CurriculumVitae ProfessorSylviaRichardsonPhDPersonalDetailsFullname ProfessorSylviaRichardsonNationality FrenchAddress MRCBiostatisticsUnit,InstituteofPublicHealth,University

ForvieSite,RobinsonWay,Cambridge,CB20SREmail sylvia.richardson@mrc‐bsu.cam.ac.ukWeb http://www.mrc‐bsu.cam.ac.uk/People/SRichardson.htmlCurrentPositionJune2012 AppointedtoaResearchChairinBiostatistics,Universityof

CambridgeApril2012 Director,MRCBiostatisticsUnit,CambridgeProfessionalExperience1974‐1977 Teachingassistant,MathematicsDepartment,Universityof

Nottingham(UK)1977‐1979 Lecturer,StatisticsDepartment,UniversityofWarwick(UK)1979‐1981 Researchassistant,INSERMUnité170(FR)1981‐1987 MaîtredeConférences,UniversitéRenéDescartes(FR)1987‐1992 ChargéedeRecherches,INSERM,U.170(FR)1992‐2000 DirecteurdeRecherches,INSERM,U.170(FR)‐Headof

Biostatisticsgroup.Jan2000 PromotedtoDirecteurdeRecherches,1stClass–(en

détachement)2000‐2012 ChairofBiostatistics,ImperialCollegeLondon2012‐Present ChairofBiostatistics,UniversityofCambridgeEducationalQualifications1978PhD (NottinghamUniversity)“Ergodicpropertiesofstoppingtime

transformations”1989 Doctoratd’EtatEsSciencesMathematiques(Universitéde

ParisSud–Orsay)“Processusspatialementdépendants:convergenceverslanormalité,testsd’associationetapplications”.

HonoursandAwards1998 ElectedtotheInternationalStatisticsInstitute2009 AwardedtheRoyalStatisticalSocietyGuymedalinSilver2009‐2014 AwardedaRoyalSocietyWolfsonResearchMeritaward2011 IMSMedallionLecturer2014 ElectedFellowoftheInternationalSocietyforBayesianAnalysis2015 ElectedFellowoftheInstituteofMathematicalStatisticsRecentGrants• PIBiostatisticsUnitQuinquennialReviewAward(April2013–March

2018)£13.7M• Co‐IMedicalResearchCouncilgrant“Asystemsbasedapproachto

integratinggeneticandlongitudinalomicsdatatosupportdiagnosisandpredictionofcommonchronicdisease”(SpectorPI)£159,300.2014‐2019

• PIMedicalResearchCouncilgrant“BayesianDiscoveryofRegressionStructures(BDRS):atoolkitforgeneticepidemiologyandintegrativegenomicsanalyses”£670,000.2011‐2014

• Co‐IMedicalResearchCouncilgrant“Toolsforcharacterisingmulti‐pollutantpatternsofexposure”(MolitorPI,Hansell,Richardson)£493,000.2010‐13

• PIINSERM/INCA,Modifiedlungcancerriskbymultipleexposuresatworkandenvironmentalriskfactorscombined,£123,261.2009‐12

PreviousKeyGrants PrincipalInvestigator(PI)onajointEPSRC‐BBSRCgrant£460,184.

“Flexibleclusteringofgeneexpressiondata”,incollaborationwithProfTAitman(CSC,Hammersmith)andProfP.J.GreenFRS(Mathematicsdepartment,BristolUniversity)(2003‐2007)

Co‐PIWellcomeTrust“BiologicalAtlasofInsulinResistance”(£67,270).PIforStatisticalAnalysisWorkPackage,(2004)

Co‐PIESRCResearchNode(PIProfNBest)“BayesianmethodsforcombiningmultipleindividualandaggregatedatasourcesinObservationalstudies(BIAS)”(£650,514)(2005‐2008).

Co‐PIESRCResearchNode(PIProfNBest)“BayesianmethodsforintegratingbiasmodelingandanalysisofmultipledatasourcesinObservationalstudies(BIASII)”(£1.2M).(2008‐2011).

PIMedicalResearchCouncilgrant£300,000“Strategyforanalysingepidemiologicaldatainvolvinggenetic,endogenous,environmentalfactorsandtheirinteractions”.(2007‐2010)

PIUKNationalResearchCouncil(BBSRC)grant£504,458“Bayesianmethodsformodellingandintegratingmetabolicdata”(2008‐2011)

Co‐InvestigatorintheUKNationalResearchCouncil(BBSRC)SystemsBiologyCentreatImperialCollege.

Co‐PIintheMRCCentreforEnvironmentandHealthatImperialCollege(2009‐2012).

PostdoctoralAssociates:LaurentLeblond(1995‐2000),ShaunSeaman(1999‐2001),JamesBennett(2001‐2002),AlexLewin(2002‐2008),AnneMetteHein(2003‐2006),NataliaBochkina(2003—2006),LeonardoBottolo(2005‐2008),ChrisJackson(2005‐2007),VirgilioGomez(2005‐2008),MartaBlangiardo(2005‐2009),MichaelPapathomas(2007–2009),SaraGeneletti(2005‐2009),JassyMolitor(2006‐2010),LawrenceMcCandless(2007‐2008),PhilipLi(2008‐2012),AlexinaMason(2009‐2012),GeorgiosPapageorgiou(2010–2013),SilviaLiverani(2011–2014),HabibSaadi(2012–2014),PaulNewcombe(2012‐present),CatalinaVallejos(2014‐present),GwenLeday(2014‐present),PaulKirk(2015‐present).ResearchStudentsCurrentlysupervising4PhDstudents.CompletedPhDs:AnnieMollie(1990),JFViel(1992),LaurenceWatier(1993),CecileChouquet(1998),IsabelleDeltour(1999),ValerieViallefont(2000),AngelaCrook(2004),AndrewBrown(2008),ArturoGonzales(2008),ManuelaZucknick(2009),AlexinaMason(2009),OliverRatmann(2010),ErnestTurro(2010),CedricGinestet(2011),JuanGonzales(2013).Supervised15MasterthesisstudentsinFrance(1981‐1999),2MasterthesisstudentsatImperial.AdvisoryPositionsChairoftheInstituteofMathematicalStatisticsCommitteeonSpecialLectures(2013‐2014)MemberoftheResearchCommitteeoftheHealthEffectsInstitute,Boston,US(2005‐2013)ConseilScientifiquedel’ANSES(AgenceFrançaisedeSécuritésanitairedel’alimentation,l’environnementetdutravail)(2010‐2018)

