CYNTHIA CZAJKOWSKI, Ph.D.
University of Wisconsin – Madison
Department of Neuroscience
1111 Highland Drive
Madison, WI 53711
(608) 265-5863 (Office); (608) 265-7821 (FAX)
EDUCATION
1987 State University of New York, Health Science Center at Brooklyn
Ph.D., Anatomy and Cell Biology; Thesis advisor: Dr. David H. Farb
Thesis title: “Transmembrane topology, subcellular distribution and turnover of
the GABAA/benzodiazepine receptor in chick brain cell culture.”
1979 New York University
B.A., Biology (Dean’s List)
PROFESSIONAL POSITIONS
2011 – pres Professor, University of Wisconsin-Madison, Dept. of Neuroscience
2005 – 2011 Professor, University of Wisconsin-Madison, Dept. of Physiology
2005 – 2006 Interim Chair, Neuroscience Training Program, University of Wisconsin
2000 - 2005 Associate Professor, University of Wisconsin-Madison, Dept. of
Physiology
1994 - 2000 Assistant Professor, University of Wisconsin-Madison, Dept. of
Physiology
1992 - 1994 Associate Research Scientist, Columbia University, Center for Molecular
Recognition, Dept. of Biochemistry and Molecular Biophysics
1987 - 1992 Postdoctoral Research Scientist in the laboratory of Dr. Arthur Karlin,
Columbia University, Dept. of Biochemistry and Molecular Biophysics
HONORS
2012 UW- Vilas Distinguished Achievement Professor
2008 Dr. Brenda Pfaehler Award of Excellence, TRIO program for mentoring
undergraduate students from underrepresented backgrounds
2004 College de France: Distinguished Lecturer
2001 The National Alliance for Research on Schizophrenia and Depression,
Independent Investigator Award
1996 Burroughs Wellcome Fund, New Investigator Award
1996 Basil O’Connor Starter Scholar, March of Dimes Foundation
1989 - 1991 NSRA Training Fellowship, Columbia University
1985 - 1987 Predoctoral graduate research fellowship, SUNY, Health Science Ctr. at
Brooklyn
1986 Sigma Xi, Scientific Research Society
1975 - 1979 New York University, Four-Year Scholastic Scholarship
1975 New York State Regent’s Scholarship (declined)
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PROFESSIONAL SOCIETIES
American Society for Pharmacology and Experimental Therapeutics (ASPET)
Biophysical Society
Society of Neuroscience
TEACHING ACTIVITIES - CLASSROOM
2016 Instructor, Chemistry 872, Topics in Biophysics, (predoctoral instruction)
U. of Wisconsin-Madison
2010 - 2014 Course Director, Cell and Molecular Neuroscience 610, (predoctoral
instruction) Dept. of Physiology, U. of Wisconsin-Madison
2001 - pres Instructor, Neuroscience 675, Undergraduate neurobiology seminar
1997 - 2014 Instructor, Cell and Molecular Neuroscience 610, (predoctoral instruction)
Dept. of Physiology, U. of Wisconsin-Madison
1995 - 2011 Instructor, Biochemical Pharmacology711: Neurotransmitter
Receptor/Ion Channels (predoctoral instruction) Dept. of Pharmacology,
U. of Wisconsin-Madison
1997 - pres Instructor, Professional Development Course (predoctoral instruction)
Neuroscience Training Program, U. of Wisconsin-Madison
2011 Instructor, Chemistry 872, Topics in Biophysics, U. of Wisconsin-
Madison
Spring 2010 Seminar Moderator, Neuroscience 990,Topics in Neuroscience,
(predoctoral instruction) Neuroscience Training Program, U. of
Wisconsin-Madison
2007 Instructor, Neurobiology 500, undergraduate seminar series
2005 Instructor, Neurobiology 500, undergraduate seminar series
2004 Instructor, Neuroscience 990, Neuroscience –Channelopathy subgroup
2001 - 2008 Instructor (small groups), Medical Physiology 711 (medical student
instruction) Dept. of Physiology, U. of Wisconsin-Madison
1995 - 1997 Instructor, Medical Neurosciences, (medical student instruction) Dept. of
Neurophysiology, U. of Wisconsin-Madison
Fall 1996 Seminar Moderator, Topics in Neuroscience, (predoctoral instruction)
Neuroscience Training Program, U. of Wisconsin-Madison
1991 - 1993 Lecturer, Neurobiology of Disease course for PGY2 psychiatry residents,
Columbia University, NY, NY
1987 - 1989 Instructor, Neurobiology summer course, Marine Biological Laboratories,
Woods Hole, MA
1980 - 1983 Graduate Teaching Assistant, Neuroscience and Gross Anatomy courses
SUNY, Health Science Center at Brooklyn, College of Medicine
1978 - 1979 Laboratory Instructor, Biology, Chemistry and Physics, Elizabeth Irwin
High School, NY, NY
TEACHING ACTIVITIES - MENTORING
Postdoctoral Trainees:
2014 - pres Namrta Purwar, Postdoctoral Research Fellow
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2011 – 2016 Cassie Theusch, Postdoctoral Scientist (Honors: Biophysical Society
Travel Award 2015, Papers: primary author 2 papers in preparation,
Currently - Instructor, Life Sciences, University of Arkansas
2008 – 2013 Cosma Dellisanti, Postdoctoral Research Fellow (Papers: primary author
two papers. Currently: Assistant Editor: Nature Molecular and Structural
Biology)
2011 – 2012 Kurt Laha, Postdoctoral Research Fellow (Papers: primary author one
paper. Currently: Scientific Proposal Leader, Catalent Pharma Solutions,
Madison, Wisconsin.
2006 – 2009 Susan Hanson, Postdoctoral Trainee, Dept. of Physiology, U. of
Wisconsin (Honors: Awarded individual postdoctoral NRSA from NIH,
awarded Society for Neuroscience Travel Award, 2007; Papers: primary
author three papers, co-author one paper, 3 abstracts) Currently: Asst.
Professor Lecturer, Carroll University, Waukesha, WI
2005- 2006 Spencer Ericksen, Postdoctoral Trainee, Dept. of Physiology, U. of
Wisconsin (Papers: co-author two papers) Currently: Assistant Scientist -
Small Molecule Screening Facility, Carbonne Cancer Center, University
of Wisconsin - Madison.
2005- 2006 Leonardo Hernandez Hernandez, Postdoctoral Trainee, Dept. of
Physiology, U. of Wisconsin. Currently: Profesor Tiempo Completo
Titular "A" at Universidad de Guadalajara, CUCS, Mexico
2001 - 2003 Glen Newell, Postdoctoral Trainee, Dept. of Physiology, U. of Wisconsin
(Honors: Awarded postdoctoral NSERC fellowship from Canada; Papers:
primary author of three papers, 1 review article, 2 abstracts) Currently:
Associate Director Clinical Pharmacology, Biovail Contract Research
Ontario, Canada
1997 - 2001 David Wagner, Postdoctoral Trainee, Dept. of Physiology, U. of
Wisconsin (Honors: Awarded individual postdoctoral NRSA from NIH;
Papers: primary author one paper, coauthor three papers, 5 abstracts)
Previous: Assistant Professor at Marquette University, Currently:
unknown
1994 - 1997 Andrew Boileau, Postdoctoral Trainee, Dept. of Neurophysiology, U. of
Wisconsin (Papers: primary author 3 papers, coauthor of 2 papers, 7
abstracts) Currently: Assoc. Prof. and Director of Neuroscience, Saba
University of Medicine, Netherlands Antilles,
1994 - 1996 Nicholas Cozzi, Postdoctoral Trainee, Dept. of Neurophysiology, U. of
Wisconsin-Madison. Currently: Associate Scientist and Lecturer, Cell &
Regenerative Biology Department, School of Medicine & Public Health,
University of Wisconsin – Madison (Papers: 1 abstract)
Predoctoral Student Trainees:
2015 - pres Jennifer Borchardt, Cell and Molecular Biology
2013 - pres Tzu-Wei (Vicki) Tsao, Physiology Graduate Training Program (Papers:
primary author one paper in preparation, 2 abstracts)
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2013 - pres Varun Tiwari, Biophysics Training Program (Honors: Biophysical
Society Travel Award, 2016; Papers: primary author 1 paper in
preparation, 2 abstracts)
2009 - 2014 Borna Ghosh, Biophysics Training Program (Awarded Ph.D. Honors:
Biophysical Society Travel Award, 2013; Papers: primary author 1 paper,
co-author 2 papers, 4 abstracts, primary author 1 paper in preparation;
Currently: post-doc in lab of Chris Lingle at Washington University, St.
Louis)
2008 - 2012 Elaine Morlock, Molecular and Cellular Pharmacology Program (Awarded
Ph.D. Honors: awarded individual predoctoral NIH-NRSA, Vilas travel
award, Papers: primary author 1 paper, co-author 1 paper, 2 abstracts,
Currently: Patent agent at Mintz Levin Law Firm, San Francisco, CA,
admitted to law school)
2009 - 2011 Valerie Grant, Neuroscience Training Program (Awarded M.S. Papers:
coauthor one paper. Honors: awarded individual NSF predoctoral
fellowship, Currently in Med. School)
2005 - 2011 Kelly Christopherson, Molecular and Cellular Pharmacology Program.
(Awarded Ph.D. Honors: awarded individual predoctoral NIH-NRSA,
awarded Vilas 2008 Travel Grant, Papers: Primary author 1 paper, co-
author 1 paper, 2 abstracts) Currently: stay at home Mom when husband
took position at Astrazeneca in England
2004 - 2010 Cassandra Theusch, Cell and Molecular Biology Training Program
(Awarded Ph.D., Papers: co-author 1 paper, primary author of 4 abstracts)
Currently, Instructor, Life Sciences, University of Arkansas.
2004 - 2008 Srinivasan Venkatachalan, Physiology Training Program (Awarded Ph.D.
Papers: primary author 2 papers, 5 abstracts; Honors: Awarded Society for
Neuroscience Travel Award, 2007; Biophysical Society Travel Award,
2008, FASEB Travel Award, 2008) Currently, Senior Research Scientist,
Cromocell Corporation, New Jersey.
2003 - 2007 Jose Mercado, Neuroscience Training Program (Awarded Ph.D. Papers:
primary author of 2 papers, 2 abstracts; Honors: Awarded Predoctoral
Fellowship from American Psychological Society, Biophysical Society
Travel Award) Currently, Scientist at Kineta Inc. Seattle, Washington.
2002 - 2006 Feyza Sancar, Neuroscience Training Program (Awarded Ph.D. Papers:
primary author of 3 papers, 2 abstracts; Honors: Awarded Predoctoral
Fellowship from Epilepsy Foundation of America; Awarded Eli Lilly
Outstanding Graduate Student in Neuroscience Travel Fellowship - 2005)
Currently, Director of Medical News and Perspectives, Journal of the
American Medical Association.
