Curriculum Vitae Name: Yusuke Nakamura Position: Professor, Department of Medicine, Section of Hematology/Oncology

Professor, Department of Surgery Deputy Director, Center for Personalized Therapeutics The University of Chicago 900E 57th Street KCBD6130

Chicago, IL 60637 Date of Birth: December 8th, 1952 Nationality: Japanese Business Address: The University of Chicago

Knapp Center for Biomedical Discovery 900 E. 57th Street, KCBD6130 Chicago, IL 60637

Tel: 773-834-1405

e-mail：ynakamura@medicine.bsd.uchicago.edu Education: Graduated from Osaka University Medical School in March 1977 1977 May Medical Doctor's License in Japan 1984 August Ph. D. of molecular genetics from Osaka University for a thesis entitled: "Sequences of cDNAs for human salivary and pancreatic alpha-amylases" Occupation: 1977 May - 1981 March Second Department of Surgery, Osaka University School of Medicine 1981 April - 1984 October Research fellow Institute for Molecular and Cellular Biology Osaka University 1984 October - 1988 December Research Associate Howard Hughes Medical Institute University of Utah 1987 September - 1989 August Research Assistant Professor Department of Human Genetics University of Utah 1989 January - 1989 August Senior Associate Howard Hughes Medical Institute

University of Utah 1989 April - 1995 March Head of Biochemistry Department Cancer Institute, Tokyo 1996 April - 1999 March Professor, Department of Clinical Genetics Osaka University School of Medicine 1995 April – 2000 March Head, Division of Genome Analysis Cancer Institute, Tokyo 1994 October – 2012 March Professor, Laboratory of Molecular Medicine Institute of Medical Science The University of Tokyo 1995 April – 2011 January Director, Human Genome Center Institute of Medical Science The University of Tokyo 2000 April-2005 March Group leader for Genotyping RIKEN SNP Research Center 2005 April-2010 March Director, RIKEN Center for Genomic Medicine 2011 January-December Special Advisor to the Cabinet Secretary General, Office of Medical Innovation, Cabinet Secretariat, Government of Japan 2012 April-present

Professor, Department of Medicine, Section of Hematology/Oncology Professor, Department of Surgery Deputy Director, Center for Personalized Therapeutics The University of Chicago

Member in the Editorial (or Advisory) Board for Annals of Human Genetics Cancer Science (Editor-in-Chief) Cancer Research (Senior Editor 2004-2007, Deputy Editor 2008-2009) Cell Cycle Clinical Genetics Genes Chromosomes & Cancer

Molecular Cancer Research International Journal of Oncology Journal of Human Genetics (Editor-in-Chief 1997-2007) Neoplasia Members in Japan Society of Human Genetics (President, 2007-2010) Japanese Cancer Association (board member 2002-2013, Preseident for the 2013 annual meeting) American Association of Cancer Research American Society of Human Genetics Science Council of Japan (2005-2012) Awards 1991 Honorary Citizenship, The State of Maryland, USA 1992 Princess Takamatsu Cancer Research Award 1993 The Research Award of Japanese Foundation for Cancer Research 1995 The Award of the Japanese Society of Human Genetics 1996 Takeda Medical Prize 2000 Keio Medical Science Prize 2002 The Tomizo Yoshida Award of the Japanese Cancer Association 2004 The Medal with a Purple Ribbon (for contributions to education and culture) 2006 Bulgarian Academy of Medical Science, Foreign Member 2010 Chen Award for Distinguished Academic Achievement in Human Genetic and Genomic Research

(HUGO) 2011 Member, Association of American Physicians (AAP) 2011 Honorary Professor, Harbin Medical University 2011 IPIT Award

2013 Honorary Professor, Taipei Medical University

Meeting organizers 2010 JCA-AACR Cancer Conference Co-chairman with Prof. Peter Jones (at Waikoloa, Hawaii in February 5-9, 2010) 2013 President, 72th JCA (Japan Cancer Association) meeting (at Yokohama in October 3-5, 2013)

Publication

Journal Total

Am. J. Human Genetics 33

Biochemical and Biophysical Research Communications 16

British Journal of Cancer 13

Cancer 6

Cancer Research 114

Cancer Science 49

Cell 2

Clinical Cancer Research 29

Cytogenetics Cell Genetics 59

Genes Chromosomes and Cancer 44

Genomics 84

Human Genetics 34

Human Molecular Genetics 58

Human Mutation 12

International Journal of Oncology 27

Journal of Clinical Oncology 2

Journal of Human Genetics 124

Lancet 6

Molecular Cell 1

Nature 17

Nature Cell Biology 2

Nature Communications 3

Nature Genetics 68

Neoplasia 12

New Eng. J. Med. 7

Oncogene 51

Oncotarget 1

Pharmacogenetics and Genomics 9

Proc. Natl. Acad. Sci. USA 8

Science 11

Others 424

Total 1326 (At 2014.01.19)

List of papers cited more than 300 times (at January 20, 2014) B. Vogelstein, E.R. Fearon, S.R. Hamilton, S. Kern, A.C. Presinger, M. Leppert, Y. Nakamura, R. White, L. Smets and J.L. Bos: Genetic alterations during colorectal tumor development. New Eng. J. Med., 319:525-532, 1988

5378

The International HapMap Consortium: A haplotype map of the human genome. Nature, 437:1299-1320, 2005

2911

The International HapMap Consortium: The International HapMap Project. Nature, 426:789-796, 2003

2877

The International HapMap Consortium: A second generation human haplotype map of over 3.1 million SNPs. Nature, 449:851-861, 2007

2475

K.W. Kinzler, M.C. Nilbert, L. Su, B. Vogelstein, T.M. Bryan, D.B. Levy, K.J. Smith, A.C. Preisinger, P. Hedge, D. McKechnie, R. Finniear, A. Markham, J. Groffen, M.S. Boguski, S.F. Alschul, A. Horii, H. Ando, Y. Miyoshi, Y. Miki, I. Nishisho, Y. Nakamura: Identification of FAP locus genes from chromosome 5q21. Science, 253:661-665, 1991

1954

Y. Nakamura, M. Leppert, P. O'Connell, Roger Wolff, T. Holm, M. Culver, C. Martin, E. Fujimoto, M. Hoff, E. Kumlin and R. White: Variable number of tandem repeat (VNTR) markers for human gene mapping. Science, 235:1616-1622, 1987

1700

S.J. Baker, E.R. Fearon, J.M. Nigro, S.R. Hamilton, A.C. Preisinger, J.M. Jessup, P. vanTuinen, D.H. Ledbetter, D.F. Barker, Y. Nakamura, R. White and B. Vogelstein: Chromosome 17 Deletions and p53 mutations in Colorectal Carcinomas. Science, 244:217-221, 1989

1672

I. Nishisho, Y. Nakamura, Y. Miyoshi, Y. Miki, H. Ando, A. Horii, K. Koyama, J. Utsunomiya, S. Baba, P. Hedge, A. Markham, A.J. Krush, G. Petersen, S.R. Hamilton, M.C. Nilbert, D.B. Levy, T.M. Bryan, A.C. Preisinger, K.J. Smith, L. Su, K.W. Kinzler, and B. Vogelstein: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science, 253:665-669, 1991

1449

B. Vogelstein, E.R. Fearon, S.E. Kern, S.R. Hamilton, A.C. Preisinger, Y. Nakamura and R. White: Allelotype of colorectal carcinomas. Science, 244:207-211, 1989

1272

K. Oda, H. Arakawa, T. Tanaka, K. Matsuda, C. Tanikawa, T. Mori, H. Nishimori, K. Tamai, T. Tokino, Y. Nakamura, and Y. Taya: p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell, 102:849-862, 2000

988

C. Larsson, B. Skogseid, K. Obeg, Y. Nakamura, M. Nordenskjold: Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature, 332:85-87, 1988

868

A. Suzuki, R. Yamada, X. Chang, S.Tokuhiro, T. Sawada, M. Suzuki, M. Nagasaki, M. Nakayama-Hamada, R.Kawaida, M. Ono, M. Ohtsuki, H. Furukawa, S. Yoshino, M. Yukioka, S. Touma, T. Matsubara, S. Wakitani, R. Teshima, A. Sekine, A.Iida, A. Takahashi, T. Tsunoda, Y. Nakamura, and K. Yamamoto: Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nature Genetics, 34:395-402, 2003

803

Y. Miyoshi, H. Nagase, H. Ando, A. Horii, S. Ichii, S. Nakatsuru, T. Aoki, Y. Miki, T. Mori and Y. Nakamura: Somatic mutation of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Human Molecular Genetics, 1:229-233, 1992

766

S. Satoh, Y. Daigo, Y. Furukawa, T. Katoh, N. Miwa, T. Nishiwaki, T. Kawasoe, H. Ishiguro, M. Fujita, T. Tokino, Y. Sasaki, S. Imaoka, M. Murata, T. Shimano, Y. Yamaoka, and Y. Nakamura: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nature Genetics, 24:245-250, 2000

764

The International Warfarin Pharmacogenetics Consortium: Estimation of the warfarin dose with clinical and pharmacogenetic data. New Eng. J. Med., 360:753-764, 2009

711

K. Ozaki, Y. Ohnishi, A. Iida, A. Sekine, R. Yamada, T. Tsunoda, H. Sato, H. Sato, M. Hori, Y. Nakamura, and T. Tanaka: Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction. Nature Genetics, 32:650-654, 2002

698

H. Tanaka, H. Arakawa, T. Yamaguchi, K. Shiraishi, S. Fukuda, K. Matsui, Y. Takei, and Y. Nakamura: A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint DNA damage. Nature, 404:42-49, 2000

673

D. Barker, E. Wright, K. Nguyen, L. Cannon, P. Fain, D. Goldger, D. T. Bishop, J. Carey, B. Bety, H. Willard, J. S. Waye, G. Greig, L. Leinward, Y. Nakamura, P. O'Connell, M. Leppert, J.-M. Lalouel, R. White and M. Skolnick: Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17. Science, 236:1100-1102, 1987

643

K.W. Kinzler, M.C. Nilbert, B. Vogelstein, T.M. Bryan, D.B. Levy, K.J. Smith, A.C. Preisinger, S.R. Hamilton, P. Hedge, A. Merkham, M. Carlson, G. Joslyn, J. Groden, R. White, Y. Miki, I. Nishisho and Y. Nakamura: Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science, 251:1366-1370, 1991

643

M. Leppert, M. Dobbes, P. Scambler, P. O'Connell, Y. Nakamura, D. Stauffer, S. Woodward, R. Burt, J. Hughes, E. Gardner, M. Lathrop, J. Wasumuth, J.-M. Lalouel, R. White: The gene for familial polyposis coli maps to the long arm of chromosome 5. Science, 238:1411-1413, 1987

592

K. Kobayashi, Y. Nakahori, M. Miyake, Y. Nomura, M. Yoshioka, K. Saito, M. Osawa, J. Goto, Y. Nakagome, I. Kanazawa, Y. Nakamura, K. Tokunaga, and T. Toda: An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy (FCMD). Nature, 394:388-392, 1998

575

R.A. Gatti, I. Berkel, E. Border, G. Braedt, P. Charmley, P. Concannon, F. Ersoy, T. Foroud, N.J.G. Jaspers, K. Lange, G.M. Lathrop, M. Leppert, Y. Nakamura, M. Paterson, W. Salser, O. Sanal, W. Shan, J. Silver, R.S. Sparkes, E. Susi, D. Weeks, R. White and F. Yoder: Localization of ataxia-telangiectasia gene to chromosome 11q22.3. Nature, 336:577-580, 1988

555

H. Okabe, S. Satoh, T. Kato, O. Kitahara, R. Yanagawa, Y. Yamaoka, T. Tsunoda, Y. Furukawa and Y. Nakamura: Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Research, 6:2129-2137, 2001

507

P. C. Sabeti, P. Varilly, B. Fry, J. Lohmueller, E. Hostetter, C. Cotsapas, X. Xie, E. H. Byrne, S. A. McCarroll, R. Gaudet, S. F. Schaffner, E. S. Lander, and The International HapMap Consortium: Genome-wide detection and characterization of positive selection in human populations. Nature, 449:913-918, 2007

504

T. Sato, A. Tanigami, K. Yamakawa, F. Akiyama, F. Kasumi, G. Sakamoto and Y. Nakamura: Allelotype of breast cancer: Cumulative allele losses promote tumor progression in primary breast cancer. Cancer Research, 50:7184-7189, 1990

493

H. Han, A. Yanagisawa, Y. Kato, J. Park, and Y. Nakamura: Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Research, 53:5087-5089, 1993

485

S. Tokuhiro, R. Yamada, X. Chang, A. Suzuki, Y. Kochi, T. Sawada, M. Suzuki, M. Nagasaki, M. Ohtsuki, M. Ono, H. Furukawa, M. Nagashima, S. Yoshino, A. Mabuchi, A. Sekine, S. Saito, A. Takahashi, T. Tsunoda, Y. Nakamura and K. Yamamoto: An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nature Genetics, 35:341-348, 2003

471

W. Satake, Y. Nakabayashi, I. Mizuta, Y. Hirota, C. Ito, M. Kubo, T. Kawaguchi, T. Tsunoda, M. Watanabe, A. Takeda, H. Tomiyama, K. Nakashima, K. Hasegawa, F. Obata, T. Yoshikawa, H. Kawakami, S. Sakoda, M. Yamamoto, N. Hattori, M. Murata, Y. Nakamura, and T. Toda: Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nature Genetics, 41:1303-1307, 2009

466

Y. Miyoshi, H. Ando, H. Nagase, I. Nishisho, A. Horii, Y. Miki, T. Mori, J. Utsunomiya, S. Baba, G. Petersen, S.R. Hamilton, K.W. Kinzler, B. Vogelstein, Y. Nakamura: Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients. Proc. Natl. Acad. Sci. USA, 89:4452-4456, 1992

450

The International Cancer Genome Consortium: International network of cancer genome projects. Nature, 464:993-998, 2010

403

T. Mizuguchi, G. Collod-Beroud, T. Akiyama, M. Abifadel, N. Harada, T. Morisaki, D. Allard, M. Varret, M. Claustres, H. Morisaki, M. Ihara, A. Kinoshita, K. Yoshiura, C. Junien, T. Kajii, G. Jondeau, T. Ohta, T. Kishino, Y. Furukawa, Y. Nakamura, N. Niikawa, C. Boileau, and N. Matsumoto: Heterozygous TGFBR2 mutations in Marfan syndrome. Nature Genetics, 36:855-860, 2004

401

Y. Miyoshi, K. Iwao, Y. Nagasawa, T. Aihara, Y. Sasaki, S. Imaoka, M. Murata, T. Shimano, and Y. Nakamura: Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Research, 58:2524-2527, 1998

400

K. Yasuda, K. Miyake, Y. Horikawa, K. Hara, H. Osawa, H. Furuta, Y. Hirota, H. Mori, A. Jonsson, Y. Sato, K. Yamagata, Y. Hinokio, H.-Y. Wang, T. Tanahashi, N. Nakamura, Y. Oka, N. Iwasaki, Y. Iwamoto, Y. Yamada, Y. Seino, H. Maegawa, A. Kashiwagi, J. Takeda, E. Maeda, H. D. Shin, Y. M. Cho, K. S. Park, H. K. Lee, M. C. Y. Ng, R. C. W. Ma, W.-Y. So, J. C. N. Chan, V. Lyssenko, T. Tuomi, P.Nilsson, L. Groop, N. Kamatani, A. Sekine, Y. Nakamura, K. Yamamoto, T. Yoshida, K. Tokunaga, M. Itakura, H. Makino, K. Nanjo, T. Kadowaki, and M. Kasuga: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nature Genetics, 40:1092-1097, 2008

387

R. Hamamoto, Y. Furukawa, M. Morita, Y. Iimura, F. P. Silva, M. Li, R. Yagyu and Y. Nakamura: SMYD3 encodes a novel histone methyltransferase involved in the proliferation of cancer cells. Nature Cell Biology, 6:731-740, 2004

386

S. Kern, E. Fearon, K.W.F. Tersmette, J.P. Enterline, M. Leppert, Y. Nakamura, R. White, B. Vogelstein and S. Hamilton: Allelic loss in colorectal carcinoma. JAMA, 261:3099-3103, 1989

381

K. Kasai, Y. Nakamura and R. White: Amplification of a VNTR locus (pMCT118) by the polymerase chain reaction (PCR) and its application to forensic science. J. Forensic Sci., 35:1196-1200, 1990

380

M. Leppert, E. Anderson, T. Quattlebaum, D. Stauffer, P. O'Connell, Y. Nakamura, J-M. Lalouel and R. White: Mapping of the seizure gene: Benign familial neonatal convulsions linked to genetic makers on chromosome 20. Nature, 337:647-648, 1989

377

N. Hayashi, I. Ito, A. Yanagisawa, Y. Kato, S. Nakamori, S. Imaoka, H. Watanabe, M. Ogawa, and Y. Nakamura: Genetic diagnosis of lymph-node metastasis in colorectal cancer. Lancet, 345:1257-1259, 1995

371

H. Unoki, A. Takahashi, T. Kawaguchi, K. Hara, M. Horikoshi, G. Andersen, D.P.K. Ng, J. Holmkvist, K. Borch-Johnsen, T. J. Rgensen, A. Sandbaek, T. Lauritzen, T. Hansen, S. Nurbaya, T. Tsunoda, M. Kubo, T. Babazono, H. Hirose, M. Hayashi, Y. Iwamoto, A. Kashiwagi, K. Kaku, R. Kawamori, E. S. Tai, O. Pedersen, N. Kamatani, T. Kadowaki, R. Kikkawa, Y. Nakamura, and S. Maeda: SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nature Genetics, 40:1098-1102, 2008

359

W. Cookson, R.P. Young, A.J. Sandford, M.F. Moffatt, T. Shirakawa, P.A. Sharp, J.A. Faux, C. Julier, R.A. Wells, P.N. Le Souef, Y. Nakamura, G.M. Lathrop and J.M. Hopkin: Maternal inheritance of atopic IgE responsiveness on chromosome 11q. Lancet, 340:381-384, 1992

356

K. Ono, T. Tanaka, T. Tsunoda, O. Kitahara, C. Kihara, A. Okamoto, K. Ochiai, T. Takagi, and Y. Nakamura: Identification by cDNA microarray of genes Involved in ovarian carcinogenesis. Cancer Research, 60:5007-5011, 2000

356

H. Nagase, and Y. Nakamura: Mutations of the APC (adenomatous polyposis coli) gene. Human Mutation, 2:425-434, 1993

355

H. Shibata, K. Toyama, H. Shioya, M. Ito, M. Hirota, S. Hasegawa, H. Matsumoto, H. Takano, T. Akiyama, K. Toyoshima, R. Kanamaru, Y. Kanegae, I. Saito, Y. Nakamura, K. Shiba, and T. Noda: Rapid colorectal adenoma formation initiated by conditional targeting of the APC gene. Science, 278:120-123, 1997

343

A. Tenesa, S.M. Farrington, J.G.D. Prendergast, M.E. Porteous, M. Walker, N. Haq, R.A. Barnetson, E. Theodoratou, R. Cetnarskyj, N. Cartwright, R. Wilson, C. Semple, A.J. Clarke, F.J.L. Reid, L.A. Smith, K. Kavoussanakis, T. Kossler, P.D.P. Pharoah, S. Buch, C. Schafmayer, J. Tepel, S. Schreiber, H. Volzke, C.O. Schmidt, J. Hampe, S. Wilkening, F. Canzian, J. Chang-Claude, M. Hoffmeister, H. Brenner, G. Capella, V. Moreno, I.J. Deary, J.M. Starr, I.P.M. Tomlinson, E. Webb, R.S. Houlston, G. Rennert, D. Ballinger, L. Rozek, S.B. Gruber, K. Matsuda, T. Kidokoro, Y. Nakamura, B.W. Zanke, C.M.T. Greenwood, J. Rangrej, R. Kustra, A. Montpetit, T.J. Hudson, S. Gallinger, H. Campbell, and M.G. Dunlop: A genome-wide association scan identifies colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nature Genetics, 40:631-637, 2008

342

T. Mori, K. Miura, T. Aoki, T. Nishihira, S. Mori, and Y. Nakamura: Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma. Cancer Research, 54:3396-3397, 1994

334

Y. Horio, Ta. Takahashi, T. Kuroishi, K. Hibi, M. Suyama, T. Niimi, K. Shimokata, K. Yamakawa, Y. Nakamura, R. Ueda, and To. Takahashi: Prognostic significance of p53 mutation and 3p deletion in primary resected non-small cell lung cancer. Cancer Research, 53:1-4, 1993

332

Y. Ohnishi, T. Tanaka, K. Ozaki, R. Yamada, H. Suzuki and Y. Nakamura: A high-throughput SNP typing system for genome-wide association studies. Journal of Human Genetics, 46:471-477, 2001

329

A.J. Sandford, T. Shirakawa, M.F. Moffatt, S.E. Daniels, C. Ra, J.A. Faux, R.P. Young, Y. Nakamura, G.M. Lathrop, W. Cookson and J.M. Hopkin: Localization of atopy and the βsubunit of high-affinity IgE receptor (FcERI) on chromosome 11q. Lancet, 341:332-334, 1993

323

M.H. Jones and Y. Nakamura: Detection of loss of heterozygosity at the human tp53 locus using a dinucleotide repeat polymorphism. Genes Chromosomes and Cancer, 5:89-90, 1992

319

O. Kitahara, Y. Furukawa, T. Tanaka, C. Kihara, K. Ono, R. Yanagawa, E. M. Nita, H. Ogasawara, J. Okutsu, H. Zenbutsu, N. Shiraishi, T. Takagi, Y. Nakamura, and T. Tsunoda: Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after laser-capture microdissection of tumor tissues and normal epithelia. Cancer Research, 61:3544-3549, 2001

315

Y. Miki, I. Nishisho, A. Horii, Y. Miyoshi, J. Utsunomiya, K. Kinzler, B. Vogelstein. Y. Nakamura: Disruption of the APC gene by retrotransposal insertion of L1 sequence in a colon cancer. Cancer Research, 52:643-645, 1992

314

H. Nagase, Y. Miyoshi, A. Horii, T. Aoki, M. Ogawa, J. Utsunomiya, S. Baba, T. Sasazuki and Y. Nakamura: Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis (FAP) patients. Cancer Research, 52:4055-4057, 1992

306

A. Bourdon, L. Minai, V. Serre, J.-P. Jais, E. Sarzi, S. Aubert, D. Chretien, P. de Lonlay, V. Paquis-Flucklinger, H. Arakawa, Y. Nakamura, A. Munnich, and A. Rotig: Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nature Genetics, 39:776-780, 2007

300

Total number of citations of all papers：>100,000

Publication lists: 1. Y. Miyake, Y. Nakamura, N. Takayama and K. Horiike: Alpha reduced nicotinamide adenine

dinucleotides-dependent reductase reactions of rat liver microsomes. Journal of Biochem., 78:773-783, 1975

2. T. Noguchi, H. Inoue, Y. Nakamura, H. Chen, K. Matsubara and T. Tanaka: Molecular cloning of cDNA sequences for rat M2-type pyruvate kinase and regulation of its mRNA. Journal of Biological Chemistry, 259:2651-2655, 1984

3. Y. Nakamura, M. Ogawa, T. Nishide, M. Emi, S. Himeno, G. Kosaki and K. Matsubara: Sequences of cDNAs for human salivary and pancreatic alpha-amylase. Gene, 28:263-270, 1984

4. K. Ishizaki, A. Noda, M. Ikenaga, K. Ida, K. Omoto, Y. Nakamura and K. Matsubara: Restriction fragment length polymorphism detected by human salivary amylase cDNA. Human Genetics, 71:261-262, 1985

5. T. Yamamoto, Y. Nakamura, T. Nishide, M. Emi, M. Ogawa, T. Mori and K. Matsubara: Molecular cloning and nucleotide sequence of human pancreatic secretory trypsin inhibitor (PSTI) cDNA. Biochemical and Biophysical Research Communications, 132:605-612, 1985

6. R. White, S. Woodward, M. Leppert, P. O'Connell, Y. Nakamura, M. Hoff, J. Herbst, J-M. Lalouel, M. Dean and G. Vande Woude: A closely linked genetic marker for cystic fibrosis. Nature, 318:382-384, 1985

7. T. Nishide, Y. Nakamura, M. Emi, T. Yamamoto, M. Ogawa, T. Mori and K. Matsubara: Primary structure of human salivary alpha-amylase gene. Gene, 41:299-304, 1986

8. M. Emi, Y. Nakamura, M. Ogawa, T. Yamamoto, T. Nishide, T. Mori and K. Matsubara: Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. Gene, 41:305-310, 1986

9. R. White, Y. Nakamura, C. Julier, A. Silva, P. O'Connell, M. Leppert, M. Lathrop and J.-M. Lalouel: Linkage Maps of Human Chromosomes. Current Communications in Molecular Biology "DNA Probes", :43-47, 1986

10. R. White, M. Leppert, P. O'Connell, Y. Nakamura, C. Julier, S. Woodward, A. Silva, R. Wolff, M. Lathrop and J.-M. Lalouel: Construction of Human Genetic Linkage Maps: I. Progress and perspectives. Cold Spring Harbor Symposia on Quantitative Biology Volume 51: Molecular Biology of Homo Sapiens, 51:29-38, 1986

11. Y. Nakamura, T. Sato, M. Emi, A. Miyanohara, T. Nishide and K. Matsubara: Expression of human salivary alpha-amylase gene in Saccharomyces cervisiae and its secretion using the mammalian signal sequence. Gene, 50:239-245, 1986

12. T. Sato, S. Tsunasawa, Y. Nakamura, M. Emi, F. Sakiyama and K. Matsubara: Expression of the human salivary alpha-amylase gene in yeast and characterization of the secreted protein. Gene, 50:247-257, 1986

13. R. White, M. Leppert, P. O'Connell, Y. Nakamura, S. Woodward, M. Hoff, J. Herbst, M. Dean, G. Vande Woude, M. Lathrop and J.-M. Lalouel: Further linkage data on cystic fibrosis: the Utah study. Am. J. Human Genetics, 39:694-698, 1986

14. Y. Nakamura, M. Leppert, P. O'Connell, Roger Wolff, T. Holm, M. Culver, C. Martin, E. Fujimoto, M. Hoff, E. Kumlin and R. White: Variable number of tandem repeat (VNTR) markers for human gene mapping. Science, 235:1616-1622, 1987

15. Y. Nakamura, C. Julier, R. Wolff, T. Holm, P. O'Connell, M. Leppert and R. White: Characterization of human "midisatellite" sequence. Nucleic Acids Research, 15:2537-2547, 1987

16. L. D. Keppen, M. F. Leppert, P. O'Connell, Y. Nakamura, D. Stauffer, M. Lathrop, J-M. Lalouel and R. White: Etiological heterogeneity in X-linked spastic paraplesia. Am. J. Human Genetics, 41:933-943, 1987

17. R. White, M. Leppert, P. O'Connell, Y. Nakamura, T. Holm, G.M. Lathrop and J-M. Lalouel: Linkage maps of human genes. Acuta Paediatrica Japonica, 29:482-488, 1987

18. D. Barker, E. Wright, K. Nguyen, L. Cannon, P. Fain, D. Goldger, D. T. Bishop, J. Carey, B. Bety, H. Willard, J. S. Waye, G. Greig, L. Leinward, Y. Nakamura, P. O'Connell, M. Leppert, J.-M. Lalouel, R. White and M. Skolnick: Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17. Science, 236:1100-1102, 1987

19. P. O'Connell, G.M. Lathrop, M. Law, M. Leppert, Y. Nakamura, M. Hoff, E. Kumlin, W. Thomas, T. Elsner, L. Ballard, P. Goodman, E. Azen, J.E. Sadler, G.Y. Cai, J.-M. Lalouel and R. White: A primary genetic linkage map for human chromosome 12. Genomics, 1:93-102, 1987

20. M. Leppert, M. Dobbes, P. Scambler, P. O'Connell, Y. Nakamura, D. Stauffer, S. Woodward, R. Burt, J. Hughes, E. Gardner, M. Lathrop, J. Wasumuth, J.-M. Lalouel, R. White: The gene for familial polyposis coli maps to the long arm of chromosome 5. Science, 238:1411-1413, 1987

21. R. White, Y. Nakamura, P. O'Connell, M. Leppert, M. Lathrop, J.-M. Lalouel, D. Barker, D. Goldgar, M. Skolnick, C. Mathew and B. Ponder: Tightly linked markers for the neurofibromatosis type1 gene. Genomics, 1:364-367, 1987

22. P. O'Connell, M. Leppert, Y. Nakamura, M. Dean, M. Park, G.V. Woude, M. Ferrall, B. Wainright, R. Williamson, M. Lathrop, J.-M. Lalouel and R. White: DNA markers for the cystic fibrosis locus. Genetics and Epithelial Cell Dysfunction in Cystic Fibrosis, Alan R. Liss Inc., :127-137, 1987

23. R.L. White, J.-M. Lalouel, G.M. Lathrop, M.F. Leppert, Y. Nakamura, and P. O’Connell: Mapping approaches to gene identification in humans. Western Journal of Medicine, 147:423-427, 1987

24. G.M. Lathrop, M. Farrall, P. O'Connell, M. Leppert, Y. Nakamura, N. Lench, H. Kruyer, M. Dean, M. Park, G. Vande Woude, J.-M. Lalouel, R. Williamson, R. White: Refined linkage map of chromosome 7 in the region of cystic fibrosis gene. Am. J. Human Genetics, 42:38-44, 1988

25. M. Lathrop, Y. Nakamura, P. Cartwright, P. O'Connell, M. Leppert, C. Jones, H. Tateishi, T. Bragg, J.M. Lalouel and R. White: A primary genetic map of markers for human chromosome 10. Genomics, 2:157-164, 1988

26. C. Larsson, B. Skogseid, K. Obeg, Y. Nakamura, M. Nordenskjold: Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature, 332:85-87, 1988

27. Y. Nakamura, M. Lathrop, M. Leppert, M. Dobbes, J. Wasumuth, E. Wolff, M. Carlson, E. Fujimoto, K. Krapcho, S. Woodward, R. Burt, J. Hughes, E. Gardner, J.-M. Lalouel and R. White: Localization of the genetic defect in familial adenomatous polyposis within a small region of chromosome 5. Am. J. Human Genetics, 43:638-644, 1988

28. Y. Nakamura, M. Lathrop, P. O'Connell, M. Leppert, D. Barker, E. Wright, M. Skolnick, S. Kondoleon, M. Litt, J.-M. Lalouel and R. White: A mapped set of DNA markers for human chromosome 17. Genomics, 2:302-309, 1988

29. Y. Nakamura, M. Lathrop, P. O'Connell, M. Leppert, J.-M. Lalouel and R. White: A primary map of 10 DNA markers and 2 serological markers for human chromosome 19. Genomics, 3:67-71, 1988

30. R.A. Lothe, Y. Nakamura, S. Woodward, T. Gedde-Dahl and R. White: VNTR(variable number of tandem repeats) markers show loss of chromosome 17p sequences in human colorectal carcinomas. Cytogenetics Cell Genetics, 48:167-169, 1988

31. B. Vogelstein, E.R. Fearon, S.R. Hamilton, S. Kern, A.C. Presinger, M. Leppert, Y. Nakamura, R. White, L. Smets and J.L. Bos: Genetic alterations during colorectal tumor development. New Eng. J. Med., 319:525-532, 1988

32. S. Chamberlain, J. Shaw, A. Rowland, J. Wallis, S. South, Y. Nakamura, A. von Gabain, M. Farrall and R. Williamson: Mapping of mutation causing Friedrich's ataxia to human chromosome 9. Nature, 334:248-250, 1988

33. Y. Nakamura, M. Lathrop, P. O'Connell, M. Leppert, J.-M. Lalouel and R. White: A mapped set of markers for human chromosome 15. Genomics, 3:342-346, 1988

34. Y. Nakamura, M. Carlson, K. Krapcho, M. Kanamori and R. White: A new approach for isolating VNTR markers. Am. J. Human Genetics, 43:854-859, 1988

35. Y. Nakamura, M. Lathrop, T. Bragg, C. Jones, P. O'Connell, M. Leppert, J.-M. Lalouel and R. White: An extended linkage map for human chromosome 10. Genomics, 3:389-392, 1988

36. M. Lathrop, Y. Nakamura, P. O'Connell, M. Leppert, S. Woodward, J.-M. Lalouel and R. White: A mapped set of genetic markers for human chromosome 9. Genomics, 3:361-366, 1988

37. R.A. Gatti, I. Berkel, E. Border, G. Braedt, P. Charmley, P. Concannon, F. Ersoy, T. Foroud, N.J.G. Jaspers, K. Lange, G.M. Lathrop, M. Leppert, Y. Nakamura, M. Paterson, W. Salser, O. Sanal, W. Shan, J. Silver, R.S. Sparkes, E. Susi, D. Weeks, R. White and F. Yoder: Localization of ataxia-telangiectasia gene to chromosome 11q22.3. Nature, 336:577-580, 1988

38. P. vanTuinen, W. B. Dobyns, D. C. Rich, K. M. Summers, T. J. Robinson, Y. Nakamura and D. Ledbetter: Molecular detection of microscopic and submicroscopic deletions associated with Miller-Dieker syndrome. Am. J. Human Genetics, 43:587-596, 1988

39. R. Wolff, Y. Nakamura and R. White: Molecular characterization of a spontaneously generated new allele at a VNTR locus. Genomics, 3:347-351, 1988

40. P. O'Connell, M. Lathrop, M. Leppert, Y. Nakamura, U. Muller, J.-M. Lalouel and R White: Twelve loci form a continuous linkage map for human chromosome 18. Genomics, 3:367-372, 1988

41. P. O'Connell, G.M. Lathrop, Y. Nakamura, M.L. Leppert, R.H. Ardinger, J.L. Murray, J-M. Lalouel and R. White: Twenty-eight loci form a continuous linkage map of markers for human chromosome 1. Genomics, 4:12-20, 1989

42. Y. Nakamura, M. Lathrop, P. O'Connell, M. Leppert, J.M. Lalouel and R. White: Frequent recombination was observed in the distal end of the long arm of human chromosome 14. Genomics, 4:76-81, 1989

43. R. Fujita, A. Seck, Y. Agid, C. Tommasi-Davenas, P. Trouillas, A. J. Driesel, K. Olek, Y. Nakamura, J. L. Mandel and A. Hanauer: Confirmation of linkage of Friedrich ataxia to chromosome 9 and identification of a new closely linked marker. Genomics, 4:110-111, 1989

44. W. Byerley, J.-M. Lalouel, C. Mellon, Y. Nakamura, P. O'Connell, M. Leppert and R. White: Mapping genes for manic-depression and schizophrenia with DNA markers. Neuroscience, 12:46-48, 1989

45. R.M. Landsvater, C.P.G. Mathew, B.A. Smith, E.M. Marcus, G.J. te Meerman, C.J.M. Lips, R.A. Geerink, Y. Nakamura, B.A.J. Ponder, C.H.C.M. Buys: Development of multiple endocrine neoplasia type 2A does not involve substantial deletions of chromosome 10. Genomics, 4:246-250, 1989

46. J. Toguchida, K. Ishizaki, M.S. Sasaki, Y. Nakamura, M. Ikenaga, M. Kato, M. Sugimoto, Y. Kotoura and T. Yamamoto: Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma. Nature, 338:156-158, 1989

47. M. Fujimoto, D. Fults, G. Thomas, Y. Nakamura, M. P. Heilbrun, R. White, J. L. Story, S. L. Naylor, K. S. Kagen-Hallet and P. J. Sheridan: Loss of heterozygosity on chromosome 10 in human glioblastoma multiforme. Genomics, 4:210-214, 1989

48. M. Leppert, E. Anderson, T. Quattlebaum, D. Stauffer, P. O'Connell, Y. Nakamura, J-M. Lalouel and R. White: Mapping of the seizure gene: Benign familial neonatal convulsions linked to genetic makers on chromosome 20. Nature, 337:647-648, 1989

49. Y. Nakamura, C.P.G. Mathew, H. Sobol, D.F. Easton, H. Telenius, T. Bragg, K. Chin, J. Clark, C. Jones, G.M. Lonoir, R. White and B.A.J. Ponder: Linked markers flanking the gene for multiple endocrine neoplasia type 2A. Genomics, 5:199-203, 1989

50. Y. Nakamura, N. Tomita, T. Nishide, M. Emi, A. Horii, M. Ogawa, T. Mori, G. Kosaki, T. Okabe, M. Fujisawa, N. Ohsawa, T. Kameya and K. Matsubara: Production of salivary type alpha-amylase in human lung cancer. Gene, 77:107-112, 1989

51. K. Tory, H. Brauch, M. Linehan, E. Oldfield, D. Barba, M. Filling-Katz, Y. Nakamura, R. White, B. Seizinger, M.I. Lerman and B. Zbar: Specific genetic change in tumors associated with von Hippel-Lindau disease. J. Natl. Cancer Inst., 81:1097-1101, 1989

52. Y. Nakamura, C. Larsson, C. Julier, B. Skogseid, S. Wells, K. Oberg, M. Carlson, P. O'Connell, M. Leppert, J.-M. Lalouel, M. Nordenskjold and R. White: Localization of the genetic defect in multiple endocrine neoplasia type 1 within a small region of chromosome 11. Am. J. Human Genetics, 44:751-755, 1989

53. L.A. Lothe, S.D. Fossa, A.E. Stenwig, Y. Nakamura, R. White, A.-L. Borresen and A. Brogger: Loss of 3P or 11 alleles is associated with testicular tumors. Genomics, 5:134-138, 1989

54. B. Vogelstein, E.R. Fearon, S.E. Kern, S.R. Hamilton, A.C. Preisinger, Y. Nakamura and R. White: Allelotype of colorectal carcinomas. Science, 244:207-211, 1989

55. S.J. Baker, E.R. Fearon, J.M. Nigro, S.R. Hamilton, A.C. Preisinger, J.M. Jessup, P. vanTuinen, D.H. Ledbetter, D.F. Barker, Y. Nakamura, R. White and B. Vogelstein: Chromosome 17 Deletions and p53 mutations in Colorectal Carcinomas. Science, 244:217-221, 1989

56. P. O'Connell, G.M. Lathrop, Y. Nakamura, M.L. Leppert, J.-M. Lalouel and R. White: Twenty loci form a continuous linkage map of markers for human chromosome 2. Genomics, 5:738-745, 1989

57. G.M. Lathrop, P. O'Connell, M. Leppert, Y. Nakamura, M. Farrall, L.-C. Tsui, J.-M. Lalouel and R. White: Twenty-five loci form a continuous linkage map of markers for human chromosome 7. Genomics, 5:866-873, 1989

58. P.G. Ashton-Richkardt, M.G. Dunlop, Y. Nakamura, R.G. Morris, C.A. Purdie, C.M. Steel, H.J. Evans, C.C. Bird and A.H. Wyllie: High frequency of APC loss in sporadic colorectal carcinoma due to breaks clustered in 5q21-22. Oncogene, 4:1169-1174, 1989

59. Y. Nakamura, M. Leppert, P. O'Connell, M. Lathrop, J.-M. Lalouel and R. White: A genetic linkage map of markers for human chromosome 20. Genomics, 5:945-947, 1989

60. D. Ledbetter, S. Ledbetter, P. vanTuinen, K. Summers, T. Robinson, Y. Nakamura, R. Wolff, R. White, D. Barker, M. Wallace, F. Collins and W. Dobyns: Molecular dissection of a contiguous gene syndrome: Frequent submicroscopic deletions, evolutionarily conserved sequences, and a hypomethylated "island" in the Miller-Dieker chromosome region. Proc. Natl. Acad. Sci. USA, 86:5136-5140, 1989

61. H. Sobol, S. Narod, Y. Nakamura, A. Bonue, C. Calmettes, D. Chadenas, G.Charpentier, J. Chatal, N. Delepine, M. Delisle, J. Dupond, P. Gardet, H. Godefroy, P. Guillausseau, C. Sholer, C. Houdent, J. Lalau, G. Mace, C. Parmentier, F. Soubrier, J. Tourniaire and G. Lenoir: Screening for multiple endocrine neoplasia type 2a with DNA-polymorphism analysis. New Eng. J. Med., 321:996-1001, 1989

62. E. Friedman, K. Sakaguchi, A. Bale, A. Falchetti, E. Streeten, M. Zimering, L. Wenstein, W. McBride, Y. Nakamura, M. Brandi, J. Norton and G. Aurbach: Clonality of parathyroid tumors in familial multiple endocrine neoplasia type1. New Eng. J. Med., 321:213-218, 1989

63. R. Gatti, Y. Nakamura, M. Nussmeier, E. Susi, W. Shan and W. Grody: Informativeness of VNTR genetic markers for detecting chimerism after bone marrow transplantation. Disease Markers, 7:105-112, 1989

64. T. Sato, H. Uemura, Y. Izumoto, J. Nakao, Y. Nakamura, and K. Matsubara: The conformation of mature human alpha-amylase conditions its secretion from yeast. Gene, 83:355-365, 1989

65. G.I. Bell, J. Murray, Y. Nakamura, T. Kayano, R. Eddy, Y.-S. Fan, M. Byers and T. Shows: Polymorphic human insulin-responsive glucose-transporter gene on chromosome 17p13. Diabetes, 38:1072-1075, 1989

66. J. Toguchida, K. Ishizaki, Y. Nakamura, M. Sasaki, M. Ikenaga, M. Kato, M. Sugimoto, Y. Kotoura, and T. Yamamoto: Assignment of common allele loss in osteosarcoma to the subregion 17p13. Cancer Research, 49:6247-6251, 1989

67. B. Nelkin, Y. Nakamura, R. White, A. Bustros, J. Herman, S. Wells and S. Baylin: Low incidence of loss of chromosome 10 in sporadic and hereditary human medullary thyroid carcinoma. Cancer Research, 49:4114-4119, 1989

68. R. Korneluk, A. MacKenzie, Y. Nakamura, I. Dube, P. Jacob and A. Hunter: A reordering of human chromosome 19 long-arm DNA markers flanking the myotonic dystrophy locus. Genomics, 5:596-604, 1989

69. B. Ponder, B. Smith, E. Marcus, Y. Nakamura, R. Landsvater. C. Buys and c. Mathew: Genetic Events in tumorigenesis in multiple endocrine neoplasia type 2. Cancer Cells, 7:219-221, 1989

70. M. El-Azouzi, R. Chung, G. Farmer, R. Martuza, P. Black, G. Rouleau, C. Hettlich, E. Hedley-Whyte, N. Zervas, K. Panagopoulos, Y. Nakamura, J. Gusella and B. Seizinger: Loss of distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human astrocytomas. Proc. Natl. Acad. Sci. USA, 86:7186-7190, 1989

71. S.J. Odelberg, R. Plaetke, J.R. Eldridge, L. Ballard, P. O'Connell, Y. Nakamura, M. Leppert, J.-M. Lalouel and R. White: Characterization of eight VNTR loci by agarose gel electrophoresis: Implications for parentage testing and forensic individualization. Genomics, 5:915-924, 1989

72. S.A. Narod, H. Sobol, Y. Nakamura, C. Calmettes, J.-L. Baulieu, J.-C. Bigorgne, G. Chabrier, J. Couette, J.-L. Gennes, J. Duprey, P. Gardet, P.-J. Guillausseau, D. Guilloteau, C. Houdent, J. Lefebvre, E. Modigliani, C. Parmentier, M. Pugeat, C. Siame, J. Tourniaire, J.-C. Vandroux, J.-M. Vinot, G.M. Lenoir: Linkage analysis of hereditary thyroid carcinoma with and without pheochromocytoma. Human Genetics, 83:353-358, 1989

73. D. Fults, R. Tippets, G.A. Thomas, Y. Nakamura and R. White: Loss of heterozygosity for loci on chromosome 17p in human malignant astrocytoma. Cancer Research, 49:6572-6577, 1989

74. D. Fults, P.F. Maness, Y. Nakamura and R. White: The N-ras oncogene is activated in a human medulloblastoma cell line. Brain Research, 503:281-287, 1989

75. S. Kern, E. Fearon, K.W.F. Tersmette, J.P. Enterline, M. Leppert, Y. Nakamura, R. White, B. Vogelstein and S. Hamilton: Allelic loss in colorectal carcinoma. JAMA, 261:3099-3103, 1989

76. R. White, J.-M. Lalouel, M. Leppert, M. Lathrop, Y. Nakamura and P. O'Connell: Linkage maps of human chromosomes. Genome, 31:1066-1072, 1989

77. HR. Chang, M. Scik., K. Ishizaki, M. S. Sasaki, J. Toguchida, M. Kato, M. Pharm, Y. Nakamura, S. Kawamura, T. Moriguchi, M. Ikenaga: Somatic mosaicism for DNA repair capacity in fibroblasts derived from a group a xeroderma pigmentosum patinent. The Journal of Investigative Dematology, 93:460-465, 1989

78. H. Telenius, C.P.G. Mathew, Y. Nakamura, D.F. Easton, J. Clark, H.P.N. Neumann, W.H. Ziegler, A. Schinzel and B.A.J. Ponder: Application of linked DNA markers to screening families with multiple endocrine neoplasia type 2A. Eur. J. Sug. Oncology, 16:134-140, 1990

79. M.H. Hofker, S. Smith, Y. Nakamura, I. Teshima, R. White and D. Cox: Physical mapping of probes within 14q32, a subtelomeric region showing a high recombination frequency. Genomics, 6:33-38, 1990

80. M. Smith, S. Malley, R. Cantor, M. Pandolfo, M. Gomes, R. Baumann, P. Flodman, K. Yoshiyama, Y. Nakamura, C. Julier, K. Dumars, J. Haines, J. Trofatter, M.A. Spence, D. Weeks and M. Conneally: Mapping of a gene determining tuberous sclerosis to human chromosome 11q14-11q23. Genomics, 6:105-114, 1990

81. C. Julier, Y. Nakamura, M. Lathrop, P. O'Connell, M. Leppert, T. Mohandas, J.-M. Lalouel and R. White: A primary map of 24 loci on human chromosome 16. Genomics, 6:419-427, 1990

82. R.L. White, J.-M. Lauloel, Y. Nakamura, H.D.-Keller, P Green, D.W. Bowden, C.G.P. Mathew, D.F. Easton, E.B. Robson, N.E. Morton, J.F.Gusella, J.L. Haines, A.E. Retief, K.K. Kidd, J.C. Murray, G.M. Lathrop and H.M. Cann: The CEPH consortium primary linkage map of human chromosome 10. Genomics, 6:393-412, 1990

83. M. Leppert, R. Burt, J. Hughes, W. Samowitz, Y. Nakamura, S. Woodward, E. Gardner, J. Lalouel and R. White: Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps. New Eng. J. Med., 322:904-908, 1990

84. P. Patel, B. Franco, C. Garcia, S. A. Slaugenhaupt, Y. Nakamura, D. Ledbetter, A. Chakravarti and J. R. Lapski: Genetic mapping of autosomal dominant Charcot-Marie-Tooth disease in a large French-Acadian kindred: identification of new linked markers on chromosome 17. Am. J. Human Genetics, 46:801-809, 1990

85. J.C. Murray, D.Y. Nishimura, K.H. Buetow, H.H. Ardinger, M.A. Spence, R.S. Sparkes, R.E. Falk, P.M. Falk, R.J. Gardner, E.M. Harkness, L.P. Glinski, R.M. Pauli, Y. Nakamura, P.P. Green and A. Schinzel: Linkage of an autosomal dominant clefting syndrome (Van der Woude) to loci on chromosome 1q. Am. J. Human Genetics, 46:486-491, 1990

86. R. White, Y. Nakamura, P. O'Connell, M. Leppert and J-M. Lalouel: Mapping genetic defects by linkage studies in families: A strategy for finding genes associated with cancer syndromes. Genetic Mechanisms in Carcinogenesis and Tumor Progression, :153-161, 1990

87. G.G. Germino, N.J. Barton, J. Lamb, K.R. Higgs, P. Harris, G.H. Xiao, G. Scherer, Y. Nakamura and S.T. Reeder: Identification of a locus which shows no genetic recombination with the autosomal dominant polycystic kidney disease gene on chromosome 16. Am. J. Human Genetics, 46:925-933, 1990

88. J. Groden, Y. Nakamura and J. German: Bloom syndrome: Molecular evidence that homologous recombination occurs in proliferating somatic cells. Proc. Natl. Acad. Sci. USA, 87:4315-4319, 1990

89. K. Ishizaki, M. Oshimura, M.S. Sasaki, Y. Nakamura and M. Ikenaga: Human chromosome 9 can complement UV sensitivity of xeroderma pigmentosum group a cells. Mutation Research, 235:209-215, 1990

90. C.G.P. Mathew, W. Wakiling, E. Jones, D. Easton, R. Fisher, C. Strong, B. Smith, K. Chin, P. Little, Y. Nakamura, T.B. Shows, C. Jones, P.J. Goodfellow, S. Povey and B.A.J. Ponder: Regional localization of polymorphic markers on chromosome 10 by physical and genetic mapping. Annals Human Genetics, 54:121-129, 1990

91. C. Julier, B. Gouyon, M. Jeorges, J.L. Guenet, Y. Nakamura, P. Avner and M. Lathrop: Minisatellite linkage maps in the mouse by cross-hybridization with human probes containing tandem repeats. Proc. Natl. Acad. Sci. USA, 87:4585-4589, 1990

92. G.M. Petersen, J. Brown, X. Bu, R.S. Sparkers and Y. Nakamura: Genetic linkage study of juvenile polyposis: Preliminary analysis. Hereditary colorectal cancer, :423-430(432?), 1990

93. M. Leppert, Y. Nakamura, R. Burt, J.P. Hughes, W. Samowitz, S. Woodward, E. Gardner, J.-M. Lalouel and R. White: Genetic mapping and allelic heterogeneity of the familial polyposis gene. Hereditary colorectal cancer, :27-36, 1990

94. A.H. Wyllie, P. Ashton-Rickardt, M.G. Dunlop, Y. Nakamura, J. Piris, C. Purdie, C.M. Steel and C.C. Bird: Status of the APC gene in familial and sporadic colorectal tumours as determined by closely flanking markers. Hereditary colorectal cancer, :453-456, 1990

95. Y. Nakamura, J. Wasmuth and R. White: Searching the gene responsible to familial polyposis coli(FAP). Hereditary colorectal cancer, :469-472, 1990

96. Y. Nakamura, R.L. White: Summary of chapter 7: Cytomolecular aspects of colorectal cancer. Hereditary colorectal cancer, :475-476, 1990

97. R. White, M. Leppert, Y. Nakamura, P. O'Connell, M. Lathrop and J.-M. Lalouel: Mapping genes that cause disease. The cellular and molecular biology of human carcinogenesis, :61-77, 1990

98. Y. Nakamura:, Clinical application of restriction fragment length polymorphisms (RFLPs). Automation and new technology in the clinical laboratory, :131-137, 1990

99. C. Julier, Y. Nakamura, M. Lathrop, P. O'Connell, M. Leppert, M. Litt, T. Mohandas, J.-M. Lalouel and R. White: A detailed genetic map of the long arm of chromosome 11. Genomics, 7:335-345, 1990

100. H. Shibuya, M. Yoneyama, Y. Nakamura, H. Harada, M. Hatakeyama, S. Minamoto, T. Kono, T. Doi, R. White, and T. Taniguchi: The human interleukin-2 receptor β-chain gene: genomic organization, promoter analysis and chromosomal assignment. Nucleic Acids Research, 18:3697-3703, 1990

101. K.H. Buetow, D. Nishimura, P. Green, Y. Nakamura, O. Jiang and J.C. Murray: A detailed multipoint gene map of chromosome 1q. Genomics, 8:13-21, 1990

102. K. Kasai, Y. Nakamura and R. White: Amplification of a VNTR locus (pMCT118) by the polymerase chain reaction (PCR) and its application to forensic science. J. Forensic Sci., 35:1196-1200, 1990

103. D.M. Eccles, G. Cranston, C.M. Steel, Y. Nakamura, and R.C.F. Leonard: Allele losses on chromosome 17 in human epithelial ovarian carcinoma. Oncogene, 5:1599-1601, 1990

104. T. Sato, A. Tanigami, K. Yamakawa, F. Akiyama, F. Kasumi, G. Sakamoto and Y. Nakamura: Allelotype of breast cancer: Cumulative allele losses promote tumor progression in primary breast cancer. Cancer Research, 50:7184-7189, 1990

105. M. Miyaki, M.Seki, M. Okamoto, A. Yamanaka, Y. Maeda, K. Tanaka, R. Kikuchi, T. Iwama, T. Ikeuchi, A. Tonomura, Y. Nakamura, R. White, Y. Miki, J. Utsunomiya and M. Koike: Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis. Cancer Research, 50:7166-7173, 1990

106. J.R. Batanian, S. Ledbetter, R. Wolff, Y. Nakamura, R. White, W. Dobyns and D. Ledbetter: Rapid diagnosis of Miller-Dieker syndrome and isolated lissencephaly sequence by the polymerase chain reaction. Human Genetics, 85:555-559, 1990

107. M.G. Dunlop, A.W. Wyllie, Y. Nakamura, C.M. Steel, H.J. Evans, R. White and C.C. Bird: Genetic linkage map of six polymorphic DNA markers around the gene for familial adenomatous polyposis on chromosome 5. Am. J. Human Genetics, 47:982-987, 1990

108. M. Okamoto, C. Sato, Y. Kohno, T. Mori, T. Iwama, A. Tonomura, Y. Miki, J. Utsunomiya, Y. Nakamura, R. White and M. Miyaki: Molecular nature of chromosome 5q loss in colorectal tumors and desmoids from patients with familial adenomatous polyposis. Human Genetics, 85:595-599, 1990

109. P. Patel, S. O'Rahilly, V. Buckle, Y. Nakamura, R.C. Turner and J.S. Wainscoat: Chromosome 11 allele loss in sporadic insulinoma. J. Clin. Pathol., 43:377-378, 1990

110. C. Coles, A.M. Thompson, P.A. Elder, B.B. Cohen, I.M. Mackenzie, G. Cranston, U. Chetty, J. Mackay, M. Macdonald, Y. Nakamura, B. Hoyheim and C.M. Steel: Evidence implicating at least two genes on chromosome 17p in breast carcinogenesis. Lancet, 336:761-763, 1990

111. T. Tokino, E. Takahashi, M. Mori, A. Tanigami, T. Glaser, J.W. Park, C. Jones, T. Hori and Y. Nakamura: Isolation and mapping of 62 new RFLP markers on human chromosome 11. Am. J. Human Genetics, 48:258-268, 1991

112. C.G.P. Mathew, D.F. Easton, Y. Nakamura and B.A.J. Ponder: Presymptomatic screening for multiple endocrine neoplasia type 2A with linked DNA markers. Lancet, 337:7-11, 1991

113. M. Fujimori, T. Tokino, O. Hino, T. Kitagawa, T. Imamura, E. Okamoto, M. Mitsunobu, T. Ishikawa, H. Nakagama, H. Harada, M. Yagura, K. Matsubara and Y. Nakamura: Allelotype study of primary

hepatocellular carcinoma. Cancer Research, 51:89-93, 1991 114. R. Morita, J. Ishikawa, M. Tsutsumi, K. Hikiji, Y. Tsukada, S. Kamidono, S. Maeda and Y.

Nakamura: Allelotype of renal cell carcinoma. Cancer Research, 51:820-823, 1991 115. K. Yamakawa, E. Takahashi, H. Saito, T. Sato, M. Oshimura, T. Hori and Y. Nakamura: Isolation

and mapping of 75 new DNA markers on human chromosome 3. Genomics, 9:536-543, 1991 116. K.W. Kinzler, M.C. Nilbert, B. Vogelstein, T.M. Bryan, D.B. Levy, K.J. Smith, A.C. Preisinger, S.R.

Hamilton, P. Hedge, A. Merkham, M. Carlson, G. Joslyn, J. Groden, R. White, Y. Miki, I. Nishisho and Y. Nakamura: Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science, 251:1366-1370, 1991

117. T. Sano, T. Tsujino, K. Yoshida, H. Nakayama, K. Haruma, H. Ito, Y. Nakamura, G. Kajiyama and E. Tahara: Frequent loss of heterozygosity on chromosome 1q, 5q and 17p in human gastric carcinomas. Cancer Research, 51:2926-2931, 1991

118. G. Petersen, J. Slack and Y. Nakamura: Screening guidelines and premorbid diagnosis of familial adenomatous polyposis using linkage. Gastroenterology, 100:1658-1664, 1991

119. K.H. Buetow, R. Shiang, P. Yang, Y. Nakamura, G.M. Lathrop, R. White, J.J. Wasmuth, S. Wood, L.D. Berdahl, N.J. Leysens, T.M. Ritty, M.E. Wise, and J.C. Murray: A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates. Am. J. Human Genetics, 48:911-925, 1991

120. P.G. Ashton-Richkardt, A.H. Wyllie, C.C. Bird, M.G.Dunlop, C.M. Steel, R.G. Morris, J. Piris, P. Romanowski, R.Wood, R. White, and Y. Nakamura: MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer. Oncogene, 6:1881-1886, 1991

121. Y. Miki, I. Nishisho, Y. Miyoshi, A. Horii, H. Ando, T. Nakajima, J. Utsunomiya and Y. Nakamura: Frequent loss of heterozygosity at the MCC locus on chromosome 5q21-22 in sporadic colorectal carcinomas. Japanese Journal of Cancer Research, 82:1003-1007, 1991

122. K. Yamakawa, R. Morita, E. Takahashi, T. Hori, J. Ishikawa, and Y. Nakamura: A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma. Cancer Research, 51:4707-4711, 1991

123. T. Sato, H. Saito, R. Morita, S. Koi, Je H. Lee, and Y. Nakamura: Allelotype of human ovarian cancer. Cancer Research, 51:5118-5122, 1991

124. K. Yamakawa, R. Morita, E. Takahashi, M. Lathrop, and Y. Nakamura: A genetic linkage map of 41 RFLP markers for human chromosome 3. Genomics, 11:565-572, 1991

125. K.W. Kinzler, M.C. Nilbert, L. Su, B. Vogelstein, T.M. Bryan, D.B. Levy, K.J. Smith, A.C. Preisinger, P. Hedge, D. McKechnie, R. Finniear, A. Markham, J. Groffen, M.S. Boguski, S.F. Alschul, A. Horii, H. Ando, Y. Miyoshi, Y. Miki, I. Nishisho, Y. Nakamura: Identification of FAP locus genes from chromosome 5q21. Science, 253:661-665, 1991

126. I. Nishisho, Y. Nakamura, Y. Miyoshi, Y. Miki, H. Ando, A. Horii, K. Koyama, J. Utsunomiya, S. Baba, P. Hedge, A. Markham, A.J. Krush, G. Petersen, S.R. Hamilton, M.C. Nilbert, D.B. Levy, T.M. Bryan, A.C. Preisinger, K.J. Smith, L. Su, K.W. Kinzler, and B. Vogelstein: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science, 253:665-669, 1991

127. R. Morita, S. Saito, J. Ishikawa, O. Ogawa, O. Yoshida, K. Yamakawa, Y. Nakamura: Common regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma. Cancer Research, 51:5817-5820, 1991

128. S. Itoh, H. Harada, Y. Nakamura, R. White, T. Taniguchi: Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23-q31. Genomics, 10:1097-1099, 1991

129. T. Sato, F. Akiyama, G. Sakamoto, F. Kasumi, Y. Nakamura: Accumulation of genetic alterations and progression of primary breast cancer. Cancer Research, 51:5794-5799, 1991

130. M. Janson, C. Larsson, B. Werelius, C Jones, T. Glaser, Y. Nakamura, C. Peter Jones, M. Nordenskjold: Detailed physical map of human chromosomal region 11q12-13 shows high meiotic recombination rate around the MEN1 locus. Proc. Natl. Acad. Sci. USA, 88:10609-10613, 1991

131. BR Seizinger, H.P. Klinger, C. Junien, Y. Nakamura, M. Le Beau, W. Cavenee, B. Emanuel, B. Ponder, S. Naylor, F. Mitelman, D. Louis, A. Menon, I. Newsham, J. Decker, M. Kaelbling, I. Henry, Av. Deimling: Report of the committee on chromosome and gene loss in human neoplasia Cytogenetic and Genome Research, 58:1080-1096, 1991

132. Y. Miki, I. Nishisho, Y. Miyoshi, J. Utsunomiya, Y. Nakamura: Interstitial loss of the same region of 5q in multiple adenomas and a carcinoma derived from adenomatous polyposis coli (APC) patient. Genes Chromosomes and Cancer, 4:81-83, 1992

133. M. Thangavelu, W. Neuman, R. Espinosa, Y. Nakamura, C.A. Westbrook, M. M. Le Beau: A physical and genetic linkage map of the distal long arm of chromosome 5. Cytogenetics Cell Genetics, 59:27-30, 1992

134. S. Saito, K. Okui, T. Tokino, M. Oshimura, Y. Nakamura: Isolation and mapping of 68 RFLP markers on human chromosome 6. Am. J. Human Genetics, 50:65-70, 1992

135. A. Tanigami, T. Tokino, S. Takiguchi, M. Mori, T. Glaser, J.W. Park, C. Jones, Y. Nakamura: Mapping of 262 DNA markers into 24 intervals on human chromosome 11. Am. J. Human Genetics, 50:56-64, 1992

136. T. Tokino, T. Imai, A. Tanigami, S. Takiguchi, Y. Nakamura: Physical mapping of a 950-kb region

surrounding a locus (D10S102) tightly linked to the MEN2A gene. Genomics, 12:394-400, 1992 137. T. Tokino, S. Takiguchi, A. Tanigami, T. Bragg, C. Jones, Y. Nakamura: 31 new RFLP systems

detected by 24 DNA markers on human chromosome 10. Genomics, 12:401-402, 1992 138. M. Fujimori, S. A. Wells Jr, Y. Nakamura: Fine-scale mapping of the gene responsible for multiple

endocrine neoplasia type 1 (MEN1). Am. J. Human Genetics, 50:399-403, 1992 139. K. Hibi, T. Takahashi, K. Yamakawa, R. Ueda, Y. Sekido, Y. Ariyoshi, M. Suyama, H. Takagi, Y.

