CV360.1214

Christopher Duntsch, MD, PhD CV360 – 2014 P 4695006470 – F 3037301253

1525 E. Jamison Place, Centennial, CO, 80122 ----------------------------- EM [email protected]

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Table of Contents – For Quick Reference 2 Education – Undergraduate, Graduate, Post-graduate 2 Medical and Neurosurgical Training and Expertise – Graduate, Post-graduate 2 Research Training and Expertise – Undergraduate, Graduate, Post-graduate 3 Professional Positions and Academic Appointments 4 Honors and Awards – Education, Medicine, Academics, Science 4 Professional Scientific and Clinical Organizations 5 Professional Organizations 5 Life Sciences Groups and Associations 6 Academics: Teaching and Mentoring, Academic Committees, and Scientific Meetings 7 Private and Public Research Grants Awarded for Academic Research 8 Scientific and Clinical Presentations to National and International Meetings 11 Scientific and Clinical Abstracts to National and International Meetings 12 Scientific and Clinical Manuscripts, Book Chapters, Medical Briefs 16 USPTO and WPTO Issued Patents, Disclosures, Licensing, Recent FDA IDE Applications 20 APPENDIX

BIO

IACUC ANIMAL STUDY PROTOCOL APPLICATIONS AND RESEARCH

IRB HUMAN TISSUE BIOBANKING APPLICATIONS AND RESEARCH PROGRAMS

MEDICAL CREDENTIALING, LICENSURE, CONTINUING MEDICAL EDUCATION

AREAS OF BASIC, TRANSLATIONAL, AND CLINICAL SCIENCE EXPERTISE

MOLECULAR NEUROSURGERY RESEARCH PROGRAM

SUGGESTED LIST OF REFERENCES



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EDUCATION AND EXPERTISE 1991 – 1995: University Of Memphis: Departments of Biology and Biochemistry Bachelor of Science, Vertebrate Zoology and Biochemistry Summa Cum Laude, GPA 4.0, Alpha Epsilon Delta Honor Society, Premedical Honor Society, Phi Kappa Phi Honor Society, Dean’s List (4 Years consecutively); MCAT - Score of 33 (top 1% nationally) 1995 – 2002: MD – PHD Combined Studies Program

1997 – 2001 Doctorate of Philosophy (Stem Cell, Cell, and Molecular Biology) University of Tennessee Graduate Health Sciences St Jude Children’s Research Hospital, Department of Biochemistry Summa Cum Laude, GPA 3.95 Graduate Studies Director – James Ihle, PhD

1995 – 1997 / 2001 - 2002 Doctorate of Medicine: University of Tennessee, College of Medicine Summa Cum Laude, GPA 4.0, graduating w/ High Honors, Alpha Omega Alpha Medical Honor Society (top 5% of medical graduates nationally), UT College of Medical Research Award of Excellence, Step 1 – 3 Medical Boards (Top 5% nationally) 2003 – 2009: University Of Tennessee Health Sciences Center 2004 College Of Medicine, General Surgery and Neurology Internships 2009 College Of Medicine, Department Of Neurosurgery Written Neurosurgical Boards 2005 (top 10% nationally) 2009 – 2010: Fellowship – General, Complex, And Minimally Invasive Spine Surgery Semmes Murphey Neurologic & Spine Institute University of Tennessee, Department of Neurosurgery Fellowship Director - Dr. Kevin Foley RESEARCH TRAINING 1994: University of Memphis Departments Of Biology And Genetics Senior Research Internship Program Laboratory of Dr. William Wilson (Chairman of Genetics Department) 1996: St. Jude Children’s Research Hospital Department of Hematology – Oncology, Internship Pediatric Neuroblastoma Cancer Biology National Institute of Health Professional Oncology Grant (Award) Laboratory of Dr. John Cunningham 1997: UTHSC Department of Urology; Gene Therapeutics, Inc. Internship: Gene Therapy with Viral Vectors Laboratory of Dr. Mitchell Steiner, Urology (Chairman and Professor) Laboratory of Dr. Mitchell Steiner, Gene Therapeutics, Inc. (President, CEO)



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1997 – 2001: St Jude Children’s Research Hospital, Department of Biochemistry Graduate Research Training: Cell and Molecular Biology, Cancer Biology, Stem Cell Biology, Hematology – Oncology, Transgenics, Gene Therapy, SCID Biology, Genetics and KO Biologics Doctorate Of Philosophy – Stem Cell, Cell, and Molecular Biology Laboratory Of Dr. James Ihle (Chairman, Department of Biochemistry) 2001 - 2002: St. Jude Children’s Research Hospital Invited Postdoctoral Research Fellowship in Hematology - Oncology STAT5 biology, dominant negatives, mutants – Leukemia, Oncogenesis, CML and CLL subtypes Laboratory Of Dr. James Ihle (Chairman, Department of Biochemistry) 2002 - 2003: University Of Tennessee, College Of Medicine, Department of Neurosurgery Invited Postdoctoral Research Fellowship in Neuro-oncology N-cadherin and glioma tissue invasion, neural stem cells and glioma, DNAzyme molecular technologies against MMP2 and MMP9, to treat glioblastoma in translational models Laboratory of Dr. Jon Robertson (Chairman, Department of Neurosurgery) 2009 - 2010: University Of Tennessee, College Of Medicine, Graduate Health Sciences Postdoctoral Research Fellowship, Biomedical and Biomechanical Engineering Department of Neurosurgery, Department of Biomedical Engineering, Discgenics, Inc. Laboratory of Dr. Kevin Foley, Laboratory Dr. Walleed Gaber PROFESSIONAL POSITIONS AND ACADEMIC APPOINTMENTS 2002 – Present: University Of Tennessee Health Sciences Center College Of Medicine, Department Of Neurosurgery Assistant Professor, Principal Investigator, Lead Scientist, Graduate Professor 2005 – 2011: University Of Tennessee Health Science Center College Of Medicine, Department Of Neurosurgery Molecular Neurosurgery Research Program Program Director, Tissue Bank Director 2007 – 2009: University Of Tennessee Health Science Center College Of Medicine, UT Cancer Research Institute – Neuro-Oncology Associate Program Director 2006 – 2011: Novostem Therapeutics, Inc. Memphis, TN – A Delaware Corporation Founder, President, Chief Science Officer, Board Member, Lead Scientist, Senior Author, Writer, Editor Cancer Stem Cell Biologics; Biotechnology Platforms for High Yield / High Throughput / High Quality Cancer Stem Cell Culture; Next Generation Robotics and Biodetection Biotechnology Interface for drug biology in real time against small molecules being screened; Drug Discovery, & Drug Development of novel chemotherapeutics that target cancer stem cells 2007 – 2012: Discgenics, Inc. Memphis, TN / Salt Lake City, UT – A Delaware Corporation Founder, President, Chief Science Officer, Board Member

Top 100 biotechnology companies in North America (2014)



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Adult Spinal Disc Stem Cell Biology; Discovery of Adult Spinal Disc Tissue Stem Cells; Disc Stem Cell Culture Platform Biotechnologies; Biomedical engineering and stem cell hybrid medical devices; Stem Cell Therapies, Tissue Engineering, and Regenerative Biology; Combination Approaches; Target Population is degenerative disc disease in the aging human population 2008 – 2012: Nuvasive, Inc. Medical Director US Tissue Bank Director (all commercial Biologics) Biologics and Biomedical Engineering Consultant (Licensed in the US by ABTA, biobanking for regulatory in the US) 2011 – 2013: Texas Neurosurgical, PA. Dallas, TX; a Texas Inc. Clinical Director, Neurosurgery Director of R&D Operations and Nonprofits 2010 – Present: A Child’s Life (501c3 nonprofit) Director - Fundraising, awareness, and R&D investment strategy Advocacy group and nonprofit for pediatric neurologic diseases 2007 – Present: Hybrid Bioscience Consulting, Inc. Founder, Director, CSO Bioscience and Business Development Consulting for Academic and Biotechnology Groups (Senior bioconsultant for the Zintro group) (Medtronic / Sofamore Danek, Nuvasive, Genome Explorations, UTHSC Cancer Center, Discgenics, Novostem, Gene Therapeutics, the Memphis Biobanking Consortium, Stem Cell Creations, etc.) 2013 – Present: Synthetic Investments, Inc. Founder, Director, CSO Analyst and Consultant for Life Sciences Investing (subgroup of Hybrid Biosciences) HONORS, AWARDS, & RECOGNITION OF EXCELLENCE IN ACADEMICS AND BIOTECHNOLOGY 2012 - 2014 (ranked in top 2.5% nationally, and internationally, in Academics and Research) 2014 Top 100 Biotechnology Companies in North America (Red Herring) 2014 Best Medical Practice Group and Business (North Dallas) 2013 “Patient’s Choice” award in Neurosurgery 2013 ”Compassionate Physician” award 2013 Top International Physicians and Surgeons 2012 Best Doctor’s Network Award 2012 Better Business Bureau Award 2012 CareStar Clinical Recognition Award by Patients 2011 Best Science Abstract, North American Spine Society 2008 Science Presentation Award, Tennessee Neurosurgical Society 2006 Who’s Who in Medicine Academia 2005 Basic Science Award, Southern Neurosurgical Society 2002 High Honors, University of Tennessee, College of Medicine 2002 Summa Cum Laude, University of Tennessee, College of Medicine 2002 Alumni Achievement Award in Research, College of Medicine 2001 Alpha Omega Alpha Medical Honor Society 2001 Summa Cum Laude, University of Tennessee, Graduate Health Sciences 1995 Summa Cum Laude, University of Memphis 1991 – 1995 Dean’s for Excellence and High GPA status 1993 Phi Kappa Phi, Premedical Honor Society



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1992 Alpha Epsilon Delta, Premedical Honor Society PROFESSIONAL ORGANIZATIONS 2013 – Present Academy of Distinguished Mentors 2013 – Present Texas Medical Association Political Action Committee 2012 – Present Surgical Neurology International, Neurosurgery Market Watch 2012 – Present Spine Associates 2012 – Present Society for Lateral Access Surgery 2012 – Present Society for Minimally Invasive Spine Surgery 2012 – Present Neuroscience Education Institute 2011 – Present Dallas Medical Society, Texas Medical Society 2009 – Present North American Spine Society 2009 – Present International Stem Cell Society 2007 – Present National Tissue Bank Society 2005 – Present Society of Neuro-Oncology 2005 – Present AANS Joint Committee on Neurotrauma and Critical Care 2005 – Present Independent Medicine Political Action Committee 2004 – Present American Association of Neurosurgeons 2004 – Present Congress of Neurosurgeons 2002 – Present Memphis Medical Association 1998 – Present American Medical Association Political Action Committee 1998 – Present National Association of Doctors 1998 – Present Tennessee Medical Association 1995 – Present American Medical Association 1992 – Present American Chemical Society LIFESCIENCE GROUPS AND ASSOCIATIONS Biomathematics, Applied Life Science Mathematics, and Theoretical Biology Biotechnology & Stem Cells, Matrix Biology, Fluid Dynamics, Scaffolding, Bioreactors, Assembly Cancer Stem Cell Biology, Culture Platforms, Drug Screening, Drug Development Cell and Molecular Biology – Education, Training, Research Stem Cell Bioscience – Discovery, Development, Application Stem Cell Biotechnology – Bioscience, Tissue Engineering, and Regenerative Medicine Development of the Adult Spine, Adult Disc Tissue Cell Biology, Degenerative Disc Tissue Biology Minimally Invasive Spine Surgery and Next Generation Biologics Synthetic Investments, Inc. 3D Cell Biology, Tools, Techniques Cell Therapy Industry Group Becker’s Healthcare Cell and Molecular Biology Regenerative Medicine Technology Texas A&M Faculty Learning Communities Program Innovations in Health Innovations in Oncology Invention Entrepreneurs MolecularLab (Community of Molecular Biology & Biotech companies, students, researchers) National Neurotrauma Society International College of Clinical Neurophysiology Life Sciences Medical Device Opportunity Molecular and Cell Biology Neuromedical Device Professionals Neurosurgeons