2000 - 2004 Lisa Sharkey, Neuroscience Training Program (Awarded Ph.D. Papers:
primary author of 1 paper, coauthor of 1 paper, 3 abstracts; Honors:
Awarded Eli Lilly Outstanding Graduate Student in Neuroscience Travel
Fellowship – 2002). Currently - Research Investigator in Dr. Henry
Paulson laboratory, Univ. of Michigan
1998 - 2003 Jessica Holden-Kloda, Molecular and Cellular Pharmacology Training
Program (Awarded Ph.D. Honors: Awarded predoctoral fellowships from
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Epilepsy Foundation of America and from Pharmaceutical Manufacturers
of America Papers: primary author of 2 papers, 5 abstracts.) Currently:
Regulatory Compliance Specialist, Technical Resources International Inc.
Bethesda, MD
1997- 2001 Jeremy Teissere, Neuroscience Training Program (Awarded Ph.D.
Honors: Awarded individual predoctoral NRSA from NIH Papers:
primary author two papers, coauthor of one paper, 4 abstracts) Currently:
Associate Professor at Muhlenberg College, Stanley Road Endowed Chair,
Director Neuroscience Program, Allentown, PA.
1997-1998 Jolien Connor, Neuroscience Training Program (left program, Papers:
primary author of 1 paper and 1 abstract; Currently: Scientist – facility
manager of confocal microscope facility, University of Wisconsin –
Madison.
Predoctoral Sponsored Laboratory Rotations:
2014 Caitlin Short Neuroscience Training Program
John Cowgill Biophysics Training Program
Harrison Pantera Molecular and Cellular Pharmacology Program
Jenn Borchardt Cell and Molecular Biology
2013 Joseph Wszalek Neuroscience Training Program (JD/PhD)
2012 Khoa Tran Molecular and Cellular Pharmacology Program
Emily Grant Molecular and Cellular Pharmacology Program
Joe Pasquarelle Molecular and Cellular Pharmacology Program
Erin Hannigan Neuroscience Training Program
Tzu-Wei Tsao Physiology Training Program
Sonalee Bathakur Physiology Training Program
Varun Tiwari Biophysical Training Program
2011 Ewa Bomba Neuroscience Training Program
2010 Kevin Oesltrom Molecular and Cellular Pharmacology Program
Mike Devinney Neuroscience Training Program
2008 Nima Ghitani Neuroscience Training Program
Borna Ghosh Biophysical Training Program
Valerie Grant Neuroscience Training Program
2007 Lindsay Pascal Neuroscience Training Program
Elaine Morlock Molecular and Cellular Pharmacology Program
Deborah Capes Molecular and Cellular Pharmacology Program
Andrew Petersen Molecular and Cellular Pharmacology Program
Joe Esquibel Molecular and Cellular Pharmacology Program
2005 Neil Daily Molecular and Cellular Pharmacology Program
Kelly Christopherson Molecular and Cellular Pharmacology Program
2003 Dominique Fontanilla Molecular and Cellular Pharmacology Program
Cynthia Koziol Molecular and Cellular Pharmacology Program
Cassie Theusch Cell and Molecular Biology Program
2002 Jose Mercado Neuroscience Training Program
2001 Feyza Sancar Neuroscience Training Program
Reema Jasuja Molecular and Cellular Pharmacology Program
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Ashley Doane Molecular and Cellular Pharmacology Program
2000 Lisa Sharkey Neuroscience Training Program
Xue Han Department of Physiology Training Program
Qi-Qi Cui Department of Physiology Training Program
Jill Sakai Neuroscience Training Program
1999 Anthony Guillen Department of Physiology Training Program
1998 Jessica Holden Molecular and Cellular Pharmacology Program
Allison Friedlein Molecular and Cellular Pharmacology Program
Gail Seabold Molecular and Cellular Pharmacology Program
Eric Peden Molecular and Cellular Pharmacology Program
Michel Parsons Neuroscience Training Program
1997 Jolien Connor Neuroscience Training Program
Regan Thieller MD/PhD Training Program
Scott Doughman Molecular and Cellular Pharmacology Program
Jeremy Teissere Neuroscience Training Program
1996 Monika Davare Molecular and Cellular Pharmacology Program
John C. Zella Department of Neurophysiology Training Program
1995 Soren Leonard Molecular and Cellular Pharmacology Program
Predoctoral Thesis Committees:
1994 - 1996 HaiGuang Zhang , Physiology Training Program (M. Jackson -advisor)
1995 - 1996 Inyeong Choi, Developmental Biology Training Program ( B. Chiu -
advisor)
1995 - 1998 Jeannie David, Neuroscience Training Program (L. Trussel - advisor)
1995 - 1998 Matthew Trudeau, Physiology Training Program (G. Robertson - advisor)
1995 - 1999 Xiao-Shen Li , Zoology Training Program (R. Pearce - advisor)
1995 - 2000 Tongbin Li, Neuroscience Training Program (R. Pearce - advisor)
1995 - 2000 Brian Spencer, Medical Microbiology & Immunology Training Program
(C. Brandt - advisor)
1996 - 2001 Jinling Wang, Physiology Training Program (G. Robertson - advisor)
1997 - 2000 Monika Devare, Molecular and Cellular Pharmacology Program (J. Hell –
advisor)
1997 - 2001 David Thiriot, Molecular and Cellular Pharmacology Program (A. Ruoho
- advisor)
1998 - 2000 Sean O’Shea, (University of Chicago, Dr. Neil Harrison - major professor)
1999 - 2001 Bimal Vyas, Neuroscience Training Program (E. Chapman - advisor)
1999 - 2002 Chris Ahern, Physiology (R. Coronado – advisor)
1999 - 2003 Gail Seabold, Molecular and Cellular Pharmacology Program (J. Hell -
advisor)
2000 - 2003 Jihong Bai, Biophysics Training Program (E. Chapman - advisor)
2001 - 2003 David Sheridan, Physiology (R. Coronado – advisor)
2002 - 2004 Christine Angevine, Biomolecular Chemistry (R. Fillingame – advisor)
2000 - 2004 Min Dong, Neuroscience Training Program (E. Chapman - advisor)
2000 - 2004 Eric Kinzler, Cell and Molecular Biology (Teresa Compton – advisor)
2003 - 2005 Xue Han, Physiology Training Program (M. Jackson – advisor)
2000 - 2005 Jason Hardie, Neuroscience Training Program (R. Pearce – advisor)
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2001 - 2006 Yukiko Muroi, Molecular and Cellular Pharmacology Program (M.
Jackson – advisor)
2002 - 2006 Weijun Chang, Physiology Training Program (R. Coronado – advisor)
2002 - 2006 Adam Feire, Cell and Molecular Biology (Teresa Compton – advisor)
2003 – 2005 Adam Rucker, Neuroscience Training Program (G. Robertson – advisor)
2002 - 2006 Rebekah Jakel, Neuroscience Training Program (J. Johnson – advisor)
2003 - 2006 Reema Jasuja, Molecular and Cellular Pharmacology Program (D.
Greenspan – advisor)
2003 - 2007 Pallavi Phartiyal, Cell and Molecular Biology (G. Robertson – advisor)
2006 – 2008 Shu Mao, Physiology Training Program (G. Marriot – advisor)
2003 – 2008 Subramaniam Ramachandran, Molecular and Cellular Pharmacology
Program (A. Ruoho – advisor)
2005 – 2009 Sarah Wynia, Cell and Molecular Biology (G. Robertson – advisor)
2005 - 2009 Enfu Hui, Biophysics Training Program (E. Chapman - advisor)
2004 – 2009 Elon Roti Roti, Cell and Molecular Biology (G. Robertson – advisor)
2004 – 2010 Dominique Fontanilla, Molecular and Cellular Pharmacology Program (A.
Ruoho – advisor)
2005 – 2010 Chuenchanok Frasier, Neuroscience Training Program (T. Martin –
advisor)
2006 – 2010 Cabell Jonas, Cell and Molecular Biology (L. Puglielli– advisor)
2006 – 2010 Michelle Perry, Molecular and Cellular Pharmacology Program (A. Kelley
– advisor)
2007 – 2010 Molly Johannessen, Physiology Training Program (M. Jackson – advisor)
2009 – 2010 Sarah Baisley, Neuroscience Training Program (C. Auger – advisor)
2005 - 2011 Felix Yeh, Molecular and Cellular Pharmacology Program (E. Chapman -
advisor)
2005 – 2011 Brian Torres, Molecular and Cellular Pharmacology Program (A. Ruoho –
advisor)
2007 – 2012 Jesus Mena, Neuroscience Training Program (B. Baldo – advisor)
2007 – 2012 Corinne Vokoun, Molecular and Cellular Pharmacology Program (M.
Basso – advisor)
2008 – 2012 Deborah Capes, Molecular and Cellular Pharmacology Program (B.
Chanda – advisor)
2008 – 2012 Sung (Sam) E Kwon, Physiology Training Program (E. Chapman -
advisor)
2008 – 2013 Shilpashree Balakrishnan, Neuroscience Training Program (R. Pearce –
advisor)
2006 – 2013 Neil Daly, Molecular and Cellular Pharmacology Program (T. Martin –
advisor)
2008 – 2015 Joseph Esquibel, Molecular and Cellular Pharmacology Program (T.
Martin – advisor)
2010 – 2015 Lindsey Roper, Molecular and Cellular Pharmacology Program (E.
Chapman - advisor)
2011 – 2015 Che-wei Chang, Physiology Training Program (M. Jackson, advisor)
2013 – 2015 Joe Pasquarella, Molecular and Cellular Pharmacology Program (R.
Kalejta – advisor)
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2011 – 2015 Kevin Oelstrom, Molecular and Cellular Pharmacology Program (B.