MemberofINSERMResearchEvaluationCommitteeCSS3Sciencesandtechniquesappliedtomedicineandpublichealth)(2008–2012)MemberoftheInternationalAdvisoryBoardoftheprogramme“StatisticsforInnovation,SFI”,UniversityofOslo(2009‐2014)MemberoftheScientificSteeringCommitteeoftheIsaacNewtonInstitute,Cambridge(2012‐2016).NominatedtotheNationalResearchAssessmentExercisePanelforStatistics(2006–2008)ConseilScientifiquedeL’AFSSET”(AgenceFrançaisedeSécuritésanitairedel’environnementetdutravail)(2006‐2010)HonorarySecretaryandThemeDirectorforPublicationattheRoyalStatisticalSocietyandMemberoftheExecutivecouncil(2003‐2006)ChairofthePublicationReviewworkingpartyoftheRoyalStatisticalSociety(2001‐2002)MemberofCounciloftheRoyalStatisticalSociety(1998‐2002)MemberoftheResearchSectionoftheRoyalStatisticalSociety(1995‐1998)Vice‐chairmanofEuropeanScienceFoundation(ESF)programme"HighlyStructuredStochasticSystems(HSSS)"(1997‐2000).ScientificsecretarytotheESFHSSSNetwork(1994‐1996)PresidentoftheInternationalSocietyforBayesianAnalysis(2005),Executivecommittee(2004‐2006)MemberofCounciloftheInternationalStatisticsInstitute(2001‐2004)MemberofCounciloftheInternationalBiometricSociety(1996‐1999)EditorialandRefereeingServicesAssociateEditorJournaloftheRoyalStatisticalSociety–SeriesB(1996–2001)AssociateEditorBiometrics(1997–2001)EditorialboardofStatisticsinMedicine(1993–1999)AssociateEditorBiostatistics(1999–2003)AssociateEditorInternationalStatisticsReview(2000–2003)EditorialBoardofAnnualReviewofStatisticsandItsApplication(2012‐present)Conferenceorganisation(from2000)ChairofScientificCommitteeoftheInternationalBiometricsConference,Berkeley,July2000.Co‐Organiser,InternationalWorkshop"ModelsandInferenceinHighlyStructuredStochasticSystems:RecentDevelopmentsandPerspectives”.CentreInternationaldeRecherchesMathematiquesatLuminy(France)November2000. ScientificCommittee,25thEuropeanMeetingofStatisticians(Oslo,July2005).

ScientificCommittee,RoyalStatisticalSocietyconferenceonStatisticalGeneticsandBioinformatics,Leuven,July2003Co‐Organiser,InternationalWorkshoponthe“StatisticalAnalysisofGeneexpressiondata”(co‐fundedbytheRoyalStatisticalSocietyandEPSRC),Wye(UK),July2003Organiser,Workshopon"DatafusioninGenomics",InstituteforMathematicalSciences,ImperialCollege(September2005)ProgrammeCommittee,8thWorldCongressinProbabilityandStatistics(BernoulliSocietyandIMS),Istanbul,July2012ChairofScientificCommitteeoftheMedicalResearchConferenceonBiostatisticsincelebrationoftheMRCBiostatisticsUnit’sCentenaryYear,Cambridge,March2014.SelectedInvitedConferencetalks(since2000)SpatialmixtureofPoissondistributions.ISBA6thWorldmeeting2000,Heraklion(Greece),June2000Spatialepidemiology,aperspective.RoyalStatisticalSociety2001SpatialModellingThemeConference,Glasgow(UK)July2001Bayesianmodellingofdifferentialgeneexpressiondata,InternationalWorkshoponBayesianDataAnalysis"SantaCruz(USA),August2003BayesianPartitionModelforCaseControlStudiesinvolvingHighly‐PolymorphicCandidateGenes.JointStatisticalMeetingASA‐IMS,SanFrancisco(USA),August2003Bayesianhierarchicalmodellingofgeneexpressiondata,"StatisticsinFunctionalGenomics"workshop,Ascona(Switzerland),2004.Bayesianhierarchicalmodellingofgeneexpressiondata.NUSInternationalWorkshoponStatisticalMethodsinMicroarrayAnalysis,Singapore,January2004BayesianHierarchicalModels:ApplicationsinEpidemiologyandPublicHealth.ISISatellitemeeting,Fukuoka(Japan),September2004Bayesianhierarchicalmodellingofgenomicdata,(Keynotetalk)2ndIMS‐ISBAjointmeetingBormio(Italy),January2005Bayesianhierarchicalmodellingofgenomicdata,"RecentadvancesinBiostatistics,BioinformaticsandMarkovChainMonteCarlo"Sydney(Australia),July2005.Bayesianhierarchicalmodelsinecologicalstudies.20thInternationalworkshoponStatisticalModelling,Sydney(Australia),July2005Bayesiananalysisofgeneexpressiondata.RecentAdvancesinStatisticalGeneticsandBioinformatics,IsaacNewtonInstituteforMathematicalSciences,Cambridge(UK),December2006Bayesianinferenceindifferentialexpressionexperiments,StatisticsforGeneandProteinExpressionWorkshop,Gothenburg(Sweden),May2006