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Neurosurgery Innovation Network North American Spine Society Patients for Stem Cells Regenerative Medicine Group R&D - Biopharmaceutical, Pharmaceutical and Biotechnology Research and Development Society for Neuroscience Stem Cells and Regenerative Medicine Surgical Neurology International University of Tennessee Health Sciences Center at Memphis X-tech Roundup Minimally Invasive Spine Surgery and Next Generation Biologics Protein Biochemistry and Biophysics SEVEN - Scientific Entrepreneur & Venture Capital Network Peer Reviewed Literature Subgroups and the Minimally Invasive Spine Surgeon Cell Therapy Industry group Medical Devices Group, Medical Devices Group: Diagnostic Imaging Minimally Invasive Spine Surgery – WENMISS National Brain Tumor Society National Neurotrauma Society North American Spine Society The International Society of Intraoperative Neuromonitoring Stem Cell Research Stem Cell Clinical Trials Stem Cells and Regenerative Medicine Life Science Groups Created and Directed and Controlled by Hybrid Bioscience Biomathematics and Applied Life Science Applications Biotechnology and stem cells, matrix biology, fluid dynamics, and polymer science Cancer Stem Cell Biology, Culture, Biotechnology, Drug Discovery Cell and Molecular Biology – Education, Training, Research Developmental Biology of the Human Spine Minimally Invasive Spine Surgery and Next Generation Biologics Stem Cell Bioscience, Discovery, Development, Application Stem Cell Biotechnology – Bioscience, Tissue Engineering, Regenerative Medicine Synthetic Investments Life Science Investment Group ACADEMIC TEACHING, MENTORING – UNIVERSITY OF TENNESSEE HEALTH SCIENCES 2004 – 2011: Colleges of Medicine, Pharmacy, and Graduate Health Sciences Graduate Professor for Teaching Medical and Graduate Studies Adult Primary and Metastatic Brain and Spinal Cord Tumors Pediatric Central Nervous System Tumors Clinical Neuroscience and Neurology Molecular Imaging Strategies for Animal Based Models of Disease 2000 – 2012 Training, & Mentoring: Research, Medicine, and Neurosurgery 2012 – 2013 Yaszen Abusad - Premed Student, Subspecialty Training in Neurosurgery / MIS Spine 2011 – 2012 Raul Cardenas M.D. – Postdoctoral Scientist 2003 – 2011 Umar Akbar, M.D. Research Officer, Discgenics, Inc. 2009 – 2010 Miranda Hallet, PhD. Grad Student, UTHSC Molecular Sciences. 2007 – 2009 Umar Akbar, M.D., Post-doctoral Scientist 2002 – 2008 Rano Chatterjee, Post-doctoral Scientist 2006 – 2009 Erika Dillard, M.D., PhD. student, Neuro-oncology summer fellowship 2006 – 2007 Jamie Riney, Pre-medical Student, Neuro-oncology summer fellowship



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2005 – 2006 Terreia Jones, Pharm.D. Post-doctoral Scientist 2004 – 2007 John Winestone, MD, Neurosurgical Resident 2004 – 2007 James Weimar, MD, PhD, Neurosurgical Resident 2004 – 2007 Divi Murali, PhD, Graduate Student 2003 – 2004 Kenichiro Asano, M.D., PhD., Post-doctoral Scientist 2002 – 2004 Andrew Hanover, Pre-med Student, Neuro-on summer fellowship 2003 – 2004 Dwight Bordelon, Pre-graduate Student 2002 – 2003 Rano Chatterjee, Medical Student, Postdoctoral Fellowship 2002 – 2003 Chad Batson, Medical Student, Neuro-oncology summer fellowship 2005 – 2011 Rick Boop, MD (Chairman, Professor) 2005 – 2011 Jon Robertson, MD (Former Chairman, Professor) 2005 – 2011 Kevin Foley, MD (Professor) 2005 – 2011 Julius Fernandez, MD (Assistant Professor) 2005 – 2011 Bruce Frankel, MD (Assistant Professor) 2005 – 2011 Madison Michael, MD (Assistant Professor) 2005 – 2011 Jeff Sorenson, MD (Assistant Professor) 2005 – 2011 Michael Taylor, MD, PhD (Neurosurgery Fellow) 1996 – 2008 UNIVERSITY ACADEMIC COMMITTEES 2008: University of Tennessee, Neurobiology Chairman Search Committee 2006: Scientific Director of Committee, UTHSC / Johns-Hopkins Neuro-Oncology Update, Memphis, TN 2005 – 2006: Scientific Committee for the Annual Memphis Bioimaging Symposium 1999 – 2000: UTHSC / SJCRH – Graduate Student Lectureship Committee 1996 – 1998: University of Tennessee Committee on Research (Only graduate ever elected to this committee) PRIVATE AND PUBLIC RESEARCH GRANT SUPPORT (selected examples) National Institutes of Health R01CA10718301A2 2009 – 2012 (Renewed) Safety and efficacy of DNAZyme oligos as a novel therapy for high-grade gliomas of the CNS Role on Project: Co-PI (investigator with) Fruz Pourmotabbed, PhD University of Tennessee Health Sciences Center, College of Medicine, Department of Neurosurgery In Collaboration with the Departments of Pharmacology and Molecular Sciences UTHSC Neurosurgery Team Members: Qihong Zhou, MD, PhD, Xiofei Wang, MD, Umar Akbar, MD Funding $: 750K over Four Years National Institutes of Health R01CA10718301A2 2005 – 2009 Safety and efficacy of DNAZyme oligos as a novel therapy for high-grade gliomas of the CNS Role on Project: Co-PI with Fruz Pourmotabbed, PhD University of Tennessee Health Sciences Center, College of Medicine, Department of Neurosurgery In Collaboration with the Departments of Pharmacology and Molecular Sciences UTHSC Neurosurgery Team Members: Qihong Zhou, MD, PhD, Xiofei Wang, MD, Umar Akbar, MD Funding $: 850K over 4 Years Methodist Neuroscience Research Grant 2006 – 2008 (Renewal) Developmental grant for Neurological Diseases Principal Investigator University of Tennessee Health Sciences Center, College of Medicine, Department of Neurosurgery In Collaboration with the Departments of Pharmacology, Pharmaceutical Science, Biomedical Engineering, Physiology, Neurology, Neurobiology, and Molecular Sciences, and St. Jude Children’s Research Hospital Funding $: 1M over 4 Years Methodist Neuroscience Research Grant 2002 – 2006 Developmental grant - Establishing a basic science research program in adult neuro-oncology



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Principal Investigator University of Tennessee Health Sciences Center, College of Medicine, Department of Neurosurgery In Collaboration with the Departments of Pharmacology, Pharmaceutical Science, Biomedical Engineering, Physiology, Neurology, Neurobiology, and Molecular Sciences, and St. Jude Children’s Research Hospital Funding $: 1M over 4 Years Shaneberg Neuroscience Foundation 2005 – 2006 (Renewal) Investigation of qualitative and quantitative differences in gene expression of high-grade gliomas in infants vs. older pediatric patient populations Principal Investigator University of Tennessee Health Sciences Center, College of Medicine, Department of Neurosurgery In Collaboration with Lebonheur Children’s Hospital and St. Jude Children’s Research Hospital UTHSC Neurosurgery Team Members: Qihong Zhou, MD, PhD, Jeff Sorenson, MD, Umar Akbar, MD Funding $: 75K over 1 Year Shaneberg Neuroscience Foundation 2004 – 2005 Safety and efficacy of AAV-mediated gene therapy for the treatment of high-grade glioblastoma. Principal Investigator, with Andrew Davidoff, MD, PhD University of Tennessee Health Sciences Center, College of Medicine, Department of Neurosurgery In Collaboration with St Jude Children’s Research Hospital UTHSC Neurosurgery Team Members: Qihong Zhou, MD, PhD, Xiofei Wang, MD, Umar Akbar, MD Funding $: 25K over 1 Year National Institutes of Health, STTR Phase 1 2004 – 2005 Developing VSV cytolytics against high-grade CNS gliomas. Principal Investigator with Michael Whitt, PhD and Mitch Steiner, MD University of Tennessee Health Sciences Center, College of Medicine, Department of Neurosurgery In collaboration with the Departments of Virology, Molecular Sciences, and Gene Therapeutics, Inc. (GTx) UTHSC Neurosurgery Team Members: Qihong Zhou, MD, PhD, Xiofei Wang, MD, Umar Akbar, MD, Rano Chatterjee, MD, Zixou Wang, MD Funding $: 125K over 1.5 Years Shaneberg Neuroscience Foundation 2005 – 2006 (Renewal) Investigation of qualitative and quantitative differences in gene expression of high-grade gliomas in infants vs. older pediatric patient populations Principal Investigator with Rick Boop, MD University of Tennessee Health Sciences Center, College of Medicine, Department of Neurosurgery In Collaboration with Lebonheur Children’s Hospital and St. Jude Children’s Research Hospital UTHSC Neurosurgery Team Members: Qihong Zhou, MD, PhD, Xiofei Wang, MD, Umar Akbar, MD Funding $: 75K over 1 Year SCIENTIFIC AND MEDICAL PRESENTATIONS (selected examples) Christopher Duntsch, Umar Akbar, and Kevin Foley (2014) Adult spinal disc stem cells, tissue engineering biology, and FDA approved biologic devices for the treatment of degenerative disc disease. Stem Cell : Meeting on the Mesa (Alliance for Regenerative Medicine). Christopher Duntsch, Umar Akbar, and Kevin Foley (2013) Safety, Efficacy, and Pharmacobiology of the first FDA approved pre-IDE pre-clinical translational animal study of biotechnology for stem cell based therapeutics targeting degenerative disc disease. Lumbar Spine Research Society Annual Meeting. New Orleans, LA.



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Christopher Duntsch, Kevin Foley, Umar Akbar (2013) An Adult Disc Stem Cell Biotechnology Culture Platform for the Isolation and Expansion of Spinal Disc Stem Cells that express OCT4 and CD133 ESC and ASC biomarkers respectively. AANS. Dallas, TX. Christopher Duntsch, Kevin Foley, Umar Akbar (2013) An Adult Disc Stem Cell Biotechnology Culture Platform that gives rise to stem cell populations with Notochordal morphology and co-expression of Notochordal biomarkers – Implications for modeling therapeutic strategies. AANS, 2013. Christopher Duntsch, Kevin Foley, Umar Akbar (2013) An Adult Disc Stem Cell Biotechnology Culture Platform for the Isolation and Expansion of Spinal Disc Stem Cells that express OCT4 and CD133 ESC and ASC biomarkers respectively. AANS. Dallas, TX. Christopher Duntsch, MD, PhD (2013) Emerging Business Issues in Spine Surgery – Presentation with Scott Becker. Chicago, IL. Christopher Duntsch, Kevin Foley, Umar Akbar (2013) An tissue culture platform – Disc with Endplate for Creation of Adult Disc Tissue from Adult Disc Stem Cells Resuspended in FGF-B, BMP7, and a Hydrogel Encapsulation. AANS. Dallas, TX. Raul Cardenas, MD, Christopher Duntsch, MD, PhD (2012) In Vitro Tissue Engineering Using Human Adult Disc Stem Cells. Society of Neurosurgery. Istanbul, Turkey.

Christopher Duntsch, MD, PhD, Hamid Shah, MD (2011) A Disc with Endplate Tissue Engineering and Scaffold Model for use with Adult Disc Stem Cells. NASS. Chicago, IL. (Winner of the Society’s Award for Best Science) Christopher Duntsch, MD, PhD (2011) Therapeutic strategies for Minimally Invasive Spine Surgery – Past, Present, and Future: From discectomy to in situ tissue engineering. Medical Update and Presentation – Baylor Plano. Plano, TX.

Christopher Duntsch, MD, PhD (2011) Therapeutic strategies for Minimally Invasive Spine Surgery – Past, Present, and Future: From discectomy to in situ tissue engineering. Dallas – Diagnostics Association – Baylor Plano. Plano, TX.

Christopher Duntsch, MD, PhD (2011) Therapeutic strategies for the treatment of degenerative disc disease – Past, Present, and Future: From discectomy to in situ tissue engineering. Baylor - PRMC, Grand Rounds. Plano, TX. Christopher Duntsch, MD, PhD (2011) Selection of cancer stem cells with embryonic transcription factors for disease modeling and drug discovery. UCSD, Grand Rounds. San Diego, CA.

Christopher Duntsch, MD, PhD (2009) Therapeutic strategies for the treatment of degenerative disc disease – Past, Present, and Future: From discectomy to in situ tissue engineering. University of Tennessee, Department of Neurosurgery, Grand Rounds. Memphis, TN. Christopher Duntsch, MD, PhD: Christopher Duntsch, MD, PhD: Selection of cancer stem cells with embryonic transcription factors for disease modeling and drug discovery. Vanderbilt University, Neurosurgical Grand Rounds. Nashville, TN. November 2008.

Christopher Duntsch, MD, PhD: Christopher Duntsch, MD, PhD: Cancer stem cells can be isolated by expression of OCT4 and are critical determinants of tumorigenesis and metastasis. Academy of Neurosurgeons. Phoenix, AZ. September 2008.

Christopher Duntsch, MD, PhD: In vitro and in vivo characterization of cancer stem cells in solid tumor models. University of Tennessee at Memphis, Neurosurgical Grand Rounds. Nashville, TN. August 2008.



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Christopher Duntsch, MD, PhD: Characterization of cancer stem cells in glioma and other animal models. Tennessee Neurosurgery Association. Nashville, TN. August 2008.

Christopher Duntsch, MD, PhD: Christopher Duntsch, MD, PhD: Christopher Duntsch, MD, PhD: Subaxial Cervical Spine Trauma. Regional Medical Center Neurotrauma Conference. Memphis, TN. March 2008.

