Darren Benjamin Orbach, MD PhD Curriculum Vitae Date Revised: February 4, 2019 Name: Darren Benjamin Orbach, MD PhD Office Address: Boston Children’s Hospital Neurointerventional Radiology 300 Longwood Avenue Boston, MA 02115 Work Phone: 617-355-5012 Work Email: [email protected]Work FAX: 617-730-0382 Place of Birth: Brooklyn, NY Education Year Degree Honor Institution 1989 BA Philosophy (cum laude) Princeton University 1997 PhD Biophysics & Neurophysiology (mentor: Ehud Kaplan) Rockefeller University 1998 MD Medicine Cornell University Medical College Postdoctoral Training Years Title Specialty/Discipline Institution 07/1998- 06/1999 Internship Neurology/Radiology/ Neuroradiology Training Program NYU Medical Center 07/1999- 06/2001 Residency (Neurology) Neurology/Radiology/ Neuroradiology Training Program NYU Medical Center 07/2001- 06/2003 Residency (Diagnostic Radiology) Neurology/Radiology/ Neuroradiology Training Program NYU Medical Center 07/2003- 06/2005 Fellowship (Diagnostic and Interventional Neuroradiology) Neurology/Radiology/ Neuroradiology Training Program NYU Medical Center 07/2005- 06/2006 Fellowship Neurointerventional Radiology NYU Medical Center
Transcript
Darren Benjamin Orbach, MD PhD Curriculum Vitae
Date Revised: February 4, 2019
Name: Darren Benjamin Orbach, MD PhD
Office Address: Boston Children’s Hospital Neurointerventional Radiology 300 Longwood Avenue Boston, MA 02115
1998 MD Medicine Cornell University Medical College
Postdoctoral Training Years Title Specialty/Discipline Institution 07/1998- 06/1999
Internship Neurology/Radiology/ Neuroradiology Training Program
NYU Medical Center
07/1999- 06/2001
Residency (Neurology) Neurology/Radiology/ Neuroradiology Training Program
NYU Medical Center
07/2001- 06/2003
Residency (Diagnostic Radiology)
Neurology/Radiology/ Neuroradiology Training Program
NYU Medical Center
07/2003- 06/2005
Fellowship (Diagnostic and Interventional Neuroradiology)
Neurology/Radiology/ Neuroradiology Training Program
NYU Medical Center
07/2005- 06/2006
Fellowship Neurointerventional Radiology NYU Medical Center
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Faculty Academic Appointments Years Academic Title Department Academic Institution 2005-2006 Clinical Assistant Professor Radiology NYU School of Medicine
2006-2012 Assistant Professor Radiology Harvard Medical School
2012-Present Associate Professor Radiology Harvard Medical School
Appointments at Hospitals/Affiliated Institutions Years Position Title Division/Department Institution
2012-2015 Member, Clinical Events Safety Committee, Data Safety Management Board
THERAPY Trial: Randomized, Concurrent Controlled Trial to Assess the Penumbra System’s Safety and Effectiveness in the Treatment of Acute Stroke, Penumbra, Inc.
2013-2016 Member, Clinical Events Safety Committee, Data Safety Management Board
Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms, Penumbra, Inc.
2015-Present Medical Advisory Board PHACE Syndrome Community
Major Administrative Leadership Positions Local Years Position Title Institution 2009-Present Director of Interventional
Neuroradiology Boston Children’s Hospital
2010-2017 Division Chief, Interventional Radiology Boston Children’s Hospital
2014-Present Co-Director, Cerebrovascular Surgery & Interventions Center
Boston Children’s Hospital
2017-Present Chief, Interventional Neuroradiology Boston Children’s Hospital
Committee Service Local Years of Membership
Name of Committee Dates of Roles
Institution/Organization Title of Roles
2006-2009 Neuroscience Research Imaging Service Line Committee
Brigham and Women’s Hospital
2010-Present Member, Board of Directors Radiology Foundation, Boston Children’s Hospital
2016-Present Member, Stroke Events in Patients Mitigation Committee
Boston Children’s Hospital
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Professional Societies Years of Membership Society Name Dates of Roles Title of Roles
2001-Present American Academy of Neurology Junior Member
2003-Present New York Roentgen Society Associate Member
2005-Present American Society of Neuroradiology Member
2006-Present Senior Member
2011-2013 Member, ASNR Research Committee
2006-Present American College of Radiology Member
2007-Present Society for Neurointerventional Surgery Senior Member
2015 Member, Program Committee for the 2016 SNIS Annual Meeting
2008-Present International Society for the Study of Vascular Anomalies
Member
2010-Present World Federation of Interventional and Therapeutic Neuroradiology
2013-2015 WFITN Congress Plenary Session Moderator, Pediatric Neurointerventions (2015)
2013-Present Executive Committee Member
2015-Present Treasurer
2015-2017 WFITN Congress Plenary Session Moderator & Program Director, Pediatric Neurointerventions (2017)
2012-Present American Society of Pediatric Neuroradiology
Member
2015 Radiological Society of North America Member
2015 Refresher Course Moderator, Brain Aneurysms
Editorial Activities Years Journals for which I serve(d) as a reviewer
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Years Journals for which I serve(d) as a reviewer 2002-2005 Ad hoc Reviewer, Epilepsia
2004-Present Ad hoc Reviewer, American Journal of Neuroradiology
2010-Present Ad hoc Reviewer, American Journal of Radiology
2011-Present Ad hoc Reviewer, Journal of Neurointerventional Surgery
2015-Present Ad hoc Reviewer, Interventional Neuroradiology
2016-Present Ad hoc Reviewer, European Radiology
2019-Present Ad hoc Reviewer, Neurographics
Honors and Prizes Year Name of Honor/Prize Awarding Organization
1990 Medical Scientist Training Program MD-PhD Biomedical Fellowship
NIH / The Mellon Foundation
1995 Electrophysiology Section Young Investigator Award NIH / National Eye Institute
2002 Inaugural Fellow Young Presidents’ Organization
2008 Nominee for the Dana Foundation Program in Brain and Immuno-Imaging (eMRI project)
Harvard Medical School
2010 MR Biomarkers for Disease – Assessment of Neurological Disorders (Seed Grant Prize)
International Society for Magnetic Resonance in Medicine / American Society for Neuroradiology
2011 Harvard Medical School Leadership Development Course for Physicians and Scientists (selective admission)
Harvard Medical School
2017 Sage Schermerhorn Endowed Chair in Image-Guided Therapy
Boston Children’s Hospital, Radiology Foundation
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Report of Funded and Unfunded Projects
Funding Information Past Years Grant title
Grant title and number Role on project Description of the major goals
2002-2004 Cerebrovascular Imaging of Stroke Risk AHA EVEREST Research Scholarship Award $10,000 PI The major goal of this project was to develop algorithms for using 3D CT virtual angioscopy to assess patency of implanted carotid artery stents.
2005-2006 Magnetic Resonance Encephalography – Direct MR Imaging of Epileptic Activity NYU Radiology Department Pilot Project $10,000 Grant PI The major goal of this project was to assess the feasibility of using high-speed gradient echo MR imaging to visualize epileptic foci in patients with intractable epilepsy.
2006-2009 Brigham and Women’s Radiology Startup Research Fund $150,000 PI These funds have been directed towards the encephalographic functional Magnetic Resonance Imaging project described below.
2008-2009 Encephalographic Functional Magnetic Resonance Imaging – Direct MR Imaging of Cerebral Electromagnetic Activity Brigham and Women’s Radiology Foundation Award $25,000 PI The major goal of this project is to develop a technique to directly image electromagnetic activity in the brain using simultaneous EEG and high-speed MR acquisition. Patient cohorts being studied include patients with intractable epilepsy as well as normal subjects performing visuomotor tasks and sleeping subjects.
2006-2011 A Phase 1 Study To Evaluate The Safety And Feasibility Of Transcranial MRI-Guided Focused Ultrasound Surgery In The Treatment Of Brain Lesions Insightec, Inc. Coinvestigator The major goal of this study is to investigate the safety and feasibility of using MR-guided ultrasound to treat inoperable brain lesions. My role is to provide neuroradiological guidance in screening potential subjects, performing treatment sessions, and assessing treatment response.