FullyBayesianvariableselectionusingg‐priors.Bioinformatics,GeneticsandStochasticComputation:BridgingtheGap.BanffInternationalResearchStationworkshop,Banff(Canada),July2007MCMCmethodsforbuildingmolecularprofilesvialogisticregressionmodels,3rdIMS‐ISBAjointmeeting(Bormio,Italy),January2008Bayesiananalysisofhighdimensionaldata,9thWorldMeetingofISBA,Hamiltonislands(Australia),July2008Bayesiansparseregressionmodelsofhighdimensionaldata(Keynotetalk)LeedsAnnualStatisticalResearch(LASR)workshop,Leeds,July2009Introductiontospatialepidemiology:somemethodologicalissuesandrecentdevelopments.Atutoriallecture,WorkshopSAMSIprogramonSpace‐timeanalysisforEnvironmentalMapping,EpidemiologyandClimateChange,September2009.Bayesiangraphicalmodelsforcombiningmultipledatasources,withapplicationsinenvironmentalepidemiologyENARBiometrics2010Meeting,NewOrleans,March2010Bayesianmodelsforsparseregressionanalysisofhighdimensionaldata.9thValenciaInternationalMeetingonBayesianStatistics,Valencia(Spain),May2010.RecentdevelopmentsinBayesianstatisticalmethodsforgenomics,SpecialinvitedlectureEMSPiraeus2010Profile‐basedmodellinginenvironmentalandhealthstudies,4rdIMS‐ISBAjointmeeting,Utah(USA),January2011Bayesiansparseregressionmodelsofhighdimensionaldata(Keynotetalk).WorkshoponComputationalStatisticalMethodsforGenomicsandSystemsBiology,Centrederecherchesmathematiques(CRM),Montreal(Canada)April2011RecentdevelopmentsinBayesianmethodsfordiscoveringregressionstructures:applicationsinthehealthsciences.MedallionLecture(awardedbyIMS).JointStatisticalMeeting,MiamiBeach(USA),August2011Bayesianmethodsfordiscoveringregressionstructures:applicationsinthehealthsciences(Keynotetalk)StatistischeWoche,Vienna(Austria),September2012ApplicationofBayesiansparseregressionmodelsingenomics,BiometricsENARmeeting,Orlando,March2013.BiostatisticsandBayes,RoyalStatisticalSociety“250Bayes”anniversarymeeting,London,June2013Modellingapproachesinintegrativegenomics,BiometricsENARmeeting,Baltimore,March2014.Bayesianhierarchicalmodellingstrategiesinintegrativegenomics(Keynotetalk).12thWorldMeetingofISBA,Cancun,July2014Analysisofcomplexphenotypesingenomics(Keynotetalk)InternationalBiometricsSocietyChannelNetworkConference,Nijmegen,Netherlands,April2015

Publications(Journals,lettersanddiscussion,booksandchapters157 NewcombePJ,ContiDV,RichardsonS(2015).Anewandscaleable

Bayesianframeworkforjointre‐analysisofmarginalSNPeffects.GeneticEpidemiology39(7),572‐572.

156 LewinA,SaadiH,PetersJE,Moreno‐MoralA,LeeJC,SmithKG,PetrettoE,BottoloL&RichardsonS.MT‐HESS:anefficientBayesianapproachforsimultaneousassociationdetectioninOMICSdatasets,withapplicationtoeQTLmappinginmultipletissues.Bioinformatics(2015)doi:10.1093/bioinformatics/btv568

155 PapageorgiouG,RichardsonS&BestN(2015).Bayesiannon‐parametricmodelsforspatiallyindexeddataofmixedtype.JournaloftheRoyalStatisticalSocietySeriesB,77(5):973‐999.http://dx.doi.org/10.1111/rssb.12097

154 ChongHP,CordeauxY,RanjanYS,RichardsonS,LiquetB,SmithGC&Charnock‐JonesDS.Age‐relatedchangesinmurinemyometrialtranscriptprofilearemediatedbyexposuretothefemalesexhormones.AgingCell.2015;10.1111/acel.12406:n/a‐n/a.http://www.ncbi.nlm.nih.gov/pubmed/26490259

153.SLiverani,DIHastie,LAzizi,MPapathomas,&SRichardson.PReMiuM:AnRPackageforProfileRegressionMixtureModelsUsingDirichletProcesses.JournalofStatisticalSoftware,64(7):1‐30(2015)

152.CAVallejos,JCMarioni,&SRichardson.BASiCS:BayesianAnalysisofSingle‐CellSequencingData.PLoSComputBiol,11(6):e1004333(2015)

151.CWallace,…,SRichardson,AJCutler,LSWicker.DissectionofaComplexDiseaseSusceptibilityRegionUsingaBayesianStochasticSearchApproachtoFineMapping.PLoSGenetics,11(6):e1005272(2015)

150.SGeneletti,AGO'Keeffe,LDSharples,SRichardson,andGBaio,G.Bayesianregressiondiscontinuitydesigns:incorporatingclinicalknowledgeinthecausalanalysisofprimarycaredata.StatisticsinMedicine,34(15):2334‐2352(2015)

149.SKWestbury,ETurro,DGreene,...,WHOuwehand,SRichardson,AD

Mumford&KFreson.Humanphenotypeontologyannotationandclusteranalysistounravelgeneticdefectsin707caseswithunexplainedbleedingandplateletdisorders.GenomeMedicine,7(1):36doi:10.1186/s13073‐015‐0151‐5.eCollection(2015)

148.JBPettit,RTomer,KAchim,SRichardson,LAzizi&JMarioni.Identifyingcelltypesfromspatiallyreferencedsingle‐cellexpressiondatasets.PLoSComputationalBiology,10(9):e1003824(2014)

147.LChen,MKostadima,JH.A.Martens,GCanu,56authors,SRichardson,ACvejic,,NSoranzo,,WHOuwehand,HGStunnenberg,MFrontini&ARendon.Transcriptionaldiversityduringlineagecommitmentofhumanbloodprogenitors.Science,6:345(6204):1251033doi:10.1126/science.1251033(2014)

146.JMolitor,IBrown,QChan,MPapathomas,SLiverani,NTMolitor,S

Richardson,LVanHorn,MDaviglus,ADyer,JStamler,&PElliott.BloodpressuredifferencesassociatedwithOptimumMacronutrientIntakeTrialforHeartHealth(OMNIHEART)‐likedietcomparedwithatypicalAmericandiet.Hypertension,64(6):1198‐1204(2014)

145.PJNewcombe,HRazaAli,FMBlows,EProvenzano,PDPharoah,CCaldas

&SRichardson.WeibullregressionwithBayesianvariableselectiontoidentifyprognostictumourmarkersofbreastcancersurvival.StatisticsMethodsinMedicalResearch,doi:10.1177/0962280214548748(2014).

