Curriculum Vitae

Curriculum Vitae

Dr. Yusuf Mohammad Ali Al-Hiari

Professor of Medicinal Chemistry

Department of Pharmaceutical Sciences

Faculty of Pharmacy

Jordan University

Amman 11942 Jordan

00Tel: 00962-6- 5355000. ext. 23292 (Work), Mobile : 00962777424744

Fax: 00962-6-5300250 Faculty, 00962-6- 5355511-22 University

Email: al_hiariyusuf@hotmail.com, hiary@ju.edu.jo

Home Page:  http://eacademic.ju.edu.jo/hiary/Lists/Published%20Research/AllItems.aspx

Personal Information

Marital status: Married, 4 children

Nationality: Jordanian

Age: 46

2001- present Faculty of Pharmacy – Jordan University.

Amman, Jordan.

Professor - Department of Pharmaceutical Sciences.

Specialized in teaching Pharmaceutical Chemistry, including Organic, Medicinal, Analytical, Instrumental and Biotechnology Based drug Discovery.

- Dean Assistant for Students Affairs / 2003-2005.

- Head Dept. Pharmaceutical Sciences / 2005-2006; 2008/2009.

- Vice Dean / 2006 - 2007

1998 – 2001 Department of Pharmaceutical Chemistry–Strathclyde University.

Glasgow, Scotland-UK

Ph.D. in Pharmaceutical Sciences: Medicinal Chemistry.

Title: Steps Toward an Efficient Synthesis of Macrocyclic Bisbenzylisoquinoline Alkaloid.

1996 – 1997 School of Biological Sciences - Surrey University.

Surrey, Guilford, UK

M.Sc. in Clinical Biochemistry and Molecular Biology.

1989 – 1993 Faculty of Pharmacy - University of Jordan.

Amman, Jordan

B.Sc. in Pharmaceutical Sciences. Very Good.

1988-1989 Salt Secondary School.

Salt, Jordan

General Secondary Education Certificate Examination. Distinction.

Work Experience

2001- present Faculty of Pharmacy – Jordan University.

1998 –1999 Pharmacy Department – Strathclyde University

Glasgow, Scotland

Lab. Demonstrator (teaching and research assistant) for MSc and undergraduate pharmacy students.

1993- 1996Pharmaceutical Chemistry Dept- Faculty of Pharmacy -University of Jordan.

Amman, Jordan

Teaching Assistant for practical courses: Medicinal, Organic, Instrumental, Analytical and

Clinical Chemistry.

1994 Community Pharmacy.

Amman, Jordan

1994-1996 Faculty of Education-University of Jordan

9 courses in teaching methodologies and evaluation techniques for undergraduate and

postgraduate students.

Skills

- Arabic and English (Both excellent)

- Computer Literacy: Word , Excel , Power Point, Chemdraw, Isis draw, Alchemy 2000, ChemDraw Ultra.

- Chemistry Databases: Beilestine Crossfire System, ISIS, BIDS, MEDLINE, Scifinder, Web of

Science WOS, SCI, Embase data base, Elsevier, PUP-mide, Cambridge Database,…etc.

· Operational and theoretical skills in NMR, MS, and IR Spectroscopy.

· Very good experience in HPLC, GC-MS, LC-MS, CE, and most gravimetric separation techniques.

· Very good knowledge and satisfactory practical experience in many Molecular Biology techniques such as DNA Isolation and Gene Detection, Clonning, Finger-printing, Southern and Northern Plott, RELF, PCR and all Clinical Biochemistry ones in addition to Immunology Techniques such as Enzyme Linked Immunoassay (ELISA), Monoclonal Anti-bodies and Radio Immuno Assay (RIA).

· Specialized skills in synthetic chemistry, organic reactions and many bioassay procedures.

· Satisfactory experience in Tissue and Cell culture techniques, mainly animal cell culture.

Teaching Experience at the University of Jordan:

1-Undergraduate Courses, Faculty of Pharmacy:

a- Obligatory courses

- Medicinal Chemistry III, Fifth year students

- Medicinal Chemistry II, Fourth year students

- Medicinal Chemistry I: drug design, Fourth year students

- Medicinal Chemistry III and II / practical, Fourth and Fifth year students

- Pharmaceutical Analytical Chemistry, second year students

- Pharmaceutical Organic Chemistry I, Second year students

- Pharmaceutical Organic Chemistry I / practical, Second year students

- Pharmaceutical Organic Chemistry II, Second year students

- Clinical Biochemistry, Forth year students

- Instrumental Analysis, Third year students

b- Elective courses

- Chelation: Principles and Applications in Pharmacy, Fifth year students

- Pharmaceutical Biotechnology, Fifth year students

- Chromatography, Fifth year students

2-Master students:

- Advanced Medicinal Chemistry, Master students

- Advanced Pharmaceutical Biotechnology, MSc students

3-PhD courses (medicinal chemistry and drug discovery)

- Advanced Research Methodologies in Medicinal Chemistry, Ph.D course

- Information Technology, Ph.D course

- Selected topics in medicinal chemistry, Ph.D course

- Advanced Spectroscopy, Ph.D course

Administrative Activities:

1- Member of the Postgraduate committee at Deanship of Postgraduates (2012/2013,2014)

2- Member of the University Council (2012-2013)

3- Head of Department of Pharmaceutical Sciences (2008-2010 ).

4- Sabbatical leave (Al-Zaytooneh University, 2007-2008)

5- Vice Dean / 2006 – 2007

6- Head of the Postgraduate committee at Deanship of Postgraduates (2006/2007)

7- Head of Department of Pharmaceutical Sciences (2005-2006 ).

8- Dean Assistant for Students Affairs, Faculty of Pharmacy (2003-2005).

9- Member of the Postgraduate committee at faculty (2006/2007, 2008-2010)

10- Member of the Postgraduate committee at Deanship of Postgraduates (2006/2007)

11- Member of the Department Council (2001-2013)

12- Member of the Faculty Council (2003, 2005-2010, 2012, 2013)

13- Head of the Department Council (2005-2006, 2008-2010)

14- Member of the University Council (2002-2003)

15- Sabbatical leave (Al-Zaytooneh University, 2014-2015)

16- Head of the Instrumentation and laboratories committee at faculty (2015/2016)

17- Head of the scientific committee at faculty (2016/2017)

18- Member of Scientific and Research Council of the Deanship of Academic Research faculty Al-Zaytooneh University (2016/2017)

19- Member of the Department Council (2015-2017)

Committees / Health sector:

Regular member in consultation and committees of the Jordan Food and Drug Administration and Ministry of Health.

- Member of the Clinical Studies Committee at Jordan Food and Drug Administration (JFDA), 2004-2006.

- Member of the Jordanian Pharmaceutical Society, (1993-up today).

- Member of the Drugs Re-registration Committee at Jordan Food and Drug Administration (JFDA), 2008-2010; 2012-2014.

Committees / Accreditation sector:

Regular member in consultation, examination, accreditation and quality assurance committees of the Jordan Accreditation Council for Higher Education.

- Head of the accreditation committee of Pharmacy colleague at Al-Hashmeia University, 2013.

- Head of the accreditation committee of Pharmacy colleague at Amman private University, 2015.

- Member of the accreditation committee of Pharmacy colleague at Al-Zaytooneh private University, 2015.

- Member of the accreditation committee/Quality assurance - Pharmacy colleague at Al-Petra Jordan University, 2015-2016.

- Head of the accreditation committee of Pharmacy colleague at Al-Hashmeia University, 2013.

- Head of the accreditation committee of Pharmacy colleague at Amman private University, 2015.

- Member of the accreditation committee of Pharmacy colleague at Al-Zaytooneh private University, 2015.

- Member of the accreditation committee/Quality assurance - Pharmacy colleague at Al-Petra Jordan University, 2015-2016.

Committees and Societies:Faculty, University and National ; Academic

- Member of the Postgraduate Studies Committee at the Faculty of Pharmacy, (2005-2010).

- Member of the Scientific Research Committee at the Faculty of Pharmacy-University of Jordan, (2001-2007, 2014-00).

- Member of the Research and Instrumentation Committee at the Faculty of Pharmacy-University of Jordan, (2001- 2003).

- Director (Head) of the General Safety Committee at the Faculty of Pharmacy-University of Jordan, (2001-2004, 2010-2016).

- Member of the Instrumentation and Laboratory Safety committee at the Faculty of Pharmacy-University of Jordan, (2003-2005, 2011-12).

- Member of the Courses Evaluation Committee, (2005-2010, 2015).

- Member of the Curriculum Committee at the Faculty, (2005-2010)

- Member of the Student’s Affair Committee at the Faculty of Pharmacy, (2003-2005).

- Member of the Royal Society of Chemistry (United Kingdom)- Student membership, (1999-2001).

- Friend of the Society of Chemistry- Scotland, (1998-1999).

- Member of the Scientific and Research Committee at the Pharmaceutical Association of Jordan, (2001-2005, 2008-2010).

- Involved in many committees related to Central Tender Department: Head and member for more than 20 committees.

- Member and examiner at the Boarding Committee of the Jordanian Pharmaceutical Society, 2003-2004, 2008-2009 (Pharmacy Profession Qualification Exam).

- Member of the Pharmacy Qualification Exam Committee/ Ministry of Higher Education, 2005-2006, 2013-2014 (Pharmacy Gradates Qualification Exam).

- Member of the Higher organizing/ Pharmacy Qualification Exam Committee/ Ministry of Higher Education, 2006-2007 (Pharmacy Gradates Qualification Exam/ first semester).

- Head of the Postgraduate committee at the faculty of Pharmacy 2006-2007, 2009-2010.

- Member of the Postgraduate committee at the Deanship of Postgraduate Studies (2006/2007, 2008-2010)

- Member of the National center of Biotechnology/ Jordan, 2004-2010

- Member at the editorial board of the international Journal-2006-2007: Pharmacy times-Middle East, established since 1897, published by Medical online Publication SAL, Beirut, Lebanon, Under licenses from Ascend Media Healthcare.

- Referee for Archiv Der Pharmazie: International Journal of Medicinal Chemistry, since 2006.

- Referee for Jordan Journal of Pharmaceutical Sciences: International Journal Pharmaceutical Sciences, since establishment 2007-uptoday.

- Reviewer for King Abdul Aziz University, Deanship of Academic Research, Saudia Arabia, 2005- …).

- Reviewer for King Saud University, Deanship of Academic Research, Saudia Arabia, 2009- …).

- Member of the faculty council, 2005-2007, 2008-2010.

- Referee for Medicinal Chemistry research Journal , since 2009.

- Member (Hony. Editor) of the Editorial Board of Journal of Plant Development Sciences -2011

- Member of the Editorial Board for the Journal of Pharmaceutical Technology and Drug Research (JPTDR), 12-2011, . http://www.hoajonline.com/Journal-of-Pharmaceutical-Technology-and-Drug.html#tabs2-2

- Referee for Medicinal Chemistry research Journal , 2013.

- Referee for Medicinal Chemistry Journal , 2013.

Scientific Activities: Conferences, Meeting and Workshops:

- Chairman of the Social Committee of the 2nd International Conference of the Faculty of Pharmacy, October 16-18/2001, Amman-Jordan (Member of the Organizing committee, member in the Scientific Committee, member in the Follow-Up Committee, Conference book organizer and editor).

- Chairman of the Social Committee of the 5th Scientific Congress of the Association of the Colleges of Pharmacy in the Arab World , October 16-18/2001, Amman-Jordan (Member of the Organizing committee, member in the Scientific Committee, member in the Follow-Up Committee, Conference book organizer and editor)

- Member of the Scientific Committee which organized the 10th Pharmaceutical Jordanian Conference of the Jordanian Pharmaceutical Society, March 13-16/2002, Amman-Jordan (Conference book editor).

- A primary lecturer at the Jordan Ninth Science Week: Biotechnology and its Role in the Jordanian Economy, entitled: Pharmaceutical Biotechnology: “Recombinant DNA Technology as a Tool for the Production of Biopharmaceutical Drugs”, 6-8 October 2003, University of Science and Technology/ Irbid-Jordan.

- Contributor in the first round of the Continuous Education Programme supervised by the Jordanian Pharmaceutical Society, 2001, Amman.

- Organizer and contributor of the second round of the Continuous Education Programme supervised by the Jordanian Pharmaceutical Society, 2002, Amman.

- Member of the Organizing Committee/ Scientific Committee which organized the 11th Pharmaceutical Jordanian Conference of the Jordanian Pharmaceutical Society, March 28-30 Sep/2005, Amman-Jordan.