Nakamura, T. Takahashi: Three distinct regions involved in 3p deletion in human lung cancer. Oncogene, 7:445-449, 1992

140. Y. Miyoshi, I. Nishisho, Y. Miki, T. Mori, K. Kinzler, B. Vogelstein, Y. Nakamura: Insertion/deletion polymorphism and other restriction fragment length polymorphisms in the MCC gene. Japanese Journal of Cancer Research, 83:10-14, 1992

141. S. Yokoyama, K. Yamakawa, E. Tsuchiya, M. Murata, S. Sakiyama, Y. Nakamura: Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma and adenocarcinoma of the lung. Cancer Research, 52:873-877, 1992

142. Y. Miki, I. Nishisho, A. Horii, Y. Miyoshi, J. Utsunomiya, K. Kinzler, B. Vogelstein. Y. Nakamura: Disruption of the APC gene by retrotransposal insertion of L1 sequence in a colon cancer. Cancer Research, 52:643-645, 1992

143. M. Mori, T. Tokino, A. Yanagisawa, M. Kanamori, Y. Kato, Y. Nakamura: Association between 11q13 amplification and prognosis of patients with oesophageal carcinomas. Europian Journal of Cancer, 28:755-757, 1992

144. A. Tanigami, T. Tokino, K. Takita, S. Takiguchi, Y. Nakamura: A 14-mb physical map of the region at chromosome 11q13 harboring the MEN1 locus and the tumor amplicon region (TAR). Genomics, 13:16-20, 1992

145. T. Hori, E. Takahashi, A. Tanigami, T. Tokino, Y. Nakamura: A high-resolution cytogenetic map of 168 cosmid DNA markers for human chromosome 11. Genomics, 13:129-133, 1992

146. H. Takayama, T. Suzuki, H. Mugishima, T. Fujisawa, M. Ookuni, M. Schwab, M. Gehring, Y. Nakamura, T. Sugimura, M. Terada and J. Yokota: Deletion mapping of chromosome 14q and 1p in human neuroblastoma. Oncogene, 7:1185-1189, 1992

147. Y. Miyoshi, H. Ando, H. Nagase, I. Nishisho, A. Horii, Y. Miki, T. Mori, J. Utsunomiya, S. Baba, G. Petersen, S.R. Hamilton, K.W. Kinzler, B. Vogelstein, Y. Nakamura: Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients. Proc. Natl. Acad. Sci. USA, 89:4452-4456, 1992

148. M.H. Jones, and Y. Nakamura: Detection of loss of heterozygosity at the human tp53 locus using a dinucleotide repeat polymorphism. Genes Chromosomes and Cancer, 5:89-90, 1992

149. A. Tanigami, T. Tokino, K. Takita, M. Ueda, F. Kasumi, Y. Nakamura: Detailed analysis of an amplified region at chromosome 11q13 in malignant tumors. Genomics, 13:21-24, 1992

150. T. Yamaguchi, J. Toguchida, Y. Nakamura, T. Yamamuro, Y. Kotoura, N. Takada, N. Kawaguchi, Y. Kaneko, M. S. Sasaki, K. Ishizaki: Allelotype analysis in osteosarcomas ; Frequent allele loss on 3q, 13q, 17p and 18q. Cancer Research, 52:2419-2423, 1992

151. T. Sato, H. Saito, J. Swensen, A. Olifant, C. Wood, D. Danner, T. Sakamoto, K. Takita, F. Kasumi, Y. Miki, M. Skolnick, Y. Nakamura: The human prohibitin gene, located on chromosome 17q21 is mutated in sporadic breast cancer. Cancer Research, 52:1643-1646, 1992

152. M.H. Jones, and Y. Nakamura: Deletion mapping of chromosome 3p in female genital tract malignancies using microsatellite polymorphisms. Oncogene, 7:1631-1634, 1992

153. E. Tsuchiya, Y. Nakamura, S. Weng, K. Nakagawa, S. Tsuchiya, H. Sugano and T. Kitagawa: Allelotype of non-small cell lung carcinoma-comparison of loss of heterozygosity between squamous cell carcinoma and adenocarcinoma. Cancer Research, 52:2478-2481, 1992

154. M.H. Jones, K. Yamakawa and Y. Nakamura: Isolation and characterization of 19 dinucleotide-repeat polymorphisms on chromosome 3p. Human Molecular Genetics, 1:131-134, 1992

155. J. Utsunomiya, K. Tamura, R. Yoshikawa, Y. Miki, M. Miyaki, and Y. Nakamura: New insights into familial adenomatous polyposis. Recent Progress in Colorectal Cancer: Biology and Management of High Risk Groups., :203-210, 1992

156. E. Takahashi, K. Yamakawa, Y. Nakamura and T. Hori: A high resolution cytogenetic map of human chromosome 3: localization of 291 new cosmid markers by direct r-banding fluorescence in situ hybridization. Genomics, 13:1047-1055, 1992

157. D. Cherif, H. Der-Sarkissian, J. Derre, T. Tokino, Y. Nakamura and R. Berger: The 11q23 breakpoint in acute leukemia with t(11;19)(q23;p13) is distal to those of t(4;11),t(6;11) and t(9;11). Genes Chromosomes and Cancer, 4:107-112, 1992

158. K. Takita, T. Sato, M. Miyagi, M. Watatani, F. Akiyama, G. Sakamoto, F. Kasumi, R. Abe, and Y. Nakamura: Correlation of loss of alleles on the short arms of chromosome 11 and 17 with metastasis of primary breast cancer to lymphnodes. Cancer Research, 52:3914-3917, 1992

159. M. Jones, and Y. Nakamura: Somatic mutations at CA-repeat loci. Human Mutation, 1:224-228, 1992

160. H. Nagase, Y. Miyoshi, A. Horii, T. Aoki, M. Ogawa, J. Utsunomiya, S. Baba, T. Sasazuki and Y. Nakamura: Correlation between the location of germ-line mutations in the APC gene and the

number of colorectal polyps in familial adenomatous polyposis (FAP) patients. Cancer Research, 52:4055-4057, 1992

161. A. Horii, S. Nakatsuru, Y. Miyoshi, S. Ichii, H. Nagase, Y. Kato, A. Yanagisawa and Y. Nakamura: The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer. Cancer Research, 52:3231-3233, 1992

162. K. Takita, A. Tanigami, T. Tokino, C. Jones and Y. Nakamura: Identification of 57 conventional RFLP and 6 VNTR systems with 32 DNA clones on chromosome 11p15. Genomics, 13:1296-1299, 1992

163. M. Peter, J. Michon, P. Vielh, S. Neuenschwander, Y. Nakamura, E. Sonsino, J.-M. Zucker, G. Vergnaud, G. Thomas and O. Delattre: PCR assay for chromosome 1p deletion in small neuroblastoma samples. International Journal of Cancer, 52:544-548, 1992

164. M. Emi, K. Koyama, K. Okui, E. Takahashi, M. Oshimura and Y. Nakamura: Isolation and mapping of 88 new RFLP markers on human chromosome 8. Genomics, 13:1261-1266, 1992

165. Y. Miyoshi, H. Nagase, H. Ando, A. Horii, S. Ichii, S. Nakatsuru, T. Aoki, Y. Miki, T. Mori and Y. Nakamura: Somatic mutation of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Human Molecular Genetics, 1:229-233, 1992

166. K. Yamakawa, E. Takahashi, M. Murata, K. Okui, S. Yokoyama and Y. Nakamura: Detailed mapping around the breakpoint of (3;8) translocation in familial renal cell carcinoma and FRA3B. Genomics, 14:412-416, 1992

167. K. Tsukamoto, T. Tohma, T. Ohta, K. Yamakawa, Y. Fukushima, Y. Nakamura and N. Niikawa: Cloning and characterization of the inversion breakpoint at chromosome 2q35 in a patient with Waardenburg syndrome type I. Human Molecular Genetics, 1:315-317, 1992

168. M. Emi, Y. Fujiwara, T. Nakajima, E. Tsuchiya, H. Tsuda, S. Hirohashi, M. Miyaki and Y. Nakamura: Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer. Cancer Research, 52:5368-5372, 1992

169. C. Larsson, J. Shepherd, Y. Nakamura, C. Blomberg, G. Weber, B. Werelius, N. Hayward, B. Teh, T. Tokino, B. Seizinger, B. Skogseid, K. Oberg, and M. Nordenskjold: Predictive testing for multiple endocrine neoplasia type 1 using DNA polymorphisms. Journal of Clinical Investigation, 89:1344-1349, 1992

170. W. Cookson, R.P. Young, A.J. Sandford, M.F. Moffatt, T. Shirakawa, P.A. Sharp, J.A. Faux, C. Julier, R.A. Wells, P.N. Le Souef, Y. Nakamura, G.M. Lathrop and J.M. Hopkin: Maternal inheritance of atopic IgE responsiveness on chromosome 11q. Lancet, 340:381-384, 1992

171. S. Ichii, A. Horii, S. Nakatsuru, J. Furuyama, J. Utsunomiya and Y. Nakamura: Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP). Human Molecular Genetics, 1:387-390, 1992

172. Y. Nakamura, I. Nishisho, K. Kinzler, B. Vogelstein, Y. Miyoshi, Y. Miki, H. Ando, A. Horii, and H. Nagase: Mutations of the adenomatous polyposis coli gene in familial polyposis coli patients and sporadic colorectal tumors. Multistage carcinogenesis, :285-292, 1992

173. S. Saito, H. Saito, S. Koi, S. Sagae, R. Kudo, J. Saito, K. Noda and Y. Nakamura: Fine-scale deletion mapping of the distal long arm of chromosome 6 in 70 human ovarian cancers. Cancer Research, 52:5815-5817, 1992

174. NIH, CEPH Collaborative Mapping Group: A comprehensive genetic linkage map of the human genome. Science, 258:67-86, 1992

175. A. Horii, S. Nakatsuru, Y. Miyoshi, S. Ichii, H. Nagase, H. Ando, A. Yanagisawa, E. Tsuchiya, Y. Kato, and Y. Nakamura: Frequent Somatic mutation of the APC gene in human pancreatic cancer. Cancer Research, 52:6696-6698, 1992

176. M. Shohat, X. Bu, T. Shohat, N. Fischel-Ghodsian, N. Magal, Y. Nakamura, A.D. Schwabe, M. Schlezinger, Y. Danon, J.I. Rotter: The gene for familial mediterranean fever in both Armenians and non-ashkenazi Jews is linked to the alpha-globin complex on 16p: evidence for locus homogeneity. Am. J. Human Genetics, 51:1349-1354, 1992

177. M. Miyagi, J. Inazawa, K. Takita, and Y. Nakamura: Cloning and characterization of the breakpoint of an interstitial deletion at chromosome 11p15 in a sporadic breast cancer. Human Molecular Genetics, 1:705-708, 1992

178. S. Nakatsuru, A. Yanagisawa, S. Ichii, E. Tahara, Y. Kato, Y. Nakamura, and A. Horii: Somatic mutation of the APC gene in gastric cancer: Frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma. Human Molecular Genetics, 1:559-563, 1992

179. S. Nagafuchi, Y. Nakahori, Y. Nakamura, S.B. England, T. Tamura, H. Numabe, and Y. Nakagome: Localization of 24 cosmid clones on the human Y chromosome. Japanese Journal of Human Genetics, 37:307-310, 1992

180. H. Nagase, Y. Miyoshi, A. Horii, T. Aoki, G.M. Petersen, B. Vogelstein, E. Maher, M. Ogawa, J. Utsunomiya, S. Baba, and Y. Nakamura: Screening for Germ-Line Mutations in Familial Adenomatous Polyposis (FAP) Patients: 61 new patients and a summary of 150 Unrelated Patients. Human Mutation, 1:467-473, 1992

181. Y. Nakamura, I. Nishisho, K.W. Kinzler, B. Vogelstein, Y. Miyoshi, Y. Miki, H. Ando, and A. Horii: Mutations of the APC (Adenomatous Polyposis Coli) gene in FAP (Familial Polyposis Coli) patients and in sporadic colorectal tumors. Tohoku J. Exp. med., 168:141-147, 1992

182. S. Olschwang, R. Fabre, P. Laurentpuig, A. Vassal, B. Hamelin, Y. Nakamura, and G. Thomas: Detection by dgge of a new polymorphism closely linked to the adenomatous polyposis-coli region. Human Genetics, 88:658-660, 1992

183. S. Saito and Y. Nakamura: A genetic linkage map with 16 RFLP loci on the distal long arm of human chromosome 6. Genomics, 15:103-106, 1993

184. K. Yamakawa, Ta. Takahashi, Y. Horio, Y. Murata, E. Takahashi, K. Hibi, S. Yokoyama, R. Ueda, To. Takahashi and Y. Nakamura: Frequent homozygous deletion in lung cancer cell lines detected by a DNA marker located at 3p21.3-p22. Oncogene, 8:327-330, 1993

185. E. Arai, T. Tokino, T. Imai, J. Inazawa, Y. Ikeuchi, A. Tonomura, and Y. Nakamura: Mapping the breakpoint of a constitutional translocation on chromosome 22 in a patient with NF2. Genes Chromosomes and Cancer, 6:235-238, 1993

186. W. Neuman, C. Westbrook, M. Dixon, R. Espinosa, Y. Patel, Y. Nakamura, B. Weiffenbach, and M. LeBeau: Physical localization of 70 polymorphic markers to human chromosome 5 by fluorescence in situ hybridization. Cytogenetics Cell Genetics, 62:207-210, 1993

187. Y. Fujiwara, M. Monden, T. Mori, Y. Nakamura, and Mitsuru Emi: Frequent multiplication of the long arm of chromosome 8 in hepatocellular carcinoma. Cancer Research, 53:857-860, 1993

188. H. Ando, Y. Miyoshi, H. Nagase, S. Baba, and Y. Nakamura: Detection of twelve germ-line mutations in the adenomatous polyposis coli (APC) gene by PCR. Gastroenterology, 104:989-993, 1993

189. G.M. Petersen, C. Francomano, K. Kinzler, Y. Nakamura: Presymptomatic direct detection of adenomatous polyposis coli (APC) gene mutations in familial adenomatous polyposis. Human Genetics, 91:307-311, 1993

190. M. Emi, Y. Fujiwara, and Y. Nakamura: A primary genetic linkage map of 14 polymorphic loci for the short arm of human chromosome 8. Genomics, 15:530-534, 1993

191. A. Horii, S. Nakatsuru, S. Ichii, H. Nagase, and Y. Nakamura: Multiple forms of the APC gene transcripts and their tissue-specific expression. Human Molecular Genetics, 2:283-287, 1993

192. K. Koyama, M. Emi, and Y. Nakamura: The Cell Adhesion Regulator (CAR) gene: TaqI and insertion/deletion polymorphisms, and regional assignment to periteromeric region of 16q by linkage analysis. Genomics, 16:264-265, 1993

193. S. Takeda, S. Ichii and Y. Nakamura: Detection of K-ras mutation in sputum by mutant-allele-specific amplification (MASA). Human Mutation, 2:112-117, 1993

194. H. Ohata, M. Emi, Y. Fujiwara, K. Higashino, K. Nakagawa, R. Futagami, E. Tsuchiya, and Y. Nakamura: Deletion mapping of the short arm of chromosome 8 in non-small cell lung carcinoma. Genes Chromosomes and Cancer, 7:85-88, 1993

195. Y. Nakamura:, The role of the adenomatous polyposis coli (APC) gene in human cancers (review article). Advance in Cancer Genetics, 62:65-87, 1993

196. S. Takiguchi, S. Saito and Y. Nakamura: Characterization of four VNTR loci on human chromosome 6. Mammalian Genome, 4:21-24, 1993

197. Y. Fujiwara, M. Emi, H. Ohata, Y. Kato, T. Nakajima, T. Mori, and Y. Nakamura: Evidence for a presence of two tumor suppressor genes on chromosome 8p for colorectal carcinoma. Cancer Research, 53:1172-1174, 1993

198. J. Melki, P. Burlet, O. Clermont, F. Pascal, B. Paul, S. Abdelhak, R. Sherrington, H. Gurling, Y. Nakamura, J. Weissenbach, M. Lathrop and A. Munnich: Refined linkage map of chromosome 5 in the region of spinal muscular atrophy gene. Genomics, 15:521-524, 1993

199. J. Inazawa, H. Saito, T. Ariyama, T. Abe, and Y. Nakamura: High-resolution cytogenetic mapping of 342 new cosmid markers including 43 RFLP markers on human chromosome 17 by fluorescence in situ hybridization. Genomics, 17:153-162, 1993

200. Y. Horio, Ta. Takahashi, T. Kuroishi, K. Hibi, M. Suyama, T. Niimi, K. Shimokata, K. Yamakawa, Y. Nakamura, R. Ueda, and To. Takahashi: Prognostic significance of p53 mutation and 3p deletion in primary resected non-small cell lung cancer. Cancer Research, 53:1-4, 1993

201. A.J. Sandford, T. Shirakawa, M.F. Moffatt, S.E. Daniels, C. Ra, J.A. Faux, R.P. Young, Y. Nakamura, G.M. Lathrop, W. Cookson and J.M. Hopkin: Localization of atopy and the βsubunit of high-affinity IgE receptor (FcERI) on chromosome 11q. Lancet, 341:332-334, 1993

202. M. Emi, Y. Fujiwara, H. Ohata, H. Tsuda, S. Hirohashi, M. Koike, M. Miyaki, M. Monden, and Y. Nakamura: Deletion of chromosome 8p21.3-p22 is associated with progression of hepatocellular carcinoma. Genes Chromosomes and Cancer, 7:152-157, 1993

203. P.A. Crossey, E.R. Maher, M.H. Jones, F.M. Richards, F. Latif, M.E. Pipps, M. Lush, K. Foster, K. Tory, J.S. Green, B. Oostra, J.R.W. Yates, W.M. Linehan, N.A. Affara, M. Lerman, B. Zbar, Y. Nakamura, and M.A. Ferguson-Smith: Genetic linkage between Von Hippel-Lindau disease and three microsatellite polymorphisms refines the localization of the VHL locus. Human Molecular Genetics, 2:279-282, 1993

204. S. Takiguchi, T. Tokino, T. Imai, A. Tanigami, K. Koyama, and Y. Nakamura: Identification and characterization of a cDNA, which is highly homologous to the ribonucleoprotein gene, from a locus (D10S102) closely linked to MEN2 (multiple endocrine neoplasia type 2). Cytogenetics Cell Genetics, 64:128-130, 1993

205. T. Mori, H. Nagase, T. Aoki, H. Arakawa, T. Nishihira, S. Mori, and Y. Nakamura: The APC

(adenomatous polyposis coli) gene: a novel mutation in an FAP patient and a DdeI polymorphism in the 5' non-coding region. Human Mutation, 2:240-243, 1993

206. S. Mole, M. Jackson, T. Tokino, Y. Nakamura, and B. Ponder: Assignment of fifty-four cosmid clones to five regions of chromosome 10. Genomics, 15:457-458, 1993

207. S. Ichii, H. Nagase, T. Mori, S. Baba, and Y. Nakamura: A novel mutation of the APC (adenomatous polyposis coli) gene in a familial adenomatous polyposis (FAP) patient and presymptomatic diagnosis using PCR. Human Molecular Genetics, 2:597, 1993

208. T. Miwa, K. Sudo, Y. Nakamura, and T. Imai: Fifty sequenced-tagged sites on human chromosome 11. Genomics, 17:211-214, 1993

209. T. Sato, T. Sakamoto, K. Takita, H. Saito, K. Okui, and Y. Nakamura: The human prohibitin (PHB) gene family and its somatic mutation in human tumors. Genomics, 17:762-764, 1993

210. S. Ichii, S. Takeda, A. Horii, S. Nakatsuru, Y. Miyoshi, M. Emi, Y. Fujiwara, K. Koyama, J. Furuyama, J. Utsunomiya, and Y. Nakamura: Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP). Oncogene, 8:2399-2405, 1993

211. M. Koi, L.A. Johnson, L.M. Kalikin, P.F.R. Little, Y. Nakamura, and A. Feinberg: Tumor cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11. Science, 260:361-364, 1993

212. E. Takahashi, S. Hitomi, K. Koyama, and Y. Nakamura: A high-resolution cytogenetic map of human chromosome 5: localization of 206 new cosmid markers by direct R-banding fluorescence in situ hybridization. Genomics, 17:234-236, 1993

213. H. Saito, J. Inazawa, S. Saito, F. Kasumi, S. Koi, S. Sagae, R. Kudo, J. Saito, K. Noda, and Y. Nakamura: Detailed Deletion Mapping of Chromosome 17q in Ovarian and Breast Cancers: 2-cM Region on 17q21.3 Often and Commonly Deleted in Tumors. Cancer Research, 53:3382-3385, 1993

214. E. Takahashi, K. Koyama, S. Hitomi, and Y. Nakamura: A high-resolution cytogenetic map of human chromosome 12: localization of 195 new cosmid markers by direct R-banding fluorescence in situ hybridization. Human Genetics, 92:405-409, 1993

215. H. Han, A. Yanagisawa, Y. Kato, J. Park, and Y. Nakamura: Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Research, 53:5087-5089, 1993

216. H. Nagase and Y. Nakamura: Mutations of the APC (adenomatous polyposis coli) gene. Human Mutation, 2:425-434, 1993

217. T. Tokino, N. Davidson, K. Helzlsour, B. Zehnhauer, Y. Nakamura, B. Vogelstein, and D. Sidransky: Absence of germline prohibitin mutations in early onset breast cancer. International Journal of Oncology, 3:769-772, 1993

218. S. Nakatsuru, A. Yanagisawa, Y. Furukawa, S. Ichii, Y. Kato, Y. Nakamura, and A. Horii: Somatic mutations of the APC gene in precancerous lesion of the stomach. Human Molecular Genetics, 2:1463-1465, 1993

219. M. Konishi, R. Kikuchi-Yanoshita, K. Tanaka, C. Sato, K. Tsuruta, Y. Maeda, M. Koike, S. Tanaka, Y. Nakamura, N. Hattori, and M. Miyaki: Genetic changes and histopathological grades in human hepatocellular carcinomas. Japanese Journal of Cancer Research, 84:893-899, 1993

220. M. Emi, T. Katagiri, Y. Harada, H. Saito, J. Inazawa, I. Ito, F. Kasumi, and Y. Nakamura: A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers. Nature Genetics, 5:151-157, 1993

221. W. Liu, M. Piechocki, V. Shridhar, G. Lyles, Z. Song, Y. Nakamura, H. Drabkin, J. Vance, and D.I. Smith: The isolation of a yeast artificial chromosome (YAC) contig extending for 2 megabases in the vicinity of the Von Hippel Lindau disease gene. Human Molecular Genetics, 2:1177-1182, 1993

222. H.-J. Han, T. Fujiwara, S. Shin, and Y. Nakamura: Dinucleotide repeat polymorphisms in the 3' non-coding region of the FLT1 gene. Human Molecular Genetics, 2:2204, 1993

223. T. Toda, M. Segawa, Y. Nomura, I. Nonaka, K. Masuda, T. Ishihara, M. Suzuki, I. Tomita, Y. Origuchi, K. Ohno, N. Misugi, Y. Sasaki, K. Takada, M. Kawai , K. Ohtani, T. Murkami, K. Saito, Y. Fukuyama, T. Shimizu, I. Kanazawa, and Y. Nakamura: Localization of a gene for Fukuyama type congenital muscular dystrophy (FCMD) to chromosome 9q31-33. Nature Genetics, 5:283-286, 1993

224. R.J. Sinke, A. Tanigami, Y. Nakamura, and A. Geurts van Kessel: Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13. Genomics, 18:165, 1993

225. T. Tohma, T. Tamura, T. Ohta, H. Soejima, T. Kubota, Y. Jinno, K. Tsukamoto, Y. Nakamura, K. Naritomi, and N. Niikakwa: Cosmid clones from microdissected human chromosomal region 15q11-q13. Japanese Journal of Human Genetics, 38:267-275, 1993

226. M.E. Phipps, E.R. Maher, N.A. Affara, F. Latif, M.A. Leversha, M.E. Fergusonsmith, Y. Nakamura, M. Lerman, B. Zbar, and M.A. Fergusonsmith: Physical mapping of chromosome 3p25-p26 by fluorescence in-situ hybridization (fish). Human Genetics, 92:18-22, 1993

227. W. Bruening, P. Gros, T. Sato, J. Stanimir, Y. Nakamura, D. Housman, and J. Pelletier Analysis of the 11p13 Wilms' Tumor Suppressor Gene (WTI) in Ovarian Tumors Cancer Investigation,

4:393-399, 1993 228. E.R. Maher, D.E. Barton, R . Slatter, D.J. Koch, M.H. Jones, H. Nagase, S. Payne, S.J. Charles,

A.T. Moore, Y. Nakamura, and M.A. Ferguson-Smith: Evaluation of molecular genetic diagnosis in the management of familial adenomatous polyposis coli: a population based study. Journal of Medical Genetics, 30:675-678, 1993

229. A. Kurimasa, Y. Nagata, M. Emi, Y. Nakamura, and M. Oshimura: A human gene that restores the DNA-repair defect in SCID mice is located on 8p11.1-q11.1. Human Genetics, 93:21-26, 1994

230. K. Yoshiura, J. Inazawa, K. Koyama, Y. Nakamura, and N. Niikawa: Mapping of the 8q translocation breakpoint of t(8;13) observed in a patient with multiple exostoses. Genes Chromosomes and Cancer, 9:57-61, 1994

231. Y. Nakamura, K. Okui, E. Takahashi, and K. Koyama: Isolation and mapping of 328 new cosmid markers on human chromosome 8: construction of a high resolution cytogenetic map of chromosome 8 with 416 markers. Cytogenetics Cell Genetics, 65:115-118, 1994

232. Y. Furukawa, S. Nakatsuru, A. Nagafuchi, S. Tsukita, T. Muto, Y. Nakamura, and A. Horii: Structure, expression and chromosome assignment of the human catenin(cadherin-associated protein) alpha 1 gene(CTNNA1). Cytogenetics Cell Genetics, 65:74-78, 1994

233. J. Inazawa, T. Ariyama, T. Tokino, A. Tanigami, Y. Nakamura, and T. Abe: High-resolution ordering of DNA markers by multi-color fluorescent in situ hybridization of prophase chromosomes. Cytogenetics Cell Genetics, 65:130-135, 1994

234. M. Isomura, A. Tanigami, H. Saito, Y. Harada, T. Katagiri, J. Inazawa, D.H. Ledbetter, and Y. Nakamura: Detailed analysis of loss of heterozygosity on chromosome band 17p13 in breast carcinoma on the basis of a high-resolution physical map with 29 markers. Genes Chromosomes and Cancer, 9:173-179, 1994

235. T. Mori, H. Nagase, A. Horii, Y. Miyoshi, S. Nakatsuru, T. Aoki, H. Arakawa, A. Yanagisawa, Y. Ushio, S. Takano, M. Ogawa, M. Nakamura, M. Shibuya, R. Nishikawa, M. Matsutani, Y. Hayashi, H. Takahashi, F. Ikuta, T. Nishihira, S. Mori, and Y. Nakamura: Germ-line and somatic mutations of the APC gene in patients with Turcot syndrome and analysis of APC mutations in brain tumors. Genes Chromosomes and Cancer, 9:168-172, 1994

236. K. Tsukamoto, Y. Nakamura, and N. Niikawa: Isolation of two isoforms of the PAX3 gene transcripts and their tissue-specific alternative expression in human adult tissues. Human Genetics, 93:270-274, 1994

237. R.J. Sinke, D. Olde Weghuis, R.F. Suijkerbuijk, A. Tanigami, Y. Nakamura, C. Larsson, G. Weber, B. de Jong, J.W. Oosterhuis, W.A. Molenaar, and A. Geurts van Kessel: Molecular characterization of a recurring complex chromosomal translocation in two human extragonadal germ cell tumors. Cancer Genetics Cytogenetics, 73:11-16, 1994

238. Y. Fujiwara, H. Ohata, M. Emi, K. Okui, K. Koyama, E. Tsuchiya, M. Monden, T. Mori, A. Kurimasa, M. Oshimura, and Y. Nakamura: A 3-Mb physical map of the chromosome region 8p21.3-p22, including a 600-kb region commonly deleted in human hepatocellular carcinoma, colorectal cancer, and non-small cell lung cancer. Genes Chromosomes and Cancer, 10:7-14, 1994

239. M.H. Jones, S. Koi, I. Fujimoto, K. Hasumi, K. Kato, and Y. Nakamura: Allelotype of Uterine cancer by analysis of RFLP and microsatellite polymorphisms: Frequent loss of heterozygosity on chromosomes arms 3p, 9q, 10q, and 17p. Genes Chromosomes and Cancer, 9:119-123, 1994

240. T. Aoki, S. Takeda, A. Yanagisawa, Y. Kato, Y. Ajioka, H. Watanabe, S. Kudo, and Y. Nakamura: APC and p53 mutations in de novo colorectal adenocarcinomas. Human Mutation, 3:342-346, 1994

241. O. Takeda, C. Homma, N. Maseki, M. Sakura, N. Kanda, M. Schwab, Y. Nakamura, and Y. Kaneko: There may be two tumor suppressor genes on chromosome arm 1p closely associated with biologically distinct subtypes of neuroblastoma. Genes Chromosomes and Cancer, 10:30-39, 1994

242. T. Aoki, T. Mori, D. XiQun, T. Nishihira, T. Matsubara, and Y. Nakamura: Allelotype study of esophageal carcinoma. Genes Chromosomes and Cancer, 10:177-182, 1994

243. T. Toda, A. Iida, T. Miwa, Y. Nakamura, and T. Imai: Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1). Human Molecular Genetics, 3:465-470, 1994

244. H. Tsuda, D.F. Callen, T. Fukutomi, Y. Nakamura, and S. Hirohashi: Allele loss on chromosome 16q24.2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extent of spread. Cancer Research, 54:513-517, 1994

245. H. Arakawa, N. Hayashi, H. Nagase, M. Ogawa, and Y. Nakamura: Alternative splicing of the NF2 gene and its mutation analysis of breast and colorectal cancers. Human Molecular Genetics, 3:565-568, 1994

246. T. Mori, T. Aoki, T. Matsubara, F. Iida, D. XiQun, T. Nishihira, S. Mori, and Y. Nakamura: Frequent loss of heterozygosity in the region including BRCA1 on chromosome 17q in squamous cell carcinomas of the esophagus. Cancer Research, 54:1638-1640, 1994

247. K. Koyama, K. Sudo, and Y. Nakamura: Mapping of the human nicotinic acetylcholine receptor β3 Gene (CHRNB3) within Chromosome 8p11.2. Genomics, 21:460-461, 1994

248. E. Arai, T. Ikeuchi, and Y. Nakamura: Characterization of the translocation breakpoint on chromosome 22q12.2 in a patient with neurofibromatosis type 2 (NF2). Human Molecular Genetics, 3:937-939, 1994

249. E. Takahashi, K. Koyama, A. Hitomi, H. Itoh, and Y. Nakamura: A high-resolution cytogenetic map of human chromosome 9: Localization of 203 new cosmid markers by direct R-banding fluorescence in situ hybridization. Genomics, 19:373-375, 1994

250. H. Arakawa, H. Nagase, N. Hayashi, T. Fujiwara, M. Ogawa, S. Shin, and Y. Nakamura: Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. Biochemical and Biophysical Research Communications, 200:836-843, 1994

251. N. Iwai, N. Ohmichi, K. Hanai, Y. Nakamura, and M. Kinoshita: Human SA gene locus as a candidate for essential hypertension. Hypertension, 23:375-380, 1994

252. M. Mannens, J.M.N. Hoovers, E. Redeker, M. Verjaal, A.P. Feinberg, P. Little, M. Boavida, N. Coad, M. Steenman, J. Bliek, N. Niikawa, H. Tonoki, Y. Nakamura, E.G. de Boer, R.M. Slater, R. John, J.K. Cowell, C. Junien, I. Henry, R. Weksberg, S.M. Pueshel, N.J. Leschot, A. Westerveld: Parental imprinting of human chromosome region 11p15.3-pter involved in the Beckwith-Wiedemann syndrome and various human neoplasia. Eur. J. Human Genetics, 2:3-23, 1994

253. N. Uhrhammer, P. Concannon, Y. Huo, Y. Nakamura, and R.A. Gatti: A pulsed-field gel electrophoresis map in the ataxia-telangiectasia region of chromosome 11q22.3. Genomics, 20:278-280, 1994

254. M. Nishiyama, J. Inazawa, T. Ariyama, Y. Nakamura, S. Matsufuji, A. Furusawa, T. Tanaka, S. Hayashi, and J.R. Wands: The human insulin receptor substrate-1 gene (IRS1) is localized on 2q36. Genomics, 20:139-141, 1994

255. N. Hayashi, H. Arakawa, H. Nagase, M. Ogawa, and Y. Nakamura: Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method. Cancer Research, 54:3853-3856, 1994

256. T. Tanaka, K. Nakahara, N. Kato, T. Imai, T. Yamazaki, R. Nagai, Y. Yazaki, and Y. Nakamura: Genetic linkage analyses of Romano-Ward syndrome (RWS) in 13 Japanese families. Human Genetics, 94:380-384, 1994

257. K. Hibi, K. Yamakawa, R. Ueda, Y. Horio, Y. Murata, M. Tamari, K. Uchida, T. Takahashi, Y. Nakamura, and T. Takahashi: Aberrant upregulation of a novel integrin α subunit gene at 3p21.3 in small cell lung cancer. Oncogene, 9:611-619, 1994

258. S. Hosoe, K. Ueno, Y. Shigedo, I. Tachibana, T. Osaki, T. Kumagai, Y. Tanio, I. Kawase, Y. Nakamura, and T. Kishimoto: A frequent deletion of chromosome 5q21 in advanced small cell and non-small cell carcinoma of the lung. Cancer Research, 54:1787-1790, 1994

259. Y. Harada, T. Katagiri, I. Itoh, F. Akiyama, G. Sakamoto, F. Kasumi, Y. Nakamura, and M. Emi: Genetic studies of 457 breast cancers; clinicopathological parameters compared with genetic alterations. Cancer, 74:2281-2286, 1994

260. Y. Murata, M. Tamari, T. Takahashi, Y. Horio, K. Hibi, S. Yokoyama, J. Inazawa, K. Yamakawa, A. Ogawa, T. Takahashi and Y. Nakamura: Characterization of an 800 kb region at 3p22-p21.3 that was homozygously deleted in a lung cancer cell line. Human Molecular Genetics, 3:1341-1344, 1994

261. T. Ichikawa, N. Nihei, H. Suzuki, M. Oshimura, M. Emi, Y. Nakamura, I. Hayata, J.T. Isaacs, and J. Shimazaki: Suppression of metastasis of rat prostatic cancer by introducing human chromosome 8. Cancer Research, 54:2299-2302, 1994

262. A. Horii, H.-J. Han, M. Shimada, A. Yanagisawa, Y. Kato, H. Ohta, W. Yasui, E. Tahara, and Y. Nakamura: Frequent replication errors at microsatellite loci in tumors of patients with multiple primary cancers. Cancer Research, 54:3373-3375, 1994

263. T. Mori, K. Miura, T. Aoki, T. Nishihira, S. Mori, and Y. Nakamura: Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma. Cancer Research, 54:3396-3397, 1994

264. S. Nakatsuru, K. Sudo, and Y. Nakamura: Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications, 202:82-87, 1994

265. S. Hosoe, Y. Shigedo, K. Ueno, I. Tachibana, T. Osaki, Y. Tanio, I. Kawase K. Yamakawa, Y. Nakamura, and T. Kishimoto: Detailed deletion mapping of the short arm of chromosome 3 in small cell and non-small cell carcinoma of the lung. Lung Cancer, 10:297-305, 1994

266. T. Toda, S. Ikegawa, K. Okui, E. Kondo, K. Saito, Y. Fukuyama, I. Kanazawa, and Y. Nakamura: Refined mapping of a gene responsible for Fukuyama-type congenital muscular dystrophy; evidence for a strong linkage disequilibrium. Am. J. Human Genetics, 55:946-950, 1994

267. N. Hayashi, Y. Sugimoto, E. Tsuchiya, M. Ogawa, and Y. Nakamura: Somatic mutations of the MTS (multiple tumor suppressor) 1/ CDK4I (cyclin-dependent kinase-4inhibitor) gene in human primary non-small cell lung carcinomas. Biochemical and Biophysical Research Communications, 202:1426-1430, 1994

268. T. Tanaka, K. Okui, and Y. Nakamura: Assignment of the human caltractin gene (CALT) to Xq28

by fluorescence in situ hybridization. Genomics, 24:609-610, 1994 269. C.A. Westbrook, M.M. Le Beau, W.L. Neuman, M. Keinanen, L.H. Yamaoka, M.C. Speer, R.

EspinosaIII, Y. Nakamura, R. Williamson, M. Mullan, and K. Buetow: Physical and genetic map of 5q31: use of fluorescence in situ hybridization data to identify errors in the CEPH database. Cytogenetics Cell Genetics, 67:86-93, 1994

270. K. Sudo, K. Chinen, and Y. Nakamura: 2,058 expressed sequence tags (ESTs) from a human fetal lung cDNA library. Genomics, 24:276-279, 1994

271. T. Mori, A. Yanagisawa, Y. Kato, K. Miura, T. Nishihira, S. Mori, and Y. Nakamura: Accumulation of genetic alterations during esophageal carcinogenesis. Human Molecular Genetics, 3:1969-1971, 1994

272. M.H. Jones, T. Sato, H. Saito, A. Tanigami, and Y. Nakamura: Six microsatellite polymorphisms at candidate and confirmed tumour suppressor gene loci. Human Molecular Genetics, 3:1911, 1994

273. T. Sakamoto, N. Okamoto, Y. Ikeda, Y. Nakamura, and T. Sato: Dinucleotide-repeat polymorphism in DNA of rainbow trout and its application in fisheries science. J. Fish Biol., 44:1093-1096, 1994

274. J.-G. Park, H.-J. Han, M.-S. Kang, and Y. Nakamura: Presymptomatic diagnosis of familial adenomatous polyposis coli. Diseases of Colon and Rectum, 37:700-707, 1994

275. H. Ohata, Y. Fujiwara, K. Koyama, and Y. Nakamura: Mapping of the human autoantigen pericentriol material 1 (PCM1) gene to chromosome 8p21.3-p22. Genomics, 94:404-405, 1994

276. M.R. James, C.W. Richard, J. Schott, C. Yousry, K. Clark, J. Bell, J.D. Terwilliger, J. Hazan, C. Dubay, A. Vignal, M. Agrapart, T. Imai, Y. Nakamura, M. Polymeropoulos, J. Weissenbach, D.R. Cox, and G.M. Lathrop: A radiation hybrid map of 506 STS markers spanning human chromosome 11. Nature Genetics, 8:70-76, 1994

277. S. Sato, Y. Nakamura, and E. Tsuchiya: Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung. Cancer Research, 54:5652-5655, 1994

278. A. Horii, H.-J. Han, S. Sasaki, M. Shimada and Y. Nakamura: Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genes. Biochemical and Biophysical Research Communications, 204:1257-1264, 1994

279. M.J. Higgins, N.J. Smilinich, S. Sait, A. Koenig, J. Pongratz, M. Gessler, C.W. Richard, M.R. James, J.P. Sanford, B.-W. Kim, J. Cattelane, N.J. Nowak, C. Jones, Y. Nakamura, D.S. Gerhard, and T.B. Shows: An ordered NotI fragment map of human chromosome band 11p15. Genomics, 23:211-222, 1994

280. S. Baba, H. Ando, Y. Nakamura: Identification of germ line mutation of APC gene in possible carriers of familial adenomatous polyposis (FAP). Anticancer Res., 14:2189-2192, 1994

281. P.J. Eubanks, M.P. Sawicki, G.J. Samara, R. Gatti, Y. Nakamura, D. Tsao, C. Johnson, M. Hurwitz, Y.-J.Y. Wan, E. Passaro Jr: Putative tumor-suppressor gene on chromosome 11 is important in sporadic endocrine tumor formation The American Journal of Surgery, 167:180-185, 1994

282. E. Takahashi, K. Koyama, M. Hirai, H. Itoh, and Y. Nakamura: A high-resolution cytogenetic map of human chromosome 2: Localization of 434 cosmid markers by direct R-banding fluorescence in situ hybridization. Cytogenetics Cell Genetics, 68:112-114, 1995

283. S. Nakatsuru, K. Sudo, and Y. Nakamura: Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication. Cytogenetics Cell Genetics, 68:226-230, 1995

284. Y. Fujiwara, H. Ohata, T. Kuroki, K. Koyama, E. Tsuchiya, M. Monden, and Y. Nakamura: Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene. Oncogene, 10:891-895, 1995

285. T. Katagiri, Y. Harada, M. Emi and Y. Nakamura: Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing. Cytogenetics Cell Genetics, 68:39-44, 1995

286. H. Arakawa, H. Nagase, N. Hayashi, M. Ogawa, M. Nagata, T. Fujiwara, E. Takahashi, S. Shin and Y. Nakamura: Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA. Cytogenetics Cell Genetics, 70:235-238, 1995

287. T. Ariyama, J. Inazawa, T. Ezaki, Y. Nakamura, A. Horii, and T. Abe: High-resolution cytogenetic mapping of the short arm of chromosome 1 with newly isolated 411 cosmid markers by fluorescence in situ hybridization: The precise order of 18 markers on 1p36.1 on prophase chromosomes and "stretched" DNAs. Genomics, 25:114-123, 1995

288. Y. Hasegawa, S. Takeda, S. Ichii, K. Koizumi, M. Maruyama, A. Fujii, H. Ohta, T. Nakajima, M. Okuda, S. Baba, and Y. Nakamura: Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA) . Oncogene, 10:1441-1445, 1995

289. I. Ito, M. Yoshimoto, T. Iwase, S. Watanabe, T. Katagiri, Y. Harada, F. Kasumi, S. Yasuda, T. Mitomi, M. Emi, and Y. Nakamura: Association of genetic alterations on chromosome 17 with loss

of hormone receptors in breast cancer. British Journal of Cancer, 71:438-441, 1995 290. K. Chinen, K. Sudo, E. Takahashi, and Y. Nakamura: Isolation and mapping of the human

beta-signal sequence receptor gene (SSR2). Cytogenetics Cell Genetics, 70:215-217, 1995 291. T. Kawakami, Y. Furukawa, K. Sudo, H. Sait, E. Takahashi, and Y. Nakamura: Isolation and

mapping of a human gene (PDCD2) that is highly homologous to PR8, a rat gene associated with programmed cell death. Cytogenetics Cell Genetics, 71:41-43, 1995

292. H.-J. Han, M. Maruyama, S. Baba, J.-G. Park, and Y. Nakamura: Genomic structure of human mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary non-polyposis colorectal cancer (HNPCC). Human Molecular Genetics, 4:237-242, 1995

293. T. Ariyama, T. Kimura, K. Yamakawa, Y. Nakamura, T. Abe, and J. Inazawa: Precise ordering of 26 cosmid markers on chromosome region 3p23 --> p21.3 by two-color FISH on human prophase chromosomes and stretched DNAs. Cytogenetics Cell Genetics, 70:129-133, 1995

294. T. Ariyama, J. Inazawa, Y. Uemura, N. Kakazu, T. Maekawa, F. Urase, K. Irimajiri, A. Horiuchi., Y. Nakamura, and T. Abe: Clonal origin of Philaderphia chromosome negative cells with trisomy 8 appearing during the course of α-interferon therapy for Ph positive chronic myolocytic leukemia. Cancer Genetics Cytogenetics, 81:20-23, 1995

295. M. Kai, H. Arakawa, Y. Sugimoto, Y. Murata, M. Ogawa, and Y. Nakamura: Infrequent somatic mutation of the MTS1 gene in primary bladder carcinomas. Japanese Journal of Cancer Research, 86:249-251, 1995

296. K. Koyama, K. Sudo, and Y. Nakamura: Isolation of 115 human chromosome 8-specific expressed-sequence tags by exon amplification. Genomics, 26:245-253, 1995

297. S. Ikegawa, K. Sudo, K. Okui, and Y. Nakamura: Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2). Cytogenetics Cell Genetics, 71:182-186, 1995

298. S. Ikegawa, Y. Fukushima, M. Isomura, F. Takada and Y. Nakamura: Mutations of the fibroblast growth factor receptor-3 gene in one familial and six sporadic cases of achondroplasia in Japanese patients. Human Genetics, 96:309-311, 1995

299. N.K. Spurr, S. Blanton, R. Bookstein, R. Clarke, R. Cottingham, S.Daiger, D. Drayna, P. Faber, S. Horrigan, K. Kas, C. Kirchgessner, S. Kumar, R.J. Leach, J-J. Luedecke, Y. Nakamura, M-J. Pebusque, S. Ranta, E. Sim, L.S. Sullivan, L. Takle, J. Vance, M. Wagner, D. Wells, C. Westbrook, L. Yaremko, D. Zaletayev, O. Zuffardi, and S. Wood: Report and abstracts of the second international workshop on human chromosome 8 mapping 1994. Cytogenetics Cell Genetics, 68:147-164, 1995

300. A. Iida, K. Blake, T. Tunny, S. Klemm, M. Stowasser, N. Hayward, R. Gordon, Y. Nakamura, and T. Imai: Allelic losses on chromosome band 11q13 in aldosterone-producing adrenal tumors. Genes Chromosomes and Cancer, 12:73-75, 1995

301. T. Kuroki, Y. Fujiwara, E. Tsuchiya, S. Nakamori, Y. Imaoka, T. Kanematsu, and Y. Nakamura: Accumulation of genetic changes during development and progression of hepatocellular carcinoma: LOH on chromosome arm 1p occurs at an early stage of hepatocarcinognesis. Genes Chromosomes and Cancer, 13:163-167, 1995

302. N. Hayashi, I. Ito, A. Yanagisawa, Y. Kato, S. Nakamori, S. Imaoka, H. Watanabe, M. Ogawa, and Y. Nakamura: Genetic diagnosis of lymph-node metastasis in colorectal cancer. Lancet, 345:1257-1259, 1995

303. N. Hashimoto, D. Ichikawa, Y. Arakawa, K. Date, S. Ueda, Y. Nakagawa, A. Horii, Y. Nakamura, T. Abe, and J. Inazawa: Frequent deletions of material from chromosome arm 1p in oligodendroglial tumors revealed by double-target fluorescence in situ hybridization and microsatellite analysis. Genes Chromosomes and Cancer, 14:295-300, 1995

304. K. Miura, K. Okita, Y. Furukawa, S. Matsuno, and Y. Nakamura: Deletion mapping in squamous cell carcinomas of the esophagus defines a region containing a tumor suppressor gene within a 4-cM interval of the distal long arm of chromosome 9. Cancer Research, 55:1828-1830, 1995

305. T. Toda, M. Yoshioka, Y. Nakahori, I. Kanazawa, Y. Nakamura, and Y. Nakagome: Genetic identity of Fukuyama-type congenital muscular dystrophy and Walker-Warburg syndrome. Ann. Neurol, 37:99-101, 1995

306. H. Soejima, K. Yoshiura, T. Tamura, T. Tokino, Y. Nakamura, Y. Niikawa, and Y. Jinno: Fifty novel sequences-tagged sites (STSs) on human chromosome 11q13.4-q25 identified from microclones generated by microdissection. Cytogenetics Cell Genetics, 70:108-111, 1995

307. S. Inoue, A. Orimo, Y. Matsuda, J. Inazawa, M. Emi, Y. Nakamura, T. Hori, and M. Muramatsu: Chromosomal mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family. Genomics, 25:581-583, 1995

308. T. Kuroki, Y. Fujiwara, S. Nakamori, Y. Imaoka, T. Kanematsu, and Y. Nakamura: Evidence for the presence of two tumor-suppressor genes for hepatocellular carcinoma on chromosome 13q. British Journal of Cancer, 72:383-385, 1995

309. M. Shimada, A. Horii, S. Sasaki, A. Yanagisawa, Y. Kato, K. Yamashita, K. Okagawa, K. Yamasaki, S. Ishiguro, M. Inoue, H. Shiozaki, and Y. Nakamura: Infrequent replication errors at microsatellite loci in tumors of patients with multiple primary cancers of the esophagus and various other tissues. Japanese Journal of Cancer Research, 86:511-515, 1995

310. K. Sudo, E. Takahashi, and Y. Nakamura: Isolation and mapping of human EIF4A2 gene

homologous to the murine protein synthesis initiation factor 4A-II gene eIF4A-II. Cytogenetics Cell Genetics, 71:385-388, 1995

311. K. Kobayashi, S. Sagae, R. Kudo, H. Saito, S. Koi, and Y. Nakamura: Microsatellite instability in endometrial carcinomas; frequent replication errors in tumors of early onset and/or of poorly differentiated type. Genes Chromosomes and Cancer, 14:128-132, 1995

312. M. Matsushima, K. Kobayashi, M. Emi, H. Saito, J. Saito, K. Suzumori, Y. Nakamura: Mutations analysis of the BRCA1 gene in 76 Japanese ovarian cancer patients; four germline mutations, but no evidence of somatic mutation. Human Molecular Genetics, 4:1953-1956, 1995

313. H. Suzuki, M. Emi, A. Komiya, Y. Fujiwara, R. Yatani, Y. Nakamura, and J. Shimazaki: Localization of a tumor suppressor gene associated with progression of human prostate cancer within a 1.2 Mb region of 8p22-p21.3. Genes Chromosomes and Cancer, 13:168-174, 1995

314. T. Watanabe, T.Fujiwara, H. Shinomiya, Y. Kuga, H. Hishigaki, Y.Nakamura, and Y.Hirai: Molecular cloning of a novel human cDNA, RT14, containing a putative ORF highly conserved between human, fruit fly, and nematode. DNA Research, 2:235-237, 1995

315. T. Toda, S. Ikegawa, M. Miyake, Y. Nakahori, and Y. Nakamura: Dinucleotide repeat polymorphism on chromosome 9q32. Japanese Journal of Human Genetics, 40:333-334, 1995

316. Y. Nakamura: The APC (Adenomatous Polyposis Coli) gene and human cancers. JCRCO, 121:529-534, 1995

317. T. Fujiwara, A. Kawai, F. Shimizu, H. Hirano, S. Okuno, S. Takeda, K. Ozaki, Y. Shimada, M. Nagata, T. Watanabe, A. Takaichi, E. Takahashi, Y. Nakamura, and S. Shin: Cloning, sequencing and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit). DNA Research, 2:107-111, 1995

318. S. Takiguchi-Shirahama, K. Koyama, A. Miyauchi, T. Wakasugi, S. Oishi, H. Takami, K. Hikiji, and Y. Nakamura: Germline mutations of the RET proto-oncogene in eight Japanese patients with multiple endocrine neoplasia type 2A (MEN2A). Human Genetics, 95:187-190, 1995

319. R.M.W. Hofstra, T. Stelwagen, B. Pasini, A.Y. van der Veen, B. Ponder, Y. Nakamura, G. Romeo. C.H.C.M. Buys: Ordering of markers in the pericentromeric region of chromosome 10. Human Genetics, 96:116-118, 1995

320. J. Nahmias, N. Horinigold, J. Fitzgibbon, K. Woodward, A. Pilz, D. Griffin, E.P. Henske, Y. Nakamura, S. Graw, F. Florian, F. Benham, S. Povey, and J. Wolfe: Cosmid contigs spanning 9q34 including the candidate region for TSC1. Eur. J. Human Genetics, 3:65-77, 1995

321. M. Litt, P. Kramer, E. Korte, P. Fain, S. Cox, D. Root, R. White, J. Weissenbach, H. Doniskeller, R.Gatti, J. Weber, Y. Nakamura, C. Julier, K. hayashi, N. Supurr, M. Dean, J. Mandel, K. kidd, T. Kruse, A. Retief, A. bale, T. Meo, G. Vergnaud, S. Warren, and H.F. Willard: The CEPH consortium linkage map of human chromosome 11. Genomics, 27:101-112, 1995

322. E. Tsuchiya, R. Furuta, N. Wada, K. Nakagawa, Y. Ishikawa, B. Kawabuchi, Y. Nakamura, and H, Sugano: High K.ros mutation rates in goblet-cell-type adenocarcinomas of the lungs J Cancer Res Clin Oncol,, 122:577-581, 1995

323. N. Hayashi, S. Sugai, I. Ito, S. Nakamori, M. Ogawa, and Y. Nakamura: Ethnic difference in the pattern of K-ras oncogene mutations in human colorectal cancers. Human Mutation, 8:258-261, 1996

324. M. Inoue, M. Isomura, S. Ikekawa, T. Fujiwara, S. Shin, H. Moriya, Y. Nakamura: Isolation and characterization of a human cDNA clone (GCN5L1) homologous to GCN5, a yeast transcription activator. Cytogenetics Cell Genetics, 73:134-136, 1996

325. Y. Furukawa, T. Kawakami, K. Sudo, J. Inazawa, A. Matsumine, T. Akiyama, Y. Nakamura: Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae. Cytogenetics Cell Genetics, 73:130-133, 1996

326. S. Sasaki, A. Horii, M. Shimada, H.-J. Han, A. Yanagisawa, T. Muto, and Y. Nakamura: Somatic Mutations of a Human Mismatch Repair Gene, hMLH1, in Tumors from Patients with Multiple Primary Cancers. Human Mutation, 7:275-278, 1996

327. T. Katagiri, M. Emi, I. Ito, K. Kobayashi, M. Yoshimoto, S. Watanabe, T. Iwase, F. Kasumi, Y. Miki, M.H. Skolnick, and Y. Nakamura: Mutations in the BRCA1 gene in Japanese breast cancer patients. Human Mutation, 7:334-339, 1996

328. H. Saito, T. Fujiwara, S. Shin, K. Okui, and Y. Nakamura: Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2. Cytogenetics Cell Genetics, 72:191-193, 1996

329. T. Ezaki, M. Watanabe, T. Hibi, S. Aiso, K. Ohta, T. Nakajima, A. Yanagisawa, Y. Kato, T. Ariyama, J. Inazawa, Y. Nakamura and A. Horii: Deletion mapping on chromosome 1p in well-differentiated gastric cancer. British Journal of Cancer, 73:424-428, 1996

330. H. Saito, T. Fujiwara, E. Takahashi, S. Shin, and Y. Nakamura: Isolation and mapping of a novel human gene encoding a protein containing zinc-finger structures. Genomics, 31:376-379, 1996

331. K. Koyama, Y. Fukushima, J. Inazawa, N. Takahashi, and Y. Nakamura: The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis Syndrome region in 17p11.2. Cytogenetics Cell Genetics, 72:78-82, 1996

332. M. Isomura, K. Okui, T. Fujiwara, S. Shin, and Y. Nakamura: Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary

gene. Genomics, 32:125-127, 1996 333. H.-J. Han, K. Sudo, J. Inazawa, and Y. Nakamura: Isolation and mapping of a human gene

(RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene. Cytogenetics Cell Genetics, 73:137-139, 1996

334. K. Kobayashi, M. Matsushima, S Koi, H. Saito, S. Sagae, R. Kudo and Y. Nakamura: Mutational analysis of mismatch repair genes, hMLH1 and hMSH2, in sporadic endometrial carcinomas with microsatellite instability. Japanese Journal of Cancer Research, 87:141-145, 1996

335. T. Tanaka, J. Inazawa, and Y. Nakamura: Molecular cloning and mapping of a human cDNA for cytosolic malate dehydrogenase (MDH1). Genomics, 32:128-130, 1996

336. S. Ninomiya, M. Isomura, K, Narahara, Y. Seino, and Y. Nakamura: Isolation of a testis-specific cDNA on chromosome 17q from a region adjacent to the breakpoint of t(12;17) observed in a patient with acampomelic campomelic dysplasia and sex reversal. Human Molecular Genetics, 5:69-72, 1996

337. T. Watanabe, T.Fujiwara, A. Kawai, F. Shimizu, S. Takami, H. Hirano, S. Okuno, K. Ozaki, S. Takeda, M. Nagata, A. Takaichi, E.Takahashi, Y.Nakamura, and S. Shin: Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle. Cytogenetics Cell Genetics, 72:86-89, 1996

338. T. Katagiri, K. Ozaki, T. Fujiwara, F. Shimizu, A. Kawai, S. Okuno, M. Suzuki, Y. Nakamura, E. Takahashi, and Y. Hirai: Cloning, expression and chromosome mapping of adducin-like 70 (ADDL), a human cDNA highly homologous to human erythrocyte adducin. Cytogenetics Cell Genetics, 74:90-95, 1996

339. T. Tokino, T. Urano, T. Furuhata, M. Matsushima, T. Miyatsu, S. Sasaki, and Y. Nakamura: Characterization of the human p57KIP2 gene; Alternative splicing, Insertion/deletion polymorphisms in VNTR sequences in the coding region, and mutational analysis. Human Genetics, 97:625-631, 1996

340. M. Shimada, A. Yanagisawa, Y. Kato, M. Inoue, H. Shiozaki, M. Monden and Y. Nakamura: Genetic machanisms in esophageal carcinogenesis; frequent deletion of 3p and 17p in premalignant lesions. Genes Chromosomes and Cancer, 15:165-169, 1996

341. T. Tanaka, J. Inazawa, Y. Nakamura: Molecular cloning of a human cDNA encoding putative cysteine protease (PRSC1) and its chromosome assignment to 14q32.1. Cytogenetics Cell Genetics, 74:120-123, 1996

342. T. Mori, K. Miura, T. Fujiwara, S. Shin, J. Inazawa, and Y. Nakamura: Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse DIFF6. Cytogenetics Cell Genetics, 73:224-227, 1996

343. K. Okita, T. Tokino, H. Nishimori, K. Miura, H. Nikaido, J. Hayakawa, A. Ono, M. Kuwajima, Y. Matsuzawa and Y. Nakamura: Definition of the locus responsible for systemic carnitine deficiency within a 1.6-cM region of mouse chromosome 11 by detailed linkage analysis. Genomics, 33:289-291, 1996

344. K. Chinen, E. Takahashi, and Y. Nakamura: Isolation and mapping of a novel gene (SEC14L), partially homologous to yeast SEC14, that contains a variable number of tandem repeats (VNTR) site in its 3' untranslated region. Cytogenetics Cell Genetics, 73:218-223, 1996

345. T. Ohta, M. Nakano, T. Tsujita, K. Abe, K. Osoegawa, T. Yamagata, K. Yoshiura, Y. Jinno, E. Soeda, Y. Nakamura, and N. Niikawa: Isolation of a cosmid clone corresponding to an inv(21) breakpoint of a patient with transient abnormal myelopoiesis. Am. J. Human Genetics, 58:544-550, 1996

346. K. Tsukamoto, N. Ito, M. Yoshimoto, T. Iwase, T. Tada, F. Kasumi, Y. Nakamura, and M. Emi: Two distinct commonly deleted regions on chromosome 13q suggest involvement of BRCA2 and retinoblastoma (RB) genes in sporadic breast carcinomas. Cancer, 78:1929-1934, 1996

347. K. Miura, K. Suzuki, T.Tokino, M. Isomura, J.Inazawa, S. Matsuno and Y. Nakamura: Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kb on distal chromosome 9q. Cancer Research, 56:1629-1634, 1996

348. T. Tanaka, A. Ogiwara, I. Uchiyama, T. Takagi, and Y.Nakamura: Construction of a normalized directionally-cloned cDNA library from adult heart and analysis of 3040 clones by partial sequencing. Genomics, 35:231-235, 1996

349. T. Watanabe, F. Shimizu, M. Nagata, A. Kawai, T. Fujiwara, Y. Nakamura, E. Takahashi, Y.Hirai: Cloning, expression, and mapping of CKAP1, which encodes a putative cytoskeleton-associated protein containing a CAP-GLY domain. Cytogenetics Cell Genetics, 72:208-211, 1996

350. K. Ozaki, T. Kuroki, S. Hayashi, and Y. Nakamura: Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. Genomics, 36:316-319, 1996

351. S. Ikegawa, T. Toda, K. Okui and Y. Nakamura: Structure and chromosomal assignment of the human S1-5 Gene (FBNL) that is highly homologous to fibrillin. Genomics, 35:590-592, 1996

352. M. Isomura, K. Okui, T. Fujiwara, S. Shin, and Y. Nakamura: Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS. Cytogenetics Cell Genetics,

74:263-265, 1996 353. K. Ozaki, T. Fujiwara, A. Kawai, F. Shimizu, S. Takami, S. Okuno, S. Takeda, Y. Shimada, M.