144.TTruong,BLiquet,FMenegaux,SPlancoulaine,PLaurent‐Puig,CMulot,

E.Cordina‐Duverger,MSanchez,PArveux,PKerbrat,SRichardson&PGuenel.Breastcancerrisk,nightwork,andcircadianclockgenepolymorphisms.Endocrine‐RelatedCancer,21:629–638,(2014)

143. DIHastie,SLiverani&SRichardson.SamplingfromDirichletprocess

mixturemodelswithunknownconcentrationparameters:mixingissuesinlargedataimplementations.StatisticsandComputing,doi10.1007/s11222‐014‐9471‐3(2014)

142.MChadeau‐Hyam,PTubert‐Bitter,CGuihenneuc‐Jouyaux,GCampanella,

SRichardson,RVermeulen,MDeIorio,SGalea,&PVineis.Dynamicsoftheriskofsmoking‐inducedlungcancer:acompartmentalhiddenMarkovmodelsforlongitudinalanalysis.Epidemiology,25(1):28‐34(2014)

141. DIHastie,SLiverani,LAzizi,SRichardsonandIStucker.Asemi‐

parametricapproachtoestimateriskfunctionsassociatedwithmultidimensionalexposureprofiles:applicationtosmokingandlungcancer.BMCMedicalResearchMethodology,13(1):129(2013)

140. ALHansell,MBlangiardo,LFortunato,coll.&SRichardson,PElliott.

AircraftnoiseandcardiovasculardiseasenearLondonHeathrowAirport.BritishMedicalJournal,347:f5432(2013)

139.LBottolo,MChadeau‐Hyam,coll.&SRichardson.GUESS‐ingpolygenic

associationswithmultiplephenotypesusingaGPU‐basedEvolutionaryStochasticSearchalgorithMPLoSGenetics,9(8):e1003657(2013)

138. PKirk,AWitkover,CRMBangham,SRichardson,AMLewin,MPHStumpf.

BalancingtheRobustnessandPredictivePerformanceofBiomarkers,JournalofComputationalBiology,20(10):1‐11(2013)

137. SGeneletti,NBest,MBToledano,PElliott&SRichardson.Uncoveringselectionbiasincase‐controlstudiesusingBayesianpost‐stratification.StatisticsinMedicine,32(15):2555‐2570(2013)

136. GLi,RHaining,SRichardson&NBest.EvaluatingtheNoColdCalling

zonesinPeterborough,England:applicationofanovelstatisticalmethodforevaluatingneighbourhoodpolicingpolicies.EnvironmentandPlanningA,45(8):2012‐2026(2013)

135. WAstle,MDeIorio,SRichardson,DStephens&TEbbels.ABayesian

ModelofNMRSpectrafortheDeconvolutionandQuantificationofMetabolitesinComplexBiologicalMixtures.JournaloftheAmericanStatisticalAssociation,107(500):1259‐1271(2012)

134. LMcCandless,SRichardson,NBest.AdjustmentforMissingConfounders

UsingExternalValidationDataandPropensityScores.JournaloftheAmericanStatisticalAssociation,107:40‐51(2012)

133. MPapathomas,JMolitor,CHoggart,DHastie,SRichardson.Exploring

DataFromGeneticAssociationStudiesUsingBayesianVariableSelectionandtheDirichletProcess:ApplicationtoSearchingforGene×GenePatterns.GeneticEpidemiology.36:663‐674(2012)

132. SAncelet,JJAbellan,VJDelRioVilas,CBirch,SRichardson.Bayesian

sharedspatial‐componentmodelstocombineandborrowstrengthacrosssparsediseasesurveillancesources.BiometricalJournal,54:385‐404(2012)

131. CPetit,MBlangiardo,SRichardson,FCoquet,CChevrier,SCordier.

AssociationofEnvironmentalInsecticideExposureandFetalGrowthWithaBayesianModelIncludingMultipleExposureSources:ThePELAGIEMother‐ChildCohort.AmJEpidemiol,175(11):1182‐1190(2012)

130. AMason,SRichardson,IPlewis,andNBest.Strategyformodellingnon‐

randommissingdatamechanismsinobservationalstudiesusingBayesianmethods.JournalofOfficialStatistics,28(2):279‐302(2012)

129. DGinestet,NBestandSRichardson.ClassificationLossFunctionfor

ParameterEnsemblesinBayesianHierarchicalModels.StatisticsandProbabilityLetters,82(4):859‐863(2012)

128. GLi,NBest,ALHansell,IAhmed,SRichardson.BaySTDetect:detecting

unusualtemporalpatternsinsmallareadataviaBayesianmodelchoice.Biostatistics,13(4):695‐710(2012)

127. AMason,SRichardsonandNBest.Two‐prongedStrategyforUsingDIC

toCompareSelectionModelswithNon‐IgnorableMissingResponses.BayesianAnalysis,7(1):109‐146(2012)

126. LCMcCandless,PGustafson,ARLevy,SRichardson.HierarchicalpriorsforbiasparametersinBayesiansensitivityanalysisforunmeasuredconfounding.StatisticsinMedicine.31:383‐396(2012)

125. SJClark,MFalchi,BOlsson,PJacobson,SCauchi,BBalkau,MMarre,O

Lantieri,JCAndersson,MJernås,TJAitman,SRichardson,LSjöström,HYWong,LMCarlsson,PFroguel,AJWalley.Associationofsirtuin1(SIRT1)geneSNPsandtranscriptexpressionlevelswithsevereobesity.Obesity(SilverSpring),20:178‐185(2012)

124. AJWalley,PJacobson,MFalchi,LBottolo,JCAndersson,E.Petretto,A

Bonnefond,EVaillant,CLecoeur,VVatin,MJernas,DBalding,MPetteni,YSPark,TAitman,SRichardson,LSjostrom,LMSCarlssonandPFroguel.Differentialco‐expressionanalysisofobesity‐associatednetworksinhumansubcutaneousadiposetissue.InternationalJournalofObesity,36:137‐147(2012)

123. IAhmed,ALHartikainen,MJJarvelin,andSRichardson.FalseDiscovery

RateestimationforStabilitySelection:ApplicationtoGenome‐Wideassociationstudies.StatisticalApplicationsinGeneticsandMolecularBiology,10(1),1544‐6115(2011)

122. LBottolo,EPetretto,SBlankenberg,FCambien,SACook,LTiret,S

Richardson.Bayesiandetectionofexpressionquantitativetraitlocihotspots.Genetics,189:1449‐1459(2011)