- A guest speaker at the 11th Pharmaceutical Jordanian Conference of the Jordanian Pharmaceutical Society, title: Original research paper/primary lecture: Crignard Synthesis of 1-Substituted Benzyl-1,2,3,4-tetrahydroisoquinoline Models with Potential Antibacterial and Anticancer Activity, Sept. 28-30/2005, Amman-Jordan.

- Attendant and contributor in the “The First Conference for Scientific Research in Jordan”. Organized by the Society of Friends of the Scientific Research in Jordan Universities, 25-26th/10/2003, Amman-Jordan.

- ICH/GCP Training Workshop for Clinical Investigators, 2-3/12/2004, Dubi, UAE.

- Contributor and attendant of the Synthesis of Chemicals and Pharmaceutical Raw Materials Conference, Title: Synthesis of Pharmaceutical Raw Materials in Jordan. Organized by the Arab School for Science and Technology, 23-25/5/2005, Damascus-Syria.

- Workshop by Varian Company-US, entitled: ‘Separation techniques: HPLC, GC-MS, LC-MS’ Organized by their agent in Amman; Amin Shukeer drug stores, 4-7-2004, Amman.

- Workshop by Bruker Company, entitled: ‘X-Ray and FT-NIR techniques’: Principles and Applications, Organized by their agent in Amman; Sena Establishment for Laboratory Equipment Trading, 31-8 to 1-9 / 2005, Amman.

- Abstract accepted at the 9th International Pharmaceutical Sciences Conference and Exposition and the 9th General Assembly Meeting of the Scientific Society of Colleges of Pharmacy of the Association of Arab Universities in the Arab World, Original research paper/primary lecture: Synthesis of Substituted benzyl-N-acyl-1,2,3,4-Tetrahydroisoquinoline Derivatives and Investigation the Lithiation-Alkylation Chemistry, 17-21/1/-2005, Riyadh- Saudi Arabia.

- Primary lecturer and full paper presenter at “The Importance of Intellectual Property in Scientific Research and Economic and Industrial Growth in the Arab World” Conference; 23-25/1/2006, Damascus-Syria. Title: Patent Challenges in Pharmaceutical Sector; Impact, Overcoming Challenges and Future Prospective, by Dr. Yusuf Al-Hiari and Dr. Talal Aburjai.

- Workshop entitled: A Non Threatening Approach to the Use of Statistics in Clinical Trials, 5/4/2006, Prof. James De Muth, Royal Medical Services, Amman.

- The Third Medical Conference for Royal Medical Services, April 2006, Amman.

- The First Scientific Week for the Faculty of Pharmacy at Amman University, 3-4/5/2006.

- Primary lecturer and round mediator at the Jordan International Pharmaceutical Conference 2006: Toward new Trends in Pharmaceutical Sciences, Al-Zaytoonah University, 5-17-11-06, Amman-Jordan.

- Primary lecturer and round mediator at the First Scientific Conference 2006 for OTC drugs: Jordan Pharmaceutical Association, 1-4-12-2006, Amman-Jordan.

- Workshop on new instruments provided by Thermo Company: GC, GC/MS, LC, LC/MS, Molecular Spectroscopy (UV, FT-IR, NMR) 22-23 May 2007, Amman-Jordan.

- Training course: Literature survey on data bases: SCI-finder and EBSCO, 12-13/6/2007, University of Jordan-Amman-Jordan.

- Primary lecturer for a full paper “ Synthesis and Antibacterial Properties of New 8-Nitro fluoroquinolone Derivatives'', at the 5th International Symposium on Pharmaceutical Chemistry, abstract and oral presentation, Sep. 5-7, 2007, Istanbul, Turkey.

- Mid East Medical International Comprehensive Exhibition 2008, Amman, Oct. 21-23/ 2008, Amman- Jordan.

- Member of the Scientific Committee which organized the 13th Pharmaceutical Jordanian Conference of the Jordanian Pharmaceutical Society, April 2010, Amman-Jordan (Conference book editor).

- Member of the Scientific Committee which organized the Faculty Scientific day-Faculty of Pharmacy, 6th May 2010, Amman-Jordan.

- Guest speaker, National Medical Research Center, Al-Zawia- Libya, 13May, 2010.

- National Conference for the Development of Study plans, Teaching and Learning, and Scientific Research in Jordan, June Amman 15-17, 2010, organized by Ministry of Higher Education and Scientific Research.

- Lecture and oral presentation: "Synthesis and Antibacterial Activity of New [1,2,3] triazolo[4,5-h]quinoline Derivatives as Potential Antimicrobial Agents" at First United Arab Emirates Conference on Pure and Applied Chemistry (ECPAC11), American University of Sharjah, Sharjah, UAE, 1-3/3/2011.

- Oral presentation: "Synthesis and Antibacterial Activity of New [1,2,3] triazolo[4,5-h]quinoline Derivatives as Potential Antimicrobial /Anti-tuberculosis Agents" The International Conference on Materials in Jordan, Humboldt Kolleg, German –Jordanian University (GJU), Amman, Jordan, 9-11 April /4/2011.

- Work shop: Commercialization of R & D results : Patents and trade secrets, Intellectual Property Commercialization Office IPCO , Royal Scientific Society- Amman , 18-19 April 2011.

- Oral presentation: " Pyrido-Quinoxalinones, As potentiel antibacterial and anticancer compounds" The 4th International Conference on Health Care (ICHC), Al-Ahliyya Amman University,, Amman, Jordan, 4-5 May /5/2011.

- The Faculty Scientific day-Faculty of Pharmacy, 28th April 2011, Amman-Jordan.

- Contribution in the Scientific day for Hamdi Mango Center for Scientific Research (HMCSR), 24th May 2011, Amman-Jordan.

Workshop: Use of FT-IR spectroscopy in and out the laboratory, Organized by GSC company for Agilent Company, 2-11-2011, Amman-Jordan.

-Reviewer database for " Current Computer-Aided Drug Design journal " http://bsp-cms. eurekaselect.com/index.php/ CCADD. Bentham Science Publisher, May 2012-2013.

- Primary lecturer and round mediator : New antibacterial fluoroquinolones with potential anti-obesity effects

at the Jordan International Pharmaceutical Conference 2015: Al-Zaytoonah private University, 21-23 October 2015, Amman-Jordan.

· Workshop: Winter workshop 2015 on heavy metal and water treatment within collaboration project between German Jordainian University and Leibniz institute for Analytical Sciences-ISAS, German University, Madaba, 18-22/10/2015.

- Workshop: Building successful partnerships between Academia and Industry-The Pharmaceutical Sector, the Jordanian Club of Humboldt Fellows and Friedrich Naumann Foundation for Liberty, Amman 13/4/2016

- Lecture and oral presentation: " Novel 5-substituted indole-2-carboxamide derivatives as potential antihyperlipidaemic Agents" at Second United Arab Emirates Conference on Pure and Applied Chemistry (ECPAC16), American University of Sharjah, , UAE, 1-3/3/2016.

- Attendance: The 1st International conference on Natural Producs and Drug Discovery, Chemistry Dept, Ammn Sep 8-10, 2015.

Social Activities:

- Winner of the Bronze Medal of Prince Hasan Award for Culture and Youth Development, (1987 and 1988).

- Winner of the Students Jordanian Chess Championship, 1986 (second), 1987 (Third).

- Member at Salt Pioneer Center for Highly Intelligent Students, (1986-1989 student, 2002- full member).

- Member at Salt Heritage center .

- Certificate of Gratitude from The Jordan Pharmaceutical Association: for the major contribution in its activities;

in particular; the Continuous Education Program (2001, 2002).

- The Jordan Pharmaceutical Association Award, (2005, 2008, 2010).

Current Areas of Research Projects:

I- Medicinal Chemistry and Organic Synthesis:

(A) Synthesis of Novel Bisbenzylisoquinolines Models:

· This work aims at synthesis of new bisbenzylisoquinoline models with two ether linkages as potential antimalarial compounds. The model molecules were designed to exhibit the pharmacophoric groups occurred in natural bisbenzylisoquinoline, with broad spectrum of activity. The research has produced initially; three target molecules which could be potential antimalarial and possibly, anticancer agents. This research produced many intermediates with reasonable antibacterial activity, derived from benzyloxyphenyl-ethanol nucleus and 3,4,8,9-tetrahydro-13-oxa-6-thia-2,10-diazapentacene nucleus. Moreover, other intermediates showed weak to moderate antifungal properties.

- New research line was emerged to prepare novel models of bisbenzylisoquinoline with one ether linkage. For the first time, a novel metalation approach was developed to prepare such new models with yields exceeded 80%. Such new approach might revive the synthetic research toward preparation of naturally occurring derivatives of the same group. (Two papers are in preparation)

(B) Preparation of Model Benzyl isoquinoloines and Investigation the Chemistry of Coupling Reactions:

· Introducing benzyl substituents at position 1 of di and tetrahydroisoquinoline systems was thoroughly investigated using different methods reported in the literature. Grignard reactions and metalation chemistry were attempted. Although Grignard conditions were satisfactory, the new metalation conditions developed were successful in producing new model derivatives at position 1 in more than 90% yields. These prepared models exhibit possible potential as anticancer compounds. The new conditions and procedures are implemented now in preparing benzyl isoquinoloines and bisbenzylisoquinoline derivative of natural origin.

(C) Development of Novel Phenoxathiin-Based Antifungal Agents:

· This research aims at preparing phenoxathiin-based derivatives of superior antifungal potencies; through the introduction of well-established antifungal moieties to position 2 and 8 or 3 and 7 of the phenoxathiin nucleus allowing mutual potentiation of the overall antifungal properties. The proposed potentiating groups include: pyridine, pyrrole, 1,2,3-triazole, imidazole, 2-aminothiazole, thiazole and others, which have well established anitfungal properties. Furthermore, allylamine moieties is proposed to be also conjugated to phenoxathiin nucleus at later stages allowing the access to quite potent antifungal agents. Moreover, the proposed phenoxythiin-based derivatives could be chemically conjugated to various polymers that might generate interesting materials of possible commercial applications, including the development of fungus-resistant textiles or plastics. Because of the tedious procedures and low yields, this research started by developing and improving approaches needed to prepare the methyl substituted phenoxathiin system.

(D) Synthesis of New Potentially Anticancer Azepino-indoloquinoline Systems.

- This work involves addition of 1-Chloro-4-trifluoromethyl-2-nitrobenzene, 2-chloro-4-trifluoromethyl-1,3-dinitrobenzene, 4-chloro-3,5-dinitrobenzoic acid, 2-chloro-3-nitrothiophene and 5-chloro-1,3-dimethyl pyrazole appendages to indole system at position 3. This was followed by reductive cyclization procedure to produce either the azepino or the quinoline systems (or both). Although Bischler-Napieralski was not promising, the Pictet-Spengler cyclization showed good results. All the indolo phenyl derivatives substituted with amino, nitro and other groups were evaluated for their antimicrobial properties, revealing promising results.

(E) Preparation of Novel Heterocycles [h]Fused Onto 4-Oxoquinolines for Biological Evaluation:

This research involves preparation of 8-nitrofluoroquinolone system, followed by introducing new appendages at C-7 and finally formation of new heterocyclic [h]fused systems. The research has led to novel systems with diverse biological evaluation such as benzofuroxane, Pyrido[2,3-g]Quinoxalines, triazoles, diazepines and benzodiazepines fused at h position. More than 10 publications have been disclosed up today on this line.

(F) Preparation of Potentially Antibacterial 8-nitro/ or 8-amino Fluoroquinolones with Novel Substitutions at Position 7.

II- Novel Polymeric Modifications with Potential Pharmaceutical Applications:

· The first area involves chemical modifications of existing natural and synthetic biodegradable polymers, aiming at utilizing the newly-developed polymers in pharmaceutical applications, such as, in new drug delivery systems and sustained release matrices. The principle of this modification is based on synthesis of metal-chelating polymeric linkers followed by their cross-synthetic linking with metallic cations. The generated matrices have proved to be very useful matrices for prolonging drug release.

III- Novel Polycarbonates Polymer Synthesis with Potential Industrial Applications:

- The other research area involves preparation of novel polycarbonate polymers with new or modified procedures for industrial and possibly pharmaceutical applications.

IV- Analytical Methods Development Related to Drugs or Separation Techniques:

- Liquid chromatographic determination of Sartans (Irbesartan) in human plasma with fluorescence detection

- Blood Spot Analysis for Anti epileptic drugs using HPLC system with fluorescence detection

- Developing and optimization of HPLC, LC/MS methods for new synthetic systems, drugs and some natural pharmaceutical products.

