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__________________________
Date of Preparation 182017
Signature
Meera B Chitlur Clinician Educator
Office Address Childrens Hospital of Michigan Division of HematologyOncology 3901 Beaubien Blvd Detroit MI 48201
Office Telephone 313-745-5515 Office Fax Number 313-745-5237 E-mail Address mchitlurmedwayneedu
DATES EDUCATION Apr 1983- Mar 1986 MES College (Science and Mathematics)
Bangalore India Kempegowda Institute of Medical Sciences MBBS
Aug 1986- Apr 1992 Bangalore India
POSTGRADUATE TRAINING Pediatric Residency
Jul 1994- Jul 1997 Henry Ford Hospital Detroit MI
Pediatric HematologyOncology Fellowship Jan 2001-Mar 2005 Childrens Hospital of Michigan
Detroit MI
FACULTY APPOINTMENTS rofessor of Pediatrics (Clinician-Educator Track) ayne State University School of Medicine
June 2016 to Present PW
Aug 2011-June 2016 Associate Professor Of Pediatrics (Clinician-Educator Track) Wayne State University School of Medicine
Assistant Professor of Pediatrics (Clinician-Educator track) Sept 2005-Aug 2011 Wayne State University School of Medicine
HOSPITAL OR OTHER PROFESSIONAL APPOINTMENTS Staff Physician Division of HematologyOncology Aug 2005- Present University Pediatricians PC
Research Assistant in Coagulation Division of HematologyOncology Mar 2005-Aug 2005 Childrenrsquos Hospital of MichiganWSU
Aug 1997- Dec 2000 Staff Physician Department of Pediatrics Mount Clemens General Hospital Mt Clemens MI 48043
Willow Pediatrics (private practice) Aug 1997- Dec 2000 35111 Dodge Park Sterling Heights MI 48312
2 MAJOR PROFESSIONAL SOCIETIES American Society of Hematology Hemophilia and Thrombosis Research Society International Society of Thrombosis and Hemostasis MEDICAL LICENSURE State of Michigan MedicalPharmacy License 4301 063540
BOARD CERTIFICATION Pediatric hematologyoncology
HONORSAWARDS Resident Teaching award (Associate Professor)
Selected by peers for inclusion in Hour Detroit magazines list of Top Docs
Elected to the Board of Directors of the Hemophilia and Thrombosis Research Society (HTRS)
Nominated for the 2015 ldquoAmericarsquos Best Physiciansrdquo directory-nominated by physicians recognizes top professionals with superior credentials experience exceptional patient care and commitment to excellence
Biography selected for Marquis Whos Who In Science and Engineering
Elected to membership on the National Hemophilia Foundations Medical and Scientific Advisory Council
Barnhart-Lusher Hemostasis Research Endowed Chair
College Teaching Award in the WSU School of Medicine
Recognized by peer review survey for inclusion in ldquoDetroit Super Doctorsrdquo featuring only 5 of physicians in the Detroit area by the Detroit News and Detroit Free Press websites
Recognized by patientsparents as ldquoMetro Parent Mom-Approved Docrdquo
Recognized as a 2011 ldquoPatientsrsquo Choicerdquo Physician of the nations 720000 active physicians only 5 were accorded this honor by their patients
Biography inclusion in the 66th Edition of Whorsquos Who in America
Certificate of Recognition for support amp mentorship of pediatric resident research
Recognized by peer review survey for inclusion in ldquoBest Docrsquos In Americardquo database
Wolf Zuelzer Award for best research during fellowship 3rd Place
Jan 2019
Dec 2019
2016
2016
2015- Present
2015
2015-2017
2014- Present
2013- Present
2012
2011-2014
2011
2011
2012-2015
2008
2007-2016
2004
3 SERVICE Affiliate medical organizations Member of the Clinical Competence Committee of the Pediatric HematologyOncology Fellowship Program Review and assessment of fellow clinical performance and provide recommendations to the fellowship program July 2014- Present director Director of Childrenrsquos Hospital Special Coagulation Laboratory Provides administrative oversight Responsible for maintaining Quality Control College of American Pathologists and CLIA certification Involved in new test Jul 2013-Present development and provides formal reports of platelet aggregation studies and thromboelastography reports for all patients Conduct weekly meeting of coagulation lab staff fellows and Staff physicians
Director Hemophilia Treatment Center and Hemostasis program Childrens Hospital of Michigan Provides administrative oversight Responsible for Sept 2011- Present protocol development and review of management Involved in the development of policies and procedures for patient care process improvement and patient satisfaction Responsible for administration of the PHS program including financial oversight and management Member of the Ambulatory Operations leadership council Involved with optimization of the clinic flow and quality improvement projects associated with day to day outpatient clinic operations and scheduling Regularly 2012-2014 attends bi-monthly meetings with pediatric administration to provide departmental input and also ensures implementation of policies approved at meetings Member of the In-patient distribution working group Pediatric Hematologyoncology representative at the working group addressing 2012-2014 patient distribution on in-patient units Involved with development of policies and procedures pertaining to better utilization of resident teams and physicians
SERVICE Professional August 2016- Present Invited member of the International Society if Thrombosis and Hemostasis(ISTH) Education Committee Invited member of the HTRS Publications committee August 2016- Present Invited Member of the Blood Products Advisory Committee (BPAC) of the FDA 2015-Present ModeratorChair of Scientific Session on Treatment of Acquired Hemostatic June 2015 Disorders at the International Society Of Thrombosis and Hemostasis (ISTH) Society Annual Meeting June 2015 Member of the Board of Directors for the Hemophilia and Thrombosis Apr 2015-Present Research Society (HTRS) Elected to the Board of Directors of the national research group for having developed nationally recognized expertise in hemostasis Member of the Medical and Scientific Advisory Committee (MASAC) of the 2014- Present National Hemophilia Foundation Invited member Nationally recognized for the development of national guidelines and recommendations for the management of patients with bleeding disorders
4 SERVICE Professional
Board member of the Intercontinental Cooperative ITP Study Group (ICIS) Manuscript writing and data collection by the International collaborative group