121. JMolitor,JGSu,NTMolitor,VGRubio,SRichardson,DHastie,RMorello‐

Frosch,MJerrett.Identifyingvulnerablepopulationsthroughanexaminationoftheassociationbetweenmultipollutantprofilesandpoverty.EnvironSciTechnol,45:7754‐7760(2011)

120. PDKirk,AWitkover,ACourtney,AMLewin,RWait,MPStumpf,S

Richardson,GPTaylor,CRBanghaM.PlasmaproteomeanalysisinHTLV‐1‐associatedmyelopathy/tropicalspasticparaparesis.Retrovirology,8(1):1‐9(2011)

119. AABrown,SRichardson,J.Whittaker.ApplicationoftheLassoto

ExpressionQuantitativeTraitLociMapping.StatisticalApplicationsinGeneticsandMolecularBiology,10(1):1‐35(2011)

118. LBottolo,MChadeau‐Hyam,DIHastie,SRLangley,EPetretto,LTiret,D

TregouetandSRichardson.ESS++:aC++objected‐orientedalgorithmforBayesianstochasticsearchmodelexploration,Bioinformatics,27:587‐588(2011)

117. E.Turro,SYSu,A.Goncalves,LJMCoin,SRichardson,ALewin.

Haplotypeandisoformspecicexpressionestimationusingmulti‐mappingRNA‐seqreads.GenomeBiology,12:R13(2011)

116. LFortunato,JJAbellan,LBeale,SLeFevre,SRichardson.Spatio‐temporalpatternsofbladdercancerincidenceinUtah(1973‐2004)andtheirassociationwiththepresenceoftoxicreleaseinventorysites.IntJHealthGeog,.10:16,(2011)

115. MBlangiardo,SRichardson,A.HansellandJ.Gulliver.Bayesiananalysis

oftheimpactofairpollutionepisodesoncardio‐respiratoryhospitaladmissionsintheGreaterLondonarea,StatisticalMethodsinMedicalResearch,20:69‐80(2011)

114. MBlangiardo,A.HansellandSRichardson.ABayesianmodeloftime

activitydatatoinvestigatehealtheffectofairpollutionintimeseriesstudies.AtmosphericEnvironment,45(2):379‐386(2011)

113. Vilas,VJDelRio,SAncelet,JJAbellan,CPDBirch,andSRichardson.A

Bayesianhierarchicalanalysistocompareclassicalandatypicalscrapiesurveillancedata,Wales2002‐2006PrevVetMed,98(1):29‐36(2011)

112. MPapathomas,JMolitor,SRichardson,ERiboliandPVineis.Examining

thejointeffectofmultipleriskfactorsusingexposureriskprofiles:lungcancerinnonsmokers.EnvironmentalHealthPerspectives,119:84‐91(2011)

111. LBottoloandSRichardson.EvolutionaryStochasticSearchforBayesian

modelexploration.BayesianAnalysis,5(3):583—618(2010)110. MBlangiardo,ACasseseandSRichardson.Sdef:anRpackageto

synthesizelistsofsignificantfeaturesinrelatedexperiments.BMCBioinformatics.11:270doi:10.1186/1471‐2105‐11‐270,(2010)

109. EPetretto,LBottolo,SRLangley,MHeining,CMcDermott‐Roe,RSarwar,

MPravenec,NHübner,TJAitman,SACook,SRichardson.NewInsightsintotheGeneticControlofGeneExpressionusingaBayesianMulti‐tissueApproach.PLoSComputBiol,6(4):e1000737,(2010)

108. RHaining,GQLi,RMaheswaran,MBlangiardo,JLaw,SRichardson&N

Best.Inferencefromecologicalmodels:estimatingtherelativeriskofstrokefromairpollutionexposureusingsmallareadata.SpatialandSpatio‐temporalEpidemiology,1:123‐131,(2010)

107. JTMolitor,MMPapathomas,JerrettandSRichardson.BayesianProfile

RegressionwithanApplicationtotheNationalSurveyofChildren'sHealth,Biostatistics,11:484‐498,(2010)

106. AJWPaige,MZucknick,SJanczar,JPaul,CAMein,KJTaylor,MStewart,C

Gourley,SRichardson,TPerren,TSGanesan,JFSmyth,RBrown,FBalkwill,andHGabra.WWOXTumourSuppressorGenePolymorphismsandOvarianCancerPathologyandPrognosis,EuropeanJournalofCancer,46(4):818‐25(2010).

105. PGustafson,LCMcCandless,ARLevyandSRichardson.Simplified

Bayesiansensitivityanalysisformismeasuredandunobservedconfounders,Biometrics,66(4),1129‐1137,(2010).

104. ETurro,ALewin,ARose,MJDallman,SRichardson.MMBGX:amethod

forestimatingexpressionattheisoformlevelanddetectingdifferentialsplicingusingwhole‐transcriptAffymetrixarrays.NucleicAcidsRes,38:e4‐e4(2010)

103. PBroet,PTan,MAlifano,SCamilleri‐Broet,andSRichardson.Finding

exclusivelydeletedoramplifiedgenomicareasinlungadenocarcinomasusinganovelchromosomalpatternanalysis.BMCMedicalGenomics,2:43(2009).

102. SRichardsonandC.Guihenneuc‐Jouyaux.ImpactofCliffandOrd

(1969,1981)onSpatialEpidemiologyGeographicalAnalysis,41(4):444‐451(2009).