Christopher Duntsch, MD, PhD: Neurointensive Care. Regional Medical Center Neurotrauma Series. Memphis, TN. February 2008.

Christopher Duntsch, MD, PhD: Characterization of cancer stem cells in glioma and other solid tumor animal models. UTHSC, Dept. of Neurosurgery, Grand Rounds. Memphis, TN. September 2007.

Christopher Duntsch, MD, PhD: Identification and treatment of coagulopathies in brain trauma. Regional Medical Center Neurotrauma Conference. Memphis, TN. February 2007. Kueter D, Duntsch CD, Divi M, Jones T, Wood G, Moore B, and Sills A. Preclinical studies of KM-233, a safe and effective classical cannabinoid chemotherapeutic for the treatment of high-grade glioma. Southern Neurosurgical Conference. Bermuda. March 2006. Kueter D, Duntsch CD, Divi M, Jones T, Wood G, Moore B, and Sills A. Preclinical studies of KM-233, a safe and effective classical cannabinoid chemotherapeutic for the treatment of high-grade glioma. Southern Neurosurgical Conference. Bermuda. March 2006. Ignatova T, Krutlina R, Nazarova M, Dulatova G, Duntsch CD, and Kukekov V. Tumor stem cells show characteristics of embryonic stem cells unable for cytodifferentiation. American Association of Cancer Research. Proc Amer Assoc Cancer Res. Vol 47, 2006. Gaber W, Duntsch CD. A murine CNS tumor model using combined optical and x-ray molecular imaging techniques BMES, 9/29, Baltimore, MD. September 29th, 2005. Batson CS, Hasegawa H, Zhou Q, Duntsch CD, Pourmotabbed T. Anti-MMP DNAzymes: A Novel Therapeutic Strategy in Glioma Treatment. Gordon Research Conference on the Matrix Metalloproteinases. Big Sky, Montana August 28th-Sept. 2nd, 2005. Duntsch CD, Divi M, Jones T, Wood G, Moore B, and Sills A. In vitro safety and efficacy of a novel CB2-selective cannabinoid chemotherapeutic agent, KM-233, for the treatment of high-grade glioma. Society for Neuro-oncology. Edinborough, Scotland. May 2005. Duntsch CD, Jayakar J, Zhou Q, Xiang Z, Pfeffer L, Robertson J, and Whitt M. Efficacy and Safety of a Replication-Restricted VSV for the Treatment of Glioblastoma using Organotypic Brain Slice and Rodent Models of Intracranial Glioma. Society for Neuro-oncology. Edinborough, Scotland. May 2005. Murali D, Wood G, Krishnamurthy M, Nazarova M, Thoma L, Moore, B, and Duntsch CD. Development and evaluation of parenteral formulations for a new chemical entity. Poster. HARM FORUM, American Association of Pharmaceutical Scientists, Parenteral Drug Association. Annual Graduate Symposium. Memphis, TN. 2005. (1st Place, Graduate Student Category). Murali D, Wood G, Krishnamurthy M, Nazarova M, Thoma L, Moore, B, and Duntsch CD. Development and evaluation of parenteral formulations for a new chemical entity. Poster. HARM FORUM, American Association of Pharmaceutical Scientists, Southern Region Annual Meeting. Memphis, TN. 2004. Akbar U, Janjetovic Z, Teng B, Duntsch CD, Zhou Q, Sorenson J, Robertson JH, Hanissian SH. cDNA characterization of a novel gene MLF1-IP in human Glioblastoma. Poster. University of Tennessee Cancer Institute Annual Meeting. Memphis, TN. 2004. (First Place, Post-doctoral Scientist Category)



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Batson C, Duntsch CD, Hasegawa H. Zhou Q. Pourmotabbed T. DNAzymes: A Novel Therapeutic Strategy in Glioma Treatment. Poster. University of Tennessee Cancer Institute Annual Meeting. Memphis, TN. 2004. (Ralph R. Braund Young Investigator Award) Zhou Q, Duntsch CD, Jayakar HR, Weimar JD, Whitt MA. A novel organotypic brain slice-glioma co-culture model for studying recombinant VSV oncolytic vectors. Poster. Society for Neuroscience. Los Angeles, CA. 2003. Duntsch CD. Structure – Function Analysis of JAKs-STATs and their receptors in myeloid and lymphoid biology and cancers. Presentation. UTHSC Graduate Sciences Dissertation. Memphis, TN, 2000. Duntsch CD. Structure – Function Analysis of JAKs-STATs and their receptors in myeloid and lymphoid biology and cancers. Presentation. Howard Hughes Institute. Bethesda, MA. 2000. SCIENTIFIC AND MEDICAL ABSTRACTS FOR MEETINGS Foley KT and Duntsch CD (2013) Rescue of a degenerated disc rabbit model with adult disc stem cells isolated and prepared for trans annular injection. Society of Spine. New Orleans, LA.

Akbar U, Dulatova G, Teng B, Naqvi SH, Cardenas R, Shah H, Foley KT, Kukekov VG, and Duntsch CD (2013) Isolation and Characterization of Disc Stem Cells from Human Adult Disc Tissue with a Novel Stem Cell Culture Platform. AANS. New Orleans, LA.

Akbar U, Dulatova G, Teng B, Naqvi SH, Cardenas R, Shah H, Kukekov VG, Foley KT, and Duntsch CD (2013) Isolation and Characterization of Disc Stem Cells from Human Adult Degenerated Disc Tissue – a Balance of Variability and Potential. AANS. New Orleans, LA.

Akbar U, Dulatova G, Teng B, Naqvi SH, Cardenas R, Shah H, Kukekov VG, Foley KT, Duntsch CD (2013) In Vitro Tissue Engineering of Nucleus Pulposus Using Adult Degenerated Disc Stem Cells. AANS. New Orleans, LA.

Shah H, Akbar U, Wang X, Zhou Q, Kukekov VG, Foley KT, and Duntsch CD (2011) A Disc with Endplate Tissue Scaffold Model Using Human Adult Disc Stem Cells. NASS. Chicago, IL. (Winner of the Society’s Scientific Award for Best Science Abstract Submission). Duntsch CD and Akbar UA. Coordinate regression in multi-variate analysis of bioengineered reporter systems that correlate function with signal intensity. Society of Biomathematical Engineering. Paris, France. January 2010. Duntsch CD, Kukekov VK, Ignatova T. Selection of Cancer Stem Cells with the Biomarker OCT4 for Disease Modeling and Drug Discovery. AANS. San Diego. 2009. Duntsch CD, and Kukekov VK. OCT4-selected cancer stem cells are critical determinants of tumorigenesis and metastasis in a novel animal model of breast cancer. AANS. San Diego, CA. May 2009. Williams R, Sims T, Myers J, Duntsch CD, and Davidoff A. Local gene transfer of interferon-B for the treatment of glioblastoma xenografts. American College of Surgeons. Chicago, IL. 2009. Ignatova T, Krutilina R, Chatterjee R, Dulatova G, Pavicevic Z, Teng B, Wang Y, Duntsch CD, and Kukekov VK. Enhanced malignancy and ES cell-specific molecular portrait of tumor cells stably expressing GFP driven by the POU5F1/OCT4 promoter. AACR. Chicago, IL. 2009.



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Jones T, Johns C, Barnes J, and Duntsch CD. Development of a murine model of anti-leukemic therapy induced brain tumors. Barcelona, Spain. September 2008. Ignatova T, Krutilina R, Chatterjee R, Dulatova G, Duntsch CD, and Kukekov V. Novel cancer stem cell model for human solid tumors: Molecular profiling and tumorigenicity of tumor cells expressing developmental markers. AACR. February 2008. Kueter D, Duntsch CD, Divi M, Jones T, Wood G, Moore B, and Sills A. Preclinical studies of KM-233, a safe and effective classical cannabinoid chemotherapeutic for the treatment of high-grade glioma. Southern Neurosurgical Conference. Bermuda. March 2006. Kueter D, Duntsch CD, Divi M, Jones T, Wood G, Moore B, and Sills A. Preclinical studies of KM-233, a safe and effective classical cannabinoid chemotherapeutic for the treatment of high-grade glioma. Southern Neurosurgical Conference. Bermuda. March 2006. Ignatova T, Krutlina R, Nazarova M, Dulatova G, Duntsch CD, and Kukekov V. Tumor stem cells show characteristics of embryonic stem cells unable for cytodifferentiation. American Association of Cancer Research. Proc Amer Assoc Cancer Res. Vol 47, 2006. Gaber W, Duntsch CD. A murine CNS tumor model using combined optical and x-ray molecular imaging techniques BMES, 9/29, Baltimore, MD. September 29th, 2005. Batson CS, Hasegawa H, Zhou Q, Duntsch CD, Pourmotabbed T. Anti-MMP DNAzymes: A Novel Therapeutic Strategy in Glioma Treatment. Gordon Research Conference on the Matrix Metalloproteinases. Big Sky, Montana August 28th-Sept. 2nd, 2005. Duntsch CD, Divi M, Jones T, Wood G, Moore B, and Sills A. In vitro safety and efficacy of a novel CB2-selective cannabinoid chemotherapeutic agent, KM-233, for the treatment of high-grade glioma. Society for Neuro-oncology. Edinborough, Scotland. May 2005. Duntsch CD, Jayakar J, Zhou Q, Xiang Z, Pfeffer L, Robertson J, and Whitt M. Efficacy and Safety of a Replication-Restricted VSV for the Treatment of Glioblastoma using Organotypic Brain Slice and Rodent Models of Intracranial Glioma. Society for Neuro-oncology. Edinborough, Scotland. May 2005. Murali D, Wood G, Krishnamurthy M, Nazarova M, Thoma L, Moore, B, and Duntsch CD. Development and evaluation of parenteral formulations for a new chemical entity. Poster. HARM FORUM, American Association of Pharmaceutical Scientists, Parenteral Drug Association. Annual Graduate Symposium. Memphis, TN. 2005. (1st Place, Graduate Student Category). Murali D, Wood G, Krishnamurthy M, Nazarova M, Thoma L, Moore, B, and Duntsch CD. Development and evaluation of parenteral formulations for a new chemical entity. Poster. HARM FORUM, American Association of Pharmaceutical Scientists, Southern Region Annual Meeting. Memphis, TN. 2004. Akbar U, Janjetovic Z, Teng B, Duntsch CD, Zhou Q, Sorenson J, Robertson JH, Hanissian SH. cDNA characterization of a novel gene MLF1-IP in human Glioblastoma. Poster. University of Tennessee Cancer Institute Annual Meeting. Memphis, TN. 2004. (First Place, Post-doctoral Scientist Category) Batson C, Duntsch CD, Hasegawa H. Zhou Q. Pourmotabbed T. DNAzymes: A Novel Therapeutic Strategy in Glioma Treatment. Poster. University of Tennessee Cancer Institute Annual Meeting. Memphis, TN. 2004. (Ralph R. Braund Young Investigator Award) Zhou Q, Duntsch CD, Jayakar HR, Weimar JD, Whitt MA. A novel organotypic brain slice-glioma co-culture model for studying recombinant VSV oncolytic vectors. Poster. Society for Neuroscience. Los Angeles, CA. 2003.



