Curriculum Vitae - Medical University of South...

Curriculum Vitae

DATE: November 2010

NAME: Truman R. Brown

CITIZENSHIP: USA

EDUCATION:1959 - 1961 Phillips Exeter Academy1961 - 1964 B.S. Massachusetts Institute of Technology (Mathematics)1964 - 1965 University of Maryland (Physics)

1965 - 1970 Ph.D. Massachusetts Institute of Technology (Physics)Thesis Title: Investigation of The Vortex State In Type-II Superconductors By Means of An Atomic BeamThesis Supervisor: John G. KingPublication: Atomic-Bean Observations of The Magnetic Field Outside A Type-II Superconductor Physical Review Letters 26(16): 969-972, 1971

PROFESSIONAL ORGANIZATIONS AND SCIENTIFIC SOCIETIES:2007 Chairman, Experimental NMR Conference

Experimental Nuclear Magnetic Conference1999 - 2008 * Executive Committee2006 - 2007 * Chairman1997 - Present American Diabetes Association 1968 - Present American Physical Society 1980 - Present Biophysical Society 1983 - Present International Society of Magnetic Resonance in Medicine 1986 - 1990 Member, Board of Trustees 1983 - 1988 Chairman, Education Committee 1987 Chairman, Nominating Committee 1988 - 1989 Chairman, Scientific Program Committee 1988 - 1990 Member, Executive Committee 1983 - Present American College of Radiology 1990 - 1993 Society of Magnetic Resonance Imaging 1992 Member, Scientific Program Committee

ACADEMIC APPOINTMENTS:2001 - Present Percy Kay & Vida L. W. Hudson Professor of Biomedical

EngineeringProfessor of RadiologyDirector of MR ResearchColumbia University, NY

1995 - 2000 Lecturer, Depart. of Radiology, Columbia University, NY1988 - 2000 Adjunct Professor, Dept. of Biochemistry &

Biophysics, University of Pennsylvania, Philadelphia, PA1983 - 2000 Chairman, NMR and Medical Spectroscopy

Senior Member, Division of Medical ScienceFox Chase Cancer Center, Philadelphia, PA

1971 - 1983 Member of Technical StaffBell Laboratories, Murray Hill, NJ

1970 - 1971 Instructor in PhysicsMassachusetts Institute of Technology, Boston, MA

Truman R. Brown - CV

HONORS:

Governmental Service:Fellow, American Physical SocietyDiagnostic Radiology Study Section of the National Institutes of HealthMember - (1990-1995)Chairman - (1993-1995)

Awards:2005 - 2006 The Department of Radiology of The

Columbia University Medical Center “Sadek K. Hilal Faculty Research Award for Excellence in Research”

Active Grants:

1 R21EB006877 (Brown) 03/01/2008 - 02/28/2011NIH $431,796Real Time Motion Correction for Brain MRIThe purpose of this study is to implement and validate a novel scheme for prospective correction of MRI motion artifact that operates in parallel with the acquisition of imaging data.

1 R33 DK70301 (Brown) 09/29/2004 - 07/31/2010NIH $990,877Metabolic Patterns in 1H NMR Spectra of BiofluidsThe goal of this project is to apply BSD and cNMF to analyze a series of NMR spectra of urine acquired from toxicology studies of rats and mice that have been preprocessed by the techniques of preprocessing procedures for series of high resolution 1H NMR spectra of urine to improve spectral quality enable PR procedures to identify any underlying biochemically relevant spectral patterns.

5R33 DK070301-03 (Brown) 08/01/2006 - 07/31/2009 NIH $147,356Metabolic Patterns in 1H NMR Spectra of Biofluids (Supplement)The goal of this project is to further extend the development of HiRes software and to establish intergrate website.

1 R01 CA118559 (Brown) 05/01/2007 - 02/28/2011 NIH $4,321,352In Vivo 31P & 1H MRS Studies of Non-Hodgkin’s LymphomaInvestigating the hypothesis that metabolic levels in tumors also serve as predictors of treatment response to that this information can be used to individualize treatment. We propose to conduct a multi-center trial using current therapies to accrue sufficient cases to justify a clinical trial in which patients determine to be at high risk for treatment failure.

NIH (Brown) 09/26//2007 - 08/31/20091R03EB008203-01 $149,058Intergration of Metabolomics in Neuroimaging: Software for Brain NMR SpectroscopyThe goal of this project is to improve the automatic importation of raw data by including file formats from all scanner brands as well as interface spectroscopy data with other neuro-imaging software tools.

5R21EB004730 (Sajda) 09/01/2004 - 06/30/2008NIH $917,505A Non-Invasive Single-Trial In-Vivo Neuroimaging System

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The overall goal of this project is to develop an integrated single-trial system for neuroimaging which combines high-density electroencephalography (EEG) with simultaneous functional magnetic resonance imaging (fMRI), and to use this system to investigate variability in neural processing.

P01 AG07232 (Mayeux) 07/01/2004 - 06/30/2009NIH/NIA $1,518,109The Epidemiology of Dementia in an Urban CommunityCore Leader for the Imaging Core in this PPG which is a continuation of a cross-cultural investigation of dementia in an upper Manhattan community.

Duke University Subcontract (Charles/Stern) 09/01/2004 - 08/31/2009AD Neuroimaging Initiative $463,942

R01 AG026158 (Stern) 09/15/2004 - 07/31/2009NIH/NIA $1,868,622Imaging of Cognition, Learning and Memory in AgingThe overall goal is to identify in young and elderly subjects brain networks who’s expression varies as a function of task load on two tasks, delayed match to sample task and continuous non-verbal recognition.

DARPA/DTRA (Brenner) 02/01/2007 - 01/31/2010HDTRA1-07-01 $279,503Metabolomics Based Rapid Biodosimetry for Partial Body Radiation ExposureThe purpose of this study is to identify one characterized metabolomic signature of partial exposure in a mouse model.

1R01MH085092-01 (Sajda) 08/01/2009 – 7/31/2014NIH $1,205,000Multimodal Neuroimaging for Mapping Decision Making in the Human Brain

Pending:

R21AN3204181 (Brown) 01/01/2010 - 12/31/2011NIH/NIBIB $250,000Water Line Shape in Brain Tissue

RC1NA000034-01(Brown, Connolly, Krakauer, MPI) 09/30/2009- 09/29/2011In vivo quantification and tracking of neural progenitor cells $542,276utilizing magnetic resonance spectroscopy

Inactive Grants:

P01CA41078 (Brown) 1987 - 1990National Institute of Health $2,948,873NMR Studies of Tumor Development and Metabolism

P01-CA41078 (Brown) 1991 - 1996National Institute of Health (NCI) $4,908,603NMR Studies of Metabolism in Cancer and Diabetes

PO1-CA41078 (Brown) 1997 - 2002National Institute of Health (NCI) $7,927,358NMR Studies of Human Cancer

R01CA48261 (Brown) 1988 - 1991National Institute of Health $515,438

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Multi-Variant Analysis of Soft Tissue Sarcomas by MRI

R01-CA54339 (Brown) 1992-1997National Institutes of Health (NCI) $709,506Development of Chemical Shift Imaging Techniques

U01-CA62556(An Eight Institution Cooperative Study Initiated & Chaired by T.R. Brown)National Institutes of Health (NCI) 1995 - 2001 Predicting Tumor Response by 31P MRS $1,363,975

U01-CA62556-06S1(A funded non-competitive extension of the above grant)National Institutes of Health (NCI) 2002 - 2005Predicting Tumor Response by 31P MRS $1,178,001

R01-CA66235 (Brown) 1995 - 1999National Institutes of Health (NCI) $781,553MRI to Assess Response of Breast Cancer Bone Metastases

R01-CA56960 (Brown) 1991 - 1997National Institutes of Health (NCI) $1,053,78031P MRS for Prognosis of Bone and Soft Tissue Sarcomas

R01-DK50317 (Brown) 1995 - 1997National Institute of Health $100,000James D. Shannon Director’s AwardMetabolism of Dietary Amadori Products

CU51772204 (Brown) 2004 - 2006Department of Justice $238,246Evaluation of Steroids Purported to be in Dietary Supplements on Skeletal Muscle Growth and Other Tissues of the Guinea Pig

1R13GM074561 (Brown) 04/01/2005 - 03/31/2008 National Institute of Health $15,000Experimental NMR ConferenceThis is a grant for students to attend the ENC Conference.

UNIVERSITY COMMITTEES:2001 - Present Columbia University

Department of Biomedical EngineeringExecutive CommitteeGraduate Studies CommitteeDepartment of RadiologyExecutive CommitteeHealth Sciences Strategic InitiativesVarious Tenure Reviews

1988 - 2000 University of PennsylvaniaThesis Committee: 4 Ph.D. CommitteesQualification CommitteeStudent Activities Committee

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TEACHING EXPERIENCE:2004 - Present Principles of Magnetic Resonance Imaging2002 - 2004 Bioethics for Biomedical Engineers1988 - 2000 Adjunct Professors in Biochemistry and Biophysics,

University of Pennsylvania1983 - 1988 Responsible For Spectroscopy Courses at ISMRM

Specific Continuing Medical Education Courses1995 ISMRM: “Advanced MR Spectroscopy”1996 ISMRM: “Advanced Data Analysis Techniques Applied to Spectroscopy”1997 ISMRM: “MRS Spectral Analysis in the Frequency

Domain”

THESIS SPONSORSHIP: 1993 - 1997 Name: Zhiqiang Liu

Current Title: UnknownDegree Level: Ph.D.Title: A New Bayesian Approach to Process Chemical Shift Imaging Data

2003 - 2007 Name: Kristi HultmanCurrent Title: UnknownDegree Level: Ph.D.Title: Specific Cell Detection Using Iron Oxide Nanoparticles

2004 - 2008 Name: Matt NeimarkCurrent Title: UnknownDegree Level: Ph.D.Title: Theoretical Modeling and Non-Invasive Measurement of Brain Temperature for Intracarotid Cold Saline Infusion Therapy

EXTERNAL EXAMINER:1993 Name: Jerome Jeneson

University of Utrecht, The NetherlandsCurrent Title: Assistant Professor, Biomedical Engineering, University of WashingtonDegree Level: Ph.D.

EDITORIAL POSITIONS:1987 - 1995 North American Editor, NMR in Biomedicine1987 - Present Editorial Board, NMR in Biomedicine

BIBLIOGRAPHY:

Original Papers:

1. Brown, T.R. and King, J.G.; Atomic Beam Study of Nb In The Vortex State. Physical 55: 518-521, 1971.

2. Brown, T.R. and King, J.G.; Atomic-Beam Observations of The Magnetic Field Outside A Type-II Superconductor. Physical Review Letters 26 (16): 969-972, 1971.

3. Brown, T.R. and Grimes, C.C.; Observation of Cyclotron Resonance in Surface-Bound Electrons on Liquid Helium. Physical Review Letters 29 (18): 1233-1236, 1972.

4. Grimes, C.C. and Brown, T.R.; Direct Spectroscopic Observations of Electrons in Image-Potential States Outside Liquid Helium. Physical Review Letters 32 (6): 280-283, 1974.

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5. Arthur, J.R. and Brown, T.R.; Velocity Distributions of As2 and As4 Scattered From GaAs. Journal of Vacuum Science and Technology 12 (1): 200-203, 1975.

6. Hockney, R.W. and Brown, T.R.; A Lambda Transition in A Classical Electron Film. J. Phys. C.: Solid State Phys. 8: 1813-1822, 1975.

7. Grimes, C.C., Brown, T.R., Burns, M.L. and Zipfel, C.L.; Spectroscopy of Electrons in Image-Potential-Induced Surface States Outside Liquid Helium. Physical Review 1391: 140-147, 1976.

8. Brown, T.R. and Hockney, R.W.; A Phase Transition in A Classical Electron Film. Surface Science 58: 295-296, 1976.

9. Zipfel, C.L., Brown, T.R. and Grimes, C.C.; Measurement of The Velocity Autocorrelation Time In A Two-Dimensional Electron Liquid. Physical Review Letters 37 (26): 1760-1763, 1976.

10. McCall, S.L., Brown, T.R. and Passner, A.; Improved Optical Stellar Image Using A Real-Time Phase Correction System-Initial Results. Astrophys. J. 211: 463, 1977.

11. Brown, T.R. and Ogawa, S.; 31P Nuclear Magnetic Resonance Kinetic Measurements on Adenylatekinase. Proc. Natl. Acad. Sci. USA 74 (9): 3627-3631, 1977.

12. Brown, T.R., Ugurbil, K. and Shulman, R.G.; 31P Nuclear Magnetic Resonance Measurements of ATPase Kinetics in Aerobic Escherichia Coli Cells. Proc. Natl. Acad. Sci. USA 74 (12): 5551-5553, 1977.

13. Ogawa, S., Rottenberg, H., Brown, T.R., Shulman, R.G., Castillo, C.L. and Glynn, P.; High-Resolution 31P Nuclear Magnetic Resonance Study of Rat Liver Mitochondria. Proc. Natl. Acad. Sci. USA 75 (4): 1796-1800, 1978.

14. Cohen, S.M., Ogawa, S., Rottenberg, H., Glynn, P., Yamane, T., Brown, T.R. and Shulman, R.G.; 31P Nuclear Magnetic Resonance Studies of Isolated Rat Liver Cells. Nature 273 (5663): 554-556, 1978.

15. Ugurbil, K., Brown, T.R., den Hollander, J.A., Glynn, P. and Shulman, R.G.; High-rsolution 13C Nuclear Magnetic Resonance Studies of Glucose Metabolism In Escherichia Coli. Proc. Natl. Acad. Sci. USA 75 (8): 3742-3746, 1978.

16. Brown, T.R., den Hollander, J.A., Shulman, R.G. and Ugurbil, K.; 13C NMR Studies of Glycolysis in Suspensions of Escherichia Coli Cells. Frontiers of Biological Energetics 2: 1365-1370, 1978.

17. Brown, T.R., Gadian, D.G., Garlick, P.B., Radda, G.K., Seeley, P.J. and Styles, P.; Creatine Kinase Activities In Skeletal and Cardiac Muscle Measured By Saturation Transfer NMR. Frontiers of Biological Energetics 2: 1341-1349, 1978.

18. Brown, T.R. and Ogawa, S.; 31p NMR Kinetic Measurement on Adenlytate Kinase. Biomolecular Structure and Function: 369-376, 1978.

19. Shulman, R.G., Brown, T.R., Ugurbil, K., Ogawa, S., Cohen, S.M. and Den Hollander, J. A.; Cellular Applications of 31P and 13C Nuclear Magnetic Resonance. Science 205: 160-166, 1979.

20. Den Hollander, J.A., Brown, T.R., Ugurbil, K. and Shulman, R.G.; 13C Nuclear Magnetic Resonance Studies of Anaerobic Glycolysis in Suspensions of Yeast Cells. Proc. Natl. Acad. Science USA 76: 6096-6100, 1979.

21. Ugurbil, K., Shulman, R.G. and Brown, T.R.; High Resolution 31p and 13c Nuclear Magnetic Resonance Studies of Escherichia Coli Cells in Vivo. Academic Press: 537-589; 1979.

