Curriculum Vitae – Marta Sandini, MD Updated July 2018 Date Prepared: February, 6 th 2019 Name: Marta Sandini Office Address: Via Pergolesi, 33, 20900, Monza, Italy Home Address: Via dei Mille, 14, 20813, Bovisio Masciago (MB), Italy Work Phone: +39 347 4492146 Work Email: [email protected]/ [email protected]Work FAX: - Place of Birth: Current position: Padova – Italy PGY6 General Surgery Residency Program, Milano-Bicocca University, Monza, Italy Education: 10/03-08/07 09/07-07/10 - MD Medicine and Surgery Medicine and Surgery University of Padova University of Milan- Bicocca Postdoctoral Training: 02/11-07/11 08/13- 11/15-5/16 02/17-02/18 Intern Resident Clinical and research fellow Clinical Research Fellow Vascular Surgery General Surgery Pancreatic Surgery Department of Surgery - A.L. Warshaw Institute for Pancreatic Cancer Research Bassini Hospital, Milan - Italy University of Milan- Bicocca - Italy The Pancreas Institute, University of Verona- Italy Massachusetts General Hospital, Harvard Medical School, Boston (MA) - USA Appointments at Hospitals/Affiliated Institutions: 07/11-01/12 Consultant Primary Care Agostoni RSA, Lissone - Italy
Transcript
Curriculum Vitae – Marta Sandini, MD
Updated July 2018
Date Prepared: February, 6th 2019
Name: Marta Sandini
Office Address: Via Pergolesi, 33, 20900, Monza, Italy
Home Address: Via dei Mille, 14, 20813, Bovisio Masciago (MB), Italy
PGY6 General Surgery Residency Program, Milano-Bicocca University, Monza, Italy
Education:
10/03-08/07 09/07-07/10
- MD
Medicine and Surgery Medicine and Surgery
University of Padova University of Milan-Bicocca
Postdoctoral Training:
02/11-07/11 08/13- 11/15-5/16 02/17-02/18
Intern Resident Clinical and research fellow Clinical Research Fellow
Vascular Surgery General Surgery Pancreatic Surgery Department of Surgery - A.L. Warshaw Institute for Pancreatic Cancer Research
Bassini Hospital, Milan - Italy University of Milan-Bicocca - Italy The Pancreas Institute, University of Verona- Italy Massachusetts General Hospital, Harvard Medical School, Boston (MA) - USA
Appointments at Hospitals/Affiliated Institutions:
SIMEU (Italian Society of Emergency Medicine) SINPE (Italian Society of Enteral and Parenteral nutrition) POIS (Perioperative Italian Society) EPC (European Pancreatic Club) IAP (International Association of Pancreatology) AISP (Italian Society for the Study of Pancreas) E-SIS (European Surgical Infection Society)
Member Member Member Member Member Member Member
Honors and Prizes:
2014 2015 2016 2016 2016 2017 2018 2018
Best oral presentation Awarded oral presentation Best oral presentation Travel Grant Young Investigator Travel Award Best Clinical Abstract Hirshberg Award EPC Fellowship recipient Best Abstract
E-SIS, Vienna AISP, Milan E-SIS, Amsterdam EPC, Liverpool APA, Boston APA, San Diego Announced at EPC, Berlin SINPE, Catania
Report of Funded and Unfunded Projects Funding Information: Past
2013-2015 The role of abdominal CT scan in prediction of perioperative outcome in pancreatic
surgery. Unfounded The aim was to validate previous findings suggesting that the body composition at preoperative evaluation could predict the onset of complications.
2015-2016 Surgical outcome after neoadjuvant treatment in borderline resectable and locally
advanced pancreatic cancer. Unfounded.