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PUBLICATIONS (selected examples) Duntsch C, Akbar U (2015) Tissue Engineering with ECM libraries in a 7-panel assay protocol. Isolation and Characterization of Adult Spinal Disc Stem Cells from Healthy Human Spinal Disc Tissues. Journal of Cell Science and Report Therapy (Manuscript submitted and under review). Christopher Duntsch, MD, PhD, Rano Chatterjee, MD, Zoran Pavecevic, MD, Zorica Janjetovic, MD, Mariya Nazarova, PhD, Qihong Zhou, MD, PhD, James Weimar, MD, PhD, Jeff Sorenson, MD, Erika Dillard, MD, PhD, Terreia Jones, PharmD, Umar Akbar, MD, Jon Robertson, MD (2014) Isolation And Characterization Of Adult Spinal Disc Stem Cells From Healthy Human Spinal Disc Tissue. Journal of Stem Cell Research and Therapy (Manuscript submitted and under review). Christopher Duntsch, MD, PhD, Rano Chatterjee, MD, Zoran Pavecevic, MD, Zorica Janjetovic, MD, Mariya Nazarova, PhD, Qihong Zhou, MD, PhD, James Weimar, MD, PhD, Jeff Sorenson, MD, Erika Dillard, MD, PhD, Terreia Jones, PharmD, Umar Akbar, MD, Jon Robertson, MD (2014) Histologic assays with Alcian Blue, Toluidine, and H&E tissue stains of NP cells differentiated from adult spinal disc stem cells in Tissue Engineering Assays and their secretion of extracellular matrix. Journal of Cytology and Histology (Manuscript submitted and under review). Christopher Duntsch, MD, PhD (2014) A Historical Review of Minimally Invasive Spine Surgery. Journal of Spine. (Manuscript submitted and under review). Christopher Duntsch, MD, PhD, Rano Chatterjee, MD, Zoran Pavecevic, MD, Zorica Janjetovic, MD, Mariya Nazarova, PhD, Qihong Zhou, MD, PhD, James Weimar, MD, PhD, Jeff Sorenson, MD, Erika Dillard, MD, PhD, Terreia Jones, PharmD, Umar Akbar, MD, Jon Robertson, MD (2014) In vitro tissue engineering with adult disc tissue stem cells. Tissue Engineering. (Manuscript submitted and under review). Christopher Duntsch, MD, PhD, Rano Chatterjee, MD, Zoran Pavecevic, MD, Zorica Janjetovic, MD, Mariya Nazarova, PhD, Qihong Zhou, MD, PhD, James Weimar, MD, PhD, Jeff Sorenson, MD, Erika Dillard, MD, PhD, Terreia Jones, PharmD, Umar Akbar, MD, Jon Robertson, MD (2014) Notochordal cells derived from stem cell suspension culture of adult spinal disc stem cells: proof of phenotype from culture assays, morphology of the culture products, and co-expression of mesoderm and ectoderm intermediate cytoskeleton proteins that are biomarkers of Notochordal cells. Developmental Biology. (Manuscript submitted and under review). Christopher Duntsch, MD, PhD, Rano Chatterjee, MD, Zoran Pavecevic, MD, Zorica Janjetovic, MD, Mariya Nazarova, PhD, Qihong Zhou, MD, PhD, James Weimar, MD, PhD, Jeff Sorenson, MD, Erika Dillard, MD, PhD, Terreia Jones, PharmD, Umar Akbar, MD, Jon Robertson, MD (2014) Modeling of adult spinal disc stem cells and spinal disc tissue biology in the fetal, neonatal, young adult, and elderly human spine, and the influence degenerative disc disease. Journal of Cell Science in Aging. (Manuscript submitted and under review). Christopher Duntsch, MD, PhD, Rano Chatterjee, MD, Zoran Pavecevic, MD, Zorica Janjetovic, MD, Mariya Nazarova, PhD, Qihong Zhou, MD, PhD, James Weimar, MD, PhD, Jeff Sorenson, MD, Erika Dillard, MD, PhD, Terreia Jones, PharmD, Umar Akbar, MD, Jon Robertson, MD (2014) Cancer stem cells can be isolated by expression of OCT4 and are critical determinants of tumorigenesis. Cancer Stem Cells. (Manuscript submitted and under review). Batson C, Hasegawa H, Zhou Q, Duntsch CD, Hallet M, Akbar U, and Pourmotabbed T. (2014) Anti-MMP-9 DNAzyme Arrests Glioma Tumor Progression in Immunocompetent Rodent Models of Glioma. Molecular Medicine. (Manuscript accepted with revision).



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Christopher Duntsch, MD, PhD, Rano Chatterjee, MD, Zoran Pavecevic, MD, Zorica Janjetovic, MD, Mariya Nazarova, PhD, Qihong Zhou, MD, PhD, James Weimar, MD, PhD, Jeff Sorenson, MD, Erika Dillard, MD, PhD, Terreia Jones, PharmD, Umar Akbar, MD, Jon Robertson, MD (2014) OCT4-selected cancer stem cells are critical determinants of tumorigenesis and metastasis in a novel animal model of breast cancer. Science. (Manuscript submitted and under review). Gurley SN, Abidi AH, Allison P, Guan P, Duntsch C, Robertson JH, Kosanke SD, Keir ST, Bigner DD, Elberger AJ, Moore BM (2013) Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233. J Neurooncol. 110(2):163-177. Erika Dillard, Christopher Duntsch, Lawrence Pfeffer, and Michael Whitt (2013) Host cell specific responses to a novel rVSV oncolytic vector rNCP12.1. Gene Therapy and Antisense Approaches. 531;169. Boop FA, Taylor M, and Duntsch CD. Ependymoma (2013) Therapeutic strategies for local recurrent malignant glioma. Youman’s Neurosurgery: ISBN: 978-1-4160-5316-3, Chapter 200. Zawaski J, Gaber W, Sabek O, Wilson C, Duntsch CD, and Merchant TE. (2012) Effects of hypofractionated irradiation on brain vasculature using an in situ tumor model. International Journal of Radiation Oncol Biol Phys. 1;82(3):1075-82. Christopher Duntsch, Hamid Shah, Umar Akbar, and Kevin Foley (2011) A Disc with Scaffold Endplate Scaffold Model Using Human Adult Disc Stem Cells. Volume 11, Issue 10, Suppl, PS137. Denbo JW, Williams RF, Orr WS, Sims TL, Ng CY, Zhou J, Spence Y, Morton CL, Nathwani AC, Duntsch CD, Pfeffer LM, Davidoff AM. (2011) Continuous local delivery of interferon beta tumor vasculature in an orthotopic glioblastoma xenograft resection model. Surgery. 150(3):497-504. McGee MC, Hamner JB, Williams RF, Rosati SF, Sims TL, Ng CY, Gaber MW, Calabrese C, Wu J, Nathwani AC, Duntsch C, Merchant TE, Davidoff AM. (2010) Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation. Int J Radiat Oncol Biol Phys. 76(5):1537-45. Akbar U, Jones T, Winestone J, Shukla A, Michael M, Sun Y, and Duntsch CD. (2009) Delivery of Temozolamide to the tumor bed via a biodegradable gel matrices in a novel model of intracranial glioma with resection. Journal of Neuro-oncology. 94(2):203-212. Boop FA, Medkour A, Duntsch CD (2007) In vitro testing of current spread during ventricular catheter coagulation using diathermy. J Neurosurg. 2007 February;106(2 S):165-168. Boop FA, Medkour A, Duntsch CD, Cherny B (2007) Post-operative Swallowing function after posterior fossa tumor resection in pediatric patients. J Neurosurg Pediatr 3:100 – 108. Duntsch CD, Divi MK, Jones T, Zhou Q, Krishnamurthy M, Boehm P, Sills A, Ii BM, Nazarova M, Moore B, and Wood G. (2005) Safety and efficacy of a novel cannabinoid chemotherapeutic, KM-233, for the treatment of high-grade glioma. J Neurooncol. 29:1-10. Gaber W, Wilson CM, Duntsch CD, Shukla H, Zawaski JA, Vangalaa S, Keyes GS, and DiBianca FA. (2005) Volumetric Analysis of tumors in rodents using the variable resolution x-ray (VRX) CT-scanner. Proc. SPIE Int. Soc. Opt. Eng. 5746:9-5715. Hanissian S, Teng B, Akbar U, Janjetovic Z, Zhou Q, Duntsch CD, and Robertson JH. (2005) Regulation of Myeloid Leukemia Factor-1 Interacting Protein (MLF1IP) Expression in Glioblastoma. Brain Research 1047(1):56-66.



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Duntsch CD, Zhou Q, Weimar JD, Robertson JH, and Pourmotabbed T. (2005) Up-regulation of neuropoiesis generating Nestin immunoreactive cells that infiltrate tumor in a rat intracranial glioma model. Journal of Neuro-oncology 71(3):245-255. Sills A, Duntsch CD, Weimar J. Therapeutic Strategies for Local Recurrent Malignant Glioma. (2004) Therapeutic strategies for local recurrent malignant glioma. Curr Treat Options Oncol. December;5(6):491-497. Moriggl R, Sexl V, Kenner L, Duntsch CD, Stangl K, Gingras S, Hoffmeyer A, Bauer A, Piekorz R, Wang D, Wagner E, Ihle J, and Beug H. (2004) Stat5 tetramers control cell-cycle progression and multi-lineage leukemia. Cancer Cell 7(1):87-89. Asano K, Duntsch CD, Zhou Q, Weimar JD, Bordelon D, Robertson JH, Pourmotabbed T. (2004) Correlation of N-cadherin expression in high grade gliomas with tissue invasion. Journal of Neuro-oncology 70;1: 3 – 15. Duntsch CD, Zhou Q, Jayakar HR, Weimar JD, Robertson JH, Pfeffer LM, Wang L, Xiang Z, Whitt MA. (2004) Recombinant vesicular stomatitis virus vectors as oncolytic agents in the treatment of high-grade gliomas in an organotypic brain tissue slice-glioma coculture model. Journal of Neurosurgery 100:1049-1059. BOOK CHAPTERS (selected examples) Boop FA, Taylor M, and Duntsch CD. Ependymoma (2012) Therapeutic strategies for local recurrent malignant glioma. (ISBN: 978-1-4160-5316-3, Chapter 200) Youman’s Neurosurgery. Sills A, Duntsch CD, Weimar J. Therapeutic Strategies for Local Recurrent Malignant Glioma. (2004) Therapeutic strategies for local recurrent malignant glioma. Curr Treat Options Oncol. December;5(6):491-497. Duntsch CD. Structure – Function Analysis of JAK-STAT Kinases and Their Receptors at the Functional ~ Translational, Cell, Molecular Level, Using the Jak3 -/- SCID Model, bone marrow transplants, molecular gene splicing, gene therapy, and evolutionary biologic principles of modeling (2001) NEUROSURGICAL HEALTH ARTICLES SUBMITTED WITH THE BAYLOR HEALTHCARE SYSTEM (selected examples) How to create a back friendly work environment. http://www.baylorhealth.com/PhysiciansLocations/Plano/About/BaylorPlanoHealthBriefs/Pages/Back-Friendly.aspx Is Surgery Right For You? -http://www.baylorhealth.com/PhysiciansLocations/Plano/About/BaylorPlanoHealthBriefs/Pages/Is.aspx Get Your Back Back http://www.baylorhealth.com/PhysiciansLocations/Plano/About/BaylorPlanoHealthBriefs/Pages/Back%20Pain.aspx Decoding Your Pain -http://www.baylorhealth.com/PhysiciansLocations/Plano/About/BaylorPlanoHealthBriefs/Pages/Decoding.aspx In Motion: Exercises To Relieve Back Pain - Walk Tall, Recovering from a back injury?



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http://media.baylorhealth.com/media_storage/BL091103_Garland_bookLR.pdf Back Pain, High Impact Exercises, and Poorly fitted running shoes go hand in hand http://media.baylorhealth.com/media_storage/BL091103_Garland_bookLR.pdf Back In Action -http://www.baylorhealth.com/PhysiciansLocations/AllSaints/About/BaylorFortWorthNews/Pages/BackinAction.aspx Beating Migraine Pain http://media.baylorhealth.com/media_storage/BL091110_Plano_bookLR.pdf Dallas Memory Center: Maintain A Sharp Memory http://media.baylorhealth.com/media_storage/WHQ_Plano_Fall_2011.pdf Where did my Memory Go? http://media.baylorhealth.com/media_storage/WHQ_Plano_Fall_2011.pdf ACADEMIC DISCLOSURES, TECH TRANSFER LICENSE AGREEMENTS Duntsch CD: Human Cancer Stem Cells Derived from Solid Tumors: Isolation and Characterization. Date Filed: 08/07/07. UTHSC Tech Transfer Office. 2008, 25 year License to Operate with Cancer Stem Cell Biotechnology, Memphis, TN. Duntsch CD: Human Cancer Stem Cells Derived from Solid Tumors: Isolation and Characterization. Date Filed: 05/07/06. UTHSC, Memphis, TN. Jayakar J, Duntsch CD, and Whitt M. Use of Recombinant Vesicular Stomatitis Virus encoding G-stem to treat Glioma. Date Filed: 01/31/04. UTHSC, Memphis, TN. PATENTS Duntsch CD, Kukekov V, Akbar U (2014 / P234050). WO-US2. Human disc tissue. Discgenics, Inc. Duntsch CD, Kukekov V, Akbar U (PCT/US2012/025066) Human disc stem cells and biomaterials. 61/442315 2011-02-14. Discgenics, Inc. Duntsch CD, Kukekov V, Akbar U (2014 /234050). Human disc stem methods and biomaterials. PCT/US2012/025066 / 02/11. Discgenics, Inc. Duntsch CD, Kukekov V, Akbar U [fr] Tissue discal humain, [de] Menschliches Bandscheibengewebe, [en] Human disc tissue. DISCGENICS January 1, 2014: EP2679672-A1. Duntsch CD, Kukekov V, Akbar U (P234050.wo-us2) Human disc tissue. (2014 / 234050) PCT/US2012/025066 (2/11) Discgenics, Inc. Duntsch CD, Kukekov V, Akbar U (2012 / 112564) Compositions of adult disc stem cells for the treatment of degenerative disc disease. US 08227246. Discgenics, Inc. Duntsch CD, Kukekov V, Akbar U (PCT/US2012/025066) Human disc stem cells and biomaterials. 61/442315 2011-02-14. Discgenics, Inc. Duntsch CD, Kukekov V, Akbar U (2012) Human disc stem methods and biomaterials. PCT/US2012/025066 / 13/112599 0511. Discgenics, Inc.



