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CURRICULUM VITAE

Chandra K. Mittal, B.S., M.S., Ph.D., FCPProfessor, Scientist, Columnist (Cell Phone: 713-398-6175)Office E-Mail: Chandra.Mittal@hccs.eduPersonal E-Mail: drckmittal@yahoo.com

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EDUCATION:

B.S., Biology/Chem/Geology (1967) First Class, Univ. of Lucknow, IndiaM.S., Biochemistry (1969) First Class, Univ. of Lucknow, IndiaPh.D., Pharmacology (1974) All-India Institute of Medical Sciences, New Delhi, Postdoc, Clinical Pharmacology (1974-1977) Univ. of Virginia Med. Center, Charlottesville, Va Elected Fellow (1987) American College of Clinical Pharmacology (FCP)Certificate in Distance Education (2017) Canvas-Eagle Online LMSCredentialed to Teach Biology, Biotechnology, Anatomy &

Physiology, Pharmacology, Pathophysiology

SIGNIFICANT SCIENTIFIC CONTRIBUTIONS:

1998 Nobel Prize in Medicine or Physiology: Co-Discover and Lead author of Nitric Oxide-Cyclic GMP Signaling system in collaboration with Dr. Ferid Murad who was awarded the 1998 Nobel Prize in Medicine for this discovery.

Nitric Oxide-Cyclic GMP System has Diagnostic, Therapeutic and Nutritional implications in Cardio-vascular health, sexual health, erectile dysfunction, etc.

PROFESSIONAL APPOINTMENTS:

2015- Professor of Biological & Bio-Medical Sciences - HCC2002-2015 Professor of Biotechnology – HCC-NE2011-2013 Biotechnology Program Coordinator – HCC-NE2003-2011 Associate Chair of Biology – HCC-NE1996-Present Founder & Scientific Director, Herichson Biotech, Inc. Texas, USA1992-1995 Research Professor (Pharmacology), TSU College of Pharmacy, Houston, Texas, USA1992 Supervisor, Division of Immunodiagnostics, NHL (now LabCorp) Houston, USA 1991-1992 Drug Discovery Consultant, Abbott Laboratories, Inc., USA1987-1991 Director - Biomedical Research, Escorts Heart Institute, New Delhi, 1980-1987 Assistant Professor of Pharmacology, Univ. IL Coll. Med., Peoria, Illinois, USA1977-1980 Instructor in Pharmacology, Univ. Virginia Sch. Med. Charlottesville, Virginia, USA1974-1977 Research Associate in Pharmacology, Univ. Virginia Sch. Med. Charlottesville, Virginia,

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AWARDS & HONORS: Editor, Global Vaccine & Vaccination Journal (2016 – Present)Member, Advisory Board – Healthline Magazine, Voice of Asia Group Publication, Houston (2016-Present)Editor, Journal of Microbiology & Experimentation (2014 – Present)Special Recognition Award, (1999): ASIOA, USA - for contribution to 1998 Nobel-Prize in Medicine (1998) Dr. & Mrs. G. P. Talwar Oration Award (2007), Association of Clinical Biochemists of IndiaExcellence Award, 2005, National Institute for Staff & Organizational Development (NISOD), USAMember (ad hoc) – NIH, Cardiovascular IRG, Hypertension & Microcirculation Study Section (2004-Present)Member (ad hoc)–National Science Foundation, Adv Tech Education Review GroupExpert Consultant – National Institutes of Health-RCMI Review Panel (1994), Elected Fellow, American College of Clinical Pharmacology, USA (1987) Manuscript Reviewer - BBA, Life Sci., JMCC, etc (1977-1996)Research Grant Reviewer, Am. Heart Assoc. (1981-1986)Research Fellowship, Govt. of India, (1969-1974)Merit Bursary Scholarship, University of Lucknow, India (1966-1967)Undergraduate Meritorious Student Stipend, Govt. of U.P. India (1965-66) High School Merit Scholarship, Govt. of U.P. India (1961-1963)

ADMINISTRATIVE ASSIGNMENTS: Biotechnology Program Coordinator, HCC (2011-2013)Associate Chair, Department of Biotechnology, Houston Community College System (2003-2007) Director of Research & Training, Escorts Heart Res. Institute, India (1987-1991)Ex-Officio Member – Biotechnology Advisory Board – HCC (2002 – Present) Member, Institutional Policy & Procedures Committee-HCC 2013)Member, Institutional Policy & Procedures Committee – HCC (2011) Member, Process Technology Faculty Search Committee – HCC (2012)Member, Petroleum Engineering Technology Faculty Search Committee-HCC 2012) Chair, Instrumentation Technology Faculty Selection Committee, HCC (2005)Member, Committee on International Programs, Houston Community College System (2002-Present) Member, Committee on Ph.D. Curriculum Development, Texas Southern Univ. (1994)Member, Scientific Advisory Board, Escorts Heart Res. Institute, New Delhi, India (1987-1991) Chairman, Executive Committee, Dept. Biomed. Sci, Univ ILL. Coll. Med. (1980-1985) Chairman, Committee of Research, University of Illinois. Coll. Med. (1980-87)Member, Committee on Pharmacology Curriculum, Univ ILL. Coll. Med. (1983-1985) Member, Committee on Student Appraisal, Univ ILL. Coll. Med. (1985 – 1987) Member, Committee on Grad. Med. Edu., Univ IL. Coll. Med. (1981- 1982)

ADVISOR / CONSULTANT: Ortho Pharmaceuticals, Inc. Raritan, New Jersey (1984) Abbott Laboratories, Inc. Abbott Park, Illinois (1989-1992) LifeCell Corporation, The Woodlands, Texas (1990)Aronex Pharmaceuticals, Inc., The Woodlands, Texas (1999)Neogenis Labs, Inc. Austin, Texas, USA (2013-Present)

COMMUNITY SERVICES Co-Founder, Indo-American Association, Houston, TX, USA (1993)President, Indian Association of Peoria, Peoria, Illinois, USA (1983)Founding Member, Society of Young Scientists, AIIMS, New Delhi, India (1973)Co-Founder & President, Naveen Tarun Sangh, Lucknow, India (1968-69)

MEDIA FEATURES 1. Indian J. Pharmacology 30: 347-350 (1998)

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2. Lancet, October, 19983. Express Pharma Pulse, December 10, 19985. Times of India, October 28, 19988. Deccan Herald, October 22, 19989. The Telegraph, October 25, 199810. The Economics Times, January 10, 199911. Times of India, January 24, 199912. Hindustan (Hindi), March, 2000

MEDIA INTERVIEWS 1. IGNOU-TV, Nobel Prize winning Discovery of Nitric Oxide, 19992. Invention Intelligence, March-April, 19993. Biospectrum, May, 2005 (pp, 18-19): Academic and workforce track are two models of biotech education in US.4. Biospectrum India, September, 2006 (pp, 22-24): The potential for biotechnology business in India.