22. Brown, T.R.; Saturation Transfer in Living Systems. Phil. Trans. R. Soc. Lond. B289: 441-444, 1980.

23. Gadian, D.G., Radda, G.K., Brown, T.R., Chance, E.M., Dawson, M.J. and Wilkie, D.R.; The Activity of Creatine Kinase in Frog Skeletal Muscle Studied by Saturation-Transfer Nuclear Magnetic Resonance. Biochem. J. 194: 215-228, 1981.

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24. Den Hollander, J.A., Ugurbil, K., Brown, T.R. and Shulman, R.G.; 31P Nuclear Magnetic Resonance Studies of The Effect of Oxygen Upon Glycolysis In Yeast. Biochem. 20: 5871-5880, 1981.

25. Ugurbil, K., Guernsey, D.L., Brown, T.R., Glynn, P., Tobkes, N. and Edelman, I.S.; 31P Nuclear Magnetic Resonance Studies of Intact Anchorage-Dependent Mouse Embryo Fibroblasts. Proc. Natl. Acad. Sci. USA 78: 4843-4847, 1981.

26. Brown, T.R.; Is Creatine Phosphokinase in Equilibrium in Skeletal Muscle? Federation Proceedings 41 (2): 174-75, 1982.

27. Meyer, R.A., Kushmerick, M.J. and Brown, T.R.; Application of 31P Nuclear Magnetic Resonance Spectroscopy to The Study Of Striated Muscle Metabolism. Am. J. Physiol. 242: C1-C11, 1982.

28. Brown, T.R., Kincaid, B.M. and Ugurbil, K.; NMR Chemical Shift Imaging in Three Dimensions. Proc. Natl. Acad. Sci. USA 79: 3523-3526, 1982.

29. Kushmerick, M.J., Meyer, R.A. and Brown, T.R.; Phosphoorus NMR Spectroscopy of Cat Biceps and Soleus Muscles. Advances in Exper. Med. & Biology 159: 303-25, 1983.

30. Garlick, P.B., Brown, T.R., Sullivan, R.H. and Ugurbil, K.; Observation of A Second Phosphate Pool in The Perfused Heart By 31P NMR; Is This Mitochondrial Phosphate? J. Mol. Cell Cardiol. 15: 855-858, 1983.

31. Stevenson, D.E., Warner, D.D. and Brown, T.R.; BIOBELL--A Simulation System For Biochemistry and Biophysics. Comput. Biol. Med. 14: 35-46, 1984.

32. Meyer, R.A., Brown, T.R. and Kushmerick, M.J.; Phosphorus NMR of Fast and Slow-Twitch Muscle. Am. J. Physiol. 248: C279-287, 1985.

33. Brown, T.R.; Cardiac Energy Metabolism: Contributions From Nuclear Magnetic Resonance. Circ. 75: IV18-IV21, 1985.

34. Brown, T.R.; Applications of Nuclear Magnetic Resonance to the Study of Parasitic Disease. Pontifici.ae Academiae Scientiarvm Scripta Varia. 61: 121-127, 1985.

35. Den Hollander, J.A., Ugurbil, K., Brown, T.R., Bednar, M., Redfield C. and Shulman, R.G.; Studies of Anaerobic and Aerobic Glycolysis in Saccharomyces Cerevisiae. Biochem. 25 (1): 203-11, 1986.

36. Meyer, R.A., Brown, T.R., Krilowicz, B.L. and Kushmerick, M.J.; Phosphagen and Intracellular pH Changes During Contraction of Creatine-Depleted Rat Muscle. Am. J. Physiol. 250: C264-C274, 1986.

37. Kushmerick, M.J., Dillon, P.F., Meyer, R.A., Brown, T.R., Krisanda, J.M. and Sweeney, H.L.; 31P NMR Spectroscopy, Chemical Analysis, and Free Mg2+ of Rabbit Bladder and Uterine Smooth Muscle. J. Biol. Chem. 261: 14420-14429, 1986.

38. Graham, R.A., Meyer, R.A., Szwergold, B.S. and Brown, T.R.; Observation of Myo-Inositol 1, 2- (Cyclic) Phosphate in a Morris Hepatoma by 31P NMR. J. Biol. Chem. 262: 35-37, 1987.

39. Gatenby, R.A. and Brown, T.R.; Tumor Reoxygenation Using Direct Injection of Oxygenated Saline. Investigative Radiology 22: 404-407, 1987.

40. Nelson, S.J. and Brown, T.R.; A New Method for Automatic Quantification of 1-D Spectra With Low Signal To Noise Ratio. J. Magn. Reson. 75: 229-243, 1987.

41. Brown, T.R., Graham, R.A., Szwergold, B.S., Thoma, W.J. and Meyer, R.A.; Phosphorylated Metabolites in Tumors, Tissues and Cell Lines. Annals of The New York Academy Of Sciences 508: 229-240, 1987.

42. Brown, T.R.; Localization Techniques Push Forward Clinical Value of MR Spectroscopy. Diagnostic Imaging 359-369, 1987.

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43. Szwergold, B.S., Graham, R.A. and Brown, T.R.; Observation of Inositol Pentakis, and Hexakis-Phosphates in Mammalian Tissues by 31P NMR. Biochem. Biophys. Res. Comm. 149 (3): 874-881, 1987.

44. Meyer, R.A. and Brown, T.R., Diffusion Measurements by Microscopic NMR Imaging. J. Magn. Reson. 76: 393-399, 1988.

45. Unger, E.C., Cohen, M.S., Gatenby, R.A., Clair, M., Brown, T.R., Nelson, S.J. and McGlone, J.S.; Single Breath-Holding Scans of The Abdomen Using FISP and FLASH at 1.5 T. J. Comp. Assist. Tomogr. 12 (4): 575-583, 1988.

46. Buchthal, S.D., Hardy, M.A. and Brown, T.R.; Assessing The Value of Identifying The Presence of Human Malignant Disease in Plasma by Proton Nuclear Magnetic Resonance Spectroscopy. Am. J. Med. 85 (3): 528-532, 1988.

47. Szwergold, B.S., Brown, T.R. and Freed, J.J.; Bicarbonate Abolishes Intracellular Alkalinization In Mitogen-Stimulated NIH 3T3 cells. Annals of The New York Academy Of Sciences 551: 277-9, 1988.

48. Meyer, R.A., Fisher, M.J., Nelson, S.J. and Brown, T.R.; Evaluation of Manual Methods For Integration of in vivo Phosphorus NMR Spectra. NMR In Biomed. 1: 131-135, 1988.

49. Unger, E.C., Cohen, M.S. and Brown, T.R.; Gradient-Echo Imaging Of Hemorrhage at 1.5 Tesla. Magn. Reson. Imag. 7 (2): 163-172, 1989.

50. Szwergold, B.S., Brown, T.R. and Freed, J.J., Bicarbonate Abolishes Intracellular Alkalinization in Mitogen-Stimulated 3T3 Cells. J. Cell Physiol. 138 (2): 227-235, 1989.

51. Szwergold, B.S., Kappler, F., Brown, T.R., Pfeffer, P. and Osman, S.F.; Identification of D-Sorbitol 3-Phosphate In The Normal And Diabetic Mammalian Lens. J. Biol. Chem. 264 (16): 9278-9282, 1989.

52. Brown, T.R., Buchthal, S.D., Murphy-Boesch, J., Nelson, S. and Taylor, J.; A Multi-Slice Sequence For 31P in vivo Spectroscopy: 1D Chemical Shift Imaging With An Adiabatic-Half Passage Pulse. J. Magn. Reson. 82: 629-633, 1989.

53. Nelson, S.J. and Brown, T.R.; The Accuracy Of Quantification From 1D NMR Spectra Using The PIQABLE Algorithm. J. Magn. Reson. 84: 95-109, 1989.

54. Israel, J., Unger, E., Buetow, K., Brown, T.R., Blumberg, B. and London, W.T.; Correlation Between Liver Iron Content and Magnetic Resonance Imaging In Rats. Magn. Reson. Imag. 7: 629-634, 1989.

55. Buchthal, S., Thoma, W.T., Taylor, J.S., Murphy-Boesch, J., Nelson, S.J. and Brown, T.R.; In vivo T1Values of Phosphorus Metabolites in Human Liver and Muscle Determined at 1.5T By Chemical Shift Imaging. NMR In Biomed. 2: 298-304, 1989.

56. Szwergold, B.S., Kappler, F. and Brown, T.R.; Identification of fructose 3-Phosphate in The Lens of Diabetic Rats. Science 247: 451-454, 1990.

57. Vigneron, D.B., Nelson, S.J., Murphy-Boesch, J., Kelley, D.A.C., Kessler, H.B., Brown, T.R. and Taylor, J.S.; Chemical Shift Imaging Of Human Brain: Axial, Sagittal, and Coronal P-31 Metabolite Images. Radiology 177 (3): 643-649, 1990.

58. Jeneson, J.A.L., Taylor, J.S., Willard, T.S., Vigneron, D., Carvajal, L., Nelson, S.J. and Brown, T.R.; 1H MR Imaging of Anatomical Compartments Within The Finger Flexor Muscles of The Human Forearm. Magn. Reson. Med. 15: 491-496, 1990.

59. Petersen, A., Szwergold, B.S., Kappler, F., Weingarten, M. and Brown, T.R.; Identification of Sorbitol 3-Phosphate and Fructose 3-Phosphate in Normal and Diabetic Human Erythrocytes. J. Biol. Chem. 265: 17424-17427, 1990.

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60. Szwergold, B.S., Kappler, F., Cohen, L.H., Nanavati, D. and Brown, T.R.; Identification of a Naturally Occurring Methyl-Ester Of Phosphate, Methyl-Phosphorylcholine (Methyl-2-(N,N,N Trimethylamino) Ethyl Phosphate), in The Eggs of The Sea Urchin S. Purpuratus. Biochem. Biophys. Res. Commun. 172 (2): 855-861, 1990.

61. Meyer, R.A., Adams, G.R., Fisher, M.J., Dillon, P.F., Krisanda, J.M., Brown, T.R. and Kushmerick, M.J.; Effect of Decreased pH on Force and Phosphocreatine in Mammalian Skeletal Muscle. Canadian Journal of Phys. & Pharma. 69 (2): 305-10, 1991.

62. Graham, R.A., Brown, T.R. and Meyer, R.A.; An ex vivo Model For The Study of Tumor Metabolism by NMR: Characterization of The 31P Spectrum of The Isolated Perfused Morris Hepatoma 7777. Cancer Research 51 (3): 841-849, 1991.

63. Nelson, S.J. and Brown, T.R.; Peak Detection and Quantification in NMR Spectra Using The PIQABLE Algorithm. J. Magn. Reson. 13: 14-21, 1991.

64. Nelson, S.J., Taylor, J.S., Vigneron, D.B., Murphy-Boesch, J. and Brown, T.R.; Metabolite images of The Human Arm: Changes in Spatial and Temporal Distribution of High Energy Phosphates During Exercise. NMR In Biomedicine 4 (6): 268-273, 1991.

65. Taylor, J.S., Vigneron, D.B., Murphy-Boesch, J., Nelson, S.J., Kessler, H.B., Coia, L., Curran, W. and Brown, T.R.; Free Magnesium Levels in Normal Human Brain and Brain Tumors: 31P Chemical Shift Imaging Measurements at 1.5T. PNAS 88 (15): 6810-6814, 1991.

66. Nelson, S.J., Vigneron, D.B. and Brown, T.R.; Detection of Significant Features and Statistical Analysis of 2D And 3D Images of 31P Metabolites. Magn. Reson. Med. 25 (1): 85-93, 1992.

67. Petersen, A., Kappler, F., Szwergold, B.S. and Brown, T.R.; Fructose Metabolism in The Human Erythrocyte: Phosphorylation to Fructose 3-Phosphate. Biochem. J. 284: 363-366, 1992.

68. Marano, C.W., Szwergold, B.S., Kappler, F., Brown, T.R. and Matschinsky, F.M.; Human Retinal Pigment Epithelial Cells Cultured in Hyperglycemic Media Accumulate Increased Amounts of Glycosaminoglycan Precursors. Invest. Ophthalmol. and Visual Sci. 33 (9): 2619-2625, 1992.

69. Jeneson, J.A.L., Nelson, S.J., Vigneron, D.B., Taylor, J.S., Murphy-Boesch, J. and Brown, T.R.; Two Dimensional 31P Chemical Shift Imaging of Intramuscular Heterogeneity in Exercising Human Forearm Muscle. Amer. J. Physol. 263 (2P + 1): C357-C364, 1992.

70. Brown, T.R.; Practical Applications of Chemical Shift Imaging. NMR In Biomed. 5 (5): 238-243, 1992.

71. Kushmerick, M.J., Meyer R.A. and Brown, T.R.; Regulation of Oxygen Consumption in Fast and Slow Twitch Muscle, Am. J. Physiol. 263: C598-606, 1992.

72. Negendank, W.G., Brown, T.R., Evelhoch, J.L., Griffiths, J.R., Liotta, L.A., Margulis, A.R., Morrisett, J.D., Ross, B.D. and Shtern, F.; Proceedings of A National Cancer Institute Workshop: MR Spectroscopy and Tumor Cell Biology. Radiology 185 (3): 875-83, 1992

73. Jeneson, J.A., van Dobbenburgh, J.O., van Echteld, C.J., Lekkerkerk, C., Janssen, W.J., Dorland, L., Berger, R. and Brown, T.R.; Experimental Design of 31P MRS Assessment of Human Forearm Muscle Function: Restrictions Imposed By Functional Anatomy. Magnetic Resonance in Med. 30 (5): 634-40, 1993.

74. Murphy-Boesch, J., Stoyanova, R., Srinivasan, R., Willard, T., Vigneron, D., Nelson, S., Taylor, J.S. and Brown, T.R.; Proton-Decoupled P-31 Chemical Shift Imaging of The Human Brain in Normal Volunteers. NMR In Biomedicine 6 (3): 173-180, 1993.

75. Su, B.Y., F. Kappler, B.S. Szwergold and Brown, T.R.; Identification of a Putative Tumor Marker in Breast and Colon Cancer. Cancer Res. 53 (8): 1751-54, 1993.

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76. Lal, S., Szwergold, B.S., Kappler, F. and Brown, T.R.; Detection of Fructose-3-Phosphokinase Activity in Intact Mammalian Lenses by 31P NMR Spectroscopy. J. Biol. Chem. 268 (11): 7763-67, 1993.

77. Gonen, O., Murphy-Boesch, J., R. Srinvasan, R., Hu, J., Jiang, H., Stoyanova, R. and Brown, T.R.; Simultaneous and Interleaved Multinuclear Chemical Shift Imaging, a Method for Concurrent, Localized Spectroscopy. J. Magn. Reson. Series B, 104(1); 26-33, 1994.

78. Leach, M.O., Arnold, D., Brown, T.R., Charles, H.C., de Certaines, J.D., Evelhoch, J.L., Margulis, A.R., Negendank, W.G., Nelson, S.J., Podo, F., Styles, P., and Shtern, F.; International Workshop on Standardization in Clinical MRS Measurements: Proceedings and Recommendations. Technology & Health Care 2; 217-34, 1994.