2017-2018 2017-2018
Perioperative factors associated with survival in pancreatic ductal adenocarcinoma. MGH-HMS Department of Surgery internal Research founds Patient-derived xenograft (PDX) and cell line development from pancreatic neuroendocrine neoplasms and IPMNs. Andrew L. Warshaw Institute for Pancreatic Cancer Research
3
2017-2018 2017-2018 2017-2018
Collection of tissue, blood and urine and bodily fluids from patients with Pancreatic Disease. MGH-HMS Department of Surgery internal Research founds Effect of elapsed time from biliary stent to surgery in the surgical outcome of patients undergoing pancreatoduodenectomy. A European multicenter collaboration. (Unfounded) Effect of different intraoperative fluid administration regimens on outcomes after pancreatoduodenectomy. MGH-HMS Department of Surgery internal Research founds
Current 2017- 2015-
Anthropometric factors associated with malignancy in Intraductal Papillary Mucinous Neoplasms of the pancreas. MGH-HMS Department of Surgery internal Research founds Bioimpedance Vector Analysis in Surgery. Sponsored by AKERN-srl The aim is to validate BIVA in the surgical setting and specifically analyze whether modification in the normal values may affect the patient short- and long-term outcome.
2017- 2018
Implementation of an Enhanced Recovery After Surgery pathway for patients undergoing a Pancreatoduodenectomy at the Massachusetts General Hospital MGH-HMS Department of Surgery internal Research founds Clinical aftermaths of severe resistance pattern microorganism isolation in biliary-stent bearing patients undergoing pancreatoduodenectomy. A European multicenter collaboration. (Unfounded)
Report of Local Teaching and Training Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs):
2016- Pancreatic neoplasms
6th year medical students (University of Milan-Bicocca)
2 hours lesson
Other Mentored Trainees and Faculty:
2014 Melissa Baini, class 2014; conducted doctoral thesis under my supervision. The object of
her research was the impact of adipose tissue on the complication rate after
Matilde Molinelli, class 2015, conducted doctoral thesis under my supervision. The object of her research was the impact of sarcopenia on major complication after pancreatic surgery. Caterina Franco, class 2015; conducted doctoral thesis under my supervision. The object of her research was the accuracy of ERCP in detecting malignancy in patients with biliary stenosis. Michele Borrelli, class 2016; conducted doctoral thesis under my supervision. The object of his research was the utility of perioperative BIVA in prediction of major and medical complication in pancreatic surgery for cancer. Linda Roccamatisi; conducted doctoral thesis under my supervision. The object of her research is the relationship between BIVA and pattern of bacterial resistance in major surgery. Francesca Carissimi; conducted doctoral thesis under my supervision. The object of her research is the association between risk factors and occurrence of infectious complication after CPRE.
Report of Regional, National and International Invited Teaching and Presentations No presentations below were sponsored by outside entities Those presentations below sponsored by outside entities are so noted and the sponsor(s) is (are) identified. National
2014 Surgery in the era of ERAS (presentation) 2015
SINPE course for pharmacists, Milan Preoperative Computed Tomography to Predict and Stratify the Risk of Severe Pancreatic Fistula After Pancreatoduodenectomy (accepted oral abstract) AISP annual meeting, Milan
2015 2016 2016 2017 2018 2018
A high visceral adipose tissue to skeletal muscle ratio as a determinand of major complications after pancreatoduodenectomy for cancer SINPE annual meeting, Naples BIVA for surgical risk assessment in pancreatic cancer patients (accepted oral abstract) SINPE annual meeting, Trieste Preservation of muscle mass during neoadjuvant treatment for pancreatic cancer predicts surgical resectability (accepted oral abstract) SINPE annual meeting, Trieste Changes in Body Composition During Neoadjuvant Treatment for Pancreatic Cancer (accepted oral abstract) Can Bioimpedance Vector Analysis (BIVA) predict the surgical risk in cancer patients undergoing pancreatic surgery? (accepted oral abstract) AISP annual meeting, Rozzano (MI) Frailty, sarcopenia and sarcopenic obesity as new determinants of surgical risk. SINPE II level Class, Perugia (PG) Bioimpedance vector analysis (BIVA) predicts morbidity following pancreatic resection for cancer, SINPE annual meeting, Catania (CT)