PROFESSIONAL EXPERIENCE

Teaching Experience in Health Sciences :

All-India Institute of Medical Sciences. B.S. Med Tech Prog 5 years (1969-1974)

University of Virginia Sch. Med. M.D. & Nursing Prog 3 years (1977-1980)

University of Illinois Coll. Med. M.D Program 7 years (1980-1987)

University of Illinois Coll. Med Graduate Med. Ed 7 years (1980-1987)

Texas Southern Univ. Coll. PharmHouston Community College

Pharm.D

Biotech/Med.Sci

3 years

15 years

(1992-1995)

(2002-Present)

Scholarly Leadership : I have had a successful career in academia as demonstrated by research publications in the peer- reviewed national and international journals; supervision of research students, post-docs, technicians, fellows. I have won many meritorious scholarships, and received national and international honors and recognitions for my leadership in research and management capabilities, including the 2005 Excellence Awards from the National Institute for Staff & Organizational Development (NISOD). My original research work with discovery of Nitric Oxide-Cyclic GMP Signaling conducted at the University of Virginia was recognized by the 1998 Nobel Prize in Medicine or Physiology.

Higher Education Administration : Participated in administrative functions at universities, medical institutions, and Government Panels. Served as Chairman and Member of various institutional committees as listed above. As Associate Chair of Biotech program, developed Program Student Learning Outcomes (PSLOs) and Student Learning Outcomes (SLOs) and set criteria for program evaluations. Created new courses for HCC’s biotechnology program.These included Principles of Biochemistry (BITC-1403), Medical Biotechnology (BITC-2445), Immunological Techniques (BITC-2472) for AAS degree. These courses have been now adopted by the Texas Higher Education Coordinating Board in its Workforce Education Curriculum Manual (WECM). As Coordinator of HCC’s Biotechnology Program, carried out 5-yearly Program Review of Biotechnology Program in 2012, and made recommendation to strengthen Biotech program at HCC.

Developed new curricula and course descriptions for Advanced Technical Certificates (ATCs) in Clinical Research Technology involving drug trials, Biomedical Research Technology and Clinical Molecular Diagnostics for HCC Coleman College of Health Sciences. These skills are in high demand at the Texas Medical Center (TMC) institutions and other

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healthcare industry with large employment opportunities.

Clinical Diagnostics Services Administration : For 1987 to 1992, served as Director of Clinical Laboratories at the Escorts Heart Institute, New Delhi, and was responsible for designing and establishing the patient service labs, recruitment of medical technologists, procurement of equipment and materials, developing Standard Operating Procedures (SOPs), Quality Control guideline as per Good Laboratory Practices (GLP), and creating complete documentation systems. The service laboratories earned recognition from European International Standard Organization (ISO)

Worked as Manager/Supervisor of Immunodiagnostics division at the National Health Laboratories, Inc. (Presently called LabCorps) at Houston. Supervised 9 medical lab technologists conducting 2000 clinical tests daily. Managed laboratory operations and certified QC and reported clinical reports to physicians.

Medical Research Administration : As Director of Research at Escorts Heart Institute, New Delhi prepared institutional research reports for Govt. approval, organized and directed an epidemiological study in collaboration with University of Texas Medical Branch, Galveston (UTMB) on the incidence of coronary artery disease (CAD) among Asian-Indians. Created a comprehensive cardiac check-up (CCC) and generated an omnibus data base on the ST-segment analysis during exercise-EKG, physical exam, lipid, profile, family history, dietary inputs, and the incidence of CAD. Comparisons were made between the CAD patterns between Asian-Indians and their Caucasian counterparts. The screening program resulted in detection of high level of CAD detection among Asian-Indians at a younger age.

Medical Diagnostics Business Management : Founded, Directed & Managed as CEO for 7 years a Medical Product business (Herichson Biotech, Inc.) in In Vitro Diagnostic (IVD) biotechnology in the United States. The products included Coagulation products, Clinical Biochemistry reagents & ELISA products for the diagnosis of endocrine disorders, cardiovascular disease, cancer and infectious diseases. Worked independently as well as in alliance with other corporate bodies, managed all aspects of business operations including compliance with US-FDA regulations, & product registration with Govt. of India. Established a bio-manufacturing facility as per cGMP guidelines to produce In Vitro Diagnostic (IVDs) devices in Houston. Created marketing infrastructure in India for product distribution and customer support, recruited personnel for business processing, marketing, sales, and technical support.

Clinical Research Services : Organized and created working infrastructure to conduct clinical trials on new therapeutic entities (NTEs).Clients included Aronex Pharmaceuticals, Inc. USA and Pharm-Olam International, a Houston-based CRO, for anti-fungal drug trials on AIDS patients. Identified clinical trial Sites with suitable patient population, recruited qualified physician investigators, and organized logistics for Government regulatory compliance. Fully aware and experienced with Institutional Review Board (IRB) for patient safety issues and Informed Consent in Clinical Trials.

Government & Foundation Panels : I serve on the Expert Panels of the National Institutes of Health (Cardiovascular Sciences) and National Science Foundation (NSF), both Federal government agency, for the scientific review and recommendations on the allocation of resources for research investigators and institutions. Previously, I also served on special National Panel for Site Visit to Charles Drew Medical School, Los Angeles, CA for review of a $ 5.0 Million grant for institutional development. I have also served on the Expert Panel of the American Heart Association.