Nagata, T. Watanabe, A. Takaichi, E. Takahashi, Y. Nakamura, and S. Shin: Cloning, expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain. Cytogenetics Cell Genetics, 72:242-245, 1996

354. S. Matuda, J.K. Tuzuki, M. Ohsugi, M. Yoshida, M. Emi, Y. Nakamura, Y. Yoshida, A.F. Nishiyama and T. Yamamoto: Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity. Oncogene, 12:705-713, 1996

355. L.A. James, D.J. Ogilvie, K. Yamakawa, Y. Nakamura, C.J. Stirling, and R. Anand: Walking, cloning, and mapping with YACs in 3q27: Localization of five ESTs including three members of the cystatin gene family and identification of CpG island. Genomics, 32:425-430, 1996

356. D. Ichikawa, N. Hashimoto, M. Hoshima, T. Yamaguchi, K. Sawai, Y. Nakamura, T. Takahashi, T. Abe, J. Inazawa: Analysis of numerical aberrations in specific chromosomes by fluorescence in situ hybridization (FISH) as a diagnostic tool in breast cancer. Cancer, 77:2064-2069, 1996

357. A. Matsumine, T. Senda, G-H. Baeg, B.C. Roy, Y. Nakamura, M. Noda, K. Toyoshima, and T. Akiyama: MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase. Journal of Biological Chemistry, 271:10341-10346, 1996

358. Y. Nakamura: Application of DNA markers to clinical genetics. Japanese Journal of Human Genetics, 41:1-10, 1996

359. T. Watanabe, T.Fujiwara, F.Shimizu, S.Okuno, M.Suzuki, E.Takahashi, Y.Nakamura, Y.Hirai: Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q. Cytogenetics Cell Genetics, 73:153-156, 1996

360. S. Ikegawa, Y. Kumano,K. Okui, T. Fujiwara, E. Takahashi and Y. Nakamura: Isolation, characterization and chromosomal assignment of the human WNT7A gene. Cytogenetics Cell Genetics, 74:149-152, 1996

361. Y. Miki, T. Katagiri, F. Kasumi, T. Yoshimoto and Y. Nakamura: Mutation analysis in the BRCA2 gene in primary breast cancers. Nature Genetics, 13:245-247, 1996

362. H.-J. Han, Y. Yuan, J.-L. Ku, J.-H. Oh, Y.-J. Won, K.J. Kang, K.Y. Kim, S. Kim, C.Y. Kim, J.-P. Kim, N.G. Oh, K.H. Lee, K.J. Choe, Y. Nakamura, and J.-G. Park: Germline mutations of hMLH1 and hMSH2 genes in Korean HNPCC, suspected Hereditary Nonpolyposis Colorectal Cancer (HNPCC). J. Natl. Cancer Inst., 88:1317-1319, 1996

363. I. Ishikawa, M. Ozaki, Y. Tominaga, and Y. Nakamura: Cytogenetic abnormalities in renal cell carcinomas associated with uremic aquired renal cystic disease. J. Kanazawa Med. Univ., 21:76-81, 1996

364. K. Wakui, H. Ohashi, A. Yamagishi, S. Hamano, T. Nara, S. Ishikiriyama, Y. Nakamura, and Y. Fukushima: Insertional Duplication 8q22-q24: Report of a case proven by FISH with mapped cosmid probes. American Journal of Medical Genetics, 65:36-39, 1996

365. M. Matsushima, J. Inazawa, E. Takahashi, K. Suzumori, and Y. Nakamura: Molecular cloning and mapping of a human cDNA (SC5DL) encoding a protein homologous to fungal sterol-C5-desaturase. Cytogenetics Cell Genetics, 74:252-254, 1996

366. T. Katagiri, Y. Nakamura, and Y. Miki: Mutations in the BRCA2 gene in hepatocellular carcinomas. Cancer Research, 56:4575-4577, 1996

367. T. Watanabe, F. Shimizu, M. Nagata, A. Takaichi, T. Fujiwara, Y. Nakamura, E. Takahashi, and Y.Hirai: Cloning, expression pattern and mapping to 12p13.2-p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain. Cytogenetics Cell Genetics, 73:214-217, 1996

368. T. Furuhata, T. Urano, T. Tokino, and Y. Nakamura: Isolation of a novel GPI-anchored gene specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivity. Oncogene, 13:1965-1970, 1996

369. T. Toda, M. Miyake, K. Kobayashi, K. Mizuno, K. Saito, M. Osawa, Y. Nakamura, I. Kanazawa, Y. Nakagome, K. Tokunaga, and Y. Nakahori: Linkage disequilibrium mapping narrows the Fukuyama-type congenital muscular dystrophy (FCMD) candidate region to less than 100 kb. Am. J. Human Genetics, 59:1313-1320, 1996

370. F. Shimizu, T.K. Watanabe, T. Fujiwara, E. Takahashi, Y. Nakamura, and H. Maekawa: Isolation and mapping of the human glycoprotein M6 gene (GMP6A) to 4q33 -->q34. Cytogenetics Cell Genetics, 74:138-139, 1996

371. T. Watanabe, A. Kawai, T. Fujiwara, H. Maekawa, Y.Hirai, Y. Nakamura, and E. Takahashi: Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans. Cytogenetics Cell Genetics, 74:146-148, 1996

372. T. Watanabe, T. Fujiwara, Y. Nakamura, Y. Hirai, H. Maekawa, and E. Takahashi: Cytogenet. Cloning, expression pattern and mapping to Xq of NAP1L3, a gene encoding a peptide homologous to human and yeast nucleosome assembly proteins. Cytogenetics Cell Genetics, 74:281-285, 1996

373. S. Saito, S. Sirahama, M. Matsushima, M. Suzuki, S. Sagae, R. Kudo, J. Saito, K. Noda, and Y. Nakamura: Definition of a commonly-deleted region in ovarian cancers to a 300-kb segment of chromosome 6q27. Cancer Research, 15:5586-5589, 1996

374. T. Watanabe, T. Katagiri, M. Suzuki, F. Shimizu, T. Fujiwara, N. Kanemoto, Y. Nakamura, Y. Hirai,

H. Maekawa, and E. Takahashi: Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats. Genomics, 38:273-276, 1996

375. K. Chinen, M. Isomura, K. Izawa, Y. Fujiwara, H. Ohata, T. Iwamasa, and Y. Nakamura: Isolation of 45 exon-like fragments from 8p22 --> p21.3, a region that is commonly deleted in hepatocellular, colorectal, and non-small cell lung carcinomas. Cytogenetics Cell Genetics, 75:190-196, 1996

376. I.P.M. Tomlinson, S. Olschwang, D. Abelovitch, Y. Nakamura,W.F. Bodmer, G. Thomas, and D. Markie: Testing candidate loci on chromosomes 1 and 6 for genetic linkage to Peutz-Jeghers' disease Annals of Human Genetics , 60:377-384, 1996

377. S. Sasaki, T. Tokino, T. Miyatsu, T.Muto and Y. Nakamura: Mutational analysis of the hMLH1 gene using an automated two-dimensional DNA typing system. Human Mutation, 9:164-171, 1997

378. A. Iida, R. Isobe, M. Yoshimoto, T. Iwase, T. Tada, F. Kasumi, Y. Nakamura, and M. Emi: Localization of a breast cancer tumor suppressor gene to a 3-cM interval within chromosomal region 16q22. British Journal of Cancer, 75:264-267, 1997

379. H. Saito, S. Nakatsuru, J. Inazawa, and Y. Nakamura: Frequent association of alternative splicing of NER, a nuclear hormone receptor gene, in cancer tissues. Oncogene, 14:617-621, 1997

380. S. Ishikawa, M. Kai, Y. Takei, K. Kuwata, K. Okui, M. Suzuki, M. Ogawa, and Y. Nakamura: Isolation and mapping of a human zinc finger gene (ZNF188) homologous to ZNF187, a serum-response-element binding protein. Cytogenetics Cell Genetics, 77:185-189, 1997

381. S. Ikegawa, K. Nakamura, A. Nagano, N. Haga, and Y. Nakamura: Mutations in the N-terminal globular domain of the type X collagen gene (COL10A1) In patients with Schmid metaphyseal chondrodysplasia. Human Mutation, 9:131-135, 1997

382. S. Matsumoto, F. Kasumi, G. Sakamoto, M. Onda, Y. Nakamura, and M. Emi: Detailed deletion mapping of chromosome arm 3p in breast cancers: A 2-cM region on 3p14.3-21.1 and a 5-cM region on 3p24.3-25.1 commonly deleted in tumors. Genes Chromosomes and Cancer, 20:268-274, 1997

383. T. Tanaka, R. Nagai, H. Tomoike, S. Takada, K. Yano, K. Yabuta, N. Haneda, O. Nakano, A.Shibata, T.Sawayama, H. Kasai, Y. Yazaki, and Y. Nakamura: Four novel KVLQT1 and four novel HERG mutations in familial long-QT syndrome. Circulation, 95:565-567, 1997

384. K. Suzuki, Y. Daigo, S. Fukuda, T. Tokino, M. Isomura, K. Isono, B. Wainwright, and Y. Nakamura: No evidence of mutation in the human PTC gene, responsible for NBCC syndrome, in human primary squamous cell carcinomas of the esophagus and lung. Japanese Journal of Cancer Research, 88:225-228, 1997

385. JT. Lim, T. Kuroki, K. Ozaki, H. Kohsaki, T. Yamori, T. Tsuruo, S. Nakamori, S. Imaoka, M. Endo, and Y. Nakamura: Isolation of murine and human homologues of the fission-yeast dis3+ gene encoding a mitotic-control protein and its overexpression in cancer cells with progressive phenotypes. Cancer Research, 57:921-925, 1997

386. Y. Kimura, T. Furuhata, T. Urano, K. Hirata, Y. Nakamura, and T. Tokino: Genomic structure and chromosomal localization of GML (GPI-anchored molecule-like protein), a gene induced by p53. Genomics, 41:477-480, 1997

387. S. Ishikawa, M. Kai, M. Tamari, Y. Takei, K Takeuchi, H. Bandou, Y. Yamane, M. Ogawa, and Y. Nakamura: Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line. DNA Research, 4:35-43, 1997

388. Y. Kimura, T. Furuhata, T. Shiratsuchi, H. Nishimori, K. Hirata, Y. Nakamura, and T. Tokino: GML sensitizes cancer cells to Taxol by induction of apoptosis. Oncogene, 15:1369-1374, 1997

389. S. Ishikawa, T. Takahashi, M. Ogawa, and Y. Nakamura: Genomic structure of the human PLCD1 (phospholipase C delta 1) locus on 3p22 --> p21.3. Cytogenetics Cell Genetics, 78:58-60, 1997

390. S. Tamura, S. Nakamori, T. Kuroki, Y. Sasaki, S. Imaoka, H. Furukawa, O. Ishikawa, and Y. Nakamura: Association of cumulative allelic losses with tumor agressiveness in hepatocellular carcinoma. Journal of Hepatology, 27:669-676, 1997

391. Y. Daigo, K. Suzuki, O. Maruyama, Y. Miyoshi, T. Yasuda, T. Kabuto, S. Imaoka, T. Fujiwara, E Takahashi, M. Fujino, and Y. Nakamura: Isolation, mapping, and mutation analysis of a human cDNA homologous to the doc-1 gene of Chinese hamster, a candidate tumor suppressor for oral cancer. Genes Chromosomes and Cancer, 20:204-207, 1997

392. T. Kimura, Y. Arakawa, S. Inoue, Y. Fukushima, I. Kondo, K. Koyama, T. Hosoi, A. Orimo, M. Muramatsu, Y. Nakamura, T. Abe, and J. Inazawa: The brain finger protein gene (ZNF179), a member of the ring finger family, maps within the Smith-Magenis syndrome region at 17p11.2. American Journal of Medical Genetics, 69:320-324, 1997

393. Y. Nakamura:, Cleaning up on β-catenin. (News & Views) Nature Medicine, 3:499-500, 1997 394. Y. Miki, T. Katagiri, and Y. Nakamura: Infrequent Mutation of the H-cadherin Gene on

Chromosome 16q24 in Human Breast Cancers. Japanese Journal of Cancer Research, 88:701-704, 1997

395. S. Takeda, T. Fujiwara, F. Shimizu, A. Kawai, K. Shinomiya, S. Okuno, K. Ozaki, T. Katagiri, Y. Shimada, M. Nagata, T. Watanabe, A. Takaichi, Y. Kuga, M. Shimizu, H. Hishigaki, E. Takahashi, S. Shin, Y. Nakamura, and Y. Hirai: Isolation and mapping of karyopherin alpha3 (KPNA3), a

human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1. Cytogenetics Cell Genetics, 76:87-93, 1997

396. S. Fukuda, H. Kohsaki, S. Hayashi, K.Ozaki, T.Kuroki ,T. Yamori, T. Tsuruo, S. Nakamori, S. Imaoka and Y. Nakamura: Isolation of a novel gene showing a reduced expression in metastatic colorectal carcinoma cell lines and carcionmas. Japanese Journal of Cancer Research, 88:725-731, 1997

397. F. Shimizu, T.K. Watanabe, S. Okuno, Y. Omori, T. Fujiwara, E. Takahashi, and Y. Nakamura: Isolation of a novel human cDNA (rhoHP1) homologous to rho genes. Biochem. Biophy. Acta, 1351:13-16, 1997

398. H. Chen, C. Rossier, Y. Nakamura, A. Lynn, A. Chakravarti, and S. Antonarakis: Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3. Genomics, 41:193-200, 1997

399. T. Urano, H. Nishimori, H.-J. Han, T. Furuhata, Y. Kimura, Y. Nakamura and T. Tokino: Cloning of P2XM, a novel human P2X receptor gene regulated by p53. Cancer Research, 57:3281-3287, 1997

400. H. Nishimori, T. Shiratsuchi, T. Urano, Y. Kimura, K. Kiyono, K. Tatsumi, S. Yoshida, M. Ono, M. Kuwano, Y. Nakamura, T. Tokino: A novel brain-specific p53-target gene, BAI1, containing thrombospondin type1 repeats inhibits experimental angiogenesis. Oncogene, 15:2145-2150, 1997

401. S. Nakamori, M. Kameyama, H. Furukawa, O. Takeda, S. Sugai, S. Imaoka, and Y. Nakamura: Genetic detection of colorectal cancer cells in circulation and lymph nodes. Diseases of Colon and Rectum, 40:s29-s36, 1997

402. M. Nesbit, M. Hodges, L. Campbell, T. de Meulemeester, M. Alders, N. Rodrigues, K. Talbot, A. Theodosiou, M. Mannens, Y. Nakamura, P. Little, and K.E. Davies: Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2. Genomics, 42:284-294, 1997

403. F. Shimizu, T. Katagiri, M. Suzuki, T.K. Watanabe, S. Okuno, Y. Kuga, M. Nagata, T. Fujiwara, Y. Nakamura and E. Takahashi: Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily. Cytogenetics Cell Genetics, 77:261-263, 1997

404. H. Shibata, K. Toyama, H. Shioya, M. Ito, M. Hirota, S. Hasegawa, H. Matsumoto, H. Takano, T. Akiyama, K. Toyoshima, R. Kanamaru, Y. Kanegae, I. Saito, Y. Nakamura, K. Shiba, and T. Noda: Rapid colorectal adenoma formation initiated by conditional targeting of the APC gene. Science, 278:120-123, 1997

405. S. Ikegawa and Y. Nakamura: Structure of the gene encoding human colligin-2 (CBP2). Gene, 194:301-303, 1997

406. T. Yokota, S. Matsumoto, M. Yoshimoto, F. Kasumi, F. Akiyama, G. Sakamoto, Y. Nakamura, and M. Emi: Mapping of a breast cancer tumor supressor gene locus to a 4-cM interval on chromosome 18q21. Japanese Journal of Cancer Research, 88:959-964, 1997

407. M. Nakamoto, H. Takebayashi, Y. Kawaguchi, S. Narumiya, M. Taniwaki, Y. Nakamura, K. Ishikawa, I. Akiguchi, and J. Kimura, A. Kakizuka: A CAG/CTG expansion in the normal population. Nature Genetics, 17:385-386, 1997

408. Y. Nakamura, T. Tokino, M. Isomura, J. Inazawa, T. Aoki, T. Mori, M. Shimada, K. Miura, and K. Suzuki: Multistep carcinogenesis of Esophageal Carcinoma. Molecular Pathology of Gastroenterological Cancer, :15-22, 1997

409. M. Emi, S. Matsumoto, A. Iida, K. Tsukamoto, T. Nakata, T. Yokota, F. Akiyama, G. Sakamoto, M. Yoshimoto, F. Kasumi, and Y. Nakamura: Correlation of allelic losses and clinicopathological factors in primary breast cancers. Breast Cancer, 4:243-246, 1997

410. F. Shimizu, T.K. Watanabe, H. Shimomiya, Y. Nakamura, and T. Fujiwara: Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP). Biochem. Biophy. Acta, 1354:24-28, 1997

411. F. Hosoda, Y. Arai, E. Kitamura, J. Inazawa, M. Fukushima, T. Tokino, Y. Nakamura, C. Jones, N. Kakazu, T. Abe, and M. Ohki: A complete NotI restriction map covering the entire long arm of human chromosome 11. Genes to Cells, 2:345-357, 1997

412. Y. Takahashi, H.Fujita, Y. Nakamura, and H. Kurahashi: Dual-color FISH analysis of Robertsonian translocations. Japanese Journal of Human Genetics, 42:517-523, 1997

413. Y. Yamane, Y. Nakamura, and M. Isomura: Allelic frequencies of twelve dinucleotide repeat marker loci on chromosome 13 in normal Japanese population. Japanese Journal of Human Genetics, 42:533-537, 1997

414. Y. Takei, S. Sasaki, T. Fujiwara, E. Takahashi, T. Muto and Y. Nakamura: Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta. Cytogenetics Cell Genetics, 78:295-300, 1997

415. Y. Omori, H. Kyushiki, S. Takeda, M. Suzuki, A. Kawai, T. Fujiwara, E. Takahashi and Y. Nakamura: Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1. Cytogenetics Cell Genetics, 78:285-288, 1997

416. K. Kagawa, T. Inoue, T. Tokino, Y. Nakamura, and T. Akiyama: Overexpression of GML promotes

radiation-induced cell cycle arrest and apoptosis. Biochemical and Biophysical Research Communications, 241:481-485, 1997

417. T.K. Watanabe, M. Suzuki, Y. Omori, H. Hishigaki, M. Horie, N. Kanemoto, T. Fujiwara, Y. Nakamura, and E. Takahashi: Cloning and characterization of a novel member of the human mad gene family (MADH6). Genomics, 42:446-451, 1997

418. T. Shiratsuchi, H. Nishimori, H. Ichise, Y. Nakamura, and T. Tokino: Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). Cytogenetics Cell Genetics, 79:103-108, 1997

419. S. Ishikawa, M. Kai, Y. Murata, M. Tamari, Y. Daigo, T. Murano, M. Ogawa, and Y. Nakamura: Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene. Journal of Human Genetics, 43:132-134, 1998

420. H. Nagase and Y. Nakamura: Cleavage using Rnase to detect mutations. Mutation Detection, :63-80, 1998

421. M. Itoh, S. Tsukada, T. Orita, J. Nishiu, H. Tomoike, and Y. Nakamura, and T. Tanaka: Identification by differential display of eight known genes induced during in vivo intimal hyperplasia. Journal of Human Genetics, 43:9-13, 1998

422. M. Matsushima, T. Fujiwara, E. Takahashi, T. Minaguchi, Y. Eguchi, Y. Tsujimoto, K. Suzumori, Y. Nakamura: Isolation and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human Nip3. Genes Chromosomes and Cancer, 21:230-235, 1998

423. T. Katagiri, F. Kasumi, M. Yoshimoto, K. Asaishi, R. Abe, A. Tsuchiya, M. Sugano, T. Nomizu, S. Takai, M. Yoneda, K. Nanba, M. Makita, H. Okazaki, K. Hirata, M. Okazaki, Y. Furutsuma, Y. Morishita, Y. Iino, T. Karino, T. Fukutomi, H. Ayabe, S. Hara, T. Kajiwara, S. Houga, T. Shimizu, M. Toda, Y. Yamasaki, T. Uchida, K. Kunitomo, H.Sonoo, J. Kurebayashi, K. Shimotuma, Y. Nakamura, and Y. Miki: High proportion of missense mutations of the BRCA1 and BRCA2 genes in Japanese breast cancer families. Journal of Human Genetics, 43:42-48, 1998

424. A. Okawa, S. Ikegawa, I. Nakamura, S. Goto, H. Moriya, and Y. Nakamura: Mapping of a gene responsible for twy (tip-toe walking Yoshimura), a mouse model of ossification of the posterior longitudinal ligament of the spine (OPLL). Mammalian Genome, 9:155-156, 1998

425. K. Ueda, M. Nishijima, H. Inui, M. Watatani, E. Yayoi, J. Okamura, M. Yasutomi, Y. Nakamura, and Y. Miyoshi: Infrequent mutations in the PTEN/MMAC1 gene among primary breast cancers. Japanese Journal of Cancer Research, 89:17-21, 1998

426. S. Shirahama, K. Ogura, H. Takami, K. Ito, T. Tohsen, A. Miyauchi, and Y. Nakamura: Mutational analysis of the RET proto-oncogene in 71 Japanese patients with medullary thyroid carcinoma. Journal of Human Genetics, 43:101-106, 1998

427. K. Ozaki, M. Nagata, M. Suzuki, T. Fujiwara, Y. Miyoshi, O. Ishikawa, H. Ohigashi, S. Imaoka, E. Takahashi, and Y. Nakamura: Isolation and characterization of a novel human pancreas-specific gene, "pancpin", that is down-regulated in pancreatic cancer cells. Genes Chromosomes and Cancer, 22:179-185, 1998

428. H. Nakagawa, K. Koyama, T. Tanaka, Y. Miyoshi, H. Ando, S. Baba, M. Watatani, M. Yasutomi, M. Monden, and Y. Nakamura: Localization of the gene responsible for Peutz-Jeghers syndrome within a 6-cM region of chromosome 19p13.3. Human Genetics, 102:203-206, 1998

429. J. Nisiu, T. Tanaka, and Y. Nakamura: Isolation and chromosomal mapping of the human homolog of perilipin (PLIN), a rat adipose tissue-specific gene, by differential dsplay method. Genomics, 48:254-257, 1998

430. K. Mori, K. Iwao, Y. Miyoshi, A. Nakagawara, K. Kofu, T. Akiyama, N. Arita, T. Hayakawa and Y. Nakamura: Identification of brain-specific splicing variants of the hDLG1 gene and altered splicing in neuroblastoma cell lines. Journal of Human Genetics, 43:123-127, 1998

431. T. Itoh, T. Tanaka, R. Nagai, T. Kamiya, T. Sawayama, T. Nakayama, H. Tomoike, H. Sakurada, Y.Yazaki, and Y. Nakamura: Genomic organization and mutational analysis of HERG, a gene responsible for familial long QT syndrome. Human Genetics, 102:435-439, 1998

432. M. Emi, M. Matsushima, T. Katagiri, T. Yokota, T. Nakata, F. Kasumi, Y. Miki, M.H. Skolnick and Y. Nakamura: Multiplex mutation screening of the BRCA1 gene in 1000 Japanese breast cancers. Japanese Journal of Cancer Research, 89:12-16, 1998

433. A. Iida, K. Kurose, R. Isobe, F. Akiyama, G. Sakamoto, M. Yoshimoto, F. Kasumi, Y. Nakamura, and M. Emi: Mapping of a new target region of allelic loss to a 2-cM interval at 22q13.1 in primary breast cancer. Genes Chromosomes and Cancer, 21:108-112, 1998

434. T. Nakata, M. Yoshimoto, F. Kasumi, F. Akiyama, G. Sakamoto, Y. Nakamura, and M. Emi: Identification of a new commonly deleted region within a 2-cM interval of 11p11 in breast cancers. Europian Journal of Cancer, 34:417-421, 1998

435. K. Tsukamoto, N. Itoh, M. Yoshimoto, F. Kasumi, F. Akiyama, G. Sakamoto, Y. Nakamura, and M. Emi: Allelic loss on chromosome 1p is associated with progression and lymph node metastasis of primary breast carcinoma. Cancer, 82:317-322, 1998

436. T. Katagiri, H. Saito, A. Shinohara, H. Ogawa, N. Kamada, Y. Nakamura, and Y. Miki: Multiple possible sites of BRCA2 interacting with DNA repair protein Rad51. Genes Chromosomes and Cancer, 21:217-222, 1998

437. K. Iwao, S. Nakamori, M. Kameyama, S. Imaoka, M. Kinoshita, T. Fukui, S. Ishiguro, Y.

Nakamura, and Y. Miyoshi: Activation of the β-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without APC mutations. Cancer Research, 58:1021-1026, 1998

438. S. Yamamoto, M. Okada, M. Tsujikawa, Y. Shimomura, K. Nishida, Y. Inoue, H. Watanabe, N. Maeda, H. Kurahashi, S. Kinoshita, Y. Nakamura, and Y. Tano: A kerato-epithelin (βig-h3) mutation in Lattice corneal dystrophy type IIIA. Am. J. Human Genetics, 62:719-722, 1998

439. N. Kanemoto, H. Hishigaki, A. Miyakita, K. Oga, S. Okuno, A. Tsuji, T. Takagi, E. Takahashi, Y. Nakamura, and T. K. Watanabe: Genetic dissection of "OLETF", a rat model for non-insulin dependent diabetes mellitus. Mammalian Genome, 9:419-425, 1998

440. Y. Takei, S. Ishikawa, T. Tokino, T. Muto and Y. Nakamura: Isolation of a novel tp53 target gene from a colon cancer cell line carrying a highly regulated wild-type tp53 expression system. Genes Chromosomes and Cancer, 23:1-9, 1998

441. H.-J. Han, T. Tokino and Y. Nakamura: CSR, a scavenger receptor-like protein with a protective role against cellular damage caused by UV irradiation and oxidative stress. Human Molecular Genetics, 7:1039-1046, 1998

442. M. Fujimoto, P.N. Kantaputra, S. Ikegawa, Y. Fukushima, S. Sonta, M. Matsuno, T. Ishida, T. Matsumoto, S. Kondo, H. Tomita, H.-X. Deng, M. D'urso, M.M. Rinaldi, V. Ventroto, T. Takagi, Y. Nakamura, and N. Niikawa: The gene for mesomeric dysplasia Kantaputra type is mapped to chromosome 2q24-q32. Journal of Human Genetics, 43:32-36, 1998

443. H. Kurahashi, M. Sakamoto, J. Ono, A. Honda, S. Okada, and Y. Nakamura: Molecular cloning of the chromosomal breakpoint in the LIS1 gene of a patient with isolated lissencephaly and balanced t(8;17). Human Genetics, 103:189-192, 1998

444. T. Aihara, Y. Miyoshi, K. Koyama, M. Suzuki, E. Takahashi, M. Monden, and Y. Nakamura: Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of drosophila ISWI. Cytogenetics Cell Genetics, 81:191-193, 1998

445. Y. Yamane, K. Kogawa, T. Tanaka, Y. Nakamura, and M. Isomura: Heterozygosities and allelic frequencies of 358 dinucleotide-repeat marker loci in the Japanese population. Journal of Human Genetics, 43:165-168, 1998

446. S. Saito, M. Matsushima, S. Sirahama, T. Minaguchi, Y. Kanamori, M. Minami and Y. Nakamura: Complete genomic structure, DNA polymorphisms, and alternative splicing of the human AF-6 Gene. DNA Research, 5:115-120, 1998

447. T. Shiratsuchi, M. Futamura, K. Oda, H. Nishimori, Y. Nakamura, and T. Tokino: Cloning and characterization of BAP1 (BAI-associated protein 1): a PDZ domain-containing protein that interacts with BAI1. Biochemical and Biophysical Research Communications, 247:597-604, 1998

448. H. Nakagawa, K. Koyama, Y. Miyoshi, H. Ando, S. Baba, M. Watatani, M. Yasutomi, N. Matsuura, M. Monden, and Y. Nakamura: Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome. Human Genetics, 103:168-172, 1998

449. T. Itoh, T. Tanaka, R. Nagai, K, Kikuchi, S. Ogawa, S. Okada, S. Yamagata, K. Yano, Y. Yazaki, and Y. Nakamura: Genomic organization and mutational analysis of KVLQT1, a gene responsible for familial long QT syndrome. Human Genetics, 103:290-294, 1998

450. Y. Miyoshi, K. Iwao, Y. Nagasawa, T. Aihara, Y. Sasaki, S. Imaoka, M. Murata, T. Shimano, and Y. Nakamura: Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Research, 58:2524-2527, 1998

451. H.-J. Han, and Y. Nakamura: Dinucleotide repeat polymorphism in the first intron of the CSR gene. Journal of Human Genetics, 43:212-213, 1998

452. Y. Nakamura, K. Koyama, and M. Matsushima: VNTR (variable number of tandem repeat) sequences as transcriptional, translational, or functional regulators. Journal of Human Genetics, 43:149-152, 1998

453. S. Matsuura, H. Tauchi, A. Nakamura, N. Kondo, S. Sakamoto, D. Smeets, C. Weemaes, B.H. Belohradsky, M Oshimura, M Isomura, Y. Nakamura and K. Komatsu: Positional cloning of the gene for Nijimegen breakage syndrome. Nature Genetics, 19:179-181, 1998

454. K. Bando, S. Matsumoto, M. Onda, F. Akiyama, G. Sakamoto, M. Yoshimoto, F. Kasumi, Y. Nakamura, and M. Emi: Frequent allelic loss at 6q26-27 in breast carcinomas of the solid-tubular histologic type. Breast Cancer, 5:127-130, 1998

455. T. Aihara, S. Noguchi, Y. Miyoshi, H. Nakano, Y. Sasaki, Y. Nakamura, and S. Imaoka: Allelic imbalance of insulin-like growth factor II gene expression in cancerous and precancerous lesions of the liver. Hepatology, 28:86-89, 1998

456. O. Maruyama, H. Nishimori, T. Katagiri, Y. Miki, A. Ueno, and Y. Nakamura: Cloning of TCFL5 encoding a novel human basic helix-loop-helix motif protein that is specifically expressed in primary spermatocytes at the pachytene stage. Cytogenetics Cell Genetics, 82:41-45, 1998

457. A. Okawa, I. Nakamura, S. Goto, H. Moriya, Y. Nakamura, and S. Ikegawa: Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nature Genetics, 19:271-273, 1998

458. M.Tamari, Y. Daigo, S, Ishikawa, and Y. Nakamura: Genomic structure of a novel human gene (XYLB) on chromosome 3p22 --> p21.3 encoding a xylulokinase-like protein. Cytogenetics Cell Genetics, 82:101-104, 1998

459. T. Nakajima, T. Furukawa, T. Tanaka, Y. Katayama, R. Nagai, Y. Nakamura, and M. Hiraoka: Novel mechanism of HERG current suppression in LQT2: shift in voltage dependent of HERG inactivation. Circulation Research, 83:415-422, 1998

460. K. Ohgaki, A. Iida, F. Kasumi, G. Sakamoto, M. Akimoto, Y. Nakamura, and M. Emi: Mapping of a new target region of allelic loss to a 6-cM interval at 21q21 in primary breast cancers. Genes Chromosomes and Cancer, 23:244-247, 1998

461. K. Kobayashi, Y. Nakahori, K. Mizuno, M. Miyake, Y. Nakamura, K. Tokunaga and T. Toda: Founder-haplotype analysis in Fukuyama-type congenital muscular dystrophy (FCMD). Human Genetics, 103:323-327, 1998

462. T. Fujiwara, A. Saito, M. Suzuki, H. Shinomiya, T. Suzuki, E. Takahashi, A. Tanigami, A. Ichiyama, C. H. Chung, Y. Nakamura, and K. Tanaka: Identification and cromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease. Genomics, 54:155-158, 1998

463. K. Kurose, A. Iida, T. Araki, G. Sakamoto, F. Kasumi, Y. Nakamura, and M. Emi: Frequent alleleic loss at 7p14-15 associated with aggressive histologic types of breast cancer. Japanese Journal of Cancer Research, 89:533-538, 1998

464. K. Lu, H. Nishimori, Y. Nakamura, K. Shima, M. Kuwajima: A missense mutation of mouse OCTN2, a sodium-dependent carnitine cotransporter, is juvenile visceral steatosis (JVS) mouse. Biochemical and Biophysical Research Communications, 252:590-594, 1998

465. K. Kobayashi, Y. Nakahori, M. Miyake, Y. Nomura, M. Yoshioka, K. Saito, M. Osawa, J. Goto, Y. Nakagome, I. Kanazawa, Y. Nakamura, K. Tokunaga, and T. Toda: An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy (FCMD). Nature, 394:388-392, 1998

466. K. Ozaki, T. Fujiwara, Y. Nakamura, and E. Takahashi: Isolation and mapping of a novel human kidney - and liver- specific gene homologous to the bacterial acetyltransferase. Journal of Human Genetics, 43:255-258, 1998

467. S. Okamoto, M. Matsushima and Y. Nakamura: Identification, genomic organization, and alternative splicing of KNSL3, a novel human gene encoding a kinesin-like protein. Cytogenetics Cell Genetics, 83:25-29, 1998

468. J. Nishiu, T. Tanaka, and Y. Nakamura: Identification of a novel gene (ECM2) encoding a putative extracellular matrix protein expressed predominantly in adipose and female-specific tissues and its chromosomal localization to 9q2.3. Genomics, 52:378-381, 1998

469. K. Ozaki, M. Nagata, M. Suzuki, T. Fujiwara, K. Ueda, Y. Miyoshi, E. Takahashi, and Y. Nakamura: Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoproteins 1 and 2; significantly increased expression in cancers of various tissues. Cancer Research, 58:3499-3503, 1998

470. Y. Ohmori, M. Suzuki, K. Ozaki, Y. Harada, Y. Nakamura, E. Takahashi, and T. Fujiwara: Expression and chromosomal localization of KIAA0369, a putative kinase structually related to Doublecortin. Journal of Human Genetics, 43:169-177, 1998

471. Y. Ariyama, Y. Fukuda, Y. Okuno, M. Seto, K. Date, T. Abe, Y. Nakamura, and J. Inazawa: Amplification on double-minute chromosome and partial-tandem duplication of the MLL gene in leukemic cells of a patient with acute myelogenous leukemia. Genes Chromosomes and Cancer, 23:267-272, 1998

472. T. Nishiwaki, Y. Daigo, M. Tamari, Y.Fujii, and Y. Nakamura: Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters. Cytogenetics Cell Genetics, 83:251-255, 1998

473. M. Sakamoto, J. Ono, S. Okada, M. Masuno, Y. Nakamura, and H. Kurahashi: Alteration of the LIS1 gene in Japanese patients with isolated lissencephaly sequence or Miller-Dieker syndrome. Human Genetics, 103:586-589, 1998

474. M. Tsujikawa, H. Kurahashi, T. Tanaka, M. Okada, S. Yamamoto, N. Maeda, H. Watanabe, Y. Inoue, A. Kiridoshi, K. Matsumoto, Y. Ohishi, S. Kinishita, Y. Shimomura, Y. Nakamura, and Y. Tano: Homozygosity mapping of a gene responsible for gelatinous drop-like corneal dystrophy (GDLD) to chromosome 1p. Am. J. Human Genetics, 63:1073-1077, 1998

475. T. Minaguchi, Y. Kanamori, M. Matsushima, H. Yoshikawa, Y. Taketani, and Y. Nakamura: No evidence of correlation between polymorphism at codon 72 of p53 and risk of cervical cancer in Japanese patients with HPV16/18 infection. Cancer Research, 58:4585-4586, 1998

476. S. Ikegawa, H. Ohashi, K. C. Kim, A. Sannohe, G. Nishimura, M. Kimizuka, Y. Fukushima, T. Nagai, Y. Nakamura: Novel and recurrent COMP (cartilage oligomeric matrix protein) mutations in pseudoachondroplasia and multiple epiphyseal dysplasia. Human Genetics, 103:633-638, 1998

477. H. Nakagawa, Y. Murata, K. Koyama, A. Fujiyama, Y. Miyoshi, M. Monden, T. Akiyama, and Y. Nakamura: Identification of a brain-specific APC homologue, APCL, and its interaction with β-catenin. Cancer Research, 58:5176-5181, 1998

478. Y. Nakamura, J. Inazawa: Genetic diagnosis of cancer. (review) International Journal of Clinical Oncology, 3:265-270, 1998

479. Y. Nakamura:, ATM: the p53 booster. Nature Medicine, 4:231-1232, 1998 480. T. Shiratsuchi, K. Oda, H. Nishimori, M. Suzuki, E. Takahashi, T. Tokino, and Y. Nakamura:

Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein

that interacts with BAI1. Biochemical and Biophysical Research Communications, 251:158-165, 1998

481. Y. Miyoshi, K. Iwao, G. Nawa, H.Yoshikawa, T. Ochi, and Y. Nakamura: Frequent mutations in the -catenin gene in desmoid tumors from patients without familial adenomatous polyposis. Oncology Research, 10:591-594, 1998

482. S. Ikegawa, G. Nishimura, T. Nagai, T. Hasegawa, H. Ohashi, Y. Nakamura: Mutation of the type X collagen gene (COL10A1) causes spondylometaphyseal dysplasia. Am. J. Human Genetics, 63:1659-1662, 1998

483. G. Nawa, T. Urano, T. Tokino, T. Ochi, Y. Miyoshi: Cloning and characterization of the murine P2XM receptor gene. Journal of Human Genetics, 43:262-267, 1998

484. K. Oda, T. Shiratsuchi, H. Nishimori, J. Inazawa, H. Yoshikawa, Y. Taketani, Y. Nakamura, T. Tokino: Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. Cytogenetics Cell Genetics, 84:75-82, 1999

485. H. Tauchi, S. Matsuura, M. Isomura, T. Kinjo, A. Nakamura, S. Sakamoto, N. Kondo, S. Endo, K. Komatsu, and Y. Nakamura: Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1. Genomics, 55:242-247, 1999

486. T. Yokota, M. Yoshimoto, F. Akiyama, G. Sakamoto, F. Kasumi, Y. Nakamura, and M. Emi: Localization of a tumor suppressor gene associated with progression of human breast cancer within a 1-cM interval of 8p22-p23.1. Cancer, 85:447-452, 1999

487. T. Katagiri, M. Futamura, and Y. Nakamura: A Gln/Arg polymorphism at codon 349 of the hBUBR1 gene. Journal of Human Genetics, 44:131-132, 1999

488. K. Iwao, Y. Miyoshi, G. Nawa, H. Yoshikawa, T. Ochi, and Y. Nakamura: Frequent beta-catenin abnormalities in bone and soft-tissue tumors. Japanese Journal of Cancer Research, 90:205-209, 1999

489. K. Kyo, M. Parkes, Y. Takei, H. Nishimori, H. Nagawa, S. Baba, T. Muto, G. M. Lathrop, Y. Nakamura: Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene, MUC3. Human Molecular Genetics, 8:307-311, 1999

490. I. Smith, M.A. Narang, T. Evans, C. Heimann, Y. Nakamura, G. Chenevix-Trech, T. Pietsvh, C. Wicking, and B.J. Wainwright: Isolation and characterization of human Patched 2 (PTCH2), a putative tumor suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32. Human Molecular Genetics, 8:291-297, 1999

491. M. Tamari, Y. Daigo, and Y. Nakamura: Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3. Journal of Human Genetics, 44:116-120, 1999

492. G. Nawa, Y. Miyoshi, H. Yoshikawa, T. Ochi, and Y. Nakamura: Frequent loss of expression or aberrant alternative splicing of P2XM, a p53-inducible gene, in soft-tissue tumors. British Journal of Cancer, 80:1185-1189, 1999

493. T. Watanabe, M.-T. Bihoreau, L. C. McCarthy, S. L. Kiguwa, H. Hishigaki, A. Tsuji, J. Browne, Y.Yamasaki, A, Mizoguchi-Miyakita, K. Oga, T. Ono, S. Okuno, N. Kanemoto, E. Takahashi, H. Hayashi, M. Adachi, C. Webber, M. Davis, S.Kiel, C. Knights, A. Smith, R. Critcher, J. R. Hudson, Jr., T. Day, Y. Irie, T. Takagi, Y. Nakamura, P. N. Goodfellow, G. M. Lathrop, A. Tanigami, and M. R. James: A radiation hybrid map of the rat genome containing 5,255 markers. Nature Genetics, 22:27-36, 1999

494. I. Nakamura, A. Okawa, S. Ikegawa, K. Takaoka and Y. Nakamura: Genomic organization, mapping, and polymorphisms of the gene encoding human cartilage intermediate layer protein (CILP). Journal of Human Genetics, 44:203-205, 1999

495. Y. Daigo, M. Isomura, T. Nishiwaki, M. Tamari, S. Ishikawa, M. Kai, Y. Murata, K. Takeuchi, Y. Yamane, R. Hayashi, M. Minami, M. A. Fujino, Y. Hojo, I. Uchiyama, T. Takagi, and Y. Nakamura: Characterization of a 1,200-kb genomic segment of chromosome 3p22-p21.3. DNA Research, 6:37-44, 1999

496. T. Imazu, S. Shimizu, S. Tagami, M. Matsushima, Y. Nakamura, T. Miki, A. Okuyama, and Y. Tsujimoto: Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with Bcl-2/Bcl-XL and induces apoptosis by altering mitochondrial membrane permiability. Oncogene, 18:4523-4529, 1999

497. O. Watanabe, K. Natori, M. Tamari, Y.Shiomoto, S.Kubo, and Y. Nakamura: Significantly elevated expression of PF4 (platelet factor 4) and eotaxin in the NOA mouse, a model for atopic dermatitis. Journal of Human Genetics, 45:173-176, 1999

498. S. Ikegawa, M. Isomura, Y. Koshizuka and Y. Nakamura: Cloning and characterization of ASH2L and Ash21, human and mouse homologs of the Drosophila ash2 gene. Cytogenetics Cell Genetics, 84:167-172, 1999

499. M. Futamura, H. Nishimori, T. Shiratsuchi, S. Saji, Y. Nakamura, T. Tokino: Molecular cloning, mapping, and characterization of a novel human gene, MTA1-L1, showing homology to a metastasis-associated gene, MTA1. Journal of Human Genetics, 44:52-56, 1999

500. M. Tsujikawa, H. Kurahashi, T. Tanaka, K. Nishida, Y. Shimomura, Y. Tano, and Y. Nakamura: Identification of the gene responsible for gelatinous drop-like corneal dystrophy. Nature Genetics,

21:420-423, 1999 501. Y. Daigo, T. Nishiwaki, T. Kawasoe, M. Tamari, E. Tsuchiya, and Y. Nakamura: Molecular cloning

of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3. Cancer Research, 59:1966-1972, 1999

502. T. Nishiwaki, Y. Daigo, T. Kawasoe, Y. Nagasawa, H. Ishiguro, M. Fujita, Y. Furukawa and Y. Nakamura: Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family. Journal of Human Genetics, 44:197-202, 1999

503. T. Sakabe, T. Shinomiya, T. Mori, Y. Ariyama, Y. Fukuda, T. Fujiwara, Y. Nakamura, and J. Inazawa: Identification of a novel gene, MASL1, within an amplicon at 8p23.1 detected in malignant fibrous histiocytomas by comparative genomic hybridization. Cancer Research, 59:511-515, 1999

504. C. Sakakura, T. Mori, T. Sakabe, Y. Ariyama, T. Shinomiya, K. Date, A. Hagiwara, T. Yamaguchi, T. Takahashi, Y. Nakamura, T. Abe, and J. Inazawa: Gains, losses, and amplification of genomic materials in primary gastric cancers analyzed by comparative genomic hybridization. Genes Chromosomes and Cancer, 24:299-305, 1999

505. T. Shinomiya, T. Mori, Y. Ariyama, T. Sakabe, Y. Fukuda, Y. Murakami, Y. Nakamura, and J. Inazawa: Comparative genomic hybridization of squamous cell carcinomas of the esophagus: the possible involvement of the DPI gene in the 13q34 amplicon. Genes Chromosomes and Cancer, 24:337-344, 1999

506. K. Fukino, A. Iida, A. Teramoto, G. Sakamoto, F. Kasumi, Y. Nakamura and M. Emi: Frequent allelic loss at the TOC locus on 17q25.1 in promary breast cancers. Genes Chromosomes and Cancer, 24:345-350, 1999

507. T. Minaguchi, M. Matsushima, S. Saito, Y. Kanamori, S. Shirahama, S. Okamoto, M. Minami, Y. Taketani, and Y. Nakamura: Complete DNA sequence and characterization of a 330-kb VNTR-rich region on chromosome 6q27 that is commonly deleted in ovarian cancer. DNA Research, 6:131-136, 1999

508. T. Mori, Y. Fukuda, H. Kuroda, T. Matsumura, S. Ota, T. Sugimoto, Y. Nakamura, and J. Inazawa: Cloning and characterization of a novel rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdois tumors. Biochemical and Biophysical Research Communications, 254:594-600, 1999

509. H. Nakagawa, K. Koyama, S. Nakamori, M. Kameyama, S. Imaoka, M. Monden, Y. Nakamura: Frameshift mutation of the STK11 gene in a sporadic gastrointestinal cancer with microsatellite instability. Japanese Journal of Cancer Research, 90:633-637, 1999

510. M. Emi, M. Yoshimoto, T. Sato, S. Matsumoto, T. Iwase, I. Ito, K. Minobe, T. Tada, T. Katagiri, K. Bando, F. Akiyama, Y. Harada, K. Fukino, G. Sakamoto, M. Matsushima, A. Iida, H. Saito, F. Kasumi and Y. Nakamura: Allelic losses at 1p34, 13q12, 17p13.3 and 17q21.1 correlates with poor postoperative prognosis in breast cancer. Genes Chromosomes and Cancer, 26:134-141, 1999

511. K. Ueda, Y. Miyoshi, T. Tokino, M. Watatani, and Y. Nakamura: Induction of apoptosis in T98G glioblastoma cells by transfection of GML, a p53-target gene. Oncology Research, 11:125-132, 1999

512. S. Ikegawa, M. Masuno, Y. Kumano, A. Okawa, M. Isomura, K. Koyama, K. Okui, K. Imaizumi, and Y. Nakamura: Cloning of translocation breakpoints associated with Shwachman syndrome and identification of a candidate gene. Clinical Genet., 55:466-472, 1999

513. I. Nakamura, S. Ikegawa, A. Okawa, S. Okuda, Y. Koshizuka, H. Kawaguchi, K. Nakamura, T. Koyama, S. Goto, J. Toguchida, M. Matsushita, T. Ochi, K.Takaoka, and Y. Nakamura: Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL). Human Genetics, 104:492-497, 1999

514. S. Ikegawa, M. Isomura, Y. Koshizuka, and Y. Nakamura: Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9. Cytogenetics Cell Genetics, 85:227-231, 1999

515. Y. Nagasawa, Y, Miyoshi, K, Iwao, Y. Shinomura, Y. Matsuzawa, and Y. Nakamura: Transformation and morphological changes of murine L cells by transfection with a mutated form of β-catenin. Cancer Research, 59:3539-3542, 1999

516. Y. Onouchi, H. Kurahashi, H. Tajiri, S. Ida, S. Okada, and Y. Nakamura: Genetic alterations in the JAG1 gene in Japanese patients with Alagille syndrome. Journal of Human Genetics, 44:235-239, 1999

517. M. Ui, M. Takada, T. Arai, K. Matsumoto, K. Yamada, T. Nakahata, T. Nishiwaki, Y. Furukawa, T. Tokino, Y. Nakamura, and H. Iba: Retrovirus vectors designed for efficient transduction of cytotoxic or cytostatic genes. Gene Therapy, 6:1670-1678, 1999

518. S. Ikegawa, M. Isomura, Y. Koshizuka, and Y. Nakamura: Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes. Journal of Human Genetics, 44:337-342, 1999

519. C.-C. Ng, K. Koyama, S. Okamura, H. Kondoh, Y. Takei, and Y. Nakamura: Isolation and characterization of a novel p53-inducible gene, TP53TG3. Genes Chromosomes and Cancer,

26:329-335, 1999 520. Y. Daigo, Y. Furukawa, T. Kawasoe, M. Fujita, H. Ishiguro, S. Sugai, S. Nakamori and Y.

Nakamura: Absence of genetic alteration at codon 531 of the human c-src gene in 479 advanced colorectal cancers from Japanese patients. Cancer Research, 59:4222-4224, 1999

521. M. Nishizaki, T. Fujiwara, T. Tanida, A. Hizuta, H. Nishimori, T. Tokino, Y. Nakamura, M. Bouvet, J.A. Roth, and N. Tanaka: Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect. Clinical Cancer Research, 5:1015-1023, 1999

522. H. Nakagawa, K. Koyama, M. Monden, and Y. Nakamura: Analysis of APCL, a brain-specific APC homologue, for mutations and expression in brain tumors. Japanese Journal of Cancer Research, 90:982-986, 1999

523. Y. Kanamori, M. Matsushima, T. Minaguchi, K. Kobayashi, S. Sagae, R. Kudo, N. Terakawa, and Y. Nakamura: Correlation between expression of the matrix metalloprotease-1 (MMP-1) gene in ovarian cancers and an insertion/deletion polymorphism in its promoter region. Cancer Research, 59:4225-4227, 1999

524. Y. Daigo, M. Isomura, T. Nishiwaki, K. Suzuki, O. Maruyama, K. Takeuchi, Y. Yamane, R. Hayashi, M. Minami, Y. Hojo, I. Uchiyama, T.Takagi, and Y. Nakamura: Significant differences in the frequency of transcriptional units, types and numbers of repetitive elements, GC content, and the number of CpG islands between a 1,010-kb G-band genomic segment on chromosome 9q31.3 and a 1,200-kb R-band genomic segment on chromosome 3p21.3. DNA Research, 6:227-233, 1999

525. T. Tanaka, and Y. Nakamura: Mutational analysis of familial long QT syndrome in Japan. Potassium Ion Channels, 46:103-116, 1999

526. T. Minaguchi, T. Mori, Y. Kanamori, M. Matsushima, H. Yoshikawa, Y. Taketani, and Y. Nakamura: Growth suppression of human ovarian cancer cells by adenovirus-mediated transfer of the PTEN gene. Cancer Research, 59:6063-6067, 1999

527. T. Yokota, M. Yoshimoto, F. Akiyama, G. Sakamoto, F. Kasumi, Y. Nakamura, M. Emi: Frequent multiplication of chromosomal region 8q24.1 associated with aggressive histologic types of breast cancers. Cancer Letters, 139:7-13, 1999

528. C. Sakakura, A. Hagiwara, H. Taniguchi, T. Yamaguchi, H. Yamagishi, K.Koyama, Y. Nakamura, T. Abe, and J. Inazawa: Chromosomal aberations in human hepatocellular carcinomas associated with hepatitis C virus infection detected by comparative genomic hybridization. British Journal of Cancer, 80:2034-2039, 1999

529. T. Nakajima, T. Furukawa, Y. Hirano, T. Tanaka, H. Sakurada,T. Takahashi, R. Nagai, T. Itoh, Y. Katayama, Y. Nakamura, and M. Hiraoka: Voltage-shift of the current activation in HERG S4 mutation (R534C) in LQT2. Cardiovascular Research, 44:283-293, 1999

530. E. Kondo-Iida, K. Kobayashi, M. Watanabe, J. Sasaki, T. Kumagai, H. Koide, K. Saito, M. Ozawa, Y. Nakamura, and T. Toda: Novel mutations and genotyoe-phenotype relationships in 107 families with Fukuyama-type congenital muscular dystrophy (FCMD). Human Molecular Genetics, 8:2303-2309, 1999

531. K. Natori, M. Tamari, O. Watanabe, Y. Onouchi, Y. Shiomoto, S. Kubo and Y. Nakamura: Mapping of a gene responsible for dermatitis of NOA (Naruto Research Institute Otsuka Atrichia) mice, an animal model of allergic dermatitis. Journal of Human Genetics, 44:372-376, 1999

532. M. Nishihara, M. Terada, J. Kamogawa, Y. Ohashi, S. Mori, S. Nakatsuru, Y. Nakamura, and M. Nose: Genetic basis of autoimmune siladenitis in MRL/lpr lupus-prone mice. Arthritis & Rheumatism, 42:2616-2623, 1999

533. M. Isomura, S. Ikegawa, T. Kinjo, K. Takeuchi, Y. Yamane-Tanaka, K. Kitami, and Y. Nakamura: Sequence analysis of a total of three megabases of DNA in two regions of chromosome 8p. DNA Research, 6:387-400, 1999

534. M. Suzuki, T. Watanabe, T. Fujiwara, Y. Nakamura, E. Takahashi, and A. Tanigami: Molecular cloning, expression, and mapping of a novel human cDNA, GRP17, highly homologous to human gadd45 and murine MyD118. Journal of Human Genetics, 44:300-303, 1999

535. A. Saito, K. Ozaki, T. Fujiwara, Y. Nakamura, and A. Tanigami: Isolation and mapping of a human lung-specific gene, TSA1902, encoding a novel chitinase family member. Gene, 239:325-331, 1999

536. S. Nakatsuru, M. Terada, M. Nishihara, J. Kamogawa, T. Miyazaki, W.-M. Qu, K. Morimoto, C. Yazawa, H. Ogasawara, Y. Abe, K. Fukui, G. Ichien, M. Ito, S. Mori, Y. Nakamura, and M. Nose: Genetics dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice. Pathology International, 49:974-982, 1999

537. K. Minobe, K. Bando, K. Fukino, S. Soma, F. Kasumi, G. Sakamoto, K. Furukawa, K. Higuchi, M. Onda, Y. Nakamura, and M. Emi: Somatic mutation of the PTEN/MMAC1 gene in breast cancers with microsatellite instability. Cancer Letters, 144:9-16, 1999

538. K. Tsukamoto, M. Yoshimoto, F. Kasumi, F. Akiyama, G. Sakamoto, Y. Nakamura, and M. Emi: Frequent multiplication of chromosome 1q in non-invasive and papillotubular carcinoma of the breast. Cancer Letters, 141:21-28, 1999

539. M. Emi, Y. Utada, M. Yoshimoto, T. Sato, S. Matsumoto, T. Iwase, I. Ito, K. Minobe, T. Tada, T. Katagiri, K. Bando, F. Akiyama, Y. Harada, K. Fukino, G. Sakamoto, M. Matsushima, A. Iida, H.