101. SGoria,CDaniau,PdeCrouy‐Chanel,PEmpereur‐Bissonnet,PFabre,M

Colonna,CDuboudin,JFViel,SRichardson.Riskofcancerinthevicinityofmunicipalsolidwasteincinerators:importanceofusingaflexiblemodellingstrategy.IntJHealthGeographics.8(1):31(2009)

100. ORatmann,CAndrieu,CWiuf,SRichardson.Modelcriticismbasedon

likelihood‐freeinference,withanapplicationtoproteinnetworkevolution.ProcNatlAcadSciUS,106(26):10576‐10581(2009)

99. NTMolitor,NBest,CJackson,SRichardson.UsingBayesiangraphical

modelstomodelbiasesinobservationalstudiesandtocombinemultiplesourcesofdata:applicationtolowbirthweightandwaterdisinfectionby‐products.JournaloftheRoyalStatisticalSociety,SeriesA:StatisticsInSociety,172:615‐637(2009)

98. SGeneletti,NBestandSRichardson.Adjustingforselectionbiasin

retrospectivecasecontrolstudies,.Biostatistics,10(1):17‐31(2009)97. PElliott,SRichardson,J.J.Abellan,A.Thomson,DBriggs,CdeHoogh,L

Jarup.GeographicdensityoflandfillsitesandriskofcongenitalanomaliesinEngland,OccupationalandEnvironmentalMedicine,66:81‐89(2009)

96. CJackson,NBestandSRichardson.Bayesiangraphicalmodelsfor

regressiononmultipledatasetswithdifferentvariablesBiostatistics,10(2):335‐351(2009)

95. MBlangiardoandSRichardson.ABayesiancalibrationmodelfor

combiningdifferentpre‐processingmethodsinAffymetrixchips,BMCBioinformatics,9:512.(2008)

94 CJackson,SRichardsonandNBest.Studyingplaceeffectsonhealthbysynthesisingindividualandarea‐leveloutcomesSocialScience&Medicine,67:1995‐2006(2008)

93. JJAbellan,SRichardsonandNBest.UseofSpace‐timeModelsto

InvestigatetheStabilityofPatternsofDiseaseEnvironHealthPerspect,116:1111–1119(2008)

92. Zucknick,SRichardsonandE.A.Stronach.ComparingtheCharacteristics

ofGeneExpressionProfilesDerivedbyUnivariateandMultivariateClassificationMethods,StatisticalApplicationsinGeneticsandMolecularBiology,7(1),Article7(2008)

91. CJackson,NBestandSRichardson.Hierarchicalrelatedregressionfor

combiningaggregateandindividualdatainstudiesofsocio‐economicdiseaseriskfactors.JournaloftheRoyalStatisticalSociety,SeriesA:StatisticsInSociety,171(1):1‐20(2008)

90. ALewin,NBochkinaandSRichardson.FullyBayesianMixtureModelfor

DifferentialGeneExpression:SimulationsandModelChecks,StatisticalApplicationsinGeneticsandMolecularBiology,6(1),Article36.(2007)

89. LJarup,SMorris,SRichardson,DBriggs,NCobley,CdeHoogh,KGorog,P

Elliott.Downsyndromeinbirthsnearlandfillsites.PrenatalDiagnosis,27:1191‐1196(2007)

88. JJAbellan,DFecht,NBest,SRichardson,DJBriggs.Bayesiananalysisof

themultivariategeographicaldistributionofthesocio‐economicenvironmentinEnglandEnvironmetrics,18(7):745‐758(2007)

87 ORatmann,,OJorgensen,THinkley,MPHStumpf,SRichardson,CWiuf.

UsingLikelihood‐FreeInferencetoCompareEvolutionaryDynamicsoftheProteinNetworksofH.pyloriandP.falciparuMPLoSComputationalBiology,3(11):e230(2007)

86. ETurro,NBochkina,AMKHeinandSRichardson.BGX:aBioconductor

packagefortheBayesianintegratedanalysisofAffymetrixGeneChipsBMCBioinformatics,8:439(2007)

85. SJBarton,SRichardson,DNPerkins,IBellahn,TNBryant,JCWhittaker.

UsingStatisticalModelstoIdentifyFactorsthathaveaRoleinDefiningtheAbundanceofIonsProducedbyTandemMS.AnalyticalChemistry,79(15):5601‐5607(2007)

84. MBlangiardoandSRichardson.Statisticaltoolsforsynthesizinglistsof

differentiallyexpressedfeaturesinrelatedexperiments.GenomeBiology,8:R54.(2007)

83. NBochkinaandSRichardson.Tailposteriorprobabilityforinferenceinpairwiseandmulticlassgeneexpressiondata.Biometrics,63(4):1117–1125.(2007)

82. POSchischmanoff,JMNaccache,A.Carrere,SRichardson,M

Kambouchner,MRaphae,D.Valeyre,R.Fagard.ProgressivepulmonarySarcoidosisisassociatedwithover‐expressionofTYK2andp21Waf1/Cip1.SarcoidosisVasculitisandDiffuseLungDiseases,23(2):101‐7(2006)

81. SRichardson,JJ.AbellanandNBest.Bayesianspatio‐temporalanalysisof

jointpatternsofmaleandfemalelungcancerrisksinYorkshire(UK).StatisticalMethodsinMedicalResearch,15:385‐407(2006)

80. CJackson,NBestandSRichardson.Improvingecologicalinferenceusing

individual‐leveldata.StatisticsinMedicine,25:2136‐2159(2006)79. SParry,DHadaschik,CBlancher,MKKumaran,NBochkina,HRMorris,S

Richardson,TJAitman,DGauguier,KSiddleetal.Glycomicsinvestigationintoinsulinaction.BiochimBiophyActa,1760:652‐668(2006)

78. AMHeinandSRichardson.Apowerfulmethodfordetectingdifferentially

expressedgenesfromGenChiparraysthatdoesnotrequirereplicates.BMCBioinformatics,7:353(2006)

77. PBroëtandSRichardson.DetectionofgenecopynumberchangesinCGH

microarraysusingaspatiallycorrelatedmixturemodel.Bioinformatics,22:911‐918.(2006)

76. ALewin,SRichardson,CMarshall,A.GlazierandTAitman.Bayesian

modellingofdifferentialgeneexpression,Biometrics,62:1‐9.(2006)75. AMHein,SRichardson,HCauston,GAmblerandPJGreen.BGX:afully

BayesiangeneexpressionindexforAffymetrixGeneChipdata.Biostatistics,6(3):349‐373(2005)

74. NBest,SRichardsonandAThompson.AcomparisonofBayesianspatial

modelsfordiseasemapping,StatisticalMethodsinMedicalResearch,14:35‐59(2005)

73. J.Bennett,MPLittle,SRichardson.Flexibledose‐responsemodelsfor

Japaneseatomicbombsurvivordata:Bayesianestimationandpredictionofcancerrisk.RadiatEnvironBiophys,43(4):233‐45(2004)