Minority Disease Research : At the Texas Southern University (1992-1995) conducted NIH-RCMI (Research Centers in Minority Institutions) funded research projects on Hypertension in African-American population. The disproportionately higher incidence of the disease was investigated at molecular levels in animal models. Received federal grants from NIH- MBRS (Minority Biomedical Research Support), and trained students and scientists belonging to the minority community. I have supervised research presentations by African-American students at the national scientific meetings.

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Scientific Editorial Panels : Have served on editorial boards of national and international medical and biomedical journals to review scientific research manuscripts. Have also written Research Review articles, monographs, research reports and commentaries.

Journalistic Endeavors : Write essays, Op-Eds and analytical columns in newspapers, magazines on current national and international affairs related with political developments, governance and religion. These are listed in resume .

MEDICAL RESEARCH GRANTS:

1. “Vascular signal transduction in hypertension”Principal Investigator : Chandra K. Mittal, Ph.D, National Institutes of Health, $ 287,424 (9/94 – 8/98)

2. “Actions of atriopeptin (ANP) on vascular smooth muscle in hypertension”Principal Investigator : Chandra K. Mittal, Ph.D., Am. Heart Assoc., $ 30,000 (7/85 – 6/87)

3. “Regulation of myocardial cyclic GMP synthesis”Principal Investigator : Chandra K. Mittal, Ph.D., Am. Heart Assoc., $ 30,000 (7/81 – 6/83)

4. “Cholinergic modulation of myocardial cyclic GMP”Principal Investigator : Chandra K. Mittal, Ph.D., Univ. IL Res. Board, $ 10,000 (7/81 – 8/82)

5. “Cyclic nucleotide metabolism during senescence”Principal Investigator : Chandra K. Mittal, Ph.D., NIH 80417 (6/80 – 8/81)

6. “Pharmacological modulation of cyclic GMP metabolism”Principal Investigator : Chandra K. Mittal, Ph.D., Am. Heart Assoc. $ $ 16,000 (7/78 – 12/79)

7. “Mechanism of physiological modulation of cyclic GMP synthesis”Principal Investigator : Chandra K. Mittal, Ph.D., Pharmaceutical Manufacturers Association Foundation. $ 16,000 (1/78 – 12/79)

MEDICAL RESEARCH SUPERVISION

John Heimanz, B.S. Medical Research Fellow (1975)Robert Aldred, B.S. Research Assistant (1975-78)Kikuo Ichihara, M.D. Research Associate (1977-78)Mahmoud El-Zayat, Ph.D UNESCO Fellow (1977-78)William P. Arnold, M.D. Clinical Fellow (1977-78)J.Mark Braughler, Ph.D Postdoctoral Fellow (1977-78)Akihiko Wada, M.D. Research Associate (1978-80)Julia Ruffin, B.S. Research Assistant (1978-80)

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Rose Duffield, M.S. Research Technologist (1980-87)Mohammad Gabr, B.S. Research Assistant (1981-83)John Groch, B.S. Medical Research Fellow (1983)Sharon Murnan, M.S. Research Technologist (1983-84)Jeff Hallet, B.S. Medical Research Fellow (1984)Valerie Grondin, M.S. Research Specialist (1985-86)Anuradha Sureka, M.D. Research Fellow (1985-86)Mark Richman, B.S. Research Scientist (1988-91)Shelley Verma, M.A. Research Assistant (1987-90)Arun Raizada, M.S. Research Biochemist (1987-91)S. K. Jha, M.S. Research Assistant (1988-91)Rita Singhal, Ph.D. Research Fellow (1994-95) Andrew O Anugwom, B.Pham. Research Assistant (1994-95) Igeoma ‘Robin’ Okpara Research Assistant (1994-95)James George, B.S. Research Assistant (1995)

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INVITED SCIENTIFIC LECTURES

1. All-India Institute of Medical Sciences, New Delhi, India (1976)2. Smith Kline & French Laboratories. USA (1979)3. Medical College of Virginia, Richmond, VA (1979)4. Indiana University School of Medicine, Evansville, IN (1979)5. University of Illinois College of Medicine, Peoria, IL (1979)6. All-India Institute of Medical Sciences, New Delhi, India (1982)7. Patel Chest Institute, University of Delhi, Delhi, India (1982)8. Ciba-Geigy Pharmaceuticals, Summit, N.J (1882)9. R.W.Johnson Institute, N.J. Raritan, N.J. (1983)10. Texas Tech University School of Medicine, Lubbock, Texas (1984)11. Hoffmann La Roche Pharmaceuticals, Nutley, N.J. (1984)12. Central Drug Research Institute, Lucknow, India (1985)13. Indian Institute of Technology, New Delhi, India (1985)14. Jawaharlal Nehru University, New Delhi, India (1986)15. University of Illinois College of Medicine, Chicago, IL. (1986)16. Indian Toxicology Research Center, Lucknow, India (1986)17. Mahatma Gandhi Medical College, Indore, India (1987)18. Central Drug Research Institute, Lucknow, India (1988)19. Defense Institute of Physiology & Allied Sciences, Delhi, India (1989)20. University of Houston College of Pharmacy, Houston, TX (1990)21. Baylor College of Medicine, Houston, TX (1990)22. Henry Ford Heart Research Institute, Detroit, MI (1991)23. Texas Southern University, Houston, TX (1992)24. University of Puerto Rico, San Juan, Puerto Rico (1995)25. Ministry of Science & Technology, Govt. of India, Delhi (1998)26. Hamdard University, Delhi, India (1998)27. All-India Institute of Medical Sciences, New Delhi, India (1999)28. Torrent Pharmaceuticals, Ahmedabad, India (1999)29. Dr. Reddy Research Foundation, Hyderabad, India (1999)30. Indian Oil Corporation Research Center, Faridabad, India (1999)31. India Medical Association, Roorkee Chapter, Roorkee, India (2000)32. University College of Medical Sciences, Delhi, India (1999)33. Malhotra Heart Institute, New Delhi, India (2000)34. Department of Biochemistry, University of Lucknow, Lucknow, India (2001)35. Dept. of Biotechnology, AIIMS, New Delhi, India (2001)36. King George Medical University, Lucknow, India (2003)37. Biophex 2004, San Francisco, CA (2004)38. International Conference on Drug Development, AIIMS, Feb 200739. Amity Institute of Biotechnology, Amity University, NOIDA, India, May, 200740. Dr. & Mrs. G. P. Talwar Oration Award, Association of Clinical Biochemists of India (2007)41. Apeejay Institute of Management, New Delhi, India (2008)42. Sharda University, Greater Noida, India (2009)43. Apeejay Institute of Management, New Delhi, Ind a(2009)44. Sharda University Research Development & Technology Center, Greater Noida, India (2010)45. Amity Institute of Microbial Technology, Amity University, NOIDA, India, August, 2012