Saito, F. Kasumi and Y. Nakamura: Correlation of allelic loss with poor postoperative survival in breast cancer. Breast Cancer, 6:351-356, 1999

540. S. Kunishima, T. Kojima, T. Tanaka, T. Kamiya, K. Ozawa, Y. Nakamura, and H. Saito: mapping of a gene for May-Hegglin anomaly to chromosome 22q. Human Genetics, 105:379-383, 1999

541. S. Okamura, C. Ng Ching, K. Koyama, Y. Takei, M. Monden, and Y. Nakamura: Identification of seven genes regulated by wild-type p53 in a colon-cancer cell line carrying a well-controled wild-type p53 expression system. Oncology Research, 11:281-285, 1999

542. T. Mori, H. Arakawa, T. Tokino, K. Mineura, and Y. Nakamura: Significant increase of adenovirus infectivity in glioma cell lines by extracellular domain of hCAR. Oncology Research, 11:513-521, 1999

543. H. Tomita, S. Nagamitsu, K. Wakui, Y. Fukushoma, K. Yamada, M. Sadamatsu, A. Masui, T. Konishi, T. Matsuishi, M. Aihara, K. Shimizu, K. Hashimoto, H. Mineta, M. Matsushima, T. Tsujita, M. Saito, H. Tanaka, S. Tsuji, T. Takagi, Y. Nakamura, S. Nanko, N. Kato, Y. Nakane, and N. Niikawa: Paroximal kinesigenic choreoathetosis locus maps to chromosome 16p11.2-q12.1. Am. J. Human Genetics, 65:1688-1697, 1999

544. S. Okuno, T.K. Watanabe, T. Ono, Y. Yamasaki, Y. Goto, H. Miyao, T. Asai, N. Kanemoto, K. Ogawa, A. Mizoguchi-Miyatake, T. Takagi, E. Takahashi, Y. Nakamura, and A. Tanigami: Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats. Genomics, 62:350-355, 1999

545. T.K. Watanabe, S. Okuno, K. Oga, A. Mizoguchi-Miyakita, A. Tsuji, Y. Yamasaki, H. Hishigaki, N. Kanemoto, T. Takagi, E. Takahashi, Y. Irie, Y. Nakamura, A. Tanigami: Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: Quantitative trait locus analysis of (OLETF x BN) x OLETF. Genomics, 58:233-239, 1999

546. N. Ide, Y. Hata, H. Nishioka, K. Hirao, I. Yao, M. Deguchi, A. Mizoguchi, H. Nishimori, T. Tokino, Y. Nakamura, and Y. Takai: Localization of membrane-associated guanylate kinase (MAGI)-1/BAI-associated protein (BAP) 1 at tight junctions of epithelial cells. Oncogene, 18:7810-7815, 1999

547. Y. Harada, K. Ozaki, M. Suzuki, T. Fujiwara, E. Takahashi, Y. Nakamura, A. Tanigami: Complete cDNA sequence and genomic organization of a human pancreas-specific gene homologous to Caenorhabditis elegans sel-1. Journal of Human Genetics, 44:330-336, 1999

548. Y. Ariyama, T. Mori, T. Shinomiya, T. Sakabe, Y. Fukuda, A. Kanamaru, Y. Yamada, M. Isobe, M. Seto, Y. Nakamura, J. Inazawa: Chromosomal imbalances in adult T-cell leukemia revealed by comparative genomic hybridization: gains at 14q32 and 2p16-22 in cell lines. Journal of Human Genetics, 44:357-363, 1999

549. Y. Utada, S. Haga, T. Kajiwara, F. Kasumi, F. Akiyama, G. Sakamoto, Y. Nakamura, and M. Emi: Allelic loss at the 8p22 region as a prognostic factor in large and estrogen receptor negative breast carcinomas. Cancer, 88:1410-1416, 2000

550. Y. Utada, S. Haga, T. Kajiwara, F. Kasumi, F. Akiyama, G. Sakamoto, Y. Nakamura, and M. Emi: Mapping of target regions of allelic loss in primary breast cancers to 1-cM intervals on genomic contigs at 6q21 and 6q25.3. Japanese Journal of Cancer Research, 91:293-300, 2000

551. S. Isaka, Y. Takei, T. Tokino, Y. Miyoshi, K. Koyama, M. Suzuki, E. Takahashi, C. Azuma, Y. Murata, and Y. Nakamura: Isolation and characterization of a nobel TP53-inducible gene, TP53TG5, which suppresses growth and shows cell cycle-dependent transition of expression. Genes Chromosomes and Cancer, 27:345-352, 2000

552. T. Tokino and Y. Nakamura: The role of p53-target genes in human cancer. Crinical reviews in Oncology/Hematology, 33:1-6, 2000

553. H. Nakagawa, K. Koyama, Y. Murata, M. Morito, T. Akiyama,and Y. Nakamura: EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue. Oncogene, 19:210-216, 2000

554. T. Nishiwaki, Y. Daigo, T. Kawasoe, and Y. Nakamura: Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32. Genes Chromosomes and Cancer, 27:169-176, 2000

555. H. Akashi, H.-J. Han, M. Iizaka, Y. Nakajima, S. Sugano, K. Imai and Y. Nakamura: Isolation and characterization of a human cDNA encoding a protein homologous to the 7.2-kDa protein (subunit X) of bovine ubiquinol-cytochrome C reductase. Journal of Human Genetics, 45:43-46, 2000

556. H. Nakagawa, K. Koyama, Y. Murata, M. Morito, T. Akiyama, Y. Nakamura: APCL, a CNS-specific homologue of APC, Binds to p53-Binding protein 2 and translocates it to the perinucleus. Cancer Research, 60:101-105, 2000

557. T. Kinjo, M. Isomura, T. Iwamasa, and Y. Nakamura: Molecular cloning and characterization of two novel genes on chromosome 8p21.3. Journal of Human Genetics, 45:12-17, 2000

558. M. Iizaka, H.-J. Han, H. Akashi, Y. Nakajima, S. Sugano, M. Ogawa, and Y. Nakamura: Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins. Cytogenetics Cell Genetics, 88:221-224, 2000

559. C. Kihara, T. Seki, Y. Furukawa, H. Yamana, Y. Kimura, P. van Schaardenburgh, K. Hirata, and Y. Nakamura: Mutations in zinc-binding domains of p53 as a prognostic marker of

esophageal-cancer patients. Japanese Journal of Cancer Research, 91:190-198, 2000 560. H. Akashi, H.-J. Han, M. Iizaka, Y. Nakajima, Y. Furukawa, S. Sugano, K. Imai and Y. Nakamura:

Isolation and characterization of a novel gene encoding a putative seven-span transmembrane protein, TM7SF3. Cytogenetics Cell Genetics, 88:305-309, 2000

561. T. Oyama, Y. Miyoshi, K. Koyama, H. Nakagawa, T. Yamori, T. Ito, H. Matsuda and Y. Nakamura: Isolation of a novel gene on human chromosome 8p21.3-p22 whose expression is reduced significantly in human colorectal cancers with liver metastasis. Genes Chromosomes and Cancer, 29:9-15, 2000

562. S. Satoh, Y. Daigo, Y. Furukawa, T. Katoh, N. Miwa, T. Nishiwaki, T. Kawasoe, H. Ishiguro, M. Fujita, T. Tokino, Y. Sasaki, S. Imaoka, M. Murata, T. Shimano, Y. Yamaoka, and Y. Nakamura: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nature Genetics, 24:245-250, 2000

563. R. Yamada, T. Tanaka, Y. Ohnishi, K. Suematsu, M. Minami, T. Seki, S. Tohma, K. Yamamoto, Y. Nakamura: Identification of 142 single nucleotide polymorphisms in 41 candidate genes for rheumatoid arthritis in the Japanese population. Human Genetics, 106:293-297, 2000

564. Y. Ohnishi, T. Tanaka , R. Yamada , K. Suematsu, M. Minami, K. Fujii , N. Hoki , K. Kodama , S. Nagata , T. Hayashi , N. Kinoshita , H Sato, H. Sato, T. Kuzuya, H. Takeda, M. Hori, and Y. Nakamura: Identification of 187 single nucleotide polymorphisms (SNPs) among 41 candidate genes for ischemic heart disease in the Japanese population. Human Genetics, 106:288-292, 2000

565. M. Futamura, H. Arakawa, K. Matsuda, T. Katagiri, S. Saji, Y. Miki and Y. Nakamura: Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1. Cancer Research, 60:1531-1535, 2000

566. H. Iwasa, T. Itoh, R. Nagai, Y. Nakamura, and T. Tanaka: Twenty single nucleotide polymorphisms (SNPs) and their alleleic frequencies in four genes that are responsible for familial long QT syndrome in the Japanese population. Journal of Human Genetics, 45:182-183, 2000

567. M. Unoki, S. Furuta, Y. Onouchi, O. Watanabe, S. Doi, H. Fujiwara, A. Miyatake, K. Fujita, M. Tamari and Y. Nakamura: Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: Positive association of a T924C polymorphism in the thromboxane A2 receptor gene. Human Genetics, 106:440-446, 2000

568. Z.-Q. Yang, M.A. Yoshida, Y. Fukuda, N. Kurihara, Y. Nakamura, and J. Inazawa: Molecular cytogenetic analysis of 17 renal cancer cell lines: Increased copy number at 5q31-33 in cell lines from nonpapillary carcinomas. Japanese Journal of Cancer Research, 91:156-163, 2000

569. H. Tanaka, H. Arakawa, T. Yamaguchi, K. Shiraishi, S. Fukuda, K. Matsui, Y. Takei, and Y. Nakamura: A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint DNA damage. Nature, 404:42-49, 2000

570. H. Ishiguro, Y. Furukawa, Y. Daigo, Y. Miyoshi, Y. Nagasawa, T. Nishiwaki, T. Kawasoe, M. Fujita, S. Satoh,１ N. Miwa, Y. Fujii, and Y. Nakamura: Isolation and characterization of human NBL4, a gene involved in the β-catenin/Tcf signaling pathway. Japanese Journal of Cancer Research, 91:597-603, 2000

571. Y.-M. Lin, T. kato, S. Satoh, Y. Nakamura and Y. Furukawa: Identification of novel polymorphisms in the AXIN1 and CDX-2 genes. Journal of Human Genetics, 45:254-256, 2000

572. K. Shiraishi, S. Fukuda, T. Mori, K. Matsuda, T. Yamaguchi, C. Tanikawa, M. Ogawa, Y. Nakamura and H. Arakawa: Identification of fractalkine, a CX3C-type chemokine, as a direct target of p53. Cancer Research, 60:3722-3726, 2000

573. L. C. McCarthy, M.-T. Bihoreau, S. L. Kiguwa, J. Browne, T. K. Watanabe, H. Hishigaki, A. Tsuji, S. Kiel, C. Webber, M. E. Davis, C. Knights, A. Smith, R. Critcher, P. Huxtall, J. R. Hudson, Jr., T. Ono, H. Hayashi, T. Takagi, Y. Nakamura, A. Tanigami, P. N. Goodfellow, G. M. Lathrop and M. R. James: A whole-genome radiation hybrid panel andframework map of the rat genome. Mammalian Genome, 11:791-795, 2000

574. T. Kawasoe, Y. Furukawa, Y. Daigo, T. Nishiwaki, H. Ishiguro, M. Fujita, S. Satoh, N. Miwa, Y. Nagasawa, Y. Miyoshi, M. Ogawa and Y. Nakamura: Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by β-catenin. Cancer Research, 60:3354-3358, 2000

575. M. Nakanishi, C. Sakakura, Y. Fujita, R. Yasuoka, H. Aragane, K. Koide, A. Hagiwara, T. Yamaguchi, Y. Nakamura, T. Abe, J. Inazawa, and H. Yamagishi: Genomic alterations in primary gastric cancers analyzed by comparative genomic hybridization and clinicopathological factors. Hepato-Gastroenterology, 47:658-662, 2000

576. T.K. Watanabe, T. Ono, S. Okuno, A. Mizoguchi-Miyashita, Y. Yamasaki, N. Kanemoto, H. Hishigaki, K. Oga, E. Takahashi, Y. Irie, M. Bihoreau, M. R. James, G.M. lathrop, T. Takagi, Y. Nakamura, and A. Tanigami: Characterization of newly developed SSLP markers for the rat. Mammalian Genome, 11:300-305, 2000

577. M. Higashiyama, Y. Miyoshi, K. Kodama, H. Yokouchi, K. Takami, M. Nishijima, T. Nakayama, H. Kobayashi, K. Minamigawa, and Y. Nakamura: p53-regulated GML gene expression in non-small cell lung cancer: a promising relationship to cisplatin chemosensitivity. Europian Journal of Cancer, 36:489-495, 2000

578. M. Horie, Y. Mitsumoto, H. Kyushiki, N. Kanemoto, A. Watanabe, Y. Taniguchi, N. Nishino, T. Okamoto, M. Kondo, T. Mori, K. Noguchi, Y. Nakamura, E. Takahashi, and A. Tanigami: Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons. Genomics, 67:146-152, 2000

579. M. Murata, K. Iwao, Y. Miyoshi, Y. Nagasawa, M. Yabu, S. Himeno, K. Imanishi, M. Ohsawa, H. Wada, S. Tominaga, T. Shimano, T. Kobayashi, and Y. Nakamura: Activation of β-catenin gene by interstitial deletions involving exon 3 as an early event in colorectal tumorigenesis. Cancer Letters, 159:73-78, 2000

580. H. Akashi, H.-J. Han, M. Iizaka, and Y. Nakamura: Growth-suppressive effect of NSAIDs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. International Journal of Cancer, 88:873-880, 2000

581. T. Yamauchi, M. Tada, K. Houkin. T. Tanaka, Y. Nakamura, S. Kuroda, H. Abe. T. Inoue, K. Ikezaki, T. Matsushima, M. Fukui: Linkage of familial Moyamoya disease (spotaneous occlusion of the circle of Willis) to chromosome 17q25. Stroke, 31:930-935, 2000

582. S. Matsumoto, K. Minobe, Y. Utada, K. Furukawa, M. Onda, G. Sakamoto, F. Kasumi, Y. Nakamura, and M. Emi: Loss of heterozygosity at 3p24-p25 as a prognostic factor in breast cancer. Cancer Letters, 152:63-69, 2000

583. W.-M. Qu, T. Miyazaki, M. Terada, L.-M. Lu, M. Nishihara, A. Yamada, S. Mori, Y. Nakamura, H. Ogasawara, C. Yazawa, S. Nakatsuru, and M. Nose: Genetic dissection of vasculitis in MRL/lpr lupus mice: a novel susceptibility locus involving the CD72c Allele. Eur. J. Immunolo., 30:2027-2037, 2000

584. M. Murata, K. Iwao, Y. Miyoshi, Y. Nagasawa, T. Ohta, K. Shibata, K. Oda, H. Wada, S. Tominaga, Y. Matsuda, M. Ohsawa, Y. Nakamura and T. Shimano: Molecular and biological analysis of carcinoma of the small intestine: βcatenin gene mutation by interstitial deletion involving exon 3 and replication error phenotype. Am. J. Gastroenterology, 95:1576-1580, 2000

585. K. Ono, T. Tanaka, T. Tsunoda, O. Kitahara, C. Kihara, A. Okamoto, K. Ochiai, T. Takagi, and Y. Nakamura: Identification by cDNA microarray of genes Involved in ovarian carcinogenesis. Cancer Research, 60:5007-5011, 2000

586. T. Seki, T. Tanaka, and Y. Nakamura: Genomic structure and multiple single-nucleotide polymorphisms (SNPs) of the thiopurine S-methyltransferase (TPMT) gene. Journal of Human Genetics, 45:299-302, 2000

587. K. Oda, H. Arakawa, T. Tanaka, K. Matsuda, C. Tanikawa, T. Mori, H. Nishimori, K. Tamai, T. Tokino, Y. Nakamura, and Y. Taya: p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell, 102:849-862, 2000

588. K. Yamada, H. Tomita, K. Yoshiura, S. Kondo, K. Wakui, Y. Fukushima, S. Ikegawa, Y. Nakamura, T. Amemiya, and N. Niikawa: An autosomal dominant posterior polar cataract locus maps to human chromosome 20p12-q12. Eur. J. Human Genetics, 8:535-539, 2000

589. Y. Utada, M. Emi, S. Haga, M. Yoshomoto, F. Kasumi, F. Akiyama, G. Sakamoto, S. Haga, T. Kajiwara, and Y. Nakamura: Allelic loss at 1p34-36 predict poor prognosis in node-negative breast cancer. Clinical Cancer Research, 6:3193-3198, 2000

590. Z.-Q. Yang, I. Imoto, Y. Fukuda, A. Pimkhaokham, Y. Shimada, M. Imamura, S. Sugano, Y. Nakamura, and J. Inazawa: Identification of a novel gene, GASC1, with an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines. Cancer Research, 60:4735-4739, 2000

591. M.-S. Wu, K. Tani, H. Sugiyama, H. Hibino, K. Izawa, T. Tanabe, Y. Nakazaki, H. Ishii, J. Ohashi, H. Hohjoh, T. Iseki, A. Tojo, Y. Nakamura, Y. Tanioka, K. Tokunaga, and S. Asano: MHC (Major Histocompatibility Complex)-DRB genes and polymorphisms in common marmoset. Journal of Molecular Evolution, 51:214-222, 2000

592. A. Pimkhaokham, Y. Shimada, Y. Fukuda, N. Kurihara, I. Imoto, Z.-Q. Yang, M. Imamura, Y. Nakamura, and J. Inazawa: Nonrandoom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon. Japanese Journal of Cancer Research, 91:1126-1133, 2000

593. J. Sasaki, K. Ishikawa, K. Kobayashi, E. Kondo-Iida, M. Fukuyama, H. Mizusawa, S. Takashima, Y. Sasakihara, Y. Nakamura, and T. Toda: Neuronal expression of the fukutin gene. Human Molecular Genetics, 9:3083-3090, 2000

594. M.E. Nita, S.K. Ono-Nita, N. Tsuno, O. Tominaga, T. Takenoue, E. Sunami, J. Kitayama, Y. Nakamura, and H. Nagawa: Bcl-XL antisense sensitizes human colon cancer cell line to 5-fluorouracil. Japanese Journal of Cancer Research, 91:825-832, 2000

595. T. Nakajima, M. Kutabayashi, Y. Ohyama, Y. Kaneko, T. Furukawa, T. Itoh, Y. Taniguchi, T. Tanaka, Y. Nakamura, M. Hiraoka, and R. Nagai: Characterization of S818L mutation in HERG c-terminus in LQT2; Modification of activation-deactivation gating properties. FEBS Letters, 481:197-203, 2000

596. M. Fujita, Y. Furukawa, Y. Nagasawa, M. Ogawa and Y. Nakamura: Down-regulation of monocyte chemotactic protein-3 (MCP-3) by activated β-catenin. Cancer Research, 60:6683-6687, 2000

597. F. Kasai, E. Takahashi, K. Koyama, K. Terao, Y. Suto, K. Tokunaga, Y. Nakamura, and M. Hirai: Comparative FISH mapping of the ancestral fusion point of human chromosome 2. Chromosome

Research, 8:727-735, 2000 598. H. Ohigashi, O. Ishikawa, Y. Sasaki, T. Yamada, H. Furukawa, S. Imaoka, T. Kasugai, S. Ishiguro,

K. Ueda, Y. Miyoshi, and Y. Nakamura: K-ras point mutation in the nerve plexuses around the superior mesenteric artery in respectable adenocarcinoma of the pancreatic head. Arch Surg., 135:1450-1455, 2000

599. S. Ikegawa, M. Sano, Y. Koshizuka, and Y. Nakamura: Isolation, characterization, and mapping of the mouse and human PRG4 (proteoglycan 4) genes. Cytogenetics Cell Genetics, 90:291-297, 2000

600. Y. Fukuda, N. Kurihara, I. Imoto, K. Yasui, M. Yoshida, K. Yanagihara, J.G. Park, Y. Nakamura, J. Inazawa: CD44 is a potential target of amplification within the 11p13 amplicon detected in gastric cancer cell lines. Genes Chromosomes and Cancer, 29:315-324, 2000

601. M. Kato, K. Yano, F. Matsuo, H. Saito, T. Katagiri, H. Kurumizaka, M. Yoshimoto, F. Kasumi, F. Akiyama, G. Sakamoto, H. Nagawa, Y. Nakamura, and Y. Miki: Identification of Rad51 alteration in patients with bilateral breast cancer. Journal of Human Genetics, 45:133-137, 2000

602. M. Sakamoto, J. Ono, S. Okada, Y. Nakamura, and H. Kurahashi: Genetic alteration of the DCX gene in Japanese patients with subcortical laminar heterotopia or isolated lissencephaly sequence. Journal of Human Genetics, 45:167-170, 2000

603. Y. Nakatsuru, K. Minami, A. Yoshikawa, JJ. Zhu, H. Oda, P. Masahito, N. Okamoto, Y. Nakamura, T. Ishikawa: Eel WT1 sequence and expression in spontaneous nephroblastomas in Japanese eel. Gene, 245:245-251, 2000

604. A. Iida, M. Emi, R. Matsuoka, E. Hiratsuka, K. Okui, H. Ohashi, J. Inazawa, Y. Fukushima, T. Imai, Y. Nakamura: Identification of a gene disrupted by inv(11)(q3.5;q25) in a patient with leftright axis malformation. Human Genetics, 106:277-287, 2000

605. S. Ikegawa, H. Ohashi, T. Ogata, A. Honda, M. Tsukahara, T. Kubo, M. Kimizuka, M. Shimode, T. Hasegawa, G. Nishimura, Y. Nakamura: Novel and Recrrent EBP Mutations in X-Linked Dominant Chondrodysplasia Punctata. American Journal of Medical Genetics, 94:300-305, 2000

606. T. Toda, K. Kobayashi, E. Kondo-Iida, J. Sasaki, and Y. Nakamura The Fukuyama congenital muscular dystrophy story (review article) Neuromuscular Disorders, 10:153-159, 2000

607. A. Nishikawa, K. Kobayashi, S. Sagae, S. Ishioka, A. Nishikawa, Y. Kanamori, T. Minaguchi, Y. Nakamura, T. Tokino, and R.Kudo: A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter in endometrial carcinomas Japanese Journal of Cacner Research, 91:612-615, 2000

608. C. Sakakura, A. Hagiwara, R. Yasuoka, Y. Fujita, M. Nakanishi, K. Masuda, A. Kimura, Y. Nakamura, J. Inazawa, T. Abe, H. Yamagishi: Amplification and over-expression of the AIB1 nuclear receptor co-activator gene in primary gastric cancers. International Journal of Cancer, 89:217-223, 2000

609. A. Hirano, Y. Utada, S. Haga, T. Kajiwara, G. Sakamoto, F. Kasumi, Y. Nakamura, and M. Emi: Allelic losses as prognostic markers for breast cancers. International Journal of Clinical Oncology, 6:6-12, 2001

610. K. Kyo, T. Muto, H. Nagawa, G. M. Lathrop, and Y. Nakamura: Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease. Journal of Human Genetics, 46:5-20, 2001

611. H. Iwasa, M. Kurabayashi, R. Nagai, Y. Nakamura, and T. Tanaka: Multiple single-nucleotide polymorphisms (SNPs) in the Japanese population in six candidate genes for long QT syndrome. Journal of Human Genetics, 46:158-162, 2001

612. O. Kitahara, Y. Furukawa, T. Tanaka, C. Kihara, K. Ono, R. Yanagawa, E. M. Nita, H. Ogasawara, J. Okutsu, H. Zenbutsu, N. Shiraishi, T. Takagi, Y. Nakamura, and T. Tsunoda: Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after laser-capture microdissection of tumor tissues and normal epithelia. Cancer Research, 61:3544-3549, 2001

613. T. Itoh, K. Kikuchi, Y. Odagawa, S. Takata, K. Yano, S. Okada, N. Haneda, S. Ogawa, O. Nakano, Y. Kawahara, H. Kasai, T. Nakayama, T. Fukutomi, H. Sakurada, A. Shimizu, Y. Yazaki, R. Nagai, Y. Nakamura, and T. Tanaka: Correlation of genetic etiology with response to β-adrenergic blockade among symptomatic patients with familial long-QT syndrome. Journal of Human Genetics, 46:38-40, 2001

614. S. Takeoka, M. Unoki, Y. Onouchi, S. Doi, H. Fujiwara, A. Miyatake, K. Fujita, Ituro Inoue, Y. Nakamura, and M. Tamari: Amino-acid substitutions in the IKAP gene product significantly increase risk for bronchial asthma in children. Journal of Human Genetics, 46:57-63, 2001

615. R. Yamada, T. Tanaka, M. Unoki T. Nagai, T. Sawada, Y. Ohnishi, T, Tsunoda, M. Yukioka, A. Maeda, K. Suzuki, H. Tateishi, T. Ochi, Y. Nakamura, and K. Yamamoto: Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to the disease. Am. J. Human Genetics, 68:674-685, 2001

616. M. Matsushima-Nishiu, M. Unoki, K. Ono, T. Tsunoda, T. Minaguchi, H. Kuramoto, M. Nishida, T. Satoh, T. Tanaka, and Y. Nakamura: Growth and gene expression profiles analyses of endometrial cancer cells expressing exogenous PTEN. Cancer Research, 61:3741-3749, 2001

617. T. Kato, S. Satoh, H. Okabe, O. Kitahara, K. Ono, C. Kihara, T. Tanaka, T. Tsunoda, Y. Yamaoka, Y. Nakamura, and Y. Furukawa: Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis. Neoplasia, 3:4-9, 2001

618. C. Suzuki, M. Unoki, and Y. Nakamura: Identification and allelic frequencies of novel single-nucleotide polymorphisms in the DUSP1 and BTG1 genes. Journal of Human Genetics, 46:155-157, 2001

619. H. Okabe, S. Satoh, T. Kato, O. Kitahara, R. Yanagawa, Y. Yamaoka, T. Tsunoda, Y. Furukawa and Y. Nakamura: Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Research, 6:2129-2137, 2001

620. T. Watanabe, S. Okuno, T. Ono, Y. Yamasaki, K. Oga, A. Mizoguchi-Miyakita, H. Miyano, M. Suzuki, H. Momota, Y. Goto, H. Shinomiya, H. Hishigaki, I. Hayashi, T. Asai, S. Wakitani, T. Takagi, Y. Nakamura, and A. Tanigami: Single-allele correction of the Dmo1 locus in congenic animals substantially attenuates obesity, dyslipidaemia and diabetes phenotypes of the OLETF rat. Clin. and Exp. Pharmacology and Psysiology, 28:28-42, 2001

621. A. Iida, A. Sekine, S. Saito, Y. Kitamura, T. Kitamoto, S. Osawa, C. Mishima and Y. Nakamura: Catalog of 320 single nucleotide polymorphisms (SNPs) in 20 quinone oxidoreductase and sulfotransferase genes. Journal of Human Genetics, 46:225-240, 2001

622. O. Watanabe, M. Tamari, K. Natori, Y. Onouchi, Y. Shiomoto, I. Hiraoka and Y. Nakamura: Loci on murine chromosomes 7 and 13 that modify the phenotype of the NOA mouse, an animal model of atopic dermatitis. Journal of Human Genetics, 46:221-224, 2001

623. A. Sekine, S. Saito, A. Iida, Y. Mitsunobu, S. Higuchi, S. Harigae, and Y. Nakamura: Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2, AANAT, ARD1 and L1CAM in the Japanese population. Journal of Human Genetics, 46:314-319, 2001

624. S. Saito, A. Iida, A. Sekine, C. Eguchi, Y. Miura, and Y. Nakamura: Seventy genetic variations in human microsomal and soluble epoxide hydrolase genes (EPHX1 and EPHX2) in the Japanese population. Journal of Human Genetics, 46:325-329, 2001

625. K. Kobayashi, J. Sasaki, E. Kondo-Iida, Y. Fukuda, M. Kinoshita, Y. Sunada, Y. Nakamura, and T. Toda: Structural organization, complete genomic sequences and mutational analyses of the Fukuyama-type congenital muscular dystrophy gene, fukutin. FEBS Letters, 489:192-196, 2001

626. A. Hirano, M. Emi, M. Tsuneizumi, Y. Ueda, M. Yoshimoto, F. Kasumi, F. Akiyama, G. Sakamoto, S. Haga, T. Kajiwara, and Y. Nakamura: Allelic losses of loci at 3p25.1, 8p22, 13q12, 17p13.3 and 22q13 correlate with postoperative recurrence in breast cancer. Clinical Cancer Research, 7:876-882, 2001

627. Y. Nakamura: Isolation of disease-associated genes through genome analysis and their clinical application. The Keio Journal of Medicine, 50:134-140, 2001

628. A. Iida, S. Saito, A. Sekine, T. Kitamoto, Y. Kitamura, C. Mishima, S. Osawa, K. Kondo, S. Harigae, and Y. Nakamura: Catalog of 434 single-nucleotide polymorphisms (SNPs) in genes of the alcohol dehydrogenase, glutathione S-transferase, and nicotinamide ademine dinucleotide, reduced (NADH) ubiquinone oxidoreductase families. Journal of Human Genetics, 46:385-407, 2001

629. H. Ishiguro, T. Tsunoda, T. Tanaka, Y. Fujii, Y. Nakamura, and Y. Furukawa: Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney. Oncogene, 20:5062-5066, 2001

630. M. Unoki and Y. Nakamura: Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Oncogene, 20:4457-4465, 2001

631. C. Kihara, T. Tsunoda, T. Tanaka, H. Yamana, Y. Furukawa, K. Ono, O. Kitahara, H. Zenbutsu, R. Yanagawa, K. Hirata, T. Takagi, and Y. Nakamura: Prediction of sensitivity of esophageal tumors to adjuvant chemotherapy by cDNA microarray analysis of gene-expression profiles. Cancer Research, 61:6474-6479, 2001

632. Y. Furukawa, T. Kawasoe, Y. Daigo, T. Nishiwaki, H. Ishiguro, M. Takahashi, J. Kitayama, and Y. Nakamura: Isolation of a novel human gene, ARHGAP9, encoding a Rho-GTPase activating protein. Biochemical and Biophysical Research Communications, 284:643-649, 2001

633. Y.-M. Lin, K. Ono, S. Satoh, H. Ishiguro, M. Fujita, N. Miwa, T. Tanaka, T. Tsunoda, Y. Nakamura, and Y. Furukawa: Identification of AF17 as a downstream gene of the β-catenin/T-cell factor pathway and its involvement in colorectal carcinogenesis. Cancer Research, 61:6345-6349, 2001

634. M. Furuhashi, K. Yagi, H. Yamamoto, Y. Furukawa, S. Shimada, Y. Nakamura, A. Kikuchi, K. Miyazono, and M. Kato: Axin facilitates Smad3 activation in the transforming growth factor-β signaling pathway. Molecular and Cellular Biology, 21:5132-5141, 2001

635. R. Yanagawa, Y. Furukawa, T. Tsunoda, O. Kitahara, K. Murata, O. Ishikawa, and Y. Nakamura: Genome-wide screening of genes showing altered expression in liver metastases of human colorectal cancers by cDNA microarray. Neoplasia, 3:395-401, 2001

636. Y. Ohnishi, T. Tanaka, K. Ozaki, R. Yamada, H. Suzuki and Y. Nakamura: A high-throughput SNP typing system for genome-wide association studies. Journal of Human Genetics, 46:471-477, 2001

637. H. Iwasa, M. Kurabayashi, R. Nagai, Y. Nakamura, T. Tanaka: Genetic variations in five genes involved in the excitement of cardiomyocytes. Journal of Human Genetics, 46:549-552, 2001

638. S. Saito, A. Iida, A. Sekine, Y. Miura, T. Sakamoto, C. Ogawa, S. Kawauchi, S. Higuchi, and Y. Nakamura: Identification of 197 genetic variations in six human methyltransferase genes in the Japanese population. Journal of Human Genetics, 46:529-537, 2001

639. S. Okamura, H. Arakawa, T. Tanaka, H. Nakanishi, C. C. Ng, Y. Taya, M. Monden, and Y. Nakamura: p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Molecular Cell, 8:85-94, 2001

640. A. Iida, S. Saito, A. Sekine, Y. Kitamura, K. Kondo, C. Mishima, S. Osawa, S. Harigae, and Y. Nakamura: High-density single-nucleotide polymorphism (SNP) map of the 150-kb region corresponding to the human ATP-binding cassette transporter A1(ABCA1) gene. Journal of Human Genetics, 46:522-528, 2001

641. M. Fujita, Y. Furukawa, T. Tsunoda, T. Tanaka, M. Ogawa and Y. Nakamura: Up-regulation of the ENC1 (ectodermal-neural cortex 1) gene, a downstream target of the β-catenin/T-cell factor complex, in colorectal carcinomas. Cancer Research, 61:7722-7726, 2001

642. Y. Suzuki, H. Taira, T. Tsunoda, J. Mizushima-Sugano, J. Sese, H. Hata, T. Ota, T. Isogai, T. Tanaka, S. Morishita, K. Okubo, Y. Sakaki, Y. Nakamura, A. Suyama, and S. Sugano: Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO reports, 2:388-393, 2001

643. S. Okuno, T. K. Watanabe, T. Ono, K. Oga, A. Mizoguchi-Miyakita, Y. Yamasaki, Y. Goto, H. Shinomiya, H. Momota, H. Miyano, I. Hayashi, T. Asai, M. Suzuki, Y. Harada, H. Hishigaki, S. Wakitani, T. Takagi, Y. Nakamura, and A. Tanigami: Effects of Dmo1 on obesity, dyslipiaemia and hyperglycemia in the Otsuka Long Evans Tokushima Fatty strain. Genet. Res., 77:183-190, 2001

644. Y. Suzuki, T. Tsunoda, J. Sese, H. Taira, J. Mizushima-Sugano, H. Hata, T. ota, T. Isogai, T. tanaka, Y. Nakamura, A. Suyama, Y. Sakaki, S. Morishita, K. Okubo, and S. Sugano: Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Research, 11:677-684, 2001

645. K. Yasui, I. Imoto, Y. Fukuda, A. Pimkhaokham, Z.Q. Yang, T. Naruto, Y. Shimada, Y. Nakamura, J. Inazawa: Identification of target genes within an amplicon at 14q12-q13 in esophageal squamous cell carcinoma. Genes Chromosomes and Cancer, 32:112-118, 2001

646. C. Sakakura, A. Hagiwara, R. Yasuoka, Y. Fujita, M. Nakanishi, K. Masuda, K. Shimomura, Y. Nakamura, J. Inazawa, T. Abe, H. Yamagishi: Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. British Journal of Cancer, 84:824-831, 2001

647. A. Iida, S. Saito, A. Sekine, S. Harigae, S. Osawa, C. Mishima, K. Kondo, Y. Kitamura, and Y. Nakamura: Catalog of 46 single nucleotide polymorphisms (SNPs) in the microsomal glutathione S-transferase 1 (MGST1) gene. Journal of Human Genetics, 46:590-594, 2001

648. A. Iida, Y. Ohnishi, K. Ozaki, Y. Ariji, A. Inose, M. Takahashi, Y. Nakamura, and T. Tanaka: High-density single-nucleotide polymorphism (SNP) map in the 96-kb region containing the entire human DiGeorge syndrome critical region 2 (DGCR2) gene at 22q11.2. Journal of Human Genetics, 46:604-608, 2001

649. Y. Yamanaka, M. Tamar, T. Nakahata and Y. Nakamura: Gene-expression profiles of human small airway epithelial cells treated with low doses of 14- and 16-membered macrolides. Biochemical and Biophysical Research Communications, 287:198-203, 2001

650. A. Iida, S. Saito, A. Sekine, C. Mishima, K. Kondo, Y. Kitamura, S. Harigae, S. Osawa, and Y. Nakamura: Catalog of 258 single nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins. Journal of Human Genetics, 46:668-683, 2001

651. M. Murata, Y. Miyoshi, M. Ohshima, K. Shibata, T. Ohta, Y. Imai, M. Nishikawa, K. Iwao, H. Tateishi, T. Shimano, T. Kobayashi, and Y. Nakamura: Accumulation of β-catenin in the cytoplasm and the nuclei during the early hepatic tumorigenesis. Hepatology Research, 21:126-135, 2001

652. M. Murata, Y. Miyoshi, K. Iwao, H. Wada, K. Shibata, H. Tateishi, T. Shimano, M. Ohsawa, Y. Imai, M. Nishikawa, T. Kobayashi, and Y. Nakamura: Combined hepatocellular/cholangiocellular carcinoma with sarcomatoid features: genetic analysis for histogenesis. Hepatology Research, 21:220-227, 2001

653. N. Miwa, M. Furuse, S. Tsukita, N. Niikawa, Y. Nakamura and Y. Furukawa: Involvement of Claudin-1 in the β-catenin /Tcf signaling pathway and its frequent up-regulation in human colorectal cancers. Oncology Research, 12:469-476, 2001

654. T. Yamaguchi, K. Matsuda, Y. Sagiya, M. Iwadate, M. A. Fujino, Y. Nakamura, and H. Arakawa: p53R2-dependent pathway for DNA synthesis in a p53-regulated cell-cycle checkpoint. Cancer Research, 61:8256-8262, 2001

655. S. Haga, M. Emi, A. Hirano, Y. Utada, T. Kajiwara, F. Akiyama, G. Sakamoto, K. Takahashi, T. Tada, F. Kasumi, and Y. Nakamura: Association of allelic losses at 3p25.1, 13q12 or 17p13.3 woth poor prognosis in breast cancers with lymph node metastasis. Japanese Journal of Cancer

Research, 92:1199-1206, 2001 656. M. Tsuneizumi, M. Emi, H. Nagai, H. Harada, G. Sakamoto, F. Kasumi,S. Inoue, T. Kazui and Y.

Nakamura: Overexpression of the EBAG9 gene at 8q23 associated with early-stage breast cancer. Clinical Cancer Research, 7:3526-3532, 2001

657. O. Guittet, P. Haansson, N. Voevodskaya, S. Fridd, A. Gralund, H. Arakawa, Y. Nakamura, and L. Thelander: Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells. Journal of Biological Chemistry, 276:40647-40651, 2001

658. S. Iwashita, K. Koyama, and Y. Nakamura: VNTR sequence on human chromosome 11p15 that affects transcriptional activity. Journal of Human Genetics, 46:717-721, 2001

659. H. Nakagawa, R.-B.Chadwick, P. Peltomaki, C. Plass, Y. Nakamura, A. de la Chapelle: Loss of imprinting of the insulin-like growth factor Ⅱ gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer. Proc. Natl. Acad. Sci. USA, 98:591-596, 2001

660. Y. Koshizuka, S. Ikegawa, M. Sano, K. Nakamura, and Y. Nakamura: Isolation of novel mouse genes associated with ectopic osscification by differential display method using ttw, a mouse model for ectopic ossification. Cytogenetics Cell Genetics, 94:163-168, 2001

661. Y. Koshizuka, S. Ikegawa, M. Sano, K. Nakamura, Y. Nakamura: Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family. Genomics, 72:252-259, 2001

662. M. Aoki, M. Tamatani, M. Taniguchi, A. Yamaguchi, Y. Bando, K. Kasai, Y. Miyoshi, Y. Nakamura, M.P. Viteke, M. Tohyam, H. Tanaka, and H. Sugimoto: Hypothermic treatment restores glucose regulated protein 78 (GRP78) expression in ischemic brain. Molecular Brain Research, 95:117–128, 2001

663. G.J. Liefers, R.A.E.M. Tollenaar, Y. Nakamura and C.J.H. van de Velde: Genetic cancer syndromes and large-scale gene expression analysis: applications in surgical oncology. (Review) European Journal of Surgical Oncology, 27:343-348, 2001

664. The Japan Society of Human Genetics, Council Committee of Ethics, I. Matsuda, N. Niikawa, K. Sato, K. Suzumori, Y. Fukushima, N, Fujiki, I. Kanazawa, Y. Nakamura, S. Yonemoto, and Y. Nakagome: Guidelines for genetic testing Journal of Human Genetics, 46:163-165, 2001

665. T. Mori, Y. Anazawa, M. Iiizumi, S. Fukuda, Y. Nakamura, and H. Arakawa: Identification of the interferon regulatory factor 5gene (IRF-5) as a direct target for p53. Oncogene, 21:2914-2918, 2002

666. K. Ochi, T. Mori, Y. Toyama, Y. Nakamura and H. Arakawa: Identification of semaphorin3B as a direct target of p53. Neoplasia, 4:82-87, 2002

667. K. Matsuda, K. Yoshida, Y. Taya, K. Nakamura, Y. Nakamura, H. Arakawa: p53AIP1 regulates the mitochondrial apoptotic pathway. Cancer Research, 62:2883-2889, 2002

668. M. Iiizumi, H. Arakawa, .T Mori, A. Ando, and Y. Nakamura: Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex. Cancer Research, 62:1246-1250, 2002

669. A. Iida, S. Saito, A. Sekine, K. Kondo, C. Mishima, Y. Kitamura, S. Harigae, S. Osawa, and Y. Nakamura: Thirteen single nucleotide polymorphisms (SNPs) in the alcohol dehydrogenase 4 (ADH4) gene locus. Journal of Human Genetics, 47:74-76, 2002

670. S. Dan, T. Tsunoda, O. Kitahara, R. Yanagawa, H. Zembutsu, T. Katagiri, K. Yamazaki, Y. Nakamura, and T. Yamori: An integrated database of chemosensitivity to 55 anticancer drugs and gene expression profiles of 39 human cancer cell lines. Cancer Research, 62:1139-1147, 2002

671. A. Iida, S. Saito, A. Sekine, C. Mishima, Y. Kitamura, K. Kondo, S. Harigae, S. Osawa, and Y. Nakamura: Catalog of 77 single nucleotide polymorphisms (SNPs) in the carbohydrate sulfotransferase 1 (CHST1) and carbohydrate sulfotransferase 3 (CHST3) genes. Journal of Human Genetics, 47:14-19, 2002

672. H. Zembutsu, Y. Ohnishi, T. Tsunoda, Y. Furukawa, T. Katagiri, Y. Ueyama, N. Tamaoki, T. Nomura, O. Kitahara, R. Yanagawa, K. Hirata, and Y. Nakamura: Genome-wide cDNA microarray screening to correlate gene-expression profiles with sensitivity of 85 human-cancer xenografts to anticancer drugs. Cancer Research, 62:518-527, 2002

673. M. Hirakawa, T. Tanaka, Y. Hashimoto, M. Kuroda, T. Takagi, and Y. Nakamura: JSNP: a database of common gene variations in the Japanese population. Nucleic Acids Research, 30:158-162, 2002

674. S. Saito, A. Iida, A. Sekine, Y. Miura, C. Ogawa, S. Kawauchi, S. Higuchi, and Y. Nakamura: 326 genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. Journal of Human Genetics, 47:38-50, 2002

675. T. Takei, A. Iida, K. Nitta, T. Tanaka, Y. Ohnishi, R. Yamada, S. Maeda, T. Tsunoda, S. Takeoka, K. It o, K. Honda, K. Uchida, K. Tsuchiya, Y. Suzuki, T. Fujioka, T. Ujiie, Y. Nagane, S. Miyano, I. Narita, F. Gejyo, H. Nihei, Y. Nakamura: Association between single-nucleotide polymorphisms in selectin genes and IgA nephropathy. Am. J. Human Genetics, 70:781-786, 2002

676. M. Doi, A. Nagano and Y. Nakamura: Genome-wide screening by cDNA microarray of genes associated with matrix mineralization by human mesenchymal stem cells in vitro. Biochemical

and Biophysical Research Communications, 290:381-390, 2002 677. H. Yamanaka, N. Hashimoto, K. Koyama, H. Nakagawa, Y. Nakamura, and K. Noguchi:

Expression of Apc2 during mouse development. Gene Expression Patterns, 1:107-114, 2002 678. M. Tsuneizumi, M. Emi, A. Hirano, Y. Utada, K. Tsumagari, K. Takahashi, F. Kasumi, F. Akiyama,

G. Sakamoto, T. Kazui and Y. Nakamura: Assocaition of allelic loss at 8p22 with poor prognosis amang breast cancer cases treated with high-dose adjuvant chemotherapy. Cancer Letters, 180:75-82, 2002

679. M. Tachikawa, Y. Nagai, K .Nakamura, K. Kobayashi, T. Fujiwara, H-J. Han, Y. Nakabayashi, Y. Ichikawa, J. Goto, I. Kanazawa, Y. Nakamura, and T. Toda: Identification of CAG repeat-containing genes expressedin human brain as candidate genes for autosomal dominant spinocerebellar ataxias and other neurodegenerative diseases. Journal of Human Genetics, 47:275-278, 2002

680. T. Nagahata, A. Hirano, Y. Utada, S. Tsuchiya, K. Takahashi, T. Tada, M. Makita, F. Kasumi, F. Akiyama, G. Sakamoto, Y. Nakamura, and M. Emi: Correlation of allelic losses and clinicopathological factors in 504 primary breast cancers. Breast Cancer, 9:208-215, 2002

681. D.G. Duda, M. Sunamura, L. Lozonshi, T. Yokoyama, T. Yatsuoka, A. Horii, K. Tani, S. Asano, Y. Nakamura, and S. Matsuno: Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. British Journal of Cancer, 86:490-496, 2002

682. Y. Sasaki, S. Ishida, I. Morimoto, T. Yamashita, T. Kojima, C. Kihara, T. Tanaka, K. Imai, Y. Nakamura, and T. Tokino: The p53 family member genes are involved in the notch signal pathway. Journal of Biological Chemistry, 277:719-724, 2002

683. M. Iizaka, Y. Furukawa, T. Tsunoda, H. Akashi, M. Ogawa, and Y. Nakamura: Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochemical and Biophysical Research Communications, 292:498-512, 2002

684. K. Miura, E. D. Bowman, R. Simon, A. C. Peng, A. I. Robles, R. T. Jones, T. Katagiri, P. He, H. Mizukami, L. Charboneau, T. Kikuchi, L. A. Liotta, Y. Nakamura, and C. C. Harris: Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles. Cancer Research, 62:3244-3250, 2002

685. J. Kamogawa, M.Terada, S. Mizuki, M, Nishihara, H. Yamamoto, S, Mori, Y. Abe, K. Morimoto, S. Nakatsuru, Y. Nakamura, and M. Nose: Arthritis in MRL/lpr Mice Is Under the Control of Multiple Gene Loci With an Allelic Combination Derived From the Original Inbred Strains. Arthritis & Rheumatism, 46:1067-1074, 2002

686. T. Mori, Y. Anazawa, K. Matsui, S. Fukuda, Y. Nakamura, and H. Arakawa: Cyclin K as a direct transcriptional target of the p53 tumor suppressor. Neoplasia, 4:268-274, 2002

687. S. Saito, A. Iida, A. Sekine, Y. Miura, C. Ogawa, S. Kawauchi, S. Higuchi, and Y. Nakamura: Identification of 779 genetic variations in eight genes encoding members of the ATP-binding cassette, subfamily C (ABCC/MRP/CFTR). Journal of Human Genetics, 47:147-171, 2002

688. S. Higuchi, Y. Nakamura and S. Saito: Characterization of a VNTR polymorphism in the coding region of the CEL gene. Journal of Human Genetics, 47:213-215, 2002

689. Y.-M. Lin, Y. Furukawa, T. Tsunoda, C.-T. Yue, K.-C. Yang, and Y. Nakamura: Molecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas. Oncogene, 21:4120-4128, 2002

690. H. Iwasa, T. Itoh, R. Nagai, Y. Nakamura, T. Tanaka: Twenty single-nucleotide polymorphisms in four genes encording cardiac ion channels. Journal of Human Genetics, 47:208-212, 2002

691. T. Kayashima, M. Katahira, N. Harada, N. Miwa, T. Ohta, K. Yoshiura, N. Matsumoto, Y. Nakane, Y. Nakamura, T. Kajii, N. Niikawa, and T. Kishino: Maternal Isodisomy for 14q21-24 in a man with daiabetes mellitus. American Journal of Medical Genetics, 111:38-42, 2002

692. M. Nishiu, R. Yanagawa,S. Nakatsuka, M. Yao, T. Tsunoda, Y. Nakamura, and K. Aozasa: Microarray analysis of gene-expression profiles in diffuse large B-cell lymphoma: Identification of genes related to disease progression. Japanese Journal of Cancer Research, 93:894-901, 2002

693. A. Iida, S. Saito, A. Sekine, C. Mishima, Y. Kitamura, K. Kondo, S. Harigae, S. Osawa, and Y. Nakamura: Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. Journal of Human Genetics, 47:285-310, 2002

694. O. Kitahara, T. Katagiri, T. Tsunoda, Y. Harima, and Y. Nakamura: Classification of sensitivity or resistance of cervical cancers to ionizing radiation according to expression profiles of 62 genes selected by cDNA microarray analysis. Neoplasia, 4:295-303, 2002

695. R. Yagyu, R. Hamamoto, Y. Furukawa, H. Okabe, T. Yamamura, and Y. Nakamura: Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma. International Journal of Oncology, 20:1173-1178, 2002

696. A. Saito-Hisaminato, T. Katagiri, S. Kakiuchi, T. Nakamura, T. Tsunoda, and Y. Nakamura: Genome-wide profiling of gene expression in 29 normal human tissues with a cDNA microarray. DNA Research, 9:35-45, 2002

697. F. Saito-Ohara, Y. Fukuda, M. Ito, K.L. Agarwala, M. Hayashi, M. Matsuo, I. Imoto, K. Yamakawa,

Y. Nakamura, and J. Inazawa: The Xq22 inversion breakpoint interrupted a novl ras-like GTPase gene in a patient with Duchenne muscular dystrophy and profound mental reterdation. Am. J. Human Genetics, 71:637-645, 2002

698. S. Nagayama, T. Katagiri, T. Tsunoda, T. Hosaka, Y. Nakashima, N. Araki, K. Kusuzaki, T. Nakayama, T. Tsuboyama, T. Nakamura, M. Imamura, Y. Nakamura, and J. Toguchida: Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray. Cancer Research, 62:5859-5866, 2002

699. M. Takahashi, T. Tsunoda, M. Seiki, Y. Nakamura, and Y. Furukawa: Identification of membrane-type matrix metalloproteinase-1 as a target of the β-catenin/Tcf4 complex in human colorectal cancers. Oncogene, 21:5861-5867, 2002

700. S. Saito, A. Iida, A. Sekine, C. Ogawa, S. Kawauchi, S. Higuchi, M. Ohno, and Y. Nakamura: 906 variations among 27 genes encoding cytochrome P450 (CYP) enzymes and aldehyde dehydrogenases (ALDH) in the Japanese population. Journal of Human Genetics, 47:419-444, 2002

701. K. Inoue, K. Matsuda, M. Itoh, H. Tomoike, T. Aoyagi, R. Nagai, M. Hori, Y. Nakamura, and T. Tanaka: Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5. Human Molecular Genetics, 11:1775-1784, 2002

702. H. Ishiguro, T. Shimokawa, T. Tsunoda, T. Tanaka, Y. Fujii, Y. Nakamura and Y. Furukawa: Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas. Oncogene, 21:6387-6394, 2002

703. K. Yamazaki, M. Takazoe, T. Tanaka, T. Ichimori, and Y. Nakamura: Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's Disease. Journal of Human Genetics, 47:469-472, 2002

704. A. Iida, S. Saito, A. Sekine, C. Mishima, Y. Kitamura, K. Kondo, S. Harigae, S. Osawa, and Y. Nakamura: Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8. Journal of Human Genetics, 47:505-510, 2002

705. F. Akiyama, T. Tanaka, R. Yamada, Y. Ohnishi, T. Tsunoda, S. Maeda, T. Takei, W. Obara, K. Ito, K. Honda, K. Uchida, K. Tsuchiya, K. Nitta, K. Yumura, H. Nihei, T. Ujiie, Y. Nagane, Y. Suzuki, T. Fujioka, I. Narita, F. Gejyo, and Y. Nakamura: Single-nucleotide polymorphisms in the class II region of the major histocompatibility complex in Japanese patients with immunoglobulin A nephropathy. Journal of Human Genetics, 47:532-538, 2002

706. S. Saito, A. Iida, A. Sekine, C. Ogawa, S. Kawauchi, S. Higuchi, and Y. Nakamura: Catalog of 238 variations among six human genes encoding solute carriers (hSLCs) in the Japanese population. Journal of Human Genetics, 47:576-584, 2002

707. M. Takahashi, M. Fujita, Y. Furukawa, R. Hamamoto, T. Shimokawa, N. Miwa, and Y. Nakamura: Isolation of a novel human gene, APCDD1, as a direct target of the β-catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. Cancer Research, 62:5651-5656, 2002

708. Y. Yamanaka, Y. Hamazaki, Y. Sato, K. Ito, K. Watanabe, T. Heike, T. Nakahata and Y. Nakamura: Maturational sequence of neuroblastoma revealed by molecular analysis on cDNA microarrays. International Journal of Oncology, 21:803-807, 2002

709. Y. Kaneta, Y. Kagami, T. Katagiri, T. Tsunoda, I. Jin-nai, H. Taguchi, H. Hirai, K. Ohnishi, T. Ueda, N. Emi, A. Tomida, T. Tsuruo, Y. Nakamura, and R. Ohno: Prediction of sensitivity to STI571 among chronic myeloid leukemia patients by genome-wide cDNA microarray analysis. Japanese Journal of Cancer Research, 93:849-856, 2002

710. H. Haga, R. Yamada, Y. Ohnishi, Y. Nakamura, and T. Tanaka: Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190,562 genetic variations in the human genome. Journal of Human Genetics, 47:605-610, 2002

711. M. Horie, K. Kobayashi, S. Takeda, Y. Nakamura, G. E. Lyons, and T. Toda: Isolation and characterization of the mouse ortholog of the Fukuyama-type congenital musclular dystrophy gene. Genomics, 80:482-486, 2002

712. S. Hasegawa, Y. Furukawa, M. Li, S. Satoh, T. Kato, T. Watanabe, T. Katagiri, T. Tsunoda, Y. Yamaoka, and Y. Nakamura: Genome-wide analysis of gene expression in intestinal-type gastric cancers using a cDNA microarray representing 23,040 genes. Cancer Research, 62:7012-7017, 2002

713. K. Ozaki, Y. Ohnishi, A. Iida, A. Sekine, R. Yamada, T. Tsunoda, H. Sato, H. Sato, M. Hori, Y. Nakamura, and T. Tanaka: Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction. Nature Genetics, 32:650-654, 2002

714. J. Okutsu, T. Tsunoda, Y. Kaneta, T. Katagiri, O. Kitahara, H. Zembutsu, R. Yanagawa, S. Miyawaki, K. Kuriyama, N. Kubota, Y. Kimura, K. Kubo, F. Yagasaki, T. Higa, H.Taguchi, T. Tobita, H. Akiyama, A. Takeshita, Y.-H. Wang, T. Motoji, R. Ohno, and Y. Nakamura: Prediction of chemosensitivity for patients with acute myeloid leukemia, according to expression levels of 28 genes selected by genome-wide cDNA microarray analysis. Molecular Cancer Therapeutics, 1:1035-1042, 2002

715. S. Rokudai, N. Fujita, O. Kitahara, Y. Nakamura, and T. Tsuruo: Involvement of FKHR-dependent

TRADD expression in chemotherapeutic drug-induced apoptosis. Molecular and Cellular Biology, 22:8695-8708, 2002

716. H. Nishimori, Y. Sasaki, K. Yoshida, H. Irifune, H. Zenbutsu, T. Tanaka, T. Aoyama, T. Hosaka, S. Kawaguchi, T. Wada, J. Hata, J. Toguchida, Y. Nakamura, and T. Tokino: The Id2 gene is a novel target of the transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors. Oncogene, 21:8302-8309, 2002

717. S.Okuno, M. Kondo, Y. Yamasaki, H. Miyano, T. Ono, T. Iwanaga, K. Omori, M. Okano, M. Suzuki, H. Momota, H. Hishigaki, I. Hayashi, Y. Goto, H. Shinomiya, Y. Harada, T. Hirashima, N. Kanemoto, T. Asai, S. Wakitani, T. Takagi, Y. Nakamura, A. Tanigami, and K. Watanabe: Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF rats. Diabetes, Obesity, and Metabolism, 4:309-318, 2002

718. Y. Koshizuka, H. Kawaguchi, N. Ogata, T. Ikeda, A. Mabuchi, A. Seichi, Y. Nakamura. K. Nakamura. And S. Ikegawa: Nucleotide pyrophosphatase gene polymorphism associated with ossification of the posterior longitudinal ligament of the spine. Journal of Bone and Mineral Research, 17:138-144, 2002

719. S. Abe, T. Katagiri, A. Saito-Hisaminato, S. Usami, Y. Inoue, T. Tsunoda, and Y. Nakamura: Identification of CRYM as a candidate responsible for non-syndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues. Am. J. Human Genetics, 72:73-82, 2003

720. S. Tsukada, M. Iwai, J. Nishiu, M. Itoh, H. Tomoike, M. Horiuchi, Y. Nakamura, and T. Tanaka: Inhibition of experimental intimal thickening in mice lacking a novel G-protein-coupled receptor. Circulation, :313-319, 2003

721. S. Abe, K. Koyama, S. Usami, Y. Nakamura: Construction and characterization of a vestibular-specific cDNA library using T7-based RNA amplification. Journal of Human Genetics, 48:142-149, 2003

722. A. Iida, T. Tanaka, and Y. Nakamura: High-density SNP map of human ITR, a gene associated with vascular remodeling. Journal of Human Genetics, 48:170-172, 2003

723. A. Iida, and Y. Nakamura: High-resolution SNP map in the 55-kb region containing the selectin gene family on chromosome 1q24-q25. Journal of Human Genetics, 48:150-154, 2003

724. T. Kikuchi, Y. Daigo, T. Katagiri, T. Tsunoda, K. Okada, S. Kakiuchi, H. Zembutsu, Y. Furukawa, M. Kawamura, K. Kobayashi, K. Imai, and Y. Nakamura: Expression profiles of non-small cell lung cancers on cDNA microarrays: Identification of genes for prediction of lymph node metastasis and sensitivity to anti-cancer drugs. Oncogene, 22:2192-2205, 2003

725. T. Arimoto, T. Katagiri, K. Oda, T. Tsunoda, T. Yasugi, Y. Osuga, H. Yoshikawa, O. Nishii, T. Yano, Y. Taketani and Y. Nakamura: Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis. International Journal of Oncology, 22:551-560, 2003

726. A. Iida, S. Saito, A. Sekine, C. Mishima, Y. Kitamura, K. Kondo, S. Harigae, S. Osawa, and Y. Nakamura: Catalog of 668 SNPs detected among 31 genes encoding potential drug targets on the cell surface. Journal of Human Genetics, 48:23-46, 2003

727. M. Unoki, and Y. Nakamura: EGR2 induces apoptosis in various cancer-cell lines by direct transactivation of BNIP3L and BAK. Oncogene, 22:2172-2185, 2003

728. K. Ochi, A. Saito-Hisaminato, Y. Daigo, T. Katagiri, Y. Toyama, H. Matsumoto and Y. Nakamura: Expression profiles of two types of human knee-joint cartilage. Journal of Human Genetics, 48:177-182, 2003

729. C. Tanikawa, K. Matsuda, S. Fukuda, Y. Nakamura, and H. Arakawa: p53RDL1 regulates p53-dependent apoptosis. Nature Cell Biology, 5:216-223, 2003