Member of The Women amp Girls with Blood Disorders (WGBD) Learning Action Network (LAN) for healthcare professionals Invited member Instrumental in the development of National Collaborative Research projects in Women and Girls with Bleeding disorders International Society of Thrombosis and Hemostasis ndash Co-chair of the FVIIIFIX subcommittee Working Party on Standardization of 2012-2014 Thromboelastography Developed the international recommendations for Standardization of Thromboelastography Chairman of the International TEG-ROTEM Working Group Instrumental in 2006-Present developing standardization and provided international guidance to methodology and validation Member of the Global Emerging HEmophilia Panel (GEHEP) Project leader and co-investigator for multiple projects with an International group of Researchers who actively conduct Research in Hemophilia and hemostasis
SERVICE Community
Presentation for lay audiences
Glanzmann Thrombasthenia 101 Invited by Comprehensive Health Education Services LLC a Not-for-profit company involved with providing health education to familiespatients to help patients and families of patients with Glanzmann Thrombasthenia obtain knowledge about the diagnosis
Von Willebrand Disease- Diagnosis and Treatment HFM Springfest
Von Willebrand Disease Treatment options- Midwest Regional VWD Conference
Treatment Options for Joint Disease in Hemophilia Presented at Hemophilia Foundation of Michigan-Springfest
Hemarthrosis in Hemophilia- Importance of prophylaxis in prevention of hemophilic arthropathy Presented at the Hemophilia Parent Support Group Meeting
Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI
Educational Outreach Thromboelastography- Interpretation and How to use data- 63rd and 64th Annual Detroit Trauma Symposum
VWD Regional Roundtable Case discussion with local Hemophilia Treatment Center and private hematologists on the management of patients with von Willebrand disease in the peri-operative or trauma setting at the Sheraton Detroit Metro Airport in Romulus Michigan
2014-Present
2014-Present
2009- Present
Nov 2016
April 2016
Nov 2015
May 2014
Aug 2012
May 2010
Nov 2015 2016
Apr2012
5 SERVICE Community
Heavy Bleeding- a sign of something more serious Your role in detecting Von Willebrand Disease Presentation on Von Willebrand Disease- clinical manifestations pathophysiology and management for local area primary Pediatricians OBGyn and ENT physicians Livonia MI
Educational Outreach Platelet disorders in children Overview of platelet disorders and testing for platelet dysfunction for local area general pediatricians CHM Stilson Center Clinton Township MI
The OBGYNrsquos Role in von Willebrand Disease (VWD) Detection Detroit MI (Presented to OBGyn physicians)
Media Presentations
Treatment Decisions and Clinical Outcomes in Hemophilia B with Inhibitors This educational initiative includes 1 CME vodcast and 1 Clinical Insight and is targeted to Hematologists Hemophilia Treatment Center(HTC) specialists HTC nurses and other clinicians interested in hemophilia treatment and management
ldquoVWD Collaborate to Educate Campaignrdquo launched in partnership with HealthyWomen Media Release and Outreach ndash Media release distributed to more than 12000
journalists Pitched story to 272 print online and broadcast journalists Radio Media Tour ndash Interview with Dr Chitlur and Beth Cahill targeted radio stations in the top 50 markets Matte Release ndash Distributed to more than 10000 news sources reaching VWD patients at the grassroots level Audio News Release ndash Two 60-second audio packages and two 30-second PSA scripts distributed to 12000+ local regional and national radio stations
Scholarly Service
Grant Review Committees
Reviewer of Research Grants for NHLBI- Clinical Trials Review committee- Ad Hoc Reviewer
Mentored Research Awards Abstract Review Committee-HemophiliaThrombosis Research Society (HTRS)
NationalInternational
Invited Member of the Blood Products Advisory Committee (BPAC) - FDA
Editorial Board Membership Haemophilia
Selected by peers to be included in the ldquoBest Doctors in Americardquo database Only 5 of physicians in the United States earn this recognition As part of this affiliation provides consultative services for patients
Jun 2011
Aug 2009
Jun 2009
Apr2012
2015
2013-Present
2015- Present
2014-current
2007-2008 2009-2013
6 Scholarly Service
Review of Manuscripts J of Biomaterials Science Polymer edition Pediatric Blood and Cancer Haemophilia (Editorial Board Member) Journal of Thrombosis Hemostasis Annals of Hematology Thrombosis Research Thrombosis and Haemostasis Pediatrics in Review J of the American Board of Family Medicine
OTHER SERVICE Member of the Steering committee for a multicenter trial on the Real
life use of Extended half life products in patients with hemophilia Baxter ITP Regional Advisory Board Novo Nordisk Translational Advisory Board Baxter Bleed Reduction Advisory Board Baxalta Optimizing Prophylaxis in hemophilia Advisory Board- Chair Baxalta Challenges in Inhibitor management ndash Co-Chair
TEACHING Teaching at Wayne State University
Medical students Year III students while primary attending on HemOnc inpatient unit (1shy2 mosyr)Year IV students on elective rotation in hematologyoncology clinic
ResidentsFellowsInpatientbedside teaching on daily basis while primary attending on 6 West (25-35 mosyr) and while on-call on weekends1-2 lecturesyear on basic coagulation studies and bleeding disordersActively collaborate with residents and students to encourage manuscript writing and clinical studies See pub 13 Case reports31323335 Review articles 39 and Book chapter 6
Faculty (eg CME)ECMO Anticoagulation- Invited seminar at the Joint ICUCV Surgeryconference at Childrens Hospital of Michigan
Thromboelastography- guide to use in anesthesiology Invited seminar atthe CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan
Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital ofMichigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI
Teaching at other institutionsFaculty (eg CME)
Title Laboratory Diagnosis and Therapeutic Monitoring in PediatricHemophilia Avoiding Pifalls Optimizing OutcomesCredits 15 CME Activity Type CME Activity Symposium at the Annual American Society of Pediatric HemaotologyOncology Meeting May 12 2016Description A comprehensive Review of the current issues and challenges related to laboratory assessment of Pedaitric Hemophiliaprovided by GYoung MD DAdcock MD and Meera Chitlur MD
Dec 2016
Aug 2014
Nov 2011
May 2016
7
Faculty (eg CME)Title Hemophilia- A Primer Credits 15 CME Activity Type Online CME ActivityDescription Comprehensive Review of diagnosis and management ofHemophilia by Madhvi Rajpurkar MD and Meera Chitlur MD
Title Differential Diagnosis in a Young Child With Excessive Bleeding Epistaxis and BruisingCredits 075 CME 06 CNE | Expires 62016 Activity Type Online CME ActivityDescription This case-focused learning activity brings together bleedingexperts Mortimer Poncz MD and Meera Chitlur MD to discuss the case of a child born of a non-consanguineous marriage with excessive post-traumatic bleeding and epistaxis
