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Optical fiber sensors for medical applications Research activities at University of Limerick
[Jiliang University, 10 Dec 2013]
Daniele Tosi
www.ofsrc.ul.ie
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
AboutUniversity of LimerickOptical Fibre Sensors Research Centre[Marie Curie Fellow @ OFSRC]
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Partnerships
UL, OFSRCPointec (licensing)Cleveland Clinic
EFPI cardiovascular/demo
Johns HopkinsRobotic surgery
Partners ItalyPolitecnico di Torino (FBG)Federico II Napoli (urodynamic)Universita’ di Pavia (RFA)Politecnico di Milano (RFA)LunaTEC
Cyprus IT (EFPI partner)
ShenzhenCustom catheters supplier
Harbin Inst. Technol.Staff exchange partnership
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Outline➡ Optical fiber sensors: properties and technology‣EFPI - pressure, temperature, refractive index‣Fiber Bragg grating (FBG), DTG, LPG‣Sensor integration and interrogation‣Catheterization
➡ Emerging applications in medical/biomedical‣Cardiovascular, FFR, IABP‣Urodynamics‣Monitoring of radiofrequency thermal ablation‣Robotic surgery tools
➡ Conclusions
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
OFS properties
Top-notch Performance
Miniature size
Distribution and Integration
Immunity
➡ Excellent sensitivity to press., temp., strain➡ <1με, 0.01˚C, <10Pa resolution➡ Cross-sensitivity abating/compensation
➡ Miniature size (∅125μm, ∅40μm custom)➡ Lightweight, non-invasive, embeddable➡ Versatile fiber coating and catheterization
➡ Punctual sensors➡ Multiplexed, switched, quasi-distributed➡ Integration (lab in a fiber)
➡ Immune to EMI, radiation, MRI➡ Fire-safe, passive device➡ No interference with existing equipment
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
EFPIEFPI: Fiber-optic Fabry-Perot interferometric sensor based on all-silica glass structure: (1) launch fiber, (2) diaphragm, (3) capillary
Capillary
Launch SM fiber
Diaphragm MM fiber
AIR-GAP
(optionalFBG)
Single-mode fiberA
ir-ga
pD
iaph
ragm
Capillary
Ld
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
UL EFPI (pre-etch)
L = 20.6μm
Air-gap length LFP Spectrum ~ S0 + k cos[4πL/λ]
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
UL EFPI (pre-etch)
Pressure
Air-gap length L = L0 - Sp ΔPFP Spectrum ~ S0 + k cos[4π(L - Sp ΔP)/λ]Temperature: L = L0 - Sp ΔP + ST ΔT ⇒ FBG
L0 - Sp ΔP
L
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
UL EFPI (pre-etch)
Sp = 1.60 nm/kPa
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Commercial EFPIEFPI head: 200µm
Encapsulation: 500µm Input fiber: 125µm
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Commercial EFPI
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Pressure detectionRMSE = 2.29 mmH2O
RMSE = 1.30 mmH2O
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Pressure detectionRMSE = 2.29 mmH2O
RMSE = 1.30 mmH2O
RMSE = 2.29 mmH2O = = 0.21 mmHg
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Improved detection
D. Tosi, S. Poeggel. G. Leen, E. Lewis, “Adaptive filter-based interrogation of high-sensitivity fiber optic Fabry-Perot interferometry sensors,” Sensors and Actuators A: Physical, in press
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Fiber Bragg grating (FBG)
FBG = fiber optic filterFBG cascade ⬌ Multiplexing
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Fiber Bragg grating (FBG)
•Information encoded in FBG optical spectrum•Linear dependance on strain and temperature•Top performance sensor•Easy interrogation
Reflected Bragg wavelength shifts linearly with variation of tensile strain and temperature
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Fiber Bragg grating (FBG)Strain + temperature encoded in the sensing element
Strain: can be converted into force, by packageTemperature: for sensing, and compensation
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Draw-tower grating
IOS hypertermia sensor: 5 FBG in 3 cm
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Long period grating (LPG)
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
EFPI/FBG
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
EFPI/FBG
Δλ(ΔT, ΔP)
ΔL(ΔT,ΔP)
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Detuning: 0.03 kPa/°C
-96% glass-99.6% mould
Cross-sensitivity
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
White light setup
...
...
...
.
.....
.
..
Switch
SLED
FBGA
Courtesy of Politecnico di Torino
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
White light setup
...
...
...
.
.....
FBG matrix
.
..
Switch
SLED
FBGASwitch Circulator
SLED
FBGA
Courtesy of Politecnico di Torino
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Coherent light setupCourtesy of Politecnico di Torino
Switch
Laser array
Laser controller
Photodiode
...
...
...
.
.....
FBG matrix
.
..
Coherent light setup
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
...
...
...
.
.....
FBG matrix
.
..