Chanda – advisor)
2011 – 2015 Yun Ding, Neuroscience Training Program (L. Puglielli– advisor)
2011 – 2016 Brandon Wright, Physiology Training Program (M. Jackson, advisor)
2012 – pres Yaxian Zhao, Physiology Training Program (G. Robertson, advisor)
2013 - pres Sofiya Hupalo, Neuroscience Training Program (C. Berridge– advisor)
2013 - pres Ben Haehnel, Biophysics Training Program (B. Chanda - advisor)
Undergraduate Research Training:
2015 - pres Teja Karimikonda, Neuroscience 699, Independent Research Training
(Honors: “University of Wisconsin Sophomore Research Fellowship”)
2013- 2014 Stephen Emmerling, Neuroscience 699, Independent Research Training
2011 - 2013 Abby Schuh, Physiology 699, Independent Research Training (Papers:
coauthor one paper) Currently: Medical Student - Univ. Wisconsin
2009 – 2012 Lamin Manneh, Independent Research Training
2008 - 2009 Erik Vaklyes, Independent Research Training
2007 Heather Meiselman, Biology 335 – Entering research, independent
research training
2005 – 2007 Say Thao, Minority Summer Research Program, Independent Research
Training (Papers: coauthor of 2 abstracts)
2005 – 2006 Pedro Warff, Minority Summer Research Program, Independent Research
Training (Papers: coauthor of 1 abstract)
2003 - 2004 Whitney Pafford, Independent Research Training, Senior Honors Thesis
2002 - 2004 Jeremy Bushman, Independent Research Training (Honors: “2003 Pfizer
Fellowship for Undergraduate Research”)
2001- 2002 Ross McDermitt, Molecular Biology Program, Senior Honors Thesis
(Honors: “2001 Trewartha Undergraduate Research Grant” and
“Outstanding Undergraduate NeuroscienceThesis Award” Papers:
coauthor of 1 paper, 1 abstract)
2000 - 2002 James Clark, Dept of Chemical Engineering, Independent Study (Papers:
coauthor of 1 paper)
1997 - 2000 Lisa Ann Wheeler, Dept. of Bacteriology, Independent Study
1998 - 1999 Jeff Malik, Dept. of Zoology and Psychology, Independent Study
1997 - 1998 Amy Evers, Senior Honors Thesis, Molecular Biology Program (Honors:
“University Bookstore Academic Excellence Award” and “Outstanding
Undergraduate NeuroscienceThesis Award”; Papers: coauthor of 2
papers)
1997 - 1998 Peter Ward, Senior Honors Thesis, Molecular Biology Program, (Honors:
“1997 Trewartha Undergraduate Research Grant”; Papers: coauthor of 1
paper, 1 abstract)
1996 - 1997 Robert Chang, Honors Senior Thesis, Molecular Biology Program,
(Honors: “1996 Trewartha Undergraduate Research Grant”)
1996 - 1997 Amy Evers, Independent Study-GABAA Receptors,
1995 - 1996 Anson Davis, Senior Honors Thesis, Molecular Biology Program, Papers:
coauthor of 1 paper)
Summer ‘96 Joy Price, Visiting Minority Undergraduate Research Fellow
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1994 - 1995 Anson Davis, Independent Study - Ligand-Gated Ion Channels
Summer ‘95 Polo Chen, Medical Scholars Undergraduate Research Trainee, U. of
Wisconsin-Madison (Papers: 1 abstract)
Outreach Training:
2014 Teja Karimikonda, Summer Research Internship for High School students,
Madison Metropolitan School District
2015 - 2016 Bailey Connery, Wisconsin Youth Apprenticeship Program, educating
high school senior student in biotechnology.
PUBLICATIONS (primary journal articles)
1. Borden, L. A., CZAJKOWSKI, C., Chan, C. Y. and Farb, D. H. (1984)
Benzodiazepine receptor synthesis and degradation by neurons in culture. Science
226: 857-859.
2. Gibbs, T. T., Chan, C. Y., CZAJKOWSKI, C., and Farb, D. H. (1985)
Benzodiazepine receptor photoaffinity labeling: Correlation of function with
binding. Eur. J. Pharmacol. 110: 171-180.
3. CZAJKOWSKI, C. M. and Farb, D. H. (1986) Transmembrane topology and
subcellular distribution of the benzodiazepine receptor. J. Neurosci. 6:2857-2863.
4. CZAJKOWSKI, C., Gibbs, T. T., and Farb, D. H. (1989) Transmembrane
topology of the gamma-aminobutyric acidA/benzodiazepine receptor: Subcellular
distribution and allosteric coupling determined in situ. Mol. Pharmacol. 35:75-84.
5. CZAJKOWSKI, C. and Farb, D. H. (1989) Identification of an intracellular pool
of gamma-aminobutyric acidA/benzodiazepine receptors en route to the cell
surface of brain neurons in culture. Mol Pharmacol 35:183-188.
6. CZAJKOWSKI, C., DiPaola, M., Bodkin, M., Salazar-Jimenez, G., Holtzman, E.,
and Karlin A. (1989) The intactness and orientation of acetylcholine
receptor-rich membrane from Torpedo californica electric tissue. Arch. Biochem.
Biophys. 272:412-420.
7. DiPaola, M., CZAJKOWSKl, C., and Karlin, A. (1989) The sidedness of the
C-terminus of the acetylcholine receptor delta subunit. J. Biol. Chem. 264:
15457-15463.
8. CZAJKOWSKI, C. and Karlin, A. (1991) The agonist binding site of Torpedo
electric tissue nicotinic acetylcholine receptor: A negatively charged region of the
delta subunit within 0.9 nm of the alpha subunit binding site disulfide. J. Biol.
Chem. 266:22603-22612.
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9. CZAJKOWSKI, C., Kaufmann, C., and Karlin, A. (1993) Negatively charged
amino acid residues in the nicotinic receptor delta subunit that contribute to the
binding of acetylcholine. Proc. Natl. Acad. Sci. USA 90:6285-6289.
10. CZAJKOWSKI, C., and Karlin, A. (1995) Structure of the nicotinic receptor
acetycholine binding site: Identification of acidic residues in the delta subunit
within 0.9 nm of the alpha subunit binding site disulfide. J. Biol. Chem.
270:3160-3164.
11. Martin, M., CZAJKOWSKI, C., and Karlin, A. (1996) The contributions of
aspartyl residues in the acetylcholine receptor and subunits to the binding of
agonists and competitive antagonists. J. Biol. Chem. 271:13497-13503.
12. Krasowski, M.D., O’Shea, S. M., Rick, C. E., Whiting, P.J., Hadingham, K. L.,
CZAJKOWSKI, C., and Harrison, N. L. (1997) Alpha subunit isoform influences
GABAA receptor modulation by propofol. J. Neuropharmacol. 36(7): 941-949.
13. Boileau, A.J., Evers, A.R., Kucken, A.M. & CZAJKOWSKI, C. (1998)
Molecular dissection of benzodiazepine binding and allosteric coupling
using chimeric GABAA receptor subunits. Mol. Pharmacol. 53: 295-303.
14. Connor, J. X., Boileau, A. J., CZAJKOWSKI, C. (1998) GABAA receptor
1-EGFP fusion protein requires a subunit for functional surface
expression. J. Biol. Chem. 273:28906-28911.
15. Boileau, A.J., Evers, A. R., Davis, A. F. and CZAJKOWSKI, C. (1999)
Mapping the agonist binding site of the GABAA receptor: Evidence for a
beta-strand. J. Neurosci. 19: 4847-4854.
16. Boileau, A.J. and CZAJKOWSKI, C. (1999) Identification of transduction
elements for benzodiazepine modulation of the GABAA receptor: three
residues are required for allosteric coupling. J. Neurosci. 19: 10213-
10220.
17. Li, X., CZAJKOWSKI, C. and Pearce, R. A. (2000) Rapid and direct
modulation of GABAA receptors by halothane. Anesthesiology 92:1366-
1375.
18. Kucken, A. M., Wagner, D, Ward, P.,Teissére, J.A., Boileau, A.J. and
CZAJKOWSKI, C. (2000) Identification of Benzodiazepine Binding Site
Residues on the 2 Subunit of the GABAA Receptor. Mol. Pharmacol.
57:932-939.
19. Wagner, D. A. and CZAJKOWSKI, C. (2001) Structure and dynamics of
the GABA binding pocket: a narrowing cleft that constricts during
activation. J. Neurosci. 21:67-74
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20. Horenstein, J., Wagner, D.A., CZAJKOWSKI, C. and Akabas, M.H.
(2001) Protein mobility and GABA-induced conformational changes
detected in the GABA-A receptor channel-lining M2 segment. Nature
Neuroscience 4:477-485.
21. Teissére, J.A and CZAJKOWSKI, C. (2001) A -strand forms part of the
benzodiazepine binding site of the GABA-A receptor: Structural
rearrangements detected during channel activation. J. Neurosci. 21: 4977-
4986.
22. *Boileau, A.J., *Newel, J. G., CZAJKOWSKI, C. (2002) GABAA Receptor 2
Y97 and L99 Line the GABA Binding Site: Insights into Mechanisms of Agonist
and Antagonist Actions (* co-first authors). J. Biol. Chem. 277:2931-2937.
23. Holden, J. H. and CZAJKOWSKI, C. (2002) Different residues in the GABA-A
receptor 1T60-1K70 region mediate GABA and SR-95531 actions. J. Biol.
Chem. 277: 18785-18792.
24. Boileau, A.J., Baur, R., Sharkey, L. M., Sigel, E. & CZAJKOWSKI, C. (2002)
The relative amount of cRNA coding for [gamma]2 subunits affects stimulation
by benzodiazepines in GABAA receptors expressed in Xenopus oocytes.
Neuropharmacology 43: 695- 700.
25. *Bowser, D.N., *Wagner, D.A., CZAJKOWSKI, C., Cromer, B.A., Parker,
M.W., Wallace, R.H., Harkin,L.A., Mulley, J.C., Marini, C., Berkovic, S.F.,
Williams, D.A., Jones, M.V. and Petrou, S. (2002) Altered kinetics and
benzodiazepine sensitivity of a GABA-A receptor subunit mutation(-R43Q)
found in human epilepsy (* co-first authors). Proc. Natl. Acad. Sci. 99: 15170-
15175.
26. *Kucken, A.M., *Teissére, J.A., Seffinga-Clark, J., Wagner, D.A. and
CZAJKOWSKI, C. (2003) Structural requirements for imidazobenzodiazepine
binding to GABA-A receptors (* co-first authors). Mol. Pharmacol. 63: 289 -296.
27. Newell, J. G. and CZAJKOWSKI, C. (2003) The GABA-A receptor 1 subunit
Pro174-Asp191 segment is involved in GABA binding and channel gating. J.
Biol. Chem. 278:13166-13172.
28. Boileau, A.J., Li, T., Benkwitz, C, CZAJKOWSKI, C and Pearce, R.A. (2003)
Effects of 2S Subunit Incorporation on GABAA Receptor Macroscopic Kinetics.
Neuropharmacology 44: 1003-1012.1.
29. Wagner, D.A., CZAJKOWSKI, C., and Jones, M.V. (2004) An arginine involved
in GABA binding and unbinding but not gating of the GABA-A receptor. J.
Neurosci. 24: 2733-2741.
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30. Sancar, F. and CZAJKOWSKI, C. (2004) A GABA-A receptor mutation linked to
human epilepsy (2 R43Q) impairs cell surface expression of receptors. J.
Biol. Chem. 279: 47034-47039
31. Newell, J. G., McDevitt, R. A. and CZAJKOWSKI, C. (2004) Mutation of
Glutamate 155 of the GABAA Receptor 2 Subunit Produces a Spontaneously
Open Channel: A Trigger for Channel Activation. J. Neurosci. 24: 11226-11235.
(Paper was highlighted in “This Week in the Journal” in the December 15th issue
as a new and important paper in the field).