Title Cyberoundsreg Unexplained Bleeding in Hospitalized Patients Credits 10 AMA 10 ANCCActivity Type Online CME ActivityDescription Given the approximately 365 million hospital admissions inthe United States an unexplained bleeding scenario could very well beone that you are required to manage someday Would you know how to handle it Meera B Chitlur- faculty presenter
Title Hemophilia Today What Clinicians Really Want to Knowrdquo Credits 15 CME 15 CNEActivity Type Online CME ActivityDescription This educational activity features three renowned experts inthe field of bleeding disorders Victor S Blanchette MD Meera B Chitlur MD and Steven W Pipe MD address some common gaps inknowledge by providing professional opinion on current and emergingtherapies and clinical challenges associated with managing patients withhemophilia
Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker Cincinnati ChildrenrsquosHospital and Medical center
Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio
Title Current Strategies for the Surgical Management of Patients With Congenital Bleeding DisordersCredits Not for credit Activity Type Online CME ActivityActivity Description Symposium held in conjunction with the 2011 ASPHO (American Society of Pediatric HematologyOncology) AnnualMeeting Victor S Blanchette MD FRCP Steven W Pipe MD and Meera B Chitlur MD Issues pertaining to the perioperative management of patients with congenital bleeding disorders As part oftheir discussion these noted experts address hemophilic and nonshyhemophilic inhibitors of coagulation standard and emerging coagulation tests and novel and experimental clotting factors
Jul 2015
Jul 2015
Nov 2013
Oct 2012
Oct 2012
Dec 2012
May 2011
8
Faculty (eg CME) Apr 2011 Title Treatment Decisions and Clinical Outcomes in Hemophilia B Patients With Inhibitors Credits 075 CME 10 CNE Activity Type Online CME Activity Activity Description In this vodcast learning activity Meera Chitlur MD explains the history prevalence of FIX deficiency and various treatment modalities available She also explores the possible causes for the co-manifestation of inhibitor development and allergic reactions and the usefulness of registries in monitoring the occurrence of inhibitors in patients with hemophilia B
Aug 2010 Global Assays in Hemostasis Invited speaker for Grand Rounds atDevaraj Urs Medical College Kolar Karnataka India
Aug 2009 Title FIX Deficiency and Inhibitors Report From the ISTH-SSC International Registry Credits 075 CME 10 CNE Activity Type Online CME ActivityActivity Description The advent of registry databases to aid collection ofinformation on hemophilia B has helped further the understanding of FIXdeficiency and inhibitors within the scientific community In this learningactivity Meera Chitlur MD discusses the importance of the ISTH-SSCInternational FIX Inhibitor Registry in addition to etiology of severe reactions associated with appearance of inhibitors in hemophilia B
Mentorship 2008DrShilpa Jain MD Mentored research project entitled ldquoThrombin generationin children with moderate to severe hemophiliardquo with year III Pediatric Resident Dr S Jain who was awarded first place in the Resident Research Competition 2009DrBMehta PGY2 mentor for research project on thrombin generation inpatients on Ventricular Assist Devicersquos 2009 2009-2011 Dr S Veluswamy Mentor to PGY3 resident 2012-2014 DrAbdullah Mentor to PGY2 resident 2012-2013 DrsAyesha Zia MD Fellow Mentor for fellow projects 2010-2013 DrLRao MD Fellow Clinical and Research Mentor 2013-2015 DrTSarkar Fellow Research mentor 2005Visiting professorscientists DrDSosothikul from Thailand 2007-2008
DrAlphan Kupesiz from Turkey May 2013 DrMaissaa Janbain MD Tulane University Externship mentor April 2013 Dr Indrayas Woldie MD Karmanos Cancer Institute WSU May2015 DrJing Christine Ye MD Karmanos Cancer Institute WSU July 2015 Dr Yasmina Abajas University of North Carolina Global Assays Training 2016-2017 Dr Katherine Regling PGY2-3 2016-2018 DrBettina Joi Isaac Fellow Research mentor 2016-2018 DrSarah Ramiz Fellow Research mentor
GRANTS CONTRACTS AND OTHER FUNDING
Active Grants and Contracts Role Site Principal Investigator Title Cascade Hemophilia Consortium Grant Sponsor Cascade Hemophilia Consortium
9 Trial StartEnc Date 6115-53116 (renewed yearly) Funding $221161
Active Grants and Contracts Role Site Principal Investigator Title My Life Our Future (MLOF2) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Period of Support 1115-123115 Funding Direct cost $1468 Indirect cost $38
Role Site Principal Investigator Title Validation of the ISTH-BAT (International Society on Thrombosis and Haemostasis Bleeding Assessment Tool) in Hemophilia Carriers Sponsor Queenrsquos University Grant StartEnd Date 32014-12016 Funding Direct cost $5750 Indirect cost $910
Role Site Principal Investigator Title Maternal and Child Health Bureau (MCHB) Comprehensive Care Sponsor Maternal and Child Health Bureau Grant StartEnd date 2014-2015 (renewed yearly) Funding $35000
Role Site Principal Investigator Title My Life Our Future (MLOF) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Trial StartEnc Date 12914-12816 Funding Direct cost $2748 Indirect cost $752
Role Co Investigator Title Hemophilia Inhibitor Research Study Ph III (HIRS) Site PI MRajpurkar MD Source Center for Disease Control Period of Support 1092014 ndash 9302015 Direct costs $20340 (based on enrollment)
Role Site Principal Investigator Title Hemophilia Foundation of MI Sponsor ATHN Trial StartEnc Date 9302014-92915 (renewed yearly) Funding $37000
Role Co Investigator Title Molecular and clinical biology of von Willebrandrsquos Disease (Zimmerman project) Source National Institutes of Science (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of Support 20114-013117 Direct Cost $16413 (Based on enrollment)
10
Active Grants and Contracts
Role Co Investigator Title Comparative Effectiveness in the Diagnosis of vWD Source National Institutes of Health (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of support 2114-13117 Direct Cost $33534 (Based on enrollment)
Role Co-Investigator Title Multicenter Evaluation of the Duration of Therapy for Thrombosis in Children Site PI MRajpurkar Source All Childrens Research Institute Inc Period of Support 01012014-12312018 Direct cost $9230
Role Site Principal Investigator Title Personalized Medicine in Hemophilia Sponsor Childrens Hospital of Los Angeles Trial StartEnc Date 7113-63016 Funding Direct cost $33041 Indirect cost $17181
Role Principal Investigator Title Regional and Cultural Variance in Perceptions Pertaining to Research Participation Sponsor None Trial StartEnd Date 0513-122015 Funding NA