730. G. Watanabe, H. Nishimori, H. Irifune, Y. Sasaki, S. Ishida, H. Zenbutsu, T. tanaka, S. Kawaguchi, T. Wada, J. hata, M. Kusakabe, K. Yoshida, Y. Nakamura, and T. Tokino: Induction of Tenascin-C by tumor-specific EWS-ETS fusion genes. Genes Chromosomes and Cancer, 36:224-232, 2003

731. M. Unoki, J. Okutsu, and Y. Nakamura: Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. International Journal of Oncology, 22:1217-1223, 2003

732. A. Yamada, T. Miyazaki, L-M. Lu, M. Ono, M. T. Ito, M. Terada, S. Mori, K. Hata, Y. Nozaki, S. Nakatsuru, Y. Nakamura, M. Onji, and M. Nose: Genetic basis of tissue specificity of vasculitis in MRL/lpr mics. Arthritis & Rheumatism, 48:1445-1451, 2003

733. S. Saito, A. Iida, A. Sekine, S. Kawagichi, S. Higuchi, C. Ogawa, and Y. Nakamura: Catalog of 680 variations among 8 cytochrome P450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. Journal of Human Genetics, 48:249-270, 2003

734. R. Ohno, and Y. Nakamura: Prediction of response to Imatinib by cDNA microarray analysis. Seminars in Hematology, 40:42-49, 2003

735. S. Kakiuchi, Y. Daigo, T. Tsunoda, S. Yano, S. Sone, and Y. Nakamura: Genome-wide analysis of organ-preferential metastasis of human small cell lung cancer in mice. Molecular Cancer Research, 1:485-499, 2003

736. H. Zembutsu, Y. Ohnishi, Y. Daigo, T. Katagiri, T. Kikuchi, S. Kakiuchi, K. Hirata and Y. Nakamura: Gene-Expression profiles of human tumor xenografts in nude mice treated orally with

the EGFR tyrosine kinase inhibitor ZD1839. International Journal of Oncology, 23:29-39, 2003 737. W. Obara, A. Iida, Y. Suzuki, T. Tanaka, F. Akiyama, S Maeda, Y Ohnishi, R. Yamada, A. Sekine,

T. Tsunoda, T. Takei, K. Ito, K. Honda, K. Uchida, K. Tsuchiya, W. Yumura, T. Ujiie, Y. Nagane, K. Nitta, S. Miyano, I. Narita, F. Gejyo, H. Nihei, T. Fujioka, and Y. Nakamura: Association of single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with Immunoglobulin A nephropathy (IgAN) in Japanese patients. Journal of Human Genetics, 48:293-299, 2003

738. H. Okabe, S. Satoh, Y. Furukawa, T. Kato, S. Hasegawa, Y. Nakajima, Y. Yamaoka, and Y. Nakamura: Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1. Cancer Research, 63:3043-3048, 2003

739. S. Takeda, M. Kondo, J.Sasaki, H. Kurahashi, H. Kano, K. Arai, K. Misaki, T. Fukui, K. Kobayashi, M. Tachikawa, M. Imamura, Y. Nakamura, T. Shimizu, T. Murakami, Y. Sunada. T. Fujikado, K. Matsumura, T. Terashima and T. Toda: Fukutin is required for maintenance of muscle integrity, cortical histiogenesis and normal eye development. Human Molecular Genetics, 12:1449-1459, 2003

740. C.-C. Ng, H. Arakawa, S. Fukuda, H. Kondoh, and Y. Nakamura: p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1. Oncogene, 22:4449-4458, 2003

741. T. Kimura, M. Gotoh, Y. Nakamura and H. Arakawa: hCDC4b, a regulator of Cyclin E, as a direct transcriptional target of p53. Cancer Science, 94:431-436, 2003

742. Y. Kaneta, Y. Kagami, T. Tsunoda, R. Ohno, Y. Nakamura, and T. Katagiri: Genome-wide analysis of gene-expression profiles in chronic myeloid leukemia cells using a cDNA microarray. International Journal of Oncology, 23:681-691, 2003

743. A. Iida, and Y. Nakamura: Japanese Efforts in Pharmacogenomics. Current Pharmacogenomics, 1:203-215, 2003

744. K. Okada, T. Katagiri, T. Tsunoda, Y. Mizutani, Y. Suzuki, M. Kamada, T. Fujioka, T. Shuin, T. Miki, and Y. Nakamura: Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray. International Journal of Oncology, 23:1615-1635, 2003

745. K. Ueda, H. Arakawa and Y. Nakamura: Dual-Specificity Phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53. Oncogene, 22:5586-5591, 2003

746. T. Nakatsura, Y. Yoshitake, S. Senju, M. Monji, H. Komori, Y. Motomura, S. Hosaka, T. Beppu, T. Ishiko, H. Kamohara, H. Ashihara, T. Katagiri, Y. Furukawa, S. Fujiyama, M. Ogawa, Y. Nakamura, and Y. Nishimura: Glypican-3, over-expressed specifically in human hepatocellular carcinoma, is a novel tumor marker. Biochemical and Biophysical Research Communications, 306:16-25, 2003

747. A. Iida, K. Ozaki, Y. Ohnishi, T. Tanaka and Y. Nakamura: Identification of 46 novel SNPs in the 130-kb region containing a myocardial infarction susceptibility gene on chromosomal band 6p21. Journal of Human Genetics, 48:476-479, 2003

748. T. Shimokawa, Y. Furukawa, M. Sakai, M. Li, N. Miwa, Y.-M. Lin and Y. Nakamura: Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the β-catenin/T-cell factor complex. Cancer Research, 63:6116-6120, 2003

749. A. Suzuki, R. Yamada, X. Chang, S.Tokuhiro, T. Sawada, M. Suzuki, M. Nagasaki, M. Nakayama-Hamada, R.Kawaida, M. Ono, M. Ohtsuki, H. Furukawa, S. Yoshino, M. Yukioka, S. Touma, T. Matsubara, S. Wakitani, R. Teshima, A. Sekine, A.Iida, A. Takahashi, T. Tsunoda, Y. Nakamura, and K. Yamamoto: Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nature Genetics, 34:395-402, 2003

750. T. Kimura, S. Takeda, Y. Sagiya, M. Gotoh, Y. Nakamura and H. Arakawa: Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools. Nature Genetics, 34:440-445, 2003

751. S. Saito, A. Iida, A. Sekine, S. Kawauchi, S. Higuchi, C. Ogawa, and Y. Nakamura: Catalog of 178 variations in the Japanese population among eight human genes encoding G protein-coupled receptors (GPCRs). Journal of Human Genetics, 48:461-468, 2003

752. N. Tanaka, T. Babazono, S. Saito, A. Sekine, T. Tsunoda, M. Haneda, Y. Tanaka, T. Fujioka, K. Kaku, R. Kawamori, R. Kikkawa, Y. Iwamoto, Y. Nakamura and S. Maeda: Associationof solute carrier family 12 (sodium/chloride) member 3 with diabetic nephropathy, identified by genome-wide analyses of Single Nucleotide Polymorphisms. Diabetes, 52:2848-2853, 2003

753. C. Suzuki, Y. Daigo, T. Kikuchi, T. Katagiri and Y. Nakamura: Identification of COX17 as a therapeutic target for non-small cell lung cancer. Cancer Research, 63:7038-7041, 2003

754. S. Abe, S. Usami, and Y. Nakamura: Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss. Journal of Human Genetics, 48:564-570, 2003

755. M. Unoki, and Y. Nakamura: Methylation at CpG islands in intron1 of EGR2 confers enhancer-like activity. FEBS letters, 554:67-72, 2003

756. S. Tokuhiro, R. Yamada, X. Chang, A. Suzuki, Y. Kochi, T. Sawada, M. Suzuki, M. Nagasaki, M. Ohtsuki, M. Ono, H. Furukawa, M. Nagashima, S. Yoshino, A. Mabuchi, A. Sekine, S. Saito, A. Takahashi, T. Tsunoda, Y. Nakamura and K. Yamamoto: An intronic SNP in a RUNX1 binding

site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nature Genetics, 35:341-348, 2003

757. The International HapMap Consortium: The International HapMap Project. Nature, 426:789-796, 2003

758. Y. Koshizuka, T. Yamada, K. Hoshi, T. Ogasawara, U. Chung, H. Kawano, Y. Nakamura, K. Nakamura, S. Ikegawa, H. Kawaguchi: Cystatin 10, a novel chondrocyte-specific protein, may promote the last steps of the chondrocyte differentiation pathway. Journal of Biological Chemistry, 278:48259-48266, 2003

759. S. Dan, M. Shirakawa, Y. Mukai, Y. Yoshida, K. Yamazaki, T. Kawaguchi, M. Matsuura, Y. Nakamura, and T. Yamori: Identification of Candidate predictive markers of anticancer drug sensitivity using a panel of human cancer cell lines. Cancer Science, 94:1074-1082, 2003

760. Y. Sasaki, H. Mita, M. Toyota, S. Ishida, I. Morimoto, T. Yamashita, T. Tanaka, K. Imai, Y. Nakamura, and T. Tokino: Identification of the interleukin 4 receptor α gene as a direct target for p73. Cancer Research, 63:8145-8152, 2003

761. H. Peeters, P. Debeer, A. Bairoch, V. Wilquet, C. Huysmans, E. Parthoens, J.P. Fryns, M. Gewillig, Y. Nakamura, N. Niikawa, W. Van de Ven, and K. Devriendt: PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. Human Genetics, 112:573-580, 2003

762. H. Okabe, Y. Furukawa, T. Kato, S. Hasegawa, Y. Yamaoka, and Y. Nakamura: Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas. International Journal of Oncology, 24:43-48, 2004

763. Y. Anazawa, H.Arakawa, H. Nakagawa, and Y. Nakamura: Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway. Oncogene, 23:7621-7627, 2004

764. K. Yoshida, M. Monden, Y. Nakamura and H. Arakawa: Adenovirus-mediated p53AIP1 gene transfer as a new strategy for treatment of p53-resistant tumors. Cancer Science, 95:91-97, 2004

765. M. Li, Y.-M. Lin, S. Hasegawa, T. Shimokawa, K. Murata, M. Kameyama, O. Ishikawa, T. Katagiri, T. Tsunoda, Y. Nakamura and Y. Furukawa: Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray. International Journal of Oncology, 24:305-312, 2004

766. S. Nagayama, M. Iiizumi, T. Katagiri, J. Toguchida and Y. Nakamura: Identification of PDZK4, a novel human gene with PDZ domains, that is up-regulated in synovial sarcomas. Oncogene, 23:5551-5557, 2004

767. K. Ochi, Y. Daigo, T. Katagiri, S. Nagayama, T. Tsunoda, A. Myoui, N. Naka, N. Araki, I. Kudawara, M. Ieguchi, Y. Toyama, J. Toguchida, H. Yoshikawa and Y. Nakamura: Prediction of response to neoadjuvant chemotherapy for osteosarcoma by gene-expression profiles. International Journal of Oncology, 24:647-655, 2004

768. Y. Nakamura: Isolation of p53-target genes and their functional analysis (review). Cancer Science, 95:7-11, 2004

769. T. Sekiya, S. Adachi, K. Kohu, T. Yamada, O. Higuchi, Y. Furukawa, Y. Nakamura, T. Nakamura, K. Tashiro, S. Kuhara, S. Ohwada, and T. Akiyama: Identification of BAP, an inhibitor of TGF-β signaling, as a target of the β-catenin pathway in colorectal tumor cells. Journal of Biological Chemistry, 279:6840-6846, 2004

770. M. Doi, A. Nagano, and Y. Nakamura: Molecular cloning and characterization of a novel gene, EMILIN-5, and its possible Involvement in skeletal development. Biochemical and Biophysical Research Communications, 313:888-893, 2004

771. K. Yoon, Y. Nakamura and H. Arakawa: Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses. Journal of Human Genetics, 49:134-140, 2004

772. T. Nakamura, Y. Furukawa, T. Tsunoda, H. Ohigashi, K. Murata, O. Ishikawa, K. Ohgaki, N. Kashimura, M. Miyamoto, S. Hirano, S. Kondo, H. Katoh, and Y. Nakamura, and T. Katagiri: Genome-wide cDNA microarray analysis of gene-expression profiles in pancreatic cancers Using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection. Oncogene, 23:2385-2400, 2004

773. T. Ota, Y. Suzuki, T. Nishikawa, T. Otsuki, T. Sugiyama, R. Irie, A. Wakamatsu, K. Hayashi, H. Sato, K. Nagai, K. Kimura, H. Makita, M. Sekine, M. Obayashi, T. Nishi, T. Shibahara, T. Tanaka, S. Ishii, J. Yamamoto, K. Saito, Y. Kawai, Y. Isono, Y. Nakamura, K. Nagahari, K. Murakami, T. Yasuda, T. Iwayanagi, M. Wagatsuma, A. Shiratori, H. Sudo, T. Hosoiri, Y. Kaku, H. Kodaira, H. Kondo, M. Sugawara, M. Takahashi, K. Kanda, T. Yokoi, T. Furuya, E. Kikkawa, Y. Omura, K. Abe, K. Kamihara, N. Katsuta, K. Sato, M. Tanikawa, M. Yamazaki, K. Ninomiya, T. Ishibashi, H. Yamashita, K. Murakawa, K. Fujimori, H. Tanai, M. Kimata, M. Watanabe, S. Hiraoka, Y. Chiba, S. Ishida, Y. Ono, S. Takiguchi, S. Watanabe, M. Yosida, T. Hotuta, J. Kusano, K. Kanehori, A. Takahashi-Fujii, H. Hara, T. Tanase, Y. Nomura, S. Togiya, F. Komai, R. Hara, K. Takeuchi, M. Arita, N. Imose, K. Musashino, H. Yuuki, A. Oshima, N. Sasaki, S. Aotsuka, Y. Yoshikawa, H. Matsunawa, T. Ichihara, N. Shiohata, S. Sano, S. Moriya, H. Momiyama, N. Satoh, S. Takami, Y. Terashima, O. Suzuki, S. Nakagawa, A. Senoh, H. Mizoguchi, Y. Goto, F. Shimizu, H. Wakebe, H. Hishigaki, T. Watanabe, A. Sugiyama, M. Takemoto, B. Kawakami, M. Yamazaki, K. Watanabe, A. Kumagai, S. Itakura, Y. Fukuzumi, Y. Fujimori, M. Komiyama, H. Tashiro, A. Tanigami, T.

Fujiwara, T. Ono, K. Yamada, Y. Fujii, K. Ozaki, M. Hirao, Y. Ohmori, A. Kawabata, T. Hikiji, N. Kobatake, H. Inagaki, Y. Ikema, S. Okamoto, R. Okitani, T. Kawakami, S. Noguchi, T. Itoh, K. Shigeta, T. Senba, K. Matsumura, Y. Nakajima, T. Mizuno, M. Morinaga, M. Sasaki, T. Togashi, M. Oyama, H. Hata, M. Watanabe, T. Komatsu, J. Mizushima-Sugano, T. Satoh, Y. Shirai, Y. Takahashi, K. Nakagawa, K. Okumura, T. Nagase, N. Nomura, H. Kikuchi, Y. Masuho, R. Yamashita, K. Nakai, T. Yada, Y. Nakamura, O. Ohara, T. Isogai and S. Sugano: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature Genetics, 36:40-45, 2004

774. A. Iida, S. Saito, A. Sekine, Y. Kataoka, W. Tabei, and Y. Nakamura: Catalog of 300 SNPs in 23 genes encoding G-protein coupled receptors. Journal of Human Genetics, 49:194-208, 2004

775. Y. Kochi, R. Yamada, K. Kobayashi, A. Takahashi, A. Suzuki, A. Sekine, A. Mabuchi, F. Akiyama, T. Tsunoda, Y. Nakamura, and K. Yamamoto: Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences. Arthritis & Rheumatism, 50:63-71, 2004

776. Y. Harima, A. Togashi, K. Horikoshi, M. Imamura, M. Sougawa, S. Sawada, T. Tsunoda, Y. Nakamura, and T. Katagiri: Prediction of outcome of advanced cervical cancer to thermoradiotherapy according to expression profiles of 35 genes selected by cDNA microarray analysis. Int. J. of Radiation Oncology, Biology, Physics, 60:237-248, 2004

777. D. Yuki, Y.-M. Lin, Y. Fujii, Y. Nakamura, and Y. Furukawa: Isolation of LEMD domain containing 1, a novel testis-specific gene expressed in colorectal cancer. Oncology Reports, 12:275-280, 2004

778. N. Jinawath, Y. Furukawa, and Y. Nakamura: Identification of NOL8,a nucleolar protein containing an RNA recognition motif (RRM),which was overexpressed in diffuse-type gastric cancer. Cancer Science, 95:430-435, 2004

779. A. Iida, Y. Nakamura: Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13. Journal of Human Genetics, 49:387-390, 2004

780. K. Ozaki, K. Inoue, H. Sato, A. Iida, Y. Ohnishi, A. Sekine, H. Sato, K. Odashiro, M. Nobuyoshi, M. Hori, Y. Nakamura, and T. Tanaka: Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-α secretion in vitro. Nature, 429:72-75, 2004

781. N. Kamatani, A. Sekine, T. Kitamoto, A. Iida, S. Saito, A. Kogame, E. Inoue, M. Kawamoto, M. Harigai, and Y. Nakamura: Large-scale single-nucleotide polymorphism (SNP) and haplotype analyses, using dense SNP maps, of 199 drug-related genes in 752 subjects: The analysis of the association between uncommon SNPs within haplotype blocks and the haplotypes constructed with haplotype-tagging SNPs. Am. J. Human Genetics, 75:190-203, 2004

782. A. Iida, S. Saito, A. Sekine, W. Tabei, Y. Kataoka, and Y. Nakamura: Identification of 20 novel SNPs in the guanine nucleotide binding protein alpha 12 gene locus. Journal of Human Genetics, 49:445-448, 2004

783. N. Jinawath, Y. Furukawa, S. Hasegawa, M. Li, T. Tsunoda, S.Satoh, T. Yamaguchi, H. Imamura, M.Inoue, H. Shiozaki, and Y. Nakamura: Comparison of gene-expression profiles between diffuse-and intestinal-type gastric cancers using a genome-wide cDNA microarray. Oncogene, 23:6830-6844, 2004

784. T. Tsunoda, G. M. Lathrop, A. Sekine, R. Yamada, A. Takahashi, Y. Ohnishi, T. Tanaka and Y. Nakamura: Variation of gene-based SNPs and linkage disequilibrium patterns in the human genome. Human Molecular Genetics, 13:1623-1632, 2004

785. R. Hamamoto, Y. Furukawa, M. Morita, Y. Iimura, F. P. Silva, M. Li, R. Yagyu and Y. Nakamura: SMYD3 encodes a novel histone methyltransferase involved in the proliferation of cancer cells. Nature Cell Biology, 6:731-740, 2004

786. S. Ashida, H. Nakagawa, T. Katagiri, M. Furihata, M.Iiizumi, Y. Anazawa, T. Tsunoda, R. Takata, K. Kasahara, T. Miki, T. Fujioka, T. Shuin, and Y. Nakamura: Molecular Features of the Transition from Prostatic Intraepithelial Neoplasia (PIN) to Prostate Cancer: Genome-wide Gene-expression profiles of Prostate Cancers and PINs. Cancer Research, 64:5963-5972, 2004

787. T. Nishidate, T. Katagiri, M.-L Lin, Y. Mano, Y. Miki, F. Kasumi, M. Yoshimoto, T. Tsunoda, K. Hirata, and Y. Nakamura: Genome-wide gene expression profiles of breast-cancer cells purified with laser microbeam microdissection: Identification of genes associated with progression and metastasis. International Journal of Oncology, 25:797-819, 2004

788. T. Mizuguchi, G. Collod-Beroud, T. Akiyama, M. Abifadel, N. Harada, T. Morisaki, D. Allard, M. Varret, M. Claustres, H. Morisaki, M. Ihara, A. Kinoshita, K. Yoshiura, C. Junien, T. Kajii, G. Jondeau, T. Ohta, T. Kishino, Y. Furukawa, Y. Nakamura, N. Niikawa, C. Boileau, and N. Matsumoto: Heterozygous TGFBR2 mutations in Marfan syndrome. Nature Genetics, 36:855-860, 2004

789. M. Unoki, T. Nishidate, and Y. Nakamura: ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. Oncogene, 23:7601-7610, 2004

790. P.-C. Cha, R. Yamada, A. Sekine, Y. Nakamura, C.-L. Koha: Inference from the relationships between linkage disequilibrium and allele frequency distributions of 240 candidate SNPs in 109

genes of drug-related genes in 4 Asian populations. Journal of Human Genetics, 49:558-572, 2004

791. M. Takahashi, Y.-M. Lin, Y. Nakamura, and Y. Furukawa: Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer. Oncogene, 23:9289-9294, 2004

792. Y. Yoshitake, T. Nakatsura, M. Monji, S. Senju, H. Matsuyoshi, H. Tsukamoto, S. Hosaka, H. Komori, D. Fukuma, Y. Ikuta, T. Katagiri, Y. Furukawa, H. Ito, M. Shinohara, Y. Nakamura, and Y. Nishimura: Proliferation potential-related protein, an ideal esophageal cancer antigen for immnotherapy, identified using complementary DNA microarray analysis. Clinical Cancer Research, 10:6437-6448, 2004

793. R. Yagyu, Y. Furukawa, Y.-M. Lin, T. Shimokawa, T. Yamamura, and Y. Nakamura: A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer. International Journal of Oncology, 25:1343-1348, 2004

794. M. Nishiu, Y. Tomita, S. Nakatsuka, T. Takakuwa, N. Iizuka, Y. Hoshida, J. Ikeda, K. Iuchi, R. Yanagawa, Y. Nakamura and K. Aozasa: Distinct pattern of gene expression in pyothorax-associated lymphoma(PAL),a lymphoma developing inlong-standing inflammation. Cancer Science, 95:828-834, 2004

795. N. Ishikawa, Y. Daigo, W. Yasui, K. Inai, H. Nishimura, E. Tsuchiya, N. Kohno, and Y. Nakamura: ADAM8 as a novel serological and histochemical marker for lung cancer. Clinical Cancer Research, 10:8363-8370, 2004

796. K. Okada, E. Hirota, Y. Mizutani, T. Fujioka, T. Shuin, T. Miki, Y. Nakamura and T. Katagiri: Oncogenic role of NALP7 in testicular seminomas. Cancer Science, 95:949-954, 2004

797. K. Yamazaki, M. Takazoe, T. Tanaka, T. Ichimori, S. Saito, A. Iida, Y. Onouchi, A. Hata and Y. Nakamura: Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease. Journal of Human Genetics, 49:664-668, 2004

798. T. Minaguchi, H. Yoshikawa, S. Nakagawa, T. Yasugi, T. Yano, H. Iwase, K. Mizutani, K. Shiromizu, K. Ohmi, Y. Watanabe, K. noda, M. Nishiu, Y. Nakamura, Y. Taketani: Association of PTEN mutation with HPV-negative adenocarcinoma of the uterine cervix. Cancer Letters, 210:57-62, 2004

799. T.Nakatsura, H. Komori, T. Kudo, Y. Yoshitake, S. Senju, T. Katagiri, Y. Furukawa, M. Ogawa, Y. Nakamura and Y. Nishimura: Mouse homologue of a novel human oncofetal antigen, Glypican-3, evokes T- cell-mediated tumor rejection without autoimmune reactions in mice. Clinical Cancer Research, 10:8630-8640, 2004

800. N. Uchida, T. Tsunoda, S. Wada, Y. Furukawa, Y. Nakamura, H. Tahara: Ring finger protein 43 as a new target for cancer immunotherapy. Clinical Cancer Research, 10:8577-8586, 2004

801. S. Kakiuchi, Y. Daigo, N. Ishikawa, C. Furukawa, T. Tsunoda, S. Yano, K. Nakagawa, T. Tsuruo, N. Kohno, M. Fukuoka, S. Sone, and Y. Nakamura: Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib （ Iressa,ZD1839). Human Molecular Genetics, 13:3029-3043, 2004

802. H. Kamiyama, K. Kurosaki, M. Kurimoto, T. Katagiri, Y. Nakamura, M. Kurokawa, H. Sato, S. Endo and K. Shiraki: Herpes simplex virus induced death receptor-dependent apoptosis and regression of transplanted human cancers. Cancer Science, 95:990-998, 2004

803. Y. Onouchi, S. Onoue, M. Tamari, K. Wakui, Y. Fukushima, M. Yashiro, Y. Nakamura, H. Yanagawa, F. Kishi, K. Ouchi, M. Terai, K. Hamamoto, F. Kudo, H. Aotsuka, Y. Sato, A. Nariai, Y. Kaburagi, M. Miura, T. Saji, T. Kawasaki, Y. Nakamura, and A. Hata: CD40 ligand gene and Kawasaki disease. Eur. J. Human Genetics, 12:1062-1068, 2004

804. T. Hirota, K. Obara, A. Matsuda, M. Akahoshi, K. Nakashima, K. Hasegawa, N. Takahashi, M. Shimizu, H. Sekiguchi, M. Kokubo, S. Doi, H. Fujiwara, A. Miyatake, K. Fujita, T. Enomoto, F. Kishi, Y. Suzuki, H. Saito, Y. Nakamura, T. Shirakawa, and M. Tamari: Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma. Journal of Human Genetics, 49:370-375, 2004

805. A. Kanazawa, S. Tsukada, A. Sekine, T. Tsunoda, A. Takahashi, A. Kashiwagi, Y. Tanaka, T. Babazono, M. Matsuda, K. Kaku, Y. Iwamoto, R. Kawamori, R. Kikkawa, Y. Nakamura, and S. Maeda; Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes. Am. J. Human Genetics, 75:832-843, 2004

806. M. Onda, M. Emi, H. Nagai, T. Nagahata, K. Tsumagari, T. Fujimoto, F. Akiyama, G. Sakamoto, M. Makita, F. Kasumi, Y. Miki, T. Tanaka, T. Tsunoda, and Y. Nakamura: Gene expression patterns as marker for 5-year postoperative prognosis of primary breast cancers. J Cancer Res Clin Oncol,, 130:537-545, 2004

807. P. Graff, J. Seim, O. Amellem, H. Arakawa, Y. Nakamura, K. K. Andersson, T. Stokke and E. O. Pettersen: pRb protection by RNR counteraction of pRb-dependent protection after extreme hypoxia by elevated ribonucleotide reductase. Cell Prolif., 37:367-383, 2004

808. A. Niida, T. Hiroko, M. Kasai, Y. Furukawa, Y. Nakamura, Y. Suzuki, S. Sugano and T. Akiyama: DKK1, a negative regulator of Wnt signaling, is a target of the b-catenin/TCF pathway. Oncogene, 23:8520-8526, 2004

809. S. Ohtsubo, A. Iida, K. Nitta, T. Tanaka, R. Yamada, Y. Ohnishi, S. Maeda, T. Tsunoda, T. Takei,

W. Obara, F. Akiyama, K. Ito, K. Honda, K. Uchida, K. Tsuchiya, W. Yumura, T. Ujiie, Y. Nagane, S. Miyano, Y. Suzuki, I. Narita, F. Gejyo, T. Fujioka, H. Nihei and Y. Nakamura: Association of a single-nucleotide polymorphism in the immunoglobulin u-binding protein 2 gene with immunoglobulin A nephropathy. Journal of Human Genetics, 50:30-35, 2005

810. F. P. Silva, R. Hamamoto, Y. Nakamura, and Y. Furukawa: WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation. Neoplasia, 7:348-355, 2005

811. A. Iida, K. Ozaki, T. Tanaka, and Y. Nakamura: Fine-scale SNP map of an 11-kb genomic region at 22q13.1 containing the galectin-1 gene. Journal of Human Genetics, 50:42-45, 2005

812. W.-R. Park, Y. Nakamura: a novel p53-inducible gene involved in the p53-dependent cell-survival pathway. Cancer Research, 65:1197-1206, 2005

813. K. Taniuchi, H. Nakagawa, M.Hosokawa, T. Nakamura, H. Eguchi, H. Ohigashi, O. Ishikawa, T. Katagiri, and Y. Nakamura: Overexpressed P-cadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating Rho-family GTPases. Cancer Research, 65:3092-3099, 2005

814. R. Takata, T. Katagiri, M. Kanehira, T. Tsunoda, T. Shuin, T. Miki, M. Namiki, K. Kohri, Y. Matsushita, T. Fujioka and Y. Nakamura: Predicting response to methotrexate, vinblastine, doxorubicin, and cisplatin neoadjuvant chemotherapy for bladder cancers through genome-wide gene expression profiling. Clinical Cancer Research, 11:2625-2636, 2005

815. H. Kizawa, I. Kou, A. Iida, A. Sudo, Y. Miyamoto, A. Fukuda, A. Mabuchi, A. Kotani, A. Kawakami, S. Yamamoto, N. Uchida, K. Nakamura, K. Notoya, Y. Nakamura and S. Ikegawa: An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nature Genetics, 37:138-144, 2005

816. L. Yang, A. C. C. Leung, J. M. Y. Ko, P. H. Y. Lo, J. C. O. Tang, G. Srivastava, M. Oshimura, E. J. Stanbridge, Y. Daigo, Y. Nakamura, C. M. C. Tang, K. W. Lau, S. Law and M. L. Lung: Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma. Oncogene, 24:697-705, 2005

817. K.Taniuchi, H. Nakagawa, T. Nakamura, H. Eguchi, H. Ohigashi, O. Ishikawa, T. Katagiri, and Y. Nakamura: Down-regulation of RAB6KIFL / KIF20A, a kinesin involved with membrane trafficking of discs large homolog 5, can attenuate growth of pancreatic cancer cells. Cancer Research, 65:105-112, 2005

818. A. Iida, Y. Nakamura: Identification of 156 novel SNPs in 29 genes encoding G-protein coupled receptors. Journal of Human Genetics, 50:182-191, 2005

819. Y. Anazawa, H. Nakagawa, M. Furihara, S. Ashida, K. Tamura, H. Yoshioka, T. Shuin, T. Fujioka, T. Katagiri, and Y. Nakamura: PCOTH, a novel gene over-expressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ib/SET. Cancer Research, 65:4578-4586, 2005

820. A. Togashi, T. Katagiri, S. Ashida, T. Fujioka, O. Maruyama, Y. Wakumoto, Y. Sakamoto, M. Fujime, Y. Kawachi, T. Shuin and Y. Nakamura: Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy. Cancer Research, 65:4817-4826, 2005

821. S. Nagayama, C. Fukukawa, T. Katagiri, T. Okamoto, T. Aoyama, N. Oyaizu, M. Imamura, J. Toguchida and Y. Nakamura: Therapeutic potential of antibodies against FZD10, a cell-surface protein, for synovial sarcomas. Oncogene, 24:6201-6212, 2005

822. H. Mototani, A. Manuchi, S. Saito, M. Fujioka, A. Iida, Y. Takatori, A. Kotani, T. Kubo, K. Nakamura, A. Sekine, Y. Murakami, T. Tsunoda, K. Notoya, Y. Nakamura and S. Ikegawa: A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese. Human Molecular Genetics, 14:1009-1017, 2005

823. K. Obama, K. Ura, M. Li, T. Katagiri, T. Tsunoda, A. Nomura, S. Satoh, Y. Nakamura, and Y. Furukawa: Genome-wide analysis of gene expression in human intrahepatic cholangiocarcinomas. Hepatology, 41:1339-1348, 2005

824. K. Obama, K. Ura, S. Satoh, Y. Nakamura, and Y. Furukawa: Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma. Oncology Reports, 14:701-706, 2005

825. T. Watanabe, T. Suda, T. Tsunoda, N. Uchida, K. Ura, T. Kato, S. Hasegawa, S. Satoh, S. Ohgi, H. Tahara, Y. Furukawa and Y. Nakamura: Identification of Immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. Cancer Science, 96:498-506, 2005

826. S. Maeda, S. Tsukada, A. Kanazawa, A. Sekine, T. Tsunoda, D. Koya, H. Maegawa, A. Kashiwagi, T. Babazono, M. Matsuda, Y. Tanaka, T. Fujioka, H. Hirose, T. Eguchi, Y. Ohno, C. Groves, A. Hattersley, G. Hitman, M. Walker, K. Kaku, Y. Iwamoto, R. Kawamori, R. Kikkawa, N. Kamatani, M. McCarthy, and Y. Nakamura: Genetic Variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. Journal of Human Genetics, 50:283-292, 2005

827. S.Shimazaki, Y. Kawamura, A. Kanazawa, A. Sekine, S. Saito, T. Tsunoda, D. Koya, T. Babazono, Y. Tanaka, M. Matsuda, K. Kawai, T. Iiizumi, M. Imanishi, T. Shinosaki, T. Yanagimoto, M. Ikeda, S. Omachi, A. Kashiwagi, K. Kaku, Y. Iwamoto, R. Kawamori, R. Kikkawa, M. Nakajima,

Y. Nakamura, and S. Maeda: Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy. Diabetes, 54:1171-1178, 2005

828. M. Akahoshi, K. Obara, T. Hirota, A. Matsuda, K. Hasegawa, N. Takahashi, M. Shimizu, K. Nakashima, L. Cheng, S. Doi, H. Fujiwara, A. Miyatake, K. Fujita, N. Higashi, M. Taniguchi, T. Enomoto, X.Q. Mao, H. Nakashima, C.N. Adra, Y. Nakamura, M. Tamari, and T. Shirakawa : Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. Human Genetics, 117:16-26, 2005

829. T. Kato, Y. Daigo, S. Hayama, N. Ishikawa, T. Yamabuki, T. Ito, M. Miyamoto, S. Kondo and Y. Nakamura: A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. Cancer Research, 65:5638-5646, 2005

830. K. Asamura, S. Abe, Y. Imamura, A. Aszodi, N. Suzuki, S. Hashimoto, Y. Takumi, T. Hayashi, R. Fassler, Y. Nakamura, and S. Usami: Type IX collagen is crucial for normal hearing. Neuroscience, 132:493-500, 2005

831. R. Kawaida, R. Yamada, K. Kobayashi, S. Tokuhiro, A. Suzuki, Y Kochi, X. Chang, A. Sekine, T. Tsunoda, T. Sawada, H. Furukawa, Y. Nakamura, and K. Yamamoto: CUL1, a component of E3 ubiquitin ligase, alters lymphocyte signal transduction with possible effect on rheumatoid arthritis. Genes Immun, 6:194-202, 2005

832. S. Seki, Y. Kawaguchi, K. Chiba, Y. Mikami, H. Kizawa, T. Oya, F. Mio, M. Mori, Y. Miyamoto, I. Masuda, T. Tsunoda, M. Kamata, T. Kubo, Y. Toyama, T. Kimura, Y. Nakamura and S. Ikegawa: A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Nature Genetics, 37:607-612, 2005

833. Y. Kochi, R. Yamada, A. Suzuki, J. B. Harley, S. Shirasawa, T. Sawada, S. C. Bae, S. Tokuhiro, X. Chang, A. Sekine, A. Takahashi, T. Tsunoda, Y. Ohnishi, K. M. Kaufman, C. P. Kang, C. Kang, S. Otsubo, W. Yumura, A. Mimori, T. Koike, Y. Nakamura, T. Sasazuki and K. Yamamoto: A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nature Genetics, 37:478-485, 2005

834. C. Furukawa, Y. Daigo, N. Ishikawa, T. Kato, T. Ito, E. Tsuchiya, S. Sone, and Y. Nakamura: Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer. Cancer Research, 65:7102-7110, 2005

835. M. Tsuge, R. Hamamoto, F. P. Silva, Y. Ohnishi, K. Chayama, N. Kamatani, Y. Furukawa, and Y. Nakamura: A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers. Nature Genetics, 37:1104-1107, 2005

836. M. Takahashi, Y. Nakamura, K. Obama, and Y. Furukawa: Identification of SP5 as a downstream gene of the β-catenin/Tcf pathway and its enhanced expression in human colon cancer. International Journal of Oncology, 27:1483-1487, 2005

837. N. Ishikawa, Y. Daigo, A. Takano, M. Taniwaki, T. Kato, S. Hayama, H. Murakami, Y. Takeshima, K. Inai, H. Nishimura, E. Tsuchiya, N. Kohno, and Y. Nakamura: Increases of amphiregulin and transforming growth factor-α in serum as predictors of poor response to Gefitinib among patients with advanced non-small cell lung cancers. Cancer Research, 65:9176-9184, 2005

838. C. Suzuki, Y. Daigo, N. Ishikawa, T. Kato, S. Hayama, T. Ito, E. Tsuchiya, and Y. Nakamura: ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway. Cancer Research, 65:11314-11325, 2005

839. K. Asamura, S. Abe, H. Fukuoka, Y. Nakamura, and S. Usami: Mutation analysis of COL9A3, a gene highly expressed in the cochlea, in hearing loss patients. Auris Nasus Larynx, 32:113-117, 2005

840. A. Kanazawa, Y. Kawamura, A. Sekine,A. Iida,T. Tsunoda,A. Kashiwagi,Y. Tanaka,T. Babazono,M. Matsuda,K. Kawai,T. Iiizumi,T. Fujioka,M. Imanishi,K. Kaku,Y. Iwamoto,R. Kawamori,R. Kikkawa,Y. Nakamura, and S.Maeda: Single nucleotide polymorphosms in the gene encoding Kruppel-like factor 7 are associated with type 2diabetes. Diabetologia, 48:1315-1322, 2005

841. C. Fukukawa, Y. Nakamura and T. Katagiri: Molecular target therapy for synovial sarcoma. Future Oncology, 1:805-812, 2005

842. T. Watanabe, M. Suzuki,Y. Yamasaki,S. Okuno,H. Hishigaki,T. Ono,K. Oga,A. Mizoguchi-Miyakita,A. Tsuji,N. Kanemoto,S. Wakitani,T. Takagi,Y. Nakamura, and A. Tanigami: Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmol in the OLETD rat. Clinical and Experimental Pharmacology and Physiology, 32:355-366, 2005

843. K. Yamazaki, D. McGovern, J. Ragoussis, M. Paolucci, H. Butler, D. Jewell, L. Cardon, M. Takazoe, T. Tanaka, T. Ichimori, S. Saito, A. Sekine, A. Iida, A. Takahashi, T. Tsunoda, M. Lathrop and Y. Nakamura: Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Human Molecular Genetics, 14:3499-3506, 2005

844. The International HapMap Consortium: A haplotype map of the human genome. Nature, 437:1299-1320, 2005

845. T. Ishibe, T. Nakayama, T. Okamoto, T. Aoyama, K. Nishijo, K. Shibata, Y. Shima, S. Nagayama,

T. Katagiri, Y. Nakamura, T. Nakamura, and J. Toguchida: Disruption of fibroblast growth factor signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitor to molecular target therapy. Clinical Cancer Research, 11:2702-2712, 2005

846. T. Hirota, Y. Suzuki, K. Hasegawa, K. Obara, A. Matsuda, M. Akahoshi, K. Nakashima, L. Cheng, N. Takahashi, M. Shimizu, S. Doi, K. Fujita, T. Enomoto, M. Ebiwsawa, S. Yoshihara, Y. Nakamura, F. Kishi, T. Shirakawa, and M. Tamari: Functional haplotypes of IL-12B are associated with childhood atopic asthma. J Allergy Clin Immunol, 116:789-795, 2005

847. A. Matsuda, T. Hirota, M. Akahoshi, M. Shimizu, M. Tamari, A. Miyatake, A. Takahashi, K. Nakashima, N. Takahashi, K. Obara, N.Yuyama, S. Doi, Y. Kamogowa, T. Enomoto, K. Ohshima, T. Tsunoda, S. Miyatake, K. Fujita, M. Kusakabe, K. Izuhara, Y. Nakamura, J. Hopkin, and T.Shirakawa: Coding SNP in tenascin-C Fn-Ⅲ-D domain associates with adult asthma. Human Molecular Genetics, 14:2779-2786, 2005

848. T. Mushiroda, S. Saito, Y. Tanaka, J. Takasaki, N. Kamatani, Y. Beck, H. Tahara, Y. Nakamura, and Y. Ohnishi: A model of prediction system for adverse cardiovascular reactions by calcineurin inhibitors among patients with renal transplants using gene-based single-nucleotide polymorphisms. Journal of Human Genetics, 50:442-447, 2005

849. T. Miyazaki, M. Ono, W.-M. Qu, M.-C. Zhang, S. Mori, S. Nakatsuru, Y. Nakamura, T. Sawasaki, Y. Endo and M. Nose: Implication of allelic polymorphism of osteopontin in the development of lupus nephritis in MRL/lpr mice. Eur. J. Immunol., 35:1510–1520, 2005

850. Y. Sasaki, Y. Naishiro, Y. Oshima, K. Imai, Y. Nakamura and T. Tokino: Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes. Oncogene, 24:5131–5136, 2005

851. M. Sakai, T. Shimokawa, T. Kobayashi, S. Matsushima, Y. Yamada, Y. Nakamura, and Y. Furukawa: Elevated expression of C10orf3 (chromosome 10 open reading frame 3) is involved in the growth of human colon tumor. Oncogene, 25:480-486, 2006

852. R. Hamamoto, F. P. Silva, M. Tsuge, T. Nishidate, T. Katagiri, Y. Nakamura and Y. Furukawa: Enhanced SMYD3 expression is essential for the growth of breast cancer cells. Cancer Science, 97:113-118, 2006

853. K. Obama, T. Kato, S. Hasegawa, S. Satoh, Y. Nakamura, and Y. Furukawa: Overexpression of peptidyl-prolyl isomerase-like 1 is associated with the growth of colon cancer cells. Clinical Cancer Research, 12:70-76, 2006

854. A. Iida, S. Saito, A. Sekine, A. Takahashi, N. Kamatani, and Y. Nakamura: Japanese single nucleotide polymorphism database for 267 possible drug-related genes. Cancer Science, 97:16-24, 2006

855. T. Kikuchi, Y. Daigo, N. Ishikawa, T. Katagiri, T. Tsunoda, S. Yoshida, and Y. Nakamura: Expression profiles of metastatic brain tumor from lung adenocarcinomas on cDNA microarray. International Journal of Oncology, 28:799-805, 2006

856. T. Mushiroda, Y. Ohnishi, S. Saito, A. Takahashi, Y. Kikuchi, S. Saito, H. Shimomura, Y. Wanibuchi, T. Suzuki, N. Kamatani, and Y. Nakamura: Association of VKORC1 and CYP2C9 polymorphisms with warfarin dose requirements in Japanese patients. Journal of Human Genetics, 51:249-253, 2006

857. T. Suda, T. Tsunoda, N. Uchida, T. Watanabe, S. Hasegawa, S. Satoh, S. Ohgi, Y. Furukawa, Y. Nakamura, and H. Tahara: Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray. Cancer Science, 97:411-419, 2006

858. K. Yoshiura, A. Kinoshita, T. Ishida, A. Ninokata,T. Ishikawa, T. Kaname, M. Bannai, K. Tokunaga, S. Sonoda, R. Komaki, M. Ihara, V. Saenko, A. G. Kaimovich, I. Sekine, K. Komatsu, H. Takahashi, M. Nakashima, N. Sosonkina, C. K. Mapendano, M. Ghadami, M. Nomura, D.-S. Linag, D.-K. Kim, A. Garidkhuu, N. Natsume, T. Ohta, H. Tomita, K. Hirayama, M. Ishibashi, A. Takahashi, N. Saito, S. Saitou, Y. Nakamura, and N, Niikawa: A SNP in the ABCC11 gene is the determinant of human earwax type. Nature Genetics, 38:324-330, 2006

859. T. Yamabuki, Y. Daigo, T. Kato, S. Hayama, T. Tsunoda, M. Miyamoto, T. Ito, M. Fujita, M. Hosokawa, S. Kondo, and Y. Nakamura: Genome-wide gene expression profile analysis of esophageal squamous cell carcinomas. International Journal of Oncology, 28:1375-1384, 2006

860. A. Iida, H. Kizawa, Y. Nakamura, and S. Ikegawa: High-resolution SNP map of ASPN, a susceptibility gene for osteoarthritis. Journal of Human Genetics, 51:151-154, 2006

861. F. P. Silva, R. Hamamoto, Y. Furukawa, and Y. Nakamura: TIPUH1 encodes a novel KRAB zinc-finger protein highly expressed in human hepatocellular carcinomas. Oncogene, 25:5063-5070, 2006

862. K. Nakashima, T. Hirota, Y. Suzuki, A. Matsuda, M. Akahoshi, M. Shimizu, A. Jodo, S. Doi, K. Fujita, M. Ebisawa, S. Yoshihara,T. Enomoto, T. Shirakawa, F. Kishi, Y. Nakamura, and M. Tamari: Association of the RIP2 gene with childhood atopic asthma. Allergology International, 1:77-83, 2006

863. K. Nakashima, T. Hirota, K. Obara, M. Shimizu, A. Jodo, M. Kameda, S. Doi, K. Fujita, T. Shirakawa, T. Enomoto, F. Kishi, S. Yoshihara, K. Matsumoto, H. Saito, Y. Suzuki, Y.Nakamura, and M. Tamari: An association study of asthma and related phenotypes with polymorphisms in

negative regulator molecules of the TLR signaling pathway. Journal of Human Genetics, 51:284-291, 2006

864. S. Ashida, M. Furihata, T. Katagiri, K. Tamura, Y. Anazawa, H. Yoshioka, T. Miki, T. Fujioka, T. Shuin, Y. Nakamura, and H. Nakagawa: Expression of a novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high gleason score and prostate cancer progression. Clinical Cancer Research, 12:2767-2773, 2006

865. N. Ishikawa, Y. Daigo, A. Takano, M. Taniwaki, T. Kato, S. Tanaka, W. Yasui, Y. Takeshima, K. Inai, H. Nishimura, E. Tsuchiya, N. Kohno, and Y. Nakamura: Characterization of SEZ6L2 cell-surface protein as a novel prognostic marker for lung cancer. Cancer Science, 97:737-745, 2006

866. T. Kobayashi, T. Masaki, M. Sugiyama, Y. Atomi, Y. Furukawa, and Y. Nakamura: A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells. International Journal of Oncology, 29:341-347, 2006

867. M. Taniwaki, Y. Daigo, N. Ishikawa, A. Takano, T. Tsunoda, W. Yasui, K. Inai, N. Kohno, and Y. Nakamura: Gene expression profiles of small-cell lung cancers: molecular signatures of lung cancer. International Journal of Oncology, 29:567-575, 2006

868. E. Hirota, L. Yan, T. Tsunoda, S. Ashida, M. Fujime, T. Shuin, T. Miki, Y. Nakamura and T. Katagiri: Genome-wide gene expression profiles of clear cell renal cell carcinoma; International Journal of Oncology, 29:799-827, 2006

869. J.-H. Park, M.-l. Lin, T. Nishidate, Y. Nakamura, and T. Katagiri: PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer. Cancer Research, 66:9186-9195, 2006

870. K. Ozaki, H. Sato, A. Iida, H. Mizuno, T. Nakamura, Y. Miyamoto, A. Takahashi, T. Tsunoda, S. Ikegawa, N. Kamatani, M. Hori, Y. Nakamura, and T. Tanaka: A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population. Nature Genetics, 38:921-925, 2006

871. N. Jinawath, Y. Chamgramol, Y. Furukawa, K. Obama, T. Tsunoda, B. Sripa, C. Pairojkul, and Y. Nakamura: Comparison of gene expression profiles between opisthorchis viverrini and non-0pisthorchis viverrini associated human intrahepatic cholangiocarcinoma. Hepatology, 44:1025-1038, 2006

872. Y. Nakamura, M. Futamura, H. Kamino, K. Yoshida,Y. Nakamura, and H. Arakawa: Identification of p53-46F as a super p53 with an enhanced ability to induce p53-dependent apoptosis. Cancer Science, 97:633-641, 2006

873. A. Takehara, H. Eguchi, H. Ohigashi, O. Ishikawa, T. Kasugai, M. Hosokawa, T. Katagiri, Y. Nakamura, and H. Nakagawa: Novel tumor marker, REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4. Cancer Science, 97:1191-1197, 2006

874. M. Iiizumi, H. Nakagawa, M. Hosokawa, A. Takehara, C. Su-Youn, T. Nakamura, T. Katagiri, H. Eguchi, H. Ohigashi, O. Ishikawa, Y. Nakamura, and H. Nakagawa: EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth. Cancer Science, 97:1211-1216, 2006

875. K. Takahashi, C. Furukawa, A. Takano, N. Ishikawa, T. Kato, S. Hayama, C. Suzuki, W. Yasui, K. Inai, S. Sone, T. Ito, H. Nishimura, E. Tsuchiya, Y. Nakamura and Y. Daigo: The neuromedin u-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer. Cancer Research, 66:9408-9419, 2006

876. S. Hayama, Y. Daigo, T. Kato, N. Ishikawa, T. Yamabuki, M. Miyamoto, T. Ito, E. Tsuchiya, S. Kondo, and Y. Nakamura: Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis. Cancer Research, 66:10339-10348, 2006

877. K. Ura, K. Obama, S. Satoh, Y. Sakai, Y. Nakamura, and Y. Furukawa: Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma. Clinical Cancer Research, 12:6611-6616, 2006

878. N. Ishii, K. Ozaki, H. Sato, H. Mizuno, S. Saito, A. Takahashi, Y. Miyamoto, S. Ikegawa, N. Kamatani, M. Hori, S. Saito, Y. Nakamura and T. Tanaka: Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial Infarction. Journal of Human Genetics, 51:1087-1099, 2006

879. S. Mahasirimongkol, W. Chantratita, S. Promso, E. Pasomsab, N. Jinawath, W. Jongjaroenprasert, V. Lulitanond, P. Krittayapoositpot, S. Tongsima, P. Sawanpanyalert, N. Kamatani, Y. Nakamura, and T. Sura: Similarity of the allele frequency and linkage disequilibrium pattern of single nucleotide polymorphisms in drug-related gene loci between Thai and northern East Asian populations: implications for tagging SNP selection in Thais. Journal of Human Genetics, 51:896-904, 2006

880. Y. Nakazaki, H. Hase, H. Inoue, Y.Beppu, M. Xin, G. Sakaguchi, R. Kurita, S. Asano, Y. Nakamura, and K. Tani: Serial analysis of gene expression in progressing and regressing mouse tumor implicates the involvement of RANTES andTARC in antitumor immune responses. Molecular Therapy, 14:599-606, 2006

881. M. Kato, A. Sekine, Y. Ohnishi, T. A. Johnson, T. Tanaka, Y. Nakamura, and T. Tsunoda: Linkage

disequilibrium of evolutionarily conserved regions in the human genome. BMC Genomics, 7:326-333, 2006

882. T. Hirota, K. Hasegawa, K. Obara, A. Matsuda, M. Akahoshi, K. Nakashima, T. Shirakawa, S. Doi, K. Fujita, Y. Suzuki, Y. Nakamura and M. Tamari: Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clinical & Experimental Allergy, 364:884-891, 2006

883. S. Tachiiri, T. Katagiri, T. Tsunoda, N. Oya, M. Hiraoka, and Y. Nakamura: Analysis of gene-expression profiles after gamma irradiation of normal human fibroblasts. International Journal of Radiation Oncology*Biology*Physics, 64:272-277, 2006

884. A. Shimo, T. Nishidate, T. Ohta, M. Fukuda and Y. Nakamura, and T. Katagiri: Elevated expression of protein regulator of cytokinesis 1, involved in the growth of breast cancer cells. Cancer Science, 98:174-181, 2007

885. T. Kato, S. Hayama, T. Yamabuki, N. Ishikawa, M. Miyamoto, T. Ito, E. Tsuchiya, S. Kondo, Y. Nakamura, and Y. Daigo: Increased expression of insulin-like growth factor-Ⅱ messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer. Clinical Cancer Research, 13:434-442, 2007

886. M. Kanehira, T. Katagiri, A. Shimo, R. Takata, T. Shuin, T. Miki, T. Fujioka, and Y. Nakamura: Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer. Cancer Research, 67:3276-3285, 2007

887. M. Kubo, J. Hata, T. Ninomiya, K. Matsuda, K. Yonemoto, T. Nakano, T. Matsushita, K. Yamazaki, Y. Ohnishi, S. Saito, T. Kitazono, S. Ibayashi, K. Sueishi, M. Iida, Y. Nakamura, and Y. Kiyohara: A nonsynonymous SNP in PRKCH increases the risk of cerebral infarction. Nature Genetics, 39:212-217, 2007

888. C. Suzuki, K. Takahashi, S. Hayama, N. Ishikawa, T. Kato, T. Ito, E. Tsuchiya, Y. Nakamura, and Y. Daigo: Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer. Molecular Cancer Therapeutics, 6:542-551, 2007

889. T. Yamabuki, A. Takano, S. Hayama, N. Ishikawa, T. Kato, M. Miyamoto, T. Ito, H. Ito, Y. Miyagi, H. Nakayama, M. Fujita, M. Hosokawa, E. Tsuchiya, N. Kohno, S. Kondo, and Y. Nakamura, and Y. Daigo: Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas. Cancer Research, 67:2517-2525, 2007

890. K. Saigusa, I. Imoto, C. Tanikawa, M. Aoyagi, K. Ohno, Y. Nakamura, and J. Inazawa: RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. Oncogene, 26:1110-1121, 2007

891. Y. Ebana, K. Ozaki, K. Inoue, H. Sato, A. Iida, H. Lwin, S. Saito, H. Mizuno, A. Takahashi, T. Nakamura, Y. Miyamoto, S. Ikegawa, K. Odashiro, M. Nobuyoshi, N. Kamatani, M. Hori, M. Isobe, Y. Nakamura, and T. Tanaka: A functional SNP in ITIH3 is associated with susceptibility to myocardial infarction. Journal of Human Genetics, 52:220-229, 2007

892. M.-L. Lin, J.-H. Park, T. Nishidate, Y. Nakamura, and T. Katagiri: Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. Breast Cancer Research, 9:R17, 2007

893. R. Takata, T. Katagiri, M. Kanehira, T. Shuin, T. Miki, M. Namiki, K. Kohri, T. Tsunoda, T. Fujioka, and Y. Nakamura: Validation study of the prediction system for clinical response of M-VAC neoadjuvant chemotherapy. Cancer Science, 98:113-117, 2007

894. M. Hosokawa, A. Takehara, K. Matsuda, H. Eguchi, H. Ohigashi, O. Ishikawa, Y. Shinomura, K. Imai, Y. Nakamura, and H. Nakagawa: Oncogenic role of KIAA0101 interacting with proliferating cell nuclear antigen in pancreatic cancer. Cancer Research, 67:2568-2576, 2007

895. J. Hata, K. Matsuda, T. Ninomiya, K. Yonemoto, T. Matsushita, Y. Ohnishi, S. Saito, T. Kitazono, S. Ibayashi, M. Iida, Y. Kiyohara, Y. Nakamura, and M. Kubo: Functional SNP in a Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction. Human Molecular Genetics, 16:630-639, 2007

896. N. Osawa, D. Koga, S. Araki, T. Uzu,T. Tsunoda, A. Kashiwagi, Y. Nakamura, and S. Maeda: Combinational effect of genes for the renin-angiotensin system in conferring susceptibility to diabetic nephropathy. Journal of Human Genetics, 52:143-151, 2007

897. Y. Onouchi, M. Tamari, A. Takahashi, T. Tsunoda, M. Yashiro, Yo. Nakamura, H. Yanagawa, K. Wakui, Y. Fukushima, T. Kawasaki, Yu. Nakamura, and A. Hata: A gennomewide linkage analysis of Kawasaki disease: evidence for linkage to chromosome 12. Journal of Human Genetics, 52:179-190, 2007

898. Y. Miyamoto, A. Mabuchi, D. Shi, T. Kubo, Y. Takatori, S. Saito, M. Fujioka, A. Sudo, A. Uchida, S. Yamamoto, K. Ozaki, M. Takigawa, T. Tanaka, Y. Nakamura, Q. Jiang, and S. Ikegawa: A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. Nature Genetics, 39:529-533, 2007

899. M. Kanehira, Y. Harada, R. Takata, T. Shuin, T. Miki, T. Fujioka, Y. Nakamura and T. Katagiri: Involvement of upregulation of DEPDC1 (DEP domain containing 1) in bladder carcinogenesis. Oncogene, 26:6448-6455, 2007

900. S. Hayama, Y. Daigo, T. Yamabuki, D. Hirata, T. Kato, M. Miyamoto, T. Ito, E. Tsuchiya, S. Kondo, and Y. Nakamura: Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis. Cancer Research,

67:4113-4122, 2007 901. K. Tamura, M. Furihata, T. Tsunoda, S. Ashida, R. Takata, W. Obara, H. Yoshioka, Y. Daigo, Y.