International
2014 Effect of Glutamine Dipeptide Supplementation on Primary Outcomes for Elective Major
Preoperative oral carbohydrate load versus placebo in major elective abdominal surgery (PROCY). A randomized, placebo-controlled, multicenter, phase III trial (accepted oral abstract) SIS-E annual meeting, Amsterdam Systematic reveiw and meta-analysis of sutures coated with Triclosan for the prevention of surgical site infection after elective colorectal surgery (accepted oral abstract) SIS-E annual meeting, Amsterdam Surgical resection following neoadjuvant chemotherapy for borderline resectable pancreatic cancer: re-defining the standards (accepted oral presentation) APA annual meeting, Boston, MA, US Changes in Body Composition During Neoadjuvant Treatment for Pancreatic Cancer (accepted oral abstract) APA annual meeting, San Diego, CA, US Preoperative Biliary Stenting and Major Morbidity after Pancreatoduodenectomy - Does Elapsed Time Matter? The FRAGERITA Study Group (accepted oral abstract) European Surgical Society (ESA) Annual Meeting, Trieste, Italy Major complications independently increase long-term mortality after pancreatoduodenectomy for cancer. (accepted oral abstract) SSAT Resident and Fellows Research Conference and DDW (Digestive Disease Week) Washington DC, USA Fluid administration and Surgical Outcomes following Pancreaticoduodenectomy: external Validation at a tertiary Referral Center (accepted oral abstract) ERAS World Congress, Stockholm, Sweden DDW (Digestive Disease Week), Washington DC, USA Fluid administration and Surgical Outcomes following Pancreaticoduodenectomy: external Validation at a tertiary Referral Center (accepted oral abstract)
Report of Clinical Activities and Innovations Current Licensure and Certification:
2011 Italian Medical License
Practice Activities:
2012-2013 2012-2013 2013-
Primary Care Physician General surgery residency
Emergency Medical Service Cesano Maderno (MB), Italy Emergency dep. Lecco Hospital, Italy San Gerardo Hospital, Monza, Italy
24 hours per week 20 hours per week 60 hours per week
Report of Scholarship
Peer-Reviewed Scholarship in print or other media:
6
Research Investigations
1. Sandini M, Bernasconi DP, Ippolito D, Nespoli L, Baini M, Barbaro S, Fior D, Gianotti L. Preoperative Computed Tomography to Predict and Stratify the Risk of Severe Pancreatic Fistula After Pancreatoduodenectomy. Medicine (Baltimore). 2015 Aug;94(31):e1152.
2. Sandini M, Malleo G, Gianotti L. Score for prediction of fistula after pancreatoduodenectomy. A systematic review. Dig Surg. 2016; 33(5):392-400
3. Sandini M, Bernasconi DP, Fior D, Molinelli M, Ippolito D, Nespoli L, Caccialanza R, Gianotti L. A high visceral adipose tissue to skeletal muscle ratio as a determinand of major complications after pancreatoduodenectomy for cancer. Nutrition. 2016: 22 (16)
4. Sandini M, Tamini N, Allegranza P, Franzesi CT, Ippolito D, Gianotti L. The fate of internal pancreato-jejunal anastomosis stenting for pancreatoduodenectomy. Personal experience and review of the literature. Journal of the Pancreas, 2017
5. Famularo S, Giani A, Di Sandro S, Sandini M, Giacomoni A, Pinotti E, Nespoli L, Gianotti L, De Carlis L, Romano F. Parenchymal sparing vs. anatomic resection for HCC: a propensity score analysis. Digestive and Liver Disease, 2017; 49(1)
6. Gianotti L, Biffi R, Sandini M, Marrelli D, Vignali A, Caccialanza R, Viganò J, Sabbatini A, Di Mare G, Alessiani M, Antomarchi F, Valsecchi MG, Bernasconi DP. Preoperative oral charbohydrate Load Versus Placebo in Major Elective Abdominal Surgery (PROCY): A Randomized, Placebo-controlled, Multicenter, Phase III Trial. Ann Surg, 2017; Jun 2
7. Pinotti E, Sandini M, Famularo S, Jaconi M, Romano F, Nespoli L, Gianotti L. Disseminated and late metastatic disease from nasal pit leiomyosarcoma after radical surgical resection. Case report of a singular presentation of a rare disease. Clin Sarcoma Res. 2017; 7: 12.