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SCIENTIFIC PUBLICATIONS

Peer-Reviewed Articles:

1. Mittal, CK: Studies on adenylate cyclase and cyclic AMP phosphodiesterase in chick brain. Ph.D. Thesis, All-India Institute of Medical Sciences, New Delhi, India (1974)

2. Kimura,H., Mittal, CK and Murad, F: Activation of guanylate cyclase from rat liver and other tissues by sodium azide. J. Biol. Chem. 250, 8016-8022 (1975)

3. Mittal, CK., Kimura, H and Murad, F: Requirement of a macromolecular factor for sodium azide activation of guanylate cyclase. J. Cyclic Nucl.Res. 1, 261-269 (1975)

4. Kimura, H., Mittal, CK and Murad, F: Increases in cyclic GMP levels in brain and liver with sodium azide - an activator of guanylate cyclase. Nature 257, 700-702 (1975)

5. Kimura, H., Mittal, CK and Murad, F: Appearance of magnesium guanylate cyclase activity after sodium azide activation. J. Biol. Chem. 251, 7769-7773 (1976)

6. Mittal, CK and Murad, F: Formation of adenosine 3’,5’-monophosphate by preparations of guanylate cyclase from rat liver and other tissues. J. Biol. Chem. 252, 3136-3140 (1977)

7. Mittal, CK, Kimura, H, and Murad, F: Purification and properties of a protein factor required for sodium azide activation of guanylate cyclase. J. Biol. Chem. 252, 4384-4390 (1977)

8. Murad, F., Kimura, H., Mittal, CK and Arnold, WP: Guanylate cyclase - Properties and regulation. Endocrinology V Int. Cong. Vol I, 507-511 (1977)

9. Katsuki, S., Arnold, WP Mittal, CK and Murad, F: Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerine and nitric oxide in various tissues and comparison to effects of sodium azidse and hydroxylamine. J. Cyclic Nucl. Res. 3, 23-35 (1977)

10. Mittal, CK and Murad, F: Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical - a physiological regulator of guanosine 3’,5’-monophosphate formation. Proc. Nat. Acad. Sci,US 74, 4360- 4364 (1977)

11. Mittal, CK and Murad, F: Properties and oxidative regulation of guanylate cyclase. J. Cyclic Nucl. Res. 3, 381-391 (1977)

12. Arnold, WP., Mittal, CK., Katsuki, S and Murad, F: Nitric oxide activates guanylate cyclase and increases cyclic GMP levels in various tissues. Proc. Nat. Acad. Sci, US 74, 3203-3207 (1977)

13. Katsuki, S., Arnold, WP., Mittal, CK and Murad, F: Stimulation of formation and accumulationof cyclic GMP by smooth muscle relaxants. Proc. 2nd Cyclic Nucleotide Conference, Japan. Pp 45-51 (1977)

14. Mittal, CK. Arnold, WP and Murad, F: Characterization of protein inhibitors of guanylate cyclase activation from rat heart heart and bovine lung. J. Biol. Chem. 253, 1266-1271 (1978)

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15. Mittal, CK and Murad, F: Formation of cyclic AMP by guanylate cyclase after activation with azide, nitro- and nitroso-compounds. Adv. Cyclic Nucle. Res. 9, 742, (1978)

16. Muard, F., Mittal, CK., Arnold, WP., Katsuki, S., and Kimura, H: Guanylate Cyclase: Activation by azide, nitro compound, nitric oxide and hydroxyl radical and inhibition by hemoglobin and myoglobin. Adv. Cyclic Nucl. Res. 9, 145-158 (1978)

17. Murad, F., Mittal, CK., Arnold, WP., Ichihara, K., and Braughler, JM: Properties and regulation of guanylate cyclase: Activation by azide, nitro-compounds and hydroxyl radical and effect of heme containing proteins. Mol. Biol & Pharmacol. (Cyclic Nucleotides) pp. 33-42 (1978), Elsevier Press.

18. Mittal, CK., Braughler, JM., Ichihara, K and Murad, F: Synthesis of adenosine 3’,5’-monophosphate by guanylate cyclase: A new pathway for its synthesis. Biochim. Biophys. Acta. 585, 333-342 (1979)

19. Braughler, JM., Mittal, CK and Murad, F: Purification of soluble guanylate cyclase from rat liver. Proc. Nat. Acad. Sci, US 76, 219-222 (1979)

20. Ichihara, K., El-Zayat., Mittal, CK and Murad, F: Fatty acid activation of guanylate cyclase from fibroblast and rat liver. Arch. Biochem. Biophys. 197, 44-51 (1979)

21. Murad, F., Arnold, WP., Mittal, CK and Braughler, JM: Properties and regulation and role of guanylate cyclase and cyclic GMP. Adv. Cyclic Nucle. Res. 11, 175-204 (1979)

22. Murad, F., Mittal, CK., Arnold, WP and Braughler, JM: Effect of nitro-compounds, smooth muscle relaxats and other materials on cyclic GMP metabolism. Adv. Pharmacol. Therp. 3, 123-132 (1978)

23. Braughler, JM., Mittal, CK and Murad, F: Effect of thiols, sugars and proteins on nitric oxide on activation of guanylate cyclase. J. Biol. Chem. 254, 12450-12454 (1979)