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Years Grant title Grant title and number Role on project Description of the major goals
2009-2012 MR Biomarkers for Disease Assessment of Neurological Disorders Seed Grant $25,000 International Society for Magnetic Resonance in Medicine / American Society for Neuroradiology PI A seed grant competition jointly administered by the International Society for Magnetic Resonance in Medicine and the American Society of Neuroradiology, with a single winner each year. Our submission was entitled Encephalographic Magnetic Resonance Imaging: MR Biomarkers for Epilepsy.
2011-2012 Fast Volumetric MRI for Localizing Electromagnetic Discharges in Pediatric Epilepsy $47,000 Boston Children’s Hospital-MIT Collaborative Grant Program Co-PI (with Elfar Adalsteinsson at MIT) The major goal of this study is to extend eMRI beyond planar acquisition by developing a volumetric mode of acquisition for localizing epileptic discharges in pediatric patients
2011-2014 Thrombolysis in Pediatric Stroke (TIPS) $26,000 (Children’s Hospital subcontract) NIH Coinvestigator An NIH-funded US-Canadian consortium of 20 pediatric facilities to examine the safety and efficacy of intravenous thrombolysis for acute childhood stroke. Boston Children’s Hospital has been selected as the imaging core lab for this study, and I will serve as one of two readers of the associated imaging studies.
2009-2017 Intraarterial Chemotherapy for Retinoblastoma Children’s Oncology Group (Retinoblastoma Subcommittee of the Rare Tumors Committee) Institutional co-PI, Interventional Radiology Expert Committee A phase 1 study to assess the safety and feasibility of intraarterial chemotherapy for pediatric patients with retinoblastoma at 5 centers nationwide
Current Years Grant title
Grant title and number Role on project Description of the major goals
2009-Present Encephalographic MRI Research Fund $150,000 Boston Children’s Hospital Radiology Foundation PI These funds have been directed towards the encephalographic functional Magnetic Resonance Imaging project described below.
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Current Unfunded Projects Years funded Role on Project/Title of Project
Description/Purpose of the project 2016-Present Vascular-Neural Interfaces
MIT (Ed Boyden, PI) / Columbia University Co-investigator, Institutional PI This project has the goal of developing novel miniature and nano endovascular devices designed to directly record and stimulate electrical neuronal activity. First-generation devices are modifications of cerebral stents, with incorporated chip boards that are wirelessly powered and wirelessly transmit, and are capable of multi-unit recording and stimulation; these are being trialled in rabbit and pig animal models for deployment in the distal internal carotid and vertebrobasilar system. Next-generation devices are designed for single-unit recording and stimulation, for deployment in the microvasculature. Such systems may prove to be powerful basic neuroscience tools for measuring brain activity, to have high clinical utility as novel diagnostic and therapeutic tools for epilepsy and movement disorders, and to be instrumental in the development of brain-machine interfaces.
Report of Local Teaching and Training Teaching of Students in Courses Years Course Title Location Type of Student/Audience Level of Effort
2001-2002 Physical Diagnosis: The Neurologic Exam 2nd year medical students
NYU School of Medicine One 3-hr session for 4 weeks
2005 Neuroscience: Neuroradiology 1st year medical students
NYU School of Medicine One 3-hr session for 2 weeks
2007 Fourth-Year Comprehensive Exam (OSCE) (Radiology) 4th-year medical students
Harvard Medical School Two 4-hr sessions
2008 Fourth-Year Comprehensive Exam (OSCE) (Radiology) 4th-year medical students
Harvard Medical School Two 4-hr sessions
Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs) Years Course Title Location Type of Student/Audience Level of Effort 2003-2004 Introduction to Neurology: Neuroimaging
1st – 3rd year neurology residents NYU Medical Center Two 2-hr lectures
2007 Neurosurgery Neurovascular Conference 1st – 7th year neurosurgery residents
Brigham and Women’s Hospital Two 1-hr sessions
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Years Course Title Location Type of Student/Audience Level of Effort
2008 Radiology Noon Conference 1st – 4th year radiology residents
Brigham and Women’s Hospital Two 1-hr sessions
2006-2009 Neurointerventional Case Conference Diagnostic and interventional neuroradiology fellows
Brigham and Women’s Hospital Monthly 1-hr session
2009 Pediatric Neurovascular Disease 1st – 3rd year neurology residents
Boston Children’s Hospital One hour lecture
2010 Neuroradiology Fellows’ Conference Boston Children’s Hospital One hour lecture
2009-Present Neurointerventional Case Conference Diagnostic and interventional neuroradiology fellows
Boston Children’s Hospital Monthly 1-hr session
2010-Present Immersion in the Neuroangiography Suite – A weekly rotation providing the diagnostic neuroradiology fellow at Boston Children’s Hospital in-depth, real-time exposure to the neurointerventional management of cerebrovascular disease
Boston Children’s Hospital Weekly 3-hr session
2011 Radiology Fellows and Residents’ Friday Conference – Didactic Case Conference in Pediatric Neurovascular Disease
Boston Children’s Hospital One 1-hr session
2012 Radiology Fellows and Residents’ Morning Conference – Neurointerventional Management of Acute Ischemic Stroke in Children
Boston Children’s Hospital One 1-hr session
2013 Radiology Fellows and Residents’ Morning Conference – Radiation Risks to Children from Neurointerventions
2014 Radiology Fellows and Residents’ Morning Conference – Syndromic Vascular Malformations of the Spine
Boston Children’s Hospital One 1-hr session
2014 Radiology Fellows and Residents’ Morning Conference – Vascular Malformations of the Spine.
Boston Children’s Hospital One 1-hr session
2014 Radiology Fellows and Residents’ Morning Conference – Intro to Neurovascular Interventions in Children
Boston Children’s Hospital One 1-hr session
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Years Course Title Location Type of Student/Audience Level of Effort
2015 Noon Conference for Radiology Fellows and Residents – Pediatric CNS Vascular Anomalies
Boston Children’s Hospital One 1-hr session
2016 Medical/Surgical Intensive Care Unit Fellows - Interventional Neuroradiology Management of AIS in Children
Boston Children’s Hospital One 1-hr session
Clinical Supervisory and Training Responsibilities Years Type of Responsibility Location 2005-2006 Supervision and instruction in cerebral angiography
of diagnostic neuroradiology fellows, diagnostic radiology residents and neurosurgery residents
NYU Medical Center
2006-2009 Daily clinical supervision and teaching of one-month rotations for diagnostic neuroradiology fellows, as well as elective rotations for neurology and neurosurgery residents
Brigham and Women’s Hospital
2009-Present Weekly supervision of the pediatric interventional radiology fellow at Boston Children’s Hospital, in performing neurointerventional cases
Boston Children’s Hospital
Laboratory and Other Research Supervisory and Training Responsibilities Year(s) Type of Responsibility Level of Effort 2006 – present Supervision of neuroradiology fellow
retrospective clinical neurovascular research Biweekly to monthly progress assessment sessions
2008 Supervision of undergraduate retrospective clinical neurovascular research
Biweekly to monthly progress assessment sessions
2008 – 2015 Supervision of post-doctoral research fellows Multiple weekly meetings, quarterly assessment of progress
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Formally Supervised Trainees Mentored Clinical Fellows Years Name and degrees / Current position
2006-2007 Huan Wang, MD / Assistant Professor of Neurosurgery University of Illinois at Urbana-Champaign Clinical Fellow Supervision of neurointerventional radiology clinical fellowship, published two manuscripts and one book chapter
2007-2009 Ruth Thiex, MD PhD / Assistant Professor of Neurosurgery at University of Washington at Seattle Clinical Fellow Supervision of neurointerventional radiology clinical fellowship, published several manuscripts and one book chapter, presented several abstracts at national meetings
2008-2010 Ajit Puri, MD Clinical Fellow Supervision of neurointerventional radiology clinical fellowship, published several manuscripts and one book chapter, presented several abstracts at national meetings
2009-2011 Hekmat Zarzour, MD Clinical Fellow Supervision of neurointerventional radiology clinical fellowship, published one book chapter
2010-2011 Ning Lin, MD Clinical Fellow Supervision of endovascular neurosurgery clinical fellowship, published several manuscripts, presented abstracts at several national meetings
2011-2012 Stephen Nalbach, MD Clinical Fellow Supervision of endovascular neurosurgery clinical fellowship
2011-2013 Ayca Akgoz, MD Clinical Fellow Supervision of neurointerventional radiology clinical fellowship, published several manuscripts
2011-2013 Bradley Gross, MD Clinical Fellow Supervision of endovascular neurosurgery clinical fellowship, published several manuscripts
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Years Name and degrees / Current position 2013-2014 Abhishek Agrawal, MD
Clinical Fellow Supervision of endovascular neurosurgery clinical fellowship, published a textbook chapter
2013-2014 Sachin Pandey, MD Clinical Fellow Supervision of endovascular neurosurgery clinical fellowship, published a textbook chapter
2017-2018 Alessandra Mantovani, MD Pediatric Cerebrovascular Surgery & Interventions Fellow (inaugural) Supervision of endovascular neurosurgery clinical and research fellowship
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Years Name and degrees / Current position 2018-2019 Leo Arko, MD
Pediatric Cerebrovascular Surgery & Interventions Fellow Supervision of endovascular neurosurgery clinical and research fellowship
Visiting Clinical Fellows Years Name Jan 2009 – Mar 2010
Clemens Schirmer, MD Tufts Medical Center (Neurosurgery) While a neurosurgery resident at Tufts, Dr. Schirmer spent 3 months in elective rotation at Children’s Hospital, during which he scrubbed in for pediatric neurointerventional cases 1-2 times/week
Nov 2010 – Jun 2011
Daniel Oh, MD Massachusetts General Hospital (Neurointerventional Radiology) While a neurointerventional fellow at MGH, Dr. Oh has attended cases at Children’s Hospital approximately every other week, in an effort to broaden his exposure to the spectrum and management of pediatric neurovascular disease
Jan 2011 – Feb 2011
Michael Ellis, MD University of Toronto (Neurosurgery) Pediatric neurosurgery and neurointerventional radiology elective, wrote a textbook chapter and two clinical research manuscripts
May 2014 – Jun 2014
Donnie Bell, MD Massachusetts General Hospital (Neurointerventional Radiology) While a neurointerventional fellow at MGH, Dr. Bell attended cases at Children’s Hospital every week, in an effort to broaden his exposure to the spectrum and management of pediatric neurovascular disease
Sep 2017 – Dec 2017
Abdullah Alawad, MD King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia (Neurointerventional Radiology) After completing neurointerventional radiology fellowships at Johns Hopkins and Hopital Foch in Paris, Dr. Alawad spent 3 months full time at Children’s Hospital, in an effort to broaden his exposure to the spectrum and management of pediatric neurovascular disease, observing all neurointerventional procedures and many vascular anomalies IR procedures during that period.