8. Uggeri F, Pinotti E, Sandini M, Nespoli L, Gianotti L, Romano F. Prognostic factors affecting long-term survival after resection for noncolorectal, nonneuroendocrine, nonsarcoma liver metastases. Gastroenterol Res Pract. 2017;2017:5184146
9. Gianotti L, Tamini N, Gavazzi F, Mariani A, Sandini M, Ferla F, Cereda M, Capretti G, Di Sandro S, Bernasconi DP, De Carlis L, Zerbi A. Consequences of increases in antibiotic resistance pattern on outcome of pancreatic resection for cancer. J Gastrointest Surg. 2017 Jul 5. doi: 10.1007/s11605-017-3483-1.
10. Sandini M, Patino M, Ferrone CR, Alvarez-Pérez CA, Honselmann KC, Paiella S, Catania M, Riva L, Tedesco G, Casolino R, Auriemma A, Salandini MC, Carrara G, Cristel G, Damascelli A, Ippolito D,D’Onofrio M, Lillemoe KD, Bassi C, Braga M, Gianotti L, Sahani D, Fernández -del Castillo C. Association Between Changes in Body Composition and Neoadjuvant Treatment for Pancreatic Cancer. JAMA Surg. 2018;9 [Epub ahead of print]
11. Pecorelli N, Capretti G, Sandini M, Damascelli A, Cristel G, De Cobelli F, Gianotti L, Zerbi A, Braga M. Impact of Sarcopenic Obesity on Failure to Rescue from Major Complications Following Pancreaticoduodenectomy for Cancer: Results from a Multicenter Study. Ann Surg Oncol. 2017;nov 7
12. Famularo S, Giani A, Di Sandro S, Sandini M, Giacomoni A, Pinotti E, Lauterio A, Gianotti L, De Carlis L, Romano F. Does the Pringle maneuver affect survival and recurrence following surgical resection for hepatocellular carcinoma? A western series of 441 patients. J Surg Oncol. 2017 Oct 29. doi:10.1002/jso.24819.
13. Famularo S,Giani A, Di Sandro S, Sandini M, Giacomoni A, Pinotti E, Nespoli L, Gianotti L, De Carlis L, Romano F. Parenchymal sparing vs. anatomic resection for hcc: A propensity score analysis. J Surg Oncol. 2017 Oct 29. doi: 10.1002/jso.24819
7
14. Marchegiani G, Andrianello S, Nessi C, Sandini M, Maggino L, Malleo G, Paiella S, Polati E, Bassi C, Salvia R. Neoadjuvant Therapy Versus Upfront Resection for Pancreatic Cancer: The Actual Spectrum and Clinical Burden of Postoperative Complications. Ann Surg Oncol. 2017 Dec 6. doi: 10.1245/s10434-017-6281-9
15. Famularo S, Di Sandro S, Giani A, Lauterio A, Sandini M, De Carlis R, Buscemi V, Romano F, Gianotti L, De Carlis C. Long-term oncologic results of anatomic vs. parenchyma sparing resection for hepatocellular carcinoma. A propensity score-matching analysis. Eur J Surg Oncol. 2018 [Epub ahead of print]
16. Sandini M, Honselmann KC, Birnbaum DJ, Gavazzi F, Chirica M, Wellner U, Guilbaud T, Bolm L, Angrisani M, Moutardier V, Cereda M, Girard E, Montorsi M, Keck T, Zerbi A, Gianotti L. Preoperative Biliary Stenting and Major Morbidity after Pancreatoduodenectomy - Does Elapsed Time Matter? The FRAGERITA Study Group. Ann Surg. 2018 Nov;268(5):808-814
17. Gianotti L, Sandini M, Biffi R, Marrelli D, Vignali A, Bernasconi DP. Kinetic, determinants, and dynamic consequences of postoperative hyperglycemia in nondiabetic patients undergoing major elective abdominal surgery (KINDER and CO. study) A prospective, longitudinal, observational, multicenter evaluation. Clin Nutr. 2018. pii: S0261-5614(18)31239-1. doi: 10.1016/j.clnu.2018.07.028.
