaguchi N, and Morad M (2011) Calcium
Signaling in Mouse Ventricular Myocytes with Impaired Calmodulin Regulation of RyR2 Biophys J, 2011. 100: p. 85a.
110. Brooke J. Damon, Juan Jose Arnaiz-Cot, Susannah L. Stone, Lars Cleemann, Naohiro
Yamaguchi, Martin Morad (2012) Arrhythmogenic NCX currents in casrdiomyocytes from transgenic mice expressing mutated RyR2 receptors. Biophysical Journal, 2012 Abstract Issue. 1567-Pos
111. Juan Jose Arnaiz-Cot, Azra Fatima, Susannah L. Stone, Lars Cleemann, Jürgen
Hescheler, Tomo Saric, Martin Morad (2012) Ca signaling in cardiomyocytes from
112. Hale Tufan, Xiaohua Zhang, Nicole Haghshenas, Mark A. Sussmann, Martin Morad
(2012) Ca2+-signaling in cardiac progenitor cells engineered with PIM-1 and their electrophysiological coupling to co-cultured neonatal rat cardiomyocytes. Biophysical Journal, 2012 Abstract Issue Pos-L134.
113. Xiao-Hua Zhang, Susannah L. Stone, Azra Fatima, Jürgen Hescheler, Tomo Saric,
Martin Morad (2012) Spontaneous Ca2+ oscillations in beating human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and rat neonatal cardiomyocytes (RN-CM). Biophysical Journal, 2012 Abstract Issue Pos-L134.
114. John Arthur Scarigi, Angelo Oscar Rosa, Lars Cleemann, and Martin Morad (2013). -
The cardiac Ca channel is suppressed by hypxia in 1 sec. 2013 Abstract Issue Pos-2353. 115. Zhang, X-H., Haviland, S., Wei, H., Saric, T., Hescheler, J., Cleemann, L., Morad, M.
(2013). Ca2+ Signaling profiles of control and CPVT-expressing human iPSCs-derived cardiomyocytes. Biophysical Journal, 2013 Abstract Issue Pos-1520.
116. Haviland, S., Kettlewell, S., Smith, G., Cleemann, L., Morad, M. (2013). A new
approach to evaluation of mitochondrial Ca-signaling in cardiomyocytes. Biophysical Journal, 2013 Abstract Issue Pos-3169.
117. Xiao-Hua Zhang, Lars Cleemann, Martin Morad (2014). Fluorescence Signal Kinetics
of a New Ca2+ Probebound to Cardiac Ryanodine Receptors Point to Micro-Domain Detection of Ca2+. Biophysical Journal, Vol. 106, Issue 2, p114a.
118. Sara Pahlavan, Yuming Yang, Caitlin Robertson, Naohiro Yamaguchi, Lars Cleemann,
Martin Morad (2014) A New Ca2+ Probe, Calstabi-Cam, Targeted to Ryanodine Receptors of Cardiomyocytes. Biophysical Journal, Vol. 106, Issue 2, p242a
119. Xiaohua Zhang, Naohiro Yamaguchi, Lars Cleemann, Martin Morad (2015) Diversity
of mitochondrial Ca2+ signaling: Evidence from genetically encoded probes. Biophysical Journal. Vol. 108, Issue 2, p109a. doi:10.1016/j.bpj.2014.11.616
120. John A. Scaringi, Nordine Helassa, Katalin Torok, Martin Morad (2015) GCAMP3-
derived genetically engineered as rapid intracellular signals for calcium dynamics. Biophysical Journal, Vol. 108, issue 2, p150a. doi:10.1016/j.bpj.2014.11.828
121. Jose C. Fernandez-Morales, Xiao-Hua Zhang, Hua Wei, Lars Cleemann, Martin Morad (2015). Regulation of ICa during Simulated Acute Ischemia in Developing Cardiomyocytes Exposed to Hypoxia and Low pH. Biophysical Journal. Vol. 108, issue 2, p272a. doi:10.1016/j.bpj.2014.11.1492
122. Jose C. Fernandez-Morales, Xiao-Hua Zhang, Hua Wei, Lars Cleemann, Martin Morad (2015). Regulation of ICa during Simulated Acute Ischemia in Developing Cardiomyocytes Exposed to Hypoxia and Low pH. Biophysical Journal. Vol. 108, issue 2, p272a.