24. Murad, F., Lewicki, JA., Brandwein, HJ., Mittal, CK and Waldman, SA: Guanylate cyclase: Guanylate cyclase: Purification, properties, free-radical activation, radiolabeling and preparation of hybridoma monoclonal antibodies. Adv. Cyclic Nucl. Res. 14, 229-240 (1981)

25. Mittal, CK and Murad, F: Guanylate cyclase: Regulation of Cyclic GMP metabolism. Handbook Exptl. Pharmacol. 58/I, 225-260 (1982)

26. Lewicki, JA., Brandwein, HJ., Mittal, CK and Murad, F: Properties of purified soluble guanylate cyclase by nitric oxide and sodium nitroprusside. J. Cyclic Nucle. Res. 8, 17-25 (1982)

27. Mittal, CK: Phospholipase A2 modulation of cyclic GMP metabolism: Activation of guanylate cyclase. Int. J. Biochem. Biophys. 21, 44-46, (1984)

28. Mittal, CK: Cholinergic-muscarinic receptors in myocardium: Properties of (3-H) quinuclidinyl benzilate binding. Int. J. Exptl. Biol. 23, 300-305 (1985)

29. Mittal, CK: Phospholipase A2-modulation of cyclic GMP metabolism: Characteristics of guanylate cyclase activation. Life Sci. 37, 2143-2149 (1985)

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30. Mittal, CK: Molecular interaction of vasodilators: Modulation of cyclic GMP by nitro-drugs and atrial natriuretic factor (ANF). Ind. J. Heart Res. 2, 21 (1985)

31. Mittal, CK: Atriopeptin II and nitrovasodilator-mediated shifts in cyclic GMP in rat thoracic aorta: Evidence for involvement of distinct guanylate cyclase pools. Eup. J. Pharmacol. 115, 127-128 (1985)

32. Mittal, CK: Science in India. Nature, 311, 8 (1984)

33. Mittal, CK: Determination of guanylate cyclase and adenylate cyclase activities in cells of immune system. Methods in Enzymol. 132, 422-428 (1986)

34. Mittal, CK: Measurement of cyclic AMP and cyclic GMP levels in polymorphonuclear leukocytes, macrophages and lymphocytes. Methods in Enzymol. 132, 428-434 (1986)

35. Mittal, CK, Actions of atrial natriuretic peptides on cyclic GMP system in vascular smooth muscle. Int. J. Exptl. Biol. 25, 24-28 (1987)

36. Mittal, CK: Interaction of atrial natriuretic peptides in hypertension. Ind. J. Physiol. Pharmacol. 31, 5-6 (1987)

37. Mittal, CK: Management of Science in India. Times of India (Feature), May (1988)

38. Mittal, CK: Membrane receptors for catecholamines and atrial peptides in hypertension. Proc Int. Symp. Biomemb. Dis. (1989), Raven Press, N.Y

39. Mittal, CK and Jadhav, AL: Renal atrial natriuretic peptide (ANP receptors during sodium-loading. Clin. Pharmacol. Therap. 53, 234 (1993)

40. Mittal, CK: Nitric oxide synthase: Involvement of oxygen-radicals in conversion of L-arginine to nitric oxide. Biochem. Biophys. Res. Commun. 193, 126-132 (1993)

41. Mittal, CK: Decrease atrial peptide receptors in adrenal gland in spontaneously hypertensive rats (SHR) Am. J. Hyperten. 6, 431-433 (1993)

42. Dayal. HH., Ui-hwei Li., Dayal, V., Mittal, CK and Snodgrass, W. On utility of medication data in community- based symptoms prevalence studies. Arch. Environ. Health 49, 93-97 (1993)

43. Mittal, CK: Characterization of L-arginine effect on cyclic GMP system in neuroblastoma cells. Proc. Texas Acad. Sci. p. 35, (1994)

44. Mittal, CK and Jadhav, AL: Calcium-dependent inhibition of constitutive nitric oxide synthase. Biochem. Biophys. Res. Commun. 203, 8-15 (1994)

45. Mittal, CK and Jadhav, AL: Calcium-dependent regulation of brain constitutive NO synthase: Mechanism of NO generation and its dual control by calcium ion. Proc. Int. Conf. Biochem. Mol. Biol. Nitric Oxide, p. 71 (1994)

46. Mittal, CK: Oxygen-radicals/nitric oxide mediate calcium-dependent actions of hormones on cyclic GMP system: A novel concept in signal transduction. Mol. Cell. Biochem. 149, 257-262 (1995)

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47. Mittal, CK., Houston, DE., Harrell, WB and Mehta, CS: Interaction of heavy metal toxicants with brain nitric oxide synthase. Mol. Cell. Biochem. 149, 263-265 (1995)

48. Mittal, CK and Mehta, CS: Regulation of nitric oxide synthase: Role of oxygen-radicals and cations in nitric oxide formation. Adv. in Pharmacol. 34, 235-250 (1995)

49. Mittal, CK: NO synthase-independent conversion of L-arginine to L-citrulline: A potential source of error in NOS activity determination. FASEB J. 9, 681 (1995)

50. Anugwom, AO., Singhal, R and Mittal, CK: Reversal of NO-activated guanylate cyclase by hemoglobin and methylene blue. FASEB. J 9, 676 (1995)

51. Mittal, CK: Nitric oxide and oxygen-radicals in signal transduction mechanisms- Implication in cardiovascular disorders. Proc. Current Trends in Cardiovas. Res., San Juan, Puerto Rico (1995)

52. Mittal, CK., Mittal, R and Galiotos, J.A: Nitric Oxide: Regulation and Clinical Relevance. Trends in Clinical Biochem, pp 577-580 (2003), Assoc. Clin. Biochem. India

53. Mittal, CK: Oxygen-Radicals as Bio-Regulators: A Novel Concept in Physiology, Proc. Am. Assoc. Physicians of Indian Origin, December 22-23, (2003)

54. Mittal, CK: Anatomy of Discovery of Nitric Oxide-Cyclic GMP Signaling System: A Novel Platform for New Drugs & Diagnostics. Indian J. Clin. Biochem, 22, 19-20 (2007)