Nasu, H. Kumon, H. Konaka, M. Namiki, K. Tozawa, K. Kohri, N. Tanji, M. Yokoyama, T. Shimazui, H. Akaza, Y. Mizutani, T. Miki, T. Fujioka, T. Shuin, Y. Nakamura, and H. Nakagawa: Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression profiles. Cancer Research, 67:5117-5125, 2007

902. A. Bourdon, L. Minai, V. Serre, J.-P. Jais, E. Sarzi, S. Aubert, D. Chretien, P. de Lonlay, V. Paquis-Flucklinger, H. Arakawa, Y. Nakamura, A. Munnich, and A. Rotig: Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nature Genetics, 39:776-780, 2007

903. K. M. Giacomini, R. M. Krauss, D. M. Roden, M. Eichelbaum, M. R. Hayden, and Y. Nakamura: When good drugs go bad (commentary). Nature, 446:975-977, 2007

904. H. Zembutsu, M. Yanada, A. Hishida, T. Katagiri, T. Tsuruo, I. Sugiura, J. Takeuchi, N. Usui, T. Naoe, Y. Nakamura, and R. Ohno: Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy. International Journal of Oncology, 31:313-322, 2007

905. M. Fujikawa, T. Katagiri, A. Tugores, Y. Nakamura, and F. Ishikawa: ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence. Cancer Science, 98:1468-1475, 2007

906. T. Kato, N. Sato, S. Hayama, T. Yamabuki, T. Ito, M. Miyamoto, S. Kondo, Y. Nakamura, and Y. Daigo: Activation of holliday junction-recognizing protein involved in the chromosomal stability and immortality of cancer cells. Cancer Research, 67:8544-8553, 2007

907. K. Ueda, T. Katagiri, T. Shimada, S. Irie, T. Sato, Y. Nakamura, and Y. Daigo: Comparative profiling of serum glycoproteome by sequential purification of glycoproteins and 2-nitrobenzensulfenyl (NBS) stable isotope labeling: a new approach for the novel biomarker discovery for cancer. Journal of Proteome Research, 6:3475-3483, 2007

908. M. Taniwaki, A. Takano, N. Ishikawa, W. Yasui, K. Inai, H. Nishimura, E. Tsuchiya, N. Kohno, Y. Nakamura, and Y. Daigo: Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer. Clinical Cancer Research, 13:6624-6631, 2007

909. T. Suda, T. Tsunoda, Y. Daigo, Y. Nakamura, and H. Tahara: Identification of HLA-A24-restricted epitope-peptides derived from gene products upregulated in lung and esophageal cancers as novel targets for immunotherapy. Cancer Science, 98:1803-1808, 2007

910. Y. Mano, K. Takahashi, N. Ishikawa, A. Takano, W. Yasui, K. Inai, H. Nishimura, E. Tsuchiya, Y. Nakamura, and Y. Daigo: Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. Cancer Science, 98:1902-1913, 2007

911. S. Senju, H. Suemori, H. Zembutsu, Y. Uemura, S. Hirata, D. Fukuma, H. Matsuyoshi, M. Shimomura, M. Haruta, S. Fukushima, Y. Matsunaga, T. Katagiri, Y. Nakamura, M. Furuya, N. Nakatsuji, and Y. Nishimura: Genetically manipulated human embryonic stem cell-derived dendritic cells with immune regulatory function. Stem Cells, 25:2720-2729, 2007

912. P.-C. Cha, T. Mushiroda, A. Takahashi, S. Saito, H. Shimomura, Y. Wanibuchi, T. Suzuki, N. Kamatani, and Y. Nakamura: High-resolution SNP and haplotype maps of the human gamma-glutamyl carboxylase gene (GGCX) and association study between polymorphisms in GGCX with warfarin maintenance-dose requirement of the Japanese population. Journal of Human Genetics, 52:856-864, 2007

913. K. Yamazaki, Y. Onouchi, M. Takazoe, M. Kubo, Y. Nakamura, and A. Hata: Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. Journal of Human Genetics, 52:575-583, 2007

914. Y. Tsukumo, A. Tomida, O. Kitahara, Y. Nakamura, S. Asada, K. Mori, and T. Tsuruo: Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation. Journal of Biological Chemistry, 282:29264-29272, 2007

915. A. Takehara, M. Hosokawa, H. Eguchi, H. Ohigashi, O. Ishikawa, Y. Nakamura, and H. Nakagawa: γ-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor π subunit. Cancer Research, 67:9704-9712, 2007

916. M. Kunizaki, R. Hamamoto, F. P. Silva, K. Yamaguchi, T. Nagayasu, M. Shibuya, Y. Nakamura, and Y. Furukawa: The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3. Cancer Research, 67:10759-10765, 2007

917. S. Kudo, R. Konda, W. Obara, D. Kudo, K. Tani, Y. Nakamura, and T. Fujioka: Inhibition of tumor growth through suppression of angiogenesis by brain-specific angiogenesis inhibitor 1 gene transfer in murine renal cell carcinoma. Oncology Reports, 18:785-791, 2007

918. The International HapMap Consortium:, A second generation human haplotype map of over 3.1 million SNPs. Nature, 449:851-861, 2007

919. P. C. Sabeti, P. Varilly, B. Fry, J. Lohmueller, E. Hostetter, C. Cotsapas, X. Xie, E. H. Byrne, S. A. McCarroll, R. Gaudet, S. F. Schaffner, E. S. Lander, and The International HapMap Consortium: Genome-wide detection and characterization of positive selection in human populations. Nature, 449:913-918, 2007

920. N. Ishikawa, A. Takano, W. Yasui, K. Inai, H. Nishimura, H. Ito, Y. Miyagi, H. Nakayama, M. Fujita, M. Hosokawa, E. Tsuchiya, N. Kohno, Y. Nakamura, and Y. Daigo: Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas. Cancer Research, 67:11601-11611, 2007

921. T. Yanagiya, A. Tanabe, A. Iida, S. Saito, A. Sekine, A. Takahashi, T. Tsunoda, S. Kamohara, Y. Nakata, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, S. Miyazaki, K. Tokunaga, M. Kawamoto, T. Funahashi, K. Hamaguchi, K. Tanaka, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, N. Kamatani, Y. Nakamura, and K. Hotta: Association of single-nucleotide polymorphisms in MTMR9 gene with obesity. Human Molecular Genetics, 16:3017-3026, 2007

922. M. Kamiyama, M. Kobayashi, S. Araki, A. Iida, T. Tsunoda, K. Kawai, M. Imanishi, M. Nomura, T. Babazono, Y. Iwamoto, A. Kashiwagi, K. Kaku, R. Kawamori, D.P.K. Ng, T. Hansen, P. Gaede, O. Pedersen, Y. Nakamura, and S. Maeda: Polymorphisms in the 3'UTR in the neurocalcin δ gene affect mRNA stability, and confer susceptibility to diabetic nephropathy. Human Genetics, 122:397-407, 2007

923. S. Takitoh, S. Fujii, Y. Mase, J. Takasaki, T. Yamazaki, Y. Ohnishi, M. Yanagisawa, Y. Nakamura, and N. Kamatani: Accurate automated clustering of two-dimensional data for single-nucleotide polymorphism genotyping by a combination of clustering methods: evaluation by large-scale real data. Bioinformatics, 23:408-413, 2007

924. J. Kwong, L, Shuk-Nga Chow, A. Yue-Hang Wong, W.-K. Hung, G. Tin-Yun Chung, K.-F. To, F.L. Chan, Y. Daigo, Y. Nakamura, D.P. Huang, and K.-W. Lo: Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma. Genes Chromosomes and Cancer, 46:171–180, 2007

925. A. Tanabe, T. Yanagiya, A. Iida, S. Saito, A. Sekine, A. Takahashi, T. Nakamura, T. Tsunoda, S. Kamohara, Y. Nakata, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, T. Funahashi, S. Miyazaki, K. Tokunaga, K. Hamaguchi, T. Shimada, K. Tanaka, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, T. Sakata, Y. Matsuzawa, N. Kamatani, Y. Nakamura, and K. Hotta: Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity . Journal of Clinical Endocrinology and Metabolism, 92:1145-1154, 2007

926. Y. Aoki, A. Toyama, T. Shimada, T. Sugita, C. Aoki, Y. Umino, A. Suzuki, D. Aoki, Y. Daigo, Y. Nakamura, and TA Sato: A novel method for analyzing formalin-fixed paraffin embedded (FFPE) tissue sections by mass spectrometry imaging. Proceedings of the Japan Academy. Series B-Physical and Biological Sciences, 83:205-214, 2007

927. M. Harada, K. Nakashima, T. Hirota, M. Shimizu, S. Doi, K. Fujita, T. Shirakawa, T. Enomoto, M. Yoshikawa, H. Moriyama, K. Matsumoto, H. Saito, Y. Suzuki, Y. Nakamura, and M. Tamari: Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. American Journal of Respiratory Cell and Molecular Biology , 36:491-496, 2007

928. T. Kidokoro, C. Tanikawa, Y. Furukawa, T. Katagiri, Y. Nakamura, and K. Matsuda: CDC20, a potential cancer therapeutic target, is negatively regulated by p53. Oncogene, 27:1562-1571, 2008

929. N. Hosono, M. Kubo, Y. Tsuchiya, H. Sato, T. Kitamoto, S. Saito, Y. Ohnishi, and Y. Nakamura: Multiplex PCR-based real-time Invader assay (mPCR-RETINA): a novel SNP-based method for detecting allelic asymmetries within copy number variation regions. Human Mutation, 29:182-189, 2008

930. Y. Onouchi, T. Gunji, J. C. Burns, C. Shimizu, J.W. Newburger, M. Yashiro, Yo. Nakamura, H.Yanagawa, K. Wakui, Y. Fukushima, F. Kishi, K. Hamamoto, M. Terai, Y. Sato, K. Ouchi, T. Saji, A. Nariai, Y. Kaburagi, T. Yoshikawa, K. Suzuki, T. Tanaka, T. Nagai, H. Cho, A. Fujino, A. Sekine, R. Nakamichi, T. Tsunoda, T. Kawasaki, Yu. Nakamura, and A. Hata: ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nature Genetics, 40:35-42, 2008

931. F. P. Silva, R. Hamamoto, M. Kunizaki, M. Tsuge, Y. Nakamura, and Y. Furukawa: Enhanced methyltransferase activity of SMYD3 by the cleavage of its N-terminal region in human cancer cells. Oncogene, 27:2686-2692, 2008

932. K. Obama, S. Satoh, R. Hamamoto, Y. Sakai, Y. Nakamura, and Y. Furukawa: Enhanced expression of RAD51 associating protein-1 is involved in the growth of intrahepatic cholangiocarcinoma cells. Clinical Cancer Research, 14:1333-1339, 2008

933. M. Kato, F. Miya, Y. Kanemura, T. Tanaka, Y. Nakamura, and T. Tsunoda: Recombination rates of genes expressed in human tissues. Human Molecular Genetics, 17:577-586, 2008

934. A. C. C. Leung,, V. C. L. Wong, L. C. Yang, P. L. Chan, Y. Daigo, Y. Nakamura, R. Z. Qi, L. Miller, E. T.-K. Liu, L. D. Wang, J.-L. Li, S. Law, S. W. Tsao, and M. L. Lung: Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma. International Journal of Cancer, 122:587-594, 2008

935. A. Shimo, C. Tanikawa, T. Nishidate, K. Matsuda, M.-L. Lin, J.-H. Park, T. Ohta, K. Hirata, M. Fukuda, Y. Nakamura, and T. Katagiri: Involvement of KIF2C/MCAK overexpression in mammary

carcinogenesis. Cancer Science, 99:62-70, 2008 936. M. Uemura, K. Tamura, S. Chung, S. Honma, A. Okuyama, Y. Nakamura, and H. Nakagawa:

Novel 5α-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Science, 99:81-86, 2008

937. Y. Kamatani, K. Matsuda, T. Ohishi, S. Ohtsubo, K. Yamazaki, A. Iida, N. Hosono, M. Kubo, W. Yumura, K. Nitta, T. Katagiri, Y. Kawaguchi, N. Kamatani, and Y. Nakamura: Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population. Journal of Human Genetics, 53:64-73, 2008

938. C. Fukukawa, H. Hanaoka, S. Nagayama, T. Tsunoda, J. Toguchida, K. Endo, Y. Nakamura, and T. Katagiri: Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10. Cancer Science, 99:432-440, 2008

939. J. Brunet, A. W. Pfaff, A. Abidi, M. Unoki, Y. Nakamura, M. Guinard, J.-P. Klein, E. Candolfi, and M. Mousli: Toxoplasma gondii exploits UHRF1 and induces host cell cycle arrest at G2 to enable its proliferation. Cellular Microbiology, 10:908-920, 2008

940. N. Kato, T. Miyata, Y. Tabara, T. Katsuya, K. Yanai, H. Hanada, K. Kamide, J. Nakura, K. Kohara, F. Takeuchi, H. Mano, M. Yasunami, A. Kimura, Y. Kita, H. Ueshima, T. Nakayama, M. Soma, A. Hata, A. Fujioka, Y. Kawano, K. Nakao, A. Sekine, T. Yoshida, Y. Nakamura, T. Saruta, T. Ogihara, S. Sugano, T. Miki, and H. Tomoike: High-density association study and nomination of susceptibility genes for hypertension in the Japanese national project. Human Molecular Genetics, 17:617-627, 2008

941. T. Oishi, A. Iida, S. Otsubo, Y. Kamatani, M. Usami, T. Takei, K. Uchida, K. Tsuchiya, S. Saito, Y. Ohnisi, K. Tokunaga, K. Nitta,Y. Kawaguchi, N. Kamatani, Y. Kochi, K. Shimane, K. Yamamoto, Y. Nakamura, W. Yumura, and K. Matsuda: A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to Systemic Lupus Erythematosus in Japanese population. Journal of Human Genetics, 53:151-162, 2008

942. Y. Daigo, Y. Nakamura: From cancer genomics to thoracic oncology: discovery of new biomarkers and therapeutic targets for lung and esophageal carcinoma. (review article) General Thoracic and Cardiovascular Surgery, 56:43-53, 2008

943. K. Kiyotani, T. Mushiroda, M. Kubo, H. Zembutsu, Y. Sugiyama, and Y. Nakamura: Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Cancer Science, 99:967-972, 2008

944. K. Kiyotani, T. Mushiroda, M. Sasa, Y. Bando, I. Sumitomo, N. Hosono, M. Kubo, Y. Nakamura, and H. Zembutsu: Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy. Cancer Science, 99:995-999, 2008

945. T. Kato, N. Sato, A. Takano, M. Miyamoto, H. Nishimura, E. Tsuchiya, S. Kondo, Y. Nakamura, and Y. Daigo: Activation of placenta-specific transcription factor distal-less homeobox 5 predicts clinical outcome in primary lung cancer patients. Clinical Cancer Research, 14:2363-2370, 2008

946. A. Tenesa, S.M. Farrington, J.G.D. Prendergast, M.E. Porteous, M. Walker, N. Haq, R.A. Barnetson, E. Theodoratou, R. Cetnarskyj, N. Cartwright, R. Wilson, C. Semple, A.J. Clarke, F.J.L. Reid, L.A. Smith, K. Kavoussanakis, T. Kossler, P.D.P. Pharoah, S. Buch, C. Schafmayer, J. Tepel, S. Schreiber, H. Volzke, C.O. Schmidt, J. Hampe, S. Wilkening, F. Canzian, J. Chang-Claude, M. Hoffmeister, H. Brenner, G. Capella, V. Moreno, I.J. Deary, J.M. Starr, I.P.M. Tomlinson, E. Webb, R.S. Houlston, G. Rennert, D. Ballinger, L. Rozek, S.B. Gruber, K. Matsuda, T. Kidokoro, Y. Nakamura, B.W. Zanke, C.M.T. Greenwood, J. Rangrej, R. Kustra, A. Montpetit, T.J. Hudson, S. Gallinger, H. Campbell, and M.G. Dunlop: A genome-wide association scan identifies colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nature Genetics, 40:631-637, 2008

947. H. Mototani, A. Iida, M. Nakajima, T. Furuichi, Y. Miyamoto, T. Tsunoda, A. Sudo, A. Kotani, A. Uchida, K. Ozaki, Y. Tanaka, Y. Nakamura, T. Tanaka, K. Notoya, and S. Ikegawa: A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese. Human Molecular Genetics, 17:1790-1797, 2008

948. Y. Mizukami, K. Kono, Y. Daigo, A. Takano, T. Tsunoda, Y. Kawaguchi, Y. Nakamura, and H. Fujii: Detection of novel Cancer-Testis antigen-specific T-cell responses in TIL, regional lymph nodes and PBL in patients with esophageal squamous cell carcinoma. Cancer Science, 99:1448-1454, 2008

949. T. Mushiroda, S. Wattanapokayakit, A. Takahashi, T. Nukiwa, S. Kudoh, T. Ogura, H. Taniguchi, Pirfenidone Clinical Study Group, M. Kubo, N. Kamatani, and Y. Nakamura: A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis. Journal of Medical Genetics, 45:654-656, 2008

950. M. Hosokawa, K. Kashiwaya, M. Furihara, H. Eguchi, H. Ohigashi, O. Ishikawa, Y. Shinomura, K. Imai, Y. Nakamura, and H. Nakagawa: Overexpression of cysteine proteinase inhibitor cystatin 6 promotes pancreatic cancer growth. Cancer Science, 99:1626-1632, 2008

951. The Study Group of Millennium Genome Project for Cancer, (H. Sakamoto, K. Yoshimura, N. Saeki, H. Katai, T. Shimoda, Y. Matsuno, D. Saito, H. Sugimura, F. Tanioka, S. Kato, N. Matsukura, N. Matsuda, T. Nakamura, I. Hyodo, T. Nishina, W. Yasui, H. Hirose, M. Hayashi, E. Toshiro, S. Ohnami, A. Sekine, Y. Sato, H. Totsuka, M. Ando, R. Takemura, Y. Takahashi, M.

Ohdaira, K. Aoki, I. Honmyo, S. Chiku, K. Aoyagi, H. Sasaki, S. Ohnami, K. Yanagihara, K.-A. Yoon, M.-C. Kook, Y.-S. Lee, S. R. Park, C. G. Kim, I. J. Choi, T. Yoshida, Y. Nakamura, and S. Hirohashi): Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. Nature Genetics, 40:730-740, 2008

952. T. Ueki, T. Nishidate, J.H. Park, M.L. Lin, A. Shimo, K. Hirata, Y. Nakamura, and T. Katagiri: Involvement of elevated expression of multiple cell-cycle regulator, DTL/RAMP (denticleless /RA-regulated nuclear matrix associated protein), in the growth of breast cancer cells. Oncogene, 27:5672-5683, 2008

953. Y. Miyamoto, D. Shi, M. Nakajima, K. Ozaki, A. Sudo, A. Kotani, A. Uchida, T. Tanaka, N. Fukui, T. Tsunoda, A. Takahashi, Y. Nakamura, Q. Jiang, and S. Ikegawa: Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis. Nature Genetics, 40:994-998, 2008

954. H. Unoki, A. Takahashi, T. Kawaguchi, K. Hara, M. Horikoshi, G. Andersen, D.P.K. Ng, J. Holmkvist, K. Borch-Johnsen, T. J. Rgensen, A. Sandbaek, T. Lauritzen, T. Hansen, S. Nurbaya, T. Tsunoda, M. Kubo, T. Babazono, H. Hirose, M. Hayashi, Y. Iwamoto, A. Kashiwagi, K. Kaku, R. Kawamori, E. S. Tai, O. Pedersen, N. Kamatani, T. Kadowaki, R. Kikkawa, Y. Nakamura, and S. Maeda: SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nature Genetics, 40:1098-1102, 2008

955. M. Harao , S. Hirata, A. Irie, S. Senju, T. Nakatsura, H. Komori, Y. Ikuta, K. Yokomine, K. Imai, M. Inoue, K. Harada, T. Mori, T. Tsunoda, S. Nakatsuru, Y. Daigo, H. Nomori, Y. Nakamura, H. Baba, and Y. Nishimura: HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL. International Journal of Cancer, 123:2616-2625, 2008

956. K. Imai, S. Hirata, A. Irie, S. Senju, Y. Ikuta, K. Yokomine, M. Harao, M. Inoue, T. Tsunoda, S. Nakatsuru, H. Nakagawa, Y. Nakamura, H. Baba, and Y. Nishimura: Identification of a novel tumor-associated antigen, cadherin 3/P-cadherin, as a possible target for immunotherapy of pancreatic, gastric and colorectal cancers. Clinical Cancer Research, 14:6487-6495, 2008

957. D.N. Nikolova, H. Zembutsu, T. Sechanov, K. Vidinov, L.S. Kee, R. Ivanova, E. Becheva, M. Kocova, D. Toncheva, and Y. Nakamura: Genome-wide gene expression profiles of thyroid carcinoma: Identification of molecular targets for treatment of thyroid carcinoma. Oncology Reports, 20:105-121, 2008

958. Y. Nakamura: Pharmacogenomics and drug toxicity. (Editorial) New Eng. J. Med., 359:856-858, 2008

959. K. Arita, M. Ariyoshi, H. Tochio, Y. Nakamura, and M. Shirakawa: Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism. Nature, 455:818-822, 2008

960. H. Inoue, M. Iga, H. Nabeta, T. Yokoo, Y. Suehiro, S. Okano, M. Inoue, H. Kinoh, T. Katagiri, K. Takayama, Y. Yonemitsu, M. Hasegawa, Y. Nakamura, Y. Nakanishi, and K. Tani: Non-transmissible SeV encoding GM-CSF is a novel and potent vector system to produce autologous tumor vaccines. Cancer Science, 99:2315-2326, 2008

961. R. Konda, J. Sugimura, F. Sohma, T. Katagiri, Y. Nakamura, and T. Fujioka: Over expression of hypoxia-inducible protein 2, hypoxia-inducible factor-1αand nuclear factor κB is putatively involved in acquired renal cyst formation and subsequent tumor transformation in patients with end stage renal failure. The Journal of Urology, 180:481-485, 2008

962. K. Hotta, Y. Nakata, T. Matsuo, S. Kamohara, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, S. Miyazaki, K. Tokunaga, M. Kawamoto, T. Funahashi, K. Hamaguchi, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, K. Tanaka, N. Kamatani, and Y. Nakamura: Variations in the FTO gene are associated with severe obesity in the Japanese. Journal of Human Genetics, 53:546-553, 2008

963. M. Kato, Y. Nakamura, and T. Tsunoda: An algorithm for inferring complex haplotypes in a region of copy-number variation. Am. J. Human Genetics, 83:157-169, 2008

964. M. Kato, Y. Nakamura, and T. Tsunoda: MOCSphaser: a haplotype inference tool from a mixture of copy number variation and single nucleotide polymorphism data. Bioinformatics, 24:1645-1646, 2008

965. Y. Yamaguchi-Kabata, K. Nakazono, A. Takahashi, S. Saito, N. Hosono, M. Kubo, Y. Nakamura, and N. Kamatani: Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: Effects on population-based association studies. Am. J. Human Genetics, 83:445-456, 2008

966. K. Yasuda, K. Miyake, Y. Horikawa, K. Hara, H. Osawa, H. Furuta, Y. Hirota, H. Mori, A. Jonsson, Y. Sato, K. Yamagata, Y. Hinokio, H.-Y. Wang, T. Tanahashi, N. Nakamura, Y. Oka, N. Iwasaki, Y. Iwamoto, Y. Yamada, Y. Seino, H. Maegawa, A. Kashiwagi, J. Takeda, E. Maeda, H. D. Shin, Y. M. Cho, K. S. Park, H. K. Lee, M. C. Y. Ng, R. C. W. Ma, W.-Y. So, J. C. N. Chan, V. Lyssenko, T. Tuomi, P.Nilsson, L. Groop, N. Kamatani, A. Sekine, Y. Nakamura, K. Yamamoto, T. Yoshida, K. Tokunaga, M. Itakura, H. Makino, K. Nanjo, T. Kadowaki, and M. Kasuga: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nature Genetics, 40:1092-1097, 2008

967. Y. Okada, M. Mori, R. Yamada, A. Suzuki, K. Kobayashi, M. Kubo, Y. Nakamura, and K. Yamamoto: SLC22A4 polymorphism and rheumatoid arthritis susceptibility: A replication study in

a Japanese population and a metaanalysis. The Journal of Rheumatology, 35:1723-1728, 2008 968. S. Omori, Y. Tanaka, A. Takahashi, H. Hirose, A. Kashiwagi, K. Kaku, R. Kawamori, Y. Nakamura,

and S. Maeda: Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility of type 2 diabetes in a Japanese population. Diabetes, 57:791-795, 2008

969. K. Misawa, S. Fujii, T. Yamazaki, A. Takahashi, J. Takasaki, M. Yanagisawa, Y. Ohnishi, Y. Nakamura, and N. Kamatani: New correction algorithms for multiple comparisons in case-control multilocus association studies based on haplotypes and diplotype configurations. Journal of Human Genetics, 53:789-801, 2008

970. A. Suzuki, R. Yamada, Y. Kochi, T. Sawada, Y. Okada, K. Matsuda, Y. Kamatani, M. Mori, K. Shimane, Y. Hirabayashi, A. Takahashi, T. Tsunoda, A. Miyatake, M. Kubo, N. Kamatani, Y. Nakamura, and K. Yamamoto: Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population. Nature Genetics, 40:1224-1229, 2008

971. K. Hotta, M. Nakamura, Y. Nakata, T. Matsuo, S. Kamohara, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, S. Miyazaki, K. Tokunaga, M. Kawamoto T. Funahashi, K. Hamaguchi, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, K. Tanaka, N. Kamatani, and Y. Nakamura: INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese. Journal of Human Genetics, 53:857-862, 2008

972. K. Iwahori, T. Osaki, S. Serada, M. Fujimoto, H. Suzuki, Y. Kishi, A. Yokoyama, H. Hamada, Y. Fujii, K. Yamaguchi, T. Hirashima, K. Matsui, I. Tachibana, Y. Nakamura, I. Kawase, and T. Naka: Megakaryocyte potentiating factor as a tumor maker of malignant pleural mesothelioma: Evaluation in comparison with mesothelin. Lung Cancer, 62:45-54, 2008

973. T. Hirota, M. Harada, M. Sakashita, S. Doi, A. Miyatake, K. Fujita, T. Enomoto, M. Ebisawa, S. Yoshihara, E. Noguchi, H. Saito, Y. Nakamura, and M. Tamari: Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population. J Allergy Clin Immunol, 121:769-770, 2008

974. M. Sakashita, T. Yoshimoto, T. Hirota, M. Harada, K. Ohkubo, Y. Osawa, S. Fujieda, Y. Nakamura, K. Yasuda, K. Nakanishi, and M. Tamari: Association of serum interleukin-33 level and the interleukin-33 genetic variant with Japanese cedar pollinosis. Clin Exp Allergy, 38:1875-1881, 2008

975. C. Okuma, T. Kaketa, A. Hikita, K. Matsuda, M. Nakamura, Y. Nagase, Y. Oshima, M. Iwasawa, Y. Nakamura, H. Kurosawa, K. Nakamura, and S. Tanaka: Potential involvement of p53 in ischemia/reperfusion-induced osteonecrosis. Journal of Bone and Mineral Metabolism, 26:576-585, 2008

976. S. Kobayashi, K. Ikari, H. Kaneko, Y. Kochi, K. Yamamoto, K. Shimane, Y. Nakamura, Y. Toyama, T. Mochizuki, S. Tsukahara, Y. Kawaguchi, C. Terai, M. Hara, T. Tomatsu, H. Yamanaka, T. Horiuchi, K. Tao, K. Yasutomo, D. Hamada, N. Yasui, H. Inoue, M. Itakura, H. Okamoto, N. Kamatani, and S. Momohara: Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. Arthritis & Rheumatism, 58:1940–1946, 2008

977. M. Harada, T. Hirota, A.I. Jodo, S. Doi, M. Kameda, K. Fujita, A. Miyatake, T. Enomoto, E. Noguchi, S. Yoshihara, M. Ebisawa, H. Saito, K. Matsumoto, Y. Nakamura, S.F. Ziegler, and M.Tamari: Functional analysis of the Thymic Stromal Lymphopoietin Variants in Human Bronchial Epithelial Cells. Am J Respir Cell Mol Biol, 40:368-374, 2009

978. S. Chantarangsu , T. Mushiroda, S. Mahasirimongkol, S. Kiertiburanakul, S. Sungkanuparph, W. Manosuthi, W. Tantisiriwat, A. Charoenyingwattana, T. Sura, W. Chantratita, and Y. Nakamura: HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in Thai HIV-infected patients. Pharmacogenetics and Genomics, 19:139-146, 2009

979. D. N. Nikolova, N. Doganov, R. Dimitrov, K. Angelov, S.-K. Low, I. Dimova, D. Toncheva, Y. Nakamura, and H. Zembutsu: Genome-wide gene expression profiles of ovarian carcinoma: identification of molecular targets for the treatment of ovarian carcinoma. Molecular Medicine Reports, 2:365-384, 2009

980. K. Yamazaki, A. Takahashi, M Takazoe, M. Kubo, Y. Onouchi, A. Fujino, N. Kamatani, Y. Nakamura, and A. Hata: Positive association of genetic variants in the upstream region of NXT2-3 with Crohn's disease in Japanese patients. Gut, 58:228-232, 2009

981. D. Hirata, T. Yamabuki, D. Miki, T. Ito, E. Tsuchiya, M. Fujita, M. Hosokawa, K. Chayama, Y. Nakamura, and Y. Daigo: Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression. Clinical Cancer Research, 15:256-266, 2009

982. S. Dobashi, T. Katagiri, E. Hirota, S. Ashida, Y. Daigo, T. Shuin, T. Fujioka, T. Miki, and Y. Nakamura: Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. Oncology Reports, 21:305-312, 2009

983. H. Zembutsu, Y. Suzuki, A. Sasaki, T. Tsunoda, M. Okazaki, M. Yoshimoto, T. Hasegawa, K. Hirata, and Y. Nakamura: Predicting response to Docetaxel neoadjuvant chemotherapy for advanced breast cancers through genome-wide gene expression profiling. International Journal of Oncology, 34:361-370, 2009

984. Y. Nakamura: DNA variations in human and medical genetics: 25 years of my experience.

(review) Journal of Human Genetics, 54:1-8, 2009 985. K. Ozaki, H. Sato, K. Inoue, T. Tsunoda, Y. Sakata, H. Mizuno, T.-H. Lin, Y. Miyamoto, A. Aoki, Y.

Onouchi, S.-H. Sheu, S. Ikegawa, K. Odashiro, M. Nobuyoshi, S.-H. H. Juo, M. Hori, Y. Nakamura, and T. Tanaka: SNPs in BRAP associated with risk of myocardial infarction in Asian populations. Nature Genetics, 41:329-333, 2009

986. K. Kashiwaya, M. Hosokawa, H. Eguchi, H. Ohigashi, O. Ishikawa, Y. Shinomura, Y. Nakamura, and H. Nakagawa: Identification of C2orf18, Termed ANT2BP (ANT2-binding protein), as one of key molecules involved in pancreatic carcinogenesis. Cancer Science, 100:457-464, 2009

987. S. Nagayama, E. Yamada, Y. Kohno, T. Aoyama, C. Fukukawa, H. Kubo, G. Watanabe, T. Katagiri, Y. Nakamura, Y. Sakai, and J. Toguchida: Inverse correlation of the upregulation of FZD10 expression and the activation of β-catenin in synchronous colorectal tumors. Cancer Science, 100:405-412, 2009

988. K. Ueda, Y. Fukase, T. Katagiri, N. Ishikawa, S. Irie, T. Sato, H. Ito, H. Nakayama, Y. Miyagi, E. Tsuchiya, N. Kohno, M. Shiwa, Y. Nakamura, and Y. Daigo: Targeted serum glycoproteomics for the discovery of lung cancer-associated glycosylation disorders using lectin-coupled ProteinChip arrays. Proteomics, 9:2182-2192, 2009

989. The International Warfarin Pharmacogenetics Consortium: Estimation of the warfarin dose with clinical and pharmacogenetic data. New Eng. J. Med., 360:753-764, 2009

990. E.T. Betcheva, T. Mushiroda, A. Takahashi, M. Kubo, S.K. Karachanak, I.T. Zaharieva, R.V. Vazharova, I.I. Dimova, V.K. Milanova, T. Tolev, G. Kirov, M.J. Owen, M.C. O'Donovan, N. Kamatani, Y. Nakamura, and D.I. Toncheva: Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. Journal of Human Genetics, 54:98-107, 2009

991. C. Fukukawa, S. Nagayama, T. Tsunoda, J. Toguchida, Y. Nakamura, and T. Katagiri: Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma. Oncogene, 28:1110-1120, 2009

992. A. Yosifova, T. Mushiroda, D. Stoianov, R. Vazharova, I. Dimova, S. Karachanak, I. Zaharieva, V. Milanova, N. Madjirova, I. Gerdjikov, T. Tolev, S. Velkova, G. Kirov, M. J. Owen, M. C. O’Donovan, D. Toncheva, and Y. Nakamura: Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. Journal of Affective Disorders, 117:87-97, 2009

993. Y. Kamatani, S. Wattanapokayakit, H. Ochi, T. Kawaguchi, A. Takahashi, N. Hosono, M. Kubo, T. Tsunoda, N. Kamatani, H. Kumada, A. Puseenam, T. Sura, Y. Daigo, K. Chayama, W. Chantratita, Y. Nakamura, and K. Matsuda: A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nature Genetics, 41:591-595, 2009

994. K. Tamura, M. Furihata, S. Chung, M. Uemura, H. Yoshioka, T. Iiyama, S. Ashida, Y. Nasu, T. Fujioka, T. Shuin, Y. Nakamura, and H. Nakagawa: Stanniocalcin 2 (STC2) over-expression in castration-resistant prostate cancer and aggressive prostate cancer. Cancer Science, 100:914-919, 2009

995. H. Tsukada, H. Ochi, T. Maekawa, H. Abe, Y. Fujimoto, M. Tsuge, H. Takahashi, H. Kumada, N. Kamatani, Y. Nakamura, and K. Chayama: A Polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C. Gastroenterology, 136:1796-1805, 2009

996. E. M. Dunleavy, D. Roche, H. Tagami, N. Lacoste, D. Ray-Gallet, Y. Nakamura, Y. Daigo, Y. Nakatani, and G. Almouzni-Pettinotti: HJURP, a key CENP-A-partner for maintenance and deposition of CENP-A at centromeres at late telophase/G1. Cell, 137:485-497, 2009

997. M.-L. Lin, C. Fukukawa, J.-H. Park, K. Naito, K. Kijima, M. Ajiro, A. Shimo, T. Nishidate, Y. Nakamura, and T. Katagiri: Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis. Cancer Science, 100:1443-1450, 2009

998. K. Morioka, C. Tanikawa, K. Ochi, Y. Daigo, T. Katagiri, H. Kawano, H. Kawaguchi, A. Myoui, H. Yoshikawa, N. Naka, N. Araki, I. Kudawara, M. Ieguchi, K. Nakamura, Y. Nakamura, and K. Matsuda: Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Cancer Science, 100:1227-1233, 2009

999. K. Asano, T. Matsushita, J. Umeno, N. Hosono, A. Takahashi, T. Kawaguchi, T. Matsumoto, T. Matsui, Y. Kakuta, Y. Kinouchi, T. Shimosegawa, M. Hosokawa, Y. Arimura, Y. Shinomura, Y. Kiyohara, T. Tsunoda, N. Kamatani, M. Iida, Y. Nakamura, and M. Kubo: A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. Nature Genetics, 41:1325-1331, 2009

1000. S. Chung, M. Furihata, K. Tamura, M. Uemura, Y. Daigo, Y. Nasu, T. Miki, T. Shuin, T. Fujioka, Y. Nakamura, and H. Nakagawa: Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways. Oncogene, 28:2849-2859, 2009

1001. C. C. Ng, P. Y. Yew, S. M. Puah, G. Krishnan, L. F. Yap, S. H. Teo, P. V. H. Lim, S. Govindaraju, K. Ratnavelu, C. K. Sam, A. Takahashi, M. Kubo, N. Kamatani, Y. Nakamura, and T. Mushiroda: A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma. Journal of Human Genetics, 54:392-397, 2009

1002. J.-W. Kim, M. Akiyama, J.-H. Park, M.-L. Lin, A. Shimo, T. Ueki, T. Nishidate, Y. Nakamura, and

T. Katagiri: Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer. Cancer Science, 100:1468-1478, 2009

1003. M. Unoki, J. D. Kelly, D. E. Neal, B.A.J. Ponder, Y. Nakamura, and R. Hamamoto: UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer. British Journal of Cancer, 101:98-105, 2009

1004. C. Tanikawa, Y. Furukawa, N. Yoshida, H. Arakawa, Y. Nakamura, and K. Matsuda: XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway. Oncogene, 28:3081-3092, 2009

1005. K. Hotta, T. Nakamura, J. Takasaki, H. Takahashi, A. Takahashi, Y. Nakata, S. Kamohara, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, T. Funahashi, S. Miyazaki, K. Tokunaga, K. Hamaguchi, K. Tanaka, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, N. Kamatani, and Y. Nakamura: Screening of 336 single-nucleotide polymorphisms in 85 obesity-related genes revealed McKusick-Kaufman syndrome gene variants are associated with metabolic syndrome. Journal of Human Genetics, 54:230-235, 2009

1006. K. Kono, Y. Mizukami, Y. Daigo, A. Takano, K. Masuda, K. Yoshida, T. Tsunoda, Y. Kawaguchi, Y. Nakamura, and H. Fujii: Vaccination with multiple peptides derived from novel cancer-testis antigens can induce specific T-cell responses and clinical responses in advanced esophageal cancer. Cancer Science, 100:1502-1509, 2009

1007. N. Hosono, M. Kato, K. Kiyotani, T. Mushiroda, S. Takata, H. Sato, H. Amitan, Y. Tsuchiya, K. Yamazaki, T. Tsunoda, H. Zenbutsu, Y. Nakamura, and M. Kubo: CYP2D6 genotyping for functional gene-dosage analysis by allele copy number detection. Clinical Chemistry, 55:1546-1554, 2009

1008. H. Abe, H. Ochi, T. Maekawa, T. Hatakeyama, M. Tsuge, S. Kitamura, T. Kimura, D. Miki, F. Mitsui, N. Hiraga, M. Imamura, Y. Fujimoto, S. Takahashi, Y. Nakamura, H. Kumada, and K. Chayama: Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection. Hepatology Research, 39:1159-1168, 2009

1009. K. Moriwaki, K. Noda, Y. Furukawa, K. Ohshima, A. Uchiyama, T. Nakagawa, N. Taniguchi, Y. Daigo, Y. Nakamura, N. Hayashi, and E. Miyoshi: Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling. Gastroenterology, 137:188-198, 2009

1010. S. Chung, K. Tamura, M. Furihata, M. Uemura, Y. Daigo, Y. Nasu, T. Miki, T. Shuin, T. Fujioka, Y. Nakamura, and H. Nakagawa: Overexpression of the potential kinase, Serine/Threonine/Tyrosine Kinase 1(STYK1 ) in castration-resistant prostate cancer. Cancer Science, 100:2109-2114, 2009

1011. S.-K. Low, K. Kiyotani, T. Mushiroda, Y. Daigo, Y. Nakamura, and H. Zembutsu: Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients. Journal of Human Genetics, 54:564-571, 2009

1012. P.-C. Cha, T. Mushiroda, H. Zembutsu, H. Harada, N. Shinoda, S. Kawamoto, R. Shimoyama, T Nishidate, T. Furuhata, K. Sasaki, K. Hirata, and Y. Nakamura: Single nucleotide polymorphism in ABCG2 is associated with irinotecan-induced severe myelosuppression. Journal of Human Genetics, 54:572-580, 2009

1013. M. Ajiro, T. Katagiri, K. Ueda, H. Nakagawa, C. Fukukawa, M.-L. Lin, J.-H. Park, T. Nishidate, Y. Daigo, and Y. Nakamura: Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells. International Journal of Oncology, 35:673-681, 2009

1014. Y. Okada, R. Yamada, A. Suzuki, Y. Kochi, K. Shimane, K. Myouzen, M. Kubo, Y. Nakamura, and K. Yamamoto: Contribution of a Haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1. Arthritis & Rheumatism, 60:3582-3590, 2009

1015. R. Cui, Y. Kamatani, A. Takahashi, M. Usami, N. Hosono, T. Kawaguchi, T. Tsunoda, N. Kamatani, M. Kubo, Y. Nakamura, and K. Matsuda: Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. Gastroenterology, 137:1768-1775, 2009

1016. K. Tamura, A. Makino, F. Hullin-Masuda, T. Kobayashi, M. Furihata, S. Chung, S. Ashida, T. Miki, T. Fujioka, T. Shuin, Y. Nakamura, and H. Nakagawa: Novel lipogenic enzyme ELOVL7 involves in prostate cancer growth through saturated long-chain fatty acid metabolism. Cancer Research, 69:8133-8140, 2009

1017. T. Ueki, J.-H. Park, T. Nishidate, K. Kijima, K. Hirata, Y. Nakamura, and T. Katagiri: Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells. Cancer Research, 69:8752-8760, 2009

1018. H. Nakahara, N. Hosono, T. Kitayama, K. Sekiguchi, M. Kubo, A. Takahashi, Y. Nakamura, Y. Yamano, and K. Kai: Automated SNPs typing system based on the Invader assay. Legal Medicine, 11 Suppl1:S111-114, 2009

1019. C. Tanikawa, K. Ueda, H. Nakagawa, N. Yoshida, Y. Nakamura, and K. Matsuda: Regulation of protein citrullination through p53/PADI4 network in DNA damage response. Cancer Research, 69:8761-8769, 2009

1020. M. Kato, T. Kawaguchi, S. Ishikawa, T. Umeda, R. Nakamichi, M. H. Shapero, K. W. Jones, Y. Nakamura, H. Aburatani, and T. Tsunoda: Population-genetic nature of copy number variations in the human genome. Human Molecular Genetics, 19:761-773, 2009

1021. S. Omori, Y. Tanaka, M. Horikoshi, A. Takahashi, K. Hara, H. Hirose, A. Kashiwagi, K. Kaku, R. Kawamori, T. Kadowaki, Y. Nakamura, and S. Maeda: Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals. Diabetologia, 52:1554-1560, 2009

1022. T. Matsushita, M. Kubo, K.Yonemoto, T. Ninomiya, K. Ashikawa, B. Liang, J. Hata, Y. Doi, T. Kitazono, S. Ibayashi, M. Iida, Y. Kiyoharam and Y. Nakamura: Lack of association between variations of PDE4D and ischemic stroke in the Japanese population. Stroke, 40:1245-1251, 2009

1023. K. Shimane, Y. Kochi, R. Yamada, Y. Okada, A. Suzuki, A. Miyake, M. Kubo, Y. Nakamura, and K. Yamamoto: A single nucleotide polymorphism in the IRF5 promoter region is associated with susceptibility to rheumatoid arthritis in the Japanese population Annals of the Rheumatic Diseases, 68:377-383, 2009

1024. M. Tamari, M. Harada, T. Hirota, and Y. Nakamura: Host molecular defence mechanisms against Chlamydophilia pneumoniae and genetic studies of immune-response-related genes in asthma. Recent Pat Inflamm Allergy Drug Discovory, 3:17-25, 2009

1025. M. Harada, K. Obara, T. Hirota, T. Yoshimoto, Y. Hitomi, M. Sakashita, S. Doi, A. Miyatake, K. Fujita, T. Enomoto, M. Taniguchi, N. Higashi, Y. Fukutomi, K. Nakanishi, Y. Nakamura, and M. Tamari: A functional polymorphism in IL-18 is associated with severity of bronchial asthma. Am J Respir Crit Care Med, 180:1048-1055, 2009

1026. Y. Hitomi, M. Ebisawa, M. Tomikawa, T. Imai, T. Kamata, T. Hirota, M. Harada, M. Sakashita, Y. Suzuki, N. Shomojo, Y. Kohno, K. Fujita, A. Miyatake, S. Doi, T. Enomoto, M. Taniguchi, N. Higashi, Y. Nakamura, and M. Tamari: Association of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma. Journal of Allergy and Clinical Immunology, 124:779-785, 2009

1027. H. Naruse, N. Ikawa, K. Yamaguchi, Y. Nakamura, M. Arai, C. Ishioka, K. Sugano, K. Tamura, N. Tomita, N. Matsubara, T. Yoshida, Y. Moriya, and Y. Furukawa: Determination of splice-site mutations in Lynch syndrome (hereditary non-polyposis colorectal cancer) patients using functional splicing assay. Familial Cancer, 8:509-517, 2009

1028. H. Eguchi, O. Ishikawa, H. Ohigashi, H. Takahashi, M. Yano, K. Nishiyama, Y. Tomita, R. Uehara, A. Takehara, Y. Nakamura, and H. Nakagawa: Serum REG4 level is a predictive biomarker for the response to preoperative chemoradiotherapy in patients with pancreatic cancer. Pancreas, 38:791-798, 2009

1029. K. Hotta, M. Nakamura, T. Nakamura, T. Matuso, Y. Nakata, S. Kamohara, N. Miyatake, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, T. Funahashi, S. Miyazaki, K. Tokunaga, M. Kawamoto, T. Ueno, K. Hamaguchi, K. Tanaka, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, N. Kamatani, and Y. Nakamura: Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. Journal of Human Genetics, 54:727-731, 2009

1030. T. Nagao, M. Kira, M. Takahashi, J. Honda, T. Hirose, A. Tangoku, H. Zembutsu, Y. Nakamura, and M. Sasa: Serum estradiol should be monitored not only during the peri-menopausal period but also the post-menopausal period at the time of aromatase inhibitor administration. World Journal of Surgical Oncology, 7:88-92, 2009

1031. W. Satake, Y. Nakabayashi, I. Mizuta, Y. Hirota, C. Ito, M. Kubo, T. Kawaguchi, T. Tsunoda, M. Watanabe, A. Takeda, H. Tomiyama, K. Nakashima, K. Hasegawa, F. Obata, T. Yoshikawa, H. Kawakami, S. Sakoda, M. Yamamoto, N. Hattori, M. Murata, Y. Nakamura, and T. Toda: Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nature Genetics, 41:1303-1307, 2009

1032. D.P. Zabel, C.H. Andreasen, K.S. Burgdorf, E.A. Andersson, A. Sandbaek, T. Lauritzen, K. Borch-Johnsen, T. Jorgensen, S. Maeda, Y. Nakamura, H. Eiberg, O. Pederse, T. Hansen Variation in the gene encoding Kruppel-like factor 7 influences body fat: studies of 14 818 Danes. European Journal of Endocrinology, 160:603-609, 2009

1033. H. Hanaoka, T. Katagiri, C. Fukukawa, H. Yoshioka, S. Yamamoto, Y. Iida, T. Higuchi, N. Oriuchi, B. Paudyal, P. Paudyal, Y. Nakamura, and K. Endo, K: Radioimmunotherapy of solid tumors targeting a cell-surface protein, FZD10: therapeutic efficacy largely depends on radiosensitivity. Annals of Nuclear Medicine, 23:479-485, 2009

1034. M. Tamari, M. Harada, T. Hirota, and Y. Nakamura: Host molecular defense mechanisms against Chlamydophila pneumoniae and genetic studies of immune-response-related genes in asthma. Recent Patents on Inflammation & Allergy Drug Discovery, 3:17-25, 2009

1035. A. Takano, N. Ishikawa, R. Nishino, K. Masuda, W. Yasui, K. Inai, H. Nishimura, H. Ito, H. Nakayama, Y. Miyagi, E. Tsuchiya, N. Kohno, Y. Nakamura, and Y. Daigo: Identification of Nectin-4 oncoprotein as a diagnostic and therapeutic target for lung aancer. Cancer Research, 69:6694-6703, 2009

1036. Y. Kochi, K. Myouzen, R. Yamada, A. Suzuki, T. Kurosaki, Y. Nakamura, and K. Yamamoto: FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling. Journal of Immunology, 183:5502-5510, 2009

1037. K. Nishimoto, Y. Kochi, K. Ikari, K. Yamamoto, A. Suzuki, K. Shimane, Y. Nakamura, K. Yano, N. Iikuni, S. Tsukahara, N. Kamatani, H. Okamoto, H. Kaneko, Y. Kawaguchi, M. Hara, Y. Toyama, T. Horiuchi, K. Tao, K. Yasumoto, D. Hamada, N. Yasui, H. Inoue, M. Itakura, H. Yamanaka, and S. Momohara: Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese. Annals of the Rheumatic Diseases, 69:368-373, 2010

1038. K. Kiyotani, T. Mushiroda, C. K. Imamura, N. Hosono, T. Tsunoda, M. Kubo, Y. Tanigawara, D.A. Flockhart, Z. Desta, T.C. Skaar, F. Aki, K. Hirata, Y. Takatsuka, M. Okazaki, S. Ohsumi, T. Yamakawa, M. Sasa, Y. Nakamura, and H. Zembutsu: Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients. Journal of Clinical Oncology, 28:1287-1293, 2010

1039. N. Sato, J. Koinuma, M. Fujita, M. Hosokawa, T. Ito, E. Tsuchiya, S. Kondo, Y. Nakamura, and Y. Daigo: Activation of WD repeat and High-mobility group box DNA binding protein 1 in pulmonary and esophageal carcinogenesis. Clinical Cancer Research, 16:226-239, 2010

1040. W. Wangsomboonsiri, S. Mahasirimongkol, S. Chantarangsu, S. Kiertiburanakul, A. Charoenyingwattana, S. Komindr, C. Thongnak, T. Mushiroda, Y. Nakamura, W. Chantratita, and S. Sungkanuparph: Association between HLA-B*4001 and lipodystrophy among HIV-infected patients from Thailand who received a stavudine-containing antiretroviral regimen. Clinical Infectious Diseases, 50:597-604, 2010

1041. M. Miyazawa, R. Ohsawa, T. Tsunoda, S. Hirono, M. Kawai, M. Tani, Y. Nakamura, and H. Yamaue: Phase I clinical trial using peptide vaccine for human vascular endothelial growth factor receptor 2 in combination with gemcitabine for patients with advanced pancreatic cancer. Cancer Science, 101:433-439, 2010

1042. M. Nuinoon, W. Makarasara, T. Mushiroda, I. Setianingsih, P. A. Wahidiyat, O. Sripichai, N. Kumasaka, A. Takahashi, S. Svasti, T. Munkongdee, S. Mahasirimongkol, C. Peerapittayamongkol, V. Viprakasit, N. Kamatani, P. Winichagoon, M. Kubo, Y. Nakamura, and S. Fucharoen: A genome-wide association identified the common genetic variants influence disease severity in β0-thalassemia/hemoglobin E. Human Genetics, 127:303-314, 2010

1043. H. Nakahara, K. Sekiguchi, N. Hosono, M. Kubo, A. Takahashi, Y. Nakamura, and K. Kasai: Criterion values for multiplex SNP genotyping by the Invader assay. Forensic Science International: Genetics, 4:130-136, 2010

1044. J.-H. Park, T. Nishidate, Y. Nakamura, and T. Katagiri: Critical roles of T-LAK cell-originated protein kinase in cytokinesis. Cancer Science, 101:403-411, 2010

1045. N. Sato, J. Koinuma, T. Ito, E. Tsuchiya, S. Kondo, Y. Nakamura, and Y. Daogo: Activation of an oncogenic TBC1D7 (TBC1 Domain Family, Member 7) protein in pulmonary carcinogenesis. Genes Chromosomes and Cancer, 49:353-367, 2010

1046. Y. Kamatani, K. Matsuda, M. Kubo, N. Hosono, Y. Daigo, Y. Nakamura, and N. Kamatani: Genome-wide association study of hematological and biochemical traits in a Japanise population. Nature Genetics, 42:210-215, 2010

1047. M. Inoue, S. Senju, S. Hirata, Y. Ikuta, Y. Hayashida, A. Irie, M. Harao, K. Imai, Y. Tomita, T. Tsunoda, Y. Furukawa, T. Ito, Y. Nakamura, H. Baba, and Y. Nishimura: Identification of SPARC as a candidate target antigen for immunotherapy of various cancers. International Journal of Cancer, 127:1393-1403, 2010

1048. S. Maeda, M. Kobayashi, S. Araki, T. Babazono, B. I. Freedman, M. A. Bostrom, J. N. Cooke, M. Toyoda, T. Umezono, L. Tarnow, T. Hansen, P. Gaede, A. Jorsal, D. P K Ng, M. Ikeda, T. Yanagimoto, T. Tsunoda, H. Unoki, K. Kawai, M. Imanishi, D. Suzuki, H. D. Shin, K. S. Park, A. Kashiwagi, Y. Iwamoto, K. Kaku, R. Kawamori, H.-H. Parving, D. W. Bowden, O. Pedersen, and Y. Nakamura: A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 Diabetes. PLoS Genetics, 6:e1000842, 2010

1049. J.-H. Park, T. Nishidate, K. Kijima, T. Ohashi, K. Takegawa, T. Fujikane, K. Hirata, Y. Nakamura, and T. Katagiri: Critical roles of mucin1 glycosylation by transactivated polypeptide N-acetylgalactosaminyltransferase 6 in mammary carcinogenesis. Cancer Research, 70:2759-2769, 2010

1050. H. Mototani, A. Iida, Y. Nakamura, and S. Ikegawa: Identification of sequence polymorphisms in CALM2 and analysis of association with hip osteoarthritis in a Japanese population. Journal of Bone and Mineral Metabolism, 28:547-553, 2010

1051. N.J. Prescott, K.M. Dominy, M. Kubo, C.M. Lewis, S.A. Fisher, R. Redon, N. Huang, B.E. Stranger, K. Blaszczyk, B. Hudspith, G. Parkes, N. Hosono, K. Yamazaki, C.M. Onnie, A. Forbes, E.T. Dermitzakis, Y. Nakamura, J.C. Mansfield, J. Sanderson, M.E. Hurles, R.G. Roberts, and C.G. Mathew: Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease. Human Molecular Genetics, 19:1828-1839, 2010

1052. S. Hayami, M. Yoshimatsu, A. Veerakumarasivam, M. Unoki, Y. Iwai, T. Tsunoda, H.I. Field, J.D.

Kelly, D.E. Neal, H. Yamaue, B.A.J. Ponder, Y. Nakamura, and R. Hamamoto: Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Molecular Cancer, 9:59-73, 2010

1053. R. Takayama, H. Nakagawa, A. Sawaki, N. Mizuno, H. Kawai, M. Tajika, Y. Yatabe, K. Matsuo, R. Uehara, K. Ono, Y. Nakamura, and K. Yamao: Serum tumor antigen REG4 a diagnostic biomarker in pancreatic ductal adenocarcinoma. Journal of Gastroenterology, 45:52-59, 2010

1054. K. Yasuno, K. Bilguvar, P. Bijlenga, S.-K. Low, B. Krischek, G. Auburger, M. Simon, D. Krex, Z. Arlier, N. Nayak, Y.M. Ruigrok, M. Niemela, A. Tajima, M. Fraunberg, T. Doczi, F. Wirjatijasa, A. Hata, J. Blasco, A. Oszvald, H. Kasuya, G. Zilani, B. Schoch, P. Singh, C. Stuer, R. Risselada, J. Beck, S. Teresa, F. Ricciardi, A. Aromaa, T. Illig, S. Schreiber, C.M. van Duijn, L.H. van den Berg, C. Perret, C. Proust, C. Roder, A.K. Ozturk, E. Gaal, D. Berg, C. Geisen, C.M. Friedrich, P. Summers, A.F. Frangi, M.W. State, H.E. Wichmann, M.M.B. Breteler, C. Wijmenga, S. Mane, L. Peltonen, V. Elio, M.CJM. Sturkenboom, P. Lawford, J. Byrne, J. Macho, I.E. Sandalcioglu, B. Meyer, A. Raabe, D. Rufenacht, J.E. Jaaskelainen, J. Hernesniemi, G.J.E. Rinkel, H. Zembutsu, I. Inoue, A. Palotie, F. Cambien, Y. Nakamura, R.P. Lifton, and M. Gunel: Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nature Genetics, 42:420-425, 2010

1055. M. Nakajima, A. Takahashi, I. Kou, C. Rodriguez-Fontenla, J.J. Gomez-Reino, T. Furuichi, J. Dai, A. Sudo, A. Uchida, N. Fukui, M. Kubo, N. Kamatani, T. Tsunoda, K.N. Malizos, A. Tsezou, A. Gonzalez, Y. Nakamura, and S. Ikegawa: New sequence variants in HLA class Ⅱ/Ⅲ region associated with susceptibility to knee osteoarthritis identified by genome-wide association study. PLoS ONE, 5:e9723, 2010

1056. S. Hayami, J. D. Kelly, H.-S. Cho, M. Yoshimatsu, M. Unoki, T. Tsunoda, H.I. Field, D.E. Neal, H. Yamaue, B.A.J. Ponder, Y. Nakamura, and R. Hamamoto: Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. International Journal of Cancer, 128:574-586, 2010

1057. The International Cancer Genome Consortium: International network of cancer genome projects. Nature, 464:993-998, 2010

1058. K. Yamaguchi, M. Sakai, T. Shimokawa, Y. Yamada, Y. Nakamura, and Y. Furukawa: C20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer. British Journal of Cancer, 102:325-331, 2010

1059. K. Kashiwaya, H. Nakagawa, M. Hosokawa, Y. Mochizuki, L. Piao, S. Chung, K. Ueda, R. Hamamoto, H. Eguchi, H. Ohigashi, O. Ishikawa, C. Janke, Y. Shinomura, and Y. Nakamura: Involvement of tublin tyrosine ligase-like family member 4 polyglutamylase in PELP1 polyglutamylation and chromatin remodeling in pancreatic cancer cells. Cancer Research, 70:4024-4033, 2010

1060. N. Akuta, F. Suzuki, M. Hirakawa, Y. Kawamura, H. Yatsuji, H. Sezaki, Y. Suzuki, T. Hosaka, M. Kobayashi, M. Kobayashi, S. Saitoh, Y. Arase, K. Ikeda, K. Chayama, Y. Nakamura, and H. Kumada: Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin. Hepatology, 52:421-429, 2010

1061. N. Phasukkijwatana, B. Kunhapan, J. Stankovich, W. L. Chuenkongkaew, R. Thomson, T. Thornton, M. Bahlo, T. Mushiroda, Y. Nakamura, S. Mahasirimongkol, A. W. Tun, C. Srisawat, C. Limwongse, C. Peerapittayamongkol, T. Sura, W. Suthammarak, and P. Lertrit: Genome-wide linkage scan and association study of PARL to the expression of LHON families in Thailand. Human Genetics, 128:39-49, 2010

1062. A. Ramamoorthy, D. A. Flockharta, N. Hosono, M. Kubo, Y. Nakamura, and T. C. Skaar: Differential quantification of CYP2D6 gene copy number by four different quantitative real-time PCR assays. Pharmacogenetics and Genomics, 20:451-454, 2010

1063. Y. Kochi, Y. Okada, A. Suzuki, K. Ikari, C. Terao, A. Takahashi, K. Yamazaki, N. Hosono, K. Myouzen, T. Tsunoda, N. Kamatani, T. Furuichi, S. Ikegawa, K. Ohmura, T. Mimori, F. Matsuda, T. Iwamoto, S. Momohara, H. Yamanaka, R. Yamada, M. Kubo, Y. Nakamura, and K. Yamamoto: A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nature Genetics, 42:515-519, 2010

1064. K. Kiyotani, T. Mushiroda, N. Hosono, T. Tsunoda, M. Kubo, F. Aki, Y. Okazaki, K. Hirata, Y. Takatsuka, M. Okazaki, S. Ohsumi, T. Yamakawa, M. Sasa, Y. Nakamura, and H. Zembutsu: Lessons for pharmacogenomics studies; association study between CYP2D6 genotype and tamoxifen response. Pharmacogenetics and Genomics, 20:565-568, 2010

1065. H. Abe, H. Ochi, T. Maekawa. C.N. Hayes, M. Tsuge. D. Miki, F. Mitsui, N. Hiraga, M. Imamura, S. Takahashi, W. Ohishi, K. Arihiro, M. Kubo, Y. Nakamura, and K. Chayama: A common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients. Journal of Hepatology, 53:439-443, 2010

1066. C. Tanikawa, Y. Nakamura, and K. Matsuda: Crosstalk of EDA-A2/XEDAR in the p53 signaling pathway. Molecular Cancer Research, 8:855-863, 2010

1067. Y. Onouchi, K. Ozaki, J.C. Buns, C. Shimizu, H. Hamada, T. Honda, M. Terai, A. Honda, T. Takeuchi, S. Shibuta, T. Suenaga, H. Suzuki, K. Higashi, K. Yasukawa, Y. Suzuki, K. Sasago, Y.