123. Zhang XH, Naohiro Yamaguchi, Lars Cleemann, Martin Morad. Diversity of mitochondrial Ca2+ signaling: evidence from genetically encoded probes. Biophysical Journal, 2015 Abstract Issue Volume 108, Issue 2, Supplement 1, p109a. Biophysical society 59th annual meeting.
124. Jose C. Fernadez-Morales, Xiao-hua Zhang, Hua Wei, Lars Cleeman, Martin Morad. Regulation of ICa during simulated acute ischemia in developing cardiomyocytes exposed to hypoxia and low pH. Biophysical Journal, 2015 Abstract Issue, Volume 108, Issue 2, Supplement 1, p272a. Biophysical society 59th annual meeting.
125. Zhang XH, Couch C, Torok K and Morad M. New targeted Ca2+ probes reveal mitochondrial Ca2+ signaling plays a critical role in rat sino-atrial (SA) nodal pacing. Biophysical society 60th annual meeting, Los Angeles, Feb 27-Mar 2, 2016.
126. Fernandez-Morales, Zhang, XH, Cleeman, L., Morad, M. Suppression of cardiac ICA and Ca2+ releaseby acute hypoxia and acidification. Biophysical Society 60th annual meeting. Feb 27-March 2, 2016.
127. Zhang XH, Yamaguchi N, Cleemann L and Morad M. Preveleged Ca2+ signaling pathway between membrane NCX and mitochondria in cardiac myocytes. Biophysical society 60th annual meeting, Los Angeles, Feb 27-Mar 2, 2016.
128. Zhang XH, Wei Hua, Naohiro Yamaguchi, and Martin Morad. CRISPR/CAS9 created CPVT1 associated RyR2 mutations reliably reproduces the calcium signaling aberrancy in human IPSC-CMS. Biophysical society 62th annual meeting, San Francisco, Feb 17-21, 2018.
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Major National and International Lectures by Invitation; 2017: 1. “Can gene editing provide mechanistic insights into congenital arrhythmias?” 13th Annual
CDBC/COBRE Symposium on Cardiovascular Development, Charleston, SC, August 5-7.
2. “Role of pacemaking of rat SA-nodal cells and human iPSC derived cardiomyocytes: functional insulator vs. primary oscillator, European Section Meeting of IACS, Pecs, Hungary, September 28-30.
3. “Insights into CPVT1 arrhythmia from genetic editing of cardiac ryanodine receptor”, Seged, Hungary, October 1.
4. “CRISPR/Cas9 gene editing of cardiac ryanodine receptor: insights into CPVT1 arrhythmia, October 4, University of Paris SUD, Paris, France.
5. “Insights into CPVT1 arrhythmia from genetic editing of cardiac ryanodine receptor,” October 6, Pierre and Marie Currie Hospital, Paris, France.
2016 1. “Role of If in pacemaking of rat SA-nodal cells and human iPSC-derived Pacemaker
mechanisms in human ipsc-derived cardiomyocytes: A step closer to tissue-based pacemakers. Sherbrooke, Canada, September 22-24
2. Pacemaker Mechanism in human ipsc-derived cardiomyocytes, a step closer to biological pacemaker. Max Delbruck Center, Berlin Germany, April ,22.
3. “Mechanisms underlying initiation of spontaneous beating in the heart: Facts, Fantasies & a role for mitochondria?” UCLA, Los Angeles California, April.
2015: 1. “Mechanism of cardiac pacemaking,” Erlangen, Germany Department of Biochemistry, April
13.
2. “Using non-viral gene delivery by sleeping beauty to generate hHCN4-expressing hiPSCs as a platform for pacemaker cardiomyocytes differentiation”, with Angelica Garcia-Perez of the Max Delbruck Center for Molecular Medicine, Regenerative Medicine Workshop, Hilton Head, SC, USA. May 15.
3. “Xanthohumol modulates calcium signaling in rat ventricular myocytes: possible arrhythmic properties, Regansburg University, Germany, September 24.
2014: 1. “Insights into arrhythmia and heart failure from studies on human stem cell-derived
cardiomyocytes and mouse genetics”, Philadelphia University, Jordan, Amman. January 28.
2. “Mechanism of spontaneous rhythmic beating in developing cardiomyocytes”, International Academy of Cardiovascular Science Symposium, Delhi, India. February 1.
3. “Probing the nano-domains of Cardiac Ca2+-signaling with genetically targeted biosensors”, University of Jammu, Kashmir. February 14.