Role Principal Investigator Percent Effort 20 Title Thromboelastography in Severe Hemophilia Following Clotting Factor Replacement Therapy The primary objective is to evaluate the utility of Thromboelastography in the assessment of pharmacokinetics after factor replacement in patients with severemoderately severe hemophilia Sponsor Childrens Research Center of Michigan Grant StartEnd Date 22008- 122015 (closed to enrollment Data analysis ongoing) Funding Direct cost $45910 Indirect cost 1069342
Role Site PI Title Pediatric and adult intercontinental registry on chronic ITP Sponsor University Childrenrsquos Hospital Basel Switzerland Trial StartEnd Date 404 to 62016 80 patients entered to date from our Center Funding NA
Role Co- Investigator Title A Randomized Open-Label Active Controlled Safety and Extrapolated Efficacy Study in Pediatric Subjects Requiring Anticoagulation for the Treatment of a Venous Thromboembolic Event Source Pfizer Inc
11 Period of support 612015- 5312020 Total Direct Cost $63802 (based on enrollment)
Clinical Trials Activities Role Site Principal Investigator Title Use of rFXIII in treatment of congenital FXIII deficiency a prospective multi-centre observational study- MENTOR 6 (25RGV) Sponsor Novo Nordisk Trial StartEnd Date 11515-11417 Funding $25611
Role Site Principal Investigator Title Study of Prophylaxis ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated with ADVATE or RIXUBIS (SPACE) (25RE7) Sponsor Baxter Healthcare Corp Trial startEnd Date 12914-12816 Funding Direct cost $9541 Indirect cost $2481 (based on patient enrollment)
Role Co Investigator Title Oral Rivaroxaban in children with venous thrombosis a 30 day open label active controlled randomized study of the safety efficacy and the pharmacokinetic and pharmacodynamic properties of oral rivaroxaban in children with venous thrombosis Source Bayer Corporation Period of support 062314- 04082016 Total Direct Cost 74352
Role Co Investigator Title An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune (Idiopathic) Thrombocytopenia Purpura (ITP) Site PI MCallaghan Sponsor Amgen Inc Trial StartEnd Date 032213 - 32118 Funding $130870
Role Site Principal- Investigator Title PH3 NN7088-3859 A Multi-National Trial Evaluating Safety and Efficacy Including Pharmacokinetics of NNC 0159-0000-1003 when Administered for Treatment and Prophylaxis of Bleeding in Patients with Haemophilia A - Pathfinder N8 GP (25QPY) Sponsor Novo Nordisk Trial startEnd Date 11813- 102121 Funding Direct cost $61538 Indirect cost $16000
Role Co- Primary Investigator Title Safety and Efficacy of NNC 0155-0000-0004 in Prevention and Treatment of Bleeds in Pediatric Previously Untreated Patients with Haemophilia A (Guardian) N8 PUPs Source Novo Nordisk Period of support 091212- 04082016 Total Cost $15270 (based on enrollment)
12
Clinical Trials Activities Role Co-Investigator Title Rescue Immune-tolerance Study in ITI Experienced Patients shyResist Experienced Source City of Hope Period of support 08152012-02122015 (Study is closed to accrual but following subjects enrolled) Direct Cost$ 5750
Role Co Investigator Title Single-dose pilot study of rivaroxaban in pediatric subjects with venous thromboembolism-12892 Source Bayer Corporation Site PI MRajpurkar Period of Support 061512-123115 Total Direct Cost $83961 (based on enrollment)
Role Co-investigator Title A Phase 3 Randomized Double Blind Placebo Controlled Study to Determine the Safety and Efficacy of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune Thrombocytopenia (ITP) Principal Investigator M Callaghan Sponsor Amgen Inc Trial StartEnd Date 1211-0414 Funding $56000
Role Co Investigator Title - A Three Month Prospective Open Label Study of Therapy with FRAGMINreg (Dalteparin Sodium Injection) in Children with Malignancies and Venous Thromboembolism - FRAG-A001-201 Source Easai Inc Site PI MRajpurkar Period of Support 092810 - 052115 Total Direct Cost$5285742
Role Site Principal Investigator Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (25PYE) Sponsor Novo Nordisk Inc Trial startEnd Date 22309-122115 Funding Direct cost $44005 Indirect cost $11441
Completed Studies
Role Site Principal Investigator Title Evaluate the Activity a Site Specific of BDomain Deleted (BDD) Pegylated Recombinant FVIII Protein (BAY 94-9027) in Plasma Samples Measured with both Chromogenic and One Stage Assays Sponsor Bayer Trial StartEnc Date 8115- 8116 Funding $696400
13 Completed Studies
Role Co-investigator Title Safety and Efficacy of N8 in prevention and treatment of bleeds in pediatric Previously treated patients with Hemophilia A Site PI MRajpurkar Sponsor Novo Nordisk Trial StartEnd Date 1210 to 911 Funding $381729
Role Site PI Title 3760- Phase 3b Trial Investigating the Pharmacokinetics amp Safety Profile of Single IV Dose of rFXIII in Paediatric (1 to less than 6 Years Old) Subjects with Congenital FXIII A-Subunit Deficiency Sponsor Novo Nordisk Inc Trial StartEnd Date 1110-0112 Funding $ 4315752
Role Co-investigator Title Universal data and serum specimen collection (UDC) system for hemophilia Sponsor Centers for Disease Control (CDC) Site PI JLusher Trial StartEnd Date 0610 to 511 Funding $48000
Role Site PI for multi center trial Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (N13 3720) (Mentor 2) Sponsor Novo Nordisk Inc Trial StartEnd Date 0410- 1214 Funding $ 5544504
Role Principal Investigator Title Prospective ADVATE ITI Registry (Pair) Sponsor Baxter Trial StartEnd Date 210 -411 Funding $2000
Role Co-investigator Title Mechanisms of Race Based Differences in Factor VIII Immunogenicity in Hemophilia Sponsor NIH Supleveda Site PI JLusher Trial StartEnd Date 0909 to 0911 Funding $70000
Role Co-investigator Title Treatment of Congenital Factor VII deficiency A prospective observational studySTER [Seven Deficiency Treatment Registry] Site PI MRajpurkar Sponsor Quintiles Inc Trial StartEnd Date 709 to 1210 Funding $2800
14 Completed Studies
Role Site PI for multi center trial Title Prophylaxis Patient Case Collection (PRO-PACT) Sponsor Novo Nordisk Inc Trial StartEnd Date 409-0510 Funding $3984
Role Co-investigator Title Phase 1 Prospective Randomized Crossover Study to Compare the Pharmacokinetics and Safety of rAHF-PFM Reconstituted in 2mL versus 5mL SWFI in Previously Treated Severe Hemophilia A Patients Site PI JLusher Sponsor Baxter BioScience Trial StartEnd Date 208- 310 Funding $34272
Role Consultant Title Thromboelastographic evaluation of hypercoagulability after Fontanrsquos surgery Site PI MRajpurkar Sponsor CRCM Trial StartEnd Date 706 to 1210 Funding $ 32507
Role Site PI Title Recombinant anti-hemophilic factor manufactured and formulated without added human or animal proteins (rAHF PFM) evaluation of immunogenicity efficacy and safety in previously untreated patients with hemophilia A (PUP study) Sponsor Baxter Bioscience Trial StartEnd Date 404-0909 Funding $32582