Kemmotsu, S. Takatsuki, T. Saji, T. Yoshikawa, T. Nagai, K. Hamamoto, F. Kishi, K. Ouchi, Y. Sato, J. W. Newburger, A. L. Baker, S. T. Shulman, A. H. Rowley, M. Yashiro, Y. Nakamura, K. Wakui, Y. Fukushima, A. Fujino, T. Tsunoda, T. Kawasaki, A. Hata, Y. Nakamura, and T. Tanaka: Common variants in CASP3 confer susceptibility to Kawasaki disease. Human Molecular Genetics, 19:2898-2906, 2010

1068. K. Yokomine, S. Senju, T. Nakatsura, A. Irie, Y. Hayashida, Y. Ikuta, M. Harao, K. Imai, H. Baba, H. Iwase, H. Nomori, K. Takahashi, Y. Daigo, T. Tsunoda, Y. Nakamura, Y. Sasaki, and Y. Nishimura: The forkhead box M1 transcription factor as a candidate of target for anti-cancer immunotherapy. International Journal of Cancer, 126:2153-2163, 2010

1069. M.-H. Nguyen, J. Koinuma, K. Ueda, T. Ito, E. Tsuchiya, Y. Nakamura, and Y. Daigo: Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis. Cancer Research, 70:5337-5347, 2010

1070. C. Fukukawa, K. Ueda, T. Nishidate, T. Katagiri, and Y. Nakamura: Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells. Genes Chromosomes and Cancer, 49:861-872, 2010

1071. N. Sato, T. Yamabuki, A. Takano, J. Koinuma, M. Aragaki, K. Masuda, N. Ishikawa, N. Kohno, H. Ito, M. Miyamoto, H. Nakayama, Y. Miyagi, E. Tsuchiya, S. Kondo, Y. Nakamura, and Y. Daigo: Wnt Inhibitor dickkopf-1 as a target for passive cancer immunotherapy. Cancer Research, 70:5326-5336, 2010

1072. Y. Harada, M. Kanehira, Y. Fujisawa, R. Takata, T. Shuin, T. Miki, T. Fujioka, Y. Nakamura, and T. Katagiri: Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells. Cancer Research, 70:5829-5839, 2010

1073. S. Uno, H. Zembutsu, A. Hirasawa, A. Takahashi, M. Kubo, T. Akahane, D. Aoki, N. Kamatani, K. Hirata, and Y. Nakamura: A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese. Nature Genetics, 42:707-710, 2010

1074. M. Uemura, S. Honma, S. Chung, R. Takata, M. Furihata, K. Nishimura, N. Nonomura, Y. Nasu, T. Miki, T. Shuin, T. Fujioka, A. Okuyama, Y. Nakamura, and H. Nakagawa: 5αDH-DOC (5α-dihydro-deoxycorticosterone) activates androgen receptor in castration-resistant prostate cancer. Cancer Science, 101:1897-1904, 2010

1075. H. Akaza, K. Kawai, T. Tsukamoto, T. Fujioka, Y. Tomita, T. Kitamura, S. Ozono, T. Miki, S. Naito, H. Zembutsu, and Y. Nakamura: Successful outcomes using combination therapy of interleukin-2 and interferon-α for renal cell carcinoma patients with lung metastasis. Japanese Journal of Clinical Oncology, 40:684-689, 2010

1076. K. Ueda, S. Takami, N. Saichi, Y. Daigo, N. Ishikawa, N. Kohno, M. Katsumata, A. Yamane, M. Ota, T.-A. Sato, Y. Nakamura, and H. Nakagawa: Development of serum glycoproteomic profiling technique; simultaneous identification of glycosylation sites and site-specific quantification of glycan structure changes. Molecular and Cellular Proteomics, 9:1819-1828, 2010

1077. J.N. Ingle, D.J. Schaid, P.E. Goss, M. Liu, T. Mushiroda, J.-A.W. Chapman, M. Kubo, G.D. Jenkins, A. Batzler, L. Shepherd, J. Pater, L. Wang, M.J. Ellis, V. Stearns, D.C. Rohrer, M.P. Goetz, K.I. Pritchard, D.A. Flockhart, Y. Nakamura, and R.M. Weinshilboum: Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors. Journal of Clinical Oncology, 28:4674-4682, 2010

1078. Y. Okada, Y. Kamatani, A. Takahashi, K. Matsuda, N. Hosono, H. Ohmiya, Y. Daigo, K. Yamamoto, M. Kubo, Y. Nakamura, and N. Kamatani: Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count. Human Molecular Genetics, 19:2079-2085, 2010

1079. Y. Okada, Y. Kamatani, A. Takahashi, K. Matsuda, N. Hosono, H. Ohmiya, Y. Daigo, K. Yamamoto, M. Kubo, Y. Nakamura, and N. Kamantani: A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. Human Molecular Genetics, 19:2303-2312, 2010

1080. R. Takata, S. Akamatsu, M. Kubo, A. Takahashi, N. Hosono, T. Kawaguchi, T. Tsunoda, J. Inazawa, N. Kamatani, O. Ogawa, T. Fujioka, Y. Nakamura, and H. Nakagawa: Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Nature Genetics, 42:751-754, 2010

1081. J.-W. Kim, C. Fukukawa, K. Ueda, T. Nishidate, T. Katagiri, and Y. Nakamura: Involvement of C12orf32 overexpression in breast carcinogenesis. International Journal of Oncology, 37:861-867, 2010

1082. M. Nakashima, S. Chung, A. Takahashi, N. Kamatani, T. Kawaguchi, T. Tsunoda, N. Hosono, M. Kubo, Y. Nakamura, and H. Zembutsu: A genome-wide association study identifies four susceptibility loci for keloid in Japanese population. Nature Genetics, 42:768-771, 2010

1083. A. Iida, T. Kamei, M. Sano, S. Oshima, T. Tokuda, Y. Nakamura, and S. Ikegawa: Large-scale screening of TARDBP mutations in amyotrophic lateral sclerosis in Japanese. Neurobiology of Aging, Jul 30. [Epub ahead of print]:, 2010

1084. S.-K. Low, A. Kuchiba, H. Zembutsu, A. Saito, A. Takahashi, M. Kubo, Y. Daigo, N. Kamatani, S. Chiku, H. Totsuka, S. Ohnami, H. Hirose, K. Shimada, T. Okusaki, T. Yoshida, Y. Nakamura, and H. Sakamoto: Genome-wide association study of pancreatic cancer in Japanese population.

PLoS ONE, 5:e11824, 2010 1085. H. Ochi, T. Maekawa, H. Abe, Y. Hayashida, R. Nakano, M. Kubo, T. Tsunoda, C.N. Hayes, H.

Kumada, Y. Nakamura, and K. Chayama: ITPA polymorphism affects ribavirin-induced anemia and outcome of therapy - a genome-wide study of Japanese HCV patients. Gastroenterology, 139:1190-1197, 2010

1086. O. Mizumori, H. Zembutsu, Y. Kato, T. Tsunoda, F. Miya, T. Morizono, T. Tsukamoto, T. Fujioka, Y. Tomita, T. Kitamura, S. Ozono, T. Miki, S. Naito, H. Akaza, and Y. Nakamura: Identification of a set of genes associated with response to interleukin-2 and interferon-α combination therapy for renal cell carcinoma through genome-wide gene expression profiling. Experimental and Therapeutic Medicine, 1:955-961, 2010

1087. M. Ajiro, T. Nishidate, T. Katagiri, and Y. Nakamura: Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis. International Journal of Oncology, 37:1085-1093, 2010

1088. D. Miki, M. Kubo, A. Takahashi, K.-A. Yoon, J. Kim, G.-K. Lee, J.I. Zo, J.S. Lee, N. Hosono, T. Morizono, T. Tsunoda, N. Kamatani, K. Chayama, T. Takahashi, J. Inazawa, Y. Nakamura, and Y. Daigo: Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean population. Nature Genetics, 42:893-896, 2010

1089. K. Myouzen, Y. Kochi, K. Shimane, K. Fujio, T. Okamura, Y. Okada, A. Suzuki, T. Atsumi, S. Ito, K. Takada, A. Mimori, S. Ikegawa, R. Yamada, Y. Nakamura, and K. Yamamoto: Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus. Human Molecular Genetics, 19:2313-2320, 2010

1090. T. Yamauchi, K. Hara, S. Maeda, K. Yasuda, A. Takahashi, M. Horikoshi, M. Nakamura, H. Fujita, N. Grarup, S Cauchi, D. Ng, R. Ma, T. Tsunoda, M. Kubo, H. Watada, H. Maegawa, M. Okada-Iwabu, M. Iwabu, N. Shojima, H.D. Shin, G. Andersen, D.R. Witte, T. Jorgensen, T. Lauritzen, A. Sandbaek, T. Hansen, T. Ohshige, S. Omori, I. Saito, K. Kaku, H. Hirose, W.-Y. So, D. Beury, J. Chan, K.S. Park, S. Tai, C. Ito, Y. Tanaka, A. Kashiwagi, R. Kawamori, M. Kasuga, P. Froguel, O. Pedersen, N. Kamatani, Y. Nakamura, and T. Kadowaki: A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nature Genetics, 42:864-868, 2010

1091. S. Akamatsu, R. Takata, K. Ashikawa, N. Hosono, N. Kamatani, T. Fujioka, O Ogawa, M. Kubo, Y. Nakamura, and H. Nakagawa: A functional variant in NKX3.1 associated with prostate cancer susceptibility down-regulates NKX3.1 expression. Human Molecular Genetics, 19:4265-4272, 2010

1092. Y. Okada, A. Suzuki, R. Yamada, Y. Kochi, K. Shimane, K. Myouzen, M. Kubo, Y. Nakamura, and K. Yamamoto: HLA-DRB1*0901 lowers anti-cyclic citrullinated peptide antibody levels in Japanese patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 69:1569-1570, 2010

1093. P.-C. Cha, T. Mushiroda, A. Takahashi, M. Kubo, S. Minami, N. Kamatani, and Y. Nakamura: Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese. Human Molecular Genetics, 19:4735-4744, 2010

1094. S. Maeda, S. Araki, T. Babazono, M. Toyoda, T. Umezono, K. Kawai, M. Imanishi, T. Uzu, H. Watada, D. Suzuki, A. Kashiwagi, Y. Iwamoto, K. Kaku, R. Kawamori, and Y. Nakamura: Replication study for the association between four loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. Diabetes, 59:2075-2079, 2010

1095. N. Kumasaka, Y. Yamaguchi-Kabata, A. Takahashi, M. Kubo, Y. Nakamura, and N. Kamatani: Establishment of a standardized system to perform population structure analyses with limited sample size or with different sets of SNP genotypes. Journal of Human Genetics, 55:525-533, 2010

1096. N. Stefanou, V. Papanikolaou, Y. Furukawa, Y. Nakamura, and A. Tsezou: Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase. BMC Cancer, 10:442, 2010

1097. Y. Yamaguchi-Kabata, T. Tsunoda, A. Takahashi, N. Hosono, M. Kubo, Y. Nakamura, and N. Kamatani: Making a haplotype catalog with estimated frequencies based on SNP homozygotes. Journal of Human Genetics, 55:500-506, 2010

1098. A. Fujimoto, H. Nakagawa, N. Hosono, K. Nakano, T. Abe, K.A. Boroevich, M. Nagasaki, R. Yamaguchi, T. Shibuya, M. Kubo, S. Miyano, Y. Nakamura, and T. Tsunoda: Whole-genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing. Nature Genetics, 42:931-936, 2010

1099. K.-A. Yoon, J.H. Park, J. Han, S. Park, G.K. Lee, J.-Y. Han, J.I. Zo, J. Kim, J.E. Lee, A. Takahashi, M. Kubo, Y. Nakamura, and J.S. Lee: A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. Human Molecular Genetics, 19:4948-4954, 2010

1100. T. Matsushita, K. Ashikawa, K. Yonemoto, Y. Hirakawa, J. Hata, H. Amitani, Y. Doi, T. Ninomiya, T. Kitazono, S. Ibayashi, M. Iida, Y. Nakamura, Y. Kiyohara, and M. Kubo: Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke. Human Molecular Genetics, 19:1137-1146,

2010 1101. T. Matsushita, J. Umeno, Y. Hirakawa, K. Yonemoto, K. Ashikawa, H. Amitani, T, Ninomiya, J.

Hata, Y. Doi, T. Kitazono, M. Iida, Y. Nakamura, Y. Kiyohara, and M. Kubo: Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population. Journal of Human Genetics, 55:473-476, 2010

1102. I.P.M. Tomlinson, M. Dunlop, H. Campbell, B. Zanke, S. Gallinger, T. Hudson, T. Koessler, P.D. Pharoah, I. Niittyma¨kix, S. Tuupanenx, L.A. Aaltonen, K. Hemminki, A. Lindblom, A. Fo¨ rsti, O. Sieber, L. Lipton, T. van Wezel, H. Morreau, J.T. Wijnen, P. Devilee, K. Matsuda, Y. Nakamura, S. Castellvı´-Bel, C. Ruiz-Ponte, A. Castells, A. Carracedo, J.W.C. Ho, P. Sham, R.M.W. Hofstra, P. Vodicka, H. Brenner, J. Hampe, C. Schafmayer, J. Tepel, S. Schreiber, H. Vo¨ lzke, M.M. Lerch, C.A. Schmidt, S. Buch, V. Moreno, C.M. Villanueva, P. Peterlongo, P. Radice, M.M. Echeverry, A. Velez, L. Carvajal-Carmona, R. Scott, S. Penegar, P. Broderick, A. Tenesa, and R.S. Houlston: COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer. British Journal of Cancer, 102:447-454, 2010

1103. M. Unoki, Y. Daigo, J. Koinuma, E. Tsuchiya, R. Hamamoto, and Y. Nakamura: UHRF1 is a novel diagnostic marker of lung cancer. British Journal of Cancer, 103:217-222, 2010

1104. N. Hosono, S. Chantarangsu, K. Kiyotani, S. Takata, Y. Tsuchiya, S. Mahasirimongkol, W. Chantratita, T. Mushiroda, Y. Nakamura, and M. Kubo: Development of new HLA-B*3505 genotyping method using Invader assay Pharmacogenetics and Genomics, 10:630-633, 2010

1105. N. Kumasaka, Y. Nakamura, and N. Kamatani: The textile plot: A new linkage disequilibrium display of multiple-single nucleotide polymorphism genotype data. Plos ONE, 5:e10207, 2010

1106. K. Shimane, Y. Kochi, T. Horita, K. Ikari, H. Amano, M. Hirakata, A. Okamoto, R. Yamada, K. Myouzen, A. Suzuki, M. Kubo, T. Atsumi, T. Koike, Y. Takasaki, S. Momohara, H. Yamanaka, Y. Nakamura, K. Yamamoto: The Association of a Nonsynonymous Single-Nucleotide Polymorphism in TNFAIP3 With Systemic Lupus Erythematosus and Rheumatoid Arthritis in the Japanese Population. Arthritis & Rheumatism, 62:574-579, 2010

1107. M. Sakashita, T. Hirota, M. Harada, R. Nakamichi, T. Tsunoda, Y. Osawa, A. Kojima, M. Okamoto, D. Suzuki, S. Kubo, Y. Imoto, Y. Nakamura, M. Tamari, and S. Fujieda: Prevalence of allergic rhinitis and sensitization to common aeroallergens in a Japanese population. International Archives of Allergy and Immunology, 151:255-261, 2010

1108. H. Koriyama, H. Nakagami, T. Katsuya, K. Sugimoto, H. Yamashita, Y. Takami, S. Maeda, M. Kubo, A. Takahashi, Y. Nakamura, T. Ogihara, H. Rakugi, Y. Kaneda, R. Morishita: Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population. Journal of Atherosclerosis and Thrombosis, 17:1054-1062, 2010

1109. T. Seo, R. Konda, J. Sugimura, K. Iwasaki, Y. Nakamura, and T. Fujioka: Expression of hypoxia-inducible protein 2 in renal cell carcinoma: A promising candidate for molecular targeting therapy. Oncology Letters, 1:697-701, 2010

1110. Y. Kobayashi, Y. Niwa, M. Tajika, H. Kawai, S. Kondo, K. Hara, N. Mizuno, S. Hijioka, A. Sawaki, K. Matsuo, H. Nakagawa, Y. Nakamura, and K. Yamao: Serum tumor antigen REG4 as a useful diagnostic biomarker in gastric cancer. Hepato-gastroenterology, 58:1631-1634, 2010

1111. K. Hotta, M. Nakamura, T. Nakamura, T. Matsuo, Y. Nakata, S. Kamohara, N. Miyatake, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, M. Yoneda, A. Nakajima, T. Funahashi, S. Miyazaki, K. Tokunaga, M. Kawamoto, H. Masuzaki, T. Ueno, K. Hamaguchi, K. Tanaka, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, Y. Nakamura, and Kamatani: Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population. Journal of Human Genetics, 55:738-742, 2010

1112. T. Ohshige, Y. Tanaka, S. Araki. T. Babazono, M. Toyoda, T. Umezono, H. Watada, D. Suzuki, Y. Iwamoto, R. Kawamori, Y. Nakamura and S. Maeda: A single nucleotide polymorphism in KCNQ1 is associated with susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. Diabetes Care, 33:842-846, 2010

1113. H. Akaza, T. Tsukamoto, T. Fujioka, Y. Tomita, T. Kitamura, S. Ozono, T. Miki, S. Naito, H. Zembutsu, and Y. Nakamura: Combined immunotherapy with low-dose IL-2 plus IFN-alpha for metastatic renal cell carcinoma: survival benefit for selected patients with lung metastasis and serum sodium level. Japanese Journal of Clinical Oncology, 41:1023-1030, 2011

1114. O.L.J. Peerbooms, J. van Os, M. Drukker, G. Kenis, L. Hoogveld, MTHFR in Psychiatry Group, M. de Hert, P. Delespaul, R. van Winkel, and B.P.F. Rutten: Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: A combined analysis of independent samples American Journal of Medical Genetics, 156:10.1002/ajmg.b.31160 , 2011

1115. H.-S. Cho, T. Suzuki, N. Dohmae, S. Hayami, M. Unoki, M. Yoshimatsu, G. Toyokowa, M. Takawa, T. Chen, J. K. Kurash, H.I. Field, B.A.J. Ponder, Y. Nakamura, and R. Hamamoto: Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells. Cancer Research, 71:655-660, 2011

1116. R. Cui, Y. Okada, S.G. Jang, J.L. Ku, J.G. Park, Y. Kamatani, N. Hosono, T. Tsunoda, V. Kumar, C. Tanikawa, N. Kamatani, R. Yamada, M. Kubo, Y. Nakamura, and K. Matsuda: Common variant in 6q26-q27 is associated with distal colon cancer in Asian population. Gut, 60:799-805, 2011

1117. K. Imai, S. Hirata, A. Irie, S. Senju, Y. Ikuta, K. Yokomine, M. Harao, M. Inoue, Y. Tomita, T. Tsunoda, H. Nakagawa, Y. Nakamura, H. Baba, and Y. Nishimura: Identification of HLA-A2-restricted CTL epitopes of a novel tumor-associated antigen, KIF20A, overexpressed in pancreatic cancer. British Journal of Cancer, 104:300-307, 2011

1118. A. Iida, N. Hosono, M. Sano, T. Kamei, S. Oshima, T. Tokuda, M. Kubo, Y. Nakamura, and S. Ikegawa: Optineurin mutations in Japanese amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery & Psychiatry, Jan 8. [Epub ahead of print]:, 2011

1119. T. Ozeki, T. Mushiroda, A. Yowang, A. Takahashi, M. Kubo, Y. Shirakata, Z. Ikezawa, M. Iijima, T. Shiohara, K. Hashimoto, N. Kamatani, and Y. Nakamura: Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population. Human Molecular Genetics, 20:1034-1041, 2011

1120. Y. Fujimoto, H. Ochi, T. Maekawa, H. Abe, C.N. Hayes, H. Kumada, Y. Nakamura, and K. Chayama: A single nucleotide polymorphism in activated cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients. Journal of Hepatology, 54:629-639, 2011

1121. Y. Hashimoto, H. Ochi, H. Abe, Y. Hayashida, M. Tsuge, F. Mitsui, N. Hiraga, M. Imamura, S. Takahashi, C.N. Hayes, W. Ohishi, M. Kubo, T. Tsunoda, N. Kamatani, Y. Nakamura, and K. Chayama: Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b. Journal of Medical Virology, 83:981-988, 2011

1122. F. Suzuki, Y. Suzuki, N. Akuta, H. Sezaki, M. Hirakawa, Y. Kawamura, T. Hosaka, M. Kobayashi, S. Saito, Y. Arase, K. Ikeda, M. Kobayashi, K. Chayama, N. Kamatani, Y. Nakamura, Y. Miyakawa, and H. Kumada: Influence of ITPA polymorphism on decreases of hemoglobin during treatment with pegylated IFN, ribavirin and telaprevir. Hepatology, 53:415-421, 2011

1123. T. Kawaoka , C.N. Hayes, W. Ohishi, H. Ochi, T. Maekawa, H. Abe, M. Tsuge, F. Mitsui, N. Hiraga, M. Imamura, S. Tkakahashi, M. Kubo, T. Tsunoda, Y. Nakamura, H. Kumada, and K. Chayama: Predictive value of IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b. Journal of Hepatology, 54:408-414, 2011

1124. A. Aoki, K. Ozaki, H. Sato, A. Takahashi, M. Kubo, Y. Sakata, Y. Onouchi, T. Kawaguchi, T.-H. Lin, H. Takano, M. Yasutake, P.-C. Hsu, S. Ikegawa, N. Kamatani, T. Tsunoda, S.-H. H. Juo, M. Hori, I. Komuro, K. Mizuno, Y. Nakamura, and T. Tanaka: SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population. Journal of Human Genetics, 56:47-51, 2011

1125. M. Yoshimatsu, G. Toyokawa, S. Hayami, M. Unoki, T. Tsunoda, H.I. Field, J.D. Kelly, D.E. Neal, Y. Maehara, B.A.J. Ponder, Y. Nakamura, and R. Hamamoto: Dysregulation of PRMT1 and PRMT6, type I arginine methyltransferases, is involved in various types of human cancers. International Journal of Cancer, 128:562-573, 2011

1126. C.N. Hayes, M. Kobayashi, N. Akuta, F. Suzuki, H. Kumada, H. Abe, D. Miki, M. Imamura, H. Ochi, N. Kamatani, Y. Nakamura, and K. Chayama: HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy. Gut, 60:261-267, 2011

1127. P. Saetre, M. Vares, T. Werge, O.A. Andreassen, T. Arinami, H. Ishiguro, S. Nanko, E.C. Tan, D. H. Han, J. Roffman, J.-W. Muntjewerff, P.P. Jagodzinski, B. Kempisty, J. Hauser, E. Vilella, E. Betcheva, Y. Nakamura, B. Regland, I. Agartz, H. Hall, L. Terenius, and E.G. Jönsson: Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: a combined analysis of independent samples. Neuropsychiatric Genetics, 156:215-224, 2011

1128. S. Chung, H. Nakagawa, M. Uemura, L. Piao, K. Ashikawa, N. Hosono, R. Takata, S. Akamatsu, T. Kawaguchi, T. Morizono, T. Tsunoda, Y. Daigo, K. Matsuda, N. Kamatani, Y. Nakamura, and M. Kubo: Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility. Cancer Science, 102:245-252, 2011

1129. L. Piao, H. Nakagawa, K. Ueda, S. Chung, K. Kashiwaya, H. Eguchi, H. Ohigashi, O. Ishikawa, Y. Daigo, K. Matsuda, and Y. Nakamura: C12orf48, termed PARP-1 binding protein (PARPBP), enhances poly (ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage. Genes Chromosomes and Cancer, 50:13-24, 2011

1130. A. Iida, A. Takahashi, M. Deng, Y. Zhang, J. Wang, N. Atsuta, F. Tanaka, T. Kamei, M. Sano, S. Oshima, T. Tokuda, M. Morita, C. Akimoto, M. Nakajima, M. Kubo, N. Kamatani, I. Nakano, G. Sobue, Y. Nakamura, D. Fan, and S. Ikegawa: Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians. Neurobiology of Aging, 32:757.e13-14, 2011

1131. Y. Tomita, K. Imai, S. Senju, A. Irie, M. Inoue, Y. Hayashida, K. Shiraishi, T. Mori, Y. Daigo, T.

Tsunoda, T. Ito, H. Nomori, Y. Nakamura, H. Kohrogi, and Y. Nishimura: A novel tumor-associated antigen, cell division cycle 45-like can induce cytotoxic T lymphocytes reactive to tumor cells. Cancer Science, 102:697-705, 2011

1132. J.-H. Park, T. Katagiri, S. Chung, K. Kijima, and Y. Nakamura: Polypeptide N-acetylgalactosaminyltransferase 6 (GALNT6) disrupts mammary acinar morphogenesis through O-glycosylation of fibronectin. Neoplasia, 13:320-326, 2011

1133. Y. Kato, H. Zembutsu, R. Takata, F. Miya, T. Tsunoda, W. Obara, T. Fujioka, and Y. Nakamura: Predicting response of bladder cancers to gemcitabine and carboplatin neoadjuvant chemotherapy through genome-wide gene expression profiling. Experimental and Therapeutic Medicine, 2:47-56, 2011

1134. H. Zembutsu, M. Sasa, K. Kiyotani, T. Mushiroda, and Y. Nakamura: Should CYP2D6 inhibitors be administered in conjunction with tamoxifen? Expert Review of Anticancer Therapy, 11:185-193, 2011

1135. S. Maeda, D. Koya, S. Araki, T. Babazono, T. Umezono, M. Toyoda, K. Kawai, M. Imanishi, T. Uzu, D. Suzuki, H. Maegawa, A. Kashiwagi, Y. Iwamoto, and Y. Nakamura: Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes. Clinical Experimental Nephrology, 15:381-390, 2011

1136. K. Okamoto, K. Tokunaga, K. Doi, T. Fujita, H. Suzuki, T. Katoh, T. Watanabe, N. Nishida, A. Mabuchi, A. Takahashi, M. Kubo, S. Maeda, Y. Nakamura, and E. Noiri: Common variation in GPC5 is associated with acquired nephrotic syndrome. Nature Genetics, 43:459-463, 2011

1137. T.A. Johnson, Y. Niimura, H. Tanaka, Y. Nakamura, and T. Tsunoda: hzAnalyzer: Detection, quantification, and visualization of contiguous homozygosity in high-density genotyping datasets. Genome Biology, 12:R21[Epub ahead of print], 2011

1138. K.G. Tantisira, J. Lasky-Su, M. Harada, A. Murphy, A.A. Litonjua, B.E. Himes, C. Lange, R. Lazarus, J. Sylvia, B. Klanderman, Q.L. Duan, W. Qiu, T. Hirota, F.D. Martinez, D. Mauger, C. Sorkness, S. Szefler, S.C. Lazarus, R.F. Lemanske Jr, S.P. Peters, J.J. Lima, Y. Nakamura, M. Tamari, and S.T. Weiss: Genome-wide association of GLCCI1 with asthma steroid treatment response. New Eng. J. Med., 365:1173-1183, 2011

1139. V. Kumar, N. Kato, K. Urabe, A. Takahashi, R. Muroyama, N. Hosono, M. Otsuka, R. Tateishi, M. Omata, H. Nakagawa, K. Koike, N. Kamatani, M. Kubo, Y. Nakamura, and K. Matsuda: Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. Nature Genetics, 43:455-458, 2011

1140. P.-C. Cha, A. Takahashi, N. Hosono, S.-K. Low, N. Kamatani, M. Kubo, and Y. Nakamura: A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids. Nature Genetics, 43:447-450, 2011

1141. F. Nyberg, B.J. Barratt, T. Mushiroda, A. Takahashi, A. Jawaid, S. Hada, T. Umemura, M. Fukuoka, K. Nakata, Y. Ohe, H. Kato, S. Kudoh, R. March, Y. Nakamura, and N. Kamatani: Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer: genome-wide analysis of genetic data. Pharmacogenomics , 12:965-975, 2011

1142. V. Kumar, K. Matsuo, A. Takahashi, N. Hosono, T. Tsunoda, N. Kamatani, S.-Y. Kong, H. Nakagawa, R. Cui, C. Tanikawa, M. Seto, Y. Morishima, M. Kubo, Y. Nakamura, and K. Matsuda: Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility. Journal of Human Genetics, 56:436-439, 2011

1143. Y. Okada, T. Hirota, Y. Kamatani, A. Takahashi, H. Ohmiya, N. Kumasaka, K. Higasa, Y. Yamaguchi-Kabata, N. Hosono, M.A. Nalls, M.H. Chen, F.J.A. van Rooij, A.V. Smith, T. Tanaka, D.J.Couper, N.A. Zakai, L. Ferrucci, D.L. Longo, D.G. Hernandez, J.C.M. Witteman, T.B. Harris, C.J. O'Donnell, S.K. Ganesh, K. Matsuda, T. Tsunoda, T. Tanaka, M. Kubo, Y. Nakamura, M. Tamari, K. Yamamoto, and N. Kamatani: Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. PLoS Genetics, 7:e1002067, 2011

1144. K. Ueda, N. Saichi, S. Takami, D. Kang, A. Toyama, Y. Daigo, N. Ishikawa, N. Kohno, K. Tamura, T. Shuin, A. Yamane, M. Ota, T. Sato, Y. Nakamura, and H. Nakagawa: A comprehensive peptidome profiling technology for the identification of early detection biomarkers for lung adenocarcinoma. PLoS ONE, 6:e18567, 2011

1145. A. Toyama, H. Nakagawa, K. Matsuda, N. Ishikawa, N. Kohno, Y. Daigo, T. Sato, Y. Nakamura, and K. Ueda: Deglycosylation and label-free quantitative LC-MALDI MS applied to efficient serum biomarker discovery of lung cancer. Proteome Science, 9:18, 2011

1146. M. Takawa, K. Masuda, M. Kunizaki, Y. Daigo, K. Takagi, Y. Iwai, H.-S. Cho, G. Toyokawa, Y. Yamane, K. Maejima, H.I. Field, T. Kobayashi, T. Akasu, M. Sugiyama, E. Tsuchiya, Y. Atomi, B.A.J. Ponder, Y. Nakamura, and R. Hamamoto: Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker. Cancer Science, 102:1298-1305, 2011

1147. I. Kou, A. Takahashi, T. Urano, N. Fukui, H. Ito, K. Ozaki, T. Tanaka, T, Hosoi, M. Shiraki, S. Inoue, Y. Nakamura, N. Kamatani, M. Kubo, S. Mori, and S. Ikegawa: Common variants in a novel gene, FONG on chromosome 2q33.1 confer risk of osteoporosis in Japanese. PLoS ONE, 6:e19641, 2011

1148. M.A. Nalls, D.J. Couper, T. Tanaka, F.J.A. van Rooij, M-H. Chen, A.V. Smith, D. Toniolo, N.A.

Zakai, Q. Yang, A. Greinacher, A.R. Wood, M. Garcia, P. Gasparini, Y. Liu, T. Lumley, A.R. Folsom, A.P. Reiner, C. Gieger, V. Lagou, J.F. Felix, H. Völzke, N.A. Gouskova, A. Biffi, A. Döring, U. Völker, S. Chong, K.L. Wiggins, A. Rendon, A. Dehghan, M. Moore, K. Taylor, J.G. Wilson, G. Lettre, A. Hofman, J.C. Bis, N. Pirastu, C.S. Fox, C. Meisinger, J. Sambrook, S. Arepalli, M. Nauck, H. Prokisch, J. Stephens, N.L. Glazer, L.A. Cupples, Y. Okada, A. Takahashi, Y. Kamatani, K. Matsuda, T. Tsunoda, T. Tanaka, M. Kubo, Y. Nakamura, K. Yamamoto, N. Kamatani, M. Stumvoll, A. Tönjes, I. Prokopenko, T. Illig, K.V. Patel, S.F. Garner, B. Kuhnel, M. Mangino, B.A. Oostra, S.L. Thein, J. Coresh, H.-E. Wichmann, S. Menzel, J. Lin, G. Pistis, A.G. Uitterlinden, T.D. Spector, A. Teumer, G. Eriksdottir, V. Gudnason, S. Bandinelli, T. Frayling, A. Chakravarti, C.M. van Duijn, D. Melzer, W.H. Ouwehand, D. Levy, E. Boerwinkle, A.B. Singleton, D.G. Hernandez, D.L. Longo, N. Soranzo, J.C.M. Witteman, B.M. Psaty, L. Ferrucci, T.B. Harris, C.J. O'Donnell, and S.K. Ganesh: Multiple loci are associated with white blood cell phenotypes. PLoS Genetics, 7:e1002113, 2011

1149. C. Terao, R. Yamada, K. Ohmura, M. Takahashi, T. Kawaguchi, Y. Kochi, Human Disease Genomics Working Group, RA Clinical and Genetic Study Consortium, Y. Okada, Y. Nakamura, K. Yamamoto, I. Melchers, M. Lathrop, T. Mimori, and F. Matsuda: The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population. Human Molecular Genetics, 20:2680-2685, 2011

1150. K. Chayama, C.N. Hayes, H. Abe, D. Miki, H. Ochi, Y. Karino, J. Toyota, Y. Nakamura, N. Kamatani, H. Sezaki, M. Kobayashi, N. Akuta, F. Suzuki, and H. Kumada: IL28B but not ITPA polymorphism is predictive of response to peg-interferon, ribavirin and telaprevir triple therapy in patients with genotype 1 hepatitis C. Journal of Infectious Diseases, 204:84-93, 2011

1151. T. Azakami, C.N. Hayes, H. Sezaki, M. Kobayashi, N. Akuta, F. Suzuki, H. Kumada, H. Abe, D. Miki, M. Tsuge, M. Imamura, Y. Kawakami, S. Takahashi, H. Ochi, Y. Nakamura, N. Kamatani, and K. Chayama: Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy. Journal of Medical Virology, 83:1048-1057, 2011

1152. H. Ochi , T. Maekawa, H. Abe, Y. Hayashida, R. Nakano, M. Imamura, N. Hiraga, Y. Kawakami, S. Aimitsu, J.-H. Kao, M. Kubo, T. Tsunoda, H. Kumada, Y. Nakamura, C.N. Hayes, and K. Chayama: IL-28B predicts response to chronic hepatitis C therapy - fine-mapping and replication study in Asian populations. Journal or General Virology, 92:1071-1081, 2011

1153. T. Mushiroda, Y. Nakamura: Personalizing carbamazepine therapy (Review). Genomic Medicine, 3:28, 2011

1154. S. Chantarangsu, T. Mushiroda, S. Mahasirimongkol, S. Kiertiburanakul, S. Sungkanuparph, W. Manosuthi, W. Tantisiriwat, A. Charoenyingwattana, T. Sura, A. Takahashi, M. Kubo, N. Kamatani, W. Chantratita, and Y. Nakamura: Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash. Clinical Infectious Diseases, 53:341-348, 2011

1155. G. Toyokawa, K. Masuda, Y. Daigo, H.-S. Cho, M. Yoshimatsu, M. Takawa, S. Hayami, K. Maejima, M. Chino, H.I. Field, D.E. Neal, E. Tsuchiya, B.A.J. Ponder, Y. Maehara, Y. Nakamura, and R. Hamamoto: Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer. Molecular Cancer, 10:65, 2011

1156. Y. Srinivasan, M. Sasa, J. Honda, A. Takahashi, S. Uno, N. Kamatani, M. Kubo, Y. Nakamura, and H. Zembutsu: Genome-wide association study of epirubicin-induced leukopenia in Japanese patients. Pharmacogenetics and Genomics, 21:552-558, 2011

1157. H.-S. Cho, J. D. Kelly, S. Hayami, G. Toyokawa, M. Takawa, M. Yoshimatsu, T. Tsunoda, H. I. Field, D. E. Neal, B. A.J. Ponder, Y. Nakamura, and R. Hamamoto: Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1. Neoplasia, 13:678-684, 2011

1158. T. Tanabe, N. Yamaguchi, K. Matsuda, K. Yamazaki, S. Takahashi, A. Tojo, M. Onizuka, Y. Eishi, H. Akiyama, J. Ishikawa, T. Mori, M. Hara, K. Koike, K. Kawa, T. Kawase, Y. Morishima, H. Amano, M. Kobayashi-Miura, T. Kakamu, Y. Nakamura, S. Asano, and Y. Fujita: Association analysis of the NOD2 gene with susceptibility to graft-versus-host disease in a Japanese population. International Journal of Hematology, :DOI 10.1007/s12185-011-0860-5, 2011

1159. D. Miki, H. Ochi, C.N. Hayes, H. Abe, T. Yoshima, H. Aikata, K. Ikeda,H. Kumada, J. Toyota, T. Morizono, T. Tsunoda, M. Kubo, Y. Nakamura, N. Kamatani, and K. Chayama: Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers. Nature Genetics, 43:797-800, 2011

1160. T. Hirota, A. Takahashi, M. Kubo, T. Tsunoda, K. Tomita, S. Doi, K. Fujita, A. Miyatake, T. Enomoto, T. Miyagawa, M. Adachi, H. Tanaka, A. Niimi, H. Matsumoto, I. Ito, H. Masuko, T. Sakamoto, N. Hizawa, M. Taniguchi, J.J. Lima, C.G. Irvin, S.P. Peters, B.E. Himes, A.A. Litonjua, K.G. Tantisira, S.T. Weiss, N. Kamatani, Y. Nakamura, and M. Tamari: Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nature Genetics, 43:893-896, 2011

1161. S. Arakawa, A. Takahashi, K. Ashikawa, N. Hosono, T. Aoi, M. Yasuda, Y. Oshima, S. Yoshida,

H. Enaida, T. Tsuchihashi, K. Mori, S. Honda, A. Negi, A. Arakawa, K. Kadonosono, Y. Kiyohara, N. Kamatani, Y. Nakamura, T. Ishibashi, and M. Kubo: Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population. Nature Genetics, 43:1001-1004, 2011

1162. A.P. Reiner, G. Lettre, M.A. Nalls, S.K. Ganesh, R. Mathias, M.A. Austin, E. Dean, S. Arepalli, A. Britton, Z. Chen, D. Couper, J.D. Curb, C.B. Eaton, M. Fornage, S.F.A. Grant, T.B. Harris, D. Hernandez, N. Kamatani, B.J. Keating, M. Kubo, A. LaCroix, L.A. Lange, S. Liu, K. Lohman, Y. Meng, E.R. Mohler Ⅲ, S. Musani, Y. Nakamura, C.J. O'Donnell, Y. Okada, C.D. Palmer, G.J. Papanicolaou, K.V. Patel, A.B. Singleton, A. Takahashi, H. Tang, H.A. Taylor Jr., K. Taylor, C. Thomson, L.R. Yanek, L. Yang, E. Ziv, A.B. Zonderman, A.R. Folsom, M.K. Evans, Y. Liu, D.M. Becker, B.M. Snively, and J.G. Wilson: Genome-wide association study of white blood cell count in 16,388 African Americans: the Continental Origins and Genetic Epidemiology Network (COGENT). PLoS Genetics, 7:e1002108, 2011

1163. Y. Okada, A. Takahashi, H. Ohmiya, N. Kumasaka, Y. kamatani, N. Hosono, T. Tsunoda, K. Matsuda, T. Tanaka, M. Kubo, Y. Nakamura, K. Yamamoto, and N. Kamatani: Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus. Human Molecular Genetics, 20:1224-1231, 2011

1164. A. Iida, A. Takahashi, M. Kubo, S. Saito, N. Hosono, Y. Ohnishi, K. Kiyotani, T. Mushiroda, M. Nakajima, K. Ozaki, T. Tanaka, T. Tsunoda, S. Oshima, M. Sano, T. Kamei, T. Tokuda, M. Aoki, K. Hasegawa, K. Mizoguchi, M. Morita , Y. Takahashi, M. Katsuno, N. Atsuta, H. Watanabe, F. Tanaka, R. Kaji, I. Nakano, N. Kamatani, S. Tsuji, G. Sobue, Y. Nakamura, and S. Ikegawa: A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese. Human Molecular Genetics, 20:3684-3692, 2011

1165. A. Yosifova, T. Mushiroda, M. Kubo, A. Takahashi, Y. Kamatani, N. Kamatani, D. Stoianov, R. Vazharova, S. Karachanak, I. Zaharieva, I. Dimova, S. Hadjidekova, V. Milanova, N. Madjirova, I. Gerdjikov, T. Tolev, N. Poryazova, G. Kirov, M. Owen, M. O'Donovan, D. Toncheva, and Y. Nakamura: Genome wide association study on bipolar disorder in the Bulgarian population. Genes, Brain and Behavior, 10:789-797, 2011

1166. H. Mbarek, H. Ochi, Y. Urabe, V. Kumar, M. Kubo, N. Hosono, A. Takahashi, Y. Kamatani, D. Miki, H. Abe, T. Tsunoda, N. Kamatani, K. Chayama, Y. Nakamura, and K. Matsuda: A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. Human Molecular Genetics, 20:3884-3892, 2011

1167. S. Chung, M. Nakashima, H. Zembutsu, and Y. Nakamura: Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production. Proceedings of the Japan Academy. Series B-Physical and Biological Sciences, 87:563-573, 2011

1168. M. Aragaki, K. Takahashi, H. Akiyama, E. Tsuchiya, S. Kondo, Y. Nakamura, and Y. Daigo: Characterization of a Cleavage Stimulation Factor, 3’ pre-RNA, Subunit 2, 64kDa (CSTF2) as a therapeutic target for lung cancer. Clinical Cancer Research, 17:5889-5900, 2011

1169. R. Nishino, A. Takano, H. Oshita, N. Ishikawa, H. Akiyama, H. Ito, H. Nakayama, Y. Miyagi, E. Tsuchiya, N. Kohno, Y. Nakamura, and Y. Daigo: Identification of Epstein-Barr virus-induced gene 3 as a novel serum and tissue biomarker and a therapeutic target for lung cancer. Clinical Cancer Research, 17:6272-6286, 2011

1170. K. Masuda, A. Takano, H. Oshita, H. Akiyama, E. Tsuchiya, N. Kohno, Y. Nakamura, and Y. Daigo: Chondrolectin is a novel diagnostic biomarker and a therapeutic target for lung cancer. Clinical Cancer Research, 17:7712-7722, 2011

1171. J.C. Chambers, W. Zhang, J. Sehm, Y. Nakamura et al. Identification of genetic loci influencing markers of liver function in man. Nature Genetics, 43:1131-1138, 2011

1172. N. Kumasaka, H. Fujisawa, N. Hosono, Y. Okada, A. Takahashi, Y. Nakamura, M. Kubo, and N. Kamatani: Platinum CNV: a bayesian gaussian mixture model for genotyping copy number polymorphisms using SNP array signal intensity data. Genetic Epidemiology, 35:831-844, 2011

1173. K. Kiyotani, T. Mushiroda and Y. Nakamura: Pharmacogenomics of anticonvulsant agents (review). BioTech International, 22:16-18, 2011

1174. G. Toyokawa, H.-S. Cho, K. Masuda, M. Yoshimatsu, S. Hayami, M. Takawa, Y. Iwai, Y. Daigo, E. Tsuchiya, T. Tsunoda, H.I. Field, J.D. Kelly, D.E. Neal, Y. Maehara, B.A.J. Ponder, Y. Nakamura, and R. Hamamoto: The histone lysine methyltransferase Wolf-Hirschhorn Syndrome Candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway. Neoplasia, 13:887-898, 2011

1175. J. Li, D. Yang, Y. He, M. Wang, Z. Wen, L. Liu, J. Yao, K. Matsuda, Y. Nakamura, J. Yu, X. Jiang, S. Sun, Q. Liu, X. Jiang, Q. Song, M. Chen, H. Yang, F. Tang, X. Hu, J. Wang, Y. Chang, X. He, Y. Chen, and J. Lin: Associations of HLA-DP variants with hepatitis B virus infection in Southern and Northern Han Chinese populations: A multicenter case-control study. PLoS ONE, 6:e24221, 2011

1176. G. Toyokawa, H.-S. Cho, Y. Iwai, M. Takawa, M. Yoshimatsu, S. Hayami, K. Maejima, N. Shimizu, H. Tanaka, T. Tsunoda, H. I. Field, J. D. Kelly, D. E. Neal, B.A.J. Ponder, Y. Maehara, Y. Nakamura, and R. Hamamoto: The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase. Cancer Prevention

Research, 4:2051-2061, 2011 1177. M. Imamura, M. Iwata, H. Maegawa, H. Watada, H. Hirose, Y. Tanaka, K. Tobe, K. Kaku, A.

Kashiwagi, R. Kawamori, Y. Nakamura, and S. Maeda: Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population. Diabetologia, 54:3071–3077, 2011

1178. T. Ohshige, M. Iwata, S. Omori, Y. Tanaka, H. Hirose, K. Kaku, H. Maegawa, H. Watada, A. Kashiwagi, R. Kawamori, K. Tobe, T. Kadowaki, Y. Nakamura, and S. Maeda: Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. PLoS ONE, 6:e26911, 2011

1179. C. Gieger, A. Radhakrishnan, A. Cvejic, W. Tang, Y. Nakamura, et al.: New gene functions in megakaryopoiesis and platelet formation. Nature, 480:201-208, 2011

1180. T. Hirota, H. Saeki, K. Tomita, S. Tanaka, K. Ebe, M. Sakashita, T. Yamada, S. Fujieda, A. Miyatake, S. Doi, T. Enomoto, N. Hizawa, T. Sakamoto, H. Masuko, T. Sasaki, T. Ebihara, M. Amagai, H. Esaki, S. Takeuchi, M. Furue, E. Noguchi, N. Kamatani, Y. Nakamura, M. Kubo, and M. Tamari: Variants of C-C motif chemokine 22 (CCL22) are associated with susceptibility to atopic dermatitis: case-control studies. PLoS ONE, 6:e26987, 2011

1181. H. Abe, C. N. Hayes, H. Ochi, M. Tsuge, D. Miki, N Hiraga, M. Imamura, S. Takahashi, M. Kubo, Y. Nakamura, N. Kamatani, and K. Chayama: Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state. Journal of Medical Virology, 83:1597–1607, 2011

1182. M. Furu, Y. Kajita, S. Nagayama, T. Ishibe, Y. Shima, K. Nishijo, D. Uejima, R Takahashi, T. Aoyama, T. Nakayama, T Nakamura, Y. Nakashima, M. Ikegawa, S. Imoto, T. Katagiri, Y. Nakamura, and J. Toguchida: Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas. Oncogene, 30:4015-4025, 2011

1183. K. Yasuno, M. Bakırcıoğlu, S.-K. Low, K. Bilgüvar, E. Gaál, Y.M. Ruigrok, M. Niemelä, A. Hata, P. Bijlenga, H. Kasuya, J.E. Jääskeläinen, D. Krex, G. Auburger, M. Simon, B. Krischek, A.K.Ozturk, S. Mane, G.J. Rinkel, H. Steinmetz, J. Hernesniemi, K. Schaller, H. Zembutsu, I. Inoue, A. Palotie, F. Cambien, Y. Nakamura, R.P. Lifton, and M. Günel: Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk. Proc. Natl. Acad. Sci. USA, 108:19707-19712, 2011

1184. K. Dabanaka, S.-Y. Chung, H. Nakagawa, Y. Nakamura, T. Okabayashi, T. Sugimoto, K. Hanazaki, and M. Furihata: PKIB expression strongly correlated with phosphorylated Akt expression in the breast cancers and also with triple negative breast cancer subtype. Medical Molecular Morphology, :DOI 10.1007/s00795-011-0565-0, 2011

1185. P.Y. Yew, T. Mushiroda, K. Kiyotani, G.K. Govindasamy, L.F. Yap, S.H. Teo, P.V. Lim, S. Govindaraju, K. Ratnavelu, C.K. Sam, Y.Y. Yap, A.S. Khoo, K.C. Pua, Y. Nakamura, The Malaysian NPC Study Group, and C.C. Ng Identification of a functional variant in SPLUNC1 associated with nasopharyngeal carcinoma susceptibility among Malaysian Chinese. Molecular Carcinognesis, :doi: 10.1002/mc.21857, 2011

1186. K. Nakabayasi, A. Tajima, K. Yamamoto, A. Takahashi, K. Hata, Y. Takashima, M. Koyanagi, H. Nakaoka, T. Akamizu, N. Ishikawa, S. Kubota, S. Maeda, T. Tsunoda, M. Kubo, N. Kamatani, Y. Nakamura, T. Sasazuki, S. Shirasawa: Identification of independent risk loci for Graves' disease within the MHC in the Japanese population. Journal of Human Genetics, 56:772-778, 2011

1187. M. P. Goetz, D.J. Schaid, D.L. Wickerham, S. Safgren, T. Mushiroda, M. Kubo, A. Batzler, J.P. Costantino, V.G. Vogel, S. Paik, E.E. Carlson, D.A. Flockhart, N. Wolmark, Y. Nakamura, R.M. Weinshilboum, J.N. Ingle, M.M. Ames: Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: results from the NSABP P1 and P2 clinical trials. Clinical Cancer Research, 17:6944-6951, 2011

1188. E. Noguchi, H. Sakamoto, T. Hirota, K. Ochiai, Y. Imoto, M. Sakashita, F. Kurosaka, A. Akasawa, S. Yoshihara, N. Kanno, Y. Yamada, N. Shimojo, Y. Kohno, Y. Suzuki, M.J. Kang, J.W. Kwon, S.J. Hong, K. Inoue, Y. Goto, F. Yamashita, T. Asada, H. Hirose, I. Saito, S. Fujieda, N. Hizawa, T. Sakamoto, H. Masuko, Y. Nakamura, I. Nomura, M. Tamari, T. Arinami, T. Yoshida, H. Saito, and K. Matsumoto: Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. PLoS Genetics, 7:e1002170, 2011

1189. Y. Okada, K. Yamazaki, J. Umeno, A. Takahashi, N. Kumasaka, K. Ashikawa, T. Aoi, M. Takazoe, T. Matsui, A. Hirano, T. Matsumoto, N. Kamatani, Y. Nakamura, K. Yamamoto, and M. Kubo: HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease. Gastroenterology, 141:864-871, 2011

1190. N. Hiraga, H. Abe, M. Imamura, M. Tsuge, S. Takahashi, C.N. Hayes, H. Ochi, C. Tateno, K. Yoshizato, Y. Nakamura, N. Kamatani, and K. Chayama: Impact of viral amino acid substitutions and host interleukin-28b polymorphism on replication and susceptibility to interferon of hepatitis C virus. Hepatology, 54:764-771, 2011

1191. K. Yamaguchi, M Sakai, J. Kim, S. Tsunesumi, T. Fujii, T. Ikenoue, Y. Yamada, Y. Akiyama, Y. Muto, R. Yamaguchi, S. Miyano, Y. Nakamura, and Y. Furukawa: MRG-binding protein contributes to colorectal cancer development. Cancer Science, 102:1486-92, 2011

1192. M. Harada, T. Hirota, T, A. J. Jodo, Y. Hitomi, M. Sakashita, T. Tsunoda, T. Miyagawa, S.

Doi, Satoru, M. Kameda, K. Fujita, A. Miyatake, T. Enomoto, E. Noguchi, H. Masuko, T. Sakamoto, N. Hizawa, Y. Suzuki, S. Yoshihara, M. Adachi, M. Ebisawa, H. Saito, K. Matsumoto, T. Nakajima, R. Mathias, N. Rafaels, K. C. B. E. Himes, Q. L. Duan, K. G. Tantisira, S.T. Weiss, Y. Nakamura, S. F. Ziegler, and T. Tamari: Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma American Journal of Respiratory Cell and Molecular Biology , 44:787-793, 2011

1193. S.-K. Low, H. Zembutsu, A. Takahashi, N. Kamatani, P.-C. Cha, N. Hosono, M. Kubo, K. Matsuda, and Y. Nakamura: Impact of LIMK1, MMP2 and TNF-alpha variations for intracranial aneurysm in Japanese population Journal of Human Genetics, 56:211-216, 2011

1194. K. Yamamoto, T. Ishida, K. Nakano, M. Yamagishi, T. Yamochi, Y. Tanaka, Y. Furukawa, Y. Nakamura, and T. Watanabe: SMYD3 interacts with HTLV-1 Tax and regulates subcellular localization of Tax Cancer Science, 102:260-266 , 2011

1195. K. Nishimoto, K. Ikari, H. Kaneko, S. Tsukahara, Y. Kochi, K. Yamamoto, Y. Nakamura, Y. Toyama, A. Taniguchi, H. Yamanaka, and S. Momohara: Association of EMCN with susceptibility to rheumatoid arthritis in a Japanese population. Journal of Rheumatology, 38::221-228, 2011

1196. Y.Yamanaka, A. Kitano, K. Takao, A. Prasansuklab, T. Mushiroda, K. Yamazaki, T. Kumada, M. Shibata, Y. Takaoka, T. Awaya, T. Kato, T. Abe, N. Iwata, T. Miyakawa, Y. Nakamura, T. Nakahata, and T. Heike: Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors. Molecular and Cellular Neuroscience, 46:200-212, 2011

1197. N. Saeki, A. Saito, I.J. Choi, K. Matsuo, S. Ohnami, H. Totsuka, S. Chiku, A. Kuchiba, Y.S. Lee, K.A. Yoon, M.C. Kook, S.R. Park, Y.W. Kim, H. Tanaka, K. Tajima, H. Hirose, F. Tanioka, Y. Matsuno, H. Sugimura, S. Kato, T. Nakamura, T. Nishina, W. Yasui, K. Aoyagi, H. Sasaki, K. Yanagihara, H. Katai, T. Shimoda, T. Yoshida, Y. Nakamura, S. Hirohashi, and H. Sakamoto: A Functional single nucleotide polymorphism in Mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer. Gastroenterology, 892:892-902, 2011

1198. Y. Kochi, M.M. Thabet, A. Suzuki, Y. Okada, N.A. Daha, R.E.M. Toes, T.W.J. Huizinga, TWJ, K. Myouzen, M. Kubo, R. Yamada, Y. Nakamura, and K. Yamamoto: PADI4 polymorphism predisposes male smokers to rheumatoid arthritis. Annals of Rheumatic Diseases, 70:512-515, 2011

1199. J. Umeno, K. Asano, T. Matsushita, T. Matsumoto, Y. Kiyohara, M. Iida, Y. Nakamura, N. Kamatani, M. Kubo: Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis. Inflammatory Bowel Diseases, 17:2407-2415, 2011

1200. H. Abe, C.N. Hayes, H. Ochi, T. Maekawa, M. Tsuge, D. Miki, F. Mitsui, N. Hiraga, M. Imamura, S. Takahashi, M. Kubo, Y. Nakamura, and K. Chayama: IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy. Journal of Hepatology, 54:1094-1101, 2011

1201. N. Kumasaka, M. Aoki, Y. Okada, A. Takahashi, K. Ozak, T. Mushiroda, T. Hirota, M. Tamari, T. Tanaka, Y. Nakamura, N. Kamatani, and M. Kubo: Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population。 Plos One, 7:e44507, 2012

1202. H.-S. Cho, G. Toyokawa, Y. Daigo, S. Hayami, K. Masuda, N. Ikawa, Y. Yamane, K. Maejima, M. Yoshimatsu, T. Tsunoda, H. I. Field, J. D. Kelly, D. E. Neal, B. A.J. Ponder, Y. Maehara, Y. Nakamura, and R. Hamamoto: The JmjC domain-containing histone demethylase KDM3A Is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene. International Journal of Cancer, 131:179-189, 2012

1203. F. Innocenti, K. Owzar, N.L. Cox, P. Evans, M. Kubo, H. Zembutsu, C. Jiang, D. Hollis, T. Mushiroda, L. Li, P. Friedman, L. Wang, H. Hurwitz, K.M. Giacomini, H.L. McLeod, R.M. Goldberg, R.L. Schilsky, H.L. Kindler, Y. Nakamura, and M.J. Ratain: A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Clinical Cancer Research, 18:577-584, 2012

1204. M. Maimbo, K. Kiyotani, T. Mushiroda, C. Masimirembwa, and Y. Nakamura: CYP2B6 genotype is a strong predictor of systemic exposure to efavirenz in HIV-infected Zimbabweans. European Journal of Clinical Pharmacology, 68:267-271, 2012

1205. N. Akuta, F. Suzuki, M. Hirakawa, Y. Kawamura, H. Sezaki, Y. Suzuki, T. Hosaka, M. Kobayashi, M. Kobayashi, S. Saitoh, Y. Arase, K. Ikeda, K. Chayama, Y. Nakamura, and H. Kumada: Amino acid substitution in HCV core/NS5A region and genetic variation near IL28B gene affect treatment efficacy to interferon plus ribavirin combination therapy. Intervirology, 55:231-241, 2012

1206. K. Kiyotani, T. Mushiroda, Y. Nakamura, and H. Zembutsu: Pharmacogenomics of tamoxifen: roles of drug metabolizing enzymes and transporters. Drug Metabolism and Pharmacokinetics, 27:122-131, 2012

1207. J. Koinuma, H. Akiyama, M. Fujita, M. Hosokawa, E. Tsuchiya, S. Kondo, Y. Nakamura, and Y. Daigo: Characterization of an Opa interacting protein 5 (OIP5) involved in lung and esophageal carcinogenesis. Cancer Science, 103:577-586, 2012

1208. K. Kiyotani, S. Uno, T. Mushiroda, A. Takahashi, M. Kubo, N. Mitsuhata, S. Ina, C. Kihara, Y. Kimura, H. Yamaue, K. Hirata, Y. Nakamura, and H. Zembutsu: Genome-wide association study

identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy. Pharmacogenetics and Genomics, 22:229-235, 2012

1209. Y. Okada, M. Kubo, H. Ohmiya, A. Takahashi, N. Kumasaka, N. Hosono, S. Maeda, W. Wen, R. Dorajoo, M.-J. Go, W. Zheng, N. Kato, J.-Y. Wu, Q. Lu, the GIANT consortium, T. Tsunoda, K. Yamamoto, Y. Nakamura, N. Kamatani, and T. Tanaka: Common variants at CDKAL1 and KLF9 are associated with body mass index in East Asian populations. Nature Genetics, 44:302-306, 2012

1210. W. Wen, Y.S. Cho, W. Zheng, R. Dorajoo, Y. Nakamura, et al.: Meta-analysis of genome-wide association studies in East Asians identifies novel genetic variants associated with body mass index. Nature Genetics, 44:307-311, 2012

1211. R. Abo, S. Hebbring, Y. Ji, H. Zhu, Z.-B. Zeng, A. Batzler, G. D. Jenkins, J. Biernacka, K. Snyder, M. Drews, O. Fiehn, B. Fridley, D.Schaid, N. Kamatani, Y. Nakamura, M. Kubo, T. Mushiroda, R. Kaddurah-Daouk, D. A. Mrazek, and R. M. Weinshilboum: Merging pharmacometabolomics with pharmacogenomics using “1000 Genomes” SNP imputation: Selective serotonin reuptake inhibitor response pharmacogenomics. Pharmacogenetics and Genomics, 22:247-253, 2012

1212. H. Nakagawa, S. Akamatsu, R. Takata, A. Takahashi, M. Kubo, and Y. Nakamura: Prostate cancer genomics, biology, and risk assessment through genome-wide association studies. Cancer Science, 103:607-613, 2012

1213. K. Kiyotani, T. Mushiroda, T. Tsunoda, T. Morizono, N. Hosono, M. Kubo, Y. Tanigawara, C.K. Imamura, D.A. Flockhart, F. Aki, K. Hirata, Y. Takatsuka, M. Okazaki, S. Ohsumi, T. Yamakawa, M. Sasa, Y. Nakamura, and H. Zembutsu: A Genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients. Human Molecular Genetics, 21:1665-1672, 2012

1214. H. Yoshioka, S. Yamamoto, H. Hanaoka, Y. Iida, P. Paudya, T. Higuchi, H. Tominaga, N. Oriuchi, H. Nakagawa, Y. Shiba, K. Yoshida, R. Osawa, T. Katagiri, T. Tsunoda, Y. Nakamura, and K. Endo: In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmunotherapy. Cancer Immunology, Immunotherapy, 61:1211–1220, 2012

1215. C. Tanikawa, Y. Urabe, K. Matsuo, M. Kubo, A. Takahashi, H. Ito, K. Tajima, N. Kamatani,Y. Nakamura, and K. Matsuda: Genome wide association study identified two susceptible loci for duodenal ulcer in Japanese population. Nature Genetics, 44:430-441, 2012

1216. Y. Urabe, C. Tanikawa, A. Takahashi, Y. Okada, T. Morizono, T. Tsunoda, N. Kamatani, K. Kohri, K. Chayama, M. Kubo, Y. Nakamura, and K. Matsuda: Genome-wide association study of nephrolithiasis in Japanese population identifies novel susceptible loci at 5q35.3, 7p14.3 and 13q14.1. PLoS Genetics, 8:e1002541, 2012

1217. S.-K. Low, A. Takahashi, P.-C. Cha, H. Zembutsu, N. Kamatani, M. Kubo, and Y. Nakamura: Genome-wide association study for intracranial aneurysm in Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA. Human Molecular Genetics, 21:2102-2110, 2012

1218. C. Tanikawa, M. Espinosa, A. Suzuki, K. Masuda, K. Yamamoto, E. Tsuchiya, K. Ueda, Y. Daigo, Y. Nakamura, and K. Matsuda: Regulation of histone modification and chromatin structure by the p53-PADI4 pathway. Nature Communications, :DOI 10.1038, 2012

1219. P.-C. Cha, H. Zembutsu, A. Takahashi, M. Kubo, N. Kamatani, and Y. Nakamura: A genome-wide association study (GWAS) identifies SNP in DCC is associated with gallbladder cancer (GC) in the Japanese population. Journal of Human Genetics, 57:235-237, 2012

1220. S. Akamatsu, R. Takata, C.A. Haiman, A. Takahashi, T. Inoue, M. Kubo, M. Furihata, N. Kamatani, J. Inazawa, G.K. Chen, L.L. Marchand, L.N. Kolonel, T. Katoh, Y. Yamano, M. Yamakado, H. Takahashi, H. Yamada, S. Egawa, T. Fujioka, B.E. Henderson, T. Habuchi, O. Ogawa, Y. Nakamura, and H. Nakagawa: Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese. Nature Genetics, 44:426-429, 2012

1221. W.-C. Chang, C.-H. Lee, T. Hirota, L.-F. Wang, S. Doi, A. Miyatake, T. Enomoto, K. Tomita, M. Sakashita, T. Yamada, S. Fujieda, K. Ebe, H. Saeki, S. Takeuchi, M. Furue, W.-C. Chen, Y.-C. Chiu, W. P. Chang, C.-H. Hong, E. Hsi, S.-H. H. Juo, H.-S. Yu, Y. Nakamura, and M. Tamari: ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese andTaiwanese populations. PLoS ONE, 7:e29387, 2012

1222. W. Osman, Y. Okada, Y. Kamatani, M. Kubo, K. Matsuda, and Y. Nakamura: Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in the Japanese population. PLoS ONE, 7:e32683 , 2012

1223. H.H. Nguyen, R. Takata, S. Akamatsu, D. Shigemizu, T. Tsunoda, M. Furihata, A. Takahashi, M. Kubo, N. Kamatani, O. Ogawa, T. Fujioka, Y Nakamura, and H. Nakagawa: IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility. Human Molecular Genetics, 21:2076-2085, 2012

1224. Y. Okada, C. Terao, K. Ikari, Y. Kochi, K. Ohmura, A. Suzuki, T. Kawaguchi, E. Stahl, F. Kurreman, N. Nishida, H. Ohmiya, K. Myouzen, M. Takahashi, T. Sawada, Y. Nishioka, M. Yukioka, T. Matsubara, S. Wakitani, R. Teshima, S. Tohma, K. Takasugi, K. Shimada, A. Murasawa, S. Honjo, K. Matsuo, H. Tanaka, K. Tajima, T. Suzuki, T. Iwamoto, Y. Kawamura, H. Tanii, Y. Okazaki, T. Sasaki, P.K. Gregersen, L. Padyukov, J. Worthington, K.A. Siminovitch, M.