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4. “Mechanisms of spontaneous rhythmic beating in developing cardiomyocytes”, Annual Cardiovascular Developmental Biology center Symposium, Charleston, SC, USA. March 20.
5. “Cardiac ryanodine receptor point mutations causing CPVT and Heart Failure: Evidence from human iPSC-derived cardiomyocytes and transgenic mice”, Mt. Sinai Department of Cardiology, New York, NY, USA. June 2.
6. “Probing the nano-domains of cardiac Ca2+-signaling proteins by smart biosensors”, Charleston workshop on light microscopy for biosciences, Charleston, SC, USA. June 18.
7. “Probing the nano-domains of Cardiac Ca2+-signaling with genetically targeted biosensors”, International Academy of Cardiovascular Sciences, Winnipeg, CA. September 5.
8. “Ca2+-signaling as a mechanism of spontaneous pacing in human iPSC derived cardiomyocytes”, Max Delbruck Center for Molecular Medicine, Berlin, Germany. September 26.
9. “Ca2+ metabolism and heart failure”, International Heart Failure Symposium, Berlin, Germany. September 27.
10. “Mechanisms underlying initiation of spontaneous beating in developing heart: Facts, Fantasies & a role for mitochondria?”, Imperial College of London, London, UK. September 30.
11. “Probing the nano-domains of Cardiac Ca2+-signaling by genetically engineered smart biosensors”, St. George’s, University of London, Tooting, UK. October 1.
2013:
- “Calcium signaling in human induced pluripotent cells”, Institute of Neurophysiology, University of Cologne, Germany. February 11.
- “Biological Pacemakers: How close are we”? Max Delbruck Institute, Berlin Germany.
- “Calcium signaling in human derived Stem Cells” Charity Hospital, Cardiovascular research Center, Berlin, Germany. February 18.
- Bio Health 2013, representing USC, Chicago, IL. April 21-25.
- Scientific Advisory Board of Mechano-electrical coupling & Arrhythmias meeting, Oxford, UN. September 12-15.
- From Neuromuscular Junctions to Bats and beyond Symposium, UCLA, California. November 7-8.
2012:
- “Calcium Signaling in human IPSCs: How close are we to mature heart?” 10th Annual CDBC Spring Symposium. Sponsored by Department of Regenerative Medicine and Cell Biology, MUSC, Charleston, SC, USA.
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- “Community talk” at Yeamans Hall Club, On Biological Pacemakers Charleston South Carolina, USA.
- Department of Cardiology, University of Munich, Munich, Germany “Calcium Signaling In human derived pluripotent cells.”
- Symposium on Regenerative Medicine, University of California at San Diego, San Diego, California, USA. Calcium signaling in human IPSCs: from Normal and CPVT-afflicted subjects.
- Department of Cardiology, University of C alifornia Los Angeles, California, USA. Biological Pacemakers: IPSC vs. Neonatal myocytes.
- “Community Talk: “How did I get here” at Balsam Mountain Preserve, Asheville, North Carolina, USA
- Seminar at MUSC, Mitochondrial working group. School of Pharmacy.
2011:
- CDBC Symposium in Charleston. Speaker and Chair. February 15-17.
- UCLA symposium. Invited speaker. February 25.
- Yemen’s Hall presentation. March 11.
- Seminar at Georgetown University. Washington DC. Sarah Haviland committee meeting. March 23-24.
- “Maturation of calcium handling in cardiomyocytes during development”. Conference: Cologne Conference on Cardiac Regeneration and Cell Therapy, Symposium of the BMBF-Consortium “Stem Cell Therapy of the Heart” Cologne, Germany. May 13-14.
- Texas Meeting, President's Initiatives Committee (PIC). August 29.
- ISHR European Section in Haifa, Israel. Title: “Calcium signaling and arrhythmogenic currents in cardiomyocytes with impaired calmodulin regulation of RyR2.” June 26-29.
- “Intracellular calcium oscillations initiate and modulate spontaneous pacing in human IPSC-derived myocytes”. Symposium: “Frontiers In Cardiovascular Regeneration”, Medical University of South Carolina, Charleston, SC, USA (Co Chair). November 17-18.
2010
- University of cologne. Seminar: “Ca2+ signaling in neonatal adult myocytes”. January 15.