Switch
Laser array
Laser controller
Photodiode
Laser PhotodiodeTEC
Circulator SwitchCourtesy of Politecnico di Torino
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Interrogation
White light Coherent light
Encoding
Resolution
Throughput
Switching
# Sensors
Cost (box)
Stability
Wavelength Amplitude
1 pm (150 pm) << 1 pm
1-100 Hz total >kHz/channel
1/N * W 1/(N*W)
2-50/channel <10
$12k $2.5k
Excellent Low
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Further integration
➡ Lab in a fiber‣Integration of several sensing units in a single fiber‣FBG (array), LPG, EFPI + bio/chemical (SPR)
➡ Quasi-distributed‣Dense monitoring of parameters, localized‣Bundle of EFPI, array of FBG, combination EFPI/FPI
➡ Cross-compensation‣Sensing parameter + temperature + ref. index‣Compensation matrix, detuning
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Pigtail catheter
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Pigtail catheter
4F
French(F) = 1/3mm
Contrast liquid
Excess bending
2x probes (distal)
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Foley catheter
Urology catheter, bi-sex
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Foley catheter
FO
1cm
4F
Side holes allow infusionInfusion + uroflowmetry
Seal: epoxy or medical tape
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Needle/trocar
Radiofrequency ablation needle
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Needle/trocar(1) Insert FO probe/bundle, retracted
(2) Expand/block into position
(optional: cut needle arms to desired length)
(3) Push and project fibersTrocar provides blockage
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Cardiovascular
Top-notch Performance
Miniature size
Distribution and Integration
Immunity
➡ Excellent sensitivity to press., temp., strain➡ ➡
➡ Miniature size (∅125μm, ∅40μm custom)➡ Lightweight, non-invasive, embeddable➡ Versatile fiber coating and catheterization
➡ Punctual sensors➡ Multiplexed, switched, quasi-distributed➡
➡ Immune to EMI, radiation, MRI➡ ➡ No interference with existing equipment
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Cardiovascular➡ Blood pressure monitoring
‣Localized: allows localizing the phenomena without
damping, spatial averaging, fluid transfer (walls)
‣Multi-sensor: 2x sensors for obstructions (FFR)
‣Requires high speed: 100 Hz hardware to detect pulse
‣Used in the study of vasodilators/vasoconstrictors,
localize the pressure effect (pilot project)
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Fractional Flow Reserve
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Fractional Flow Reserve2x optical fiber pressure
sensors allow direct detection of FFR, pre-
and post-sthenosis
Problems in long-term:- Drift: >5 mmHg/hr - Temperature compensation- Amplitude drifts
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Intra-aortic balloon (IAB)
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Fiber-optic IAB
Fiber-optic cable
Pressure detection
FO selling points:- better stability to patients movements- better reproduction of pulse peak
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Setup phantomHeart simulator
Interrogator/processing
Heart pumping
Sensor positioning(short access)
EFPI spectrum
Pressure meas.
SpectrometerASE source
Heart pumpinginletFiber inlet
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Cardio phantom
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Stability (1 hr)
0 10 20 30 40 50 60
62.5
63
63.5
64
64.5
65
Time (min)
Pres
sure
(mm
Hg)
EFPIFluidic
0.63 mmHg
2.76 mmHg
Typical FO drift ~ 5 mmHg/hr. St. Jude drift: 4mmHg/10min
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Ventricular assistDemonstration at Cleveland Clinic, Mar 2013
FPI positioning
Ventricular assist
Reference (fluidic)Pressure readout
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Ventricular assistDemonstration at Cleveland Clinic, Mar 2013
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Urodynamic
Top-notch Performance
Miniature size
Distribution and Integration
Immunity
➡ ➡ ➡
➡ Miniature size (∅125μm, ∅40μm custom)➡ Lightweight, non-invasive, embeddable➡ Versatile fiber coating and catheterization
➡ Punctual sensors➡ Multiplexed, switched, quasi-distributed➡
➡ ➡ ➡ No interference with existing equipment
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Urodynamic“Standard” invasive urodynamics: Mid-term (20-40 minutes) monitoring of the detrusor muscle pressure and flowmetry during a urology analysis that consists of infusion and voiding of the bladder
Why fiber-optic: - FO sensors have a better responsivity and lower damping than air-charged catheter- It is possible to fit multiple fibers in the bladder: change the way bladder obstructions are diagnosed
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Urodynamic
Diagnostic based on nomogram: detrusor pressure vs uroflowmetry➡ Direct detection of bladder outlet obstruction (BOO)
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
In-vivo measurementInfusion (375ml) Urination
EFPI
Pico2000
Feasibility test with Federico II University, Naples.
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
In-vivo measurementFeasibility test with Federico II University, Naples.
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
In-vivo measurement
CoughStimulus
Urination
Feasibility test with Federico II University, Naples.