V- The discovery of novel heterocyclic 2-carboxamide derivatives with potential dyslipidemic, hypoglycaemic and antioxidant activity

This research line was introduced to develop novel class of indole-2-carboxamides, benzofuran-2-carboxamides and benzothiophene-2-carboxamides with antihyperlipidemic activity. This novel class of derivatives have shown excellent activity against triglycerides mainly in a fibrate like manner; stimulation of lipoprotein lipase enzyme. More research is undergoing to investigate new heterocycles and further antioxidant and antihyperglycemic effect.

VI- Evaluation of new phenolic and benzoic acid derivatives as novel inhibitor of carbonic anhydrase isozyme III by using a modified Hummel-Dreyer method. (2012- up-to-date).

VIII. Fluoroquinolone as new inhibitors for pancreatic lipase enzyme. (2013- up-to-date)

Local / National / International projects:

1- Design and Synthesis of Novel Hepatitis C virus-NS3 Protease Inhibitors (Primary Author, 2002): This project was approved by the National Committee for the Higher Education Development Fund (HEDF) and Dar Al-Dawa Pharmaceutical Company. The fund was more than $350,000 from both and more than JD 260,000 from the university.

2- Establishing a New Ph.D. Program in Medicinal Chemistry and Drug Discovery at the Faculty of Pharmacy/University of Jordan, (Primary Author, 2003): Submitted to the National Committee for the Higher Education Development Fund (HEDF), September 2003. The project was subsidized with $ 350,000 by the National Committee for the Higher Education Development Fund HEDF and $323,000 by the University.

3- Development of Novel Phenoxathiin-Based Antifungal Agents, (Primary Author, 2002): This project was funded by the Dean of Scientific Research-University of Jordan, 10,000 JD.

4- Synthesis of New Potentially Anticancer Azepino-indoloquinoline Systems, (Primary Author, 2003): This project was funded by the Deanship of Scientific Research-University of Jordan, 7500JD.

5- New 7-(3-indolyl)quinolones, Indolo[2,3-c], [1,10]phenanthrolines and 3,3’-bisindolyl systems: Syntheses and Antibacterial Study Protocol, (Primary Author, 2004): The project was sponsored by Hamdi Mango Center for Scientific Research, Jordan University.

6- Pyrido[2,3-f]Quinoxalines and Pyrido[2,3-g]Quinoxalines, A Process for their Preparation and their Use as Antiviral and Antibacterial Agents and [a]Fused Heterocyclic-Pyrido[2,3-f]Quinoxalines-2-carboxylic acid Derivativesz and their Pyrido[3,2-g]analoges, A Process for their Preparation and their Use as Anticancer and Antibacterial Agents, (Primary Author, 2005): The project was sponsored by Hamdi Mango Center for Scientific Research, Jordan University.

7- Synthesis and Antitumor Potency of Some Novel pyrido[2,3-a]carbazoles, (Second Author, June 2006). The project was sponsored by The Higher Council for Science and Technology.

8- Investigation and Monitoring of Organophosphates Toxicity in Jordan Valley, (Second Author, 2005). The project was funded by OPCW-United Nation and The Deanship of Scientific Research-University of Jordan.

9- Blood Spot Analysis for Anti-epileptic drugs using HPLC system with fluorescence detection, July 2006-2008, funded by the Deanship of Scientific Research-University of Jordan.

10- Part 1: N4- (substituted) Pyrido[2,3-f]quinoxalines, A process for their preparation and their use as potential antiviral and antimicrobial agents, (Primary Author, 2007-9): The project was sponsored by Hamdi Mango Center for Scientific Research, Jordan University.

11- Preparation of new diazepino[2,3-h]quinoline-9-carboxylic acid derivatives and their analogus [b]fused benzodiazepine derivatives. Sabbatical leave project. 2007/2008, Al-Zaytooneh University.

20- Part II: N4- (substituted) Pyrido[2,3-f]quinoxalines, A process for their preparation and their use as potential antiviral and antimicrobial agents, (Primary Author, 2009): The project was sponsored by Hamdi Mango Center for Scientific Research, Jordan University.

21- Convenient Synthesis and Bioproperties of Heterocycles [h]-Fused Onto 4-Oxoquinoline-3-Carboxylic Acid: Substituted Hexahydro[1,4]diazepino[2,3-h]quinoline-9-carboxylic acid, (Primary Author, 2010): This project was funded by the Deanship of Scientific Research-University of Jordan, 15200JD.

22- Pharmacodynamic evaluation and marker standardisation of Paronychia argentea (Rijl El Hmameh) as a diuretic herb. (May 2010-2012): This project was funded by the Deanship of Scientific Research-University of Jordan-15000JD ( in collaboration with Savant).

23- Synthesis and biological screening of new Ethyl-9-cyclopropyl-4-fluoro-3-(4-substitutedphenyl)-6-oxo-6,9-dihydro-3H-[1,2,3]triazolo[4,5-h]quinoline-7-carboxylate derivatives and their carboxylic acid counterparts, (Primary Author, May 2012): This project was funded by the Deanship of Scientific Research-University of Jordan, 18.000JD.

24- Evaluation of new inhibitor of carbonic anhydrase isozyme III by using a modified Hummel-Dreyer method: approach for drug discovery, (second Author, Aug. 2013): This project was funded by the Deanship of Scientific Research-University of Jordan.

25- Antibacterial Fluoroquinolones as Novel Inhibitors of Pancreatic Triacylglycerol enzyme, a New

Target for The Management of Dyslipidaemia, Atherosclerosis and Obesity, , (sabbatical 2015), This

project is part of the sabbatical leave research for 2015 and was conducted and funded at

Al-Zaytooneh Private University. Testing and biological screening part was funded by the Deanship

of Scientific Research-University of Jordan.

26- Purification of Pathogenesis Determinant proteins for the identification of novel antimicrobial targets: Polyphosphate Kinase 1 active site charecterization, 2014-2016, this project was funded by Scientific Research

Support Fund-The Ministry of Higher Education for more than 90,000JD.

27- Biological Evaluation of in vitro inhibitory effects of some medicinal plants of the families Asteraceae, Lamiaceae and Papaveraceae native to Jordan and synthetic compounds on lipase, DPPVI and protein glycation. MPH/1/05/2014, SRF-Ministry of Higher Education, 34600JD, 2014.

28- Lipase inhibitory potential of synthetic fluoroquinolones and their modulatory effects of adipocytes differentiation and adipogenesis, DAR/JU [1630], 10000JD, 2013-2014.

29- Natural benzoic and cinnamic acid derivatives as anti-obesity agents: In vitro modulation of Pancreatic Lipase, DAR /JU[1745, 10000JD, 2015.

30- Structure-based discovery and crystallographic studies of benzoic acid derivatives as novel anti-obesity agents, SRF, 2015, Scientific Research- Support Fund, 150000JD, 2015.

31- Development and investigation of synthetic compounds for anticancer effects in vitro, DAR /JU[1745, 20000JD, 2016

32- Fabrication of fast oral drug delivery systems using hot melt extrusion technology to assist swallowing, taste masking and throwing light onto improved solubility applications, (co-author with German University,SRSF- 90000, 2016).

33- A promising hybrid anticancer drug based on a stimulated physicochemical conjugation of a novel anticancer with gold nanoparticle. (co-author with JUST and yarmook Universities, SRSF- 57000, 2017).

Projects in Collaboration with Local Industry:

1- Developing New Muscle Relaxant, Derived from the Known Commercial Muscle Relaxant Atra-curium, in collaboration with Hikma Pharmaceuticals, 2002.

2- Developing New Class of Antifungal Agents Derived from 2-Aminothiazole Nucleus, in collaboration with The international Company for Pharmaceutical Research, 2003.

3- Developing Bulk Scale Synthetic Approaches to Prepare Ciprofloxacin, in collaboration with Hikma Chemicals, 2004.

4- Developing Bulk Scale Synthetic Approaches to Prepare Ceftiufor, in collaboration with Al-Najma Bulk Pharmaceuticals, 2005.

5- Establishing a method of analysis and standardization study of oral drops formula from (Paronychia argentea extract), for kidney stones management, Al-Alem for Natural Preparation Co. Ltd-(Savant) , 2009-2010.

6- Preparation of Novel Compounds With Potential Dyslipidemic Activity, Jordan Company for Antibody Production (MONOJO), 2011.

5- Developing and standardization Gel formula for Premature Ejaculation from Natural plant extract, Al-Alem for Natural Preparation Co. Ltd-(Savant) , 2012-2015.

Projects in Collaboration with Local Universities:

1- Preparation of New indole-2-carboxamides as Potential Hypolipidimic Activity in Triton WR 1339 Model, During sabbatical leave at Al-Zaytooneh Private University, 2007-2008.

2- Preparation of New heterocyclic-2-carboxamides as Potential Hypolipidimic Activity in Triton WR 1339 Model, During sabbatical leave at Al-Zaytooneh Private University, 2014-2015.

3- In vitro evaluation of un-substituted indole carboxamid derivatives as PPAR alpha agonist, in collaboration with Philadelphia University, 2013.

Recent Publications

Publication for associate Professor: 2002-2006

1) Yusuf Al-Hiari, Stephen J. Bennett, Brian Cox, Robert J. Davies, Abedawn Khalaf, Roger D. Waigh and Alan J. Worsley, Steps Toward a Practical Synthesis of Macrocyclic Bisbenzylisoquinolines, Journal of Heterocyclic Chemistry, 42 (4), 647-659, May 2005.

2) Mutasem O. Taha, Khalid M. Aiedeh, Yusuf M. Al-Hiari and Hatim Al-Khatib, Synthesis of Zinc-Crosslinked Thiolated Alginic Acid Beads and their In Vitro Evaluation as Potential Enteric Delivery System Utilizing Folic Acid as Model Drug, De Pharmazia, 60 (10), 736-742, Oct. 2005.

3) Yusuf M. Al-Hiari, Ali M. Qaisi, Mustafa M. El-Abadelah and Wolfgang Voelter, Synthesis and Antibacterial Activity of Some Substituted 3-(Aryl)-and 3-(Heteroaryl)indoles, Monatshefte fuer Chemie / Chemical monthly, 137 (2), 243-248, Feb. 2006, (published on line first, 20th Jan 2006).

4) Bassam A. Sweileh and Yusuf M. Al-Hiari*, Successful Synthesis of Industrially Useful Polycarbonates Based on Bisphenol A by Single Phase Organic Solvent Polymerization, Journal of Polymer Research, 13 (3), 181-191, June 2006, (published on line first, 1-12-2005).

5) Yusuf M. Al-Hiari* and Bassam A. Sweileh, Synthesis of Substituted Benzyl-N-acyl-1,2,3,4-Tetrahydroisoquinoline Derivatives and Investigation the Lithiation-Alkylation Chemistry, Saudi Pharmaceutical Journal , 13 (4) supplement, 34-35, Nov. 2005.

6) Yusuf M. Al-Hiari* and Bassam A. Sweileh, Novel Synthesis and Antimicrobial Activity of 3,7-Dimethylphenoxathiin Nucleus and Some Related Analogues, Asian Journal of Chemistry, 18 (3), 2285-2298, July 2006.

7) Yusuf M. Al-Hiari, Monther A. Khanfar, Ali M. Qaisi, Mohammad Y. Abu Shuheil, Mustafa M. El-Abadelah and Roland Boese, Heterocycles [h]Fused Onto 4-Oxoquinolines. Part I. Synthesis of 6-Oxo-6,9-dihydro[1,2,5]oxadiazolo[3,4-h]-quinoline-7-carboxylic acid N-oxide, Heterocycles, 68(6), 1163-1172, June 2006. ( published on line first 18th April 2006).

8) Ali M. Qaisi, Yusuf M. Al-Hiari*, Jalal A. Zahra, and Mustafa M. El-Abadelah, Pyrido[2,3-f]Quinoxalines-8-Carboxylic Acid Derivatives and their Isomeric Pyrido[2,3-g]Quinoxalines, A Process for their Preparation and their Use as Potential Antibacterial Compounds, Jordan Patent 2323, Feb 2006, (priority date 12/5/2005).

9) Yusuf M. Al-Hiari*, Ali M. Qaisi, Jalal A. Zahra, Mona R. Hassuneh and Mustafa M. El-Abadelah, [a]Fused Heterocyclic-Pyrido[2,3-f]Quinoxaline-2-Carboxylic Acid Derivatives and their Pyrido[3,2-g] Analoges, A Procces for their Preparation and their Potential Uses as Anticancer and Antibacterial Agents, Jordan Patent 2345, May 2006, (priority date 12/4/2005).

Publication for full Professor: 2006-2011

10) Ali M. Qaisi, Yusuf M. Al-Hiari*, Jalal A. Zahra, and Mustafa M. El-Abadelah, Antibacterial Agents, European Patent Application; EP 1 721 898 A1, Nov. 2006.