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- Symposium and workshop on Ca2+ Signaling and EC coupling. UC Davis, California. February 25.
- Seminar at UCLA (Talk and discussion of collaboration). March 5-9.
- Annual Review of Medicine Meeting, Charleston South Carolina. April 1.
- COBC Symposium in Charleston. Cession Chair and discussion leader. April 13-15.
- University of Cologne. Seminar and discussion of collaboration. May 10.
- NCX symposium, Ischia Italy. Invited speaker: “Bimodal regulation of NCX in the heart”. October 1-4.
- Turkish Pharmacological Society Meeting, Ankara, Turkey, Invited Key note speaker: “Ca signalling in the heart”. Established communication with Pharmacology and Stem Cell Center in Ankara. October 18-26.
2009 - UCLA symposium. Lecture on “O2 sensing in the heart.” February 5-7.
- Seminar at Clemson University: “Cardiac pacemakers.” February 12-13.
- Talk at symposium organized by Richard Swaja at the Smart State Conference. April 14-15.
- Seminar in ICAN Institute of Cardiometabolism & Nutrition, INSERM/UPMC, Faculte de Medecine Pitie-Salpetriere, Paris France. May 1-6.
- IUPS Symposium, Kyoto, Japan. Talk: ”Oxygen-sensing in the heart”. (File, 8/31/2009). August 3.
- Bogomolite National Medical Institute, Kiev Ukraine. Talk: ”Synaptic transmission and the role of protons”. October10-14.
- Chicago. Talk the Racket Club members on “Biological pacemakers”. (8/27/2009“Biogenic Pacemakers” File). October 23.
- Council of Endowed Smart State chairs. October 29.
2008 - “Scientific Collaboration in South Carolina: A Path to Leadership”. Presentation at
University of South Carolina, Columbia SC. September 1.
- 6th Cardiac Workshop on Analysis of Cardiac Development from Embryo to Old Age”. Talk: “Anti-aging interference agents”, Technion, Haifa, Israel. March 30-April 1.
- Gordon Conference on Regulatory Mechanisms, chair and discussion. July 20-26.
- International Union of Physiological Sciences. Meeting in Kyoto. Talk: “O2 sensing in the heart”. Chair and discussion. July 27-31.
- Mount Desert Island Biological Laboratory, Maine: Stem Cell Symposium. August 9-11.
- Monday morning seminar series at Mount desert island biological Laboratory. “Role of NCX in cardiac Ca2+ gene in cardiac Ca2+ metabolism.” August 18.
- Neuroscience meeting, Washington DC. November 13-15.
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2004 - “Multiplicity of Cardiac Calcium signaling in rat atrial myocytes”. Invited lecture Loyola
Med. Center, Chicago, Ill. March, 24.
- “A novel shear-stress activated calcium signaling pathway in atrial myocytes”. UIC, Dept. of physiology. March 23.
- “Regulation of naked and coupled cardiac Ryanodine receptors” Gordon Research Conference on Cardiac regulatory Mechanisms. June6-11, Colby-Sawyer College, NH.
- “Plasticity of Calcium signaling in Atrium”, Oscillations and Waves in cells and cell networks, May10-14, 2004 Carsege, Corsica, France.
- “Mechano-electrical signaling in atrium”, IBRO workshop on Cell signaling, September 15-18, Yalta, Ukrain.
2003 - “Learning about cardiac calcium signaling from genetic engineering”. Erice Italy, 3rd Larry
Fairburg workshop, May18-24.
2002 - “What are we learning about cardiac Ca signaling from genetic engineering”. University of
Munich, October 2002.
- Key note talk on Ca2+ Signaling at the Physiological Society, Shiraz, Iran, March 2002
- International Society of Pathophysiology, International Congress, June 2002, symposium speaker, Budapest, Hungary.
2001 - 4th International Conference on Na+/Ca2+ Exchange. “Bimodal cAMP-mediated regulation of
Na+/Ca2+ exchanger in heart.” Banff, Canada. October 10-14, 2001.
- Columbia University, NYC, NY, Department of Pharmacology, Ca2+ Signaling, Sept. 24.
- ISHR International Congress, symposium speaker, Winnepeg, Manitoba, Canada, July 6-11.
- UNC, Chapell Hill, NC Seminar, Department of Biochemistry, Ion Channel remodeling in heart failure, March 7.
- UVA, Charlottesville, VA, Department of Physiology, Ion Channel remodeling in heart failure, March 2.