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Years Name Sep 2017 – Dec 2017
Andrea Rosi, MD University of Florence Careggi Hospital, Florence, Italy (Neurointerventional Radiology) As the penultimate step towards completion of his neurointerventional radiology training at the Careggi Hosital of the University of Florence, Dr. Rosi was awarded a research fellowship by the Meyer Fonazione Pediatrico in Florence, to spend spent 3 months full time at Children’s Hospital, in an effort to broaden his exposure to the spectrum and management of pediatric neurovascular disease. In addition to observing all neurointerventional procedures during that time, Dr. Rosi initiated and brought close to completion a major project analyzing the clinical and radiographic characteristics of moyamoya in our Children’s cohort, as well as an analysis of currently used grading scales and risk factor assessment. This culminated in his thesis project, submitted to Careggi, and is expected to lead to several publications that will represent major contributions to the field of moyamoya.
Mentored MPH Candidate Years Name Jun 2017 – Jul 2018
Marlise Peruzzo dos Santos, MD MSc Harvard School of Public Health Dr. Santos is an Associate Professor of Radiology at The University of Ottawa Hospital, and a candidate for an MPH in epidemiology at HSPH. I am serving as her Harvard mentor for the Practicum portion of her MPH, supervising two clinical research projects on the long-term clinical outcome of patients with coiled brain aneurysms
Clinical Shadowing & Supervision - Premedical Years Name 6/2008-9/2008 Ashley Williams/ Undergraduate Fairfield University
Undergraduate Supervision of clinical research, leading to publication of a retrospective case series on the embolization of pediatric arteriovenous CNS lesions
5/2014-6/2014 Benjamin Cooper / Gann Academy High School Clinical shadowing and supervision of clinical research in the context of a 6-week internship, leading to publication of retrospective case series on prenatal dural sinus malformations
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Years Name 5/2015-6/2015 Oren Bazer & Leah Mekler / Gann Academy
High School Clinical shadowing and supervision of clinical research in the context of a 6-week internship
4/2015 Maha Shady, Ahmed Eltahir MIT Physician Shadow Program Supervision of pre-medical upperclass MIT undergraduates
5/2015 Cameron Waites, Emmanuel Carrodeguas, Zihao Yan, Ryan Din Boston Children’s Hostpital-Harvard Medical School Shadow Program Supervision of HMS students
Mentored Trainees and Faculty Years Name
2007-2015 Padma Sundaram, PhD / Instructor in Radiology, Harvard Medical School
2010-Present Mukund Balasubramanian, PhD / Instructor in Radiology, Harvard Medical School
Formal Teaching of Peers (e.g., CME and other continuing education courses) Years
Title Course Name
Number of Talks Location
2006-2008 Neurointerventional Treatment of Intracranial Aneurysms and AVMs BWH Radiology CME MR/CT Update
Three annual presentations Boston MA
2007 Neurointerventional Management of Extracranial Vascular Malformations BCH ICP Unit Staff
2013-2015 Syndromic Vascular Malformations of the Spine Harvard Neuroradiology CME Course
Single presentation Boston MA
Local Invited Presentations Year Title of Presentation / Type of Presentation
Department and Institution where presented 2006 Magnetic Resonance Encephalography: A Research Proposal
Surgical Planning Laboratory, Brigham and Women’s Hospital
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Year Title of Presentation / Type of Presentation Department and Institution where presented
2006 Magnetic Resonance Encephalography: Patient Recruitment and Collaboration Epilepsy Group Research Meeting, Boston Children’s Hospital
2008 Pediatric Arteriovenous Shunts Grand Rounds, Department of Neurosurgery, Brigham’s and Woman’s Hospital
2008 Endovascular Therapy for Pediatric Acute Ischemic Stroke Department of Radiology, Boston Children’s Hospital
2009 Neurointerventional Management of Extracranial Vascular Malformations and Pediatric CNS Arteriovenous Lesions Neurology/Neurosurgery Unit staff, Boston Children’s Hospital
2009 The use of Onyx for Embolization of Pediatric CNS Arteriovenous Lesions: Review of Cases ev3 Boston Area Neurointerventional Fellows’ Symposium
2010 Vein of Galen Malformations: Diagnosis, Natural History, and Treatment Advanced Fetal Care Center, Boston Children’s Hospital
2012 Encephalographic MRI: A New Paradigm Harvard School of Public Health Biostatistics Group Research Symposium
2012 Radiation Dose to Patients in Pediatric Neuro-IR: A Model for Self-Reckoning Grand Rounds, Department of Radiology, Boston Children’s Hospital
2013 A Neurointerventionalist’s Approach to CNS Lesions Medical-Surgical ICU Conference, Boston Children’s Hospital
2014 Pediatric Brain and Spine Vascular Lesions Medical-Surgical ICU Nursing Education Day, Boston Children’s Hospital
2016 Pediatric Stroke Department of Neuroradiology, Massachusetts General Hospital (3/1/16)
2016 Acute Stroke Cardiac Intensive Care Unit, Boston Children's Hospital (6/21/16)
2016 1) Pediatrics Lecture: Syndromic Vascular Malformations of the Spine; 2) Interactive Vascular Case Panel Member Symposium on Spine Imaging, Neuroradiology Post Graduate Course and Head and Neck Radiology, Department of Radiology, Massachusetts General Hospital (9/21/16)
2016 Vein of Galen Malformations: Prenatal and Postnatal Management Advanced Fetal Care Center, Boston Children’s Hospital
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Report of Regional, National and International Invited Teaching and Presentations Invited Presentations and Courses Regional Year Presentation or Course Title / Type of Presentation
Location 2003 Presentation, Diagnosis, and Management of Acute Stroke/ Cerebrovascular Accidents:
What the Pharmacist Needs to Know / Invited Podium Presentation Long Island University NY-Area Pharmacy CME
2004 Comparison of SNR and CNR between single-channel, multi-channel phase array coils at 1.5 T and a single-channel coil at 3.0 Tesla for clinical neuroimaging / Invited Podium Presentation [abstract] Eastern Society of Neuroradiology, Boston, MA
2008 Neurointerventional therapy for Stroke/ Hot Topics and Current issues in Imaging / Invited Podium Presentation New York Roentgen Society, New York, NY
2013 Arterial Ischemic Stroke in Children / Invited Podium Presentation New England Roentgen Ray Society, Boston, MA
National Year
Presentation or Course Title / Type of Presentation Location
1995 Time course and wavelength dependence of the intrinsic optical signal in visual cortex investigated with a modified Karhunen- Loeve procedure / Podium Presentation [abstract] Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida
1997 Color columns in macaque V1: Two novel color systems are revealed by intrinsic optical imaging / Podium Presentation [abstract] Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida
2005 Utility of CT angiography with virtual angioscopy versus doppler ultrasound in the examination of the stented carotid artery / Podium Presentation [abstract] American Society of Neuroradiology, Toronto, Canada
2008 The Use of onyx for embolization of extracranial head & neck vascular lesions / Invited Single Presentation Presentation to FDA Advisory Board, Washington, D.C.