11) Khaled M. Aiedeh, Mutasem O. Taha, Yusuf Al-Hiari, Yasser Bustanji, Hatim S. AlKhatib, Effect of Ionic Cross-linking on the Drug Release Properties of Chitosan Diacetate Matrices, Journal of Pharmaceutical Sciences, 96 (1), 38-43, 2007. (accepted, Aug. 2006).

12) Ashok K. Shakya, Yusuf M. Al-Hiari and Omran M.O. Al-Hamami, Liquid Chromatographic Determination of Irbesartan in Human Plasma, Journal of Chromatography B, 245-250, 848, 2007, (accepted Oct. 2006)).

13) Yusuf M. Al-Hiari* , Inas Saleh Al-Mazari , Ashok K. Shakya, Rula M. Darwish, and Rana Abu-Dahab, Synthesis and Antibacterial Properties of New 8-Nitro fluoroquinolone Derivatives, Molecules, 12, 1240-1258, 2007. (available on line).

14) Mohammad Y. Abu Shuheil, Mona R. Hassuneh, Yusuf M. Al-Hiari, Ali M. Qaisi, and Mustafa M. El-Abadelah. Heterocycles [h] -fused onto 4-oxoqinoline-3-carboxylic acid, III. Facile synthesis and antitumor activity of model heterocycles [a] fused onto pyrido [2,3-f]quinoxaline-3- carboxylic acids, Heterocycles 2007, 71 (10), 2155-2172.

15) Yusuf M. Al-Hiari, Ali M. Qaisi , Mohammad Y. Abu Shuheil, Mustafa M. El-Abadelah , and Wolfgang Voelter. Synthesis and Antibacterial Potency of 4-Methyl-2,7-dioxo-1,2,3,4,7,10-hexahydropyrido[2,3-f]quinoxaline-8-carboxylic acid, Selected [a]-Fused Heterocyles and Acyclic Precursors, Zeitschrift fuer Naturforschung, B: Chemical Sciences , 62b (11), 1453-1458; 2007.

16) Yusuf M. Al-Hiari* , Inas Saleh Al-Mazari , Ashok K. Shakya†, Rula M. Darwish, and Rana Abu-Dahab, Synthesis and Antibacterial Properties of New 8-Nitro fluoroquinolone Derivatives, Turkish Journal of Pharmaceutical Sciences, Special Issue, 38-39, 2007.

17) Bassam A. Sweileh, Yusuf M. Al-Hiari and Khaled M. Aiedeh, A New Nonphosgene Route to Poly(bisphenol-A carbonate) by Melt Phase Interchange Reactions of Alkylene Diphenyl Dicarbonates with Bisphenol A, Journal of Applied polymer sciences, 110(4), 2278-2292, 2008 (Accepted 11 May 2008, on line 15 Aug 2008).

18) Yusuf M. Al-Hiari, Rana Abu-Dahab and Mustafa M. El-Abadelah, Heterocycles [h]-Fused Onto 4-Oxoquinoline-3-Carboxylic Acid, Part VIII [1]. Convenient Synthesis and Antimicrobial Properties of Substituted Hexahydro[1,4]diazepino[2,3-h]quinoline-9-carboxylic acid and Its Tetrahydroquino[7,8-b]benzodiazepine Analog, Molecules, 13, 2871-2884, 2008.

19) Yusuf M. Al-Hiari*, Bassam A. Sweileh , Ashok K. Shakya, Ghassan Abu Sheikha, Sabah I. Almuhtaseb, Synthesis of 1-Benzyl-1,2,3,4-Tetrahydroisoquinoline, Part I: Grignard Synthesis of 1-(Substitutedbenzyl)-1,2,3,4-Tetrahydroisoquinoline Models with Potential Antibacterial Activity, Jordan Journal of Pharmaceutical Sciences, 2(1), 1-21, 2009.

20) Tariq M. Al-Qirim, Ghassan F. Shattat, Moyad J. Shahwan, Yusuf M. Al-Hiari, Ghassan M. Abu Sheikha and Syed Zaidi, Pharmacological Evaluation of Novel Indole-2-carboxamides As Potent Lipid-Lowering Agents in Triton-WR1339-Induced Hyperlipidemic Rats, Zeitschrift für Naturforschung 64c (9/10), 619-625, 2009 ( accepted July 2009).

21) Al-Qawasmeh, Raed A.; Zahra, Jalal A.; Khanfar, Monther A.; Al-Hiari, Yusuf M.; El-Abadelah, Mustafa M.; Voelter, Wolfgang. A convenient synthesis of 1-alkyl-7-chloro-6-fluoro-3-nitro-4-quinolones. Letters in Organic Chemistry (2009), 6(6), 511-514.

22) Ghassan Shattat, Tariq Al-Qirim, Kamal Sweidan, Moyad Shahwan, Waseem El-Huneidi, Yusuf Al-Hiari, The Hypolipidaemic Activity of Novel Benzofuran-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidaemic Rats: A Comparison with Bezafibrate, Journal Of Enzyme Inhibition And Medicinal Chemistry, 25(6), 751-755, 2010 (accepted 25th Sep. 2009).

23) Moyad Shahwan, Ghassan Shattat, Tariq Al-Qirim, Ghassan Abu Sheikha, Yusuf Al-Hiari, Waseem El-Huneidi, Anan Jarab and Manal AL-Najdawi. Synthesis and Pharmacological Evaluation of Novel Substituted and Unsubstituted N-(benzoylphenyl)-1H-indole-2-carboxamides As Potent Anti-Hypertriglyceridemic Agents, Zeitschrift für Naturforschung 65c (5/6) , 309-316, 2010 ( accepted Feb. 2010).

24) S. AbuRuz , M. Al-Ghazawi1, Y. Al-Hiari, Dried blood spot liquid chromatography assay for therapeutic drug monitoring of lamotrigine, Chromatographia, 71(11/12), 1093-1099, 2010.

25) Yusuf Mohammad Al-Hiari,, Amjad M. Qandil, Rufaida M. Al-Zoubi, Muhammed H. Alzweiri, Rula M. Darwish, Ghassan F. Shattat and Tariq M. Al-Qirim, 7-(3-Chlorophenylamino)-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Molbank, M669: 1-3, 2010.

26) Bassam A. Sweileh ,*, Yusuf M. Al-Hiari , Mohammad H. Kailani and Hani A. Mohammad , Synthesis and Characterization of Polycarbonates by Melt Phase Interchange Reactions of Alkylene and Arylene Diacetates with Alkylene and Arylene Diphenyl Dicarbonates, Molecules, 15, 3661-3682, 2010.

27) Ghassan F. Shattat, Tariq M. Al-Qirim, Moyad J. Shahwan, Yusuf M. Al-Hiari, Ghassan M. Abu Sheikha, N-substituted-1H-indole-2-carboxamide derivatives, a process for their preparation and their use as potential antihyperlipidaemic agents, JP 2519, 13/7/2010. priority number:Jordan Patent ا ع -2008-373 - (date 14/8/2008), file number 35204.

28) Ghassan Shattat, Rania Al-Qirim, Yusuf Al-Hiari, Ghassan Abu Sheikha, Tariq Al-Qirim, Waseem El-Huneidi and Moyad Shahwan. Synthesis and Anti-hyperlipidemic Evaluation of N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339 Induced Hyperlipidemic Rats, Molecules, 15, 5840-5849, 2010.

29) Yusuf M. Al-Hiari, Ashok K. Shakya, Muhammed H. Alzweiri, Tariq M. Al-Qirim, Ghassan F. Shattat and Mustafa M. El-Abadleh, Synthesis and Antibacterial Properties of New N4- acetylated Hexahydro-2,7-dioxopyrido[2,3-f]quinoxaline-8-carboxylic acids, Journal Of Enzyme Inhibition And Medicinal Chemistry, 26(5), 649-656, 2011 (accepted 17th Nov. 2010), Published on line 11-1-2011, DOi number doi:10.3109/14756366.2010.543421.

30) Ghassan Abu Sheikha, Buthina Hussin, Yusuf Al-Hiari, Tariq Al-Qirim, Ghassan Shattat, Synthesis of Benzothiophene Carboxamide Derivatives and Their Pharmacological Evaluation as Potent lipid-Lowering Agents in Rats, Zeitschrift für Naturforschung 66 c , 93-103, 2011 ( accepted Nov. 2010).

31) Rana Abu-Huwaij, Rana M. Obaidat, Kamal Sweidan, and Yusuf Al-Hiari, Formulation and In Vitro Evaluation of Xanthan Gum or Carbopol 934-Based Mucoadhesive Patches, Loaded with Nicotine, AAPS PharmSciTech, 12(1), 21-27, 2011 ( accepted 22 October 2010).

32) Rana M Obaidat, Kamal Sweidan, Wafa Al-Rajab, Mai Khanfar, Rana Abu-Hwaij, Yusuf Al-Hiari and Samir Al-Gharabli, Development of local,mucoadhesive, sustained release patches of tetracycline hydrochloride for treatment of mouth infections: a preliminary in vitro study, European Journal of Parenteral & Pharmaceutical Sciences 15(4): 87-94, 2010 ( accepted 2010).

33) Tariq M. Al-Qirim, Ghassan F. Shattat, Kamal Sweidan, Ghassan M. Abu Sheikha, Yusuf M. Al-Hiari, BENZOFURAN- AND BENZOTHIOPHENE-2-CARBOXAMIDE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS POTENTIAL ANTIHYPERLIPIDAEMIC AGENTS, Jordan Patent 2588- 02/6/2011. (priority date 9/12/2009), JP 2588 approved 27-2-2011,

34) Yusuf M. Al-Hiari*, Ali M. Qaisi, Jalal A. Zahra, Mustafa M. El-Abadelah and Mona R. Hassuneh, Anticancer and Antibacterial Agents, GB UK Patent, GB 2442 951, 23Feb, 2011. (Date of publication: 23. 4. 2008).

35) Al-Qirim, Tariq; Shattat, Ghassan; Abu Sheikhaa, Ghassan;Al-Hiari, Yusuf, Synthesis of Benzothiophene Carboxamide Derivatives and Their Pharmacological Evaluation as Potentantihyperlipidimic Agents in Rats 42nd Central Regional Meeting of the American Chemical Society, Indianapolis, IN, United States, June 8-10 (2011), CERM-281. 

36) Yusuf Al-Hiari *, Ghassan Shattat , Tariq Al-Qirim, Waseem El-Huneidi, Ghassan Abu Sheikha and Suhair Hikmat, Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats, Molecules, 16, 8292-8304, 2011; (doi:10.3390/molecules16108292).

37) Talal Aburjai, Muhammed Alzweiri, Yusuf M. Al-Hiari, Temperature and pressure behaviours of methanol, acetonitrile/water mixtures on chromatographic systems, American Journal of Analytical Chemistry, 2(8), 934-937, 2, 2011.

Publication after 2012

38) Yusuf M. Al-Hiari1*, Amjad M. Qandil, Rufaida M. Al-Zoubi1, Muhammed H. Alzweiri, Rula M. Darwish, Ghassan F. Shattat4 4 and Tariq M. Al-Qirim, Synthesis and Antibacterial Activity of Novel 7-

haloanilino-8-nitrofluoroquinolone Derivatives, Medicinal Chemistry Research, 21, 1734-1740, 2012 (accepted 1-6-2011), ( Online Springer Publisher: DOI: 10.1007/s00044-011-9692-3).

39) Ghassan Shattat, Tariq Al-Qirim, Ghassan Abu Sheikha, Yusuf Al-Hiari, Kamal Sweidan, Rania Al-Qirim, Suhair Hikmat, Luma Hamadneh, and Sameer Al-kouz, The Pharmacological Effects of Novel 5-fluoro-N-(9,10-dihydro-9,10-dioxoanthracen-8-yl)-1H-indole-2-carboxamide Derivatives on Plasma Lipid Profile of Triton-WR-1339-Induced Wistar Rats, Journal Of Enzyme Inhibition And Medicinal Chemistry, 28(4), 863-869, 2013 (accepted 26th April. 2012, Early Online: 1–7, Published on line 00-0-2012, DOI: 10.3109/14756366.2012.692085.

40) Muhammed Alzweiri, Yusuf M. Al-Hiari, Talal Aburjai and Osama Abdel-Aldaem, On-column approach in HPLC-UV analysis of non-chromophoric compounds using azelaic acid as a model, Jordan Journal of Pharmaceutical Sciences, 5(3), 243-251, 2012, accepted May 2012.