79. Graham, R.A., Taylor, A.H. and Brown, T.R.; A Method for Calculating The Distribution of pH in Tissues and A New Source of pH Error From The 31P NMR Spectrum. Am. Journal Physio. 266(2P+2); R638-R645, 1994.

80. Lal, S., Szwergold, B.S., Kappler, F. and Brown, T.R.; Effect of pH on The Bioenergetics of Perfused Porcine Lenses. Current Eye Res. 13(3); 239-242, 1994.

81. Gonen, O., Hu, J., Murphy-Boesch, J., Stoyanova, R. and Brown, T.R.; Dual Interleaved 1H and Proton-Decoupled-31P in vivo Chemical Shift Imaging of Human Brain. Magn. Reson. Med. 32(1); 104-9, 1994.

82. Murphy-Boesch, J., Srinivasan, R., Carvajal L., and Brown, T.R.; Two Configurations of The Four-Ring Birdcage For 1H Imaging and 1H Decoupled 31P Spectroscopy of The Human Head. J. Magn. Reson. B103; 103-114, 1994.

83. McNamara, R, Arias-Mendoza, F. and Brown, T.R.; Investigation of Broad Resonances in 31P NMR Spectra of The Human Brain in vivo. NMR In Biomed. 7(5); 237-242, 1994.

84. Szwergold, B.S., Kappler, F., Moldes, M., Shaller, C. and Brown, T.R.; Characterization of A Phosphonium Analog of Choline as A Probe in 31P NMR Studies of Phospholipid Metabolism. NMR In Biomed. 7(3); 121-127, 1994.

85. Lal, S., Szwergold, B.S., Taylor, A.H., Randall, W.C., Kappler, F., and Brown, T.R.; Production of Fructose and Fructose-3-Phosphate in Maturing Rat Lenses. Invest. Ophthal. ‘Vis. Sci. 36; 969-973, 1995.

86. Gonen, O., Hu, J., Stoyanova, R., Goelman, G., Leigh, J.S. and Brown, T.R.; Hybrid Three-Dimensional (1D Hadamard, 2D Chemical Shift Imaging) Phosphorus Localized Spectroscopy of Phantom and Human Brain. Magn. Reson. Med. 33(3); 300-308, 1995.

87. Jeneson, J.A.L., Westerhoff, H.V., Brown, T.R., Van Echteld, C.J.A. and Berger, R.; Quasi-Linear Relationship Between Gibbs Free Energy of ATP Hydrolysis and Power Output in Human Forearm Muscle. Am. J. of Physiology 37 268: C1474-C1484, 1995.

88. Szwergold, B.S., Lal, S., Taylor, A.H., Kappler, F., Su, B.Y. and Brown, T.R.; 31P NMR Evidence of An Activated Hexose-Monophosphate Shunt in Hyperglycemic Rat Lenses in vivo. Diabetes 44(7); 810-815, 1995.

89. Lal, S., Szwergold, B.S., Taylor, A.H., Randall, W.C., Kappler, F., Wells-Knecht, K., Baynes, J. and Brown, T.R.; Metabolism of Fructose-3-Phosphate in The Diabetic Rat Lens. Arch. Biochem. Biophys. 318(1); 191-199, 1995.

90. Negendank, W.G., Padavic-Shaller, K.A., Li, C.W., Murphy-Boesch, J., Stoyanova, R., Krigel, R.L., Schilder, R.J., Smith, M.R. and Brown, T.R.; Metabolic Characterization of Human Non-Hodgkin's Lymphomas in vivo With The Use of Proton-Decoupled Phosphorus Magnetic Resonance Spectroscopy. Cancer Research 55(15); 3286-3294, 1995.

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91. Szwergold, B.S., Ugurbil, K. and Brown, T.R.; Properties of Fructose-1, 6-Bisphosphate Aldolase From Escherichia Coli; A NMR Analysis. Archives of Biochemistry and Biophysics 317(1); 244-525, 1995.

92. Brown, T.R., Stoyanova, R., Greenberg, T. Srinivasan, R. and Murphy-Boesch, J.; NOE Enhancements and T1 Relaxation Times of Phosphorylated Metabolites in Human Calf Muscle at 1.5 Tesla. Magn. Reson. Med. 33(3); 417-421, 1995.

93. Balaban, R., Bottomley, P., Brown, T.R., Gadian, D., Mountford, C., Radda, G.K., Ross, B.D., Shulman, R.G., Springer, C. and Ugurbil, K.; Advances in Physiological Chemistry By in vivo NMR. Magn. Reson. Med. MRM 34; 289-292, 1995.

94. Stoyanova, R., Kuesel, A.C. and Brown, T.R.; Application of Principal Component Analysis for NMR. J. Magn. Reson. 115; 265-269, 1995.

95. Hu, J., Javaid, T., Arias-Mendoza, F., Liu, Z., McNamara, R. and Brown, T.R.; A Fast, Reliable, Automatic Shimming Procedure Using 1H Chemical-Shift-Imaging Spectroscopy. J. Magn. Reson. B108(3); 213-219, 1995.

96. Kappler, R., Su, B., Szwergold, B.S., Randall, W.C. and Brown, T.R.; Identification of Galactitol 2-Phosphate and Galactitol 3-Phosphate in The Lens of Galactose-Fed Rats. Metabolism 44(12); 1527-1531, 1995.

97. Brown, T.R. and Stoyanova, R.; NMR Spectral Quantitation by Principal Component Analysis II: Determination of Frequency and Phase Shifts. J. Magn. Reson. B112(1); 32-43, 1996.

98. Negendank, W., Li, C.W., Padavic-Shaller, K., Murphy-Boesch, J. and Brown, T.R.; Phospholipid Metabolites In 1H-Decoupled 31P MRS in vivo In Human Cancer: Implications for Experimental Models and Clinical Studies. Anticancer Research 16(3B); 1539-1544, 1996.

99. Aiken N.R., Szwergold, B.S., Kappler, F., Stoyanova, R., Kuessel, A.C., Shaller, C. and Brown, T.R.; Metabolism of Phosphonium Choline by Rat-2 Fibroblasts: Effects of Mitogenic Stimulation Studied Using 31P NMR Spectroscopy. Anticancer Research 16(3B); 1357-1363, 1996.

100. Arias-Mendoza, F., Javaid, T., Stoyanova, R., Brown, T.R. and Gonen, O.; Heteronuclear Multivoxel Spectroscopy of in vivo Human Brain - Two-Dimensional Proton Interleaved With Three-Dimensional H1- Decoupled Phosphorus Chemical Shift Imaging. NMR in Biomed. 9(3); 105-113, 1996.

101. Kuesel, A.C., Stoyanova, R., Aiken, N.R., Li, C.W., Szwergold, B.S., Shaller, C. and Brown, T.R.; Quantitation of Resonances in Biological P-31 NMR Spectra via Principal Component Analysis - Potential and Limitations. NMR in Biomed. 9(3); 93-104, 1996.

102. Li, C.W., Kuesel, A.C., Padavic-Shaller, K.A., Murphy-Boesch, J., Eisenberg, B.L., Schmidt, R.G., Von Roemeling, R.W., Patchefsky, A.S., Brown, T.R. and Negendank, W.G.; Metabolic Characterization of Human Soft Tissue Sarcomas in vivo and in vitro Using Proton-Decoupled Phosphorus Magnetic Resonance Spectroscopy. Cancer Research 56(13); 2964-72, 1996.

103. Negendank, W.G., Sauter, R., Brown, T.R., Evelhoch, J.L., Falini, A., Gotsis, E.D., Heerschap, A., Kamada, K., Lee, B.C., Mengeot, T.A., Stillman, A.E., Terwey, B., Vogl, T.J., Wicklow, K. and Zimmerman, R.A.; Proton Magnetic Resonance Spectroscopy In Patients With Glial Tumors: A Multicenter Study. Journal of Neurosurgery 84(3); 449-58, 1996.

104. Li, C.W., Negendank, W.G., Padavic-Shaller, K.A., O'Dwyer, P.J., Murphy-Boesch, J. and Brown, T.R.; Quantitation of 5-Fluorouracil Catabolism in Human Liver in vivo by 3D-Localized 19F Magnetic Resonance Spectroscopy. Clinical Cancer Research 2(2); 339-45, 1996.

105. Li, C.W., Negendank, W.G., Murphy-Boesch, J., Padavic-Shaller, K. and Brown, T.R.; Molar Quantitation of Hepatic Metabolites in vivo in Proton-Decoupled, Nuclear Overhauser Effect Enhanced 31P NMR Spectra Localized by Three-Dimensional Chemical Shift Imaging. NMR In Biomedicine 9(4); 141-155, 1996.

11


106. Lal, S., Kappler, F., Walker, M., Orchard, T.J., Beisswenger, P.J., Szwergold, B.S. and Brown, T.R.; Quantitation of 3-Deoxyglucosone Levels In Human Plasma. Arch. of Biochem. Biophy. 342(2); 254-260, 1997.

107. Gonen, O., Murphy-Boesch, J., Li, C.W., Padavic-Shaller, K., Negendank, W.G. and Brown, T.R.; Simultaneous 3D NMR Spectroscopy of Proton-Decoupled Fluorine and Phosphorus in Human Liver During 5-Fluorouracil Chemotherapy. Mag. Res. Med. 37(2); 164-9, 1997.

108. Gonen, O., Mohebbi, A., Stoyanova, R. and Brown, T.R.; In vivo Phosphorus Polarization Transfer and Decoupling From Protons in Three-Dimensional Localized Nuclear Magnetic Resonance Spectroscopy of Human Brain. Mag. Res. Med. 37(2); 301-6, 1997.

109. Murphy-Boesch, J., Li, C.W., He, L., Padavic-Shaller, K.A., Negendank, W. and Brown, T.R.; Proton-Decoupled 19F Spectroscopy of 5-FU Catabolites in Human Liver. Mag. Res. Med. 37(3); 321-6, 1997.

110. Street, J.C., Szwergold, B.S., Matei, C., Kappler, F., Mahmood, U., Brown, T.R. and Koutcher, J.A.; Study of The Metabolism of Choline and Phosphatidylcholine in Tumors in vivo Using Phosphonium-Choline. Mag. Res. Med. 38; 769-75, 1997.

111. Lal, S., Randall, W.C., Taylor, A.H., Kappler, F., Walker M. and Brown, T.R..; Fructose-3-Phosphate Production and Polyol Pathway Metabolism in Diabetic Rat Hearts. Metabolism 46(11); 1333-8, 1997.

112. Murphy-Boesch, J., Jiang, H., Stoyanova, R., Brown, T.R.; Quantitation of Phosphorus Metabolites From Chemical Shift Imaging Spectra With Corrections For Point Spread Effects and B1 Inhomogeneity. MRM 39(3); 429-438, 1998.

113. Lal, S., Kappler, F., Walker, M., Orchard, T.J., Beisswenger, Paul J., Szwergold, B.S. and Brown, T.R.; Production and Metabolism of 3-Deoxyglucosone in Humans. The Maillard Reaction in Foods and Medicine. 223; 291-298, 1998.

114. Ochs, M.F., Stoyanova, R.S., Arias-Mendoza, F. and Brown, T.R.; A New Method For Spectral Decomposition Using A Bilinear Bayesian Approach. J. Magn. Reson. 137(1); 161-176, 1999.

115. Patriotis, P.C., Querec, T.D., Gruver, B.N., Brown, T.R. and Patriotis, C.; Array Explorer, a program in Visual Basic for Robust and Accurate Filter cDNA Array Analysis. Biotechniques. 31(4); 862, 864, 866-8, 870, 872, 2001.

116. Stoyanova, R. and Brown, T.R.; NMR Spectral Quantitation by Principal Component Analysis. NMR Biomed. 14 (4); 271-7, 2001.

117. Kappler, F., Schwartz, M.L., Su, B., Tobia, A.M. and Brown, T.R.; DYN 12, A Small Molecular Inhibitor of The Enzyme Amadorase, Lowers Plasma 3-Deoxyglucosone Levels in Diabetic Rats. Diabetes 3(4); 609-616, 2001.

118. Shukla-Dave, A., Poptani, S., Loevner, L., Mancuso, A., Serrai, H., Rosenthal, D.I., Kilger, A.M., Nelson, D.S., Zakin, K.L., Arias-Mendoza, F., Rijpkema, M., Koutcher, J.A., Brown, T.R., Heerschap, A. and Glickson, J.D.; Prediction of Treatment Response of Head and Neck Cancers with P-31 MR Spectroscopy From Pretreatment Relative Phosphomonoester Levels1. Academic Radiology 9(6); 688-694, June 2002.

119. Franks, S.E., Smith, M.R., Arias-Mendoza, F., Shaller, C., Padavic-Shaller, K., Kappler, F., Zhang, Y., Negendank W.G. and Brown, T.R.; Phosphomonoester Concentrations Differ Between Chronic Lymphocytic Leukemia Cells and Normal Human Lymphocytes. Leuk Res. 26(10); 919-26, 2002.

120. Stoyanova R. and Brown, T.R.; NMR Spectral Quantitation by Principal Component Analysis. III. A Generalized Procedure for Determination of Lineshape Variations. J. Magn. Reson. 154(2); 163-75, 2002.

121. Brown, T.R., Su, B. Brown, K.A., Schwartz, M.A., Tobia, A.M. and Kapler, F.; Modulation of in vivo 3-Deoxyglucosone Levels. Biomedical Society Transactions 31(PT 6); 1433-1437, December 2003.

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122. Sajda, P., Du, S., Parra, L., Stoyanova, R. and Brown, T.R.; Recovery of Constituent Spectra in 3D Chemical Shift Imaging Using Non-Negative Matrix Factorization. 4 th International Symposium on Independent Component Analysis and Blind Signal Separation (ICA2003); 71-76, 2003.

123. Arias-Mendoza, F., Zakian, K., Schwartz, A., Howe, F.A., Koutcher, J.A., Leach, M.O., Griffiths, J.R., Heersekap, A., Glickson, J.D., Nelson, S.J., Evelhoch, J.L., Charles, H.C. and Brown, T.R.; Methodological Standardization For A Multi-institutional in vivo Trial of Localized 31 PMR Spectroscopy in Human Cancer Research. In Vivo and Normal Volunteer Studies. NMR Biomed. 17(6); 382-391, 2004.

124. Arias-Mendoza F., Smith M.R. and Brown, T.R.; Predicting Treatment Response in Non-Hodgkin's Lymphoma From The Pretreatment Tumor Content of Phosphoethanolamine Plus Phosphocholine. Academic Radiology 11(4); 368-376, 2004.

125. Stoyanova, R., Querec, T.D., Brown, T.R. and Patriotis, C.; Normalization of Single Channel DNA Arrays by Principal Component Analysis. Bioinformatics 20(11); 1772-1784, March 2004.

126. Stoyanova, R., Nicholson, J.K., Lindon, J.C. and Brown, T.R.; A New Approach to Sample Classification based on Bayesian Spectral Decomposition of Metabonomic NMR Data Sets. Analytical Chemistry 76(13); 3666-3674, July 2004.

127. Arias-Mendoza, F. and Brown, T.R.; In vivo Measurement of Phosphorous Markers of Disease. Disease Markers 19(2-3); 49-68, 2003-2004.