Role Co-investigator Title Chiron Gene Therapy Long Term Safety Follow-up Site PI JLusher Sponsor Chiron Corp Trial StartEnd Date 0800 to 1210 Funding $1771
PUBLICATIONS Peer-Reviewed Publications
Reports of Original Work Notes Trainee or student mentored by MC Citation data from Web of Science
1 Iorio A Keepanasseril A Foster G Navarro-Ruan T McEneny-King A Edginton AN Thabane L WAPPS-Hemo co-investigator network Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Study Protocol JMIR Res Protoc 2016 Dec 155(4)e239
2 James PD Mahlangu J Bidlingmaier C Mingot-Castellano ME Chitlur M Fogarty PF Cuker A Mancuso ME Holme PA Grabell J Satkunam N Hopman WM Mathew P Global Emerging HEmostasis Experts Panel (GEHEP) Evaluation of the utility of the ISTH-BAT in haemophilia carriers a multinational studyHaemophilia 2016 Nov22(6)912-918
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
2 MAJOR PROFESSIONAL SOCIETIES American Society of Hematology Hemophilia and Thrombosis Research Society International Society of Thrombosis and Hemostasis MEDICAL LICENSURE State of Michigan MedicalPharmacy License 4301 063540
BOARD CERTIFICATION Pediatric hematologyoncology
HONORSAWARDS Resident Teaching award (Associate Professor)
Selected by peers for inclusion in Hour Detroit magazines list of Top Docs
Elected to the Board of Directors of the Hemophilia and Thrombosis Research Society (HTRS)
Nominated for the 2015 ldquoAmericarsquos Best Physiciansrdquo directory-nominated by physicians recognizes top professionals with superior credentials experience exceptional patient care and commitment to excellence
Biography selected for Marquis Whos Who In Science and Engineering
Elected to membership on the National Hemophilia Foundations Medical and Scientific Advisory Council
Barnhart-Lusher Hemostasis Research Endowed Chair
College Teaching Award in the WSU School of Medicine
Recognized by peer review survey for inclusion in ldquoDetroit Super Doctorsrdquo featuring only 5 of physicians in the Detroit area by the Detroit News and Detroit Free Press websites
Recognized by patientsparents as ldquoMetro Parent Mom-Approved Docrdquo
Recognized as a 2011 ldquoPatientsrsquo Choicerdquo Physician of the nations 720000 active physicians only 5 were accorded this honor by their patients
Biography inclusion in the 66th Edition of Whorsquos Who in America
Certificate of Recognition for support amp mentorship of pediatric resident research
Recognized by peer review survey for inclusion in ldquoBest Docrsquos In Americardquo database
Wolf Zuelzer Award for best research during fellowship 3rd Place
Jan 2019
Dec 2019
2016
2016
2015- Present
2015
2015-2017
2014- Present
2013- Present
2012
2011-2014
2011
2011
2012-2015
2008
2007-2016
2004
3 SERVICE Affiliate medical organizations Member of the Clinical Competence Committee of the Pediatric HematologyOncology Fellowship Program Review and assessment of fellow clinical performance and provide recommendations to the fellowship program July 2014- Present director Director of Childrenrsquos Hospital Special Coagulation Laboratory Provides administrative oversight Responsible for maintaining Quality Control College of American Pathologists and CLIA certification Involved in new test Jul 2013-Present development and provides formal reports of platelet aggregation studies and thromboelastography reports for all patients Conduct weekly meeting of coagulation lab staff fellows and Staff physicians
Director Hemophilia Treatment Center and Hemostasis program Childrens Hospital of Michigan Provides administrative oversight Responsible for Sept 2011- Present protocol development and review of management Involved in the development of policies and procedures for patient care process improvement and patient satisfaction Responsible for administration of the PHS program including financial oversight and management Member of the Ambulatory Operations leadership council Involved with optimization of the clinic flow and quality improvement projects associated with day to day outpatient clinic operations and scheduling Regularly 2012-2014 attends bi-monthly meetings with pediatric administration to provide departmental input and also ensures implementation of policies approved at meetings Member of the In-patient distribution working group Pediatric Hematologyoncology representative at the working group addressing 2012-2014 patient distribution on in-patient units Involved with development of policies and procedures pertaining to better utilization of resident teams and physicians
SERVICE Professional August 2016- Present Invited member of the International Society if Thrombosis and Hemostasis(ISTH) Education Committee Invited member of the HTRS Publications committee August 2016- Present Invited Member of the Blood Products Advisory Committee (BPAC) of the FDA 2015-Present ModeratorChair of Scientific Session on Treatment of Acquired Hemostatic June 2015 Disorders at the International Society Of Thrombosis and Hemostasis (ISTH) Society Annual Meeting June 2015 Member of the Board of Directors for the Hemophilia and Thrombosis Apr 2015-Present Research Society (HTRS) Elected to the Board of Directors of the national research group for having developed nationally recognized expertise in hemostasis Member of the Medical and Scientific Advisory Committee (MASAC) of the 2014- Present National Hemophilia Foundation Invited member Nationally recognized for the development of national guidelines and recommendations for the management of patients with bleeding disorders
4 SERVICE Professional
Board member of the Intercontinental Cooperative ITP Study Group (ICIS) Manuscript writing and data collection by the International collaborative group
Member of The Women amp Girls with Blood Disorders (WGBD) Learning Action Network (LAN) for healthcare professionals Invited member Instrumental in the development of National Collaborative Research projects in Women and Girls with Bleeding disorders International Society of Thrombosis and Hemostasis ndash Co-chair of the FVIIIFIX subcommittee Working Party on Standardization of 2012-2014 Thromboelastography Developed the international recommendations for Standardization of Thromboelastography Chairman of the International TEG-ROTEM Working Group Instrumental in 2006-Present developing standardization and provided international guidance to methodology and validation Member of the Global Emerging HEmophilia Panel (GEHEP) Project leader and co-investigator for multiple projects with an International group of Researchers who actively conduct Research in Hemophilia and hemostasis
SERVICE Community
Presentation for lay audiences
Glanzmann Thrombasthenia 101 Invited by Comprehensive Health Education Services LLC a Not-for-profit company involved with providing health education to familiespatients to help patients and families of patients with Glanzmann Thrombasthenia obtain knowledge about the diagnosis