41) Mohammad H. Kailani, Amal G. Al-Bakri, Haitham Saadeh, Yusuf M. Al-Hiari, Preparation and Antimicrobial Screening of Novel 2, 2-dichloro-cyclopropane –cis-dicarbamates and Comparison to their Alkane and cis-Alkene Analogs, Jordan Journal of Chemistry 7(3), 239-252, 2012, accepted Sep. 2012.

Publication after 2013

42) Muhammed Alzweiri, Yusuf M. Al-Hiari, Evaluation of vanillic acid as inhibitor of carbonic anhydrase isozyme III by using a modified Hummel-Dreyer method: approach for drug discovery, Biomedical Chromatography, 27(9), 1157-1161, 2013, accepted March 2013

.

43) Shattat, Ghassan; Al-Qirim, Tariq; Sheikha, Ghassan Abu; Al-Hiari, Yusuf; Sweidan, Kamal; Al-Qirim, Rania; Hikmat, Suhair; Hamadneh, Lama; Al-kouz, Sameer The Pharmacological effects of novel 5-fluoro-N-(9,10-dihydro-9,10-dioxoanthracen-8-yl)-1H-indole-2-carboxamide derivatives on plasma lipid profile of Triton-WR-1339-induced Wistar rats , Journal of Enzyme Inhibition and Medicinal Chemistry , 28(4), 863-869, 2013.  

44) Muhammed Alzweiri, Yusuf M. Al-Hiari, Analysis and Evaluation of Hydroxytyrosol in Olive Leaf Extract, Jordan Journal of Pharmaceutical Sciences, 6(3), 314-322, 2013.

Publication after 2014

45) Yusuf M. Al-Hiari • Violet N. Kasabri • Ashok K. Shakya , Muhammad H. Alzweiri • Fatma U. Afifi •

Yasser K. Bustanji • Ihab M. Al-Masri, Fluoroquinolones: novel class of gastrointestinal dietary lipid digestion and absorption inhibitors, Medicinal Chemistry Research, 23(7), 3336-3346, 2014 (accepted 9-1-2014), ( published online: 24/1/2014; Springer Publisher: DOI: 10.1007/s00044-014-0913-4).

46) Manal AL-Najdawi, Yusuf Al-Hiari, Tariq Al-Qirim, GhassanShattat, Mohammad Al-Zweri, and Ghassan Abu Sheikha, Synthesis and Pharmacological Evaluation of Novel Unsubstituted Indole-Anthraquinone Carboxamide Derivatives as Potent Antihyperlipidemic Agents, Zeitschrift für Naturforschung 69C, 69(1/2), 21-28, 2014. (accepted Jan 21, 2014).

47) Al-Hiari, Yusuf M.; Shakya, Ashok K.; Alzweiri, Muhammed H.; Aburjai, Talal; Abu-Dahab, Rana, Synthesis and biological evaluation of substituted tetrahydro-1H-quino[7,8-b][1,4]benzodiazepine-3-carboxylic acid derivatives , Farmacia (2014), 62(3), 570-588.

48) Alzweiri Muhammed; Al-Balas Qosay; Al-Hiari Yusuf, Chromatographic evaluation and QSAR optimization for benzoic acid analogues against carbonic anhydrase III, Journal of enzyme inhibition and medicinal chemistry (2014), 420-429. DOI: 10.3109/14756366.2014.940939

49) Al-Qirim T; Shattat G; Sheikha G A; Jarab A; Sweidan K; Al-Hiari Y, Synthesis of Novel N-(4-benzoylphenyl)-2-furamide Derivatives and their Pharmacological Evaluation as Potent Antihyperlipidemic Agents in Rats, Drug research, 65(3), 158-163, 2015. DOI: 10.1055/s-0034-1375646

50) Sanaa K. Bardaweel, Rula M. Darwish, Muhammed H. Alzweiri and Yusuf M. Al-Hiari, Synergism and efficacy of some naturally occurring D-amino acids against clinically relevant bacterial and fungal species, Jordan Journal of Pharmaceutical Sciences, 7(3), 199-2012, 2014.

51) Suhir Jasim, Tariq Al-Qirim, Ghassan Shattat, Ghassan AbuSheika, Nadeem Alhusini, Yusuf Al-Hiari, The Pharmacological effect of Novel N-(5-Chloro-9,10-Dioxo-9,10-Dihydroanthracen-1-yl)Furan-2-carboxamide Derivatives on Lipid Metabolism in Triton Induced Rats, SYLWA, 158, 9, 122-128, 2014.

Publication after 2015

52) Alzweiri M*, Shudeifat M, Al-Khaldi K, Al-Hiari Y, Afifi F. U, Acetylated ferulenol-oxy-ferulenol as a proposed marker for fresh ferula toxicity: A metabolomic approach, : Journal of Liquid Chromatography & Related Technologies, accepted march (2015), 38(2), 283-288.

53) Kamal Sweidana,*, Jörn Engelmannb, Walid Abu Rayyanc, Dima Sabbahc, Musa Abu Zargaa, Tariq Al-Qirimc, Yusuf Al-Hiarid, Ghassan Abu Sheikhac, Ghassan Shattatc, Synthesis and Preliminary Biological Evaluation of New Heterocyclic Carboxamide Models, LLDD, 12, 417-429, 2015.

54) Muhammed Alzweiri · Mohammad Khanfar , Yusuf Al-Hiari, Variations in GC–MS Response Between Analytes and Deuterated Analogs, Chromatographia 78:251–258, 2015.

55) Ghassan F. Shatat, Ghassan M. Abusheika, Tariq M. Al-Qirm, Rawan Huiwaitat, Waseem El-Huneidi, Reema Abu Khalaf, Yusuf M. Al-Hiari , Suhair H. Jasim & Lama Hamadaneh, Novel Pyrrole Derivatives as Potent lipid-Lowering Agents in Triton-WR-1339-Induced Hyperlipidemic Rats, Lat. Am. J. Pharm. 34 (6): 1258-64 (2015).

56) Emad M. Abdullat, Nathir M Obeidat Madi T Al-Jaghbir .Yusuf M Al-Hiari. Kamal Al- Hadidi. Establishing the Cholinesterase Levels in Jordan: an investigation and monitoring model for pesticides outbreak. Jordan Medical Journal 2015; 49(3):129-138.

57) Mohammad Mohammad, Violet Kasabri, Hiba Zalloum, Rabab Tayyem3, Eman AbuRish, Yusuf Al-Hiari, Yasser Bustanji, Antilipolytic property of curcumin: Molecular docking and kinetic assessment, REVUE ROUMAINE DE CHIMIE, 1-10, 60(10), 2015.

58) Yusuf M. Al-Hiari, Ashok K. Shakya, Wafa J. Al-Rajab, Emad A. AbdelRahim, Muhammed H. Alzweiri, Lubna Rustam and Rula Darwish, Antimicrobial screening of novel N-4-fluorophenyl quino-[7,8-b][1,4]-benzodiazepin-3-carboxylic acid derivatives, REVUE ROUMAINE DE CHIMIE, 899-905, 60(9), 2015.

Publication after 2016:

Three papers are accepted and 3 in process

59) Nada Jarrar, Muhammed Alzweiri, Yusuf Al-Hiari, Shrouq Farah, Mohammad A. Khanfar, Modified Hummel–Dreyer methodand Molecular Modeling Studies Identified Nicotinic Acid Analogues as Carbonic Anhydrase III Ligands, LLDD, 13 (5), 401-410, 2016. DOI: 10.2174/1570180812666150821002900

60) Shereen ARABIYAT, Yusuf AL-HIARI, Yasser K. Bustanji, Hiba ZALLOUM, Violet Kasabri; In Vitro Modulation of Pancreatic Lipase and Proliferation of Obesity Related Colorectal Cancer Cell line Panel by Novel Synthetic Triazoloquinolones, REVUE ROUMAINE DE CHIMIE, accepted June 2016, 61(11-12), 871-879, 2016.

61) Abu Farha, Rana; Bustanji, Yasser Kh; Al-Hiari, Yusuf M; Al-Qirim, Tariq M; abu-sheikha, Ghassan; albashiti, rabab, Lipid Lowering Activity of Novel N-(benzoylphenyl)pyridine-3-carboxamide derivatives in Triton WR-1339 Induced Hyperlipidemic Rats, Journal Of Enzyme Inhibition And Medicinal Chemistry. 31(4), 138-144, 2016 accepted. 2016. DOI:10.1080/14756366.2016.1222581

62) Amal AbuHanoud, Violet Kasabri, Naiyla Bulayova, Amal akour, Haidar Bustanji, Nahla Khawaja, Dana Hyasat, , Yasser Bustanji, Yusuf AlHiari, Rula Silawi; " Evaluation of Oxytocin (OXT), Endothelin-1 and Nesfatin Plasma Concentrations in Newly-diagnosed Diabetic and Non-diabetic Patients with Metabolic Syndrome. "' Jordan Journal of Pharmaceutical Sciences, 00, 00-00, 2016 accepted. 2016.

63) Shereen Arabiyat, Ashraf Al-Rabi'ee, Hiba Zalloum, Violet Kasabri, Mohammad Hudaib, Mohammad Mohammad, Yusuf Al-Hiari and Yasser Bustanji ''Antilipolytic and hypotriglyceridemic effects of dietary Salvia triloba Lf (Lamiaceae) in experimental rats''. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH 2016; 15(4):723-728

Publication 2017:

64) Luay Abu-Qatouseh, Mohammad Abu-Sini, Amal Mayyas , Yusuf Al-Hiari , Rula Darwish and Talal Aburjai, Synthesis of New Nitrofluoroquinolone Derivatives with Novel Anti-Microbial Properties against Metronidazole Resistant H. pylori, Molecules. 22(1), 71, 2017 accepted. Dec. 2016. doi:10.3390/molecules22010071.

65) Suhair Hikmat , Tariq Al-qirim , Dania Alkabbani , Ghassan Shattat , Ghassan Abu Sheikha , Dima Sabbah , Reema Abu khalaf and Yusuf Al-hiari ; Synthesis and In vivo Anti-hyperlipidemic Activity of Novel N-Benzoylphenyl-2-Furamide Derivatives in Triton-WR-1339-Induced Wistar Rats; Trop J Pharm Res, 16(1), 193-201, 2017 (accepted Oct 2016).

66) Haneen K. Mohammad, Muhammed H. Alzweiri, Mohammad A. Khanfar, Yusuf M. Al-Hiari; 6-Substituted nicotinic acid analogues as potent inhibitors of CAIII as therapeutic candidates in hyperlipidemia and cancer, Medicinal Chemistry Research, 26, (7), pp 1397–1404 (accepted 28 2 2017-Springer Publisher: DOI: 10.1007/s00044-017-1825-x

67) Lama Hamadneh, Luay Al-Essa, Suhair Hikmat, Tariq Al-Qirim, Ghassan Abu Sheikha, Yusuf Al-Hiari, Nisrin Azmy, Ghassan Shattat, N-(3-Benzoylphenyl)-1H-Indole-2-Carboxamide Decreases Triglycerides Levels by Down Regulation of Apoc3 Gene Expression in Acute Hyperlipidemic Rat Model , Molecular and Cellular Biochemistry (Mol Cel Biochem), 431(1-2), 133-138, July. 2017. DOI 10.1007/s11010-017-2983-3.

68) Muhammed Alzweiri, Sara Al-Marabeh, Sanaa K. Bardaweel, Rawhi Alfar and Yusuf M. Al-Hiari, Stability determination for cyclized 2,4-dinitrophenyl hydrazone derivative of glucose, Journal of Analytical Science and Technology, 8:9 (0, 1-8, accepted 5th April. 2017. DOI 10.1186/s40543-017-0117-x.

69) Mohammad Abu-Sini, Amal Mayyas, Nehaya Al-Karablieh, Rula Darwish , Talal Aburjai, Yusuf Al-Hiari, Shereen Arabiyat, Luay Abu-Qatouseh, Synthesis of 1,2,3-Triazolo[4,5-h]quinolone Derivatives with Novel Anti-Microbial Properties against Metronidazole Resistant Helicobacter pylori, Molecules. 22(5), 841, 2017 accepted. Dec. 2016. doi:10.3390/molecules22050841. Accepted 15 5 2017.

70) Arabiyat S., Kasabri V., Al-Hiari Y., Bustanji Y., Albashiti R., Almasri I. and Sabbah D., (2017), antilipase and antiproliferative activities of novel fluoroquinolones and triazolofluoroquinolones. Chemical Biology and Drug Design 90(6), 1282-1294, 2017 Dec. 2017 (DOI: 10.1111/cbdd.13049).