128. Habeck, C., Rakitin, B.C., Moeller, J., Scarmeas N. ,Zarahn, E., Brown, T.R. and Stern, Y.; An Event-Related fMRI Study of The Neurobehavioral Impact of Sleep Deprivation on Performance of A Delayed-Match-To-Sample Task. Cognitive Brain Research. 18; 306–321, 2004.

129. Stoyanova, R., Nicholls, A.W., Nicholson, J.K., Lindon, J.C. and Brown, T.R.; Automatic Alignment of Indivuduals Peaks in Large High Resolution Spectral Data Sets. J. Magn. Reson. 170 (2); 329-335, 2004.

130. Robinson, J.N., Cleary-Goldman, J., Arias-Mendoza, F., Cruz-Lobo, J., Tempany, C., Mulkern, R.V., Feinburg, B.B. and Brown, T.R..; Detection of Fetal Lactate with Two Dimensional-Localized Proton Magnetic Resonance Spectroscopy. American College of Obstetricians & Gynecologists 104; 1208-1210, 2004.

131. Stoyanova, R., Nichelson, J.K., Lindon, J.C. and Brown, T.R.; Sample Classification Based on Bayesian Spectral Decomposition of Metabonomic NMR Data Sets. Analytical Chemistry 76; 3666-3674, 2004.

132. Stoyanova, R., Nicholls, A.W., Nicholson, J.K., Lindon, J.C. and Brown, T.R.; Automatic alignment of individual peaks in large high-resolution spectral data sets. J Magn Reson. Oct; 170 (2); 329-35, 2004.

133. Sajda, P., Du, S., Brown, T.R., Stoyanova, R., Shungu, D.C., Mao, X. and Parra, L.C.; Non-Negative Matrix Factorization for Rapid Recovery of Constituent Spectra in Magnetic Resonance Chemical Shift Imaging of The Brain. IEEE Trans Med Imaging 23(12); 1453-1465, December 2004.

134. Wright, C.B., Paik, M.C., Brown, T.R., Stabler, S.P., Allen, R.H., Sacco, R.L. and DeCarli, C.; Total Homocysteine Is Associated With White Matter Hyperintensity Volume - The Northern Manhattan Study. Stroke 36(6); 1207-1211, June 2005.

135. Brown, T.R., Ochs, M.F., Rooney, W.D., Stoyanova, R., Li, X. and Speinger, C.S.; Bayesian Image Decomposition Applied to Relaxographic Imaging. Inter. J. Imag. Sys. Tech. 15; 2-9, 2005.

136. Habeck, C., Rakitin, B.C., Moeller, J., Scarmeas, N., Zarahn, E., Brown, T.R. and Stern, Y.; An event-related fMRI study of the neural networks underlying the encoding, maintenance, and retrieval phase in a delayed-match-to-sample task. Brain Res Cogn Brain Res. 23(2-3); 207-20, May 2005.

137. Sheth, S., Tang, H., Jensen, J.H., Altmann, K., Prakash, A., Printz, B.F., Hordof, A.J., Tosti, C.L., Azabagic, A., Swaminathan, S., Brown, T.R., Olivieri, N.F. and Brittenham, G.M.; Methods For Noninvasive

13


Measurement of Tissue Iron in Cooley’s Anemia. Ann. N.Y. Acad. Sci. 1054; 358-372, 2005.

138. Coon, A. L, Arias-Mendoza, F., Colby, G.P., Cruz-Lobo, J., Mocco, J., Mack, W.J., Komotar, R.J., Brown, T.R. and Connolly Jr., E.S.; Correlation of Cerebral Metabolites With Functional Outcome In Experimental Primate Stroke Using in Vivo 1H-Magnetic Resonance Spectroscopy. AJNR Am J. Neuroradiol. 27; 1053-58, May 2006.

139. Moreno, H., Hua, F., Brown, T.R. and Small, S.A.; An MRI Technique for Mapping Cerebral Blood Volume Longitudinally in Mice. NMR in Biomed 19 (5); 535-43, August 2006.

140. Habeck, C., Hilton, H.J., Zarahn, E., Brown, T. and Stern, Y.; An Event-Related fMRI Study of The Neural Networks Underlying Repetition Suppression and Reaction Time Priming in Implicit Visual Memory. Brain Research 1075(1); 133-141, 2006.

141. Arias-Mendoza, F., Payne, G.S., Zakian, K.L., Schwartz, A.J., Stubbs, M., Stoyanova, R., Ballon, D., Howe, F.A., Koutcher, J.A., Leach, M.O., Griffiths, J.R., Heerschap, A., Glickson, J.D., Nelson, S.J., Evelhoch, J.L., Charles, H.C. and Brown, T.R.; The Cooperative Group on MRS Applications in Cancer; In Vivo 31P MR Spectral Patterns and Reproducibility in Cancer Patients Studied in a Multi-Institutional Trial. NMR in Biomedicine. 19; 504-512, 2006.

142. Zhao, Q., Stoyanova, R., Du, S., Sajda, P. and Brown, T.R.; HiRes - A Tool for Comprehensive Assessment and Interpretation of Metabolomic Data. Bioinformatics 22(20); 2562-2564, August 2006.

143. Tabert, M.H., Steffener, J., Albers, M.W., Kern, D.W., Michael, M., Tang, H., Brown, T.R. and Devanand, D.P.; Validation and Optimization of Statistical Approaches for Modeling Odorant-Induced fMRI Signal changes in Olfactory-Related Brain Areas. NeuroImage 34(4): 1375-90, February 2007.

144. Pereira, A.C., Huddleston, D.E., Brickman, A.M., Sosunov, A.A., Hen, R., McKhann, G.M., Sloan, R., Gage, F.H., Brown, T.R. and Small, S.A; An In Vivo Correlate of Exercise-Induced Neurogenesis in The Adult Dentate Gyrus. Proc Acad Sci 104(13); 5638-5643, March 2007.

145. Choi, J.J., Pernot, M., Brown, T.R., Small, S.A. and Konofagou, E.E.; Spatio-Tempral Analysis of Molecular Delivery through the Blood-Brain Barrier Using Focused Ultrasound. Physics in Medicine and Biology 52; 5509-5530, August 2007.

146. Moreno, H., Wu, W.E., Lee, T., Brickman, A., Mayeux, R., Brown, T.R. and Small, S.A; Imaging the Abeta-Related Neurotoxicity of Alzheimer Disease. Archives of Neurology 64(10); 1467-77, October 2007.

147. Asllani, I., Habeck, C., Scarmeas, N., Borogovac, A., Brown, T.R. and Stern, Y.; Multivariate and Univariate Analysis of Continuous Arterial Spin Labeling Perfusion MRI in Alzheimer's Disease. Journal of Cerebral Blood Flow & Metabolism 28, 725-736, 2008.

148. Prabhakaran, S., Wright, C.B., Yoshita, M., Delapaz, R., Brown, T.R., DeCarli, C. and Sacco, R.L.; Prevalence and Determinants of Subclinical Brain Infarction: The Northern Manhattan Study. Neurology 70(6); 425-30, 2008.

149. Sigmund, E.E., Cho, H., Chen, P., Byrnes, S., Song, Y.Q., Guo, X.E. and Brown, T.R.; Diffusion-Based MR Methods for bone Structure and Evolution. Magnetic Resonance in Medicine 59; 28-39, January 2008.

150. Asllani, I., Borogovac, A., Wright, C., Sacco, R., Brown, T.R. and Zarahn E.; An Investigation of Statistical Power for Continuous Arterial Spin Labeling Imaging at 1.5T. NeuroImage 39(3); 1246-1256, February 2008.

151. Wright, C.B., Festa, J.R., Paik, M.C., Schmiedigen, A., Brown, T.R., Yoshita, M., DeCarli, C., Sacco, R. and Stern, Y.; White Matter Hyperintensities and Subclinical Infarction. Associations with Psychomotor Speed and Cognitive Flexibility. Stroke 39; 800-805, February 2008.

152. Hultman K.L,, Raffo A.J., Grzenda A.L., Harris P.E., Brown T.R., O'Brien S., Magnetic resonance imaging of major histocompatibility class II expression in the renal medulla using immunotargeted superparamagnetic iron

14


oxide nanoparticles., ACS Nano., 2(3):477-84, March 2008

153. Stern, Y., Zarahn, E., Habeck, C., Holtzer, R., Rakitin, B.C., Kumar, A., Flynn, J., Steffener, J. and Brown, T.R.; A Common Neural Network for Cognitive Reserve in Verbal and Object Working Memory in Young but Not Old. Cerebral Cortex 18(4); 959-967, April 2008.

154. Choi, J.J., Wang, S., Brown, T.R., Small, S.A., Duff, K.E., Konofagou, E.E., Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasound, Ultrasound Imaging, 30(3):189-200 July 2008

155. Brickman A.M., Schupf N., Manly J.J., Luchsinger J.A., Andrews H., Tang M.X., Reitz C., Small S.A., Mayeux R., DeCarli C., Brown T.R., Brain morphology in older African Americans, Caribbean Hispanics, and Whites from northern Manhattan., Arch Neurol. Aug;65(8):1053-61, 2008.

156. Lee, W.N., Qian, Z.., Tosti, C.L., Brown, T.R,, Metaxas, D.N., Konofagou, E.E.., Preliminary validation of angle-independent myocardial elastography using MR tagging in a clinical setting, Ultrasound Med. Biol., Dec;34(12):1980-97, 2008

157. Asllani, I., Borogovac, A., Brown T.R., Regression algorithm correcting for partial volume effects in arterial spin labeling MRI., Magn Reson Med. 60(6):1362-71, December 2008.

158. Devanand, D.P., Tabert, M.H., Cuasay, K., Manly, J.J., Schupf, N., Brickman, A.M., Andrews, H., Brown, T.R., Decarli, C., Mayeux, R., Olfactory identification deficits and MCI in a multi-ethnic elderly community sample., Neurobiol Aging. Oct 27 [Epub ahead of print] 2008.

159. Louis, E.D., Brickman, A.M., DeCarli, C., Small, S.A., Marder, K., Schupf, N., Brown, T.R., Quantitative brain measurements in community-dwelling elderly persons with mild parkinsonian signs, Arch Neurol., 65(12):1649-54. December 2008.

160. Duan, Y., Peterson, B.S., Liu, F., Brown, T.R., Ibrahim, T.S., Kangarlu, A., Computational and experimental optimization of a double-tuned (1)H/(31)P four-ring birdcage head coil for MRS at 3T, J Magn Reson Imaging. 29(1):13-22, January 2009.

161. Friedman D., Goldman R., Stern Y., Brown T.R., The brain's orienting response: An event-related functional magnetic resonance imaging investigation., Hum Brain Mapp., 30(4):1144-54, 2009.

162. Asllani, I., Habeck, C., Borogovac, A., Brown, T.R., Brickman, A.M., Stern, Y., Separating function from structure in perfusion imaging of the aging brain, Hum Brain Mapp., 30(9):2927-35, 2009.

163. Dyrholm, M., Goldman, R., Sajda, P., Brown, T.R., Removal of BCG artifacts using a non-Kirchhoffian overcomplete representation, IEEE Trans Biomed Eng., Feb;56(2):200-4, 2009.

164. Reitz, C., Schupf, N., Luchsinger, J.A., Brickman, A.M., Manly, J.J., Andrews, H., Tang, M.X., Decarli, C., Brown, T.R., Mayeux, R., Validity of Self-reported Stroke in Elderly African Americans, Caribbean Hispanics, and Whites, Arch Neurol. Jul;66(7):834-40, 2009

165. Brickman, A.M., Zahra, A., Muraskin, J., Steffener, J., Holland, C.M., Habeck, C., Borogovac, A,, Ramos, M.A., Brown, T.R., Asllani, I., Stern, Y., Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging, Psychiatry Res. May 15;172(2):117-20, 2009.

166. Ooi, M.B., Krueger S., Thomas, W.J., Swaminathan, S.V., Brown, T.R., Prospective real-time correction for arbitrary head motion using active markers, Magn. Reson. Med., Magn Reson Med. 2009 Oct;62(4):943-54..

167. Goldman, R.I., Wei, C.Y., Philiastides, M.G., Gerson, A.D., Friedman, D., Brown, T.R., Sajda, P., Single-trial discrimination for integrating simultaneous EEG and fMRI: identifying cortical areas contributing to trial-to-trial variability in the auditory oddball task, Neuroimage, Aug 1;47(1):136-47. 2009

168. 15


Brickman, A.M., Siedlecki, K.L., Muraskin, J., Manly, J.J., Luchsinger, J.A., Yeung, L.K., Brown, T.R., Decarli, C., Stern, Y., White matter hyperintensities and cognition: Testing the reserve hypothesis, Neurobiol Aging. 2009 Nov 17. [Epub ahead of print]

169. Reitz, C., Brickman, A.M., Brown, T.R., Manly, J.J., DeCarli, C., Small, S.A., Mayeux, R., Linking hippocampal structure and function to memory performance in an aging population., Arch Neurol. 2009 Nov;66(11):1385-92.

170. Looareesuwan, S., Laothamatas, J., Brown, T.R., Brittenham, G.M., Cerebral malaria: a new way forward with magnetic resonance imaging (MRI)., Am J Trop Med Hyg. 2009 Oct;81(4):545-7.

171. Wright, C.B., Moon, Y., Paik, M.C., Brown, T.R., Rabbani, L., Yoshita, M., DeCarli, C., Sacco, R., Elkind, M.S., Inflammatory biomarkers of vascular risk as correlates of leukoariosis., Stroke. 2009 Nov;40(11):3466-71.

172. Luchsinger, J.A., Brickman, A.M., Reitz, C., Cho, S.J., Schupf, N., Manly, J.J., Tang, M.X., Small, S.A., Mayeux, R., DeCarli, C., Brown, T.R., Subclinical cerebrovascular disease in mild cognitive impairment., Neurology. 2009 Aug 11;73(6):450-6.

173. Guo, H., Au, W.Y., Cheung, J.S., Kim, D., Jensen, J.H., Khong, P.L., Chan, Q., Chan, K.C., Tosti, C., Tang, H., Brown, T.R., Lam, W.W., Ha, S.Y., Brittenham, G.M., Wu, E.X., Myocardial T2 quantitation in patients with iron overload at 3 Tesla., J Magn Reson Imaging. 2009 Aug;30(2):394-400.

174. Reitz C, Brickman AM, Brown TR, Manly J, DeCarli C, Small SA, Mayeux R., Linking hippocampal structure and function to memory performance in an aging population., Arch Neurol. 2009 Nov;66(11):1385-92.

175. Looareesuwan S, Laothamatas J, Brown TR, Brittenham GM., Cerebral malaria: a new way forward with magnetic resonance imaging (MRI)., Am J Trop Med Hyg. 2009 Oct;81(4):545-7.

176. Wright CB, Moon Y, Paik MC, Brown TR, Rabbani L, Yoshita M, DeCarli C, Sacco R, Elkind MS., Inflammatory biomarkers of vascular risk as correlates of leukoariosis., Stroke. 2009 Nov;40(11):3466-71.