- Key note speaker, Ion Channel remodeling in cardiac hypertrophy and failure, Coronary Society, Sendai, Japan, Feb.2.
- Seminar speaker, Ion Channel remodeling in cardiac hypertrophy and failure, Dept. of Pharmacology, University of Tokyo, Japan, Feb 5.
2000 - Hypertension Workshop. “Regulation of Ca2+ channel in cardiac muscle.” Amilia Island,
Florida. January 11-14, 2000.
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- Park City Myocyte Conference. “Dual mode of regulation of Ca2+ spark formation in atrial myocytes.” Park City, Utah. February 24-27, 2000.
- European Winter Conference on Brain Research. “Cross-talk between calcium channels and ryanodine receptors.” Villars, Switzerland. March 11-18, 2000.
- NATO Workshop on Calcium Cross-talk in Excitable Tissue. “C-terminal tale of Ca2+ channel as a regulator of Ca2+ release.” Tuscany, Italy. April 26-30, 2000, (organizing chairman).
- 3rd International Symposium on Membrane Channels, Transporters and Receptors. “Dual regulation of Ca2+ signaling in atrial myocites.” Smolenice, Slovakia. June 4-7, 2000.
- Czechoslovakia National Academy of Sciences, Lecture Series : “PH Regulation of Nicotine Receptor.”, Prague, CZ. June 8, 2000
- Gordon Research Conference on Cardiac Regulatory Mechanisms. “Oxidant regulation of Ca2+ signaling.” Holderness, New Hampshire. July 17-23.
1999 - UCLA Heart Lab. "Carboxyl Tail of cardiac Ca2+ channel: possible role in Ca2+ signaling."
March 13.
- Symposium on Cardiac Electrophysiology (1949-1999): "Interaction of intracellular and extracellular ion channels in cardiac myocytes." Paris, France, Sept 8-10.
- AHA, Basic Science Lectures. "What genetic engineering in vivo has taught us." Nov. 7.
- Symposium on Cells, Channels and Signals: "Possible Molecular Sites for Ca2+ Cross-Signaling." Kiev, Ukraine Sep. 10-12
1998 - Gordon Conference on Cardiac Signal July 19-26.
- MDIBL Centennial Symposium, (Gifts from the Sea), "Ca2+ Signaling in the Heart: an Evolutionary Bonanza" July 24-25.
- "Calcium and Cell Function." University of Leuven, Belgium, September 17-19.
- Distinguished Lecturer of National Science Council, Taiwan, November 1-6.
1997 - First International Interdisciplinary Conference on Cardiovascular Medicine, Surgery, Science,
and Mechanics. “Two dimensional rapid confocal imaging of Ca2+ profiles during activation of Ca2+ current in cardiac myocytes. Washington, D.C., June 6-9.
- 13th annual Ernest Volwiler Distinguished Scientist Lecture. “The mysterious heart: The Quest for scientific solutions.” Lake Forest College, Chicago, April 3.
- “Ca2+ signaling in cardiac myocytes: Evidence from evolutionary and transgenic models.” Department of Pharmacology, University of Miami. March 28.
- “Rapid confocal imaging of Ca2+ signaling.” Department of Physiology and Medicine, UCLA Heart Lab, Los Angeles, CA. March 10.
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- University of Pennsylvania Medical Center, Pennsylvania Muscle Institute. “Ca2+
signaling in Ca2+ microdomains: insights from transgenic and evolutionary models.” Philadelphia, PA, January 27th.
1996
- Keynote speaker at the Annual Congress Chilean Society of Cardiology and Cardiovascular Surgery. “T-Calcium Channels its role in cardiovascular therapy”. Valdiva, Chile, December 6.
- “10th annual Goldberg Workshop: Analytical and quantitative cardiology from genetics to function,” Haifa, Israel, December 2-5.
- Meeting on low voltage activated T-type calcium channels. Montpelier, France, October 21-22.
- Gordon Research Conference. “Ca2+ signaling in ventricular myocytes of transgenic mice overexpressing Na+-Ca2+ exchanger”. Colby Sawyer College, New Hampshire, July 7-12.
1995 - Conference on “Calcium and cellular metabolism: transport and regulation.” Lectures on 1)
Ca2+ signaling between the ryanodine receptor and Ca2+ channels in heart; 2) Regulation of the Na+-Ca2+ exchanger by phosphorylation in cardiac myocytes; and 3) Signaling of adrenergic secretion in single chromaffin cells. Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay, October 1-6.