71) Lubna Swellmeen, Rand Shahin, Yusuf Al-Hiari, Amani Alamiri, Alaa Hasan, Omar Shaheen, Structure based drug design of Pim-1 kinase followed by pharmacophore guided synthesis of Quinolone-based inhibitors. Bioorganic & Medicinal Chemistry (BMC), 25(17), 4855-4875, 21 July 2017. https://doi.org/10.1016/j.bmc.2017.07.036, Available online 21 July 2017. DOI: 10.1016/j.bmc.2017.07.036

72) Rana Abu Farha, Yasser Bustanji, Yusuf Al-Hiari, Sanaa K. Bardaweel, Tariq Al-Qirim, Ghassan Abu Sheikha, Rabab Albashiti , Pharmacological Evaluation of Novel Isonicotinic Carboxamide Derivatives as Potential Anti-hyperlipidemic and Antioxidant Agents, Archiv der Pharmazie/ Arch. Pharm. Chem. Life Sci, 350, e1700024, 2017. Accepted 21 july 2017, DOI 10.1002/ardp.201700024.

73) Rama Kahwaji, Violet Kasabri,* 1 Nailya Bulatova, Amal Akour, Haidar Bustanji, Nahla Khawaja, Dana Hyasat, Ayman Zayed, Munther Momani, Yasser Bustanji, Yusuf AlHiari, Sundus Mashallah, Mais Al-Nouaaimi , Evaluation of correlations of Plasma Levels of Oxytocin, Omentin-1 and Irisin in Diabetic and Non-Diabetic Metabolic Syndrome Patients: A Cross Sectional Study in Jordan, Jordan Medical Journal, J Med J 2017; Vol. 51 (3):97-108).

Publication after 2018:

74) Yousef Alabsi, Yusuf Al-Hiari, Violet Kasabri, Shereen Arabiyat, Rabab Bashiti, Sundos Alalawi And Rula Al-Shahrabi; '' In Vitro Modulation Of Pancreatic Lipase And Proliferation Of Obesity Related-Colorectal Cancer Cell Line Panel By Novel Synthetic Fluoroquinolones ''. REVUE ROUMAINE DE CHIMIE 2018, 63(12), 1123-1134.

75) Ghassan Abu Sheikha, Majdi M. Bkhaitan, Hanin Kalloush, Lama Hamadneh, Reema Abu Khalaf, Tariq Al-Qirim, and Yusuf Al-Hiari. Synthesis of Novel Benzimidazole-2-Carboxamide Derivatives and In Vivo Antihyperlipidemic Activity Evaluation. Chem. Pharm. Bull..;66(4):423-426, Accepted, JAN. 2018. doi: 10.1248/cpb.c17-00908.

Publication after 2019:

76) Tanzeela Abdul Fattah, Aamer Saeed, Yusuf M. Al-Hiari, Violet Kasabri, Ihab M. Almasri, Sundos AlAlawi, Fayaz Ali Larika and Pervaiz Ali Channara ‘’Functionalized Furo[3,2-c]coumarins as Anti-proliferative, Anti-lipolytic, and Anti-inflammatory Compounds: Synthesis and Molecular Docking Studies’’. JOURNAL OF MOLECULAR STRUCTURE 2019; 1179:390-400.

77) Mamdooh N, Kasabri V, Al-Hiari Y, Almasri I, Al-Alawi S, Bustanji Y’’ Evaluation of selected commercial pharmacotherapeutic drugs as potential pancreatic lipase inhibitors and antiproliferative compounds. DRUG DEVELOPMENT RESEARCH. 2019 ;80(3):310-324. DOI: 10.1002/ddr.21499.

78) Imad I. Hamdan, Violet Kasabri, Yusuf M. Al-Hiari, Dina ElSabawi, Hiba Zalloum;’’ Lipase inhibitory activity of selected pharmaceutical agents’’; ACTA PHARMACEUTICA . 2019; 69:1–16. Original research paper. https://doi.org/10.2478/acph-2019-0010.

79) Manal Al-Najdawi, Bilal Al-Jaidi, Qosay Al-Balas, Haifa'a Odetalla, Tariq Al-Qirim, Ghassan Shattat and Yusuf Al-Hiari, Synthesis, molecular docking and evaluation of hypolipidemic activities of novel benzophenonecarboxamide derivatives, Indian Journal of Chemistry/ IJC-B Vol.58B (05) [May 2019], 587-593, 2019.

80) Shereen Arabiyat ; Violet Kasabri; Yusuf Al-Hiari; Ihab AL-MASRI; Sundus Alalawi; YASSER BUSTANJI,

DUAL GLYCATION-INFLAMMATION MODULATION, DPP-IV AND PANCRAETIC LIPASE INHIBITORY POTENTIALS AND ANTIPROLIFERATIVE ACTIVITY OF NOVEL FLUOROQUINOLONES, Asian Pacific Journal of Cancer Prevention (APJCP), V 20, Issue 8, August 2019, 2503-2514. Accepted 18/8/2019. DOI: 10.31557/APJCP.2019.20.8.2503.

81) Lubna Swellmeen*, Amal Uzrail, Rand Shahin and Yusuf AL-Hiari; Synthesis of Fluoroquinolones Derivatives as Antimicrobial Agents, Oriental Journal of Chemistry (Orient J Chem), 35(4), 1248-1253; 2019. DOI : http://dx.doi.org/10.13005/ojc/350401.

82) Aya Qasem , Violet Kasabri, Eman AbuRish, Yasser Bustanji, Yusuf Al-Hiari,Reem AlAbbasi, Bashaer AbuRmilha , Sundus Alalawi ‘’ EVALUATION OF POTENTIAL CYTOTOXIC EFFECT OF DIFFERENT PROTON PUMP INHIBITORS ON DIFFERENT HUMAN CANCER CELL LINES’’. ANTICANCER AGENTS IN MEDICINAL CHEMISTRY ACCEPTED/2019.

83) Alaa Hamdan, Violet KASABRI, Yusuf Al-Hiari, Shereen ARABIYAT, Sundus ALALAWI’’ Dual Anti-Inflammatory And Anti-Glycation propensities of A Potentially Novel Class of Functionalized Flouroquinolones’’ Journal of Heterocyclic Chemistry, JHC , 00(0), 0000-000; 2019. ; accepted 7/10/2019.

84) Amani Al-Ma’ani, Yusuf Al-Hiari, Violet Kasabri, Noor Mamdooh, Sundus Alalawi & Ahmad Telfah, FUNCTIONALISED TRIAZOLOQUINOLONES AS A POTENTIALLY NOVEL CLASS OF ANTIDIABESITY AND ANTIPROLIFERATIVE COMPOUNDS: SYNTHESIS AND PHARMACOLOGICAL APPRAISAL, Analytical Chemistry Letters,  Volume 9 (6) -000, 2019. Published Online: 28 Jan 2020.

Publication after 2020:

85) Mthanna AlKhalil, Yusuf Al-Hiari, Shereen Arabiyat, Violet Kasabri, Shereen Arabiyat, Muhammad Al-Zweiri, Noor Mamdooh, Ahmad Telfah;’’ Selected Pharmacotherapy Agents as Antiproliferative and anti-inflammatory compounds’’, DRUG DEVELOPMENT RESEARCH , 000,000, 2020. Puplished on line fiesrt 14/1/2020.

86) Shereen ARABIYAT, Violet Kasabri, Yusuf AL-HIARI, ‘’Antilipolytic-Antiproliferative Activity Of Novel Antidiabesity Triazolo/Fluoroquinolones’’. Jordan Journal of Pharmaceutical Sciences, Volume 13, (1), 85-100, 2020, accepted 19/3/2019.

· MAHA R. AL RIMAWI1,*, , YUSUF M. AL-HIARI2, , AMAL G. AL-BAKRI3, and SANAA K. BARDAWEEL, . Antibacterial and Anticancer Properties of New Fluoroquinolones, Asian Journal of Chemistry; Vol. 32, No. 2, 427-434, 2020.

Submitted 2020

87) Rula AL-SHAHRABI, Violet KASABRI, Yusuf Al-Hiari, Shereen ARABIYAT, Sundus ALALAWI’’ Functionalized Flouroquinolones As A Potentially Novel Class Of Anti-Inflammatory And Anti-Glycation Compounds: Synthesis And Pharmacological Appraisal’’ ANALYTICAL CHEMSITRY LETTERS submitted 2/2019.

88) Abdelrahman

89) Shereen p chloro telfah and maliti

Violet Kasabri, Shereen ARABIYAT, Hiba ZALLOUM, Yusuf AL-HIARI, Yasser K. BUSTANJI, Sundos MASHALLA, Ahmad TELFAH, Jehad ALMALITI; ‘’Synthesis, docking studies and evaluation of novel fluoroquinolones as potential antidiabesity and antiproliferative compounds’’ ANTICANCER AGENTS IN MEDICINAL CHEMISTRY. Submitted 2/2018

90) Abdurahman paper submitted EJMC 9 2019

91) Shireen ahmd jihad-apioptosis ---pCl,p-F

92) Ofloxacin tolfah

93) Lubna MCRE

94) Manal 2

95) Imad FQ pl m-Methyl maha

96) Sarah 1

97) Sarah 2 apioptosis

98) Someya

99) Rola

100) Ala a tabaza 1 and 2

101) Ala a tabaza 1 and 2

102) yarmook

Published Papers/Posters/Abstracts in Scientific Conferences:

1. Yusuf Al-Hiari* and Roger D. Waigh, Novel Synthesis of Bisbenzylisoquinoline Alkaloids, The 24th RSC Perkin Division For Scotland, Poster and abstract, 18th of Feb 1998-Saint Andrew University / Dundee, Scotland.

2. Yusuf Al-Hiari* and Roger D. Waigh, Steps Toward an Efficient Synthesis of New Biologically Active Bisbenzylisoquinoline Alkaloids, The 2nd International Conference of the Faculty of Pharmacy, October, 2001, Amman-Jordan, and the 5th Scientific Congress of the Association of the Colleges of Pharmacy in the Arab World , Poster and abstract, October, 2001, Amman-Jordan.

3. Yusuf Al-Hiari* and Roger D. Waigh, Steps Toward an Efficient Synthesis of Macrocyclic Bisbenzylisoquinoline Alkaloids, The 10th Pharmaceutical Jordainian Conference of the Jordainian Pharmaceutical Society, Poster, abstract and lecture, March 13-16/2002, Amman-Jordan.

4. Yusuf Al-Hiari*, Pharmaceutical Biotechnology: “Recombinant DNA Technology as a Tool for the Production of Biopharmaceutical Drugs, The Jordan Ninth Science Week: Biotechnology and its Role in the Jordanian Economy, A primary lecturer and abstract, 6-8 October 2003, University of Science and Technology, Irbid-Jordan.

5. Yusuf M. Al-Hiari* and Bassam A. Sweileh, Crignard Synthesis of 1-Substituted Benzyl-1,2,3,4-tetrahydroisoquinoline Models with Potential Antibacterial and Anticancer Activity, The Eleventh Jordainian Pharmacy Conference, Original research paper, abstract and lecture, September 28-30, 2005, Amman-Jordan.

6. Yusuf M. Al-Hiari* and Bassam A. Sweileh, Synthesis of Substituted benzyl-N-acyl-1,2,3,4-Tetrahydroisoquinoline Derivatives and Investigation the Lithiation-Alkylation Chemistry, The 9th International Pharmaceutical Sciences Conference and Exposition and the 9th General Assembly Meeting of the Scientific Society of Colleges of Pharmacy of the Association of Arab Universities in the Arab World, Original research paper, abstract and lecture, 17-21/12/2005, Riyadh- Saudi Arabia.

7. Yusuf M. Al-Hiari* and Dr. Talal Aburjai, Patent Challenges in Pharmaceutical Sector; Impact, Overcoming Challenges and Future Prospective, “The Importance of Intellectual Property in Scientific Research and Economic and Industrial Growth in the Arab World” Original research paper, abstract and lecture, 23-25/1/2006, Damascus-Syria.

8. Ali M. Qaisi, Yusuf M. Al-Hiari*, Jalal A. Zahra, and Mustafa M. El-Abadelah, Novel Biologically Active 2-Quinoxalinone and Benzofuroxan Systems Obtained by Substitution at Position 7 of 8-Nitrofluoroquinolones, Nagazaki Pharmaceutical Conference, July 2006, Nagazaki University, Japan.

9. Yusuf M. Al-Hiari* , Inas Saleh Al-Mazari , Ashok K. Shakya†, Rula M. Darwish, and Rana Abu-Dahab, Synthesis and Antibacterial Properties of New 8-Nitro fluoroquinolone Derivatives, abstract and oral presentation (invited speaker), 5th International Symposium on Pharmaceutical Chemistry, Sep. 5-7, 2007, Istanbul, Turkey.