177. Luchsinger JA, Brickman AM, Reitz C, Cho SJ, Schupf N, Manly JJ, Tang MX, Small SA, Mayeux R, DeCarli C, Brown TR., Subclinical cerebrovascular disease in mild cognitive impairment., Neurology. 2009 Aug 11;73(6):450-6.

178. Jensen JH, Tang H, Tosti CL, Swaminathan SV, Nunez A, Hultman K, Szulc KU, Wu EX, Kim D, Sheth S, Brown TR, Brittenham GM, Separate MRI quantification of dispersed (ferritin-like) and aggregated (hemosiderin-like) storage iron, Magn Reson Med. 2010 May;63(5):1201-9.

179. Brickman AM, Reitz C, Luchsinger JA, Manly JJ, Schupf N, Muraskin J, DeCarli C, Brown TR, Mayeux R, Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohort, Arch Neurol. 2010 May;67(5):564-9.

180. Wu EX, Kim D, Tosti CL, Tang H, Jensen JH, Cheung JS, Feng L, Au WY, Ha SY, Sheth SS, Brown TR, Brittenham GM., Magnetic resonance assessment of iron overload by separate measurement of tissue ferritin and hemosiderin iron, Ann N Y Acad Sci. Aug;1202:115-22, 2010.

Editorials, Reviews, Chapters:

1. Shulman, R.G., Navon, G., Ogawa, S., Yamane, T., Brown, T.R., Ugurbil, K., Glynn, P. and Rottenberg, H.; 31P High Resolution NMR Studies of Bioenergetics in e. coli. Bioenergetics of Membranes (ed. L. Packer et al.) pp. 471-476, North Holland, 1977.

2. Shulman, R.G., Brown, T.R., den Hollander, J.H. and Ugurbil, K.; 13C NMR Studies of Glycolysis in Suspensions of Escherichia Coli Cells. Transport by Proteins (ed. G. Blauer and H. Sund) Gruyter, New York, 1978. 16


3. Ugurbil, K., Shulman, R.G. and Brown, T.R.; High-Resolution 31P And 13C Nuclear Magnetic Resonance Studies Of Escherichia Coli Cells in vivo. Biological Applications of Magnetic Resonance (ed. R.G. Shulman) pp. 537-589, Academic, New York, 1979.

4. Kushmerick, M.J., Meyer, R.A. and Brown, T.R.; Phosphorus NMR Spectroscopy of Cat Biceps and Soleus Muscles. Advances in Experimental Medicine and Biology, 159:303-25, 1983.

5. Brown, T.R. and Ugurbil, K.; Nuclear Magnetic Resonance. Structural and Resonance Techniques in Biological Research (ed. D.L. Rousseau), Academic, New York, 1984.

6. Brown, T.R.; Applications of Nuclear Magnetic Resonance To The Study Of Parasitic Disease. In, "Interaction of Parasitic Diseases and Nutrition," pp 121-127 (eds. C. Chagas and G.T. Keusch). Pontifical Academy of Sciences Press, Vatican City, 1986.

7. Brown, T.R.; "Techniques for NMR Spectroscopic Localization." Magnetic Resonance in Cancer (eds. P.S. Allen, D.P.J. Boisvert, B.C. Lentle), Pergamon Press, New York, 1986.

8. Brown, T.R.; "The Predictive Possibilities for NMR in Oncology." Prediction of Tumor Treatment Response, (eds. J.D. Chapman, L.J. Peters and H.R. Withers), Pergamon Press, New York, pp 297-306, 1989.

9. Robinson, J.N., Goldman, J.C., Arias-Mendoza, F., Cruz-Lobo, J., Tempany, C., Mukern, R.V., Feinberg, B.B. and Brown, T.R.; Detection of Fetal Lactate With Two Dimensional-Localized Proton Magnetic Resonance Spectroscopy. Obstetrics and Gynecology, 104: 1208-1210, 2004.

10. Brown, T.R.; "In vivo NMR Observation of Cerebral Metabolism". Cerebral Mechanisms and Basic Ischemia, (eds. A. Hartmann, F. Yatsu, and W. Kuschinsky), Springer-Verlag Berlin Heidelberg, pp 91-110, 1994.

11. Brown, T.R.; Chemical Shift Imaging: Spectroscopic Studies. Encyclopedia of Nuclear Magnetic Resonance (Eds. D.M. Grant, R.K. Harris, I.R. Young), John Wiley & Sons, 1261-1272, 1995.

12. Stoyanova, R., Arias-Mendoza, F. and Brown, T.R.; Making Multidimensional Spectroscopy Practical: Application of Principal Component analysis to CSI Data. In high-power gradient MR-imaging: Advances In MRI II. (M.Oudkerk, and R.R. Edelman, Eds.) Blackwell Science Ltd., London, 253-356, 1997.

13. Arias-Mendoza, F., Elkashef, A., Stoyanova, R., Gold, J., Wyatt, J. and Brown, T.R., Coenzyme Q10 Effect on Cognitive Functions And Bioenergetics In Schizophrenia: A Brain Localized 31P Magnetic Resonance Study. In high power gradient MR-Imaging: advances in MRI II. (M. Oudkerk, and R.R. Edelman, Eds.) Blackwell Science Ltd., London 257-262, 1997.

14. Kappler F., Djafroudi, S., Kayser, H., Su B., Lal S., Randall, W.C., Walker, M.A., Taylor, A., Szwergp;d. B.S. Erbersdobler, H. and Brown, T.R.; Metabolism of Fructoselysine in The Kidney. In Proceedings of The Sixth International Maillard Symposium, London, 1997. O’Brien, J. Nursen, H.E., Crabbe, M.J.C., Ames, J.M., Eds. Cambridge, U.K., The Royal Society of Chemistry pp 415.

15. Ochs, M.F., Stoyanova, R., Brown, T.R., Rooney, W.D. and Springer, C.S; A Bayesian Markov Chain Monte Carlo Solution of the Bilinear Problem, in Bayesian Interference and Maximum Entropy Methods in Science and Engineering, Editors: J.T.Rychert, G.J. Erikson and C.R. Smith, AIP Conference Proceedings, V. 567, Melville, New York, 2001.

Abstracts Since 1990 (Selected):

1. Taylor, J.S., Vigneron, D.B., Nelson, S.J., Murphy-Boesch, J., Stoyanova, R., Kessler, H.B., Curran, W., Coia, L. and Brown, T.R.; Studies of Cytosolic Mg and Free ATP Concentration in Normal Human Brain and Brain Tumor. Proceedings of the Society of Magnetic Resonance in Medicine Annual Meeting, 1990.

2. Vigneron, D.B., Taylor, J.S., Murphy-Boesch, J., Kessler, H.B., Curran, W., Coia, L. and Brown, T.R.; Studies of Metastatic Brain Tumor Using Three Dimensional 31P Metabolite Imaging. Proceedings of The Society of Magnetic Resonance in Medicine Annual Meeting, 1990.

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3. Nelson, S.J., Taylor, J.S., Vigneron, D.B., Murphy-Boesch, J. and Brown, T.R.; Imaging 31P Metabolites in The Human Arm at Rest and During Exercise. Proceedings of The Society of Magnetic Resonance in Medicine Annual Meeting, 1990.

4. Vigneron, D.B., Taylor, J.S., Nelson, S.J., Kessler, H.B., Murphy-Boesch, J. and Brown, T.R.; 31P NMR Studies of Sarcomas Using 1-D and 3-D CSI and Metabolite Imaging. Proceedings of The Society of Magnetic Resonance in Medicine Annual Meeting, 1990.

5. Jeneson, J.A.L., Nelson, S.J., Taylor, J.S., Willard, T.S., Vigneron, D.B., Murphy-Boesch, J. and Brown, T.R.; 1H and 31P NMR Imaging of Anatomical Compartments Within The Finger Flexor Muscles of The Human Forearm. Proceedings of The Society of Magnetic Resonance in Medicine Annual Meeting, 1990.

6. Nelson, S.J., Vigneron, D.B., Taylor, J.S., Murphy-Boesch, J., Kosinski, E., Scherphier, J.T. and Brown, T.R.; Analysis and Interpretation of 31P Metabolite Images Obtained from 2-D and 3-D Chemical Shift Imaging Data. Proceedings of The Society of Magnetic Resonance in Medicine Annual Meeting, 1990.

7. Murphy-Boesch, J., Srinivasan, R., Stoyanova, R., Willard, T. and Brown, T.R.; Sensitivity of 1H Decoupled 31P CSI Spectra of The Human Brain for Spatial Resolutions from 64 to 8 cc. Proceedings of The Society of Magnetic Resonance in Medicine Annual Meeting, 1991.

8. Brown, T.R., Stoyanova, R., Srinivasan, R., Willard, T., Kosinski, E. and Murphy-Boesch, J.; Proton Decoupled T1's and NOE Enhancements of Phosphorus Metabolites in The Calf. Proceedings of The Society of Magnetic Resonance in Medicine Annual Meeting, 1991.

9. Taylor, J.S., Vigneron, D., Murphy-Boesch, J., Nelson, S.J., Stoyanova, R., Willard, T., Kellser, H.B., Lanciano, R., Curran, W., Coia, L. and Brown, T.R.; MRI/31P 3-D CSI Clinical Examination of Brain Tumor Patients Undergoing Therapy. Proceedings of the Society of Magnetic Resonance in Medicine Annual Meeting, 1991.

10. Graham, R.A., Brown, T.R. and Meyer, R.A.; The Effect of Perfusate pH on Tumor pH in The Isolated Perfused Morris Hepatoma 7777. Proceedings of the Society of Magnetic Resonance in Medicine Annual Meeting, 1991.

11. Murphy-Boesch, J., Srinivasan, R. and Brown, T.R.; A Dual Tuned Four-Ring Birdcage for 1H Decoupled 31P Spectroscopy of the Human Head at 1.5 Tesla. Proceedings of The Society of Magnetic Resonance in Medicine Annual Meeting, 1991.

12. Taylor, J.S., Vigneron, D.B. and Brown, T.R.; Evaluation of MIMSTATS as a Technique for Interpretation of 31P Metabolite Images. Proceedings of the Society of Magnetic Resonance in Medicine Annual Meeting, 1991.

13. Murphy-Boesch, J., Srinivasan, R., Willard, T., Stoyanova, R., Padavic-Shaller, K., Arias-Mendoza, F., Krigel, R.L., Schilder, R.J., Negendank, W.G. and Brown, T.R.; 1H-Decoupled, 3-D CSI Localized 31P Spectra of Non-Hodgkin's Lymphoma. Proceedings of the Society of Magnetic Resonance in Medicine Annual Meeting, 1992.

14. Srinivasan, R., Arias-Mendoza, F., Murphy-Boesch, J., Stoyanova, R., Willard, T., Negendank, W. and Brown, T.R.; Proton Decoupled 31P CSI of Human Brain in a Rampable Magnet at 2.0 Tesla. Proceedings of The Society of Magnetic Resonance in Medicine Annual Meeting, 1992.

15. Arias-Mendoza, F., Taylor, A.H., Graham, R.A., Srinivasan, R., Stoyanova, R., Murphy-Boesch, J. and Brown, T.R.; Assessment of Tumor Viability in Morris Hepatomas in Situ by Proton MRI and Phosphorus CSI. Proceedings of the Society of Magnetic Resonance in Medicine Annual Meeting, 1992.

16. Hu, J., Gonen, O. and Brown, T.R.; 3-D Proton CSI of Human Brain without Echo. Proceedings of The Society of Magnetic Resonance in Medicine Annual Meeting, 1992.

17. Stoyanova, R. and Brown, T.R.; Automatic Analysis of Chemical Shifts in Multi-Dimensional CSI. Proceedings of the Society of Magnetic Resonance in Medicine Annual Meeting, 1992.

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18. Gonen, O., Hu, J., Stoyanova, R., Goelman, G., Leigh, J.S. and Brown, T.R.; Hybrid, Three Dimensional (1D-Hadamard, 2D-CSI), Phosphorus Localized Spectroscopy of a Human Brain. Proceedings of The Society of Magnetic Resonance in Medicine Annual Meeting, 1993.

19. Negendank, W., Murphy-Boesch, J., Padavic-Shaller, K., Srinivasan, R., Stoyanova, R., Greenberg, T., Krigel, R., Schilder, R., Schmidt, R. and Brown, T.R.; Resolution of Phospholipid Metabolites In Human Cancers in vivo 1H-Decoupling of 31P Spectra Localized by 3-D CSI. Proceedings of the Society of Magnetic Resonance in Medicine Annual Meeting, 1993.

20. Arias-Mendoza, F., Greenberg, T., Stoyanova, R., Ottery, F. and Brown, T.R.; Brain [Mg] in Cancer Cachexia. Proceedings of The Society of Magnetic Resonance in Medicine Annual Meeting, 1993.

21. Gonen, O., Hu, J., Murphy-Boesch, J., Srinivasan, R., Stoyanova, R., Jiang, H. and Brown, T.R.; Interleaved Heteronuclear (1H-31P) 2-D CSI of in vivo Human Brain. Proceedings of the Society of Magnetic Resonance in Medicine Annual Meeting, 1993.

22. McNamara, R., Arias-Mendoza, F. and Brown, T.R.; Investigation of 31P NMR Broad Resonance of The Human Head in vivo. Proceedings of the Society of Magnetic Resonance in Medicine Annual Meeting, 1993.

23. Von Kienlin, M., Hu, J., Jiang, H., Murphy-Boesch, J., Stoyanova, R. and Brown, T.R.; Optimized Localized Spectroscopy of Arbitrary Volumes on a Clinical MR Instrument. Proceedings of the Society of Magnetic Resonance in Medicine Annual Meeting, 1993.

24. Negendank, W., Murphy-Boesch, J., Padavic-Shaller, K., Li, C.W., Stoyanova, R., Krigel, R., Schilder, R., Smith, M. and Brown, T.R.; Phosphomonoester Changes and Treatment Response in Non-Hodgkin’s Lymphomas. Proceedings of the Society of Magnetic Resonance Annual Meeting, 1994.

25. Li, C.W., Padavic-Shaller, K., Murphy-Boesch, J., Negendank, W.G. and Brown, T.R.; Proton-Decoupled 31P in vivo CSI of The Human Liver: Normal Variations. Proceedings of the Society of Magnetic Resonance Annual Meeting, 1994.

26. Negendank, W., Scher, R., Shaer, A., Padavic-Shaller, K., Scuti, C., Goldstein, L., Kessler, H. and Brown, T.R.; Bone Marrow MRI to Assess Metastatic Breast Cancer. Proceedings of the Society of Magnetic Resonance Annual Meeting, 1994.

27. Liu, Z., Javaid, T., Hu, J. and Brown, T.R.; CSI-Autoshim Procedures for Body and Surface Coil. Proceedings of The Society of Magnetic Resonance Annual Meeting, 1994.

28. Stoyanova, R., Kuesel, A.C. and Brown, T.R.; Quantitation of CSI by Principal Component Analysis. Proceedings of The Society of Magnetic Resonance Annual Meeting, 1994.

29. Gonen, O., McNamara, R., Stoyanova, R. and Brown, T.R.; T1 Measurement at Constant TR and Variable Nutation Angles in 31P 3-D CSI. Proceedings of the Society of Magnetic Resonance Annual Meeting, 1994.