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Duntsch CD, Kukekov V, Akbar U (2012 / 112564) Compositions of adult disc stem cells for the treatment of degenerative disc disease. US 2012:20114713-A1. Discgenics, Inc. Duntsch CD, Kukekov V, Akbar U (2012 / 112564) Human Disc Tissue. US 2009:20099007. Discgenics, Inc. Duntsch CD, Kukekov V, Akbar U (2012 / 112564) Human disc stem cells, isolation and culture methods, and compositions comprising the same. WO 2012/112564. Issued. Discgenics, Inc. Duntsch CD, Kukekov V, Akbar U. TISSUS DISCAUX HUMAINS, HUMAN DISC TISSUE. August 23, 2012: WO/2012/112564. Discgenics, Inc. Duntsch CD, Kukekov V, Akbar U (2011 / 20120114713) Compositions of adult disc stem cells for the treatment of degenerative disc disease. US 2012:20100607-A1. Discgenics, Inc. Duntsch CD, Kukekov V, Akbar U (2011 / 20120100607) Compositions of adult disc stem cells for the treatment of degenerative disc disease. US 2012:20100607-A1. Discgenics, Inc. Duntsch CD, Kukekov V, Akbar U [fr] TISSUS DISCAUX HUMAINS, [de] MENSCHLICHES BANDSCHEIBENGEWEBE, [en] HUMAN DISC TISSUE. DISCGENICS April 28, 2010: EP2179030-A1 Duntsch CD, Kukekov V, Akbar U (2010 / CN200880106682) Human Disc Tissue. Discgenics, Inc. Duntsch CD, Kukekov V, Akbar U Neoplastic stem cell systems and methods. Novostem Therapeutics, May 14, 2009: WO/2009/061837. Duntsch CD, Kukekov V, Akbar U (2009) Compositions enriched in neoplastic stem cells and methods comprising same. University of Tennessee Research Foundation. March 11, 2009: EP2032694-A1. Duntsch CD, Kukekov V, Akbar U (2009) Compositions enriched in neoplastic stem cells and methods comprising same. University of Tennessee Research Foundation. August 5, 2009: CN200780029201. Duntsch CD, Kukekov V, Akbar U Human disc tissue. Discgenics. January 15, 2009: WO/2009/009020. Duntsch CD, Kukekov V, and Ignatova T (2009) Compositions enriched in neoplastic stem cell populations and methods comprising the same. WO 2007/80029201. UTRF. Kukekov V, Duntsch CD, and Ignatova T (2009) Preparations characterized by special physical form implant or insert surgical implant or materials therein. 2009/0074835. Discgenics, Inc. Duntsch CD, Kukekov V, and Ignatova T (2009) Neoplastic stem cell populations and methods comprising the same. WO 2009/061837. Novostem Therapeutics, Inc. Duntsch CD, Kukekov V, Ignatova T (2009) Neoplastic stem systems and methods. 2009/EP2032694. University of Tennessee Research Foundation. Duntsch CD, Kukekov V, and Ignatova T (2009) Compositions enriched in adult nucleus pulposus stem cells and methods comprising the same. WO 2009/009020. Discgenics, Inc. Duntsch CD, Kukekov V, and Ignatova T (2008) Compositions enriched in neoplastic stem cells and methods comprising the same. WO 2008/145901. Novostem Therapeutics, Inc. Duntsch CD, Kukekov V, and Ignatova T (2007) Compositions enriched in neoplastic stem cells and methods comprising the same. WO 2007/145901.



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Recent FDA IND or IDE Applications

Spinal Disc Stem Cell Tissue Engineering & Regenerative Medicine of Degenerative Spine Disease 2011 Pre-IDE Submitted, Approved 2013 - 2014 Pre-IDE and large preclinical study completed, submitted to FDA 2014 IDE approved by FDA 2014 Biologic Device IDE approved by FDA for human clinical trials in 2015 Recent Scientific Journal Editorial Appointments Journal of Cell Science and Report Journal of Spine Recent Invitations to Submit Scientific Manuscripts Journal of Cell Science and Report Journal of Aging Biology Journal of Virology Tissue Engineering Journal of Cancer Stem Cell Biology Manuscripts in Preparation Duntsch C, Akbar U (2015) Tissue Engineering with ECM libraries in a 7-panel assay protocol. Isolation and Characterization of Adult Spinal Disc Stem Cells from Healthy Human Spinal Disc Tissues. Journal of Cell Science and Report Therapy (Manuscript submitted and under review). Christopher Duntsch, MD, PhD, Rano Chatterjee, MD, Zoran Pavecevic, MD, Zorica Janjetovic, MD, Mariya Nazarova, PhD, Qihong Zhou, MD, PhD, James Weimar, MD, PhD, Jeff Sorenson, MD, Erika Dillard, MD, PhD, Terreia Jones, PharmD, Umar Akbar, MD, Jon Robertson, MD (2014) Isolation And Characterization Of Adult Spinal Disc Stem Cells From Healthy Human Spinal Disc Tissue. Journal of Stem Cell Research and Therapy (Manuscript submitted and under review). Christopher Duntsch, MD, PhD, Rano Chatterjee, MD, Zoran Pavecevic, MD, Zorica Janjetovic, MD, Mariya Nazarova, PhD, Qihong Zhou, MD, PhD, James Weimar, MD, PhD, Jeff Sorenson, MD, Erika Dillard, MD, PhD, Terreia Jones, PharmD, Umar Akbar, MD, Jon Robertson, MD (2014) Histologic assays with Alcian Blue, Toluidine, and H&E tissue stains of NP cells differentiated from adult spinal disc stem cells in Tissue Engineering Assays and their secretion of extracellular matrix. Journal of Cytology and Histology (Manuscript submitted and under review). Christopher Duntsch, MD, PhD (2014) A Historical Review of Minimally Invasive Spine Surgery. Journal of Spine. (Manuscript submitted and under review). Christopher Duntsch, MD, PhD, Rano Chatterjee, MD, Zoran Pavecevic, MD, Zorica Janjetovic, MD, Mariya Nazarova, PhD, Qihong Zhou, MD, PhD, James Weimar, MD, PhD, Jeff Sorenson, MD, Erika Dillard, MD, PhD, Terreia Jones, PharmD, Umar Akbar, MD, Jon Robertson, MD (2014) In vitro tissue engineering with adult disc tissue stem cells. Tissue Engineering. (Manuscript submitted and under review).



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Christopher Duntsch, MD, PhD, Rano Chatterjee, MD, Zoran Pavecevic, MD, Zorica Janjetovic, MD, Mariya Nazarova, PhD, Qihong Zhou, MD, PhD, James Weimar, MD, PhD, Jeff Sorenson, MD, Erika Dillard, MD, PhD, Terreia Jones, PharmD, Umar Akbar, MD, Jon Robertson, MD (2014) Notochordal cells derived from stem cell suspension culture of adult spinal disc stem cells: proof of phenotype from culture assays, morphology of the culture products, and co-expression of mesoderm and ectoderm intermediate cytoskeleton proteins that are biomarkers of Notochordal cells. Developmental Biology. (Manuscript submitted and under review). Christopher Duntsch, MD, PhD, Rano Chatterjee, MD, Zoran Pavecevic, MD, Zorica Janjetovic, MD, Mariya Nazarova, PhD, Qihong Zhou, MD, PhD, James Weimar, MD, PhD, Jeff Sorenson, MD, Erika Dillard, MD, PhD, Terreia Jones, PharmD, Umar Akbar, MD, Jon Robertson, MD (2014) Modeling of adult spinal disc stem cells and spinal disc tissue biology in the fetal, neonatal, young adult, and elderly human spine, and the influence degenerative disc disease. Journal of Cell Science in Aging. (Manuscript submitted and under review). Christopher Duntsch, MD, PhD, Rano Chatterjee, MD, Zoran Pavecevic, MD, Zorica Janjetovic, MD, Mariya Nazarova, PhD, Qihong Zhou, MD, PhD, James Weimar, MD, PhD, Jeff Sorenson, MD, Erika Dillard, MD, PhD, Terreia Jones, PharmD, Umar Akbar, MD, Jon Robertson, MD (2014) Cancer stem cells can be isolated by expression of OCT4 and are critical determinants of tumorigenesis. Cancer Stem Cells. (Manuscript submitted and under review). Batson C, Hasegawa H, Zhou Q, Duntsch CD, Hallet M, Akbar U, and Pourmotabbed T. (2014) Anti-MMP-9 DNAzyme Arrests Glioma Tumor Progression in Immunocompetent Rodent Models of Glioma. Molecular Medicine. (Manuscript accepted with revision).



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APPENDIX BIO IACUC ANIMAL STUDY PROTOCOL APPLICATIONS AND RESEARCH IRB HUMAN TISSUE BIOBANKING APPLICATIONS AND RESEARCH PROGRAMS MEDICAL CREDENTIALING, LICENSURE, CONTINUING MEDICAL EDUCATION AREAS OF BASIC, TRANSLATIONAL, AND CLINICAL SCIENCE EXPERTISE MOLECULAR NEUROSURGERY RESEARCH PROGRAM SUGGESTED LIST OF REFERENCES



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BIO Over the last two decades, I have acquired significant expertise across selected core disciplines of life science: medicine, graduate sciences, academics, academic research, biotechnology, and commercial science. In each of these various cores, my productivity over time, and ability to balance the business of science with the challenges of research and development, are proof of concept of this expertise. My Education and Medical Training include: a Bachelors in Vertebrate Zoology; Doctorates in Medicine at the University of Tennessee Health Sciences Center (UTHSC) College of Medicine, and Philosophy (Stem Cell, Cell, and Molecular Biology) at the UTHSC Graduate Sciences Program and St. Jude Children’s Research Hospital (SJCRH) (Laboratory of James Ihle, PhD); General Surgery and Neurology Internships at the UTHSC General Surgery Program; Neurosurgery at the UTHSC Department of Neurosurgery; and a Neurosurgical Post-Clinical Fellowship at the UTHSC Neurosurgery Department and Semmes – Murphey Neurologic and Spine Institute. My Research Training and Experience include: an Undergraduate Senior Research Internship in Genetics; Graduate Research Internships in Hematology – Oncology (NIH Professional Oncology grant, SJCRH, Laboratory Jon Cunningham, MD), and Gene Therapy (UTHSC, Department of Urology, and Gene Therapeutics, Inc., Laboratories of Mitchell Steiner, MD); Doctorate research training in Philosophy (Stem Cell Biology, Cell and Molecular Biology) at St Jude Children’s Research Hospital, Department of Biochemistry (Laboratory of James Ihle, PhD); Post-doctoral Research Fellowships and training in Hematology – Oncology (SJCRH, Department of Biochemistry, Laboratory of James Ihle, PhD); Neuro-oncology (UTHSC, Department of Neurosurgery, Laboratory of Jon Robertson, MD), and Biomedical Engineering (UTHSC, Departments of Biomedical Engineering and Neurosurgery, Laboratories of Walleed Gaber, PhD, and Kevin Foley, MD). My Academic Experience (Collegiate and Research) at the University of Tennessee, College of Medicine, Department of Neurosurgery, includes: Faculty Appointment as Assistant Professor; Principle Investigator of a multi-lab biomedical research program; Molecular Neurosurgery Research Program - Program Director; Associate Program Director - University of Tennessee Cancer Institute’s Neuro-oncology Program; Professor of Graduate Studies and Teaching (Neuroscience, Neuro-oncology, and Molecular Biology) for the Colleges of Medicine, Pharmacy, and Graduate Health Sciences; Mentoring / Training of 20+ undergraduate, graduate, and postgraduate scientists in my labs. From 2002 to the present, I also acquired experience and expertise biotechnology and commercial science. In 2006 and 2007, I formally launched two stem cell based biotechnology companies from discoveries and developments in my academic research labs at the University (Novostem Therapeutics, Inc., 2006; Discgenics, Inc., 2007). These companies were founded in research programs for cancer stem cell biology drug discovery, adult stem cell biology, and regenerative medicine. For both companies (2006 – 2012), I served as the founder, President, Chief Science Officer, a Board Member, the Lead Scientist, and the Senior scientific author of all documents, IP, and applications. From 2008 – 2012, I served as the Medical Director and Tissue Bank Director of Nuvasive, Inc., (all US operations) for their commercial biologics program. I am the senior author and editor for over 900+ scientific and commercial science documents from academics, R&D, biotechnology, and business development. Over the last 20 years, I have received more than 20 awards in education, academics, medicine, and science. I am a member of 40+ national and international scientific organizations and groups, and I serve as an editor or reviewer for several academic journals and private research funding groups.