10. Yusuf M. Al-Hiari*, Ashok K. Shakya, Ghassan Abu Sheikha, Bassam A. Sweileh, Preparation of new diazepino[2,3-h]quinoline-9-carboxylic acid derivatives and their analogus [b]fused benzodiazepine derivatives, The 12th Pharmaceutical Jordainian Conference of the Jordainian Pharmaceutical Society, Full Lecture and abstract, April 10-12/4/2008, Amman, Jordan.

11. Yusuf M. Al-Hiari, Synthesis of Substituted benzyl-1,2,3,4-Tetrahydroisoquinoline Derivatives Originating from Natural Sources: Grignard and Lithiation Approaches, Scientific day of Medicinal, Aromatic and Poisonous Plants, abstract as full lecture, Zarka University College, Al-Balqa’ Applied University, 23, April 2008.

12. Yusuf M. Al-Hiari and Bassam A. Sweileh, Novel Synthesis of Macrocyclic Bisbenzylisoquinoline Models With One Ether Linkage Utilizing Lithiation-Alkylation Approach, Jordan International Pharmaceutical Conference, abstract as full lecture, Al-Zaytoonah Private University of Jordan, 15-17-Oct. 2008.

13. Yusuf M. Al-Hiari Heterocycles [h]-Fused Onto 4-Oxoquinoline-3-Carboxylic Acid, Novel Biologically Active 2-Quinoxalinone Systems Obtained by Substitution at Position 7 of 8-Nitrofluoroquinolones, The Fourth International Conference; Research and Development in Drugs: Current challenges, Pharmaceutical and Drug Industries Division-National Research Centre, abstract as full lecture, Cairo/Egypt, 3-5 March 2009.

14. Bassam A. Sweileh, Yusuf M. Al-Hiari, Mohammad H. Kailani, Synthesis and Characterization of Polycarbonates by Melt-Phase Interchange Reactions of Alkylene and Arylene Diacetates with Alkylene and Arylene Diphenyl Dicarbonates: A New Synthetic Approach, The 9th Jordanian Chemical Conference, The Jordanian Chemical Society, Hashemite University, 28 th April 2009.

15. Yusuf M. Al-Hiari, Pharmaceutical biotechnology: the art of the future, The 13th Pharmaceutical The 13th Jordanian conference of pharmacist of the Jordainian Pharmaceutical Association, Full Lecture and abstract, April 22-24/4/2010, Amman, Jordan.

16. Yusuf M. Al-Hiari, Novel Biologically Active 2-Quinoxalinone Systems Obtained by Substitution at Position 7 of 8-Nitrofluoroquinolones, The 13th Pharmaceutical The 13th Jordanian conference of pharmacist of the Jordainian Pharmaceutical Association, abstract, April 22-24/4/2010, Amman, Jordan.

17. Yusuf M. Al-Hiari, Ashok K. Shakya, Muhammed H. Alzweiri and Mustafa M. El-Abadelah, Formal Synthesis and Antibacterial Properties of New N4- acetylated Hexahydro-2,7-dioxopyrido[2,3-f]quinoxaline- 8-carboxylic acids, The 13th Pharmaceutical The 13th Jordanian conference of pharmacist of the Jordainian Pharmaceutical Association, abstract, April 22-24/4/2010, Amman, Jordan.

18. Yusuf M. Al-Hiari , Manal M Al-Najdawi, and Tariq M. Al-Qirim. Synthesis and Pharmacological Evaluation of Novel N-(benzoylphenyl)-1H-indole-2-carboxamides As Potent Anti-Hypertriglyceridemic Agents. 11th Eurasi Conference on Chemical Sciences, abstract, 6-10 October 2010, the Dead Sea-Jordan. (poster).

19. Yusuf Al-Hiari and Ashok K. Shakya, Synthesis and antibacterial activity of new [1,2,3] triazolo[4,5-h]quinoline derivatives as potential antimicrobial agents. The 3ed Jordanian International Pharmaceutical Conference, abstract and oral presentation, 20-22 October 2010, Al-Zaytoonah Private University of Jordan, Amman-Jordan.

20. Yusuf Al-Hiari and Ashok K. Shakya, "Synthesis and Antibacterial Activity of New [1,2,3] triazolo[4,5-h]quinoline Derivatives as Potential Antimicrobial/AntiTuberculosis Agents". First United Arab Emirates Conference on Pure and Applied Chemistry (ECPAC11), abstract and oral presentation, 1-3/3/2011, American University of Sharjah, Sharjah, UAE.

21. Yusuf Al-Hiari and Ashok K. Shakya: "Synthesis and Antibacterial Activity of New [1,2,3] triazolo[4,5-h]quinoline Derivatives as Potential Antimicrobial /Anti-convulsant Agents". The International Conference on Materials in Jordan, Humboldt Kolleg, abstract and oral presentation, 9-11 April /4/2011, German –Jordanian University (GJU), Amman, Jordan.

22. Yusuf Al-Hiari, " Pyrido-Quinoxalinones, As potentiel antibacterial and anticancer compounds" , The 4th International Conference on Health Care (ICHC), abstract and oral presentation , 4-5 May /5/2011, Al-Ahliyya Amman University,, Amman, Jordan.

23. Al-Qirim, Tariq; Shattat, Ghassan; Abu Sheikhaa, Ghassan; Al-Hiari, Yusuf, Synthesis of Benzothiophene Carboxamide Derivatives and Their Pharmacological Evaluation as Potentantihyperlipidimic Agents in Rats 42nd Central Regional Meeting of the American Chemical Society, Indianapolis, IN, United States, June 8-10 (2011), CERM-281.

24. Yusuf M. Al-Hiari, Rania Al-Qirem and Ghassan F. Shattat, Novel 5-Fluoroindole-2-Carboxamide Derivatives As Potential Antihyperlipidemic Compounds, The 14th Annual Scientific Congress of the Association of the Pharmacy Colleges in the Arab World and the 2nd  International Conference of the College of Pharmacy and Health Sciences, Ajman University of Science and Technology (AUST), oral presentation, AUST- Ajman, UAE, in Feb. 7-9, 2012.

25. Yusuf M. Al-Hiari, Novel Biologically Active 2-Quinoxalinone Systems Obtained by Substitution at Position 7 of 8-Nitrofluoroquinolones, The 13th Pharmaceutical The 13th Jordanian conference of pharmacist of the Jordainian Pharmaceutical Association, abstract, April 22-24/4/2010, Amman, Jordan.

26. G. Shattat, T. Al-Qirim, R. Al-Qirim, Y. M. Al-Hiari, G. Abu Sheikha and E. El-Huneidi, Indole- 2- Carboxamide Derivatives As Novel Anti-hyperlipidemic Agents In Triton Wr-1339- Induced Hyperlipidemic Raqts, The 14th Annual Scientific Congress of the Association of the Pharmacy Colleges in the Arab World and the 2nd  International Conference of the College of Pharmacy and Health Sciences, Ajman University of Science and Technology (AUST), Poster, AUST- Ajman, UAE, in Feb. 7-9, 2012.

27. Yusuf M. Al-Hiari and Ashok K. Shakya, Muhammed H. Alzweiri, Talal A. Aburjai and Nizar M. Mhaidat: "Synthesis and Biological Activities of New 9-cyclopropyl-4-fluoro-3-(4-susbstituted phenyl)-6-oxo-6,9-dihydro-3-H-[1,2,3] triazolo[4,5-h]quinoline -7-carboxylic acid derivatives ”. The Third International Conference of the Faculty of Pharmacy-The University of Jordan, and the 15th Scientific Congress of the Association of the Pharmacy Colleges in the Arab World ,October 9-11, 2012, Amman-Jordan, Oral presentation , Amman-Jordan.

28. Jamila J. Dibas, Fatma U. Afifi and Yusuf M. Al-Hiari " Evaluation of unexplored poppy from the flora of Jordan: Papaver polytrichum Bioss.et Kotschy- Papaveraceae”. The Third International Conference of the Faculty of Pharmacy-The University of Jordan, and the 15th Scientific Congress of the Association of the Pharmacy Colleges in the Arab World ,October 9-11, 2012, Amman-Jordan, poster , Amman-Jordan.

29. Shdeifat M. Al-khaldiK., Al-Zweri M., Afifi Fatma U., and Al-Hiari M. Yusuf " Identification of Ferulenol and 4-hydroxycumarin in Feruka communis samples collected in Jordan using different methods”. The Third International Conference of the Faculty of Pharmacy-The University of Jordan, and the 15th Scientific Congress of the Association of the Pharmacy Colleges in the Arab World ,October 9-11, 2012, Amman-Jordan, poster , Amman-Jordan.

30. Yusuf M. Al-Hiari, Ghassan F. Shattat and Rania Al-Qirem, “Novel 5- Fluoroindole-2 Carboxamide Derivatives as Potential Antilyperlipidaemic Compounds”, 11th International Conference on Chemistry and Its Role in Development, Mansoura - Sharm El Sheikh, Egypt, 11-15 March 2013

31. Yusuf. M. Al-Hiari • Violet N. Kasabri • Ashok K. Shakya , Muhammad H. Alzweiri • Fatma U. Afifi •

Yasser K. Bustanji • Ihab M. Al-Masri, Fluoroquinolones: novel class of gastrointestinal dietary lipid digestion and absorption inhibitors, 15th National Congress of Pharmacy from Romania, XVth edition, 24-27 September, lecture and abstract, Palas Complex, Iași, Romania, 2014.

32. Primary lecturer and round mediator : Yusuf. M. Al-Hiari, Ashok K. Shakya , Muhammad H. Alzweiri, • talal Aburjai, Nizar Mhidat., Triazolo[4,5-h]quinolones as Potential Antimicrobal Agents; The 15th Scientific Congress of the Jordanian Pharmacists Association “Pharmacy Perspectives": An Evolving Role in Community Health, 3-5 April 2014, Amman-Jordan.

33. Primary lecturer : Yusuf M. Al-Hiari, Rania Al-Qirem, Ghassan F. Shattat, Tariq Al-Qirim, and Manal Al-Najdawi, “Novel 5- Substituted indole -2 Carboxamide Derivatives as Potential Antilyperlipidaemic Agents”, The International Conference on Materials in Jordan' Building International network for enhancement of Research in Jordan', Humboldt College, German –Jordanian University (GJU), Amman 3-5 April 2014.

34. Primary lecturer : Yusuf M. Al-Hiari, Nada Jarar, and Muhammad H. Alzweiri , “Nicotonic acid analogues as CAIII inhibitors”, The International Conference on Materials in Jordan' Building International network for enhancement of Research in Jordan', Humboldt College, German –Jordanian University (GJU), Amman 3-5 April 2014.

35. Primary lecturer: Yusuf. M. Al-Hiari, Triazolo[4,5-h]quinolones as Potential Antimicrobal Agents, The Scientefic Day, Al-Zaytoonah private University , Al-Zaytoonah private University, 21 October 2014.

.

36. Primary lecturer and round mediator : Yusuf. M. Al-Hiari & Violet N. Kasabri , New antibacterial fluoroquinolones with potential anti-obesity effects at the Jordan International Pharmaceutical Conference 2015: Al-Zaytoonah private University, 21-23 October 2015, Amman-Jordan.

37. - Lecture and oral presentation: Yusuf. M. Al-Hiari, " Novel 5-substituted indole-2-carboxamide derivatives as potential antihyperlipidaemic Agents" at Second United Arab Emirates Conference on Pure and Applied Chemistry (ECPAC16), American University of Sharjah, , UAE, 1-3/3/2016.

38- Invited and guest speaker, plenary lecturer, Yusuf. M. Al-Hiari, ‘Novel heterocyclic carboxamide derivatives as potential antihyperlipidaemic Agents’ at 27th National and 15th International Chemistry Conference, organized by Department of Chemistry, University of Malakand, Pakistan , August 22-25 2016.

39- Invited and guest speaker, plenary lecturer, Yusuf. M. Al-Hiari, ‘Novel heterocyclic carboxamide derivatives as potential antihyperlipidaemic Agents’ at The Third international conference on (Research to Applications & Markets,, organized by Maghreb-Alexander Von Humboldt Alumni, Tunis , RAM 16-18/9/2016.

Registered Patents

1- Yusuf M. Al-Hiari*, Ali M. Qaisi, Jalal A. Zahra, Mona R. Hassuneh and Mustafa M. El-Abadelah, [a]Fused Heterocyclic-Pyrido[2,3-f]Quinoxaline-2-Carboxylic Acid Derivatives and their Pyrido[3,2-g] Analoges, A Procces for their Preparation and their Potential Uses as Anticancer and Antibacterial Agents, Jordan Patent 2345, May 2006, (priority date 12/4/2005).