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Direct BOO (proposal)
InterrogatorDifferential pressure measurementBladder outlet obstruction (BOO) diagnostic
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
RF ablation of tumors
Top-notch Performance
Miniature size
Distribution and Integration
Immunity
➡ ➡ ➡ Cross-sensitivity abating/compensation
➡ Miniature size (∅125μm, ∅40μm custom)➡ Lightweight, non-invasive, embeddable➡ Versatile fiber coating and catheterization
➡ ➡ Multiplexed, switched, quasi-distributed➡ Integration (lab in a fiber)
➡ Immune to EMI, radiation, MRI➡ Fire-safe, passive device➡ No interference with existing equipment
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
RFA descriptionRadiofrequency thermal ablation (RFA):Achieving the complete ablation of a cancerous tumor by burning the tumor + surrounding by means of Joule effect. In RFA the heat field is generated through 5-50W RF
Tumor, up to 5cm size
Needle, 1mm diameter
Ablation, ~15min/cm
RF field
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
RFA in liverLiver tissue sets a specific problem: ebullience releases the watery part of cells, which conduct more than liver - the RF circuit is disconnected after 2-9 minutes
➡ Not possible for RFA to remove mid/large tumors, over 2 cm in diameter➡ RFA is performed at ~60˚C rather than >100˚C. Cells mortality not guaranteed➡ Need to resort to microwave ablation (MWA)➡ Biocompatible gels can isolate needle from ebullient cells
Numbers: 764k deceases (#3)
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Heat distributionIR thermal camera - imaging
Is the model confirmed by localized sensors?Is it possible to increase RFA efficiency/duration?
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Heat distributionIR thermal camera - imaging
Is the model confirmed by localized sensors?Is it possible to increase RFA efficiency/duration?
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Ex-vivo - setupExperiments with Universita’ di Pavia, San Matteo Hospital, Politecnico di Milano
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Ex-vivo experimentsExperiments with Universita’ di Pavia, San Matteo Hospital, Politecnico di Milano
8mm
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Ex-vivo experimentsExperiments with Universita’ di Pavia, San Matteo Hospital, Politecnico di Milano
5mm
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Ex-vivo experimentsExperiments with Universita’ di Pavia, San Matteo Hospital, Politecnico di Milano
1mm
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Preliminary conclusionsThe preliminary results obtained with EFPI/FBG do not match the physical model, nor the thermal camera imaging.
We observe during ablation a higher temperature, and higher pressure than expected (105˚C and 80 kPa).
Denser monitoring is needed to have a full reproduction of the physical phenomena.
Is it possible to increase the RFA efficiency, by online monitoring of pressure/temperature field?
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Robotic surgery
Top-notch Performance
Miniature size
Distribution and Integration
Immunity
➡ Excellent sensitivity to press., temp., strain➡ <1με, 0.01˚C, <10Pa resolution➡ Cross-sensitivity abating/compensation
➡ Miniature size (∅125μm, ∅40μm custom)➡ ➡
➡ ➡ Multiplexed, switched, quasi-distributed➡ Integration (lab in a fiber)
➡ Immune to EMI, radiation, MRI➡ ➡
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Robotic surgery•Integration of miniature FO sensors in surgical tool
•Measurement of force: 3D lateral + axial, return haptic
•Microsurgery (vitreoretinal surgery).
•Size matter! <125μm attractive, 40μm fibers for animal...
Da Vinci surgical tool: insufficient resolution to address microsurgery procedures. Need for a surgical tool that embeds sensors with <mN force detection + temperature compensation, to return a haptic feedback to the doctor.
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Tool shafts
X. Liu, I. Iordachita, X. He, R. T. Taylor, J. U. Kang, “Miniature fiber-optic force sensor based on low-coherence Fabry-Perot interferometry for vitreoretinal microsurgery,” Biomedical Optics Express, v. 3, n. 5, 2012
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Robotic surgery sensors
•Two alternative technologies: EFPI, FBG
•FBG in a spring configuration, to translate force to strain
•Low sensitivity: 10 mN ⇢ 1 pm (1με)•It needs temperature compensation
•EFPI promising, but larger size
•Transfer of axial forces through the capillary
•Proposal: all-EFPI configuration, axial+lateral+temperature
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Conclusions➡ Optical fiber sensors are well on their way to address
medical opportunities, usually in multiB markets➡ Research emphasis on multi-sensing structures: lab-in-a-
fiber, quasi-distributed, dense monitoring➡ Scalability is a key factor for transitioning from lab to
market, but compatibly with disposable cost➡ Emerging applications raise the bar for sensing
complexity: size, integration, mechanical prop., catheters➡ Biocompatibility is a key issue: prevalence of all-glass
structures, most packages not FDA-compliant!
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
Acknowledgments‣ Federico II University - Urologic Clinic
‣ Universita’ di Pavia, Politecnico di Milano
‣ Cleveland Clinic
‣ FP7 Marie Curie (299985-PROBESENSE)
‣ Science Foundation Ireland (RFP/ECE2898)
‣ Enterprise Ireland (IP-2012-0166-Y)
‣ University of Limerick, MSSI and CES depts.
Daniele Tosi - Optical fiber sensors for medical applications - Research activities at University of Limerick
➡ Cooperation➡ Partnerships➡ Funding proposals... are welcome...
Thank you - Xie xie