- Mount Desert Island Biological Laboratories, “In the beginning there was the Na+-Ca2+ exchanger.” MDIBL, Maine, August 4.
- Universidad Autonoma de Madrid, “Calcium signaling of adrenergic secretion in single chromaffin cells.” Madrid, Spain, June 28.
- Laboratorium für Biochemie der ETH Zürich, “Regulation of calcium transport in cardiac myocytes: the Na+-Ca2+ exchanger versus the Ca2+ channel.” Zürich, June 23.
- Sendai International Symposium on Molecular and Cellular Mechanisms of Cardiovascular Regulation. Sendai, Japan, May 10-12.
- Institute National de la Sante et de la Recherche Medicale, Centre Universitaire, Paris-Sud, "Ca signaling in cardiac myocytes: cross-talk between ryanodine and DHP receptors, Paris, France, February 24.
1994 - 9th Annual Goldberg Workshop on Molecular and Subcellular Cardiology: Effects on Structure
and Function, “Molecular mechanisms of Ca regulation and cross signaling” Haifa Israel, December 4-8.
- Japanese-German Joint Symposium on Physiological and Pathophysiological Regulation of Cardiovascular Receptors, Ion Channels, and Intracellular Signal Transduction, “Cross-talk between L-type Ca2+ channels and ryanodine receptors in rat ventricular myocytes. Osaka, Japan, October 20-22.
- Key Note speaker, Biophysical Society Annual Meeting, New Orleans, LA, March 7.
1993
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- Caribbean Neurobiology Institute, "Regulation and secretion in chromaffin cells," San Juan, Puerto Rico, March 29-30.
- American Cyanamid Corp., "Signaling of Ca2+ Release in Cardiac Myocytes: Ca2+ Channel vs. Na+-Ca2+ Exchanger," Pearl River, New York, November 5.
- XXII Reunion Anual Sociedad Argentina de Biofisica, "Regulation of Ca2+ channel and adrenergic secretion in bovine chromaffin cells," Rosario, Argentina, December 2-4.
- Buenos Aires Medical School, Institute of Cardiology, "Regulation of Ca2+ uptake and relaxation in mammalian cardiac myocytes," Universidad de Buenos Aires, Argentina, December 6.
1992 - Franz Gross Hypertension Symposium, Kronberg, Germany, March 5-7.
- Annual Cardiac Muscle Society lecture, FASEB, Anaheim, California, April 6.
- International Society for Heart Research, satellite symposium: "Basic and clinical aspects of cardiac inotropic agents," Osaka, Japan, May 8-9.
- The XIV World Congress of the International Society for Heart Research, Kobe, Japan, May 10-14.
- International Symposium on "Myocarditis/Dilated Cardiomyopathy - Pathogenesis and Clinical Implications," Essen, FRG, May 14-16.
- Gordon Conference on Cardiac Regulatory Mechanisms, Plymouth, New Hampshire, June 8-12.
- 2nd International Symposium on Mammalian Myocardium: Biochemical and Physiological Mechanisms Underlying the Heartbeat, University of Leeds, U.K., July 26-29.
- AAAS-NIH sponsored "Channel modulation and autonomic control," Westfields Conference Center, Manassas, Virginia, September 12-15.
- American Heart Association 65th Scientific Sessions, state-of-the-art speaker for session entitled, "Intracellular Calcium Activity and Cardiac Functions," co-chair session, "Modulation of Ion Channels," New Orleans, Louisiana, November 17-19.
1991 - UCLA, Born Professor Lectureship, Los Angeles, CA, January 7-11.
- Biophysical Society Symposium, speaker on E-C coupling, and chairman and organizer of ion channel regulation symposium, Baltimore, Maryland, February 18-21.
- University of Leuven, Muscle Symposium, Leuven, Belgium, March 3-8.
- Max-Planck Institute for Neurophysiology, Symposium on Ion Channel Regulation, Munich, FRG, March 23-27.
- A.A. Bogomoletz Institute of Physiology, Academy of Science of the Ukraine. Kiev, Ukraine, April.
- International Society of Cardiovascular Pharmacology, K+ Channels in Ischemia and Heart Disease, Geneva, Switzerland, April 22-24.