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Year
Presentation or Course Title / Type of Presentation Location
2009 Pediatric central nervous system arteriovenous lesions/ Grand Rounds Lecture / Invited Single Presentation Carle Clinic – University of Illinois at Urbana-Champaign
2010 Advances in imaging of epilepsy and sleep / Invited Lecture American Society of Clinical Neurophysiology, San Diego, California
2010 PHACE syndrome research workshop: Standard of care in diagnostic workup and management / Invited Participant Children’s Hospital of Wisconsin, Milwaukee, Wisconsin
2012 Encephalographic MRI and pediatric epilepsy / Invited Lecture American Society of Pediatric Neuroradiology, New York, New York
2012 Encephalographic MRI: A new paradigm in functional neuroimaging / Invited Lecture American Society of Functional Neuroradiology, Orlando, Florida
2012 Pediatric Neuroangiography / Invited Lecture Society of Vascular and Interventional Neurology, Miami, Florida
2012 Radiation exposure during cerebral angiography and neuroembolization in children / Podium Presentation [abstract] Society for Neurointerventional Surgery, San Diego, California
2013 Arterial Ischemic Stroke in Children: A Neurointerventionalist’s Perspective / Invited Lecture Society for Pediatric Radiology, San Antonio, Texas
2013 Radiation exposure to patients during neurointerventional procedures in children: A warning / Podium Presentation [abstract] American Association of Neurological Surgeons, New Orleans, Louisiana
2013 Managing Pediatric Neurovascular Diseases / Invited Lecture Congress of Neurological Surgeons, San Francisco, California
2014 Pathogenesis of Dural Sinus Malformations as Demonstrated by Fetal Imaging: A Decision-Making Crucible for Parents and Clinicians / Invited Lecture SNIS 11th Annual Meeting, Colorado Springs, CO
2014 Pediatric CNS Vascular Malformations, Diagnosis and Treatment / Invited Lecture Society of Pediatric Radiology (SPR) Advances in Pediatric Neuroradiology, Miami, FL
2015 Skin Lesions & Pediatric Cerebrovascular Disease – A Neurointerventionalist’s Perspective / Invited Lecture Society for Pediatric Dermatology 41st Annual Meeting, Boston, MA
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Year
Presentation or Course Title / Type of Presentation Location
2015 The Neurointerventionalist & the Spine: Pediatric Spinal Vascular Lesions / Invited Lecture SNIS 12th Annual Meeting, San Francisco, CA
2015 Pediatric Aneurysms & Arteriopathy: A Neurointerventionalist’s Perspective / Invited Lecture RSNA Neuroradiology Refresher Course, Chicago, IL
2016 Where Should Interventions for Acute Ischemic Stroke in Children Take Place? / Invited Lecture International Stroke Conference, Los Angeles, CA
2016 Safety in Pediatric Neurointerventions: Vascular Access and Radiation Issues / Invited Lecture SNIS 13th Annual Meeting, Boston, MA
2017 Visiting Professorship: CNS Vascular Anomalies in Children (Grand Rounds / Case Conference / House Staff Lecture) Emory University Hospital, Atlanta, GA
2017 Flow Diverters in Children / Invited Lecture SNIS 14th Annual Meeting, Colorado Springs, CO
2017 Pediatric Neurointerventions / Invited Faculty SNIS/Joint Cerebrovascular Section Fellows Course, Colorado Springs, CO
2017 Pediatric Brain AVMs: Development, Natural History, & Treatment / Invited Lecture Society of Vascular and Interventional Neurology, Boston, MA
International Year Presentation or Course Title / Type of Presentation
Location 1996 Color & luminance processing in macaque VI: Spatial structure revealed by intrinsic
optical imaging/ Podium Presentation [abstract] Society for Neuroscience, Washington, DC
2009 Fractured Onyx cast and sheared microcatheter during preoperative embolization of infantile myofibromatosis in a 13-month old patient / Podium Presentation [abstract] World Federation of Interventional and Therapeutic Neuroradiology, Montreal, Canada
2010 The use of Onyx for embolization of extracranial head and neck vascular malformations and tumors / Podium Presentation [abstract] International Society for the Study of Vascular Anomalies, Brussels, Belgium
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Year Presentation or Course Title / Type of Presentation Location
2011 Angioarchitectural features associated with hemorrhagic presentation in pediatric cerebral arteriovenous malformations / Podium Presentation [abstract] World Federation of Interventional and Therapeutic Neuroradiology, Capetown, South Africa
2011 Safety of neuroangiography and embolization in children: Complication analysis in 379 consecutive cases / Podium Presentation [abstract] World Federation of Interventional and Therapeutic Neuroradiology, Capetown, South Africa
2011 Pial arteriovenous fistulae in pediatric patients: Associated syndromes and treatment / Podium Presentation [abstract] World Federation of Interventional and Therapeutic Neuroradiology, Capetown, South Africa
2011 Endovascular treatment of an MCA aneurysm developing after pial synangiosis for moyamoya disease / Podium Presentation [abstract] World Federation of Interventional and Therapeutic Neuroradiology, Capetown, South Africa
2013 Pediatric neurointerventions / Invited Speaker Great Ormond Street Hospital, London, UK
2013 Galenic fistulae / Invited Plenary Speaker World Federation of Interventional and Therapeutic Neuroradiology, Buenos Aires, Argentina
2015 Ethics in neurointerventions / Invited Speaker Anatomy-Biology-Clinical Correlations – Working Group in Interventional Neuroradiology, Val d’Isère, France
2015 Lower Vertebro-epidural fistulas: presentation and treatment / Podium Presentation [abstract] Anatomy-Biology-Clinical Correlations – Working Group in Interventional Neuroradiology, Val d’Isère, France
2015 Neurovascular Anatomy & Congenital Cerebrovascular Anomalies / Invited Faculty Course in Functional Neurovascular Anatomy – WFITN & European Society of Neuroradiology, Lisbon, Portugal
2015 Technical Aspects of Pediatric Neurointerventions – World Federation of Interventional and Therapeutic Neuroradiology, Gold Coast, Australia
2016 Brainstem Compression from Basilar Arteriovenous Fistula – A Radical Treatment Anatomy-Biology-Clinical Correlations – Working Group in Interventional Neuroradiology, Val d’Isère, France
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Year Presentation or Course Title / Type of Presentation Location
2017 Pediatric Interventions – An Interactive Potpourri & Acute Stroke in Children / Invited Speaker Toronto INR Symposium & 3rd Annual Karel Terbrugge Lectureship, Toronto, Canada
2017 Vein of Galen Malformations: What is at the Forefront? / Invited Faculty [abstract] Anatomy-Biology-Clinical Correlations – Working Group in Interventional Neuroradiology, Val d’Isère, France
2018 Vein of Galen Arteriovenous Malformations / Invited Faculty Anatomy-Biology-Clinical Correlations – Working Group in International Neuroradiology, Val d’Isère, France
2018 Pediatric Brain Aneurysms / Invited Faculty Campo Base Neurovascolare, University of Florence Careggi Hospital, Florence, Italy
Report of Clinical Activities and Innovations Current Licensure and Certification Year Type of License or Certification 1999 New York Medical License
2004 Certificate of the American Board of Psychiatry and Neurology in Neurology
2004 Certificate of the American Board of Radiology in Diagnostic Radiology
2005 Certificate of added Qualification in Neuroradiology, American Board of Radiology
2006 Massachusetts Medical License
2016 Certificate of added Qualification in Neuroradiology, American Board of Radiology, Recertification
2017 The Society of Neurological Surgeons Committee on Advanced Subspecialty Training (CAST): Certification in Neuroendovascular Surgery (newly developed certification)
Practice Activities Years Type of Activity Name of Practice Level of Activity 2003-2005 Diagnostic Neuroradiology
Moonlighting Practice Saint Vincent’s Catholic Medical Center, New York
1 day/week
2006-2009 Neurointerventional Radiology Hospital Practice
Boston Children’s Hospital & Brigham and Women’s Hospital
3-4 procedural days/week
Darren Benjamin Orbach, MD PhD HMS Curriculum Vitae
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Years Type of Activity Name of Practice Level of Activity 2006-2010 Neurointerventional
Radiology Hospital Practice Brigham and Women’s Hospital & Beth Israel Deaconess Medical Center
Call Coverage every 3rd weekend
2009-Present Neurointerventional Radiology Hospital Practice
Boston Children’s Hospital 3 elective procedural days/week, year-round urgent and call coverage
2009-Present Neurointerventional consultations and treatment of adults with head and neck vascular malformations
Brigham and Women’s Hospital
1-3 cases/year
Clinical Innovations • Working closely with colleagues from Neurosurgery and Neurology to build a nationally and
internationally recognized multidisciplinary group for the diagnosis and treatment of pediatric neurovascular disease, offering the full gamut of treatment for pediatric stroke and vascular malformations of the brain and spinal cord. Consultations are received and patients are treated from throughout North America, South America, Europe, and Asia. Seamlessly tight integration of all aspects of clinical care, follow-up, and outcomes research in this patient cohort are now a reality, with the formal establishment of the Cerebrovascular Surgery & Interventions Center at Children’s in late 2013, co-directed by Dr. Edward Smith of Neurosurgery and me.