32. CZAJKOWSKI, C. (2005) Triggers for channel opening. Nature 438: 167-168.
33. Boileau, A.J., Pearce, R. A. and CZAJKOWSKI, C. (2005) Tandem subunits
effectively constrain GABA-A receptor stoichiometry and recapitulate receptor
kinetics but are insensitive to GABA-A receptor-associated protein. J. Neurosci.
25:11219-11230.
34. Mercado, J. and CZAJKOWSKI, C. (2006) Charged residues in the 1 and 2
pre-M1 regions involved in GABA-A receptor activation. J. Neurosci. 26:2031-
2040.
35. Muroi, Y., CZAJKOWSKI, C. and Jackson, M.B. (2006) Local and global ligand-
induced changes in the structure of the GABA-A receptor. Biochemistry 45: 7013-
7022.
36. Sancar, F., Ericksen, S.S., Kucken, A.M., Teissere, J.A. and CZAJKOWSKI, C.
(2007) Structural determinants for high affinity zolpidem binding to GABA-A
receptors. Mol. Pharmacol 71: 38-46. Epub 2006 Sep 29.
37. Kloda, J. H. and CZAJKOWSKI, C. (2007) Agonist-, antagonist-, and
benzodiazepine-induced structural changes in the 1Met113-Leu132 region of the
GABA-A receptor. Mol. Pharmacol 71: 483-493. Epub 2006 Nov 15.
38. Hanson, S. M. and CZAJKOWSKI, C. (2008) Structural mechanisms underlying
benzodiazepine modulation of the GABAA receptor. J. Neurosci. 28: 3490-3499.
PMCID: PMC2410040
39. Mercado, J. and CZAJKOWSKI, C. (2008) GABA and pentobarbital induce
different conformational rearrangements in the GABAA receptor 1 and 2 pre-
M1 regions. J. Biol. Chem. 283: 15250-15257. PMCID: PMC2397470 [Available
on 2009/05/30]
40. Sharkey, L. M. and CZAJKOWSKI, C. (2008) Individually monitoring ligand-
induced changes in the structure of the GABA-A receptor at benzodiazepine
Czajkowski CV
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binding site and non-binding site interfaces. Mol. Pharmacol. 74: 1-10. PMCID:
PMC2552402 [Available on 2009/07/01]
41. Venkatachalan, S. and CZAJKOWSKI, C. (2008) A conserved salt-bridge critical
for GABAA receptor function and loop C dynamics. Proc. Natl. Acad. Sci. 105:
13604-13609. PMCID: PMC2533236
42. Hanson, S.M., Morlock, E.V., Satyshur, K.A., and CZAJKOWSKI, C. (2008)
Structural requirements for eszopiclone and zolpidem binding to the GABAA
receptor are different. J. Med. Chem. 51: 7243-7252. PMCID: PMC2645942
[Available on 2009/11/27]
43. Muroi, Y., Theusch, C.M., CZAJKOWSKI, C., and Jackson, M.B. (2009) Distinct
structural changes in the GABA-A receptor elicited by pentobarbital and GABA.
Biophysical Journal. 96: 499-509. PMCID: PMC2716461 (Paper was one of five
highlighted papers for the January 21st issue. Paper received a Faculty of 1000
Medicine citation
http://www.f1000medicine.com/article/sdbcckcvdv120fk/id/1157215).
44. Boileau, A.J., Pearce, R. A. and CZAJKOWSKI, C. (2010) The short splice
variant of the 2 subunit acts as an external modulator of GABAA receptor
function. J. Neurosci. 30: 4895-4903 PMCID: PMC2891256
45. Wagoner, K.R. and CZAJKOWSKI, C. (2010) Stoichiometry of Expressed
42 -aminobuytric acid type A receptors depends on the ratio of subunit
cDNA transfected. J. Biol. Chem. 285: 14187-14194 PMCID: PMC2863200
[Available on 2011/5/7]
46. Hanson, S.M. and CZAJKOWSKI, C. (2011) Disulfide trapping of the GABA-A
receptor reveals the importance of the coupling interface in benzodiazepine
action. British J. Pharmacol. 162:673-687. PMCID: PMC3041256
47. Sancar, F. and CZAJKOWSKI, C. (2011) Allosteric modulators induce distinct
movements at the GABA-binding site interface of the GABA-A receptor.
Neuropharmacology 60:520-528. PMCID: PMC3026633 [Available on 2012/2/1]
48. Dellisanti, C.D., Hanson, S.M., Chen, L. and CZAJKOWSKI, C. (2011) Packing
of the extracellular domain hydrophobic core has evolved to facilitate pentameric
ligand-gated ion channel function. J. Biol. Chem. 286: 3658-3670. PMCID:
PMC3030369 [Available on 2012/2/4]
49. Morlock, E. V. and CZAJKOWSKI, C. (2011) Different residues in the GABA-A
receptor benzodiazepine binding pocket mediate benzodiazepine efficacy and
binding. Mol. Pharmacol. 80: 14-22 PMCID: PMC3127544 [Available on
2012/7/1]
Czajkowski CV
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50. Venkatachalan SP and CZAJKOWSKI, C. (2012) A structural link between the
GABA-A receptor’s agonist binding site and inner -sheet governs channel
activation and allosteric drug modulation. J. Biol. Chem. 287: 6714-6724
PMCID: PMC3307325
51. Ghosh, B. and CZAJKOWSKI, C. (2013) Propofol binding to the resting state of
the Gloeobacter violaceus ligand gated ion channel (GLIC) induces structural
changes in the inter and intra-subunit trans-membrane domain (TMD) cavities. J.
Biol. Chem. 288: 17420-17431.
52. Dellisanti, C.D., Ghosh, B. Hanson, SM, Raspanti, JM, Grant, VA, Diarra, GM,
Schuh, AM, Satyshur, K, Klug, CS and CZAJKOWSKI, C. (2013) Site-directed
spin labeling reveals pentameric ligand-gated ion channel gating motions. PLoS
Biol 11(11): e1001714. doi:10.1371/journal.pbio.1001714 (Paper highlighted in
editor’s weekly pick)
53. Laha, K.T., Ghosh, B and CZAJKOWSKI, C. (2013) Macroscopic Kinetics of
Pentameric Ligand Gated Ion Channels: Comparisons between Two Prokaryotic
Channels and One Eukaryotic Channel. PLoS ONE 8(11): e80322.
doi:10.1371/journal.pone.0080322
54. Ding, Y., Dellisanti, C., Ko, M., CZAJKOWSKI, C. and Puglielli, L. (2014) The
Er-Based Acetyltransferases, Atase1 And Atase2, Associate With The Ost
Complex To Acetylate Correctly Folded Polypeptides. Journal of Biological
Chemistry 289: 32044-32055 PMCID: PMC4231681
PUBLICATIONS (review articles and book chapters)
1. Farb, D. H., Borden, L. A., Chan, C. Y., CZAJKOWSKI, C., Gibbs, T. T., and
Schiller, G. D. (1984) Modulation of neuronal function through benzodiazepine
receptors: Biochemical and electrophysiological studies of neurons in primary cell
culture. Annals of the New York Academy of Sciences 435: 1-31.
2. Farb, D. H., CZAJKOWSKI, C. M., Borden, L. A., Schiller, G. D., and Gibbs, T.
T. (1986) Turnover of the benzodiazepine/GABA receptor complex determined
in situ. In: “Advances in Biochemical Psychopharmacology”. Eds.: Biggio, G. and
Costa, E. Raven Press, 51-66.
3. Andrew J. Boileau, Amy Kucken, Amy R. Evers and Cynthia CZAJKOWSKI
(1999) Molecular dissection of the GABAA receptor: The N-terminal domain of
the 2 subunit is essential for benzodiazepine binding and subunit assembly.
Peptides: Frontiers of Peptide Science, pp 508-511, Kluwer Academic Publishers,
The Netherlands.
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4. Newell, J. G. and CZAJKOWSKI, C (2005) Scanning Cysteine Mutagenesis:
Mapping Binding Sites of Ligand-gated Ion Channels (Chapter 21) in Handbook
of Neurochemistry and Molecular Biology, Vol 18. Abel Lajtha, Editor in Chief,
Published by Springer. New York, NY.
PUBLICATIONS (abstracts)
1. Borden, L. A., C. CZAJKOWSKI, and Farb, D. H. (1981) Distribution of GABA
transport sites in embryonic chick spinal cord neurons in cell culture. Soc.
Neurosci. Abstr. 7: 367.
2. CZAJKOWSKI, C. and Farb, D. H. (1983) Analysis of benzodiazepine receptor
turnover in cell culture by SDS gel electrophoresis. Soc. Neurosci. Abstr. 9: 365.
3. CZAJKOWSKI, C. and Farb, D. H. (1985) Evidence for cell surface and
sequestered benzodiazepine receptors in chick brain cell cultures. Soc. Neurosci.
Abstr. 11: 278.
4 CZAJKOWSKI, C. M., Mierlak, D., and Farb, D. H. (1986) Transmembrane
topology and distribution of the benzodiazepine receptor: Ro7-0213 as a probe for
cell surface receptors. Soc. Neurosci. Abstr. 12:664.
5. CZAJKOWSKI, C. M. and Farb, D. H. (1986) Subcellular distribution and
turnover of the benzodiazepine receptor in chick brain cell culture. J. Cell Biol.
Abstr. 103:375a.
6. Karlin, A., DiPaola, M., Kao, P., Wang, L., CZAJKOWSKI, C., Chak, A. (1988)
Functional sites of the nicotinic acetylcholine receptor. Puerto Rico Health
Science Journal, 7:75.
7. DiPaola, M., CZAJKOWSKI, C., Bodkin, M., and Karlin, A. (1988) The
C-terminus of the Torpedo acetylcholine receptor delta subunit is extracellular.
Soc. Neurosci. Abstr. 14:640.
8. CZAJKOWSKI, C. and Karlin, A. (1991) Mapping the negative subsite of the
nicotinic acetylcholine receptor agonist binding site. Soc. Neurosci. Abstr. 17:23.
9. CZAJKOWSKI, C., Kaufmann, C., and Karlin, A. (1992) Nicotinic receptor
delta subunit D180 and E189 contribute to the binding of acetylcholine. Soc.
Neurosci. Abst. 18: 597.
10. Karlin, A., Akabas, M.H., CZAJKOWSKI, C., Kaufmann, C., Stauffer, D. and
Xu, M. (1994) Structures involved in binding, gating, and conduction in
nicotinic acetylcholine receptors. Renal Physiol. Biochem. 17: 184-186.
11. Martin, M., CZAJKOWSKI, C. and Karlin, A. (1995) Acetylcholine receptor
gamma subunit ASP174 contributes to the binding of acetylcholine and curare.
Soc. Neurosci. Abst. 21:1583.