Von Willebrand Disease- Diagnosis and Treatment HFM Springfest
Von Willebrand Disease Treatment options- Midwest Regional VWD Conference
Treatment Options for Joint Disease in Hemophilia Presented at Hemophilia Foundation of Michigan-Springfest
Hemarthrosis in Hemophilia- Importance of prophylaxis in prevention of hemophilic arthropathy Presented at the Hemophilia Parent Support Group Meeting
Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI
Educational Outreach Thromboelastography- Interpretation and How to use data- 63rd and 64th Annual Detroit Trauma Symposum
VWD Regional Roundtable Case discussion with local Hemophilia Treatment Center and private hematologists on the management of patients with von Willebrand disease in the peri-operative or trauma setting at the Sheraton Detroit Metro Airport in Romulus Michigan
2014-Present
2014-Present
2009- Present
Nov 2016
April 2016
Nov 2015
May 2014
Aug 2012
May 2010
Nov 2015 2016
Apr2012
5 SERVICE Community
Heavy Bleeding- a sign of something more serious Your role in detecting Von Willebrand Disease Presentation on Von Willebrand Disease- clinical manifestations pathophysiology and management for local area primary Pediatricians OBGyn and ENT physicians Livonia MI
Educational Outreach Platelet disorders in children Overview of platelet disorders and testing for platelet dysfunction for local area general pediatricians CHM Stilson Center Clinton Township MI
The OBGYNrsquos Role in von Willebrand Disease (VWD) Detection Detroit MI (Presented to OBGyn physicians)
Media Presentations
Treatment Decisions and Clinical Outcomes in Hemophilia B with Inhibitors This educational initiative includes 1 CME vodcast and 1 Clinical Insight and is targeted to Hematologists Hemophilia Treatment Center(HTC) specialists HTC nurses and other clinicians interested in hemophilia treatment and management
ldquoVWD Collaborate to Educate Campaignrdquo launched in partnership with HealthyWomen Media Release and Outreach ndash Media release distributed to more than 12000
journalists Pitched story to 272 print online and broadcast journalists Radio Media Tour ndash Interview with Dr Chitlur and Beth Cahill targeted radio stations in the top 50 markets Matte Release ndash Distributed to more than 10000 news sources reaching VWD patients at the grassroots level Audio News Release ndash Two 60-second audio packages and two 30-second PSA scripts distributed to 12000+ local regional and national radio stations
Scholarly Service
Grant Review Committees
Reviewer of Research Grants for NHLBI- Clinical Trials Review committee- Ad Hoc Reviewer
Mentored Research Awards Abstract Review Committee-HemophiliaThrombosis Research Society (HTRS)
NationalInternational
Invited Member of the Blood Products Advisory Committee (BPAC) - FDA
Editorial Board Membership Haemophilia
Selected by peers to be included in the ldquoBest Doctors in Americardquo database Only 5 of physicians in the United States earn this recognition As part of this affiliation provides consultative services for patients
Jun 2011
Aug 2009
Jun 2009
Apr2012
2015
2013-Present
2015- Present
2014-current
2007-2008 2009-2013
6 Scholarly Service
Review of Manuscripts J of Biomaterials Science Polymer edition Pediatric Blood and Cancer Haemophilia (Editorial Board Member) Journal of Thrombosis Hemostasis Annals of Hematology Thrombosis Research Thrombosis and Haemostasis Pediatrics in Review J of the American Board of Family Medicine
OTHER SERVICE Member of the Steering committee for a multicenter trial on the Real
life use of Extended half life products in patients with hemophilia Baxter ITP Regional Advisory Board Novo Nordisk Translational Advisory Board Baxter Bleed Reduction Advisory Board Baxalta Optimizing Prophylaxis in hemophilia Advisory Board- Chair Baxalta Challenges in Inhibitor management ndash Co-Chair
TEACHING Teaching at Wayne State University
Medical students Year III students while primary attending on HemOnc inpatient unit (1shy2 mosyr)Year IV students on elective rotation in hematologyoncology clinic
ResidentsFellowsInpatientbedside teaching on daily basis while primary attending on 6 West (25-35 mosyr) and while on-call on weekends1-2 lecturesyear on basic coagulation studies and bleeding disordersActively collaborate with residents and students to encourage manuscript writing and clinical studies See pub 13 Case reports31323335 Review articles 39 and Book chapter 6
Faculty (eg CME)ECMO Anticoagulation- Invited seminar at the Joint ICUCV Surgeryconference at Childrens Hospital of Michigan
Thromboelastography- guide to use in anesthesiology Invited seminar atthe CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan
Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital ofMichigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI
Teaching at other institutionsFaculty (eg CME)
Title Laboratory Diagnosis and Therapeutic Monitoring in PediatricHemophilia Avoiding Pifalls Optimizing OutcomesCredits 15 CME Activity Type CME Activity Symposium at the Annual American Society of Pediatric HemaotologyOncology Meeting May 12 2016Description A comprehensive Review of the current issues and challenges related to laboratory assessment of Pedaitric Hemophiliaprovided by GYoung MD DAdcock MD and Meera Chitlur MD
Dec 2016
Aug 2014
Nov 2011
May 2016
7
Faculty (eg CME)Title Hemophilia- A Primer Credits 15 CME Activity Type Online CME ActivityDescription Comprehensive Review of diagnosis and management ofHemophilia by Madhvi Rajpurkar MD and Meera Chitlur MD
Title Differential Diagnosis in a Young Child With Excessive Bleeding Epistaxis and BruisingCredits 075 CME 06 CNE | Expires 62016 Activity Type Online CME ActivityDescription This case-focused learning activity brings together bleedingexperts Mortimer Poncz MD and Meera Chitlur MD to discuss the case of a child born of a non-consanguineous marriage with excessive post-traumatic bleeding and epistaxis
Title Cyberoundsreg Unexplained Bleeding in Hospitalized Patients Credits 10 AMA 10 ANCCActivity Type Online CME ActivityDescription Given the approximately 365 million hospital admissions inthe United States an unexplained bleeding scenario could very well beone that you are required to manage someday Would you know how to handle it Meera B Chitlur- faculty presenter
Title Hemophilia Today What Clinicians Really Want to Knowrdquo Credits 15 CME 15 CNEActivity Type Online CME ActivityDescription This educational activity features three renowned experts inthe field of bleeding disorders Victor S Blanchette MD Meera B Chitlur MD and Steven W Pipe MD address some common gaps inknowledge by providing professional opinion on current and emergingtherapies and clinical challenges associated with managing patients withhemophilia
Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker Cincinnati ChildrenrsquosHospital and Medical center
Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio
Title Current Strategies for the Surgical Management of Patients With Congenital Bleeding DisordersCredits Not for credit Activity Type Online CME ActivityActivity Description Symposium held in conjunction with the 2011 ASPHO (American Society of Pediatric HematologyOncology) AnnualMeeting Victor S Blanchette MD FRCP Steven W Pipe MD and Meera B Chitlur MD Issues pertaining to the perioperative management of patients with congenital bleeding disorders As part oftheir discussion these noted experts address hemophilic and nonshyhemophilic inhibitors of coagulation standard and emerging coagulation tests and novel and experimental clotting factors
Jul 2015
Jul 2015
Nov 2013
Oct 2012
Oct 2012
Dec 2012
May 2011
8
Faculty (eg CME) Apr 2011 Title Treatment Decisions and Clinical Outcomes in Hemophilia B Patients With Inhibitors Credits 075 CME 10 CNE Activity Type Online CME Activity Activity Description In this vodcast learning activity Meera Chitlur MD explains the history prevalence of FIX deficiency and various treatment modalities available She also explores the possible causes for the co-manifestation of inhibitor development and allergic reactions and the usefulness of registries in monitoring the occurrence of inhibitors in patients with hemophilia B
Aug 2010 Global Assays in Hemostasis Invited speaker for Grand Rounds atDevaraj Urs Medical College Kolar Karnataka India
Aug 2009 Title FIX Deficiency and Inhibitors Report From the ISTH-SSC International Registry Credits 075 CME 10 CNE Activity Type Online CME ActivityActivity Description The advent of registry databases to aid collection ofinformation on hemophilia B has helped further the understanding of FIXdeficiency and inhibitors within the scientific community In this learningactivity Meera Chitlur MD discusses the importance of the ISTH-SSCInternational FIX Inhibitor Registry in addition to etiology of severe reactions associated with appearance of inhibitors in hemophilia B
Mentorship 2008DrShilpa Jain MD Mentored research project entitled ldquoThrombin generationin children with moderate to severe hemophiliardquo with year III Pediatric Resident Dr S Jain who was awarded first place in the Resident Research Competition 2009DrBMehta PGY2 mentor for research project on thrombin generation inpatients on Ventricular Assist Devicersquos 2009 2009-2011 Dr S Veluswamy Mentor to PGY3 resident 2012-2014 DrAbdullah Mentor to PGY2 resident 2012-2013 DrsAyesha Zia MD Fellow Mentor for fellow projects 2010-2013 DrLRao MD Fellow Clinical and Research Mentor 2013-2015 DrTSarkar Fellow Research mentor 2005Visiting professorscientists DrDSosothikul from Thailand 2007-2008
DrAlphan Kupesiz from Turkey May 2013 DrMaissaa Janbain MD Tulane University Externship mentor April 2013 Dr Indrayas Woldie MD Karmanos Cancer Institute WSU May2015 DrJing Christine Ye MD Karmanos Cancer Institute WSU July 2015 Dr Yasmina Abajas University of North Carolina Global Assays Training 2016-2017 Dr Katherine Regling PGY2-3 2016-2018 DrBettina Joi Isaac Fellow Research mentor 2016-2018 DrSarah Ramiz Fellow Research mentor
GRANTS CONTRACTS AND OTHER FUNDING
Active Grants and Contracts Role Site Principal Investigator Title Cascade Hemophilia Consortium Grant Sponsor Cascade Hemophilia Consortium
9 Trial StartEnc Date 6115-53116 (renewed yearly) Funding $221161
Active Grants and Contracts Role Site Principal Investigator Title My Life Our Future (MLOF2) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Period of Support 1115-123115 Funding Direct cost $1468 Indirect cost $38
Role Site Principal Investigator Title Validation of the ISTH-BAT (International Society on Thrombosis and Haemostasis Bleeding Assessment Tool) in Hemophilia Carriers Sponsor Queenrsquos University Grant StartEnd Date 32014-12016 Funding Direct cost $5750 Indirect cost $910
Role Site Principal Investigator Title Maternal and Child Health Bureau (MCHB) Comprehensive Care Sponsor Maternal and Child Health Bureau Grant StartEnd date 2014-2015 (renewed yearly) Funding $35000
Role Site Principal Investigator Title My Life Our Future (MLOF) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Trial StartEnc Date 12914-12816 Funding Direct cost $2748 Indirect cost $752
Role Co Investigator Title Hemophilia Inhibitor Research Study Ph III (HIRS) Site PI MRajpurkar MD Source Center for Disease Control Period of Support 1092014 ndash 9302015 Direct costs $20340 (based on enrollment)
Role Site Principal Investigator Title Hemophilia Foundation of MI Sponsor ATHN Trial StartEnc Date 9302014-92915 (renewed yearly) Funding $37000
Role Co Investigator Title Molecular and clinical biology of von Willebrandrsquos Disease (Zimmerman project) Source National Institutes of Science (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of Support 20114-013117 Direct Cost $16413 (Based on enrollment)
10
Active Grants and Contracts
Role Co Investigator Title Comparative Effectiveness in the Diagnosis of vWD Source National Institutes of Health (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of support 2114-13117 Direct Cost $33534 (Based on enrollment)
Role Co-Investigator Title Multicenter Evaluation of the Duration of Therapy for Thrombosis in Children Site PI MRajpurkar Source All Childrens Research Institute Inc Period of Support 01012014-12312018 Direct cost $9230
Role Site Principal Investigator Title Personalized Medicine in Hemophilia Sponsor Childrens Hospital of Los Angeles Trial StartEnc Date 7113-63016 Funding Direct cost $33041 Indirect cost $17181
Role Principal Investigator Title Regional and Cultural Variance in Perceptions Pertaining to Research Participation Sponsor None Trial StartEnd Date 0513-122015 Funding NA
Role Principal Investigator Percent Effort 20 Title Thromboelastography in Severe Hemophilia Following Clotting Factor Replacement Therapy The primary objective is to evaluate the utility of Thromboelastography in the assessment of pharmacokinetics after factor replacement in patients with severemoderately severe hemophilia Sponsor Childrens Research Center of Michigan Grant StartEnd Date 22008- 122015 (closed to enrollment Data analysis ongoing) Funding Direct cost $45910 Indirect cost 1069342
Role Site PI Title Pediatric and adult intercontinental registry on chronic ITP Sponsor University Childrenrsquos Hospital Basel Switzerland Trial StartEnd Date 404 to 62016 80 patients entered to date from our Center Funding NA
Role Co- Investigator Title A Randomized Open-Label Active Controlled Safety and Extrapolated Efficacy Study in Pediatric Subjects Requiring Anticoagulation for the Treatment of a Venous Thromboembolic Event Source Pfizer Inc