55. Mittal, CK: Physiological Regulation by Oxygen-Radicals (in preparation)

56. Mittal, CK and Raizada, A: Molecular Pathology of Hypertension. (Invited, in preparation)

57. Richa Chandra, Birgit Mellis, Kyana Garza, Samee A. Hameed a, James M. Jurica, Ana V. Hernandez,Mia N. Nguyen, Mittal, CK: Remnant lipoprotein size distribution profiling via dynamic lightscattering analysis. Clinica Chimica Acta 462, 6-14 (2016)

Abstracts:

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2. Mittal, CK and Sharma, SK: Adenylate cyclase in developing chick brain. Symp. Mol. Mech. Drug Act. CDRI, India (1970)

3. Mittal, CK and Sharma, SK: Ontogenetic development of adenylate cyclase. Proc. 40the Soc. Biol. Chem. India, 1971

4. Mittal, CK and Sharma, SK: Adenylate cyclase and cyclic AMP-phosphodiesterase in development. Proc. Int. Symp. Brain & Behav. India (1972)

5. Mittal, CK., Joshi, A and Sharma, SK: Adenylate cyclase in nerve cell bodies and glial cells from rat cerebral cortex. Proc. 41st Soc. Biol. Chem. India (1972)

6. Kimura, H., Mittal, CK and Murad, F: Activation of guanylate cyclase by sodium azide. Clin. Res. 23, 324 (1975)7. Kimura, H., Mittal, CK and Murad, F: Sodium azide activation of guanylate cyclase. Proc. VI Int. Cong. Pharmacol. P.

392 (1975)8. Mittal, CK., Kimura, H and Murad, F: Activation of guanylate cyclase by sodium azide. Gordon Conf. “Cyclic

Nucleotides” (1975)9. Kimura, H., Mittal, CK and Murad, F: Magnesium-dependent guanylate cyclase after sodium azide activation. Fed. Proc.

35, 434 (1976)10.Mittal, CK and Murad, F: Formation of cyclic AMP by guanylate cyclase preparation after activation with sodium azide.

Clin. Res. 25, 49 (1977)11.Mittal, CK., Kimura, H and Murad, F: Properties of a protein factor required for sodium azide activation of

guanylate cyclase. Fed. Proc. 36, 737 (1977)12.Katsuki, S., Arnold, WP., Mittal, CK and Murad, F: Stimulation of guanylate cyclase in various tissues by

nitroprusside, nitroglycerine, hydroxylamine and sodium azide. Clin. Res. 25, 58 (1977)13.Braughler, JM., Mittal, CK and Murad, F: Purification and properties of guanylate cyclase. Gordon Conf. “Cyclic

Nucleotides” (1978)14.Arnold, WP., Katsuki, S., Mittal, CK and Murad, F: Stimulation of guanylate cyclase by nitric oxide. Adv. Cyclic Nucle.

Res. 9, 743 (1978)15.Ichihara, K., El-Zayat, M., Mittal, CK and Murad, F: Activation of guanylate cyclase from fibroblast and liver by

fatty acids. Fed. Proc. 37, 390 (1978)16.Arnold, WP., Braughler, JM., Mittal, CK and Murad, F: Activation of guanylate cyclase by thiols. Fed, Proc. 37,

390 (1978)17. Mittal, CK and Murad, F: Effect of phospholipase A2 and lipoxigenase on guanylate cyclase. Fed. 37, 1689 (1978)

18. Mittal, CK and Murad, F: Cyclic AMP formation by guanylate cyclase. Clin. Res. 26, 531 (1978)19.Braughler, JM., Mittal, CK and Murad, F: Purification of soluble guanylate cyclase from rat liver to

apparent homogeneity. Clin. Res. 27, 788 (1979)20.Mittal, CK., Braughler, JM and Murad, F: Modulation of purified guanylate cyclase by proteins. Fed. Proc. 38,

318 (1979)21. Wada,A., Mittal, CK and Murad, F: Cyclic GMP levels and B-glucuronidase from human polymorphonuclear leukocytes.

Clin. Res. 28, 498 (1980)22. Mittal, CK: Guanylate cylcase: an alternate pathway for cyclic AMP formation. Proc. Asian & Oceanian Biochem (1981)23. Mittal, CK: Clonidine and prazosin receptors in neurogenic hypertension. Fed. Proc. 42, 647 (1983)24.Mittal, CK., Duffield, R and Luqman, GA: Nitrendipine, prazosin, clonidine and QNB binding in brain memebranes

from normotensive and hypertensive rats. Pharmacologist 25, 240 (1983)25.Mittal, CK: Age-dependent alterations in cholinergic-muscarinic receptors and cyclic GMP metabolism. Fed. Proc. 43,

624 (1984)26.Ho, A., Mittal, CK and Hjelle, JT: Subcellular distribution of calmodulin and guanylate cyclase in kidney

proximal tubules. Fed. Proc. 43, 766 (1984)27. Mittal, CK., Groch, JS and Kalyan-Raman, U: Guanylate cyclase and cholinergic receptors sites in human brain tumors.

Clin. Res. 32, 419 (1984)

13

28. Mittal, CK., Hallet, JF and Kalyan-Raman, K: Ca2+ modulation of RBC cyclic GMP in muscular dystrophy patients. Clin.

Res. 33, (1985)29.Mittal, CK and Duffield, R: Interaction of atriopeptine with thoracic aorta and renal membranes. Proc. Int. Heart Soc

(1986)30.Mittal, CK: Atriopeptin and phospholipase A2 dependent modulation of cyclic GMP-guanylate cyclase system.

Fed.Proc. 46, 192 (1986)31.Mittal, CK: Atrial natriuretic protein (ANP) receptor in vascular smooth muscle: Characterisitcs and

properties> Pharmacologist 28, 93 (1986)32.Mittal, CK: Effect of cations on atrial natriuretic protein (ANP) receptors in vascular smooth muscle . Fed. Proc.