30. Li, C.W., Padavic-Shaller, K., Murphy-Boesch, J., Negendank, W.G. and Brown, T.R., Phospholipid Saturated, Proton-Decoupled 31P in vivo CSI of The Human Liver. Proceedings of the Society of Magnetic Resonance Annual Meeting, 1994.

31. Negendank, W., Sauter, R., Brown, T.R., Evelhoch, J., Falini, A., Gotsis, E., Heerschap, A., Kamada, K., Lee, B., Mengeot, M., Moser, E., Padavic-Shaller, K., Sanders, J., Spraggins, T., Stillman, A., Terwey, B., Vogl, T., Wicklow, K. and Zimmerman, R.; Intratumoral Lipids and Lactate in 1H MRS in vivo In Astrocytic Tumors. Proceedings of the Society of Magnetic Resonance Annual Meeting, 1994.

32. Li, C.W., Negendank, W., O'Dwyer, P., Padavic-Shaller, K., Murphy-Boesch, J. and Brown, T.R.; MRI-Directed, 3-D-CSI Localized 19F MRS of 5-Fluorouracil Catabolism in Human Liver. Proceedings of The Society of Magnetic Resonance Annual Meeting, 1994.

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33. Brown, T.R., Stoyanova, R. and Kuesel, A.; NMR Spectral Analysis by PCI. Proceedings of The Experimental NMR Conference, 1995.

34. Li, C.W., Padavic-Shaller, K., O'Dwyer, P., Murphy-Boesch, J., Brown, T.R. and Negendank, W.; Quantitation of Hepatic 5-FU Catabolism in vivo Using 19F NMR. Proceedings of the American Association in Cancer Research Annual Meeting, 1995.

35. Negendank, W., Padavic-Shaller, K., Murphy-Boesch, J., Smith, M.R., Schilder, R.J. and Brown, T.R.; Phospholipid Metabolites in Non-Hodgkin's Lymphomas (NHL) Studied in vivo with 31P NMR. Proceedings of The American Association in Cancer Research Annual Meeting, 1995.

36. Shedd, S.F., Smith, M.R., Shaller, C., Brown, T.R. and Negendank, W.G.; Ethanolamine Modulation of Phospholipid Metabolite Levels in Human B-Cell Malignancies. Proceedings of the American Association in Cancer Research Annual Meeting, 1995.

37. Aiken, N.R., Szwergold, B.S., Kappler, F., Stoyanova, R., Kuesel, A.C., Shaller, C. and Brown, T.R.; 31P NMR Investigation of the Effect of Serum on the Metabolism of The Choline Analogue Phosphonium Choline. Proceedings of the Conference in Anticancer Research, 1995.

38. Negendank, W., Li, C.W., Padavic-Sheller, K., Murphy-Boesch, J. and Brown, T.R.; Phospholipid Metabolites in 1H-Decoupled 31P MRS in vivo in Human Cancer: Implication for Experimental Models. Proceedings of The Conference in Anticancer Research, 1995.

39. Gonen, O., Mohebbi, A. and Brown, T.R.; In vivo Brain 31P Signal Enhancement by Polarization Transfer and Decoupling from 1H en 3D Localized NMR. Proceedings of the Radiological Society of North America Annual Meeting, 1995.

40. Li, C.W., Negendank, W., Murphy-Boesch, J., Padavic-Shaller, K. and Brown, T.R., Molar Quantitation of Metabolites in 1H-Decoupled, 31P MRS of Liver. Proceedings of the Radiological Society of North America Annual Meeting, 1995.

41. Li, C.W., Negendank, W., Padavic-Sheller, K., Murphy-Boesch, J., O'Dwyer, P. and Brown, T.R.; Molar Quantitation of 5-FU Catabolism in vivo Using 3D-CSI Localized 19F MRS. Proceedings of The Radiological Society of North America Annual Meeting, 1995.

42. Brown, T.R., Stoyanova, R. and Arias-Mendoza, F.; Application of PCA to Spectroscopy: A Novel Approach for Identification of Features in CSI Data. Proceedings of the Radiological Society of North America Annual Meeting, 1995.

43. Negendank, W., Padavic-Sheller, K., Scher, R. and Brown, T.R.; Bone Marrow MRI to Assess Treatment Response in Metastatic Breast Cancer. Proceedings of the Radiological Society of North America Annual Meeting, 1995.

44. Arias-Mendoza, F., Elkashef, A., Stoyanova, R., Gold, J., Wyatt, R.J. and Brown, T.R.; CoQ10 Effect on Cognitive Functions and Bioenergetics in Schizophrenia: An Anatomically Localized 31P MRS Study. Proceedings of the Radiological Society of North America Annual Meeting, 1995.

45. Kuesel, A.C., Shaller, C., Padavic-Shaller, K. and Brown, T.R.; Comparison of Phospholipid Metabolite Patterns in Breast Cancer and Sarcoma, Determined by 31P NMR. Proceedings of the American Association in Cancer Research Annual Meeting, 1996.

46. Negendank, W., Padavic-Shaller, K., Brown, T.R. and Li, C.W.; Phosphomonoester Changes in vivo and Treatment Response in Human NHL. Proceedings of the American Association in Cancer Research Annual Meeting, 1996.

47. Brown, T.R. and Stoyanova, R.; Novel Application of PCA in NMR: Automated Determination of Phase and Frequency Variation from Large Multispectral. Proceedings of the Experimental NMR Conference, 1996.

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48. Murphy-Boesch, J., Li, C.W., He, L. Padavic-Shaller, K., Negendank, W. and Brown, T.R.; Proton-Decoupled 19F CSI of 5-FU Catabolites in Human Liver. Proceedings of the Experimental NMR Conference, 1996.

49. Murphy-Boesch, J., He, L., Elsasser, C. and Brown, T.R.; Standardized Dual-Tune Surface Coils for Quantitative Comparison of 31P Data from Multi-Institutional Tumor Studies. Proceedings of The Experimental NMR Conference, 1996.

50. Gonen, O., LI, C.W., Murphy-Boesch, J., Negendank, W. and Brown, T.R., Simultaneous 19F and 31P 3-D Chemical Shift of Human Liver During Chemotherapy. Proceedings of the Experimental NMR Conference, 1996.

51. Gonen, O., Mohebbi, A., Stoyanova, R. and Brown, T.R.; 31P Signal Enhancement by Polarization Transfer from 1H in 3D CSI of Human Brain. Proceedings of the Society of Magnetic Resonance Annual Meeting, 1996.

52. Stoyanova, R., Li, C.W., Padavic-Shaller, K., Negendank, W. and Brown, T.R.; Automated Extraction of Tumor Spectra from Contaminated Voxels in 3-D 31P CSI Datasets. Proceedings of The Society of Magnetic Resonance Annual Meeting, 1996.

53. Arias-Mendoza, F., Elkashef, A., Stoyanova, R., Gold, J., Wyatt, J.R. and Brown, T.R.; CoQ10 Effect on Cognitive Functions and Bioenergetics in Schizophrenia: An Anatomically Localized 31P MRS Study. Proceedings of The Society of Magnetic Resonance Annual Meeting, 1996.

54. Murphy-Boesch, J., Li, C.W., He, L., Padavic-Shaller, K., Negendank, W. and Brown, T.R.; Proton-Decoupling Techniques for 19F CSI Imaging of 5FU Catabolites in Human Liver. Proceedings of the Society of Magnetic Resonance Annual Meeting, 1996.

55. Murphy-Boesch, J., He, L., Elsasser, C. and Brown, T.R.; Standardized Dual-Tune Surface Coils for Quantitative Comparison of 31P Data from Multi-Institutional Tumor Studies. Proceedings of the Society of Magnetic Resonance Annual Meeting, 1996.

56. Negendank, W., Padavic-Shaller, K., Li, C.W., Murphy-Boesch, J., Smith, M.R., Schilder, R.S., Millenson, M. and Brown, T.R.; Changes in Phosphoethanolamine and Treatment Response in Lymphomas. Proceedings of the Society of Magnetic Resonance Annual Meeting, 1996.

57. Li, C.W., Kuesel, C., Padavic-Shaller, K., Murphy-Boesch, J., Patchefsky, A., Eisenberg, B., Schmidt, R., Von Roemeling, R., Shaller, C., Negendank, W. and Brown, T.R.; Characterization of Soft Tissue Sarcomas by in vivo 1H-Decoupled 31P MRS of Tissue Extracts. Proceedings of the Society of Magnetic Resonance Annual Meeting, 1996.

58. Gonen, O., Arias-Mendoza, F., Javaid, T. and Brown, T.R.; Dual Nuclear MRS: 1H 2-D-CSI Interleaved with 1H-Decoupled 31P 3-D-CSI of Human Brain. Proceedings of the Society of Magnetic Resonance Annual Meeting, 1996.

59. Stoyanova, R. and Brown, T.R.; Correcting Frequency and Phase Errors using PCA. Proceedings of The Society of Magnetic Resonance Annual Meeting, 1996.

60. Gonen, O., Li, C.W., Murphy-Boesch, J., He, L., Negendank, W.G. and Brown, T.R.; Simultaneous 3D CSI of 1H-Decoupled 19F and 31P for 5FU Chemotherapy. Proceedings of the Society of Magnetic Resonance Annual Meeting, 1996.

61. Murphy-Boesch, J., Li, C.W., He, L., Padavic-Shaller, K., Negendank, W.G. and Brown, T.R.; Proton-Decoupled 19F CSI of 5-FU Catabolites in Human Liver. Proceedings of the Radiological Society of North America Annual Meeting, 1996.

62. Brown, T.R., Stoyanova, R., Li, C.W. and Padavic-Shaller, K.; Application of PCA for Identification and Quantitation of Spectral Patterns in CSI. Proceedings of the Radiological Society of North America Annual Meeting, 1996.

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63. Gonen, O., Arias-Mendoza, F. and Brown, T.R.; Dual Nuclear MRS: 1H 2D-CSI Interleaved with 1H-Decoupled 31P 3D-CSI of Human Brain. Proceedings of the Radiological Society of North America Annual Meeting, 1996.

64. Gonen, O., Li, C.W., Murphy-Boesch, J., Padavic-Shaller, K., Negendank, W.G. and Brown, T.R.; Simultaneous 3D CSI of 1H-Decoupled 19F and 31P in 5FU Chemotherapy. Proceedings of the Radiological Society of North America Annual Meeting, 1996.

65. Gonen, O., Mohebbi, A., Stoyanova, R. and Brown, T.R.; 31P Signal Enhancement by Polarization Transfer from 1H in 3D CSI of Human Brain. Proceedings of the Radiological Society of North America Annual Meeting, 1996.

66. Kappler, F., Djafroudi, S., Kayser, H., Su, B., Lal, S., Randall, W.C., Walker, M.A., Taylor, A., Szwergold, B.S., Erbersdobler, H. and Brown, T.R.; Metabolism of Fructoselysine in the Kidney. O’Brain, J., Nursen, H.E., Crabbe, M.J.C., Ames, J.M., Eds Cambridge, U.K.; the Royal Society of Chemistry, P 415. In Proceeding of the Sixth International Maillard Symposium, London 1997.

67. Gonen, O., Li, C.W., Murphy-Boesch, J., Padavic-Shaller, K., Negendank, W.G. and Brown, T.R., Choice of Optimal Simultaneous 1H-Decoupled 19F and 31P 3D CSI Method for 5FU Chemotherapy. Proceedings of the International Society of Magnetic Resonance in Medicine Annual Meeting, 1997.

68. Stoyanova, R., Gonen, O. and Brown, T.R.; Linewidths Estimation in Large Spectroscopy Datasets Using PCA. Proceedings ofThe International Society of Magnetic Resonance in Medicine Annual Meeting, 1997.

69. Brown, T.R., Stoyanova, R. and Arias-Mendoza, F.; Analysis of 31P 3-D CSI Spectra from the Human Calf Using PCA. Proceedings of the International Society of Magnetic Resonance in Medicine Annual Meeting, 1997.

70. Brown, T.R., Chapman, J.D., Murphy-Boesch, J., Movsas, B., Fein, D. and Padavic-Shaller, K.; Observation of Head and Neck Cancers with 1H-Decoupled 31P 3-D CSI. Proceedings of the International Society of Magnetic Resonance in Medicine Annual Meeting, 1997.

71. Arias-Mendoza, F., Grover, W.D., Salganicoff, L., Selak, M.A. and Brown, T.R.; Possible Creatine Synthesis Deficit Demonstrated by in vivo 31P NMR Spectroscopy. Proceedings of the International Society of Magnetic Resonance in Medicine Annual Meeting, 1997.

72. Arias-Mendoza, F., Elkashef, A., Stoyanova, R., Gold, J., Wyatt, J.R. and Brown, T.R., CoQ10 Effect on Cognitive Functions and Bioenergetics in Schizophrenia: An Anatomically Localized 31P MRS Study. Proceedings of the Magnetom Vision User Conference, 1997.

73. Stoyanova, R. and Brown, T.R.; Making Multidimensional Spectroscopy Practical: Application of PCA to CSI Data. Proceedings of the Magnetom Vision User Conference, 1997.

74. Brown, T.R., Chapman, D.J., Movsas, B. and Padavic-Shaller, K.; Observation of Head and Neck Cancers with 1H-Decoupled 31P CSI. Proceedings of the Radiological Society of North America Annual Meeting, 1997.

75. Arias-Mendoza, F., Grover, W.D., Salganicoff, L., Selak,, M.A. and Brown, T.R.; Possible Creatine Synthesis Deficit Demonstrated by in vivo 31P NMR Spectroscopy. Proceedings of the Radiological Society of North America Annual Meeting, 1997.

76. Gonen, O., Li, C.W., Murphy-Boesch, J., Negendank, W.G. and Brown, T.R.; Simultaneous 3-D CSI of 1H-Decoupled 19F and 31P in 5FU Chemotherapy. Proceedings of the Magnetom Vision User Conference, 1997.

77. Brown, T.R., Stoyanova, R., Paganini, A.T. and Meyer, A.R.; Application of PCA to Kinetic Muscle Data: Detecting The Finest Detail Possible. Proceedings of the European Society of Magnetic Resonance in Medicine and Biology Annual Meeting, 1997.

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78. Stoyanova, R., Arias-Mendoza, F. and Brown, T.R.; Application of PCA to CSI: A Way to Explore Complex Large. Proceedings of the European Society of Magnetic Resonance in Medicine and Biology Annual Meeting, 1997.

79. Arias-Mendoza, F., Konchanin, L.M., Grover, W.D., Salganicoff, L., Selak, M.A. and Brown, T.R.; Possible Creatine Synthesis Deficit Studied by in vivo NMR Spectroscopy. Proceedings of the American College of Sports Medicine Annual Meeting, 1998.

80. Arias-Mendoza, F., Konchanin, L.M., Grover, W.D., Salganicoff, L., Selak, M.A. and Brown, T.R.; Possible Creatine Synthesis Deficit Demonstrated by in vivo MRS. Proceedings of the Mitochondrial Medicine Conference, 1998.