Lathrop, A. Taniguchi, A. Takahashi, K. Tokunaga, M. Kubo, Y. Nakamura, N. Kamatani, T. Mimori, R.M. Plenge, H. Yamanaka, S. Momohara, R. Yamada, F. Matsuda, and K. Yamamoto: Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nature Genetics, 44:511-516, 2012

1225. W. Jongjaroenpraser, T. Phusantisampan, S. Mahasirimongkol, T. Mushiroda, N. Hirankarn, T. Snabboon, S. Chanprasertyotin, P. Tantiwong, S. Soonthornpun, P. Rattanapichart, S. Mamanasiri, T. Himathongkam, B. Ongphiphadhanakul, A. Takahashi, N. Kamatani, M. Kubo, and Y. Nakamura: A genome-wide association study identifies novel susceptibility loci for thyrotoxic hypokalemic periodic paralysis. Journal of Human Genetics, 57:301-304, 2012

1226. M. Aoki, N. Hosono, S. Kakata, Y. Nakamura, N. Kamatani, and M. Kubo: New pharmacogenetic test for detecting HLA-A*31:01 allele using invaderPlus assay. Pharmacogenetics and Genomics, 22:441-446, 2012

1227. K. Kiyotani, T. Mushiroda, C.K. Imamura, Y. Tanigawara, N. Hosono, M. Kubo, M. Sasa, Y. Nakamura, and H. Zembutsu: Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients. Breast Cancer Res Treat, 131:137-145, 2012

1228. C. Tanikawa, H. Nakagawa, Y. Furukawa, Y. Nakamura, and K. Matsuda: CLCA2 as a p53-inducible senescence mediator. Neoplasia, 14:141-147, 2012

1229. Y. Yamaguchi-Kabata, T. Tsunoda, N. Kumasaka, A. Takahashi, N. Hosono, M. Kubo, Y. Nakamura, and N. Kamatani: Genetic differences in the two main groups of the Japanese population based on autosomal SNPs and haplotypes. Journal of Human Genetics, 57:326-334, 2012

1230. Y. Onouchi, K. Ozaki, J.C. Burns, C. Shimizu, M. Terai, H. Hamada, T. Honda, H. Suzuki, T. Suenaga, T. Takeuchi, N. Yoshikawa, Y. Suzuki K. Yasukawa, R. Ebata, K. Higashi, T. Saji, Y. Kemmotsu, S. Takatsuki, K. Ouchi, F. Kishi, T. Yoshikawa, T. Nagai, K. Hamamoto, Y. Sata, A. Honda, H. Kobayashi, J. Sato, S. Shibuta, M. Miyawaki, K. Oishi, H. Yamaga, N. Aoyagi, S. Iwahashi, R. Miyashita, Y. Murata, K. Sasago, A. Takahashi, N. Kamatani, M. Kubo, T. Tsunoda, A. Hata, Y. Nakamura, T. Tanaka, and Japan Kawasaki Disease Genome Consortium & U.S. Kawasaki Disease Genetics Consortium: A genome-wide association study identifies three new loci for Kawasaki disease. Nature Genetics, 44:517-521, 2012

1231. W. Osman, S.-K. Low, A. Takahashi, M. Kubo, and Y. Nakamura: A Genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma. Human Molecular Genetics, 21:2836-2842, 2012

1232. S. Mahasirimongkol, H. Yanai, T. Mushiroda, W. Promphittayarat, S. Wattanapokayakit, J. Promjai, R. Yuliwulandari, N. Wichukchinda, A. Yowang, N. Yamada, P. Kantipong, A. Takahashi, M. Kubo, P. Sawanpanyalert, N. Kamatani, Y. Nakamura, and K. Tokunaga: Genome-wide association studies of tuberculosis in Asians identify distinct at-risk locus for young tuberculosis. Journal of Human Genetics, 57:363-367, 2012

1233. M Liu, L. Wang, T. Bongartz, J.R. Hawse, S.N. Markovic, D.J. Schaid, T. Mushiroda, M. Kubo, Y. Nakamura, N. Kamatani, P.E. Goss, J.N. Ingle, and R.M. Weinshilboum: Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression. Breast Cancer Research, 9:R41, 2012

1234. M. Imamura, S. Maeda, T. Yamauchi, K. Hara, K. Yasuda, T. Morizono, A. Takahashi, M. Horikoshi, M. Nakamura, H. Fujita, T. Tsunoda, M. Kubo, H. Watada, H. Maegawa, M. Okada-Iwabu, M. Iwabu, N. Shojima, T. Ohshige, S. Omori, M. Iwata, H. Hirose, K. Kaku, C. Ito, Y. Tanaka, K. Tobe, A. Kashiwagi, R. Kawamori, M. Kasuga, N. Kamatani, Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Y. Nakamura, and T. Kadowaki: A single nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. Human Molecular Genetics, 21:3042-3049, 2012

1235. P.T. Ellinor, K.L. Lunetta, C.M. Albert, N.L. Glazer, M.D. Ritchie, A.V. Smith, D.E. Arking, M. Müller-Nurasyid, B.P. Krijthe, S.A. Lubitz, J.C. Bis, M.K. Chung, K. Ozaki, J.D. Roberts, J.G. Smith, A. Pfeufer, M.F. Sinner, K. Lohman, J. Ding, N.L. Smith, J.D. Smith, M. Rienstra, K.M. Rice, D.R. Van Wagoner, J.W. Magnani, R. Wakili, S. Clauss, J.I. Rotter, G. Steinbeck, L.J. Launer, R.W. Davies, M. Borkovich, T.B. Harris, H. Lin, U. Völker, H. Völzke, D.J. Milan, A. Hofman, E. Boerwinkle, L.Y. Chen, E.Z. Soliman, B.F. Voight, G. Li, A. Chakravarti, M. Kubo, U. Tedrow, L.M. Rse, P.M. Ridker, D. Conen, T. Tsunoda, T. Furukawa, N. Sotoodehnia, S. Xu, N. Kamatani, D. Levy, Y. Nakamura, B. Parvez, S. Mahida, K.L. Furie, J. Rosand, R. Muhammad, B.M. Psaty, T. Meitinger, S. Perz, H.-E. Wichmann, J.C.M. Witteman, W.H.L. Kao, S. Kathiresan, D.M. Roden, A.G. Uitterlinden, F. Rivadeneira, B. McKnight, M. Sjögren, A.B. Newman, Y. Liu, M.H. Gollob, O. Melander, T. Tanaka, B.H.C. Stricker, S.B. Felix, A. Alonso, D. Darbar, J. Barnard, D.I. Chasman, S.R. Heckbert, E.J. Benjamin, V. Gudnason, and S. Kääb: Meta analysis identifies six new susceptibility loci for atrial fibrillation. Nature Genetics, 44:670-688, 2012

1236. R. Osawa, T. Tsunoda, S. Yoshimura, T. Watanabe, M. Miyazawa, M. Tani, K. Takeda, H. Nakagawa, Y. Nakamura, and H. Yamaue: Identification of HLA-A24-restricted novel T cell epitope peptides derived from P-cadherin and kinesin family member 20A. Journal of Biomedicine and Biotechnology, :doi:10.1155/2012/848042, 2012

1237. M. Takawa, H.-S. Cho, S. Hayami, G. Toyokawa, M. Kogure, Y. Yamane, Y. Iwai, K. Maejima, K.

Ueda, A. Masuda, N. Dohmae, H.I. Field, T. Tsunoda, T. Kobayashi, T. Akasu, M. Sugiyama, S. Ohnuma, Y. Atomi, B.A.J. Ponder, Y. Nakamura, and R. Hamamoto: Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression. Cancer Research, 72:3217-3227, 2012

1238. H.-S. Cho, S. Hayami, G. Toyokawa, K. Maejima, Y. Yamane, T. Suzuki, N. Dohmae, M. Kogure, D. Kang, D.E. Neal, B.A.J. Ponder, H. Yamaue, Y. Nakamura, and R. Hamamoto: RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation. Neoplasia, 14:476-, 2012

1239. A. Fujimoto, Y. Totoki, T. Abe, K. A. Boroevich, F. Hosoda, H. H. Nguyen, M. Aoki, N. Hoshono, M. Kubo, F. Miya, Y. Arai, H. Takahashi, T. Shirakihara, M. Nagasaki, T. Shibuya, K. Nakano, K. Watanabe-Makino, H. Tanaka, H. Nakamura, J. Kusuda, H. Ojima, K. Shimada, T. Okusaka, M. Ueno, Y. Shigekawa, Y. Kawakami, K. Arihiro, H. Ohdan, K. Gotoh, O. Ishikawa, S. Ariizumi, M. Yamamoto, T. Yamada, K. Chayama, T. Kosuge, H. Yamaue, N. Kamatani, S. Miyano, H. Nakagama, Y. Nakamura, T. Tsunoda, T. Shibata, and H. Nakagawa: Whole genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nature Genetics, 44:760-764, 2012

1240. W. Obara, R. Ohsawa, M. Kanehira, R. Takata, T. Tsunoda, K. Yoshida, K. Takeda, T. Katagiri, Y. Nakamura, T. Fujioka: Cancer peptide vaccine therapy developed from ongoantigens that were identified through genome-wide expression profile analysis for bladder cancer Japanese Journal of Clinical Oncology, 42:591-600, 2012

1241. K. Okuno, F. Sugiura, K. Itoh, Y. Yoshida, T. Tsunoda, Y. Nakamura: Recent advances in active specific cancer vaccine threatment for colorectal cancer Current Pharmacology and Biotechnology, 13:1439-1445, 2012

1242. A. Toyama, A. Suzuki, T. Shimada, C. Aoki, Y. Aoki, Y. Umino, Y. Nakamura, D. Aoki, and TA. Sato: Proteomic characterization of ovarian cancers identifying annexin-A4, phosphoserine aminotransferase, cellular retinoic acid-binding protein 2, and serpin B5 as histology-specific biomarkers. Cancer Science, 103:747-755, 2012

1243. Y. Okada, K. Shimane, Y. Kochi, T. Tahira, A. Suzuki, K. Higasa, A. Takahashi, T. Horita, T. Atsumi, T. Ishii, A. Okamoto, K. Fujio, M. Hirakata, H. Amano, Y. Kondo, S. Ito, K. Takada, A. Mimori, K. Saito, M. Kamachi, Y. Kawaguchi, K. Ikari, OW Mohammed, K. Matsuda, C. Terao, K. Ohmura, K. Myouzen, N. Hosono, T. Tsunoda, N. Nishimoto, T. Mimori, F. Matsuda, Y. Tanaka, T. Sumida, H. Yamanaka, Y. Takasaki, T. Koike, T. Horiuchi, K. Hayashi, M. Kubo, N. Kamatani, R. Yamada, Y. Nakamura, and K. Yamamoto: A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese. PLoS Genetics, 8:e1002455, 2012

1244. H. Ochi, CN. Hayes, H. Abe, Y. Hayashida, T. Uchiyama, N. Kamatani, Y. Nakamura, and K. Chayama: Toward the establishment of a prediction system for the personalized treatment of chronic hepatitis C. Journal of Infectious Diseases, 205:204-210, 2012

1245. Y. Okada, X. Sim, M. J. Go, C.-H. Chen, D. Gu, F. Takeuchi, A. Takahashi, S. Maeda, T. Tsunoda, P. Chen, S.-C. Lim1, T.-Y Wong, J. Liu1, T. L. Young, T. Aung, M. Seielstad, Y.-Y. Teo, Y. J. Kim, J.-Y. Lee, B.-G. Han, D. Kang, F.-J. Tsai, L.-C. Chang, S.-J. C. Fann, Y.-T. Chen, H. Mei, D. C. Rao, J. E. Hixson, S. Chen, T. Katsuya, M. Isono, T. Ogihara, J. C. Chambers, W. Zhang, J. S. Kooner, the KidneyGen consortium, the CKDGen consortium , E. Albrecht, the GUGC consortium , K. Yamamoto, M. Kubo, Y. Nakamura, N. Kamatani, N. Kato, J. He, J.-Y. Wu, Y. S. Cho, E.-S. Tai, and T. Tanaka: Genome-wide meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics, 44:904-909, 2012

1246. M.G. Dunlop, S.E. Dobbins, S.M. Farrington, A.M.Jones, C. Palles, N. Whiffin, A. Tenesa, S. Spain, P. Broderick, L.-Y. Ooi, E. Domingo, C. Smillie, M. Henrion, M. Frampton, L. Martin, G. Grimes, M. Gorman, C. Semple, Y.P. Ma, E. Barclay, J. Prendergast, J.-B. Cazier, B. Olver, S. Penegar, S. Lubbe, I. Chander, L.G. Carvajal-Carmona, S. Ballereau, A. Lloyd, J. Vijayakrishnan, L. Zgaga, I. Rudan, E. Theodoratou, The Colorectal Tumour Gene Identification (CORGI) Consortium, J.M. Starr, I. Deary, I. Kirac, D. Kovacevi, L.A. Aaltonen, L. Renkonen-Sinisalo, J.-P. Mecklin, K. Matsuda, Y. Nakamura, Y. Okada, S. Gallinger, D.J. Duggan, D. Conti, P. Newcomb, J. Hopper, M.A. Jenkins, F. Schumacher, G. Casey, D. Easton, M. Shah, P. Pharoah, A. Lindblom, T. Liu, The Swedish Low-Risk Colorectal Cancer Study Group, C. G Smith, H. West, J.P. Cheadle, The COIN Collaborative Group, R. Midgley, D.J. Kerr, H. Campbell, I.P. Tomlinson, and R.S. Houlston: Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. Nature Genetics, 44:770-777, 2012

1247. T. Masuzawa, Y. Fujiwara, K. Okada, A. Nakamura, S. Takiguchi, K. Nakajima, H. Miyata, M. Yamasaki, Y. Kurokawa, R. Osawa, K. Takeda, K. Yoshida, T. Tsunoda, Y. Nakamura, M. Mori, and Y. Doki: Phase I/II study of S-1 plus cisplatin combined with peptide vaccines for human vascular endothelial growth factor receptor 1 and 2 in patients with advanced gastric cancer. International Journal of Oncology, 41:1297-1304, 2012

1248. K. Kusakabe, N. Ide, Y. Daigo, T. Itoh, K. Higashino,Y. Okano, G. Tadano, Y. Tachibana, Y. Sato, M. Inoue, T. Wada, M. Iguchi, T. Kanazawa, Y. Ishioka, K. Dohi, S. Tagashira, Y. Kido, S.

Sakamoto, K. Yasuo, M. Maeda, T. Yamamoto, M. Higaki, T. Endoh, K. Ueda, T. Shiota, H. Murai, and Y. Nakamura: Diaminopyridine-based potent and selective MPS1 kinase inhibitors binding to an unusual flipped-peptide conformation. Medical Chemistry Letters, 3:560−564, 2012

1249. T. Fujitomo, Y. Daigo, K. Matsuda, K. Ueda, and Y. Nakamura: Critical function for nuclear envelope protein TMEM209 in human pulmonary carcinogenesis. Cancer Research, 72:4110-4118, 2012

1250. K. Shiraishi, H. Kunitoh, Y. Daigo, A. Takahashi, K. Goto, H. Sakamoto, S. Ohnami, Y. Shimada, K. Ashikawa, A. Saito, S. Watanabe, K. Tsuta, N. Kamatani, T. Yoshida, Y. Nakamura, J. Yokota, M. Kubo, and T. Kohno: A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nature Genetics, 44:900-903, 2012

1251. M.-H. Nguyen, K. Ueda, Y. Nakamura, and Y. Daigo: Identification of a novel oncogene MMS22L involved in lung and esophageal carcinogenesis. International Journal of Oncology, 41:1285-1296, 2012

1252. K. Kono , H. Iinuma, Y. Akutsu, H. Tanaka, N. Hayashi, Y. Uchikado, T. Noguchi, H. Fujii, K. Okinaka, R. Fukushima, H. Matsubara, M. Ohira, H. Baba, S. Natsugoe, S. Kitano, K. Yoshida, T. Tsunoda, and Y. Nakamura: Multicenter, Phase II clinical trial of Cancer Vaccination for Advanced Esophageal cancer with Three Peptides derived from Novel Cancer-Testis Antigens. Journal of Trasnlational Medicine, 10:141, 2012

1253. B. E. Himes, X. Jiang, R. Hu, A. C. Wu, J. A. Lasky-Su, B. J. Klanderman, J. Ziniti, J. Senter-Sylvia, J. J. Lima, C. G. Irvin, S. P. Peters, D. A. Meyers, E. R. Bleecker, M. Kubo, M. Tamari, Y. Nakamura, S. J. Szefler, R. F. Lemanske Jr., R. S. Zeiger, R. C. Strunk, F. D. Martinez, J. P. Hanrahan, G. H. Koppelman, D. S. Postma, M. A. E. Nieuwenhuis, J. M. Vonk, R. A. Panettieri Jr., A. Markezich, E. Israel, V. J. Carey, K. G. Tantisira, A. A. Litonjua, Q. Lu, and S. T. Weiss: Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. PLoS Genetics, 8:e1002824, 2012

1254. M. Takahashi, Y. Furukawa, H. Shimodaira, M. Sakayori, T. Moriya, Y. Moriya, Y. Nakamura. and C. Ishioka: Aberrant splicing caused by a MLH1 splice donor site mutation found in a young Japanese patient with Lynch syndrome Familial Cancer, 11:559-564, 2012

1255. Y. Ji, J. M. Biernacka, S. Hebbring, Y Chai, G. D. Jenkins, A. Batzler, K. A. Snyder, M. S. Drews, Z. Desta, D. Flockhart, T. Mushiroda, M. Kubo, Y. Nakamura, N. Kamatani, D. Schaid, R. M. Weinshilboum and D. A. Mrazek: Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics. Pharmacogenomics Journal, :doi:10.1038/tpj.2012.32, 2012

1256. R. M. Baldwin, K. Owzar, H. Zembutsu, A. Chhibber, M. Kubo, C. Jiang, D. Watson, R. J. Eclov, J. Mefford, H. L. McLeod, P. N. Friedman, C. A. Hudis, E. P. Winer, E. M. Jorgenson, J. S. Witte, L. N. Shulman, Y. Nakamura, M. J. Ratain and D. L. Kroetz: A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101. Clinical Cancer Research, 18:5099-5109, 2012

1257. T.Hirota, A. Takahashi, M. Kubo, T. Tsunoda, K. Tomita, M. Sakashita, T. Yamada, S. Fujieda, S. Tanaka, S. Doi, A. Miyatake, T. Enomoto, C. Nishiyama, N. Nakano, K. Maeda, K. Okumura, H. Ogawa, S. Ikeda, E. Noguchi, T. Sakamoto, N. Hizawa, K. Ebe, H. Saeki, T. Sasaki, T. Ebihara, M. Amagai, S. Takeuchi, M. Furue, Y. Nakamura, and M. Tamari: Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. Nature Genetics, 44:1222-1226, 2012

1258. V. Kumar, P.H.Y. Lo, H. Sawai, N.Kato, A. Takahashi, Z. Deng, Y. Urabe, H. Mbarek, K. Tokunaga, Y. Tanaka, M. Sugiyama, M. Mizokami, R. Muroyama, R. Tateishi, M. Omata, K. Koike, C. Tanikawa, N. Kamatani, M. Kubo, Y. Nakamura, and K. Matsuda Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma. Plos ONE, 7:e44743, 2012

1259. S. Elgazzar, H. Zembutsu, A. Takahashi, M. Kubo, F. Aki, K. Hirata, Y. Takatsuka, M. Okazaki, S. Ohsumi, T. Yamakawa, M. Sasa, T. Katagiri, Y. Miki, and Y. Nakamura: A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor positive breast cancer in Japanese. Journal of Human Genetics, :doi:10.1038/jhg.2012.108, 2012

1260. H.-S. Cho, T. Shimazu, G. Toyokawa, Y. Daigo, Y. Maehara, S. Hayami, A. Ito, K. Masuda, N. Ikawa, H. I. Field, E. Tsuchiya, S. Ohnuma, B. A.J. Ponder, M. Yoshida, Y. Nakamura, and R. Hamamoto: Enhanced HSP70 lysine 561 methylation promotes proliferation of cancer cells through activation of aurora kinase B. Nature Communications, 3:DOI: 10.1038/ncomms2074, 2012

1261. S. Akamatsu, A. Takahashi, R. Takata, M. Kubo, T. Inoue, T. Morizono, T. Tsunoda, N. Kamatani, C. A. Haiman, P. Wan, G. K. Chen, L. Le Marchand, L. N. Kolonel, B. E. Henderson, T. Fujioka, T. Habuchi, Y. Nakamura, O. Ogawa, and H. Nakagawa: Reproducibility, Performance, and Clinical Utility of a Genetic Risk Prediction Model for Prostate Cancer in Japanese. PLOS ONE, 7:e46454, 2012

1262. A. Toyama, H. Nakagawa, K. Matsuda, T. Sato, Y. Nakamura, and K. Ueda: Quantitative structural characterization of local N-glycan microheterogeneity in therapeutic antibodies by

energy-resolved oxonium ion monitoring. Analytical Chemistry, 84:9655-9662, 2012 1263. D.R. Nyholt, S.-K. Low, C.A. Anderson, J.N. Painter, S. Uno, A.P. Morris, S. MacGregor, S.D.

Gordon, A.K. Henders, N.G. Martin, J. Attia, E.G. Holliday, M. McEvoy, R.J. Scott, S.H. Kennedy, S.A. Treloar, S.A. Missmer, S. Adachi, K. Tanaka, Y. Nakamura, K.T. Zondervan, H. Zembutsu, and G.W. Montgomery: Multi-ethnic GWA meta-analysis identifies new endometriosis risk loci Nature Genetics, 44:1355-1359, 2012

1264. K.M. Giacomini, S.W. Yee, M.J. Ratain, R.M. Weinshilboum, N. Kamatani and Y. Nakamura: Pharmacogenomics and patient care: one size does not fit all. Science Translational Medicine, 4:153ps18, 2012

1265. R. Takata, K. Matsuda, J. Sugimura, W. Obara, T. Fujioka, K. Okihara, N. Takaha, T. Miki, S. Ashida, K. Inoue, C. Tanikawa, T. Shuin, S. Sasaki, Y. Kojima, K. Kohri, M. Kubo, M. Yamaguchi, Y. Ohnishi, and Y. Nakamura: Impact of four loci on serum tamsulosin hydrochloride concentration. Journal of Human Genetics, 58:21-26, 2012

1266. T. Fukawa, M. Ono, T. Matsuo, H. Uehara, T. Miki, Y. Nakamura, H. Kanayama, and T. Katagiri: DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription through its interaction with NPM1 in renal cell carcinomas. Cancer Research, 72:5867-5877, 2012

1267. E. Danese, M. Montagnana, J.A. Johnson, A.E. Rettie, C.F. Zambon, S.A. Lubitz, G. Suarez-Kurtz, L.H. Cavallari, L. Zhao, M. Huang, Y. Nakamura, T. Mushiroda, M.K. Kringen, P. Borgiani, C. Ciccacci, N.T. Au, T. Langaee, V. Siguret, M.-A. Loriot, H. Sagreiya, R.B. Altman, M.H.A. Shahin, S.A. Scott, S.I. Khalifa, B. Chowbay, I.M. Suriapranata, M. Teichert, B.H. Stricker, M. Taljaard, M.R. Botton, J.E. Zhang, M. Pirmohamed, X. Zhang, J.F. Carlquist, B.D. Horne, M.T.M. Lee, V. Pengo, G.C. Guidi, P. Minuz, and C. Fava: Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: systematic review and meta-analysis. Clinical Pharmacology & Therapeutics, 92:746-756, 2012

1268. M. Komatsu, T. Yoshimaru, T. Matsuo, K. Kiyotani, Y. Miyoshi, T. Tanahashi, K. Rokutan, R. Yamaguchi, A. Saito, S. Imoto, S. Miyano, Y. Nakamura, M. Sasa, M. Shimada, and T. Katagiri: Molecular features of triple negative breast cancers by genome-wide gene expression profiling analysis. International Journal of Oncology, :doi: 10.3892/ijo.2012.1744., 2012

1269. N. Franceschini, F.J. van Rooij, B.P. Prins, M.F. Feitosa, Karakas M, Eckfeldt JH, Folsom AR, Kopp J, Vaez A, Andrews JS, Baumert J, Boraska V, Broer L, Hayward C, Ngwa JS, Okada Y, Polasek O, Westra HJ, Wang YA, Del Greco M F, Glazer NL, Kapur K, Kema IP, Lopez LM, Schillert A, Smith AV, Winkler CA, Zgaga L; The LifeLines Cohort Study, Bandinelli S, Bergmann S, Boban M, Bochud M, Chen YD, Davies G, Dehghan A, Ding J, Doering A, Durda JP, Ferrucci L, Franco OH, Franke L, Gunjaca G, Hofman A, Hsu FC, Kolcic I, Kraja A, Kubo M, Lackner KJ, Launer L, Loehr LR, Li G, Meisinger C, Nakamura Y, Schwienbacher C, Starr JM, Takahashi A, Torlak V, Uitterlinden AG, Vitart V, Waldenberger M, Wild PS, Kirin M, Zeller T, Zemunik T, Zhang Q, Ziegler A, Blankenberg S, Boerwinkle E, Borecki IB, Campbell H, Deary IJ, Frayling TM, Gieger C, Harris TB, Hicks AA, Koenig W, O'Donnell CJ, Fox CS, Pramstaller PP, Psaty BM, Reiner AP, Rotter JI, Rudan I, Snieder H, Tanaka T, van Duijn CM, Vollenweider P, Waeber G, Wilson JF, Witteman JC, Wolffenbuttel BH, Wright AF, Wu Q, Liu Y, Jenny NS, North KE, Felix JF, Alizadeh BZ, Cupples LA, Perry JR, Morris AP. Discovery and Fine Mapping of Serum Protein Loci through Transethnic Meta-analysis. Am. J. Human Genetics, 91:744-753, 2012

1270. S. Chung, H. Suzuki, T. Miyamoto, N. Takamatsu, A. Tatsuguchi, K. Ueda, K. Kijima, Y. Nakamura and Y. Matsuo: Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Oncotarget, 3:1629-1640, 2012

1271. I. Cheng, G.K. Chen, H. Nakagawa, J. He, P. Wan, C.C. Laurie, J. Shen, X. Sheng, L.C. Pooler, A.H. Crenshaw, D.B. Mirel, A. Takahashi, M. Kubo, Y. Nakamura, Yusuke)7; A.A. Olama, S. Benlloch, J.L. Donovan, M. Guy, F.C. Hamdy, Z. Kote-Jarai, D.E. Neal, L.R. Wilkens, K.R. Monroe, D.O. Stram, K. Muir, R.A. Eeles, D. Easton, L.N. Kolonel, B.E. Henderson, L. LeMarchand, and C.A. Haiman; Evaluating genetic risk for prostate cancer among Japanese and Latinos. Cancer Epidemiology Biomarkers & Prevention, 21:2048-2058, 2012

1272. H. Sawai, N. Nishida, H. Mbarak, K. Matsuda, Y. Mawatari, M. Yamaoka, S. Hige, J.H. Kang, K. Abe, S. Mochida, M. Watanabe, M. Kurosaki, Y. Asahina, N. Izumi, M. Honda, S. Kaneko, E. Tanaka, K. Matsuura, Y. Itoh, E. Mita, M. Korenaga, K. Hino, Y. Murawaki, Y. Hiasa, T. Ide, K. Ito, M. Sugiyama, S.H. Ahn, K.H. Han, J.Y. Park, M.F. Yuen, Y. Nakamura, Y. Tanaka, M. Mizokami, and K. Tokunaga: No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations. BMC Medical Genetics, 13:DOI: 10.1186/1471-2350-13-47, 2012

1273. A. IIda, N. Hosono, M. Sano, T. Kamei, S. Oshima, T. Tokuda, M. Nakajima, M. Kubo, Y. Nakamura, and S. Ikegawa, Novel deletion mutations of OPTN in amyotrophic lateral sclerosis in Japanese: Neurobiology of aging, 8:1.843E+22, 2012

1274. M. Myouzen, Y. Kochi, Y. Okada, C. Terao, A. Suzuki, K. Ikari, T. Tsunoda, A. Takahashi, M. Kubo, A. Taniguchi, F. Matsuda, K. Ohmura, S. Momohara, T. Mimori, H. Yamanaka, N. Kamatani, R. Yamada, Y. Nakamura, and K. Yamamoto: Functional variants in NFKBIE and RTKN2 involved in activation of the NF-kappa B pathway are associated with rheumatoid arthritis in Japanese. PLos Genetics, 8::e1002949, 2012

1275. A. Köttgen, E. Albrecht, A. Teumer, V. Vitart, J. Krumsiek et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics, 45:145-154, 2013

1276. H.E. Wheeler, E.R. Gamazon, C. Wing, U.O. Njiaju, C. Njoku, R.M. Baldwin, K. Owzar, C. Jiang, D. Watson, I. Shterev, M. Kubo, H. Zembutsu, E. Winer, C. Hudis, L.N. Shulman, Y. Nakamura, M.J. Ratain, D.L. Kroetz, N.J. Cox, M.E. Dolan for the Cancer and Leukemia Group B: Integration of cell line and clinical trial genome-wide analyses implicates multiple loci in paclitaxel-induced peripheral neuropathy. Clinical Cancer Research, 19:491-499, 2013

1277. K. Yamazaki, J. Umeno, A. Takahashi, A. Hirano, T. A. Johnson, N. Kumasaka, T. Morizono, N. Hosono, T. Kawaguchi, M. Takazoe, T. Yamada, Y. Suzuki, H. Tanaka, S. Motoya, M. Hosokawa, Y. Arimura, Y. Shinomura, T. Matsui, T. Matsumoto, M. Iida, T. Tsunoda, Y. Nakamura, N. Kamatani and M. Kubo: A Genome-wide association study Identifies 2 susceptibility loci for Crohn’s disease in a Japanese population. Gastroenterology, 144:781-788, 2013

1278. E.T. Betcheva, A.G. Yosifova, T. Mushiroda, M. Kubo, A. Takahashi, S.K. Karachanak, I.T. Zaharieva, S.P. Hadjidekova, I.I. Dimova, R.V. Vazharova, D.S. Stoyanov, V.K. Milanova, T. Tolev, G. Kirov, N. Kamatani, D.I. Toncheva, and Y. Nakamura: Whole-genome-wide association study in the Bulgarian population reveals HHAT as schizophrenia susceptibility gene. Psychiatric Genetics, 23:11-19, 2013

1279. D. Kang, H.-S. Cho, G. Toyokawa, M. Kogure, Y. Yamane, Y. Iwai, S. Hayami, T. Tsunoda, H. I. Field, K. Matsuda, D. E. Neal, B. A.J. Ponder, Y. Maehara, Y. Nakamura, and R. Hamamoto: The Histone Methyltransferase Wolf-Hirschhorn Syndrome Candidate 1-like 1 (WHSC1L1) Is Involved in Human Carcinogenesis. Genes Chromosomes and Cancer, 52:126-139, 2013

1280. R. Nakano, T. Maekawa, H. Abe, Y. Hayashida, H. Ochi, T. Tsunoda, H. Kumada, N. Kamatani, Y. Nakamura and K. Chayama: Single-nucleotide polymorphisms in GALNT8 are associated with the response to interferon therapy for chronic hepatitis C. Journal of General Virology, 94:81-89, 2013

1281. Y. Kamada, N. Kinoshita , Y. Tsuchiya, K. Kobayashi, H. Fujii, N. Terao, K. Kamihagi, N. Koyama, S. Yamada, Y. Daigo, Y. Nakamura, N. Taniguchi, E. Miyoshi: Reevaluation of a lectin antibody ELISA kit for measuring fucosylated haptoglobin in various conditions. Clinica Chimica Acta, 417:48-53, 2013

1282. K. Shimane, Y. Kochi, A. Suzuki, Y. Okada, T. Ishii, T. Horita, K. Saito, A. Okamoto, N. Nishimoto, K. Myouzen, M. Kubo, M. Hirakata, T. Sumida, Y. Takasaki, R. Yamada, Y. Nakamura, N. Kamatani and K. Yamamoto: An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes. Rheumatology, 52:1172-1182, 2013

1283. Y. Urabe, H. Ochi, N. Kato, V. Kumar1, A. Takahashi, R. Muroyama, N. Hosono3, M. Otsuka, R. Tateishi, P. H. Y. Lo, C. Tanikawa, M. Omata, K. Koike, D. Miki, H. Abe, N. Kamatani, J. Toyota, H. Kumada, M. Kubo, K. Chayama, Y. Nakamura, and Koichi Matsuda: A genome-wide association study of HCV induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at MHC region. Journal of Hepatology, 58:875-882, 2013

1284. A. Aarnink, H.J. Garchon, Y. Okada, T. Takahashi, K. Matsuda, M. Kubo, Y. Nakamura, and B, Blancher: Comparative analysis in cynomolgus macaque identifies a novel human MHC locus controlling platelet blood counts independently of BAK1. Journal of Thrombosis and Haemostasis, 11:384-386, 2013

1285. M. Unoki, A. Masuda, N. Dohmae, K. Arita, M. Yoshimatsu, Y. Iwai, Y. Fukui, K. Ueda, R. Hamamoto, M. Shirakawa, H. Sasaki, and Y. Nakamura: Lysyl 5-Hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6). Journal of Biological Chemistry, 288:6053-6062. , 2013

1286. K. Tomita, M. Sakashita, T. Hirota, S. Tanaka, K. MasuyamaT. Yamada, S. Fujieda, A. Miyatake, N. Hizawa, M. Kubo, Y. Nakamura, and M. Tamari: Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population. Allergy, 68:92-100, 2013

1287. Y. Kajita, T. Kato Jr, S. Tamaki, M. Furu, R. Takahashi, S. Nagayama, T. Aoyama, H. Nishiyama, E. Nakamura, T. Katagiri, Y. Nakamura, O. Ogawa, and J. Toguchida: The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1 (AFAP1L1). PLOS ONE, 8:e49709, 2013

1288. B. E. Himes, K. Sheppard, A. Berndt5, A. S. Leme, R. A. Myers, C. R. Gignoux, A. M. Levin8, W. J. Gauderman, J. J. Yang, R. A. Mathias, I. Romieu, D. G. Torgerson, L. A. Roth, S. Huntsman, C. Eng, B. Klanderman, J. Ziniti, J. Senter-Sylvia, S. J. Szefler, R. F. Lemanske, Jr., R. S. Zeiger, R. C. Strunk, F. D. Martinez, H. Boushey, V. M. Chinchilli, E. Israel, D. Mauger, G. H. Koppelman, D. S. Postma, M. A. E. Nieuwenhuis, J. M. Vonk, J. J. Lima, C. G. Irvin, S. P. Peters, M. Kubo, M. Tamari, Y. Nakamura, A. A. Litonjua, K. G. Tantisira, B. A. Raby, E. R. Bleecker, D. A. Meyers, S. J. London, K. C. Barnes, F. D. Gilliland, L. K. Williams, E. G. Burchard, D. L. Nicolae, C. Ober, D. L. DeMeo, E. K. Silverman, B. Paigen, G. Churchill, S. D. Shapiro, and S. T. Weiss: Integration of Mouse and Human Genome-wide association data identifies KCNIP4 as an asthma gene. PLOS ONE, 8:e56179, 2013

1289. The AMD Gene Consortium: Seven new loci associated with age-related macular degeneration.

Nature Genetics, 45:422-439, 2013 1290. K. Semba, K. Araki, K. Matsumoto, H. Suda, T. Ando, A. Sei, H. Mizuta, K. Takagi, M. Nakahara,

M. Muta, G. Yamada, N. Nakagata, A. Iida, S. Ikegawa, Y. Nakamura, M. Araki, K. Abe, and K. Yamamura: Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth’s short tail mice. PLOS Genetics, 9:e1003204, 2013

1291. A, Hirano, K. Yamazaki, J. Umeno, K. Ashikawa, M. Aoki, T. Matsumoto, S. Nakamura, T. Ninomiya, T. Matsui, F. Hirai, T. Kawaguchi, M. Takazoe, H. Tanaka, S. Motoya, Y. Kiyohara, T. Kitazono, Y. Nakamura, N. Kamatani, and M. Kubo: Associatiion study of 71 European Crohn's disease susceptibility loci in a Japanese population. Inflammatory Bowel Diseases, 19:526–533, 2013

1292. P.H.Y. Lo, Y. Urabe, V. Kumar, C. Tanikawa, K. Koike, N. Kato, D. Miki, K. Chayama, M. Kubo, Y. Nakamura, and K. Matsuda: Identification of a functional variant in the MICA promoter which regulates MICA expression and increases HCV-related hepatocellular carcinoma risk. PLOS ONE, 8:DOI: 10.1371/journal.pone.0061279, 2013

1293. M. A. Perera, L. H. Cavallari, N. A. Limdi, E. R. Gamazon, A. Konkashbaev, R. Daneshjou, A. Pluzhnikov, D. C. Crawford, J. Wang, N. Liu, N. Tatonetti, S. Bourgeois, H. Takahashi, Y. Bradford, B. M. Burkley, R. J. Desnick, J. L. Halperin, S. I. Khalifa, T. Y. Langaee, S. A. Lubitz, E. A. Nutescu, M. Oetjens, M. H. Shahin, S. R. Patel, H. Sagreiya, M. Tector, K. E. Weck, M. J. Rieder, S. A. Scott, A. H.B. Wu, J. K. Burmester, M. Wadelius, P. Deloukas, M. J. Wagner, T. Mushiroda, M. Kubo, D. M. Roden, N. J. Cox, R. B. Altman, T. E. Klein, Y. Nakamura, J. A. Johnson: Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. Lancet, 382:790-796, 2013

1294. M. Ishihara, N. Araya, T. Sato, A. Utsunomiya, Y. Yamano, Y. Nakamura, H. Nakagawa, and K. Ueda: Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia. Blood, 121:4340-4347, 2013

1295. M. Liu, J. N. Ingle, B. L. Fridley, A. U. Buzdar, M. E. Robson, M. Kubo, L. Wang, A. Batzler, G. D. Jenkins, T. L. Pietrzak, E. E. Carlson, M. P. Goetz, D. W. Northfelt, E. A. Perez, C. V. Williard, D. J. Schaid, Y. Nakamura and R. M. Weinshilboum: TSPYL5 SNPs: Association with Plasma Estradiol Concentrations and Aromatase Expression. Molecular Endocrinology, 27:657-670, 2013

1296. M. Ratain, Y. Nakamura, and N. J. Cox: CYP2D6 genotype and tamoxifen activity: Understanding interstudy variability in methodological quality. Clinical Pharmacology & Therapeutics, 94:185-187, 2013

1297. C. Tanikawa, C. Tanikawa, Y. Okada, A. Takahashi, K. Oda, N. Kamatani, M. Kubo, Y. Nakamura, and K. Matsuda: Genome wide association study of age at menarche in the Japanese population. PLOS ONE, 8:e63821, 2013

1298. M. Kogure, M. Takawa, H.-S. Cho, G. Toyokawa, K. Hayashi, T. Tsunoda, T. Kobayashi, Y. Daigo, M. Sugiyama, Y. Atomi, Y. Nakamura, and R. Hamamoto: Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G1/S transition Cancer Letters, 336:76-84, 2013

1299. J.N. Ingle, M. Liu, D.L. Wickerham, D.J. Schaid, L. Wang, T. Mushiroda, M. Kubo, J.P. Costantino, V.G. Vogel, S. Paik, M.P. Goetz, M.M. Ames, G.D. Jenkins, A. Batzler, E.E. Carlson, D.A. Flockhart, N. Wolmark, Y. Nakamura, and R.M. Weinshilboum: Selective Estrogen Receptor Modulators and Pharmacogenomic Variation in ZNF423 Regulation of BRCA1 Expression: Individualized Breast Cancer Prevention Cancer Discovery, 3:812-825, 2013

1300. S. Chung, and Y. Nakamura: MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells (editorial) Cell Cycle, 12:1655-1656, 2013

1301. K. Kiyotani, T. Mushirota, H. Zembutsu, and Y. Nakamura: Important and critical scientific aspects in pharmacogenomics analysis: lessons from controversial results of tamoxifen and CYP2D6 studies. Journal of Human Genetics, 58:327–333, 2013

1302. S.-K. Low , S. Chung, A. Takahashi, H. Zembutsu, T. Mushiroda, M. Kubo and Y. Nakamura: Genome-wide association study of chemotherapeutic agents-induced severe neutropenia/leucopenia for patients in Biobank Japan Cancer Science, 104:1074-1082, 2013

1303. T. Yasui, A. Okada, Y. Urabe, M. Usami, K. Mizuno, Y. Kubota, K. Tozawa, S. Sasaki, Y. Higashi, Y. Sato, M. Kubo, Y. Nakamura, K. Matsuda, and K. Kohri: A replication study for 3 nephrolithiasis loci at 5q35.3, 7p14.3, and 13q14.1 in the Japanese population. Journal of Human Genetics, 58:588-593, 2013

1304. Y. Daigo, A. Takano, K. Teramoto, S. Chung, and Y. Nakamura: A Systematic Approach to the Development of Novel Therapeutics for Lung Cancer using Genomic Analyses Clinical Pharmacology & Therapeutics, 94:doi:10.1038/clpt.2013.90, 2013

1305. H. Oshita, R. Nishino, A. Takano, T. Fujitomo, M. Aragaki, T. Kato, H. Akiyama, E. Tsuchiya, N. Kohno, Y. Nakamura, and Y. Daigo: RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer. Molecular Cancer Research, 11:937-951, 2013

1306. Y. Tomita, A. Yuno, H. Tsukamoto, S. Senju, Y. Kuroda, M. Hirayama, A. Irie, K. Kawahara, J. Yatsuda, A. Hamada, H. Jono, K. Yoshida, T. Tsunoda, H. Kohrogi, Y. Yoshitake, Y. Nakamura, M. Shinohara, and Y. Nishimura; Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant

tumor. Clinical Cancer Research, 19:4508-4520, 2013 1307. K. Kusakabe, N. Ide, Y. Daigo, Y. Tachibana, T. Itoh, T. Yamamoto, H. Hashizume, Y. Hato, K.

Higashino, Y. Okano, Y. Sato, M. Inoue, M. Iguchi, T. Kanazawa, Y. Ishioka, K. Dohi, Y. Kido, S. Sakamoto, K. Yasuo, M. Maeda, M. Higaki, K. Ueda, H. Yoshizawa, Y. Baba, T. Shiota, H. Murai, and Y. Nakamura: Indazole-based Potent and Cell-Active Mps1 Kinase Inhibitors: Rational Design from Pan-Kinase Inhibitor Anthrapyrazolone (SP600125). Journal of Medicinal Chemistry, 56:4343-4356, 2013

1308. H. Saeki, T. Hirota, H. Nakagawa, Y. Tsunemi, T. Kato, S. Shibata, M. Sugaya, S. Sato, S. Doi, A. Miyatake, K. Ebe, E. Noguchi, T. Ebihara, M. Amagai, H. Esaki, S. Takeuchi, M. Furue, Y. Nakamura, and M. Tamari: Genetic polymorphisms in the IL22 gene are associated with psoriasis vulgaris in a Japanese population. Journal of Dermatological Science, :doi.org/10.1016/j.jdermsci.2013.04.002, 2013

1309. D. Ellinghaus, H. Baurecht, J. Esparza-Gordillo, E. Rodríguez, A. Matanovic, I. Marenholz, N. Hübner, H. Schaarschmidt, N. Novak, S. Michel, L. Maintz, T. Werfel, U. Meyer-Hoffert, M. Hotze, H. Prokisch, K. Heim, C. Herder, T. Hirota, M. Tamari, M. Kubo, A. Takahashi, Y. Nakamura, L. C. Tsoi, P. Stuart, J.T. Elder, L. Sun, X. Zuo, S. Yang, X. Zhang, P. Hoffmann, M. MNöthen, R. Fölster-Holst, J. Winkelmann, T. Illig, B. OBoehm, R. H Duerr, C. Büning, S. Brand, J. Glas, M. A. McAleer, C. M. Fahy, M. Kabesch, S. Brown, W.H.I. McLean, A. DIrvine, S. Schreiber, Y.-A. Lee4, A. Franke and S. Weidinger: High-density genotyping study identifies four new susceptibility loci for atopic dermatitis Nature Genetics, :doi:10.1038/ng.2642, 2013

1310. R. Daneshjou, N. P. Tatonetti, K. J. Karczewski, H. Sagreiya, S. Bourgeois, K. Drozda, J. K. Burmester, T. Tsunoda, Y. Nakamura, M. Kubo, M. Tector, N. A. Limdi, L. H. Cavallari, M. Perera, J. A. Johnson, T. E Klein and R. B. Altman: Pathway analysis of genome-wide data improves warfarin dose prediction. BMC Genomics, 14:doi:10.1186/1471-2164-14-S3-S11, 2013

1311. T. Yoshimaru, M. Komatsu, T. Matsuo, Y.-A. Chen, Y. Murakami, K. Mizuguchi, E. Mizohata, T. Inoue, M. Akiyama, R. Yamaguchi, S. Imoto, S. Miyano, Y. Miyoshi, M. Sasa, Y. Nakamura, and T. Katagiri: Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells. Nature Communications, 4:DOI: 10.1038/ncomms3443, 2013

1312. S. Chung, S.-K. Low, H. Zembutsu, A. Takahashi, M. Kubo, M. Sasa, and Y. Nakamura: A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Breast Cancer Research, 15:R81, 2013

1313. G. Pare, M. Kubo, J. B. Byrd, C. A. McCarty, A. Woodard-Grice, K. K. Teo, S. S. Anand, R L. Zuvich, Y. Bradford, S. Ross, Y. Nakamura, M. Ritchie and N. J. Brown: Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenetics and Genomics, 23:470-478, 2013

1314. K. Asano, T. Matsumoto, J. Umeno, A. Hirano, M. Esaki, N. Hosono, T. Matsui, Y. Kiyohara, Y. Nakamura, M. Kubo, and T. Kitazono: Impact of allele copy number of polymorphisms in FCGR3A and FCGR3B genes on susceptibility to ulcerative colitis. Inflammatory Bowel Diseases, 19:2061-2068, 2013

1315. M. A. Province, M. P. Goetz, H. Brauch, D. A. Flockhart, J. M. Hebert, R. Whaley, V. J. Suman, W. Schroth, S. Winter, H. Zembutsu, T. Mushiroda, W. G. Newman, M.-T. M. Lee, C. B. Ambrosone, M. W. Beckmann, J.-Y. Choi, A.-S. Dieudonné, P. A. Fasching, R. Ferraldeschi, L. Gong, E. Haschke-Becher, A. Howell, L. B. Jordan, U. Hamann, K. Kiyotani, P. Krippl, D. Lambrechts, A. Latif, U. Langsenlehner, W. Lorizio, P. Neven, A. T. Nguyen, B.-W. Park, C. A. Purdie, P. Quinlan, W. Renner, M. Schmidt, M. Schwab, J.-G. Shin, J. C. Stingl, P. Wegman, S. Wingren, A. H.B. Wu, E. Ziv, G. Zirpoli, A. M. Thompson, V. C. Jordan, Y. Nakamura, R. B. Altman, M. M. Ames, R. M. Weinshilboum, M. Eichelbaum, J. N. Ingle and T. E. Klein: CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-analysis of Heterogeneous Study Populations. Clinical Pharmacology & Therapeutics, 94:doi: 10.1038/clpt.2013.186, 2013

1316. S.-K. Low, A. Takahashi, K. Ashikawa, J. Inazawa, Y. Miki, M. Kubo, Y. Nakamura, and T. Katagiri: Genome-wide association study of breast cancer in the Japanese population. PLOS ONE, 8:e76463, 2013

1317. K. Ueda, A. Tatsuguchi, N. Saichi, A. Toyama, K. Tamura, M. Furihata, R. Takata, S. Akamatsu, M. Igarashi, M. Nakayama, T. Sato, O. Ogawa, T. Fujioka, T. Shuin, Y. Nakamura, and H. Nakagawa: Plasma low-molecular-weight proteome profiling identified neuropeptide-Y as a prostate cancer biomarker polypeptide. Journal of Proteome Research, 12:4497-4506, 2013

1318. J. Wang, L. G. Carvajal-Carmona, J.-H. Chu, A. G. Zauber, APC Trial Collaborators, M. Kubo, K. Matsuda, M. Dunlop, R. S. Houlston, O. M. Sieber, L. Lipton, P. Gibbs, N. G. Martin, G. W. Montgomery, J. P. Young, P. N. Baird, M. J. Ratain, Y. Nakamura, S. Weiss, I. Tomlinson, and M. M. Bertagnolli: Germline variants and advanced colorectal adenomas: adenoma Prevention with Celecoxib Trial Genomewide Association Study. Clinical Cancer Research, 19:6430-6437, 2013

1319. C. M. O’Seaghdha, C. M. O’Seaghdha, H. Wu, Q. Yang, K. Kapur, I. Guessous, A. M. Zuber, A. Kottgen, C. Stoudmann, A. Teumer, Z. Kutalik, M. Mangino, A. Dehghan, W. Zhang, G. Eiriksdottir, G. Li, T. Tanaka, L. Portas, L. M. Lopez, C. Hayward, K. Lohman, K. Matsuda, S. Padmanabhan, D. Firsov, R. Sorice, S. Ulivi, A. C. Brockhaus, M. E. Kleber, A. Mahajan, F. D. Ernst, V. Gudnason, L. J. Launer, A. Mace, E. Boerwinckle, D. E. Arking, C. Tanikawa, Y.

Nakamura, M. J. Brown, J.-M. Gaspoz, J.-M. Theler, D. S. Siscovick, B. M. Psaty, S. Bergmann, P. Vollenweider, V. Vitart, A. F. Wright, T. Zemunik, M. Boban, I. Kolcic, P. Navarro, E. M. Brown, K. Estrada, J. Ding, T. B. Harris, S. Bandinelli, D. Hernandez, A. B. Singleton, G. Girotto, D. Ruggiero, A. Pio d’Adamo, A. Robino, T. Meitinger, C. Meisinger, G. Davies, J. M. Starr, J. C. Chambers, B. O. Boehm, B. R. Winkelmann, J. Huang, F. Murgia, S. H. Wild, H. Campbell, A. P. Morris, O. H. Franco, A. Hofman, A. G. Uitterlinden, F. Rivadeneira, U. Volker, A. Hannemann, R. Biffar, W. Hoffmann, S.–Y. Shin, P. Lescuyer, H. Henry, C. Schurmann, The SUNLIGHT consortium, The GEFOS consortium, P. B. Munroe, P. Gasparini, N. Pirastu, M. Ciullo, C. Gieger, W. Marz, L. Lind, T. D. Spector, A. V. Smith, I. Rudan, J. F. Wilson, O. Polasek, I. J. Deary, M. Pirastu, L. Ferrucci, Y. Liu, B. Kestenbaum, J. S. Kooner, J. C. M. Witteman, M. Nauck, W. H. L. Kao, H. Wallaschofski, O. Bonny, C. S. Fox, M. Bochud: Meta-analysis of genome-wide association studies identifies six new loci for serum calcium concentrations. PLOS Genetics, 9:e1003796, 2013

1320. M. Kogure, M. Kogure, M. Takawa, V. Saloura, K. Sone, L. Piao, K. Ueda, R. Ibrahim, T. Tsunoda, M. Sugiyama, Y. Atomi, Y. Nakamura and R. Hamamoto: The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination. Neoplasia, 11:1251-1261, 2013

1321. E.R. Behr, M.D. Ritchie, T. Tanaka, S. Kaab, D.C. Crawford, P. Nicoletti, A. Floratos, M.F. Sinner, P.J. Kannankeril, A.A.M. Wilde, C.R. Bezzina, E. Schulze-Bahr, S. Zumhagen, P. Guicheney, N.H. Bishopric, V. Marshall, S. Shakir, C. Dalageorgou, S. Bevan, Y. Jamshidi, R. Bastiaenen, R.J. Myerburg, J.-J. Schott, A.J. Camm, G. Steinbeck, K. Norris, R.B. Altman, N.P. Tatonetti, S. Jeffery, M. Kubo, Y. Nakamura, Y. Shen, A.L. George, Jr., and D.M. Roden: Genome wide analysis of drug-Induced Torsades de Pointes: Lack of common variants with large effect sizes. PLOS ONE, 8:e78511, 2013

1322. D. Miki, H. Ochi, A. Takahashi, C.N. Hayes, Y. Urabe, H. Abe, T. Kawaoka, M. Tsuge, N. Hiraga, M. Imamura, Y. Kawakami, H. Aikata, S. Takahashi, N. Akuta, F. Suzuki, K. Ikeda, H. Kumada, Y. Karino, J. Toyota, T. Tsunoda, M. Kubo, N. Kamatani, Y. Nakamura, and K. Chayama: HLA-DQB1*03 confers susceptibility to chronic hepatitis C in Japanese: A genome-wide association study Plos ONE, 8e84226, 2013

1323. D. Kroetz, A. Chhibber, J. Mefford, E. Stahl, S. Pendergrass, R. Baldwin, K. Owzar, M. Li, E. Winer, C. Hudis, H. Zembutsu, M. Kubo, Y. Nakamura, H. McLeod, M. Ratain, L. Shulman, M. Ritchie, R. Plenge, and J. Witte: Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance). The Pharmacogenomics Journal, in press, 2014

1324. Y. Tomita, A. Yuno, H. Tsukamoto, S. Senju, S. Yoshimura, R. Osawa, Y. Kuroda, M. Hirayama, A. Irie, A. Hamada, H. Jono, K.Yoshida, T. Tsunoda, H. Kohrogi, Y. Yoshitake, Y. Nakamura, M. Shinohara, and Y. Nishimura: Identification of CDCA1 long peptides bearing both CD4+ and CD8+ T-cell epitopes: CDCA1-specific CD4+ T-cell immunity in cancer patients. International Journal of Cancer, 134:352–366, 2014

1325. S. Yoshimura, T. Tsunoda, R. Osawa, M. Harada, T. Watanabe, T. Hikichi, M. Katsuda, M. Miyazawa, M. Tani, M. Iwahashi, K. Takeda, T. Katagiri, Y. Nakamura, and H. Yamaue: Identification of an HLA-A2-restricted epitope peptide derived from hypoxia-inducible protein 2 (HIG2). PLoS ONE, 9:e85267, 2014

1326. K. Yamaguchi, R. Yamaguchi, N. Takahashi, T. Ikenoue, T. Fujii, M. Shinozaki, G. Tsurita, K. Hata, A. Niida, S. Imoto, S. Miyano, Y. Nakamura, and Y. Furukawa: Overexpression of Cohesion Establishment Factor DSCC1 through E2F in Colorectal Cancer. PLoS ONE, 9:e85750, 2014