47, (1987)33. Mittal, CK: Atrial natriuretic peptide (ANP) receptors in genetic hypertension. FASEB J. 6, (1992)34. Mittal, CK: Formation of nitric oxide by NO synthase requires oxygen-radicals. Pharmacologist 35, 162 (1993)

35. Mittal, CK and Jadhav, AL: Effect of cations on nitric oxide synthase. FASEB J. 8, 362 (1994)36.Mittal, CK: Oxygen-radicals and nitric oxide mediate hormonal regulation of cyclic GMP system. Proc. Int. Symp. Sec.

Messengers, Trinidad, June, 199437.Mittal, CK and Houston, D: Differential modulatory effects of heavy-metal toxicants on constitutive NO synthase

activity. The Toxicol. 15, 10 (1995)38. Mittal, CK and Mehta, CS: Nitric oxide synthase - A new target for envirnmental toxicants. Proc. Am. Chem. Soc. (1995)39. Mehta, CS and Mittal, CK: Role of cyclic GMP in the neurotoxicity of trimethyltin in rats. Int. Cong. Toxicol. P.12 (1995)40.Mittal, CK: Phospholipid-phospholipase A2 dependent activation of particulate guanylate cyclase. 9th Int. Conf. 2nd.

Messenger & Phosphoproteins (1995)41.Mittal, CK: Discovery of Nitric oxide signaling system: A novel concept in signal transduction. Ind. J. Pharmacol. Dec

199842.Mittal, CK: Nitric Oxide: Discovery & Importance in Cardiovascular Diseases. Proc. 9th Asian Pac. Congress Clin.

Biochem (2002)43.Mittal, CK and Galiotos, J.A: Biotechnology Education at Houston Community College. Am. Chem. Soc. (in press,

2003)44.Mittal, CK, Theresa L. Spain and Galiotos, J.K: “Development of Enzyme-Linked Immunosorbent Assay (ELISA) kit –

An Important biotechnological tool for medical diagnostics and therapeutics. Am. Chem. Soc. (2003)45.Mittal, CK and Galiotos, J.K: Biotechnology Education at Community Colleges-An Emerging Challenge. Am. Soc.

Biochem & Mol. Biol. (2003)46.Mittal, CK: Community Colleges as Business Incubators – A Novel Concept for Small Businesses in Biotechnology.

Biophex 2004 Conference, San Francisco, CA, September 28-30, 2004.47.Mittal, CK, Galiotos, JK and Hernandez, KJ: Structuring a Workforce Training Program for Global Biotechnology

Industry, FASEB J. 200548. Mittal, CK, Sen, P, Spain, T, Galiotos, G, and Hernandez, K: A Model Curriculum for Training in Molecular

Diagnostics. Proc. XIX International Clinical Chemistry (2005) & Am. Assoc. Clin. Chem (2005)

Newspaper Articles and Op-Ed Columns

1. Science in India. N a t u re, vol. 3 1 1 , p 8 ( 1 9 8 4 )

2. Management of Science in India. Ti m e s o f I n d ia ( M a y, 19 8 8 ) 3. Is Indian Prime Minister Narendra Modi, Ronald Reagan of India? Voice of Asia , Vol. 27, No 28 (2014)

4. Is Indian Prime Minister Narendra Modi, Ronald Reagan of India? India Tribune, Chicago, August 15, 2014

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5. Narendra Modi – A Transformative Leader for 21st Century India. India Tribune, Chicago , August 22, (2014) 6. Narendra Modi: Transformational Leader for 21st Century. India West, San Leandro, CA , Oct 31, (2014) 7. Indian Cultural Values versus American Democratic System. Voice of Asia, Houston , Vol. 27, No. 34 (2014) 8. Hinduism – A World Force for Peace, Tranquility and Happiness. Voice of Asia, Vol. 27, No. 42, (2014)

9. Dawn of a New Era in US-India Bilateral Relations. Voice of Asia, Houston, Vol. 27, No. 48, (2014) 10. India Needs District-Level Governing Autonomy for Prosperity and Stability - An Open Letter to Prime Minister

Narendra Modi. Voice of Asia, Houston, Vol. 27, No. 51 (2014)

11. India Needs District-Level Governing Autonomy for Prosperity and Stability - An Open Letter to Prime Minister Narendra Modi.. India New England, Waltham, MA (2014)

12. India Needs District-Level Governing Autonomy for Prosperity and Stability - An Open Letter to Prime Minister Narendra Modi. The South Asia Times, New York, p. 12, Dec 27th (2014)

13. India Needs District-Level Governing Autonomy for Prosperity and Stability - An Open Letter to Prime Minister Narendra Modi. NRI-Press, California (2014)

14. India’s Simultaneous Rendezvous with United States and Russia: New Economic Pragmatism in the changing World. Voice of Asia , Houston , Vol. 28, No 1 (2015)

15. India’s Simultaneous Rendezvous with United States and Russia: New Economic Pragmatism in the changing World. The South Asia Times, New York, Jan 17 th (2015)

16. A Historic Day, a Historic Event: Obama Visit to India. www. indiacurrents.com /articles/2015/01/27

17. American Philanthropy - A symbol of American Exceptionalism. VOICE OF ASIA Vol. 28, No. 18 p10, 2015

18. American Philanthropy - A symbol of American Exceptionalism. The South Asia Times, NY ( April 26, 2015)

19. Is Political Correctness Undermining American Civilization? Voice of Asia Vol. 28, No. 20, p2, 2015

20. Is Political Correctness Undermining American Civilization? India Tribune, Chicago, May 22, 2015

21. Economic Globalization versus National Sovereignty- New Challenges and Solutions in the Transforming World. Voice of Asia Vol. 28, No. 22, p2, May 29, 2015

22. Modi’s New India: A View from the Main Street. Voice of Asia , Vol. 28, No. 30, p2, 2015

23. Greece Debt Crisis – A Greek Tragedy without Catharsis. VOICE OF ASIA. Vol. 28, No. 31, p8, (2015)

24. Modern India Needs Presidential Form of Government: A Model for National Stability, Prosperity & Progress. VOICE

OF ASIA Vol. 28, No. 28, p2, 2015

25. Iranian Nuclear Agreement: An Exercise in Global Economic Pragmatism. Voice of Asia, Vol. 28, No. 33, p2, (2015), 26. Multi-Culturalism in America: An Asset or Liability for Society. Voice of Asia, Vol. 28, No. 36, p2, 2015,