• Pioneering the use of novel embolic agents and creative use of access devices developed for adults (e.g. Onyx, intermediate catheters, novel vascular occlusion devices), in children with intracranial and extracranial vascular anomalies. Close work in assessing treatment response is ongoing with the Vascular Anomalies Center and colleagues from the departments of Plastic Surgery, Otolaryngology, and Neurosurgery.
• Development of a program for intra-arterial chemotherapy for retinoblastoma, in coordination with colleagues in Oncology and Ophthalmology. In this context, we serve on the steering committee for the Children’s Oncology Group formal study of intra-arterial retinoblastoma.
• As Division Chief of Interventional Radiology, fostering the development of Interventional Radiology-based treatment approaches to solid tumors at Boston Children’s Hospital and the Dana Farber Institute, in coordination with colleagues in Oncology, General Surgery, and Head and Neck Surgery, and Orthopedics. Approaches range from participation in international, multicenter randomized prospective trials for primary therapy, to adapting techniques used by interventionalists in adults (e.g. RF ablation, cryotherapy), for children with recurrent or resistant tumors, to palliative IR-based treatment for pain and functional limitations.
• Overseeing the development and implementation of an electronic Interventional Radiology case protocol system, allowing for iterative input from attending physicians, nurse practitioners, technologists, and schedulers. The system replaced the paper-based protocolling that had been in place and resulted in a significant gain in efficiency and drop in error rate.
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• Overseeing the rollout of the first known Radiologists’ Assistant program nationwide, in Interventional Radiology in a pediatric setting. Our RA placed vascular access lines and enteric tubes and performs biopsies and drainages under the supervision of IR attending physicians. Her work dramatically increased our Division’s clinical efficiency, while she consistently earned praise from patients and families. Her complication rate and average procedural fluoroscopic dose were equal to or lower than the attending physicians’. Implementing this program required close coordination with the Hospital and Department administration, as well as with numerous intra-divisional caregivers. The program was stopped due to absence of a national billing infrastructure for RA work.
• Developing a novel fetal intervention for vein of Galen malformations, along with colleagues from Children’s and BWH in high-risk maternal-fetal medicine, pediatric radiology, pediatric anesthesia, and neonatal intensive care. Ultrasound-guided direct transabdominal needle access to the vein of Galen malformation via the fetus’ posterior fontanelle will be attempted on a compassionate care basis in three cases where, based on current treatment options, the fetus faces a poor prognosis. The technique is being developed using a fetal brain model custom-built by the Children’s simulation group. If successful in the three early cases, a formal IRB-approved clinical trial assessing the safety and efficacy of fetal treatment of vein of Galen malformations will be run.
Report of Education of Patients and Service to the Community Activities Year(s) Organization or Institution/ Role / Description
2002 Young Presidents Organization, Prague University / YPO University Invited Faculty / Neuroscience seminar for worldwide business leaders
2002 Young Presidents Organization, Big Sky, Montana / Invited Speaker / Neuroscience seminar for business leaders in Northwestern U.S.A.
2011 Medical Advisor to the CLOVES Syndrome Community Organization / Advisory role regarding brain and spine involvement by AVM in CLOVES patients
2015 Boston Children’s Hospital Moyamoya Day / Invited Speaker / Imaging and Moyamoya: Everything you Wanted to Know about Angiography & MRI
2015 Medical Advisor Board of the PHACE Syndrome Community / Advisory role regarding cerebrovascular manifestations of PHACES
2016 Boston Children’s Hospital Vein of Galen Malformation & Brain AVM Day / Invited Speaker / Vein of Galen Malformations & Brain AVMs: An overview of Clinical Presentation, Imaging Features, and Treatment
2017 Boston Children’s Hospital Moyamoya Day / Invited Speaker / Imaging and Moyamoya: Everything you Wanted to Know about Angiography & MRI
2018 Boston Children’s Hospital Vein of Galen Malformation & Brain AVM Day / Invited Speaker / Vein of Galen Malformations & Brain AVMs: An overview of Clinical Presentation, Imaging Features, and Treatment
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Year(s) Organization or Institution/ Role / Description 2018 PHACE Syndrome Community National Conference/ Invited Speaker / Cerebrovascular
Anomalies in PHACE, Angiograms, and the Role of Neurointerventional Radiology & Neurosurgery
Recognition Year(s) Name of Award / Recognition Organization Conferring Recognition
2010 Peer selection for expert consultation (neurointerventional radiology)
Best Doctors, Inc.
2011-2016 America’s Top Doctors (designated as among the top 10% of neuroradiologists regionally)
Castle Connolly, Inc.
2012-2014 US News Top Doctors (designated by peer recommendation as among the top 1% of neuroradiologists in the United States)
US News & World Report
2012-2018 Boston’s Top Doctors Boston Magazine
Report of Scholarship
Peer Reviewed Publications Research Investigations 1. Sirovich L, Everson R, Knight BW, Kaplan E, O’Brien E, Orbach D. Modeling the functional
organization of the visual cortex. Physica D 1996;96:355-66.
2. Orbach D, Romanelli P, Devinsky O, Doyle W. Late seizure recurrence after multiple subpial transections. Epilepsia. 2001 Oct; 42 (10):1316-1319. PMID: 11737166.
3. Spencer SS, Schramm J, Wyler A, O'Connor M, Orbach D, Krauss G, Sperling M, Devinsky O, Elger C, Lesser R, Mulligan L, Westerveld M. Multiple subpial transection for intractable partial epilepsy: an international meta-analysis. Epilepsia. 2002 Feb;43(2):141-145. PMID: 11903459
4. Orbach D, Ritaccio A, Devinsky O. Psychogenic, nonepileptic seizures associated with video-EEG-verified sleep. Epilepsia. 2003 Jan;44(1):64-68. PMID: 12581231
5. Devinsky O, Romanelli P, Orbach D, Pacia S, Doyle W. Surgical treatment of multifocal epilepsy involving eloquent cortex. Epilepsia. 2003 May;44(5):718-723. PMID: 12752473
6. Lui YW, Nusbaum AO, Barr WB, Johnson G, Babb JS, Orbach D, Kim A, Laliotis G, Devinsky O. Correlation of apparent diffusion coefficient with neuropsychological testing in temporal lobe epilepsy. AJNR Am J Neuroradiol. 2005 Aug;26(7):1832-1839. PMID: 16091538
8. Orbach DB, Wu C, Law M, Babb JS, Lee R, Padua A, Knopp EA. Comparing real-world advantages
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for the clinical neuroradiologist between a high field (3 T), a phased array (1.5 T) vs. a single-channel 1.5-T MR system. J Magn Reson Imaging. 2006 Jul;24(1):16-24. PMID: 16767701
9. Orbach DB, Nelson PK. Is endovascular embolization reliable as a long-term cure for ruptured cerebral aneurysms? Nature Clinical Practice Neurology. 2006;2:420-421.