18. Sandini M, Ruscic KJ, Ferrone CR, Qadan M, Eikermann M, Warshaw AL, Lillemoe KD, Castillo CF. Major Complications Independently Increase Long-Term Mortality After Pancreatoduodenectomy for Cancer. J Gastrointest Surg. 2018 Sep 17. doi:10.1007/s11605-018-3939-y.
19. Sandini M, Ruscic KJ, Ferrone CR, Warshaw AL, Qadan M, Eikermann M, Lillemoe KD, Fernández-del Castillo C. Intraoperative Dexamethasone Decreases Infectious Complications After Pancreaticoduodenectomy and is Associated with Long-Term Survival in Pancreatic Cancer. Ann Surg Oncol. 2018 Dec;25(13):4020-4026
20. Sandini M, Fernández-del Castillo C, Ferrone CR, Ruscic KJ, Eikermann M, Warshaw AL, Lillemoe KD, Qadan M. Intraoperative Fluid Administration and Surgical Outcomes Following Pancreaticoduodenectomy: External Validation at a Tertiary Referral Center. World J Surg. 2019 Mar;43(3):929-936.
21. Famularo S, Di Sandro S, Giani A, Lauterio A, Sandini M, De Carlis R, Buscemi V, Uggeri F, Romano F, Gianotti L, De Carlis L. Recurrence Patterns After Anatomic or Parenchyma-Sparing Liver Resection for Hepatocarcinoma in a Western Population of Cirrhotic Patients. Ann Surg Oncol. 2018 Dec;25(13):3974-3981.
22. Honselmann KC, Pergolini I, Castillo CF, Deshpande V, Ting D, Taylor MS, Bolm L, Qadan M, Wellner U, Sandini M, Bausch D, Warshaw AL, Lillemoe KD, Keck T, Ferrone CR. Timing But Not Patterns of Recurrence Is Different Between Node-negative and Node-positive Resected Pancreatic Cancer. Ann Surg. 2019 Jan 18.
Reviews, chapters, monographs and editorials
1. Sandini M, Nespoli L, Oldani M, Bernasconi DP, Gianotti L. Effect of Glutamine Dipeptide Supplementation on Primary Outcomes for Elective Major Surgery: Systematic Review and Meta-Analysis. Nutrients. 2015 Jan 9;7(1):481-499. Review
2. Oldani M, Sandini M, Nespoli L, Coppola S, Bernasconi DP, Gianotti L. Glutamine Supplementation in Intensive Care Patients: A Meta-Analysis of Randomized Clinical Trials.
8
Medicine (Baltimore). 2015 Aug;94(31):e1319.
3. Paiella S, Sandini M,* Gianotti L, Butturini G, Salvia R, Bassi C. The prognostic impact of para-aortic lymph node metastasis in pancreatic cancer: A systematic review and meta-analysis. Eur J Surg Oncol. 2016 Feb 13.
4. Sandini M, Mattavelli I, Nespoli L, Uggeri F, Gianotti L. Systematic review and meta-analysis of sutures coated with triclosan for the prevention of surgical site infection after elective colorectal surgery according to the PRISMA statement. Medicine (Baltimore). 2016 Aug;95(35):e4057
5. Gianotti L, Sandini M. Secondary endpoints: surrogate interest or supplementary table? Ann Transl Med. 2017; 5(1)
6. Sandini M, Pinotti E, Persico I, Picone D, Bellelli G, Gianotti L. Frailty indexes as predictors of morbidity and mortality after major abdominal surgery. Systematic review, meta-analysis, and appraisal of practicality.BJS open. 2017;1(5):128-137
7. Pinotti E, Sandini M, Famularo S, Tamini N, Romano F, Gianotti L. Resection of the caudate lobe for the treatment of hilar cholangiocarcinoma. Systematic review and meta-analysis. Minerva Chir. 2018 [Epub ahead of print]
Thesis: Neuroprotective effect of estrogen in Parkinson disease: in vitro research in human neuroblastoma cells.
In compliance with the Italian legislative Decree no. 196 dated 30/06/2003, I hereby authorize you to use and process my personal details contained in this document.