12. Boileau, A.J., Cozzi, N.V., Chen, P., and CZAJKOWSKI C. (1996)
Identification of GABA and Diazepam-responsive regions of the GABAA
receptor using 2/1 subunit chimeras. Soc. Neurosci. Abst. Vol. 22, Part 2, p.
1284.
13. O’Shea, S.M., Krasowski, M.D., Rick, C.E., Whiting, P.J., Hadingham, K.L.,
CZAJKOWSKI, C., and Harrison,N.L. (1996) Subunit-dependent modulation of
recombinant GABAA receptors by general anesthetics. Soc. Neurosci. Abst. Vol.
22, Part 2, p. 1289.
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14. Li, X, Banks, M., CZAJKOWSKI, C., and Pearce, R. A. (1997) Effect of
halothane on GABAA receptors studied using rapid application techniques.
American Society of Anesthesiologists Annual Meeting October 1997, San
Diego, CA.
15. Li, X.S., CZAJKOWSKI, C., and Pearce R.A. (1997) Patch excision alters
responses of expressed GABAA receptors to halothane. Soc. Neuroscience
Abstracts 23:104.
16. Boileau, A.J., Kucken, A.M. & CZAJKOWSKI, C. (1997) Uncoupling of GABA
and benzodiazepine responsive regions of the GABAA receptor using 2
subunit chimeras. Soc. Neurosci. Abstr., Vol. 23, Part 1, p. 951
17. Connor, J. X., Boileau, A.J. & CZAJKOWSKI, C. (1997) GABAA 1/EGFP
fusion protein requires a subunit for functional surface expression. Soc.
Neurosci. Abstr., Vol. 23, p. 112
18. Boileau, A.J. & CZAJKOWSKI, C. (1999) Uncoupling of BZD binding from
potentiation: Identification of GABAA receptor domains required for BZD
allosteric modulation. Soc. Neurosci. Abstr., Vol. 25, Part 1, p. 964.
19. Kucken, A.M., Teissére, J.A., Wagner D.A., Boileau A.J. & CZAJKOWSKI, C.
(1999) Identification of benzodiazepine binding site residues in the 2 subunit of
the GABAA receptor. Soc. Neurosci. Abstr., Vol. 25, Part 1, p. 964.
20. Teissére, J.A., Boileau, A.J. & CZAJKOWSKI, C. (1999) Elucidating the
structure of the benzodiazepine binding site on the GABAA receptor by
engineered sulfhydryl modification. Soc. Neurosci. Abstr., Vol. 25, Part 1, p. 964.
21. Holden, J.H., Boileau, A.J., Teissére, J.A., Wagner, D.A. & CZAJKOWSKI, C.
(1999) Mapping the agonist binding site of the GABAA receptor: Evidence for a
beta-strand. Soc. Neurosci. Abstr., Vol. 25, Part 1, p. 459.
22. Horenstein, J., Wagner, D.A., CZAJKOWSKI, C. & Akabas, M.H. (1999)
Relative mobility of the GABAA receptor M2 membrane-spanning segments
inferred by disulfide trapping. Soc. Neurosci. Abstr., Vol. 25, Part 2, p. 1712
23. Wagner, D.A., and CZAJKOWSKI, C. (2000) Cysteine mutagenesis of the V199
– S209 region of the GABA-A 2 subunit reveals a mobile domain of the GABA
binding pocket. Soc. Neurosci. Abstr.
24. Holden, J.H., Boileau, A.J. and CZAJKOWSKI, C. (2000) Characterization of
1F64, 1R66, and 1S68 of the GABA-A receptor:Their roles at the GABA
binding site. Soc. Neurosci. Abstr.
25. Teissere, J.A., Kucken, A.M., Wagner, D.A., Wheeler, L. and CZAJKOWSKI C.
(2000) A new model for orientation of class III ligands in the benzodiazepine
binding pocket of the GABA-A receptor. Soc. Neurosci. Abstr.
26. Banks, M.I., Saad, A.A., Czajkowski, C.M., and Pearce, R.A. (2001) Subunit-
specific modulation of recombinant GABA-A receptors by isoflurane. American
Society of Anesthesiologists Annual Meeting.
27. Holden, JH and CZAJKOWSKI C. (2001) Mapping agonist and antagonist
binding site subdomains in the 1M113-T125 region of the GABA-A receptor.
Soc. Neurosci. Abstr.
28. Newell, JG and CZAJKOWSKI, C (2001) Mutational analysis reveals the
importance of a novel domain of the GABA-A receptor 1 subunit for
agonist/antagonist binding. Soc. Neurosci. Abstr.
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29. Wagner, D.A. CZAJKOWSKI, C. and Jones, M.V. (2002) A putative binding
pocket residue in the GABA-A receptor selectively mediates unbinding kinetics
but not channel gating. Biophys J. 82:257a, poster# 1244.
30. Wagner, D.A., Bowser, D.N., CZAJKOWSKI, C., Cromer, B.A., Berkovic, S.F.,
Williams, D.A., Petrou, S. and Jones, M.V. (2002) The GABA-A receptor
mutation2(R43Q), found in humans with epilepsy, slows current decay and
increases desensitization. American Epilepsy Society Abstr. 2.042
31. Wagner, D.A., CZAJKOWSKI, C.M., Jones, M.V. (2002) Arginine 207 of the
beta2 subunit of the GABA-A receptor selectively mediates unbinding kinetics
but not channel gating. Soc. Neurosci. Abstr. 40.6.
32. Newell, J.G., McDevitt, R.A. and CZAJKOWSKI, C (2002) Mutation of a
GABA-A receptor bindng site residue produces a constitutively open channel.
Soc. Neurosci. Abstr. 40.3.
33. Sharkey, L.M. and CZAJKOWSKI, C (2002) Evidence that the two subunit
interfaces ( and ) of the GABA-A receptor are structurally different and
play different roles in receptor function. Soc. Neurosci. Abstr. 40.4.
34. Holden, J.H. and CZAJKOWSKI, C. (2002) Identification of residues involved in
allosteric crosstalk between the GABA and benzodiazepine binding sites. Soc.
Neurosci. Abstr. 40.2.
35. Kucken, A.M. and CZAJKOWSKI, C. (2002) GABA-A receptor binding site
structure examined by intermolecular thiol cross-linking. Soc. Neurosci. Abstr.
40.1.
36. Boileau, A.J., Pearce, R.A. and CZAJKOWSKI, C (2002) Heterologous
expression of GABAA receptor subunits: What are we really making? Presented
at: GABA-A Receptors in Cellular and Network Excitability, Satellite symposium
of the 2002 Annual Meeting of the Society for Neuroscience, Orlando, Oct 31 -
Nov 2.
37. Sancar, F. and CZAJKOWSKI, C (2003) A GABA-A receptor mutation linked to
human epilepsy (2 R43Q) impairs receptor expression. Soc. Neurosci. Abstr.
38. Mercado, J. L. and CZAJKOWSKI, C (2003) Charged residues in the pre-M1
region of the GABA-A receptor play a role in coupling binding to gating. Soc.
Neurosci. Abstr.
39. Holden, J.H. and CZAJKOWSKI, C. (2003) 1Gly124-1Leu132: A novel binding
site region on the GABA-A receptor that undergoes distinct conformational
rearrangements during ligand binding and allosteric modulation. Soc. Neurosci.
Abstr.
40. Sharkey, L.M. and CZAJKOWSKI, C (2004) Asymmetric movements in the 1
and 2 subunits of the GABA-A receptor during channel gating. Biophysical Soc.
Abstr.
41. Kucken, A.M. and CZAJKOWSKI, C. (2004) GABA-A receptor binding site
dynamics examined by intermolecular thiol crosslinking. Soc. Neurosci. Abstr.
42. Sharkey, L.M. and CZAJKOWSKI, C (2004) 1V107-T112: A region that links
the GABA-A receptor’s BZD and GABA binding sites. Soc. Neurosci. Abstr.
43. Muroi, Y., Boileau, A.J., CZAJKOWSKI, C and Jackson, M.B. (2004)
Fluorescence probing of conformational transitions in the extacellular domain of
the GABA-A receptor. Soc. Neurosci. Abstr.
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44. Venkatachalan S., Sharkey L and CZAJKOWSKI C. (2005) Disruption of 2
K102-T110, a region that links the GABA-A receptor’s agonist binding site to the
inner -sheet domain, impairs channel activation. Gordon conference “Inhibition
in the Brain” July 2005.
45. Sancar F., Kucken A.M., Teissere J.A. and CZAJKOWSKI, C. (2005)
Determinants of high affinity zolpidem binding in the 2 subunit of the GABA-A
receptor. Soc. Neurosci. Abstr.
46. Theusch, CM and CZAJKOWSKI, C (2005) Mutation of M55 in the GABAA
receptor -induced activation. Soc. Neurosci.
Abstr.
47. Muroi Y, Boileau A J., CZAJKOWSKI C, and Jackson M. B. (2005) Agonists,
antagonists, and allosteric modulators produce different structural changes in the
GABAA receptor Soc. Neurosci. Abstr.
48. Venkatachalan S., Thao, S, Warff, P. and CZAJKOWSKI, C. (2006)
Identification of a 2 intra-subunit salt bridge critical for GABA-A receptor
activation. Biophysical Society Meeting, Biophys J. 90: 2629
49. Mercado, J. L. and CZAJKOWSKI, C (2007) GABA and pentobarbital induce
different conformational rearrangements in the 1 and 2 pre-M1 regions of the
GABAA receptor. Biophysical Society Meeting
50. Kucken, A.M. and CZAJKOWSKI C (2007) Motion of the GABA-A receptor
loop C binding site region. Soc. Neurosci. Abstr.
51. Hanson, S.M. and CZAJKOWSKI, C (2007) Loop F of the GABA-A receptor
gamma2 subunit is a determinant for benzodiazepine efficacy. Soc. Neurosci.
Abstr.
52. Theusch, C.M., Muroi, Y., CZAJKOWSKI, C. and Jackson, M (2007)
Pentobarbital-induced structural changes in the GABA-A receptor. Soc. Neurosci.
Abstr.
53. Mercado, J. and CZAJKOWSKI, C. (2007) Dynamics of the GABA-A receptor
beta2 Loop 9. Soc. Neurosci. Abstr.
54. Venkatachalan, S. and CZAJKOWSKI, C. (2007) Disruption of 2 K102-T110, a
region that links the GABA-A receptor’s agonist binding site to the inner b-sheet
domain, impairs channel activation. Soc. Neurosci. Abstr.
55. Venkatachalan, S., Thao, S. and CZAJKOWSKI, C. (2008) An intrasubunit salt-
bridge linking Loop A and Loop 2 is critical for GABA-A receptor activation.
Biophysical Society Meeting
56. Hanson, S.M., Morlock, E.V., Satyshur, K.A., and CZAJKOWSKI, C. (2008)
Defining the pharmacophore for eszopiclone and zolpidem in 1-containing
GABAA receptors. Society for Neuroscience Annual Meeting, Washington, D.C.,
2008.