10. Viswanathan V*, Smith ER, Mulliken JB, Fishman SJ, Kozakewich HP, Burrows PE, Orbach DB. Infantile hemangiomas involving the neuraxis: clinical and imaging findings. AJNR Am J Neuroradiol. 2009 May;30(5):1005-1013. PMID: 19213817
11. Thiex R*, Williams A, Smith E, Scott RM, Orbach DB. The use of Onyx for embolization of central nervous system arteriovenous lesions in pediatric patients. AJNR Am J Neuroradiol. 2010 Jan;31(1):112-120. PMID: 19749215
12. Thiex R*, Mulliken JB, Revencu N, Boon LM, Burrows PE, Cordisco M, Dwight Y, Smith ER, Vikkula M, Orbach DB. A novel association between RASA1 mutations and spinal arteriovenous anomalies. AJNR Am J Neuroradiol. 2010 Apr;31(4):775-779. PMID: 20007727
13. Alomari AI, Orbach DB, Mulliken JB, Bisdorff A, Fishman SJ, Norbash A, Alokaili R, Lord DJ, Burrows PE. Klippel-Trenaunay syndrome and spinal arteriovenous malformations: an erroneous association. AJNR Am J Neuroradiol. 2010 Oct;31(9):1608-1612. PMID: 20651014
14. Sundaram P*, Wells WM, Mulkern RV, Bubrick EJ, Bromfield EB, Munch M, Orbach DB. Fast human brain magnetic resonance responses associated with epileptiform spikes. Magn Reson Med. 2010 Dec;64(6):1728-1738. PMID: 20806355
15. Thiex R*, Wu I, Mulliken JB, Greene AK, Rahbar R, Orbach DB. Safety and clinical efficacy of Onyx for embolization of extracranial head and neck vascular anomalies. AJNR Am J Neuroradiol. 2011 Jun-Jul; 32(6):1082-1086. PMID: 21454409
16. Morris SA*, Orbach DB, Geva T, Singh MN, Gauvreau K, Lacro RV. Increased vertebral artery tortuosity index is associated with adverse outcomes in children and young adults with connective tissue disorders. Circulation. 2011 Jul 26; 124(4):388-396. PMID: 21730308
17. Alomari AI, Chaudry G, Rodesch G, Burrows PE, Mulliken JB, Smith ER, Fishman SJ, Orbach DB. Complex spinal-paraspinal fast-flow lesions in CLOVES syndrome: analysis of clinical and imaging findings in 6 patients. AJNR Am J Neuroradiol. 2011 Nov-Dec; 32(10):1812-1817. PMID: 21310861
18. Sundaram P*, Mulkern RV, Wells WM, Triantafyllou C, Loddenkemper T, Bubrick EJ, Orbach DB. An empirical investigation of motion effects in eMRI of interictal epileptiform spikes. Magn Reson Imaging. 2011 Dec; 29(10):1401-1409. PMID: 21550748
19. Kim SW, Kavanagh K, Orbach DB, Alomari AI, Mulliken JB, Rahbar R. Long-term outcome of radiofrequency ablation for intraoral microcystic lymphatic malformation. Arch Otolaryngol Head Neck Surg. 2011 Dec; 137(12):1247-1250. PMID: 22183906
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21. Walcott BP*, Smith ER, Scott RM, Orbach DB. Dural arteriovenous fistulae in pediatric patients: associated conditions and treatment outcomes. Journal of Neurointerventional Surgery. 2013 Jan 1; 5(1):6-9. PMID: 22213835
22. Walcott BP*, Smith ER, Scott RM, Orbach DB. Pial arteriovenous fistulae in pediatric patients: associated syndromes and treatment outcome. Journal of Neurointerventional Surgery. 2013 Jan 1; 5(1):10-14. PMID: 22213836
23. Mulkern RV, Balasubramanian M, Orbach DB, Mitsouras D, Haker SJ. Incorporating reversible and irreversible transverse relaxation effects into Steady State Free Precession (SSFP) signal intensity expressions for fMRI considerations. Magnetic Resonance Imaging. 2013 Apr; 31(3):346-352. PMID: 23337079
24. Silvera VM, Gordon LB, Orbach DB, Campbell SE, Machan JT, Ullrich NJ. Imaging characteristics of cerebrovascular arteriopathy and stroke in Hutchinson-Gilford progeria syndrome. AJNR Am J Neuroradiol. 2013 May; 34(5):1091-1097. PMID: 23179651
25. Ellis MJ*, Armstrong D, Vachhrajani S, Kulkarni AV, Dirks PB, Drake JM, Smith ER, Scott RM, Orbach DB. Angioarchitectural features associated with hemorrhagic presentation in pediatric cerebral arteriovenous malformations. Journal of Neurointerventional Surgery. 2013 May; 5(3):191-195. PMID: 22416111
26. Orbach DB, Stamoulis C, Strauss KJ, Manchester J, Smith ER, Scott RM, Lin N. Neurointerventions in children: Radiation exposure and its import. AJNR Am J Neuroradiol. 2014 April. PMID: 24157736
27. Gross BA, Orbach DB. Addressing challenges in 4 F and 5 F arterial access for neurointerventional procedures in infants and young children. Journal of neurointerventional surgery. 2014 May; 6(4):308-313. PMID: 23468537
28. Chandra RV, Leslie-Mazwi TM, Orbach DB, Kaban LB, Rabinov JD. Transarterial embolization of mandibular arteriovenous malformations using ONYX. Journal of oral and maxillofacial surgery. 2014 Aug; 72(8):1504-1510. PMID: 24704035
29. Balasubramanian M*, Mulkern RV, Wells WM, Sundaram P, Orbach DB. Magnetic resonance imaging of ionic currents in solution: the effect of magnetohydrodynamic flow. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 2015 Oct; 74(4):1145-1155. PMID: 25273917.
30. Gross BA*, Storey A, Orbach DB, Scott RM, Smith ER. Microsurgical treatment of arteriovenous malformations in pediatric patients: the Boston Children's Hospital experience. J Neurosurg Pediatr. 2015 Jan; 15(1):71-77. PMID: 25360855
31. Gross BA*, Smith ER, Scott RM, Orbach DB. Intracranial aneurysms in the youngest patients: characteristics and treatment challenges. Pediatric neurosurgery. 2015 Feb; 50(1):18-25. PMID: 25721683
32. Lin N*, Smith ER, Scott RM, Orbach DB. Safety of neuroangiography and embolization in children: complication analysis of 697 consecutive procedures in 394 patients. J Neurosurg Pediatr. 2015 Jun 26; 1-7. PMID: 26114994
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33. Weinstock P, Prabhu SP, Flynn K, Orbach DB, Smith E. Optimizing cerebrovascular surgical and endovascular procedures in children via personalized 3D printing. J Neurosurg Pediatr. 2015 Jul 31; 1-6. PMID: 26230460
34. Gross BA, Du R, Orbach DB, Scott RM, Smith E. The natural history of cerebral cavernous malformations in children. J Neurosurg Pediatr. 2015 Oct 16; 1-6. PMID: 26474098
35. Sundaram P, Nummenmaa A, Wells W, Orbach D, Orringer D, Mulkern R, Okada Y. Direct neural current imaging in an intact cerebellum with magnetic resonance imaging. Neuroimage. 2016 May 15; 132477-490. PMID: 26899788.
36. Ashour R*, Orbach DB. Lower vertebral-epidural spinal arteriovenous fistulas: a unique subtype of vertebrovertebral arteriovenous fistula, treatable with coil and Penumbra Occlusion Device embolization. J Neurointerv Surg. 2016 Jun; 8(6):643-647. PMID: 25964377.
37. See AP, Kochis MA, Khandelwal P, Orbach DB. Considerations in applying a new stent retriever in pediatric endovascular cerebral thrombectomy for acute ischemic stroke. Pediatric Neurosurgery. 2016 51(5):263-268. PMID: 27216798.