27. Syrian Refugee Crisis is Failure of United Nations. Voice of Asia, Vol. 28, No. 39, p2, 2015

28. Mahatma Gandhi: An Apostle of Non-Violence. Voice of Asia, Vol. 28, No. 40, p10, 2015

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29. NARENDRA MODI: An Opportune Moment to Settle Indo-Pakistan Dispute. Voice of Asia, Vol. 28, No. 40, 2015

30. Opportune Time to Settle Indo-Pak Dispute. India West Oct 9, 2015

31. INCLUSIVE CAPITALISM: Panacea for Prosperity in Stagnant Economy. Voice of Asia, Vol. 28, No. 42, 2015

32. THE BENGHAZI BUNGLE: A High-Powered Political Deception. Voice of Asia, Vol. 28, No. 44, p2, 2015 ,

33. AMERICAN CONSTITUTION: The Holy Book for all American. Voice of Asia, Vol. 29, No. 1, p2, 2016

34. Over-Speculative US Capitalism: A Source of Public Discontent and Political Divide. Voice of Asia, Vol. 29, No. 12, p2, 2016

35. Demonizing American Muslims is Not American. INDIA-WEST, April 29, 2016

36. Demonizing American Muslims is Not American: An Indo-American Perspective. Voice of Asia, Vol. 29, No. 18, p2, 2016

37. Can Populism Alone Propel Donald Trump into US Presidency? Voice of Asia, Vol. 29, No. 19, p2, 2016

38. Orlando Tragedy Sadly Becoming Political Opportunism. Voice of Asia. Vol. 29, No. 26, p7, 2016

39. BREXIT – A Warning for all Industrialized Nations. Voice of Asia, Vol. 29, No. 27, p2, 2016

40. An Idea Called America - A Tribute to Independence Day. Voice of Asia, Vol. 29, No. 28, p7, 2016

41. India’s Permanent Ruling Class: A Curse for Indian Democracy after 70 Years of Independence. Voice of Asia Vol. 29, No. 34, p2, 2016

42. India’s Permanent Ruling Class: A Curse for Indian Democracy after 70 Years of Independence. India Tribune, Vol. 40, No. 18, p6, 2016

43. Term-Limits in Elected Office is Key to Success and Stability of Democracy. Voice of Asia, Vol. 29, No. 38, p2, 2016 44. US Needs to Regulate Immigration to Control its Destiny. Voice of Asia, Vol. 29, No. 40, p2, 2016

45. Presidential Choice between Donald Trump and Hillary Clinton: A Dilemma for Voters and American Democracy. Voice of Asia, Vol. 29, No. 41, p2, 2016

46. Changing American Nationalism in age of Globalization: A Challenge in 2016 Presidential Election. Voice of Asia, Vol. 29, No. 44, p2, 2016

47. Inclusion of Minorities is Essential for President Trump’s Success. Voice of Asia, Vol. 29, No. 46, p2, 2016

48. Inclusion of Minorities is Essential for President Trump’s Success. India Tribune , Vol 40, No. 24, 2016

49. Inclusion of Minorities Essential for Success of President-elect Trump. INDIA-WEST, p6, Dec 2, 2016

50. Ignorance and Bigotry is not Conservatism: A Word of Caution for American Conservative Activists. Voice of Asia , Vol. 29, No. 50, p2, 2016

51. Do You Really Need Added Sugar in Your diet. Healthline , Vol.2, No.4, p17 (2016)

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52. What can President Donald Trump actually deliver? The Challenges for the 45th US PresidentVoice of Asia, Vol. 30, No.2, p2, 2017

53. The Challenges for President-elect Trump. INDIA-WEST , p6, Jan 20, 2017

54. What can President Trump Actually Deliver, INDIA JOURNAL Jan 13, 2017

55. Kansas City Shooting of Indians: Not Political Conspiracy but Act of a Deranged Xenophobe. Voice of Asia , Vol. 30, No.9, p2, 2017

56. American Healthcare - a Privilege or a Right, An Unending Debate and Dilemma for American Political System. Voice of Asia , Vol. 30, No. 12, p4, 2017

57. Kansas Shooting: Isolated Act of a Lunatic Xenophobe? INDIA-WEST , p8, April 7, 2017

58. The First 100-Days Presidential Review Mania: A Media Creation of No Consequence. Voice of Asia, Vol. 30, No. 18, p4, 2017

59. 100-Days Media Mania About Presidential Performance. INDIA-WEST, p.8/16, May 5, 2017

60. Demonetization in India: An Economic Reform with Cultural Dilemma. Voice of Asia, Vol. 30, No. 29, p9, 2017

61. Demonetization: Economic Reform That Hurts, INDIA-WEST, p6, August 4, 2017

62. Has Donald Trump Settled in US Presidency? Voice of Asia, Vol. 30, No. 30, p11, 2017

63. Can Donald Trump be an Effective President after Charlottesville? Voice of Asia, Vol. 30, No. 33, p 2, 2017

64. Can Donald Trump be an Effective President after Charlottesville? INDIA TRIBUNE, Sept 8, 2017

65. SEXUAL MISCONDUCT TRANSCENDS ETHNICITY AND NATIONALITY, INDIA JOURNAL, NOV 16, 2017

66. Sexual Misconduct Transcends Ethnicity and Nationality. Voice of Asia, Vol. 30, No. 45, p 4, 2017

67. Sexual Misconduct Transcends Ethnicity. INDIA-WEST, p. A6, Nov 24, 2017

68. Is President Trump’s Afghanistan Policy Too Transactional to Succeed? Voice of Asia, Vol. 30, No. 48, p 2, 2017

69. Sexual Misconduct Transcends Ethnicity and Nationality. INDIA TRIBUNE, p.6, Dec 2017

70. Politicization of Sexual Harassment is Detrimental to American Democracy. Voice of Asia, Vol. 30, No. 49, p 2, 2017