72. ALHansell,KALam,SRichardson,GVisickGandJBSorianoMedicalevent

profilingofCOPDpatients.PharmacoepidemiologyandDrugsafety,13(8):547‐55(2004)

71. PBroët,ALewin,SRichardson,andCDalmasso.Amixturemodel‐basedstrategyforselectingsetsofgenesinmulticlassresponsemicroarrayexperiments.Bioinformatics,20(16):2562‐71(2004)

70. SSeamanandSRichardson.Equivalenceofprospectiveand

retrospectivemodelsintheBayesiananalysisofcase‐controlstudies.Biometrika,91:15‐25(2004)

69. NCressie,SRichardsonandIJaussent.Ecologicalbias:useofmaximum‐

entropyapproximations.AustralianandNewZealandJournalofStatistics,46:233‐255(2004)

68. SRichardson,AThomson,NBestandPElliott.Interpretingposterior

relativeriskestimatesindiseasemappingstudies.EnvironmentalHealthPerspectives,112:1016‐25(2004)

67. LKnorr‐HeldLandSRichardson.Ahierarchicalmodelforspace‐time

surveillancedataonmeningococcaldiseaseincidence.JournaloftheRoyalStatisticalSociety,SeriesC(AppliedStatistics),52:169‐183(2003)

66. SRichardsonandNBest.Bayesianhierarchicalmodelsinecological

studiesofhealth‐environmenteffects.Environmetrics,14:129‐147(2003)65 PJGreenandSRichardson.HiddenMarkovmodelsanddisease

mapping.JournaloftheAmericanStatisticalAssociation,97:1055‐1070(2002)

64. SRichardson,VViallefont,PJGreen.BayesiananalysisofPoisson

mixtures,JNonparametricStats,14:181‐202.(2002)63. PBroët,SRichardsonandFRadvanyi.Bayesianhierarchicalmodelfor

identifyingchangesingeneexpressionfrommicroarrayexperiments.JournalofComputationalBiology,9:671‐683(2002)

62. SRichardson,LLeblond,IJaussentandPJGreen.Mixturemodelsin

measurementerrorproblems,withreferencetoepidemiologicalstudies.JournaloftheRoyalStatisticalSociety,SeriesA,165:549‐566(2002)

61. LJarup,DBriggs,CdeHoogh,SMorris,CHurt,ALewin,IMaitland,S

Richardson,JWakefield,PElliott.CancerrisksinpopulationslivingnearlandfillsitesinGreatBritain.BritishJournalofCancer,86(11):1732‐6(2002)

60. SRSeaman,SRichardson,IStückerandSBenhamou.ABayesian

partitionmodelforcase‐controlstudiesonhighlypolymorphiccandidategenes.GeneticEpidemiology,22:356‐368.(2002)

59. PElliott,DBriggs,SMorris,CdeHoogh,CHurt,TKJensen,IMaitland,S

Richardson,WakefieldJ,JarupL.Riskofadversebirthoutcomesin

populationslivingnearlandfillsites.BritishMedicalJournal,323:(7309),363‐8(2001)

58. SRSeamanandSRichardson.Bayesiananalysisofcase‐controlstudies

withcategoricalcovariates.Biometrika,88:1073‐1088(2001).57. VViallefont,AERafteryandSRichardson.Variableselectionand

Bayesianmodelaveragingincase‐controlstudies.StatisticsinMedicine,20:3215‐3230(2001)

56. PJGreen,SRichardson.Modellingheterogeneitywithandwithoutthe

Dirichletprocess.ScandinavianJournalofStatistics,28:355‐375(2001).55. MPLittle,IDeltour,SRichardson.Projectionofcancerrisksfromthe

JapaneseatomicbombsurvivorstotheEnglandandWalespopulationtakinginotaccountuncertaintyinriskparameters.RadiatEnvironBiophys,39:241‐252(2000)

54. SRichardson.Problèmesméthodologiquesdanslesétudesécologiques

santé‐environnement.LesComptes‐Rendusdel’AcadémiedesSciences(CRAS)Paris,SciencesdelaVie,323:1‐6(2000).

53. SCordier,CMonfort,LMiossec,SRichardson,CBelin.Ecologicalanalysis

ofdigestivecancermortalityrelatedtocontaminationbydiarrheticshellfishpoisoningtoxinsalongthecoastsofFrance,EnvironmentalResearch,SectionA,84:145‐150(2000)

52. CPascutto,JWakefield,NBest,LBernardinelli,PElliott,SRichardson,A

Staines.Statisticalissuesintheanalysisofdiseasemappingdata.StatisticsinMedicine,19:2493‐2515(2000)

51. VLasserre,CGuihenneuc‐Jouyaux,SRichardson.Biasesinecological

studies:utilityofincludingwithin‐areadistributionofconfounders.StatisticsinMedicine,19:45‐59(2000)

50. CGuihenneuc‐Jouyaux,SRichardson,IMLongini.Modellingmarkersof

diseaseprogressionbyahiddenMarkovprocess:applicationtocharacterisingCD4cellsdecline.Biometrics,56:733‐74(2000)

49. IDeltour,SRichardson,JYLeHesran.StochasticalgorithmsforMarkov

modelsestimationwithintermittentmissingdata.Biometrics,55:565‐573(1999)

48. CChouquet,SRichardson,MBurgard,S.Blanche,MJMayaux,CRouzioux,

DCostagliola.TimingofHumanImmunodeficiencyVirusType1(HIV‐1)transmissionfrommothertochild,Bayesianestimationusingamixture.StatisticsinMedicine,18:815‐833(1999)

47. LWatier,SRichardson,DHémon.Accountingforpregnancydependenceinepidemiologicalstudiesofreproductiveoutcomes.Epidemiology8:629‐636(1997).