38. Garzon MC, Epstein LG, Heyer GL, Frommelt PC, Orbach DB, Baylis AL, Blei F, Burrows PE, Chamlin SL, Chun RH, Hess CP, Joachim S, Johnson K, Kim W, Liang MG, Maheshwari M, McCoy GN, Metry DW, Monrad PA, Pope E, Powell J, Shwayder TA, Seigel DH, Tollefson MM, Vadievelu S, Lew SM, Frieden IJ, Drolet BA. PHACE Syndrome: Consensus-derived diagnosis and care recommendations. J Pediatrics. 2016 Sep 19. S0022-3467(16)30656-4. PMID: 27659028
39. Balasubramanian M, Wells WM, Ives JR, Britz P, Mulkern RV, Orbach DB. RF Heating of Gold Cup and Conductive Plastic Electrodes during Simultaneous EEG and MRI. Neurodiagn J. 2017 Apr 25; 57 (1):69-83. PMID: 28436813.
40. Wolter NE, Adil E, Irace AL, Werger A, Perez-Atayde AR, Weldon C, Orbach DB, Rodriguez-Galindo C, Rahbar R. Malignant glomus tumors of the head and neck in children and adults: Evaluation and management. Laryngoscope. 2017 Dec; 127 (12):2873-2882. PMID: 28294349.
41. Yang E, Storey A, Olson HE, Soul J, Estroff JA, Trenor CC, Cooper BK, Smith ER, Orbach DB. Imaging features and prognostic factors in fetal and postnatal torcular dural sinus malformations, part I: review of experience at Boston Children's Hospital. J Neurointerv Surg. 2018 May; 10 (5):467-470. PMID: 28965107.
42. Yang E, Storey A, Olson HE, Soul J, Estroff JA, Trenor CC, Cooper BK, Smith ER, Orbach DB. Imaging features and prognostic factors in fetal and postnatal torcular dural sinus malformations, part II: synthesis of the literature and patient management. J Neurointerv Surg. 2018 May; 10 (5):471-475. PMID: 28965104.
43. Duran D, Karschnia P, Gaillard JR, Karimy JK, Youngblood MW, DiLuna ML, Matouk CC, Aagaard-Kienitz B, Smith ER, Orbach DB, Rodesch G, Berenstein A, Gunel M, Kahle KT. Human genetics and molecular mechanisms of vein of Galen malformation. J Neurosurg Pediatr. 2018 Apr; 21 (4):367-374. PMID: 29350590.
44. Riordan CP, Orbach DB, Smith ER, Scott RM. Acute fatal hemorrhage from previously undiagnosed cerebral arteriovenous malformations in children: a single-center experience. J Neurosurg Pediatr. 2018 Jun 1:1-7. PMID: 29856294.
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45. Duran D, Zeng X, Jin SC, Choi J, Nelson-Williams C, Yatsula B, Gaillard J, Furey CG, Lu Q, Timberlake AT, Dong W, Sorscher MA, Loring E, Klein J, Allocco A, Hunt A, Conine S, Karimy JK, Youngblood MW, Zhang J, DiLuna ML, Matouk CC, Mane S, Tikhonova IR, Castaldi C, Lopez-Giraldez F, Knight J, Haider S, Soban M, Alper SL, Komiyama M, Ducruet AF, Zabramski JM, Dardik A, Walcott BP, Stapleton CJ, Aagaard-Kienitz B, Rodesch G, Jackson E, Smith ER, Orbach DB, Berenstein A, Bilguvar K, Vikkula M, Gunel M, Lifton RP, Kahle KT. Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation. Neuron. 2018 Dec 13. PMID: 30578106.
46. Jernigan S, Storey A, Hammer C, Riordan C, Orbach DB, Scott RM, Smith ER. Moyamoya syndrome and PHACE syndrome; clinical and radiographic characterization of the intracranial arteriopathy and response to surgical revascularization. J Neurosurg Pediatr. Published online February 1, 2019 - https://thejns.org/view/journals/j-neurosurg-pediatr/aop/article-10.3171-2018.10.PEDS18582.xml.
Other Peer-Reviewed Publications 1. Orbach D, Hiesiger E. Shoulder pain relieved by root canal. Neurology. 2001 Nov 13;57(9):1712-
1713. PMID: 11706119
2. Chatterjee A, Orbach D. Isolated foot weakness caused by a parasagittal metastatic parotid adenocarcinoma. Neurol India. 2004 Jun;52(2):286-287. PMID: 15269511
3. Wang H*, Orbach DB. Traumatic dissecting aneurysm at the vertebrobasilar junction in a 3-month-old infant: evaluation and treatment strategies. Case report. J Neurosurg Pediatr. 2008 May;1(5):415-419. PMID: 18447682
4. Wang H*, Oh AK, Orbach DB. Arteriovenous shunting as a new feature of PHACES. Case report. J Neurosurg Pediatr. 2009 Jan;3(1):53-56. PMID: 19119905
5. Puri AS*, Thiex R, Zarzour H, Rahbar R, Orbach DB. Trigeminocardiac reflex in a child during pre-Onyx DMSO injection for juvenile nasopharyngeal angiofibroma embolization. A case report. Interv Neuroradiol. 2011 Mar;17(1):13-16. PMID: 21561553
6. Puri AS*, Rahbar R, Dearden J, Graham RJ, Lillehei C, Orbach DB. Stretched and sheared microcatheter retained after onyx embolization of infantile myofibromatosis. Interv Neuroradiol. 2011 Jun;17(2):261-266. PMID: 21696669
7. Ellis MJ*, Amlie-Lefond C, Orbach DB. Endovascular therapy in children with acute ischemic stroke: review and recommendations. Neurology. 2012 Sep 25; 79(13 Suppl 1):S158-164. PMID: 23008391
8. Gross BA*, Akgoz A, Orbach DB. Dural arteriovenous shunts in children. Journal of Pediatric Neuroradiology. 2013 Oct 2(3):263-268.
9. Akgoz A*, Gross BA, Lehman LL, Rivkin MJ, Orbach DB. Interventional management of acute ıschemic stroke in children. Journal of Pediatric Neuroradiology. 2013 Oct 2(3):269-275.
10. Yonekawa Y, Orbach DB, Trief D, Shah AS, Vanderveen DK. Intra-arterial Chemotherapy for Group C Retinoblastoma With Adjacent High-flow Infantile Hemangioma. Ophthalmic Surgery, Lasers & Imaging Retina. 2013 Sep 1; 44(5):490-492. PMID: 24044714
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11. Burch EA*, Orbach DB. Pediatric central nervous system vascular malformations. Pediatr Radiol. 2015 Sep; 45 Suppl 3:S463-472. PMID: 26346152.
12. Satti S, Chen J, Sivapatham T, Jayaraman M, Orbach DB. Mechanical thrombectomy for pediatric acute ischemic stroke: review of the literature. Journal of Neurointerventional Surgery. 2016 Jul 22. PMID: 27448827
13. See AP*, Kochis MA, Orbach DB. Segmental upper mid-basilar artery sacrifice in a child using a Micro Vascular Plug device for treatment of a basilar arteriovenous fistula compressing the brainstem. BMJ case reports. 2017 Mar 09; 2017. PMID: 28280085.
14. See AP*, Kochis MA, Orbach DB. Segmental upper mid-basilar artery sacrifice in a child using a Micro Vascular Plug device for treatment of a basilar arteriovenous fistula compressing the brainstem. J Neurointerv Surg. 2017 Mar 16. PMID: 28302864.
15. Penn DL*, Lanpher AB, Klein JM, Kozakewich HPW, Kahle KT, Smith ER, Orbach DB. Multimodal treatment approach in a patient with multiple intracranial myxomatous aneurysms. J Neurosurg Pediatr. 2018 Mar; 21 (3):315-321. PMID: 29303459.
16. Fehnel KP*, Klein J, Warf BC, Smith ER, Orbach DB. Reversible intracranial hypertension following treatment of an extracranial vascular malformation: case report. J Neurosurg Pediatr. Published online January 4, 2019 - https://thejns.org/view/journals/j-neurosurg-pediatr/aop/article-10.3171-2018.10.PEDS18235.xml.
17. Pokmeng See A*, Fehnel K, Orbach DB, Smith ER. Microsurgical ligation of residual fistulous arteriovenous shunt from a radicular artery to a thoracic arteriovenous malformation. Operative Neurosurgery. 2019; In press.
Non-peer reviewed scholarship in print or other media: Reviews 1. Orbach D, Hiesiger E. Chronic nonmalignant pain and the use of opioid analgesia (Analgesia
opioidowa w bólu przewlekłym pochodzenia nienowotworowego). Bol 2001;2:13-24. [Bol is a Polish journal of neurology.]