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IACUC ANIMAL STUDY PROTOCOL APPLICATIONS AND RESEARCH

PI of 70+ animal protocols for studies across three research institutions and several Biotechnology groups. Author of all IAUCUC protocols, trained all staff in all animal protocols as indicated, designed all animal models and molecular manipulations as the PI in all respects. Representative of the largest series of animal research through IACUC approved protocols likely in academics and commercial science. Decade series formed basis for translational research and strategy 100+ disease models and submodels Several Species Used, large and small animals 4000+ Animals 300+ Projects 7000+ Experiments Dozens of novel technologies created de novo for research 20 years of R&D, 7 Institutes, Universities, and Collaborating Biotechnology and Industry Groups 40+ scientists and staff involved with research

Neuro-Oncology IACUC 040212 – Xenograft of human glioma, Nude mice Thy 1 -/- for creating a side pocket tumor model IACUC 040212 – Xenograft of human glioma, Nude mice Thy 1 -/- for experimental therapeutics testing IACUC 25378 – Allogeneic brain cancer model with glioma cell lines F98, C6, and 9L sarcoma IACUC 25378 – Creation of an allogeneic brain cancer model biomarked with GFP, RFP, protein markers IACUC 25379 – Allogeneic brain meningioma models in immunocompetent and immunodeficient mice IACUC 253780 – A novel brain tumor resection model using molecular methods to biomark cancer cells IACUC 253780 – A novel brain tumor resection model to resect hemispheric tumor burden IACUC 253780 – A novel brain tumor resection model using high tech operative microscopic dissection IACUC 253780 – Red / green filter visualization, microneurosurgical technique, Neurointensive care

Neurologic Disease IACUC 67654 – Carotid artery flow restriction unilaterally to create hemispheric stroke IACUC 344315 – Use of biomechanic devices to create brain trauma in controlled environment. IACUC 34415 – Treatment of cranial neurotrauma with healthy adult neural stem cells derived from SVZ

Adult Neural Stem Biology IACUC 78764 – Implantation of normal adult neurospheres ~ biologic activity, growth, migration IACUC 78764 – Adult neurospheres to determine their effectiveness as anti-tumor agents / cell vectors IACUC 89765 – Neonatal mice and rat neurosphere generation from murine / rat GFP transgenic colonies

Experimental Therapeutics IACUC 040213 – Adeno-associated virus mediated IFN-B gene therapy to Nude mice Thy 1 -/- IACUC 78764 – Glioma adult neurospheres to monitor biologic activity, growth, migration in normal brain IACUC 78764 – Glioma adult neurospheres to determine their malignant properties de novo IACUC 78764 – Glioma adult neurospheres to determine their malignant properties with BRDU IACUC 78764 – Glioma adult neurospheres in vivo after resection or irradiation IACUC 67121 – Nude mouse tumor model for study of a novel Cannabinoid molecule, KM233 IACUC 67121 – Nude mouse tumor model for its anti-glioma and anti-cachetic effects over time. IACUC 67121 – Nude mouse tumor model for study of Cannabinoid molecules, dose / tumor load IACUC 234261 – Allogeneic brain cancer model with glioma cell lines F98, C6, and 9L sarcoma IACUC 234262 – Allogeneic brain cancer model, glioma cell lines, GFP or RFP marked IACUC 234263 – Allogeneic brain cancer model for tumor biology studies of healthy control animals IACUC 234263 – Allogeneic brain cancer model, treatment w/ dose-escalation, Vesicular Stomatitis Virus. IACUC 234263 – Allogeneic brain cancer model, treatment w/ dose-escalation, Vesicular Stomatitis Virus. IACUC 23426 – Allogeneic brain cancer model, tumor biology studies, DNAZyme oligonucleotides IACUC 23426 – Allogeneic brain cancer model for tumor biology studies, anti-RNA MMP9 DNAZymes IACUC 253780 – Microneurosurgical brain model to study BRDU loaded PGLA in the Tumor Cavity IACUC 253780 –The above study with dose escalation BRDU loaded PGLA in the Tumor Cavity IACUC 896751 – Adult brain model for study of the neuropoietic activity in the hippocampus, SVZ, RMS



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IACUC 896762 – The model of 89676, irradiation of the normal brain on the neural stem cell population IACUC 896763 – The model of 89676, irradiation of the normal brain on early / late progenitor population IACUC 896764 – The model of 89676, with irradiation of the terminal neural cell population IACUC 89001 – Adult brain model for study of the effect of BRDU at standard doses systemically IACUC 89002 – The model of 8900, +/- irradiation IACUC 89003 – The model of 8900 for study of tumor biology at the molecular, cellular, and tissue level IACUC 89014 – The model of 8900, used as the platform for testing therapies with the resection model IACUC 8902 – Adult brain model, study of drug delivery, microcranial catheter cranial (Alzet pump) IACUC 8903 – Adult brain model for multiple access over time for dosing in intervals IACUC 8904 – Adult brain model for delivery of molecular agents, convection flow for longer term dosing

Cancer Stem Cell Biology IACUC 90126 – Nude mouse tumor model for creation of a breast cancer xenograft model IACUC 90126 – Breast cancer stem cells (breast cancer cell line MB231), mammary fat pad IACUC 90126 – Monitoring for local / systemic spread of tumor, detection of rfp / gfp, CMV promoter IACUC 90127 – Nude mouse tumor model, breast cancer xenograft model by inoculating tumor IACUC 90126 – Breast cancer stem cells (breast cancer cell line MB231), mammary fat pad IACUC 90126 – Monitoring MB231 engineered to express Firefly / Renala luciferase, CMV promoter IACUC 90126 – Monitoring local and systemic spread of tumor, fluorescent detection of bioluminescence IACUC 90126 – Monitoring of the tumor biologics, MB231 cell line, normal mammary fat pad tissue / cells

NeuroSpine and Adult Disc Stem Cell Biology MERI PC 24320 – Extraction of disc material from healthy adult porcine and neonatal porcine animals MERI PC 24320 – Isolation, characterization, expansion of porcine nucleus pulposus stem cells MERI PC 24321 – Extraction of disc material from healthy adult porcine and neonatal porcine animals MERI PC 24321 – Extraction of disc material from healthy adult porcine and neonatal porcine animals IACUC 14595 – An adult rat spine surgery model for discectomy and laminectomy. IACUC 14596 – An adult rat spine surgery model for discectomy and laminectomy, PGLA toxicity studies IACUC 14597 – PGLA delivered Alizarin Red and Gallocyanine Blue Dye delivery to detect biodistribution IACUC 14597 – PGLA delivered Alizarin Red / Gallocyanine Blue Dye delivery, a pharamcologic model IACUC 14597 – PGLA delivered Marcane relevant dyes delivery to study structural / molecular data IACUC 14600 – Creation of foot pad thermal pain model of lower extremity sciatica IACUC 145981 – A rat spine surgery model for discectomy / laminectomy IACUC 145982 – The model of 14598, PGLA delivered dose escalated Marcaine IACUC 14599 – Intraoperative Marcaine delivery during spine surgery, epidural carrier Animal Research Training and Certification 1997 UTHSC Department of Veterinary Medicine 1999 SJCRH Animal Research Core 2009 Medical Education and Research Institute Details of Standard and Novel Animal Protocols, Techniques, Models Routine Animal Care, Protocols, Techniques: bedding, feeds, monitoring weight, maintaining day / night cycles and temperature cycles, watering, selection of filter tops, cage maintenance, working in isolation cabinets, working in isolation / quarantine sectors. DEA licensed for all types of medications and controlled substances and their appropriate administration in animal studies for pain control, surgical procedures, or as indicated for the surgical procedure performed. Intraperitoneal injections and sampling, suboccipital CSF sampling, tail vein injections in mice and rats, tail snips for genotyping, retro-orbital bleeds for blood sampling, tagging for identification, breeding and maintaining colonies, tissue harvest and preparation for all types of molecular assays and bio banking. Transgenic protocols for mice and rats using embryonic stem cells, knockout and knock-in protocols for mice and rats using embryonic stem cells, back breeding and husbandry of C57 / Black6 mice to create agoutis, and eventually -/- knockouts of a given targeted gene, bone marrow transplants and gene therapy of hematopoietic stem cells. Molecular approaches for imaging cancer and other disease states, systemically and cranially using genetic engineered cells with fluorescent reporters and operating microscopes with fluorescent filters.



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Healthy Neonate and Adult Species: Human, Murine, Rat, Porcine, Rabbit Genetic Strains and Transgenic Models: Nude Thy1 -/- Adult Mice and Rats C57 / Black 6 Mice for Transgenic RD JAK3 -/- Immunocompromised Mice GFP Transgenic Healthy and Nude Thy1 -/- Mice and Rats Animal Models for: Normal Brain Biology Epilepsy Brain Biology Carotid Clamp Models of Stroke Neurotrauma Models Systemic Cancer Models Pharmaceutical Science Models Small Animal Models of Glioma, Gliosarcoma, Glioblastoma, Metastatic Brain Cancer Sciatic Nerve Injury and Regeneration Studies in Rat Neural Stem Cell Hybridoma Modeling in Healthy Rats Nude mouse / rat Thy -/- side pocket and intracranial glioma Nude mouse / rat Thy -/- side pocket tumor models Nude mouse / rat Thy -/- Xenograft systemic breast cancer, prostate cancer, osteosarcoma, melanoma Immunocompetent Allograft mouse / rat systemic breast & prostate, osteosarcoma, melanoma Immunocompetent Allograft mouse / rat intracranial glioma and glioblastoma models Immunocompetent Allograft mouse / rat intracranial glioblastoma chemotherapy and radiation models Immunocompetent Allograft mouse / rat intracranial glioblastoma drug delivery models Immunocompetent Allograft mouse / rat intracranial glioblastoma neurosurgical resection models Multi Species Degenerative Spine Disease Multi Species Neural Stem Cell Biology Multi Species Adult Disc Stem Cell Biology Multi Species Cancer Stem Cell Biology Stem Cell Biology R&D In Vitro, In Vivo

ESCs, Cancer Stem Cells, Adipose Stem Cells, MSCs, NSCs, Chrondrocytic / Osteoblastic / Muscular / Melanocyte Stem Cells, Breast Stem Cells, Adult Disc Stem Cells, Notochordal Stem Cells, Trigerm and Bigerm and Early Single Ectodermal, Mesodermal, and Mesoderm OCT4 / NANOG +/- CD133 isolates.

Cancer stem cells and all aspects of platform culture biology and assays, in vitro and in vivo, and experimental therapeutics studies for over a dozen solid tumors, leukemias and lymphomas, and for primary cell cancer stem cells derived from human samples. Adult stem cell tissue engineering in solid organ disease models, animals models of benign and malignant brain tumor, animal models of genetic and induced acute and chronic myeloid and lymphoblastic leukemias, xenograft studies for oncology, cartilage and bone development, drug distribution and pharmacology.

Isolation, Culture, Assays, Quantification and Qualification, Biomarking, Proliferation, DNA content, Cell cycle analysis, MDR / ABC quantification and correlation with SP populations Experimental therapeutics for solid tumors: Novel, and known chemotherapeutics Atypical small molecules such as cannabinoids Viral therapeutics for both oncolytic and gene therapy delivery All aspects of drug pharmacology and formulation Lipid sphere delivery systems Osmotic pumps, subcutaneous pocket, convection-enhanced delivery over weeks and months (drugs, viruses, and novel / atypical anticancer agents, other small molecules)



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Oligo DNAzyme and RNAzyme anti glioma therapeutics PGLA / other biopolymers in vivo in the brain, spine, and subcutaneously as scaffolds or for drug delivery Delivery of drugs through intraperitoneal injection, tail vein injections in mice, carotid injections Brain glioma resection model Genetically engineered red and green fluorescent cancers, three fluorescent filter foot pedal operated surgical microscope (engineered by my lab) Safe, reproducible, tumor resection, without residual brain damage complicating the outcomes studies … True microneurosurgical technique combined with biomarkers and sensitive / specific technologies For near gross total resection without morbidity and mortality Standard post neurosurgical ICU conditions, monitoring, and medications Cranial and spinal surgery with application of experimental therapeutics and / or fusion biologics (adult rats, rabbits, and porcine models) Organotypic Brain Slice Culture, Brain Physiology, Ex Vivo Cancer Models, Tissue Engineering:

Physiologic brain slice bioscience & anatomical modeling (hippocampus, thalamus, and cortex systems)

Physiologic brain slice bioscience neuroelectrical modeling (hippocampus, thalamus, and cortex systems)

Organotypic Brain Slice Culture ex vivo model, for toxicity, safety, and pharmacology studies of potential neurotoxic cancer agents. An ex vivo glioma model was introduced into the system. Next all components were genetically engineered for improved analytics. 6 departments and two research institutes used the brain slice / glioma model as a gateway for entering small animal modeling (i.e., high throughput pharmaceutical drug screening platforms). In summary, a high yield realistic model of brain cancer for experimental therapeutic testing. (baseline pharmacology, Km50 toxicity studies, and dose escalation for toxicity and safety, end goal of glioma elimination, with brain tissue intact at the cell, tissue, organ levels anatomically, and further, the ability to monitor brain activity with electrophysiology monitoring technology.