81. Stoyanova, R., Houtman, C.J., Stegeman, D.F., Heerschap, A. and Brown, T.R.; Application of PCA for Quantitation of Kinetic Muscle Data: Comparison with VARPRO. Proceedings of the International Society of Magnetic Resonance in Medicine Annual Meeting, 1998.

82. Stoyanova, R., Paganini, A.T., Meyer, R.A. and Brown, T.R.; Application of PCA of Kinetic Muscle Data: An Integrated Analysis Approach. Proceedings of the International Society of Magnetic Resonance in Medicine Annual Meeting, 1998.

83. Arias-Mendoza, F., Konchanin, L.M., Grover, W.D. and Brown, T.R.; Familial Creatine Deficiency with a Myopathic Component" Near-Absent Signals in the 1H-Decoupled 31P NMR of Calf. Proceedings of the International Society of Magnetic Resonance in Medicine Annual Meeting, 1998.

84. Arias-Mendoza, F., Stoyanova, R. and Brown, T.R.; PCA of Human Tumor Spectra. Proceedings of the International Society of Magnetic Resonance in Medicine Annual Meeting, 1998.

85. Ochs, M.F., Stoyanova, R. and Brown, T.R.; Spectral Decomposition by Bayesian Methods. Proceedings of The International Society of Magnetic Resonance in Medicine Annual Meeting, 1998.

86. Stoyanova, R., Houtman, C.J., Arias-Mendoza, F. and Brown, T.R.; Application of PCA for Spectral Quantitation: Comparison with Established Quantitation Techniques. Proceedings of the Experimental NMR Conference, 1998.

87. Arias-Mendoza, F., Stoyanova, R. and Brown, T.R.; PCA of 31P NMR Spectroscopy of NHL. Proceedings of The Experimental NMR Conference, 1998.

88. Arias-Mendoza, F., Brown, T.R., Charles, H.C., Zakian, K., Leach, M.O., Griffiths, J.R., Nelson, S.J., Heerschap, A., Glickson, J.D. and Evelhoch, J.L.; Methodological Standardization for a Multi-Institutional in vivo Trial of Localized 31P MR Spectroscopy in Human Cancer Research. Proceedings of The Workshop in MR in Experimental and Clinical Cancer Research, 1998.

89. Arias-Mendoza, F., Brown, T.R., Charles, H.C., Zakian, K., Leach, M.O., Griffiths, J.R., Nelson, S.J., Heerschap, A., Glickson, J.D. and Evelhoch, J.L.; Methodological Standardization for a Multi-Institutional in vivo Trial of Localized 31P Spectroscopy in Human Cancer Research. Proceedings of the Experimental NMR Conference, 1999.

90. Ochs, M.F., Stoyanova, R.S., Brown, T.R., Rooney, W.D., Li, X., Lee, J-H. And Springer, C.S. Jr.; PCA and Bayesian Spectral Decomposition Methods for Accomplishing Relaxographic Imaging. Proceedings of The Experimental NMR Conference, 1999.

91. Arias-Mendoza, F., Stoyanova, R. and Brown, T.R.; PCA of 31P NMR Spectroscopy of NHL. Proceedings of The American Association in Cancer Research Annual Meeting, 1999.

92. Arias-Mendoza, F., Brown, T.R., Charles, H.C., Zakian, K., Schwarz, A., Doyle, V.L., Nelson, S.J., Rijpkema, M., Glickson, J.D. and Evelhoch, J.L.; Methodological Standardization for a Multi-Institutional in vivo Trial of Localized 31P Spectroscopy in Human Cancer. Proceedings of the International Society of Magnetic Resonance in Medicine Annual Meeting, 1999.

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93. Arias-Mendoza, F., Berardocco, F., Li, C.W., Negendank, W.G. and Brown, T.R.; Differential 31P Spectral Pattern of Human Spleen in Health and Disease Using 3-D-Localized 1H-Decoupled 31P NMR. Proceedings of The International Society of Magnetic Resonance in Medicine Annual Meeting, 1999.

94. Arias-Mendoza, F., Selak, M.A., Konchanin, L., Salganicoff, L. and Brown, T.R.; Possible Creatine Synthesis Deficit Demonstrated by in vivo 31P NMR Spectroscopy, Proceedings of the Child Neurology Society Annual Meeting 1999.

95. Arias-Mendoza, F., Selak, M.A., Melvin, J., Assadi, M., Salganicoff, L., Grover, W.D., Kaye, E. and Brown, T.R.; A Simple in vivo 31P Spectroscopy Protocol to Study Active Muscle Non-Invasively in Pediatric Patient with Neuromuscular Diseases. Proceedings of the Child Neurology Society Annual Meeting, 1999.

96. Arias-Mendoza, F., Berardocco, F., Li, C.W., Negendank, W.G. and Brown, T.R.; Differential 31P Spectral Pattern of Human Spleen in Health and Disease Using 3-D-Localized 1H-Decoupled 31P NMR. Proceedings of The Radiological Society of North America Annual Meeting, 1999.

97. Arias-Mendoza, F., Brown, T.R., Charles, H.C., Koutcher, J.A., Leech, M., Griffiths, J.R., Nelson, S.J., Heershap, A., Glickson, J.D. and Evelhoch, J.L.; Preliminary Result on a Multi-Institutional in vivo Trial of Localized 31P MR Spectroscopy in Human Cancer Research, Proceedings of the Society Radiological North of America Annual Meeting, 1999.

98. Arias-Mendoza, F., Selak, M.A., Melvin, J., Assadi, M., Salganicoff, L., Grover, W.D., Kaye, E. and Brown, T.R.; A Simple in vivo 31P Spectroscopy Protocol to Study Active Muscle Non-Invasively in Pediatric Patient with Neuromuscular Diseases. Proceedings of the Radiological Society of North America Annual Meeting, 1999.

99. Brown, T.R., Ochs, M.F. and Stoyanova, R.; Automatic Segmentation of Relaxographic Data in MRI. Proceedings of the Bioimaging Symposium, 1999.

100. Arias-Mendoza, F., Smith, M.R., Berardocco, F. and Brown, T.R.; in vivo Phosphorus MRS Aids in Clinical Aggressiveness Determination and Early Prediction of Treatment Response NHL . Proceedings of The Bioimaging Symposium, 1999.

101. Arias-Mendoza, F., Brown, T.R., Griffiths, J.R., Leech, M., Zakian, K., Charles, H.C., Nelson, S.J., Heershap, A., Glickson, J.D. and Evelhoch, J.L.; Preliminary Result on a Multi-Institutional in vivo Trial of Localized 31P MR Spectroscopy in Human Cancer Research. Proceedings of the European Society of Magnetic Resonance in Medicine and Biology Annual Meeting, 1999.

102. Arias-Mendoza, F., Smith, M.R., Berardocco, F., Li, C.-W., Negendank, W.G. and Brown, T.R.; Correlation of Analysis of 31P MR Spectroscopy in vivo with Malignancy and Treatment Response in NHL. Proceedings of The European Society of Magnetic Resonance in Medicine and Biology Annual Meeting, 1999.

103. Arias-Mendoza, F., Berardocco, F., Li, C.W., Negendank, W.G. and Brown, T.R.; Differential 31P Spectral Pattern of Human Spleen in Health and Disease Using 3D-Localized 1H-Decoupled 31P NMR. Proceedings of The European Society of Magnetic Resonance in Medicine and Biology Annual Meeting, 1999.

104. Arias-Mendoza, F., Konchanin, L., Selak, M.A., Kaye, E. and Brown T.R.; Family Creatine Deficiency With A Myophatic Component: Near-absent Signals in The 1H-Decoupled 31P MR Spectra. Proceedings of the European Society of Magnetic Resonance in Medicine and Biology Annual Meeting, 1999.

105. Stoyanova, R. and Brown T.R.; General Application of PCA for Spectral Analysis. Proceedings of the International Society of Magnetic Resonance in Medicine Annual Meeting, 2000.

106. Arias-Mendoza, F., Brown, T.R., Schwarz, A., Zakian, K., Tate, R., Stubbs, M., Leech, M.O., Griffiths, J.R., Koucher, J.S., Charles, H.C., Nelson, S.J., Heershap, A., Glickson, J.D. and Evelhoch, J.L.; Preliminary Result of Multi-Institutional Trial to Demonstrate Clinical Predictive Value of in vivo Localized 31P MRS in NHL. Proceedings of The International Society of Magnetic Resonance in Medicine Annual Meeting, 2000.

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107. Arias-Mendoza, F., Smith, M.R. and Brown, T.R.; Pre-Treatment Phosphorus MRS Aids in Determination of Tumor Aggressiveness and Early Prediction of Treatment NHL. Proceedings of the International Society of Magnetic Resonance in Medicine Annual Meeting, 2000.

108. Serrai, H., Zakian, K., Arias-Mendoza, F., Nelson, J.S., Koutcher, J.A., Rosenthal, D.I., Brown, T.R., Charles, H.C., Leach, M.O., Grifffiths, J.R., Evelhoch, J.L., Heerschap, A. and Glickson J.D.; Monitoring Response of Head and Neck Tumors to Therapy Using in vivo Localized 31P Decoupled MRS. Proceedings of The International Society of Magnetic Resonance in Medicine Annual Meeting, 2000.

109. Ochs, M.F., Stoyanova, R., Brown, T.R., Rooney, W.D. and Springer, C.S. Jr.; Differences in T1

Distributions Between Normal Volunteer and MS Patients Identified by Bayesian Decomposition Relaxographic Imaging. Proceedings of The International Society of Magnetic Resonance in Medicine Annual Meeting, 2000.

110. Ochs, M.F., Stoyanova, R., Brown, T.R., Rooney, W.D., Li, X., Lee, J-H. And Springer, C.S. Jr.; Differences in T1 Distributions Between Normal Volunteer and MS Patients Identified by Bayesian Decomposition Relaxographic Imaging. Proceedings of the Experimental NMR Conference, 2000.

111. Arias-Mendoza, F., Smith, M.R. and Brown, T.R.; Predicting Treatment Response in NHL for Pre-Treatment Levels of PE and PC Measured by in vivo 31P MRS. Proceedings of the Experimental NMR Conference, 2000.

112. Stoyanova, R., Brown, T.R., Lindon, J.C., Nicholls, A.W. and Nicholson, J.K.; A New Method of NMR Spectral Alignment for Improved Pattern Recognition Analysis. Proceedings of the Experimental NMR Conference, 2000.

113. Arias-Mendoza, F., Brown, T.R. and Smith, M.R.; Preliminary Result on a Multi-Institutional Trial of in vivo Localized 31P MRS in Human Cancer Research. Proceedings of the American Association in Cancer Research Annual Meeting, 2000.

114. Arias-Mendoza, F., Smith, M.R. and Brown, T.R.; In vivo Phosphorus MRS Aids in Clinical aggressiveness determination and Early Prediction of treatment Response NHL. Proceedings of the American Association in Cancer Research Annual Meeting, 2000.

115. Arias-Mendoza, F., Smith, M.R. and Brown, T.R.; Treatment Response in NHL is Predicted by Pre-Treatment Level of Phosphoethanolamine and Phosphocholine Measured by in vivo Phosphorus MR Spectroscopy. Proceedings of the Workshop in MR in Experimental and Clinical Cancer Research, 2000.

116. Arias-Mendoza, F., Schwarz, A., Zakian, K., Tate, R., Stubbs, M., Brown, T.R., Leech, M.O., Griffiths, J.R., Koucher, J.S., Charles, H.C., Nelson, S.J., Heershap, A., Glickson, J.D. and Evelhoch, J.L.; Investigation of The Predictive value of Phosphoethanolamine and Phosphocholine measured in vivo 31P MR Spectroscopy in NHL in a Multi-Institutional Setting. Proceedings of the Workshop in MR Applications in Experimental and Clinical Cancer Research, 2000.

117. Stoyanova, R., Swanson, M.G., Ochs, M., Arias-Mendoza, F., Vigneron, D.B., Kurhanewickz, J. and Brown, T.R.; Identification of Spectral Signatures to the Tissue Composition of the Sample. Proceedings of The Workshop in MR Applications in Clinical and Experimental Cancer Research, 2000.

118. Arias-Mendoza, F., Smith, M.R. and Brown, T.R.; Treatment Response in NHL is Predicted by Pre-Treatment Level of PEtha and PChol Measured by in vivo Phosphorus MR Spectroscopy. Proceedings of The European Society of Magnetic Resonance in Medicine and Biology Annual Meeting, 2000.

119. Arias-Mendoza, F., Schwarz, A., Zakian, K., Tate, R., Stubbs, M., Brown, T.R., Leech, M.O., Griffiths, J.R., Koucher, J.S., Charles, H.C., Nelson, S.J., Heershap, A., Glickson, J.D. and Evelhoch, J.L.; Investigation of The Predictive Value of PEtha and PChol Measured in vivo 31P MR Spectroscopy In NHL In A Multi-Institutional Setting. Proceedings of the European Society of Magnetic Resonance in Medicine and Biology Annual Meeting, 2000.

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120. Poptani, H., Loevner, L., Shukla-Dave, A., Serrai, H., Zakian, K., Arias-Mendoza, F., Nelson, J.S., Koutcher, J.A., Rosenthal, D.I., Brown, T.R., Charles, H.C., Leach, M.O., Grifffiths, J.R., Evelhoch, J.L., Heerschap, A. and Glickson J.D.; Serial in vivo Localized 31P Decoupled MR Spectroscopy of Head and Neck Tumors: A Preliminary Study. Proceedings of the European Society of Magnetic Resonance in Medicine and Biology Annual Meeting, 2000.

121. Ochs, M., Stoyanova, R., Brown, T.R., Rooney, W.D., Li, X. and Lee, J-H.; Differences in T1 Distribution between Normal Volunteers and MS Patients Identified by Bayesian Decomposition Relaxographic Imaging. Proceedings of The Radiological Society of North America, 2000.

122. Arias-Mendoza, F., Cruz-Lobo, J., Berardocco, F. and Brown, T.R.; Investigation of The Tumor Content of Phospholipid-Related Compounds Measured by in vivo 31P MR Spectroscopy in Advanced Breast Carcinoma, Annual Meeting of The International Society Of Magnetic Resonace In Medicine, Honolulu, HI, USA, 2002.

123. Arias-Mendoza,F., Cruz-Lobo, J. and Brown, T.R.; Is bone marrow MRI More Specific Than Bone Scintigraphy to Predict Metastasis? Annual Meeting of the International Society of Magnetic Resonance in Medicine, Honolulu, HI, USA, 2002.

124. Coon, A.L., Arias-Mendoza, F., Cruz-Lobo, J., Berardocco, F., Mocco, J., Colby, G.P., King, R., Mack, J., Brown, T.R. and Connolly E.S.; Characterization of Experimental Primate Stroke Using 1H Magnetic Resonance Spectroscopy. Annual Meeting of the Society of Neurological Surgeons, Philadelphia, PA, USA, 2002.

125. Coon, A.L., Arias-Mendoza, F., Mack, J., King, R., Colby, G.P., Cruz-Lobo, J., Ziv, E., Brown, T.R. and Connolly, E.S.; In vivo Characterization of Experimental Primate Stroke Using 31P Magnetic Resonance Spectroscopy. Annual Meeting of the American Association of Neurosurgery, USA, 2002.