57. Raspanti, J. and CZAJKOWSKI, C. (2008) Benzodiazepine association and
dissociation binding kinetics to the GABA-A receptor. 18th Neuropharmacology
conference ‘Ligand-gated ion channels’, Washington, D.C., 2008.
58. Christopherson, K. R. and CZAJKOWSKI, C. Using the alpha-bungarotoxin
binding site tag to determine stoichiometry of alpha4-beta2-delta GABA-A
receptors. 18th Neuropharmacology conference ‘Ligand-gated ion channels’,
Washington, D.C., 2008.
Czajkowski CV
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59. Theusch, CM, Hernandez, LH, Boileau, AJ, Jackson, MB, and CZAJKOWSKI, C
(2008) Voltage clamp fluorometry reveals M2 -helix conformational changes in
-aminobutyric acid receptor-type A 1 and 2 subunits. Society for Neuroscience
Annual Meeting, Washington, D.C., 2008, abstract 530.9.
60. Venkatachalan, S., Zimprich, C, Los, G.V. and CZAJKOWSKI, C. Live cell
imaging of mutant and wild-type GABA-A receptor trafficking using a novel
reporter protein. Society for Neuroscience Annual Meeting, Washington, D.C.,
2008.
61. Theusch, CM, Jackson, MB, and CZAJKOWSKI, C (2009) Site-specific
fluorescence reveals GABA-induced structural movements near the extracellular
end of the pore-lining M2 -helices of the GABA-A receptor. Biophysical
Society Meeting
62. Ghosh, B. and CZAJKOWSKI, C (2009) Mapping structural changes in the
GABAA receptor transmembrane domain using site-specific fluorescent labeling.
Society for Neuroscience Annual Meeting, Chicago, IL, 2009
63. Hanson, SM and CZAJKOWSKI, C (2009) Disulfide trapping of the GABA-A
receptor reveals the importance of the coupling interface in benzodiazepine
modulation. Society for Neuroscience Annual Meeting, Chicago, IL, 2009
64. Raspanti, J and CZAJKOWSKI, C (2009) Allosteric interactions between the
benzodiazepine and GABA binding sites of the GABAA receptor. Society for
Neuroscience Annual Meeting, Chicago, IL, 2009
65. Christopherson, KR and CZAJKOWSKI, C (2009) Stoichiometry of
42GABAA receptors expressed in HEK293T cells. Society for Neuroscience
Annual Meeting, Chicago, IL, 2009
66. Morlock, EV and CZAJKOWSKI, C (2009) Defining residues involved in the
efficacy of benzodiazepine modulation of GABAA receptor current. Society for
Neuroscience Annual Meeting, Chicago, IL, 2009
67. Ghosh, B., Hanson, SM and CZAJKOWSKI, C (2010) Mutational analysis of the
prokaryotic pentameric ligand-gated ion channel GLIC. Biophysical Society
Meeting
68. Dellisanti, CD, Hanson, SM, Chen, L and CZAJKOWSKI, C (2010) Packing of
the extracellular domain hydrophobic core is evolutionarily optimized to facilitate
pentameric ligand-gated ion channel activation. Biophysical Society Meeting
69. Morlock, EV and CZAJKOWSKI, C (2010) Defining residues involved in the
efficacy of benzodiazepine modulation of GABAA receptor current. Society for
Neuroscience Annual Meeting, San Diego, CA, 2010
70. Ghosh, B. and CZAJKOWSKI, C (2011) Mapping anesthetic induced
movements in the prokaryotic ligand-gated ion channel GLIC. Society for
Neuroscience Annual Meeting, Washington, DC, 2011
71. Dellisanti, C and CZAJKOWSKI, C (2011) Site-directed spin labeling reveals
pentameric ligand-gated ion channel gating motions. Society for Neuroscience
Annual Meeting, Washington, DC, 2011
72. Laha, KT and CZAJKOWSKI, C (2012) Prokaryotic ligand gated ion channels
exhibit distinct kinetic properties compared to the related eukaryotic cys-loop
receptors. Society for Neuroscience Annual Meeting, New Orleans, LA, 2012
73. Ghosh, B. and CZAJKOWSKI, C (2013) Propofol induced structural changes in
Czajkowski CV
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the TMD of the prokarylotic pLGIC GLIC. Biophysical Society Meeting
74. Ghosh, B. and CZAJKOWSKI, C (2013) Allosteric modulators induce
asymmetric motions in the inter- and intra-subunit TMD cavities of GABAARs.
Society for Neuroscience Annual Meeting, 2013
75. Ghosh, B., Tiwari, V and CZAJKOWSKI, C (2014) Construction and
characterization of a functional GLIC-GABArho ligand-gated ion channel
chimera. Biophysical Society 58th Annual Meeting
76. Dellisanti, C and CZAJKOWSKI, C (2014) Loose packing of the extracellular
domain core of pentameric ligand-gated ion channels is important for fast
activation and desensitization. Biophysical Society 58th Annual Meeting
77. Ghosh, B. Tsao, T. and CZAJKOWSKI C (2014) Allosteric modulation of
GABA-A receptors by different drugs. Biophysical Society 58th Annual Meeting
78. Teusch, C and CZAJKOWSKI C (2015) Disulfide trapping the GABA-A
receptor extracellular beta-5/beta-5' loop. Biophysical Society 59th Annual
Meeting
79. Tsao, T, Ghosh, B and CZAJKOWSKI C (2015) Monitoring motions in GABA-A
receptor intersubunit transmembrane cavities. Biophysical Society 59th Annual
Meeting
80. Tiwari, V, Schuh A., Klug, C. and CZAJKOWSKI C (2016) Radial tilting of the
extracellular domain of GLIC revealed by EPR spectroscopy Biophysical Society
60th Annual Meeting
MANUSCRIPTS IN PREPARATION
1. Kucken, A.M. and CZAJKOWSKI, C. GABA-A receptor binding site dynamics
examined by intermolecular thiol crosslinking.
2. Tsao, T, Ghosh, B and CZAJKOWSKI C. Monitoring drug-induced motions in
GABA-A receptor intersubunit transmembrane cavities.
3. Theusch, CM, Jackson, MB, and CZAJKOWSKI, C. Site-specific fluorescence
reveals GABA-induced structural movements near the extracellular end of the
pore-lining M2 -helices of the GABA-A receptor.
4. Tiwari, V, Klug, C. and CZAJKOWSKI C. Radial tilting of the extracellular
domain of GLIC revealed by EPR spectroscopy.
5. Ghosh, B., Tiwari, V and CZAJKOWSKI, C. Construction and characterization of
a functional GLIC-GABArho ligand-gated ion channel chimera.
INVITED RESEARCH PRESENTATIONS
1993 Einstein University, School of Medicine, Dept. of Anatomy
Czajkowski CV
21
1993 University of Miami, Dept. of Physiology
1993 Cornell University, School of Medicine, Dept. of Pharmacology
1993 University of Chicago, Depts. of Anesthesiology and Pharmacology
1993 University of Vermont, School of Medicine, Dept. of Physiology
1993 University of Wisconsin, School of Medicine, Dept. of Neurophysiology
1994 Cornell University, School of Medicine, Dept. of Physiology
1996 Vanderbilt University, Department of Pharmacology, School of Medicine
1997 The American Peptide Symposium, Nashville, TN, invited symposium speaker
1998 Burroughs Wellcome Fund “1998 New Investigators Meeting” Invited Speaker
1998 University of Chicago, Dept. of Anesthesia & Critical Care and Dept. of
Physiology
1999 Winter Brain Conference, Invited Panel Speaker on GABAA receptors
1999 University of Alberta, Edmonton, Canada, Department of Pharmacology and
Division of Neuroscience
1999 University of Vermont, School of Medicine, Department of Biochemistry
2000 Boston University, Department of Pharmacology and Experimental Therapeutics
2000 University of Utah, Department of Neuroscience
2001 Winter Brain Conference, Invited Panel Speaker on GABAA receptors
2001 University of Puerto Rico in Cayey, RISE Program
2001 Ponce School of Medicine – Puerto Rico, Graduate program
2001 Pontificia Universidad Catolica de Puerto Rico, NIH Marc Honor Program
2001 University of Alabama, Neurobiology Seminar Program
2001 Marquette University, Dept. of Chemistry
2002 University of Colorado Health Sciences Center, Dept. of Pharmacology
2002 National Institutes of Health, NIAAA, Invited Symposium Speaker on Ion
Channel Structure/Function
2002 State University of New York, Health Science Center at Brooklyn, Department of
Physiology
2003 Louisiana State University, School of Medicine, Center for Neuroscience
2003 Neurion, Pasadena, CA (private company interested in targeted drug development
for ion channels)
2004 Biophysical Society Annual Meeting, Invited Symposium Speaker on Ion Channel
Gating
2004 Gordon Research Conference on Ligand Recognition and Molecular Gating,
Invited Symposium Speaker
2004 College de France, Paris, France, Distinguished Lectureship
2004 Merck Sharpe & Dohme, Harlow, Essex – England, Invited speaker on the
contribution of LGIC structure to channel function
2004 UCLA, Invited speaker in GABA-A receptor symposium
2004 College of London, School of Pharmacy
2004 University of Chicago, Neurobiology Seminar Series
2004 Gordon Research Conference on Ion Channels, Invited Panel Speaker
2004 University of Iowa, Department of Pharmacology and Neuroscience
2005 American Society of Neurochemisty, Invited Host Committee/Organizer, declined
2005 20th Biennial Meeting Int. Soc. Neurochem. & the European Soc. for
Neurochem.,Vienna – Austria Invited Symposium Speaker
Czajkowski CV
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2005 Gordon Research Conference on Inhibition in the CNS, Invited Panel Speaker
2005 Tufts Medical School, Department of Neuroscience
2006 Sepracor, Marlborough, MA
2007 Emory University, Neuroscience Program
2007 University of Chicago, Neurobiology Seminar Series
2007 Gordon Research Conference on Inhibition in the CNS, Invited Panel Speaker
2007 State University of New York at Buffalo, Dept. of Physiology and Biophysics
2008 Washington University School of Medicine, Dept. of Anesthesiology
2008 University of North Carolina at Chapel Hill, Neuroscience Center
2008 Neuropharmacology Satellite Meeting “Ligand-gated Ion Channels”, Invited
symposium speaker (satellite meeting at Society of Neuroscience Annual
Meeting)
2009 Biochemical Society Focused Meeting “Neuronal glutamate and GABA(A)
receptor function in health and disease”, St. Andrews, Scotland, UK, Invited
Speaker
2009 Journal of Physiology Symposium “Advances and hold-ups in the study of
structure, function and regulation of Cys-loop ligand-gated ion channels and
receptors”, Chicago, Invited Speaker (satellite meeting at Society of
Neuroscience Annual Meeting)
2010 Gordon Research Conference on Ion Channels, Invited Panel Speaker
2010 Promega Corporation, Madison, WI, Invited Speaker
2010 GABA 2010, San Servolo, Italy, Invited Symposium speaker, declined
2010 Mechanisms of Anesthesia Conference, Toronto, Canada, Invited Symposium
speaker
2011 University of Copenhagen, Denmark, Department of Medicinal Chemistry
PHARMA
2011 Ligand-gated Ion Channel Symposium, Montreal, Canada, Invited Symposium
speaker
2011 Medical College of Wisconsin, Department of Biophysics
2012 Biophysical Society Annual Meeting, Chair and Organizer of Minisymposium on
“Ligand-gated Ion Channels”.