2. Choi D*, Alomari AI, Chaudry G, Orbach DB. Neurointerventional management of low-flow vascular malformations of the head and neck. Neuroimaging Clin N Am. 2009 May;19(2):199-218. PMID: 19442906
3. Wu IC*, Orbach DB. Neurointerventional management of high-flow vascular malformations of the head and neck. Neuroimaging Clin N Am. 2009 May;19(2):219-240, Table of Contents. PMID: 19442907
5. Monroy JE, Orbach DB, VanderVeen D. Complications of intra-arterial chemotherapy for retinoblastoma. Seminars in ophthalmology. 2014 Sep-Nov; 29(5-6):429-433. PMID: 25325870
6. Rodriguez-Galindo C, Orbach DB, VanderVeen D. Retinoblastoma. Pediatric clinics of North
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America. 2015 Feb; 62(1):201-223. PMID: 25435120
7. Ashour R*, Orbach DB. Interventional neuroradiology in children: diagnostics and therapeutics. Curr Opin Pediatr. 2015 Dec; 27(6):700-705. PMID: 26382708.
Chapters 1. Orbach D, Alastra AJG, Bose A, Nelson PK. Neurointerventional management of intracranial
2. Orbach DB, Bescske T, Nelson PK. Endovascular treatment of intracranial aneurysms. In: Hurst R, Rosenwasser R, eds. Interventional Neuroradiology. New York, NY: CRC Press; 2007; Ch 13:239-262.
3. Thiex R*, Puri A, Orbach DB. Neurointerventional radiology. In: Law M, Som PM, Naidich TP, eds. Problem Solving in Radiology: Neuroradiology. Philadelphia, PA: Elsevier Saunders, 2011; Ch 6:276-298.
4. Ellis MJ*, Smith ER, Orbach DB. The hybrid neurovascular operating room. In: Jolesz FA, editor. Intraoperative Imaging and Image-guided Therapy. New York, NY: Springer, 2013; Ch 21:301-310.
5. Shaikh R*, Orbach DB, Padua H. Interventional radiology in the management of pediatric head & neck lesions. In: Rahbar R, Meara J, Rodriguez-Galindo C, Smith ER, eds. Pediatric head and neck tumors: A-Z guide to presentation and multimodality management. New York, NY: Springer, 2014; Ch 5:39-48.
6. Rodriguez-Galindo C, Orbach DB, Vanderveen D. Retinoblastoma. In: Rahbar R, Rodriguez-Galindo C, Meara J, Smith ER, Perez-Atayde AR, eds. Pediatric Head and Neck Tumors: A-Z guide to presentation and multimodality management. New York: Springer, 2014; Ch 37:295-304.
8. Pandey SK*, Orbach DB. Pediatric Vascular Malformations. In: Saba L, Raz E, eds. Neurovascular Imaging: From Basics to Advanced Concepts. New York, NY: Springer New York, NY, 2016 Jan 22:983-1007.
9. See AP*, Orbach DB. Vein of Galen Arteriovenous Malformations. In: Caplan LR, Biller J, Leary M, Lo E, Thomas A, Yenari M, Zhang J, eds. Vein of Galen Arteriovenous Malformations. 2nd ed. San Diego, CA: Academic Press, 2017 Mar 6; Ch 97:482-486.
Letters to the Editor 1. Orbach D, Levine D. Outcomes of ancrod in acute ischemic stroke. JAMA. 2000 Oct
2. Orbach DB, Mulliken JB. Re: Spinal epidural hemangiomas: various types of MR imaging features with histopathologic correlation. AJNR Am J Neuroradiol. 2008 May;29(5):e31; author reply e32. PMID: 18388207
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3. Alomari AI, Orbach DB, Mulliken JB, Fishman SJ, Norbash A, Bisdorff A, Alokaili R, Lord DJ, Burrows PE. Reply: re. Klippel-Trenaunay syndrome and spinal arteriovenous malformations: An erroneous association? AJNR Am J Neuroradiol. 2011;32:e78-e79
4. Orbach DB, Vanderveen DK, Shah AS, Rodriguez-Galindo C. Blue toe syndrome: a complication of intra-arterial technique, not intra-arterial chemotherapy for retinoblastoma. JAMA ophthalmology. 2014 May; 132(5):654. PMID: 24810697
5. Orbach DB, Smith ER. Re: The influence of angioarchitecture on management of pediatric intracranial arteriovenous malformations. J Neurointerv Surg. (Epub 2013 Jun 29) 2016 Jun; 8(e1):e11-12. PMID: 23810958.
Doctoral Thesis 1. Orbach DB. The Functional Architecture of Color Representation in Area V1 of the Macaque
Cerebral Cortex: An Optical Imaging Study. New York (NY): Rockefeller University; 1997.
Professional Educational Materials or Reports, in Print or Other Media Podcasts 1. SNIS September 2013 Podcast – The influence of angioarchitecture on management of pediatric
intracranial arteriovenous malformations
2. AJNR July 2015 Podcast – Biographical interview: Training to be a pediatric neurointerventionalist
Abstracts, Poster Presentations, and Exhibits at Professional Meetings (last 3 years) 1. Crall CS*, Carlberg VM, Reeve JL, Orbach DB, Hawryluk EB, Liang MG. A 9-month old girl with red
birthmarks and an enlarged head. New England Dermatological Society; 31 Jan 2015; Boston, MA
2. Storey A, Orbach DB, Scott RM, Smith ER. Development of moyamoya arteriopathy following treatment of intracranial tumors: Clinical and radiographic characterization. International Stroke Conference; 2015 Feb 11-13; Nashville, TN
3. Storey A, Jernighan S, Smith ER, Scott RM, Orbach DB. Unique characteristics of moyamoya arteriopathy in children with PHACE. International Stroke Conference; 2015 Feb 11-13; Nashville, TN
4. Orbach DB, Storey A, Yang E. Fetal torcular dural sinus malformations: Imaging features, natural history, prognosis, & tretment. World Federation of Interventional Neuroradiology; 2015 November 9-13; Gold Coast, Australia
5. Lanpher AB, Klein J, Orbach DB, Smith ER, Ravindra V. Rapid de novo nidal aneurysm development in a child with an AVM. New England Neurosurgical Society; 2017 June 22-24; Chatham, MA
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6. Penn DL*, Lanpher AB, Klein J, Smith ER, Orbach DB, Kahle KT. Multi-modal treatment approach in a patient with multiple intracranial myxomatous aneurysms. New England Neurosurgical Society; 2017 June 22-24; Chatham, MA
7. Penn DL*, Pricola-Fehnel K, Moses-Gardner A, Orbach DB, Smith ER. Initial discovery and validation of urinary biomarkers specific to intracranial AVM using a transgenic mouse model correlated with a clinical series of pediatric patients. New England Neurosurgical Society; 2017 June 22-24; Chatham, MA
8. See AP*, Pricola-Fehnel K, Orbach DB, Smith ER. Relationship between case volume and outcomes during elective management of cerebrovascular malformations based on a national administrative database. World Fed Neurosurgery; 2018 August 15-19; Kuala Lumpur, Malaysia
9. See AP*, Pricola-Fehnel K, Orbach DB, Smith ER. Case volume and outcomes of intracranial hemangiomas based on a national administrative database. World Fed Neurosurgery; 2018 August 15-19; Kuala Lumpur, Malaysia
10. Riordan C*, Orbach DB, Smith ER, Scott RM. Acute fatal hemorrhage from previously undiagnosed cerebral arteriovenous malformations in children: a single-center experience. New England Neurosurgical Society; 2018 June 28-30; Chatham, MA
11. Alomari AI, Alomari MH, Kerr C, Chaudry G, Orbach D. Postprocedural Alopecia. Society for Pediatric Interventional Radiology 2018 Meeting (SPIR 2018), Maui, HI. 2019 October 23-27.
12. Arko L*, Riordan C, Klein J, Orbach DB, Smith ER. Outcomes for surgical and observed pediatric brainstem cavernoma patients. Neurosurgical Joint Section Cerebrovascular Meeting; 2019 February 4-5; Honolulu, HI.
13. Arko L*, Riordan C, Klein J, Orbach DB, Smith ER. Moyamoya disease and syndrome among pediatric stroke patients in the United States. Neurosurgical Joint Section Cerebrovascular Meeting; 2019 February 4-5; Honolulu, HI.