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- NATO Advanced Research Workshop, "Intracellular Regulation of Ion Channels," chairman, Il Ciocco, Italy, April 26-30.
- American Heart Association, Conference on the Structure and Function of Ion Channels in the Heart and Vascular System, Chicago, Illinois, May 8-11.
- International Society for Heart Research, Glasgow, Scotland, June 27-30.
- APS Specialty Conference, "From Channels to Cross Bridges," speaker and chairman, Bar Harbor, Maine, July 13-17.
- Symposium on Ionic Currents and Ischemia, Prior of Corsendonck, Turnhout, Belgium, organizer and invited speaker, September 14-15.
- 5th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research, "Regulation of Cardiac Calcium Channels," Houston, Texas, September 25-28.
- Universidad Autonoma de Madrid, Calcium as an Intracellular Signal, Madrid, Spain. October 16.
- American Heart Association, organizer, "E-C Coupling in Heart," Dallas, Texas, November.
- Takeda Foundation Symposium on Peptide Regulation of Cardiovascular Function, Kyoto, Japan, December 5-7.
- Tokyo Society of Medical Science Lecture, December 10.
1989 - Research Institute of Environmental Medicine, Japan-U.S. Symposium on Cardiovascular
Drugs, Hawaii, February 1-4.
- Merck, Sharp and Dohme, Inc., April 19.
- National Institutes of Health, Laboratory of Developmental Neurobiology, May 16.
- Gordon Research Conference on Cardiac Inotropic Agents, New Hampshire, chair of E-C coupling, Session I, June 12-16.
- XXXI International Congress of Physiological Sciences, Symposium on Ionic Regulation in Nervous Tissue, Helsinki, July 5-8.
- Society for Neuroscience, Fidia Georgetown Research Foundation Symposium on Neurotoxicity of Excitatory Amino Acids, Phoenix, Arizona, October 26-28.
- National Science Council Lectureship Program, Taipei, Taiwan, December 10-19.
1988 - Ciba Foundation Symposium, Proton Passage Across Cell Membranes, London, February 9-11.
- Mill Hill National Labs, London, Role of Ca2+ channels in cardiac contraction, February 11.
- National Institute for Physiology, U.S.-Japan Seminar, Okazaki, April 16-19.
- Japan Heart Foundation International Symposium, Basic Mechanisms of Arrhythmias, Tokyo, Japan, April 22-23.
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- Bayer Centenary Symposium, The Calcium Channel: Structure, Function and Implications, Stresa, Italy, May 11-14.
- Ludwig-Maximilians-Universitat, New Concepts in Viral Heart Disease, Munich, May 25-28.
- Gordon Research Conference, Excitation-Contraction Coupling, Plymouth, New Hampshire, June 13-17.
- FASEB Research Conference, Electrophysiological Mechanisms of Propagation in and Activation of Cardiac and Smooth Muscle, Saxtons River, Vermont, August 14-19.
- American Heart Association, 61st Scientific Sessions, Washington, D.C., November 11-14.
- Institut für Physiologie und Kardiologie, Universität Erlangen Nurnberg, Workshop on Quantitative Spectroscopy in Tissue, November 15-16.
1987 - Ion Channel Modulation Symposium Honoring Roger Eckert, UCLA, Los Angeles, February
26-March 1.
- FASEB Summer Research Conference on Calcium and Cell Function, Saxtons River, Vermont, July 12-17.
- Georgetown University, Fidia Georgetown Institute for the Neurosciences, Washington, D.C., October 9.
- The Upjohn Company, Kalamazoo, Michigan, November 2.
- University of Puerto Rico, 20th Annual Symposium, Institute of Neurobiology, Od San Juan, Puerto Rico, November 10-13.
- Yale University, Department of Physiology, Proton-induced transformation of Ca2+ channel.
1986 - National Academy of Sciences, Bratislava, Czechoslovakia, April 14-17.
- National Academy of Sciences, Berlin, DDR, May 20-23.
- University of Halle, Department of Physiology, Halle, DDR, May 20-23.
- Cardioimage 1986. Scanning the spread of electrical activity in the heart using a new laser scanner. Monaco.
- Gordon Research Conference on Cardiac Inotropic Agents, Plymouth, New Hampshire (chairman), June 11-15.
- 8th Annual Meeting of the International Society for Heart Research - American Section and Satellite symposium of the 30th International Physiological Congress, Winnipeg, Canada, July 8-11.