2012 The University of Texas Medical School, Center for Membrane Biology
2013 Gordon Research Conference on Inhibition in the CNS, Invited Panel Speaker
2013 Morani College of Medicine, University of South Florida, Mol. Pharmacol. and
Physiol. Department
2013 Texas Tech University Health Sciences Center, Lubbock, TX, Department of Cell
Physiology and Molecular Biophysics
2014 Gordon Research Conference on Ion Channels, Invited Panel Speaker
2014 Frontiers in Membrane Protein Structural Dynamics Conference, Chicago, IL,
Invited Speaker
2014 Dart Neuroscience, San Diego, CA, Invited speaker
2014 Barrow Neurological Institute, Phoenix, AZ, invited speaker
2015 9th IBRO World Congress, Rio de Janeiro, Brazil, invited speaker
2015 Polish Neuroscience Society Congress, Gdansk, Poland, invited speaker
2016 Biophysical Society Annual Meeting, Speaker and Co-chair, Ligand-gated Ion
Channel Session
Czajkowski CV
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2016 UCSD, invited speaker
2016 10th Conference on Electrophysiological Techniques: From Ion Channels to
Neural Networks Krakow, Poland, invited speaker
2017 Biophysical Society - Emerging Concepts in Ion Channel Biophysics Mexico City,
Mexico, invited speaker
2017 Case Western Reserve University - Dept. of Physiology and Biophysics, invited
speaker
UNIVERSITY OF WISCONSIN PRESENTATIONS
1994 MD/PhD training program
1994 Neuroscience training program
1996 MD/PhD training program
1996 Department of Neurophysiology
1997 Promega - Second UW Madison Neuroscience Retreat, invited speaker
1997 Chemistry and Biology Interface Training Program
1997 Department of Pharmacology
1998 UW/HHMI 1998 Summer Conference: New Approaches to Membrane Protein
Structure and Function: Invited Speaker.
1999 Life Sciences Careers Day, invited speaker
2000 Department of Physiology
2001 MD/PhD training program
2005 Department of Physiology
2014 Department of Neuroscience
EXTRAMURAL RESEARCH SUPPORT - ACTIVE
1. Agency: NIH, NINDS (NS34727-16)
Role: Principal Investigator
Dates: 03/01/13 – 02/28/2017
Award: $325,000.00/ year (total direct costs)
Title: Structure of the GABAA receptor binding sites.
2. Agency: NIH/NINDS
Type: R21 - NINDS
Period: 12/01/2016 - 11/30/2018
Award: $ 275,000 direct costs
Submitted: Feb. 2016
Review Date: June 2016
Title: Endogenous Benzodiazepines in the Brain
EXTRAMURAL RESEARCH SUPPORT - PENDING
1. Agency: NIH, NINDS (NS34727-COMPETITIVE RENEWAL)
Role: Principal Investigator
Czajkowski CV
24
Dates: 03/01/17 – 02/28/2022
Award: $325,000.00/ year (total direct costs)
Title: Pentameric Ligand Gated Ion Channel Activation and Drug
Modulation.
Submitted: July 2016
2. Agency: NIH - NINDS
Type: F31 individual NRSA
Role: mentor for graduate student Jennifer Borchardt
Award: stipend for three years
Submitted: August 2016
EXTRAMURAL RESEARCH SUPPORT - COMPLETED
1. Agency: NIH, NINDS (NS34727)
Role: Principal Investigator
Dates: 03/15/12 - 02/28/2013 (bridge award)
Award: $385,469.00/ year (total direct costs)
Title: Structure of the GABAA receptor binding sites.
2. Agency: NIH, NINDS (NS059854)
Role: Principal Investigator
Dates: 02/15/2008 – 03/31/2013
Award: $218,750.00/ year (total direct costs)
Title: Structural Rearrangements in GABA-A Receptors.
3. Agency: NIH-NINDS predoctoral NRSA Award (F31-NS071995)
Role: Project Director (Elaine Morlock - pre-doctoral recipient)
Dates: 07/01/10 – 06/30/12
Award: $27,2058.00/ year
Title: “Structural elements involved in GABA-A receptor kinetics”
1. Agency: NIH, NINDS (NS34727)
Role: Principal Investigator
Dates: 01/01/08 - 11/30/2011
Award: $218,750.00/ year (total direct costs)
Title: Structure of the GABAA receptor binding sites.
2. Agency: Sepracor (ESRC104)
Role: Principal Investigator
Dates: 08/01/07 – 07/31/10
Award: $342,766.00 (total direct + indirect costs)
Title: Structural requirements for zolpidem and eszopiclone binding to
GABA-A receptors
Czajkowski CV
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3. Agency: NIH, NINDS (NS34727-S)
Role: Principal Investigator
Dates: 09/01/09 - 08/31/2011
Award: $125,000.00/ year (total direct costs)
Title: “ARRA competitive supplement for “Structure of the GABA-A
Receptor Binding Sites”
3. Agency: NIH-NIAAA predoctoral NRSA Award (F31-AA016898)
Role: Project Director (Kelly Christopherson - pre-doctoral recipient)
Dates: 07/01/07 – 06/30/10
Award: $27,2058.00/ year
Title: “Mapping the putative ethanol binding site on 42 GABA-A
receptors”
4. Agency: NSF Graduate Research Fellowship award
Role: Project Director (Valerie Grant - pre-doctoral recipient)
Dates: 09/01/09 – 08/31/12
Award: $30,000/ year
5. Agency: NIH, NINDS (NS34727)
Role: Principal Investigator
Dates: 12/01/03 - 11/30/2007
Award: $250,000.00/ year (total direct costs)
Title: Structure of the GABAA receptor binding sites.
6. Agency: NIH, NIMH (MH66406)
Role: Principal Investigator
Dates: 07/01/02 – 06/30/07
Award: $200,000.00/ year (total direct costs)
Title: Benzodiazepine modulation of GABA-A receptor kinetics
7. Agency: Alcohol Beverage Medical Research Association
Role: Principal Investigator (5% salary)
Dates: 01/01/07 - 12/30/08
Award: $50,000.00/ year (total direct costs)
Title: Mapping the ethanol binding site on 42 GABA-A receptors
8. Agency: NIH-NIMH postdoctoral NRSA Award (MH082504)
Role: Project Director (Dr. Susan Hanson - post-doctoral recipient)
Dates: 09/30/07 – 09/29/09
Award: $49,646.00/ year
Title: “Structural requirements for benzodiazepine modulation of
GABA-A receptors”
9. Agency: NIH, NIGMS, R01
Role: Collaborator (5% salary)
Czajkowski CV
26
Dates: 07/01/02 - 06/30/06
Title: Volatile Anesthetic Actions on Synaptic GABA-A receptors
P.I. Robert A. Pearce, M.D., Ph.D
10. Agency: NIH, NINDS (NS34727)
Role: Principal Investigator
Dates: 12/01/99 - 11/30/03
Award: $190,000.00/ year (total direct costs)
Also received an additional $50,000.00 supplementary equipment
grant
Title: Structure of the GABAA receptor binding sites.
11. Agency: National Alliance for Schizophrenia and Affective Disorders
Role: Project Director
Dates: 9/15/01 - 9/14/03
Title: Mapping The GABA-A receptor: Molecular determination of
binding sites for psychotherapeutic agents
Award: $50,000/year
12. Agency: Epilepsy Foundation of America
Role: Project Director (Feyza Sancar - pre-doctoral recipient)
Dates: 07/01/03 - 06/30/04
Award: $16,000
Title: Role of GABA-A receptors in epilepsy: Characterization of three
mutations in the GABA-A receptor that are linked to human
epilepsy.
13. Agency: Pharmaceutical Research and Manufacturers of America
Role: Project Director (Jessica Holden - pre-doctoral recipient)
Dates : 01/01/01 – 12/31/02
Award: $12,500/ year
Title: “Mapping the GABA binding site on the GABA-A receptor”
14. Agency: NSERC – Canada (Postdoctoral Award)
Role: Project Director (Dr. Glen Newell - post-doctoral recipient)
Dates: 12/1/00 - 12/1/02
Award: $70,000/ 2 years
15. Agency: Burroughs Wellcome Fund
Role: Principal Investigator
Dates: 07/01/96 - 06/30/01
Award: $195,000
Title: Molecular determination of the benzodiazepine and GABA
binding sites of the GABAA Receptor
16. Agency: NIH-NINDS predoctoral NRSA Award
Czajkowski CV
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Role: Project Director (Jeremy Teissere - pre-doctoral recipient)
Dates: 12/1/00 - 12/1/02
Award: $16,000/ year
Title: “Mapping benzodiazepine binding sites on GABA-A receptors”
17. Agency: NIH-NINDS NRSA Award
Role: Project Director (Dr. David Wagner - post-doctoral recipient)
Dates: 3/1/98 - 3/1/01
Award: $24,292.00/ year
Title: “Assembly of GABA-A Receptor Subunits”
18. Agency: NIH, NINDS, R01
Role: Principal Investigator
Dates: 12/01/96 - 11/30/99
Award: $565,940 (total direct costs)
Title: Structure of the GABAA receptor binding sites.
19. Agency: March of Dimes Foundation- Basil O’Conner Award
Role: Principal Investigator
Dates: 02/01/96 - 01/31/98
Award: $80,000
Title: Mapping the GABAA receptor: Molecular determination of
binding sites for psychotherapeutic agents.
20. Agency: Alcoholic Beverage Medical Research Foundation
Role: Principal Investigator
Dates: 06/01/96 - 05/31/98
Award: $79,996
Title: Mapping an alcohol antagonist binding site on the GABAA
receptor.
21. Agency: Epilepsy Foundation of America
Role: Principal Investigator
Dates: 07/01/96 - 06/30/97
Award: $29,983
Title: Molecular Recognition of Anti-Epileptic Drugs.