A second generation tissue culture model using similar technology to that above for brain and cancer studies. Converted to rotating antigravity pressure spin tissue engineering culture system. This system was used to create and test tissue engineering biotechnology for adult disc stem cells discovered, as single cells grown on coated coverslips, as scaffolded 3D models, and as ex vivo disc with endplate models. A rat spinal decompression model (laminotomy and discectomy), for: Use with disc stem cell biologics, and for testing of PGLA biopolymer delivery systems for models Marcane and Buprenorphine slow release post-laminectomy to control back pain postoperatively. Bone fusion models were derived as well. Many of the above disease models were also done in rabbits, piglets, adult pigs, goat and sheep, and canine, as indicated. Cranial and spinal surgery with application of experimental therapeutics and / or fusion biologics (only or interbody) in adult rats, rabbits, and porcine models.



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HUMAN IRB PROTOCOLS, STUDIES, BIOBANKING Principal Investigator on all IRB studies and Tissue Biobanking Programs: 200+ subsequent projects 2-3000+ subsequent experiments IRB studies were done at: Methodist University Hospital Baptist Central and Baptist Collierville Hospitals University of Tennessee Hospitals Lebonheur Children’s Hospital St Jude Children’s Research Hospital. Novostem Therapeutics, Inc. Discgenics, Inc. UT Cancer Institute IRB studies represent: Diverse types of tissue, and organs Diverse ethnicities, ages (adult and pediatric), gender Normal Tissue Cell and Molecular Biology Diverse types of Disease Neurological Diseases Represented: Pediatric and Adult Brain Cancer Pediatric and Adult Epilepsy Pediatric and Adult Degenerative Diseases Pediatric and Adult Neuro-trauma Pediatric and Adult Autoimmune diseases Adult Neurovascular Disease Study Variables: 8 Years of IRB studies 9 Institutions or Collaborating Biotechnology Groups 8000 cell, tissue, and organ specimens collected 15000 tissues processed for cells and cell biomaterials, for cell and molecular Biology R&D

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IRB Study MNRP1 - Methodist University Hospital; Memphis, Tennessee Collection of Adult Human Brain Tumors for Molecular Biology / Genomic Assays Co-investigator: Dr. Jon Robertson, Dr. Madison Michael, Dr. Allen Sills, Dr. Rick Boop, Dr. Jeff Sorenson IRB Study MNRP2 - Baptist Hospital; Memphis, Tennessee Collection of Adult Human Brain Tumors for Molecular, Biology and Genomic Assays Co-investigator: Dr. Jon Robertson, Dr. Bruce Frankel, Dr. Jeff Sorenson IRB Study MNRP3 - Le Bonheur Children’s Hospital; Memphis, Tennessee Collection of Pediatric Brain Tumors – Molecular Biology / Genomic Assays Co-Investigator: Dr. Rick Boop, Dr. Michael Muhlbaher IRB Study MNRP4 - Methodist University Hospital; Memphis, Tennessee, Collection of Adult Human Brain Tissue Resected en bloc for Epilepsy for Molecular Biology and Genomic Assays, Co-Investigator: Dr. Rick Boop, Dr. Madison Michael, Dr. Allen Sills, Dr. Jon Robertson. IRB Study MNRP5 - Le Bonheur Children’s Hospital; Memphis, Tennessee Collection of Pediatric Human Brain Tissue Resected en bloc for Epilepsy



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Molecular Biology and Genomic Assays Co-investigator: Dr. Rick Boop IRB Study MNRP6 - Methodist University Hospital; Memphis, Tennessee Collection of Adult Spinal Disc (nucleus and annulus) at the time of surgery Molecular Biology & Stem Cell Biology Co-investigator: Dr. Madison Michael, Dr. Allen Sills, Dr. Rick Boop, Dr. Jeff Sorenson, Dr. Jon Robertson IRB Study MNRP7 - Baptist Hospital; Memphis, Tennessee Collection of Adult Spinal Disc (nucleus and annulus) at the time of surgery Molecular Biology & Stem Cell Biology Principal Investigator: Dr. Kevin Foley



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MEDICAL CREDENTIALING, LICENSURE, CONTINUING MEDICAL EDUCATION Current/ Past Hospital Accreditations – Dallas, TX and Memphis, TN Baylor-Plano Regional Medical Center Minimally Invasive Spine Institute Forrest Park Medical Center Texas Regional Medical Center at Sunnyvale SHC Community Hospital Surgery Center at Legacy, University General The Methodist University Hospital Baptist Memorial Hospital – Memphis Baptist Memorial Hospital – Collierville The Semmes-Murphey Neurologic and Spine Institute The Regional Medical Trauma and Shelby County Hospital Le Bonheur Children’s Hospital Medical Licensure The State of Texas 2011 N6861 The State of Tennessee 2009 MD0000045161 Rx Regulatory Licenses DEA, Clinical DEA, Animal Research Continuing Medical Education Graduate Neurosurgical – 300+ hours Practice – Voluntary, Neurosurgical Courses – 38 hours Ongoing – Texas A+M Faculty Mentor Group



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AREAS OF BASIC, TRANSLATIONAL, AND CLINICAL SCIENCE EXPERTISE Basic Science, Translational Science Biology: Cell Biology, Molecular Biology, Physiology, Biochemistry, Biophysics Bioscience Subspecialized Areas: Cancer Biology, Neuroscience, Immunobiology, Stem Cell Biology Tissue Models of Expertise: Intervertebral Disc, Degenerative Disc Disease, Cartilage Biology, Neural Tissue Biology, Bone Marrow Biology Tertiary Bioscience: Biomarkers, Biomathematics, Biomimetics, Biostatistics Applied Bioscience: Decision Theory, Lattice Field Theory, Vertex Model, Biosystems Engineering Cell Biology Tissue Culture, Primary Tissue Culture, Tissue / Cell Culture Assays, Passaging, MTS/MTT assays Cell and Molecular Imaging: Electron and Confocal Microscopy, Light Microscopy, Inverted Microscopy, Molecular Biology DNA Molecular Assays: Sequencing, Cloning, Subcloning, Genomics RNA Molecular Assays: PCR, SQ and RT-PCR, Real Time PCR, Northern, In Situ Hybridization Protein Assays: Westerns, FACS analysis and Sorting, Gel Shift Assays, Immunohistochemistry, Elisa Special Topics: Biomarkers, Biomathematics, Nanotechnology, Signal Transduction, Cell Cycle, Cell Membrane and Adhesion Biology, Cytoskeleton, Cytokine Signaling, ECM Biology Genomics Microarray, SNP Genomics, Bioinformatics, Epigenetics, Pharmacogenomics, Proteomics, Functional Genomics, Computer Science, Computer Algorithms, Phenotype-Genotype Linkage Biobanking and Patient Registries Biomechanical Engineering Biomechanics, Spinal Biomechanics, Spinal Instrumentation Biomedical Engineering Biomedical Devices, Biologic Devices, Biomedical R&D Genetic Engineering Transient and stable transfections with antibiotic selection Retroviral Transduction Transgenics, Gene knockouts and knock-ins Inducible Expression Systems Cancer Cell Biology Neuro-oncology, Hematology – Oncology, Breast Cancer, Osteosarcoma Prostate Cancer, Melanoma, Myeloma and Leukemia, Lung Adenocarcinoma Primary, Recurrent, Radiation and Chemotherapeutic Rx Oncogenesis, Transformation, Tumor Suppressor Genes Apoptosis, Cell Motility and Migration, Oncogenes Metastatic Biology ECM biology – matrix, enzymes, signaling Cancer Stem Cell Biology Embryonic Stem Cell Biology Adult Stem Cell Biology Stem Cell Modeling and Protocols Stem Cell Culture Assays, Differentiation Assays, Passaging Sphere Culture, SP assays Immunobiology and Immunopriviliged Biology of Cancer Stem Cells



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Drug screening, Drug Discovery, Drug Development Stem Cell Biology Embryonic Stem Cell Biology Induced Pluripotent Stem Cell Biology Adult Stem Cell Biology Stem Cell Modeling and Protocols Stem Cell Culture Assays, Differentiation Assays, Passaging Sphere Culture, SP assays Immunobiology and Immunopriviliged Biology in Stem Cells Drug screening, Drug Discovery, Drug Development Neural Stem Cells, Mesenchymal Stem Cells, Chrondrocytic Stem Cells, Osteocyte Stem Cells, Hematopoietic Stem Cells Notochordal Stem cells

Translational Research Animal Models of Disease, Molecular Tools in Animal Models, Intracranial Microsurgery, Xenograft and Allograft Models, Small Animal Spine Disease Modeling, Paraspinal Narcotic / Antibiotic Delivery, Amnion Biologics & Applications / Bioproducts, Fusion Biology, Developmental Biology: Spinal Development (Disc, Bone) Therapeutics and Treatment Strategies: Experimental Therapeutics, Pharmaceutical Science, Drug Discovery, Drug Development, Drug Delivery Systems, CNS Convection Enhanced Delivery, DNAZyme and RNAzyme Rx, VSV Viral Cytolytics, AAV gene therapy with IFNB, Cannabinoid Chemotherapeutics, Polymer Drug Delivery / Rx Tissue Engineering 2D, 3D, 4D Tissue Engineering, Burst Kinetic Tissue Engineering Organotypic / Tissue Engineering, Ex Vivo Tissue Engineering, Cells, Stem Cells, Synthesis, Tissue Culture, Scaffold Biology, Matrix Biology, Silk Scaffolding, Polymer Science, Fluid Dynamics, Copolymerization, Fabrication, Bioreactors and Tissue Reactors, Regenerative Medicine Clinical Science Clinical Trials, Biobanking, Patient Registries, Primary Tissue Cultures



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Pain Management, Biopsychosocial Modeling Cranial Neurosurgery, Hydrocephalus, Functional Neurosurgery, Neurocritical Care, Traumatic Brain Injury, Neuro-oncology Tumor resection from the CNS Spinal Cord Surgery, Spinal Cord Injury, Spinal Cord Decompression, Spinal Fusion Mechanical Back Pain, Radiculopathy, Neuromodulation Complex, General Spine Surgery Minimally Invasive Spine Surgery Biotechnology Business Models Operations Strategic Planning, Market Development, Commercialization, Innovative Modeling, Fundraising, SEC and Regulation Public Speaking for Fundraising, Marketing Biotechnology R&D: Discovery Science, Biologic Applications, Bioproducts Small Molecule Therapies, Platform Biotechnologies, FDA regulatory Biobanking: Adult stem cells Umbilical and Cord Blood GMP CMO, CRO, SRO Collaborations and Contracts Intellectual Property Areas of Expertise Identifying IP Inventorship Authorship Ownership Developmental R&D Commercial R&D Patent Writing and Strategy, Patent Maintenance and Defense Patent Office Actions and Issuance USPTO and WPTO Legal and Regulatory Guidelines



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Scientific Writing and Editing Scientific Manuscripts Scientific Abstracts Scientific Books and Book Chapters Scientific Program Scientific Reports Grant Writing and Strategy Human IRB Protocols IACUC Animal Protocols Academic Areas of Expertise Program Development Project Design Experimental Design Design Control Strategic Collaborations Cell and Molecular Biology Animal Models for R&D Translational Research Clinical and Basic Science Presentations Teaching of Medical and Graduate Studies Academic Research and the Scientific Method Academic Grant Writing and Strategy Alternative Funding Mechanisms Mentoring and Training Young Scientists Publishing of Research in Peer Review Journals Endorsements: Education, Academics, Research, Scientific Writing, Biotechnology, Bioconsulting* 45Neuroscience 38Molecular Biology 34Biotechnology 27Cell Biology 24Stem Cell Biology 22Clinical Research 17Biomedical Engineering 12Spine 11Biochemistry 11Neurosurgery 10Education and Graduate Teaching 10Scientific Writing 10Medical Devices 9PCR 9Cancer Biology 8Mentoring 8Molecular Imaging 8FDA 7Apoptosis 7Biomedical Sciences 7Intellectual Property and Patent Strategy for Life Sciences 6Tissue Engineering 6Academics 6Medical Technology 6Cell Differentiation 6Medicine 6Neurology 6Cell Molecular Biochemical Techniques 5Spine Surgery 5Minimally Invasive Spine Surgery 5Genetic Engineering 5Neuroanatomy 5Immunology 4Strategic Planning 4Drug Discovery 4Brain Injury 4Animal Modeling 4Computational Molecular Biology 4Genetics 4Cell Culture 4Glioma 4Stereotactic Radiosurgery 4Journal Impact Factor 4Cells 4Biomedical Devices 4Spine Research 4Scientific Writing 4Regenerative Medicine 4Biomedical Applications 4Immunohistochemistry Genomics, Bioinformatics, Biostatistics, 4 Drug Discovery and Development 4Bioscience 3Embryonic Stem Cell Biology 3Stereotactic Surgery 3Brain Tumors 3Matrix Biology 3Intervertebral Disc Arthroplasty 3Neurostimulation 3Cartilage 3Adult Stem Cell Biology 3Migraine 3Lattice Field Theory 3Medical Neurosciences 3Neuronavigation 3Cell Proliferation 3Microscopy 3Neuro-Oncology 3Bone 3Hydrocephalus 3Flow Cytometry 3Mesenchymal Stem Cell Biology 3Intervertebral Disk Degeneration 3Pain Medicine 3Traumatic Brain Injury 3Intervertebral Disk Biology 3Functional Neurosurgery 3Spinal Surgery 3Spinal Cord Injury 3Molecular Systems Biology 3Search Engine Optimization 3Translational Science 3Subcloning 3Surgery 3Biomechanics 3Decision Theory 3Cloning and Subcloning 3Cloud Computing 3Back and Pelvic Pain 3Biomathematics 3In Situ Hybridization 3Corporate Biotechnology 3Basic Science 3Spinal Cord 3Expertise in Minimally Invasive Spine Surgery 3Clinical Science 3Spinal Instrumentation 3Vertex model 3Microbial Molecular Biology 3Research Program Building 3Academic Scientific Productivity of all Kinds 3Back Pain 3Mentoring and Training in Medicine and Science 3Building Research Groups 3Morphologic Analysis / Problem Solving 3Biotechnology Startup and Early Development 3 R&D Operations 3Applied Bioscience 3Tumor Biology 3Decision Field Theory 3Research Peer Review 3Computational Chemistry 3Spinal Biomechanics 3Molecular Membrane Biology 3Bio-applied Computer Engineering 3Networks in