46. Ruffié,NDelasnerie‐Lauprêtre,JPBrandel,IJaussent,DDormont,JL

Laplanche,JJHauw,SRichardson,AAlpérovitch.IncidencedelamaladiedeCreutzfeldt‐JakobenFrance,1992‐1995.Rev.EpidéMetSantéPubl.,45:448‐453(1997)

45. Garcia,JMaccario,SRichardson.Modellingoftheannualriskof

tuberculosisinfection.InternationalJournalofEpidemiology,26(1):190‐203(1997)

44. DLévy‐Bruhl,JMaccario,SRichardson,N.Guérin.Modélisationdela

rougeoleenFranceetconséquencespourl'âged'administrationdelasecondevaccinationrougeole‐oreillons‐rubéole.BulletinEpidémiologiqueHebdomadaire,29:133‐136.(1997)

43. DThomas,SRichardson,JGaudermanandJPitkaniemi.ABayesian

approachtomultipointmappinginnuclearfamilies.GeneticEpidemiology,14:903‐908(1997)

42. SRichardson,LLeblond.Somecommentsonmisspecificationofpriorsin

Bayesianmodellingofmeasurementerrorproblems.StatisticsinMedicine,16:203‐213(1997)

41. SRichardson,PJGreen.OnBayesiananalysisofmixtureswithan

unknownnumberofcomponents(withdiscussion).JournaloftheRoyalStatisticalSociety,SeriesB,59:731‐792(1997)

40. SRichardson.Développementsrécentsdelabiostatistique.Revue

d'EpidémiologieetdeSantéPublique,44:482‐493(1996)39. SRichardson,CMonfort,MGreen,GDraper,CMuirhead.Spatialvariation

ofnaturalradiationandchildhoodleukaemiaincidenceintheUnited‐KingdoMStatisticsinMedicine,14:2487‐2501(1995)

38. LWatier,SRichardson.Modellingofanepidemiologicaltimeseriesbya

thresholdautoregressivemodel(SETAR).TheStatistician,44(3):353‐364(1995)

37. Richard,SRichardson,J.Maccario.A3‐stateMarkovmodelfor

plasmodiumfalciparumparasitaemia.MathematicalBiosciences,117:283‐300(1993)

36. MFerraroni,MGerber,A.Decarli,SRichardson,etal.HDL‐cholesterol

andbreastcancer.InternationalJournalofEpidemiology,22:772‐780(1993)

35. JFViel,SRichardson,PDanel,PBoutard,PMalet,PBarrelier,O.Reman,A.Carre.ChildhoodleukemiaincidencenearLaHaguenuclearwastereprocessingfacility.CancerCausesandControl,4:341‐343(1993)

34. LWatier,SRichardson,B.Hubert.SalmonellaenteritidisinFranceandin

theU.S.:characteristisationbyadeterministicmodel.AmericanJournalofPublicHealth83:1694‐1700(1993)

33. JFViel,SRichardson.LymphomaandleukemiaamongFrenchfarmersin

relationtopesticideexposure,SocialSciencesandMedicine37(6):771‐777(1993)

32. SRichardson,W.R.Gilks.Aconditionalindependenceapproachto

covariatemeasurementerror,StatisticsinMedicine,12:1703‐1722(1993)31. SRichardson,W.R.Gilks.ABayesianapproachtomeasurementerror

problemsinepidemiologyusingconditionalindependencemodels.AmericanJournalofEpidemiology,138:430‐442(1993)

30. PDiggle,SRichardson.Epidemiologicalstudiesofindustrialpollutants:

anintroduction.InternationalStatisticalReview,61:203‐206(1993)29. Hubert,LWatier,PGarnerin,SRichardson.Meningococcaldiseaseand

influenza‐likesyndrome:anewapproachtoanoldquestion.TheJournalofInfectiousDiseases,166:542‐545(1992)

28. SRichardson,R.Zittoun,S.Bastuji‐Garin,V.Lasserre,C.Guihenneuc,M

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27. SRichardson.Modélisationstatistiquedesvariationsgéographiquesen

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26. WRGilks,SRichardson.Analysisofdiseaserisksusingancillaryrisk

factorswithapplicationtojob‐exposurematrices.StatisticsinMedicine,11:1443‐1463(1992)

25. Mollié,SRichardson.EmpiricalBayesestimatesofcancermortalityrates

usingspatialmodels.StatisticsinMedicine,10:95‐112(1991)24. LWatier,SRichardson,B.Hubert.Atimeseriesconstructionofanalert

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23. C.Ségala,MGerber,SRichardson.Thepatternofriskfactorsforbreast

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22. FCavallo,MGerber,SRichardson,etal.ZincandCopperinbreastcancer.

AjointstudyinNorthernItalyandSouthernFrance.Cancer67(3,):738‐745(1991)

21. MGerber,SRichardson,RSalkeld,PChappuis.Anti‐oxidantsinbreast

cancerfemalepatients.CancerInvestigation9(4):421‐428(1991)20. SRichardson,MGerber,S.Cénée.Theroleoffat,animalproteinandsome

vitaminconsumptioninbreastcancer:acase‐controlstudyinSouthernFrance.InternationalJournalofCancer48:1‐9(1991)

19. JFViel,SRichardson.Adultleukemiaandfarmpractices:analternative

approachforassessinggeographicalpesticideexposure.SocialScienceandMedicine32:(9),1067‐1073(1991)

18. SRichardson,CGuihenneuc,VLasserre.Spatiallinearmodelswith

autocorrelatederrorstructure.TheStatistician41:539‐557(1991)17. SBastuji‐Garin,SRichardson,RZittoun.Acuteleukaemiainworkers

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16. JFViel,SRichardson.ChildhoodleukemiaaroundtheFrenchnuclear

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13. PClifford,STRichardson,D.Hémon.Assessingthesignificanceofthe

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12. MGerber,SRichardson,PCrastesdePaulet,HPujol,ACrastesdePaulet.

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11. STRichardson,IDeVincenzi,MGerber,HPujol.Alcoholconsumptionin

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10 FDerriennic,STRichardson,AMollié,JLellouch.ShorttermeffectsofSO2pollutionofmortalityintwoFrenchcities.InternationalJournalofEpidemiology18:186‐197(1989)

9. MGerber,FCavallo,EMarubini,STRichardson,ABarbieri,ECapitelli,A

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8. STRichardson,AHirsch,PRuffié,MBickel.Relationshipbetween

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7. STRichardson,IStücker,DHémon.Comparisonofrelativerisks

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6. IStücker,STRichardson,DHémon.Contraceptifsorauxetmortalité

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2. STRichardson.Stoppingtimesformeasure‐preservingtransformations:

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1. STRichardson,KMWilkinson.Stoppingtimetransformationsand

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