- XXX Congress of International Union of Physiological Sciences, Vancouver, Canada, July 11-14.
Before 1986 - Yale University, Two Ca2+ channels and their role in E-C coupling. New Haven, Conn., 1985.
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- Univ. of Texas Health Sciences Center. E-C coupling in heart muscle. Galveston, Texas, 1985.
- University of Paris. Rapid photoconversion of calcium antagonists in heart muscle: implications on calcium transport and E-C coupling. Paris, France, 1983.
- Université Claude Bernard. Rapid photoconversion of calcium antagonists in heart muscle: implications on calcium transport and E-C coupling. Lyons, France, 1983.
- Cardiovascular Institute. The internal calcium stores in heart muscle. Midhurst, England, 1983.
- Mayo Clinic. Rapid photoconversion of calcium antagonists in heart muscle: implications on calcium transport and E-C coupling. Rochester, Minnesota, 1983.
- Symposium on Ion Selective Electrodes. Depletion of Ca2+ from the extracellular space during a single action potential and its relation to development of tension in heart muscle: experiments using a Ca2+-sensitive dye. Erlangen, West Germany, 1983.
- University of Saar-Homburg. E-C coupling in heart muscle: some old ideas and new experiments. Saar Homburg, West Germany, 1982.
- National Academy of Sciences. New laser scanning system to monitor the spread of electrical activity in whole heart. Czechoslovakia, 1982.
- Charles University. New laser scanning system to monitor the spread of electrical activity in whole heart. Prague, Czechoslovakia, 1982.
- University of Heidelberg. New laser scanning system to monitor the spread of electrical activity in whole heart. Heidelberg, West Germany, 1982.
- IUPS Satellite Symposium. Ca2+ in cardiac and coronary muscle fiber activity. Organizing Committee, 1980.
- Satellite Symposium. Ion-selective microelectrodes & their use in excitable tissues. Prague, 1980.
- Federation Proceeding Symposium on Extracellular Implications of Ionic Accumulation in Excitable Tissue. R Orkand, organizer. Dallas, Texas, 1979.
- Gordon Research Conference. Ionic channels in muscle & other excitable membranes. NH, 1979.
- American Society for Pharmacology and Experimental Therapeutics Symposium. Aquatic animals as models in biomedical research. August, 1979.
- Czechoslovakia Academy of Science, Physiology Society. K+ fluxes in heart, Prague, 1978.
- International Union of Physiological Sciences, 27th International Physiological Congress. Excitation-contraction coupling round-table discussion. Paris, France, 1977.
- 27th International Physiological Congress Satellite Symposium on Voltage Clamp in Muscle. Lord Adrian and Denis Noble, organizers. Pointer, France, 1977.
- European Society of Cardiology. 4th Workshop on Contractile Behavior of Heart: Relaxation and diastole. Fritz Meijler and Dirk Brutsaert, organizers. Utrecht, The Netherlands, 1977.
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- Pahlavi University and Iranian Physiology Society Symposium on Cardiac Muscle. Organizer of symposium and editor of its proceedings. Shiraz, Iran, 1977.
- University of Tehran, Iran. Visiting lecturer, June 1976.
- Indian Pharmacological Society Symposium on Digitalis. Madras, 1975.
- Gordon Research Conference. A carrier-mediated transport of ions during the plateau of cardiac action potential. New Hampshire, 1974.
- Gordon Research Conference. Session chairman, "E-C coupling of heart" New Hampshire, 1974.
- Annual Meeting of the American College of Cardiology. Role of plasma membrane in control of transcellular Ca2+ movement. Washington, D.C., 1971.
- Cardiac Muscle Society - The Abraham Shanes Lecture. Evolution of excitation-contraction coupling: from frog to mammals. Chicago, Illinois, 1971.
- American Physiological Society Symposium on Muscle Contraction. Excitation-contraction coupling in muscle: Where does Ca2+ come from? Kansas City, Missouri, 1971.
- International Symposium on Cardiac Arrhythmias. Pharmacological dynamics of anti-arrhythmic agents, electrical-mechanical coupling. Philadelphia, Pennsylvania, 1971.
- Gordon Research Conference on Heart Muscle, Excitation-contraction coupling in heart: a comparative study. Holderness, New Hampshire, 1970.
- American Heart Association. Excitation-contraction coupling in heart muscle. Dallas, TX, 1969.