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Molecular Biology 3Stem Cell Culture Technique 3Biomaterials 3Neurosurgical Procedures 3Metastasis 3Bone Research 3Bone Marrow Cells 2Translational Science 2Genome Based Biomarking 2Cranial Neurosurgery 2Molecular Models of Disease in Animals 2scaling limit 2medicolegal 2Corner Transfer Matrix 2Genetics 2Flow Cytometry 2Neuroscience 2Basic and Complex Biostatistics 2Stroke 2Brain Computer Interface Technology 2Neuromodulation 2Bioweb Design and Media 2Pediatric Neurosurgery 2Biomarkers 2Innovative Modeling 2Silk Biochemistry 2Biopsychosocial Modeling 2Bioinformatics 2Public and Private Grant Writing (also 2S – Duality, Genomics, Clinical Development, Market Development, Bioinformatics, Pain Management, Tissue and Cell Culture Biology, Commercialization, Clinical Research, Clinical Trials, Medicine, Life Sciences, Regenerative Medicine, RNA, DNA, Protein Biochemistry, Immunohistochemistry, In Vitro Modeling, In Vivo Modeling, Translational Medicine, Intellectual Property and Patent Writing, Maintenance, and Defense, Matrix Biologics, Fluid Dynamics, Biomechanical Engineering, Pharmacobiology, Pharmacogenomics Biomarkers, Discovery Science, Biomathematics) *Endorsements from leaders in academics and commercial science in various venues. The number of separate endorsements for a given area is followed by the endorsed area.



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MOLECULAR NEUROSURGERY RESEARCH PROGRAM (MNRP) The MNRP is a formal research group with a shared set of goals and objectives that evolved from the research program at the UTHSC Department of Neurosurgery (2001 – 2005). The MNRP is the founding research group and the center of a Network of Universities, Institutes, Biotechnology groups, Foundations, Consultants, and SROs. Program Director – Christopher Duntsch, MD, PhD All scientific faculty and officers considered co-directors or members of the MNRP meet the following Academic criteria (labeled below with an *): 1 Senior scientist and faculty, expert in respective discipline, interests in MNRP RD target 2 > 4 years as primary collaborating entity with the MNRP (most > 10 years) 3 Contributed significant time and resources to MNRP collaborations and projects 4 Co-directed all research, and committed their faculty, students, and staff to all projects 5 Submitted academic abstracts and presentations from MNRP research per standard routines 6 Co-authored and published academic publications from MNRP research per standard routines. 7 Co-authored grants and funding requests for MNRP projects in collaboration per standard routines UNIVERSITIES (AND SUBDISCIPLINES)

University Of Tennessee Health Science Center Neurosurgery Molecular Neurosurgery Research Program Molecular Sciences Virology Biomedical Engineering Pharmacy Pharmaceutical Sciences Pharmacology Neurobiology

University Of Memphis Genomics Bioinformatics INSTITUTES (AND SUBDISCIPLINES)

St Jude Children’s Research Hospital Pediatric Oncology and Surgery Radiation Oncology Cancer Biology

Medical Education and Research Institute

Semmes – Murphey Neurologic and Spine Group Neurosurgery Neuro-oncology Biomedical Engineering Connective Tissue Disease Spinal Biologics BIOTECHNOLOGY GROUPS (AND SUBDISCIPLINES)

Gene Therapeutics, Inc. Viral Cytolytics Gene Therapy

Genome Explorations, Inc.



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Genomics Bioinformatics Biostatistics

Discgenics, Inc. Adult Disc Stem Cell Biologics Matrix Biology Tissue Engineering Regenerative Medicine Platform Biotechnologies

Novostem Therapeutics, Inc. Cancer Stem Cell Biology Drug Discovery Drug Development Platform Biotechnologies Pharmaceutical Sciences PRINCIPLE INVESTIGATORS, RESEARCH SCIENTISTS, COLLABORATING SCIENTISTS (students, medical residents, technical support staff)

UTHSC – College of Medicine – Department of Neurosurgery (Clinical) (clinical arm of the MNRP) Rick Boop, MD (Chairman, Professor) Jon Robertson, MD (Former Chairman, Professor) Robert Sanford, MD (Professor) Kevin Foley, MD (Professor) Julius Fernandez, MD (Assistant Professor) Bruce Frankel, MD (Assistant Professor) Madison Michael, MD (Assistant Professor) Jeff Sorenson, MD (Assistant Professor) Christopher Duntsch, MD, PhD (Assistant Professor) Michael Taylor, MD, PhD (Surgical resident) Jay Weimar MD, PhD (Surgical resident) Jon Winestone, MD (Surgical resident)

UTHSC – College of Medicine – Molecular Neurosurgery (Academic Research) Christopher Duntsch, MD, PhD (Assistant Professor)* Valery Kukekov, Phd (Professor) Tanya Ignatova, PhD (Associate Professor) Qihong Zhou, MD, PhD (Assistant Professor) Zixiu Zhang, PhD(Assistant Professor) Silva Hanissian, PhD (Assistant Professor) Dwight Bordelon, PhD (Graduate Student) Zoran Pavecevic, MD (Postdoctoral Scientist) Rano Chatterjee, MD (Postdoctoral Scientist) Kenichiro Asano, MD, PhD (Postdoctoral Scientist Bing Teng, MD (Senior Technician) Gala Dulatova, PhD (Senior Technician) Mariya Nazarova, PhD (Senior Technician) Xiofie Wang, MD (Senior Technician) Raisa Krutilina, PhD (Postdoctoral Scientist) Jay Weimar MD, PhD (Surgical resident)

UTHSC – College of Pharmacy



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George Wood, PhD (Professor)* Terriea Jones, PharmD (Assistant Professor)* Divi Murali, PhD (Graduate Student) Joe Barnes (Senior Technician)

UTHSC – Neurobiology Steve Kitai, PhD (Professor)* Xixiu Zhangh, PhD (Assistant Professor)*

UTHSC – Pharmaceutical Sciences and Pharmacology Steven Gurley, PhD (Professor)* Atul Shukla, PhD (Professor)* Bob Moore, PhD (Assistant Professor)* Sun Yin, PhD (Assistant Professor)* Yichun Sun, PhD (Assistant Professor)* Jason Denbo, MD (Surgical resident) Christy Wilson (Graduate student)

UTHSC - Biomedical Engineering Walleed Gaber, PhD (Professor)* HR Menk, MD (Assistant Professor)* Che Yeng, PhD (Assistant Professor) Regan Williams, MD (Surgical resident) Thomas Sims, MD (Surgical resident)

UTHSC - Molecular Sciences Lawrence Pfeffer, PhD (Professor)* Michael Whitt, PhD (Professor)* Tayebah Pourmotabbed, PhD (Professor)* Yichun Sun, PhD (Assistant Professor)* Erika Dillard, MD, PhD (Graduate Student) Himangi Jayakar, PhD (Postdoctoral Scientist) Chad Batson MD, PhD (Graduate Student)

St Jude Children’s Research Hospital

Pediatric Oncology Andy Davidoff, MD (Professor)*

Radiation Biology Tom Merchant, MD, PhD (Professor)*

Medical Education and Research Institution Kevin Foley, MD (Medical Director) Christopher Duntsch (Translational Science Director)

Semmes – Murphey Neurologic and Spine Group Kevin Foley, MD (Clinical Director) John Robertson, MD (Clinical Scientist) Rick Boop, MD (Clinical Scientist) Jeff Sorenson, MD (Assistant Professor) Novostem Therapeutics, Inc. Christopher Duntsch, MD, PhD (President, CSO, Board)* Tatyana Ignatova, PhD (Senior Research Officer)* Valery Kukekov, PhD (Senior Research Officer)* Umar Akbar, MD (Senior Research Officer)* Rano Chatterjee, MD (Senior Research Officer)

Discgenics, Inc.,



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Christopher Duntsch, MD, PhD (President, CSO, Board)* Umar Akbar, MD (Senior Research Officer)* Valery Kukekov, PhD (Research Officer) Galina Dulatova, MD (Research Officer)

Hybrid Bioscience, Inc. Christopher Duntsch, MD, PhD (President, CSO, Board)*

Gene Therapeutics, Inc. Mitch Steiner, MD (Founder, CEO)* Mike Whitt, PhD (Director of Virolytics)* Himangi Jayakar, PhD (Senior Research Officer) Christopher Duntsch, MD, PhD (NSR RD liaison)

Genome Explorations, Inc. Divian Patel, MD (Founder, CEO)* Christopher Duntsch, MD, PhD (NSR RD liaison) Business Development Group Mike Moffat, Corporate Accounting, Financial Strategies Collin Childress, Business Development Paul Cleckner, Business Professional

Legal Counsel Mark Cohen – Life Sciences Intellectual Property Collin Childress – Business and Corporate Law

IT and Internet / Web Management TJ Johnson (Organnix, Inc.)



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SUGGESTED LIST OF REFERENCES Research and Development Tayebah Pourmotabbed, PhD (Professor, UTHSC, Molecular Sciences) Walleed Gaber, PhD (Professor, UTHSC, Biomedical Engineering) George Wood, PhD (Chairman, Professor, UTHSC, Pharmaceutical Sciences) Terriea Jones, PharmD (Assistant Professor, UTHSC, Pharmaceutical Sciences) Steve Kitai, PhD (Chairman, Professor, UTHSC, Neurobiology) Atul Shukla, PhD (Professor, UTHSC, Pharmacology) Bob Moore, PhD (Assistant Professor, Pharmaceutical Science) Sun Yin, PhD (Assistant Professor, UTHSC, Pharmacology) Yichun Sun, PhD (Assistant Professor, UTHSC, Pharmacology) Michael Whitt, PhD (Professor, UTHSC, Molecular Sciences) Hershel Wall, MD (Professor, University of Tennessee Chancellor, UTHSC Memphis) Academics - Graduate Education, Mentoring and Training, and Teaching William Pulsinelli, MD (Professor, Chairman, UTHSC, Neurology) Hershel Wall, MD (Professor, University of Tennessee Chancellor, UTHSC Memphis) Umar Akbar, M.D Rano Chatterjee, MD Erika Dillard, M.D., PhD Divi Murali, PhD Kenichiro Asano, M.D., PhD. Andrew Hanover, MD Biotechnology University of Tennessee Research Foundation Technology Transfer Group Paul Cleckner, Business Professional (CEO, Novostem) Mitch Steiner, MD (CEO, Gene Therapeutics, Inc., Professor and Chairman, UTHSC Urology) Mike Moffat CPA, Corporate Accounting, Financial Strategies (CFO, Novostem, Discgenics) Collin Childress, JDA, MBA (Corporate & Business Legal, Novostem & Discgenics) Divian Patel, MD (CEO, Genome-Explorations) Commercial Science and Industry Bryan Cornwall , PhD (VP of R&D for Nuvasive, Inc.) Mitch Steiner, MD (CEO, Gene Therapeutics, Inc., Professor and Chairman, UTHSC Urology) Mike Moffat, CPA (CFO for Discgenics, Novostem) Collin Childress, JDA, MBA (for Discgenics, Novostem)



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