22. Agency: NIH-NINDS predoctoral NRSA Award (F31-NS071995)
Role: Project Director (Elaine Morlock - pre-doctoral recipient)
Dates: 07/01/10 – 06/30/12
Award: $27,2058.00/ year
Title: “Structural elements involved in GABA-A receptor kinetics”
INTRAMURAL RESEARCH SUPPORT – ACTIVE
Czajkowski CV
28
1. Agency: UW-Madison (Office of the Provost and SMPH Dean’s office)
Role: Awardee
Dates: 7/1/2012 - 6/30/2017
Award: $75,000 (total) funding is distributed throughout the award period
Title: Vilas Distinguished Achievement Professor
2. Agency: UW-Madison - WISELI
Role: Awardee
Dates: 07/01/2015 - 06/30/2016
Award: $40,000
Title: Vilas Life Cycle Professorship
3. Agency: UW-Madison - Graduate School Fall Competition
Role: Awardee
Dates: 07/01/2016 - 6/30/2017
Award: $48,414.00
Title: Structural basis of benzodiazepine recognition
INTRAMURAL RESEARCH SUPPORT - COMPLETED
1. Agency: UW-Madison School of Medicine/Howard Hughes Medical
Institute
Role: Faculty Investigator
Dates: 11/01/99 - 11/31/01
Award: $30,000
Title: UW/HHMI Program in Molecular Mechanisms of Disease – Pilot
Project
2. Agency: UW-Madison School of Medicine/Howard Hughes Medical
Institute
Role: Faculty Investigator
Dates: 03/01/96 - 12/31/97
Award: $50,000
Title: UW/HHMI Career Development Program in Molecular
Mechanisms of Disease
3. Agency: Univ. of Wisconsin Foundation – Graduate School
Role: Principal Investigator
Dates: 07/01/96 - 06/30/97
Award: $15,750
Title: Fundamental studies of the GABAA receptor.
4. Agency: Univ. of Wisconsin Foundation – Graduate School (WARF)
Role: Principal Investigator
Dates: 07/01/07 - 06/30/08
Award: $34,266
Czajkowski CV
29
Title: Structural Rearrangements in GABA-A receptors
5. Agency: University of Wisconsin - School of Medicine and Public
Health
Role: Principal Investigator
Dates: 07/01/07 - 06/30/08
Award: $23,470
Title: Structural Rearrangements in GABA-A receptors
6. Agency: University of Wisconsin – MERC - WID
Role: Collaborator
Dates: 07/01/07 - 06/30/09
Award: $9,191.00/yr
Title: A novel method for high-throughput drug screening of ligand-
activated ion channels based on tethered ligand force measurement
SERVICE – UNIVERSITY
2016 - 2019 Member, Academic Planning Council, UW - Graduate School (meets
monthly)
2013 - 2017 Member, UW – Graduate Faculty Executive Committee (meets monthly -
conducts and approves graduate program reviews, approves new graduate
programs, reviews and decides graduate student learning goals, stipends)
2016 - 2019 Member, Space Committee, UW - SMPH (meets monthly)
2016 - Peer Mentor, faculty mentor for new Assistant Professor, Darci Moore,
Department of Neuroscience, UW-SMPH
2016 - 2017 Faculty Coordinator, Department of Neuroscience Fall and Spring
Seminar Series
2016 Member, Search Committee, Associate Dean of UW - Graduate School
2015 - 2016 Member, Department of Neuroscience, Faculty Search Committee
2014 Member, Basic Sciences Strategic Planning Committee in UW-SMPH
2013 - 2016 Member, Neuroscience Training Program Steering Committee
2013, 2015 Member, UW – Internal Review Committee - Brain Research Foundation
Grants
2012 – 2013 Member, UW - Faculty Consultative Committee on Financial Emergency
2010 – 2013 Member, UW-Biological Sciences Tenure Committee
2013 Member, Post-tenure review committee (Bill Chiu)
2013 Chair, Physiology Graduate Program Prelim Committee
2012 Member, Physiology Graduate Program Prelim Committee
2012 Member, Post-tenure review committees (June Dahl and Lea Ziskind
Conhaim)
2012 Member, Review Committee Endocrinology & Reproductive Physiology
Program
2011 - 2012 Member, Search Committee for Department of Biomolecular Chemistry
Chair
2011 – 2013 Member, Department of Neuroscience, Task Force Committee
2011 Member, Department of Neuroscience, Tenure Guideline Committee
Czajkowski CV
30
2009 – 2012 Member, Graduate Admissions Committee, Neuroscience Training
Program
2009 Member, Basic Science Department Restructuring in UW-SMPH Task
Force
2009 – 2010 Member, Faculty Search Committee, Department of Physiology
2009 – 2011 Member, Dept. of Physiology Awards Committee
2009 Member, C06 Construction Grant Leadership Group, co-wrote grant
proposal to NIH for building one floor of WIMRII for neuroscience and
regenerative medicine (grant did not get funded)
2008 Member, Search Committee for Department of Medicine Chair
2008 Member, Search Committee for Dept. Anesthesiology tenure track faculty
2006 – 2012 Chair, faculty mentoring committee for Dr. Baron Chanda, Physiology
Dept.
2006 – 2009 Member, University of Wisconsin - Medical Education and Research
Committee
2006 – 2007 Member, Search Committee for Chair of Anesthesiology Department
2005 - 2006 Acting Chair, Neuroscience Training Program
2005 Member, Campus Review Panel for the Searle Scholars Program
2004, 2005 Member, Faculty Search Committee, Department of Physiology
2004 – 2012 Member, Fellowship Committee, Molecular and Cellular Pharmacology
Training Program
2003 – 2006 Member, Carnegie Initiative on the Doctorate
2003 – 2016 Member, Jerzy Rose Neuroscience Award committee
2003 - 2004 Member, Strategic Planning Committee for the Medical School –
Research Subcommittee
2001 – 2004 Member, UW - Graduate School Research Committee. This committee
reviews and decides on the funding of research proposals from
investigators in the biological sciences and selects University
Distinguished Professorships (Romnes, Kellett Mid-Career, and WARF
Professorships for the Biological Sciences).
2000 – 2007 Member, faculty mentoring committee for Dr. Matt Jones, Dept. of
Physiology
2002 – 2010 Member, affiliate faculty appointment committee, Dept. of Physiology
2001 – 2004 Member, fall seminar series committee, Dept. of Physiology
2000 – 2006 Member, executive committee, Neuroscience Training Program
1999 – 2002 Chair, Graduate Admissions and Recruiting Committee, Neuroscience
Training Program
1996 – 2002 Member, Steering Committee, Molecular and Cellular Pharmacology
Training Program
1996 - 2001 Faculty Senator for Department of Physiology
1999 – 2001 Member, 1st year advisory committee, Neuroscience Training Program
1999 Member, Graduate Admissions Committee, Molecular and Cellular
Pharmacology Training Program
1998 Member, Faculty Search Committee, Department of Physiology
1997 - 1998 Member, Organizing Committee, UW/HHMI 1998 Summer Symposium
on Membrane Proteins
Czajkowski CV
31
1997 Member, Graduate Admissions Committee, Department of Physiology
1996 - 1997 Member, Graduate Admissions Committee, Neuroscience Training
Program
1996 – 1997 Co-chair, Graduate Admissions Committee, Molecular and Cellular
Pharmacology Training Program
1994 - pres Faculty Trainer: Biophysics Training Program, Cell & Molecular Biology
Training Program, Chemistry/Biology Interface Training Program,
MD/PhD Training Program, Molecular Biosciences Training Program,
Molecular and Cellular Pharmacology Training Program, Neuroscience
Training Program, Physiology Training Program
SERVICE – NATIONAL and INTERNATIONAL
Review Boards and Study Sections
1) NIH Study Section MDCN3/BSCT (Oct. 1999 – June 2004) full-time member
2) Canadian Institutes of Health Research grant reviewer (Nov. 2004)
3) NSF grant reviewer (May 2001)
4) NIH Study Section (special review committee) Dec 1999
5) NIH–NIGMS Special Emphasis Panel (1998) Member of site-visit and review of
program project grant on volatile and general anesthetics
6) NIH–NIAA Special Review Committee (1998) Member of site-visit and review of an
alcohol research center grant
7) NIH–NIGMS Special Emphasis Panel (1997) Member of site-visit and review of a
center grant on volatile and general anesthetics
8) NIH Study Section - Special Emphasis Panel (July 2007)
9) NIH Study Section - Special Emphasis Panel (ZRG1 MDCN-C (02) Feb. 2009) –
Chair
10) NIH Study Section – BPNS – June 2009 – adhoc member
11) Biotechnology and Biological Sciences Research Council (UK) – grant reviewer
9/2010
12) NIH Study Section – Chair - Special Emphasis Panel (ZRG1 MDCN-N (02) Oct.
2010
13) Wellcome Trust (UK) – grant reviewer 12/2011
14) NIH Study Section – Special Emphasis Panel (2012) review of a center grant on
volatile and general anesthetics
15) Wellcome Trust (UK) – grant reviewer 2/2012
16) Research Foundation – Flanders (FWO) – Belgian – grant reviewer 9/2012
17) Institut Pasteur – France – grant reviewer 11/2012
18) Biotechnology and Biological Sciences Research Council (BBSRC) – UK – grant
reviewer 1/2013
19) Austrian Science Fund – grant reviewer – 3/2013
20) Research Council - University of Leuven, Belgium – grant reviewer – 3/2013
21) NIH Study Section – Special Emphasis Panel (2013) reviewer for grants submitted in
response to Exceptional Unconventional Research Enabling Knowledge Acceleration
(EUREKA) for Neuroscience and Disorders of the Nervous System (R01)
announcement.
Czajkowski CV
32
22) Neurological Foundation of New Zealand - grant reviewer 11/2013
23) NIH Study Section - Reviewer- PPG on mechanisms of anesthesia 3/2014
24) MRC (UK) - grant reviewer 4/2014
25) NIH Study Section - Reviewer - Study section panel phone reviewer 6/2014
26) NIH Study Section - Reviewer - R13 Conference Review panel 2/2015
27) NIH Study Section - Reviewer - pre and postdoctoral NRSAs 11/2016
Editorships
2007 – 2013 Associate Editor – Journal of Neuroscience
2010 – pres Editorial Board – Biophysical Journal
2014 - pres Editorial Board - Journal of General Physiology
Consultant
1) Neurion Pharmaceutical, Pasedena, CA (August 2003 – 2006)
2) Sepracor (2006-2008)
3) Ironwood Pharmaceuticals (2013 – 2015)
Board Memberships:
1) Advisory Board Member - Biophysical Society - Institute of Physics Publishing
Manuscript Reviewer – Reviewer for the following journals: Nature, Nature
Neuroscience, Nature Communications, Nature Structural Biology, Neuron, Journal of
Neuroscience, Molecular Pharmacology, Journal of Biological Chemistry, Journal of
Neurochemistry, Biophysical Journal, Biochemistry, Journal of General Physiology,
PNAS, FASEB J, EMBO J, Journal of Physiology, Plos Biology, Plos One, British
Journal of Pharmacology, e-Life.