2- Ali M. Qaisi, Yusuf M. Al-Hiari*, Jalal A. Zahra, and Mustafa M. El-Abadelah, Pyrido[2,3-f]Quinoxalines-8-Carboxylic Acid Derivatives and their Isomeric Pyrido[2,3-g]Quinoxalines, A Process for their Preparation and their Use as Potential Antibacterial Compounds, Jordan Patent 2323, Feb 2006, (priority date 12/5/2005).

3- Ghassan F. Shattat, Tariq M. Al-Qirim, Moyad J. Shahwan, Yusuf M. Al-Hiari, Ghassan M. Abu Sheikha, N-substituted-1H-indole-2-carboxamide derivatives, a process for their preparation and their use as potential antihyperlipidaemic agents, JP 2519, 13/7/2010. priority number:Jordan Patent ا ع -2008-373 - (date 14/8/2008), file number 35204.

4- Yusuf M. Al-Hiari*, Ali M. Qaisi, Jalal A. Zahra, Mustafa M. El-Abadelah and Mona R. Hassuneh, Anticancer and Antibacterial Agents, GB UK Patent, GB 2442 951, 23Feb, 2011, University of Jordan. (Date of publication: 23. 4. 2008)

5- Tariq M. Al-Qirim, Ghassan F. Shattat, Kamal Sweidan, Ghassan M. Abu Sheikha, Yusuf M. Al-Hiari, BENZOFURAN- AND BENZOTHIOPHENE-2-CARBOXAMIDE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS POTENTIAL ANTIHYPERLIPIDAEMIC AGENTS, Jordan Patent 2588- 02/6/2011. (priority date 9/12/2009), JP 2588 approved 27-2-2011.

International Patents applications through Jordan University

1-Ali M. Qaisi, Yusuf M. Al-Hiari*, Jalal A. Zahra, and Mustafa M. El-Abadelah, Antibacterial Agents, European Patent Application; No. 06 252 509.2, University of Jordan, 12 May 2006, (priority date 12/5/2005). Published on Scifinder (EP 1 721 898 A1) and European patent office Nov. 2006. (registered 2012-2013).

Thesis Supervision and Examination:

- MSc Students Supervision / main supervisor:

- MSc thesis; Inas Al-Mazari, 2004 “Synthesis of Potentially Antibacterial Novel Fluoroquinolone Derivatives Prepared from Introducing New Appendages at C-7 Position of 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid”, The university of Jordan, defence date: 26/12/2005.

- MSc thesis; Rofeida Al-Zubi, 2007, “Preparation of potentially antibacterial novel 8-nitrofluoroquinolone derivatives”, The university of Jordan, defense date: 3/8/2008.

- MSc thesis; Maha Al-Remawi, 2009, “Preparation and antimicrobial evaluation of 7-anilino- 8-nitrofluoroquinolones”, The university of Jordan, defence date: 3/8/2010.

- MSc thesis; Imad Ahmed, 2009 “Convenient Synthesis and Bioproperties of Heterocycles [h]-Fused Onto 4-Oxoquinoline-3-Carboxylic Acid: Halogenated Tetrahydro-1H-quino[7,8-b] [1,4-]benzodiazepin-3-carboxylic Derivatives”, The university of Jordan, defence date: 6/12/2010.

- MSc thesis; Rania Al-Qarm, 2009, “Novel 5-Fluoroindole-2-carboxamide Derivatives As Potential Antihyperlipidaemic Compounds”, The university of Jordan, defence date: 30/11/2010.

- MSc thesis; Botheina Huseen, 2009, “Preparation and antihyperlipidemic properties of new benzothiophen-2-carboxamide derivatives ”, The university of Jordan, defence date: 18/7/2010.

- MSc thesis; Nada Jarrar, 2014, “Screening of Nicotinic acid analogues as potential carbonic anhydrase III inhibitors ”, The university of Jordan, defence date: 23/5/2014.

- MSc thesis; Haneen Khaled , 2015, “SCREENING AND SIZE EFFECT INVESTIGATION OF NICOTINIC ACID ANALOGUES AS POTENTIAL CARBONIC ANHYDRASE III INHIBITORS TO TREAT HYPERLIPIDEMIA ”, The university of Jordan, defence date: 5/8/2015.

- MSc thesis; Yousef Shukri Al Absi, Dec. 2017, “Anti-Pancreatic Lipase and Anti-Proliferative Activities of New Fluoroquinolones”, The university of Jordan, defence date: Dec. 2017.

- MSc Students Supervision / co- supervisor:

- MSc thesis; Rughia Atia, 2011-2012, “ The Effect of Triazoloquinolones on Male Fertility of Albino Rats” AL-albayt Beat University, defence date: 29/7/2012.

- MSc thesis; Omaymah Ghaleb Al-Jamal, 2011-2012, “Effect of newly prepared compound in induced diabetic and hyperlipidemic albino rats” AL-albayt University, defence date: 29/7/2012.

- PhD Supervision / main supervisor:

- PhD thesis; Lubna Al-Sweelmeen, 2010, “Synthesis and biological evaluation of novel H-Fused heterocycles derived from floruoquinlones: Diazepines and benzodiazepines ”, 2010-2011. defence date: 1/12/2011

- PhD thesis; Manal Al-Najdawee, 2010, “The discovery of novel heterocyclic-2-carboxamide derivatives and their potential dyslipidemic and antioxidant activity”, defence date: 4/8/2011.

- PhD thesis; Shereen Arabiyat, 2016, “Synthesis, Docking studies and evaluation of Novel Fluoroquinolnes and triazolofluoroquinolones as potential pancreatic lipase inhibitors and antiproliferative compounds”, defence date: 9/8/2016.

- PhD Supervision / co-supervisor:

- PhD thesis/co-supervisor; Jameela Dabas, 2010, “Phytochemical and pharmacological screening of wild Jordanian Papaver polytricum Boiss. et Kotschy and partial chemical modification of selected or isolated major compounds.”, 2010. Defence date: 5/1/2012

- PhD thesis; Rana Abo Farha/co-supervisor;, 2015, “Pharmacological Screening of Newly Synthesized Derivatives of Nicotinic Acid and Isonicotinic Acid as Potential Anti-hyperlipidemic, Antioxidant and Cytotoxic agents

”, defence date: 15/7/2015.

- PhD thesis/co-supervisor; Soha tolfah, 2016, “drug discovery and chromatographic optimization of new carbonic anhydrase III ligands”, defence date: 22/12/2016.

- Thesis Examiner/ The University of Jordan:

1- MSc thesis entitled: “ Synthesis of Acyclic Nucleoside Phosphonates Pro-Drugs with Potential Antiviral Activity ” By Rami Horani, 2002.

2- MSc thesis entitled: “ The Effect of Crude Extract of Licorice on The Pharmacokinetics of Ciprofloxacin in an Animal Models”By Naser Shreem, 2003.

3- MSc thesis entitled: “ Analytical Method Development and Validation for the Evaluation of the Degradation of the Experimental Compound (EXP152) Developed as a Potential Neuromuscular Blocker, in Plasma”By Hind Nabeel Taha, March 2004.

4- MSc thesis entitled: “ Screening of Some Common Medicinal Plants of Jordan for Alpha Amylase Inhibition Activity,”By Tark Maayeh, July 2005.

5- MSc thesis entitled: “ Investigation of Diclofinac-Bismuth complex as an Oral Suspension Preparation” By Mohamad abu Znaid, Aug. 2005.

6- MSc thesis entitled: “Synthesis of Potentially Antibacterial Novel Fluoroquinolone Derivatives Prepared from Introducing New Appendages at C-7 Position of 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid”, By Inas Saleh, Dec. 2005.7- MSc thesis entitled: “ Development of a Flow Injection Method for the Determination of 5-Aminosalicy;ic Acid in Pharmaceutical Raw Material and Tablet Dosage Form” By Moutasim Eid AbuAl Ruz, Jan. 2006.8- MSc thesis entitled: “ Preparation and Characterization of Organic Salts of Valproic Acid, A Preformulation Study” By Mohammad Khanfer, 13th May 2007.9- MSc thesis , By Saja Awad , 16th May 2007.

10- MSc thesis; Rofeida Al-Zubi, “Preparation of potentially antibacterial novel 8-nitrofluoroquinolone derivatives”, 3/8/2008. 11- PhD Thesis, by Sana Ayash, Faculty of agriculture, Jordan Univ. 2008.

11- MSc thesis; Reem Jamal Awwad, “Evaluation of the wound healing activity of hexane extract of Alkanna Strigosa in albino rat model”, May 2009.

13- MSc thesis, By Eman Yousuf Ali Abu-Rish, “Comparative study of the bilogical potency of Two recombinant human Erythropoiten pharmaceutical producs in jordan”, Faculty of pharmacy, July 2009.14- PhD Thesis, by Reema A. Abu Khalaf, '' Discovery of new cholesteryl ester transfer protein (CTEP) inhibitors via ligand-based pharmacophore modeling and QSAR analysis and subsequent hit optimization'' Faculty of pharmacy, Aug 200915- PhD Thesis, by Afaf H. Al-Nadaf, '' Discovery and optimization of new beta secatase inhibitors as possible treatment for Alzhimer 's disease '' Faculty of pharmacy, Jan, 2010.16- MSc thesis, By Needa Zalloum, “Screening and evaluation of available hypoglycemic agents for their potential protective and treating effects of Diabetic Retinopathy”, Faculty of pharmacy, May 5, 2010.

17- MSc thesis by Maha Al-Remawi, “Preparation and antimicrobial evaluation of 7-anilino- 8-nitrofluoroquinolones”, August 3 2010.

18- MSc thesis by Botheina Huseen, “Preparation and antihyperlipidemic properties of new benzothiophen-2-

carboxamide derivatives ”, July 18 2010.

19- MSc thesis; Rania Al-Qarm, “Novel 5-Fluoroindole-2-carboxamide Derivatives As Potential Antihyperlipidaemic Compounds”, November 30 2010.

20- MSc thesis; Imad Ahmed, “Convenient Synthesis and Bioproperties of Heterocycles [h]-Fused Onto 4-Oxoquinoline-3-Carboxylic Acid: Halogenated Tetrahydro-1H-quino[7,8-b] [1,4-]benzodiazepin-3-carboxylic Derivatives”, December 6 2010.

21-MSc thesis; Yahya Tabaza, “physical and chemical stability studies of different excepients on ciprofloxacin solid formula ”, 8 2013.

- MSc thesis; Nada Jarrar, “Screening of Nicotinic acid analogues as potentioal carbonic anhydrase III inhibitors ”, The university of Jordan, defence date: May 2014.

- External examiner; 1- The final and third year pharmacy students at Al-Fatih University- Tripoli-Libya, 2004 .

2- Msc Thesis: Pharmacological Evaluation of Aminoacetylenic Phthalamide Compounds as Anti-inflammatory Agents, By Jinan Ali Salih Al-qaisi, Feb 2009, Petra University, Jordan. 3- The final and third year pharmacy students at Al-Fatih University- Medicinal Chemistry I and II, Tripoli-Libya, may 2010 .4-MSc thesis; Ibrahim Hamdan, “ Synthesis and Biological Evaluation of DiSubstituted 1,3,4-oxadiazole Derivatives”, Jordan Universityof science and technology (JUST), 12 May 2011. 5-MSc thesis; Leena Ali Al-Hawash, “ Stability indicating HPLC method of Trandolapril in pharmaceutical formulation and bulk materials”, Al-Ahliyya Amman University, 2 July 2012. 6-MSc thesis; Eyad Dawud, “ Simultaneous HPLC Determination of ACF inhibitors in Pharmaceutica Formulation, , Al-Ahliyya Amman University, 4 April 2013.

7-MSc thesis; Amani Omarin“ Assay and Stability indicating HPLC method of Tadalafil in pharmaceutical formulation and bulk materials by HPLC”, Al-Ahliyya Amman University, 26th Sep. 2013.8- MSc thesis; Munia Sowaileh“ Design and Synthesis of N-substituted Aminobenzamide Derivatives Targeting Dipeptidyl Peptidase-IV enzyme”, Jordan University of Science and Technology, July. 2013.8- MSc thesis : Bayan Hishmah; “ Design, Synthesis and Biological Evaluation of Novel PI3K alpha Inhibitors ”, Al-Zaytoonah University of Jordan, Dec., 2014.9- MSc thesis : Hamada Abd El-Aziz; “Synthesis and biological Evaluation of Flurinated alkyloxy Benzylamino B