126. Arias-Mendoza, F., Stoyanova, R., Cruz-Lobo, J., Ziv, E. and Brown, T.R.; Principal Component Analysis Of 31P MR Spectroscopy of Human Non-Hodgkin's Lymphomas in situ. Workshop On in vivo Functional and Molecular Assessment of Cancer, Santa Cruz, CA, USA, 2002.

127. Coon, A.L., Arias-Mendoza, F., Mack, J., Colby, G.P., King, R., Cruz-Lobo, J., Brown, T.R. and Connolly, E.S.; Magnetic Resonance Spectroscopic Footprint of Hyper-Acute Global Brain Anoxia in Primates. Annual Meeting of the Stroke Society, 2003.

128. Tang, H., Tabert, M.H., Alberts, M., Devanand, D.P., Wu, E.X. and Brown, T.R.; An Optimized EPI Pulse Sequence Using SENSE For fMRI Studies of Orbitofrontal and Medial Temporal Brain Areas. 12 th Scientific Meeting of ISMRM, May 15-21, Kyoto, Japan, 2004.

129. Zhao, Q., Patriotis, P., Arias-Mendoza, F., Stoyanova, R. and Brown, T.R.; An Interactive Software for 3D Chemical Shift Imaging Data Analysis and Real Time Spectral Localization and Quantification. ENC 2004.

130. Zhao, Q., Patriotis, P., Arias-Mendoza, F., Stoyanova, R. and Brown, T.R.; An Interactive Software for 3D Chemical Shift Imaging Data Análisis and Real Time Spectral Localization and Quantification. ISMRM 2005.

131. Robinson, J.N., Clearly-Goldman, J., Fineberg, B., Mulkern, R., Tempany, C., Arias-Mendoza, F., Cruz-Lobo, J. and Brown, T.R.; Antenatal Detection of Fetal Lactate With Non-Invasive Testing Using 2D-Localized Proton Magnetic Resonance Spectroscopy. 24th Annual Scientific Meeting of The Society For Maternal-Fetal Medicine (Submitted).

132. Brittenham, G.M., Tosti, C., Golay, X., Van Cauteren, M., Lekprasert, V., Tangpukdee, N., Krudsood, S., Leowattana, W., Wilairatana, P., Swaminathan, S.V., DeLaPaz, R.L., Brown, T.R., Looareesuwan, S. and Laothamatas, J.; Hemolytic Anemia and Thromobocytopenia Associated with Ischemic Brain Lesions in Patients with Acute Uncomplicated Plasmodium Falciparum Malaria. 48th ASH Annual Meeting 2006.

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133. Tosti, C.L., Tang, H., Jensen, J.N., Sheth, S., Swaminathan, S.V., Hultman, K., Azabagic, A., Altmann, K., Prakash, A., Printz, B.F., Brown, A.L., Hordof, A.J., Olivieri, N.F., Brittenham, G.M. and Brown, T.R.; MR Estimation of Muocardial Ferritin Iron in Thalassemia Major. ISMRM 2006.

134. Brown, T.R., Shapley, N.C. and Tang, H.; Pseudo Random Amplitude Modulation: A High Efficiency Method to Measure Flow and Perfusion. ISMRM 2006.

135. Zhao, Q., Patriotis, P., Swaminathan, S.V., Arias-Mendoza, F., Stoyanova, R., Laothamatas, J., Looareesuwan, S., Brittenham, G.M. and Brown, T.R.; Advanced Spectral Analysis and Quantification Using 3D Interactive Chemical Shift Imaging (3DiCSI). ISMRM 2006.

136. Zhao, Q., Stoyanova, R., Du, S., Sajda, P. and Brown, T.R.; Software Tool for Comprehensive Assessment and Interpretation of Metabolomic Data. ISMRM 2006.

137. Asllani, I., Habeck, C., Borogovac, A., Stern, Y. and Brown, T.R.; Combining CASL with Uni- and Multi-Variate Methods for Early Detection of Alzheimer’s Disease. ISMRM 2006

138. Stoyanova, R., Du, S., Wang, Y., Zhao, Q., Holmes, E., Utzinger, J., Sajda, P. and Brown, T.R.; Across Species Metabonomics: Identification of Common Spectral Changes in Mouse and Hamster Urine, Caused by Parasite Infection. ISMRM 2006.

139. Zhao, Q., Stoyanova, R., Du, S., Sajda, P. and Brown, T.R.; High Resolution Spectroscopy: A Software Program for Comprehensive Assessment and Interpretation of Metabolomic Data. ENC Meeting 2006.

140. Zhao, Q., Patriotis, P., Arias-Mendoza, F., Stoyanova, R. and Brown, T.R.; 3D Interactive Chemical Shift Imaging: A comprehensive Software Program for Data Analysis and Quantification. ENC Meeting 2006.

141. Goldman, R., Gerson, A., Cohen, M., Brown, T.R. and Sajda, P.; Simultaneous EEG and fMRI for Event Related Studies. 11th Annual OHBM Meeting 2006.

142. Tabert, M., Steffener, J., Reisman, S., Brown, T.R. and Devanand, D.; Comparing Statistical Models of Olfactory fMRI Data. 11th Annual OHBM Meeting 2006.

143. Sheth, S., Brown, T.R., Tosti, C.L., Brown, A., Swaminathan, S., Prakash, A., Tang, H., Hordof, A., Altmann, K.Printz, B. and Azabagic, A.; Increasing Myocardial Ferritin Iron Concentrations Predict Declining Left Ventricular Function in Thalassemia. Pediatric Academic Societies Annual Meeting, 2006.

144. Laothamatas, J., Tosti, C.L., Golay, X., Cauteren, M.V., Leprasert, V., Tangpukdee, N., Krudsood, S., Leowattana, W., Wilairatana, P., Swaminathan, S.V., DeLaPaz, R.L., Brown, T.R. and Brittenham, G.M.; Magnetic Resonance Imaging (MRI) Evidence of White Matter Injury in Patients With Acute Uncomplicated Falciparum Malaria. Presentation at the 55th Annual Meeting 2006.

145. Goldman, R.I., Gerson, A.D., Philiastides, M.G., Friedman, D., Brown, T.R. and Sajda, P.; Quality of Single-Trial Discrimination in Simulataneous EEG/fMRI. ISMRM Meeting 2007.

146. Stoyanova, R., Zhao, Q., Ralston, S., Hodavance, M.S., Pelczer, I. and Brown, T.R.; Decomposition of 1H NMR Spectra of Blood Plasma for Identification of Complex Metabolic Response to Glusoce Uptake. ISMRM Meeting 2007.

147. Zhao, Q., Stoyanova, R., Clarke, N., Pelczer, I. and Brown, T.R.; Improved Procedure for Automatic Alignment of Strongly Overlapping Peak-Region in High-Resolution 1H NMR Spectra. ISMRM Meeting 2007.

148. Swaminathan, S.V., Tosti, C.L., Hultman, K., Jenson, J.H., Nunez, A., Wu, E.X., Sheth, S., Brittenham, G.M. and Brown, T.R.; Validation of Clinically Useful Fast, Multi Slice, Multi Echo T2 Quantification Sequence. ISMRM Meeting 2007.

149. Swaminatha, S.V., Murdoch, J., Tosti, C.L., Brown, T.R. and Newstead, G.; Evaluation of Dual Band Basing Pulse in Breast Spectroscopy. ISMRM Meeting 2007.

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150. Asllani, I., Borogovac, A., Wright, C., Ichise, M., Brown, T.R., Zarahn, E. and Krakauer, J.W.; Detecting CBF Changes Distant From Cerebral Infarct (Diaschisis) Using CASL MRI. ISMRM Meeting 2007.

151. Asllani, I., Habeck, C., Borogovac, A., Tatarina. O., Brown, T.R., Basner, R.C. and Stern, Y.; Effects of 48hr Sleep Deprivation on Cerebral Blood Flow Measured with Arterial Spin Labeling MRI. ISMRM Meeting 2007.

152. Habeck, C., Asllani, I., Borogovac, A., Scarmeas, N., Brown, T.R. and Stern, Y.; Identification of a Multivariate Biomarker of Alzheimer’s Disease with ASL. ISMRM Meeting 2007.

153. Jensen, J.H., Swaminathan, S.V., Tosti, C.L., Szulc, K.U., Hultman, K., Wu, E.X., Nunez, A., Sheth, S., Brittenham, G.M. and Brown, T.R.; Quantification of Ferritin Iron in Presence of Hemosiderin. ISMRM Meeting 2007.

154. Cheung, J.S., Chow, A.M., Jensen, J.H., Brown, T.R., Brittenham, G.M. and Wu, E.X.; MRI Characterization of Iron in Soluble and Particulate Mixtures MRI Characterization of Iron in Soluble and Intracellular Particulate Mixtures. ISMRM Meeting 2007.

155. Tosti, C.L., Petersen, E.T., Laothamatas, J., Golay,X., Swaminathan, S.V., Cauteren, M.V.,Murdoch, J., Lekprasert,V., Tangpukdee, N., Krusood, S.,Leowattana,W., Wilairatana, P., DeLaPaz, R.L., Brown, T.R. and Brittenham, G.M.; Cerebrospinal Fluid Lactate in P. Falciparum Malaria: Measurement by Chemical Shift Imaging at 3Tesla. ISMRM Meeting 2007.

156. Yang, Y., Zhao, Q., Swaminathan, S.V., Fischer, S. and Brown, T.R.; Fast Chemical Shift Imaging with Ultra Short Echo Time. ISMRM Meeting 2007.

157. Yang, Y., Zhao, Q., Swaminathan, S.V., Wright, C.B., Sacco, R.L. and Brown, T.R.; Water Lineshape Analysis Identifies Region of WMH. ISMRM Meeting 2007.

158. Hultman, K.; Immunotargeting of MHC Class II-Expressing Cells Using y-Fe203 Nanoparticle MR Contrast Agents. ISMRM Meeting 2007.

159. Lee, W-N, Qian, Z., Tosti, C.L., Swaminathan, S.V., Brown, T.R., Metaxas, D.N. and Konofagou, E.E.; Validation of 2D Ultrasound-Based Strain Estimates with MR Tagging. ISMRM Meeting 2007.

160. Ooi, M.B., Yang, Y., Swaminathan, S.V. and Brown, T.R.; Fast Absolute Quantitation Using FID Echo Planar Chemical Shift Imaging (FID EP-CSI). ISMRM Meeting 2007.

161. Ooi, M.B., Yang, Y., Swaminathan, S.V. and Brown, T.R.; Fast Absolute Quantitation of Brain Metabolites at 3 Tesla Using FID EP-CSI. ISMRM Meeting 2007.

162. Choi, J.J., Small, S.A., Brown, T.R. and Konofagou, E.; Non-Invasive Generation and Monitoring of Ultrasound-Induced Blood-Brain Barrier Opening in the Murine Hippocampus. ISMRM Meeting 2007.

163. Brown, T.R.; Extending fMRI with Arterial Spin Labeling and EEG. Medical Imaging Course 2007.

164. Brown, T.R., Habeck, C., Borogovac, A., Scarmeas, N., Stern, Y. and Asllani, I.; Spatial Patterns in CBF Depression in Alzheimer’s Disease From Multivariate Analysis of Continuous Arterial Spin Labeling MRI. Alzheimer’s Association 2007 (Submitted), International Conference 2007.

165. Wu, E.X.; Cheung, J.S., Chow, A.M., Jensen, J.H., Brown, T.R., Au, W.Y., Ha, S.Y., Sheth, S., Brittenham, G.M.; MRI Characterization of Ferritin-Like and Hemosiderin-Like Iron. International BioIron Society 2007.

166. Goldman, R.I., Gerson, A., Philiastides, M., Friedman, D., Brown, T.R., Sajda, P.; The Effect of Simultaneous EEG/fMRI on the Fidelity of Single-Trial EEG Components. ISMRM Meeting 2007.

167. Arias-Mendoza, F. and Brown, T.R.; Predicting Treatment Response for Non-Hodgkin’s Lymphoma: A Multi-Institutional MR Spectroscopy Study. AACR 2007.

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168. Borogovac, A., Krakauer, J.W., Brown, T.R. and Asllani, I.; Dependence of Functional ASL MRI Signal on Number of Slice Acquisitions. ISMRM 2008.

169. Asllani, I., Borogovac, A., Brown, T.R. and Marshall, R.S.; Characterizing the Effect of Carotid Occlusion on CBF Using ASL Perfusion MRI. ISMRM 2008.

170. Asllani, I., Borogovac, A., Brown, T.R., Kumar, A. and Stern, Y.; Detecting Age-Related Changes in Resting CBF Using CASL MRI. ISMRM 2008.

171. Stoyanova, R., Pelczer, I., Hachem, P., Zhao, Q., Brown, T.R. and Pollack, A.; Metabolic Biomarkers in Blood Plasma of Tumor Bearing Mice Detected by 1H NMR Spectra. ISMRM 2008.

Patents, Patent Applications:

1. Brown, T.R.; Nuclear Magnetic Resonance Imaging In Space and Frequency Coordinates. U.S. Patent 4,319,190, March 9, 1982.

2. Brown, T.R.; Magnetic Micro-Particles as Contrast Agents in Nuclear Magnetic Resonance Imaging. Canadian Patent (485,587), April 24, 1990.

3. Szwergold, B.S., Brown, T.R., Kappler, F. and Petersen, A.; A Method For Assessing Risk of Diabetes-Associated Pathologic Conditions and Efficacy of Therapies For Such Conditions. U.S. Patent 5,231,031, July 27, 1993.

4. Brown, T.R., Kappler, F., Szwergold, B., Lal, S. and Su, B.; Compounds and Methods For Therapeutic Intervention in Preventing Diabetic Complications and Procedures For Assessing A Diabetic’s Risk of Developing Complications and Determining The Efficacy of Therapeutic Intervention. US Patent number 6,004,958, 1999.

5. Ochs, M, Brown, T.R., Stoyanova, R. and Patriotis, C.; Methods of Decomposing Complex Data. US Patent Application, February 1999.

6. Brown, T.R., Kappler, F. and Seeholzer, S.; Method for Reducing A Susceptibility To Tumor Formation Induced By 3-Deoxyglucosone and Precursors Thereof. US Patent Application, April 1999.

7. Ochs, M.F., Brown, T.R., Stoyanova, R. and Patriotis, C.; Methods of Decomposing Complex Data. US Patent Application, July 2004.

8. Brown, T.R.; Compounds and Methods For Therapeutic Intervention in Preventing Diabetic Complications and Procedures for Assessing a Diabetic’s Risk of Developing Complications and Determining the Efficacy of Therapeutic Intervention. US Patent Application, July 4, 2006.

9. Hultman; K., Willis; A., O'Brien, S., Brown, T.R., Harris, P., Turro, N.J. and Grzenda, A.L.; Synthesis And Conjugation Of Iron Oxide Nanoparticles To Antibodies For Targeting Specific Cells Using Fluorescence And MR Imaging Techniques. US Patent Application, March 29, 2006.

10. Brown, T.R.; Complex Amplitude Modulation In Blood Flow And Perfusion Measurement. US Patent

Application, March 9, 2006.

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