11 Period of support 612015- 5312020 Total Direct Cost $63802 (based on enrollment)
Clinical Trials Activities Role Site Principal Investigator Title Use of rFXIII in treatment of congenital FXIII deficiency a prospective multi-centre observational study- MENTOR 6 (25RGV) Sponsor Novo Nordisk Trial StartEnd Date 11515-11417 Funding $25611
Role Site Principal Investigator Title Study of Prophylaxis ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated with ADVATE or RIXUBIS (SPACE) (25RE7) Sponsor Baxter Healthcare Corp Trial startEnd Date 12914-12816 Funding Direct cost $9541 Indirect cost $2481 (based on patient enrollment)
Role Co Investigator Title Oral Rivaroxaban in children with venous thrombosis a 30 day open label active controlled randomized study of the safety efficacy and the pharmacokinetic and pharmacodynamic properties of oral rivaroxaban in children with venous thrombosis Source Bayer Corporation Period of support 062314- 04082016 Total Direct Cost 74352
Role Co Investigator Title An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune (Idiopathic) Thrombocytopenia Purpura (ITP) Site PI MCallaghan Sponsor Amgen Inc Trial StartEnd Date 032213 - 32118 Funding $130870
Role Site Principal- Investigator Title PH3 NN7088-3859 A Multi-National Trial Evaluating Safety and Efficacy Including Pharmacokinetics of NNC 0159-0000-1003 when Administered for Treatment and Prophylaxis of Bleeding in Patients with Haemophilia A - Pathfinder N8 GP (25QPY) Sponsor Novo Nordisk Trial startEnd Date 11813- 102121 Funding Direct cost $61538 Indirect cost $16000
Role Co- Primary Investigator Title Safety and Efficacy of NNC 0155-0000-0004 in Prevention and Treatment of Bleeds in Pediatric Previously Untreated Patients with Haemophilia A (Guardian) N8 PUPs Source Novo Nordisk Period of support 091212- 04082016 Total Cost $15270 (based on enrollment)
12
Clinical Trials Activities Role Co-Investigator Title Rescue Immune-tolerance Study in ITI Experienced Patients shyResist Experienced Source City of Hope Period of support 08152012-02122015 (Study is closed to accrual but following subjects enrolled) Direct Cost$ 5750
Role Co Investigator Title Single-dose pilot study of rivaroxaban in pediatric subjects with venous thromboembolism-12892 Source Bayer Corporation Site PI MRajpurkar Period of Support 061512-123115 Total Direct Cost $83961 (based on enrollment)
Role Co-investigator Title A Phase 3 Randomized Double Blind Placebo Controlled Study to Determine the Safety and Efficacy of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune Thrombocytopenia (ITP) Principal Investigator M Callaghan Sponsor Amgen Inc Trial StartEnd Date 1211-0414 Funding $56000
Role Co Investigator Title - A Three Month Prospective Open Label Study of Therapy with FRAGMINreg (Dalteparin Sodium Injection) in Children with Malignancies and Venous Thromboembolism - FRAG-A001-201 Source Easai Inc Site PI MRajpurkar Period of Support 092810 - 052115 Total Direct Cost$5285742
Role Site Principal Investigator Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (25PYE) Sponsor Novo Nordisk Inc Trial startEnd Date 22309-122115 Funding Direct cost $44005 Indirect cost $11441
Completed Studies
Role Site Principal Investigator Title Evaluate the Activity a Site Specific of BDomain Deleted (BDD) Pegylated Recombinant FVIII Protein (BAY 94-9027) in Plasma Samples Measured with both Chromogenic and One Stage Assays Sponsor Bayer Trial StartEnc Date 8115- 8116 Funding $696400
13 Completed Studies
Role Co-investigator Title Safety and Efficacy of N8 in prevention and treatment of bleeds in pediatric Previously treated patients with Hemophilia A Site PI MRajpurkar Sponsor Novo Nordisk Trial StartEnd Date 1210 to 911 Funding $381729
Role Site PI Title 3760- Phase 3b Trial Investigating the Pharmacokinetics amp Safety Profile of Single IV Dose of rFXIII in Paediatric (1 to less than 6 Years Old) Subjects with Congenital FXIII A-Subunit Deficiency Sponsor Novo Nordisk Inc Trial StartEnd Date 1110-0112 Funding $ 4315752
Role Co-investigator Title Universal data and serum specimen collection (UDC) system for hemophilia Sponsor Centers for Disease Control (CDC) Site PI JLusher Trial StartEnd Date 0610 to 511 Funding $48000
Role Site PI for multi center trial Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (N13 3720) (Mentor 2) Sponsor Novo Nordisk Inc Trial StartEnd Date 0410- 1214 Funding $ 5544504
Role Principal Investigator Title Prospective ADVATE ITI Registry (Pair) Sponsor Baxter Trial StartEnd Date 210 -411 Funding $2000
Role Co-investigator Title Mechanisms of Race Based Differences in Factor VIII Immunogenicity in Hemophilia Sponsor NIH Supleveda Site PI JLusher Trial StartEnd Date 0909 to 0911 Funding $70000
Role Co-investigator Title Treatment of Congenital Factor VII deficiency A prospective observational studySTER [Seven Deficiency Treatment Registry] Site PI MRajpurkar Sponsor Quintiles Inc Trial StartEnd Date 709 to 1210 Funding $2800
14 Completed Studies
Role Site PI for multi center trial Title Prophylaxis Patient Case Collection (PRO-PACT) Sponsor Novo Nordisk Inc Trial StartEnd Date 409-0510 Funding $3984
Role Co-investigator Title Phase 1 Prospective Randomized Crossover Study to Compare the Pharmacokinetics and Safety of rAHF-PFM Reconstituted in 2mL versus 5mL SWFI in Previously Treated Severe Hemophilia A Patients Site PI JLusher Sponsor Baxter BioScience Trial StartEnd Date 208- 310 Funding $34272
Role Consultant Title Thromboelastographic evaluation of hypercoagulability after Fontanrsquos surgery Site PI MRajpurkar Sponsor CRCM Trial StartEnd Date 706 to 1210 Funding $ 32507
Role Site PI Title Recombinant anti-hemophilic factor manufactured and formulated without added human or animal proteins (rAHF PFM) evaluation of immunogenicity efficacy and safety in previously untreated patients with hemophilia A (PUP study) Sponsor Baxter Bioscience Trial StartEnd Date 404-0909 Funding $32582
Role Co-investigator Title Chiron Gene Therapy Long Term Safety Follow-up Site PI JLusher Sponsor Chiron Corp Trial StartEnd Date 0800 to 1210 Funding $1771
PUBLICATIONS Peer-Reviewed Publications
Reports of Original Work Notes Trainee or student mentored by MC Citation data from Web of Science
1 Iorio A Keepanasseril A Foster G Navarro-Ruan T McEneny-King A Edginton AN Thabane L WAPPS-Hemo co-investigator network Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Study Protocol JMIR Res Protoc 2016 Dec 155(4)e239
2 James PD Mahlangu J Bidlingmaier C Mingot-Castellano ME Chitlur M Fogarty PF Cuker A Mancuso ME Holme PA Grabell J Satkunam N Hopman WM Mathew P Global Emerging HEmostasis Experts Panel (GEHEP) Evaluation of the utility of the ISTH-BAT in haemophilia carriers a multinational studyHaemophilia 2016 Nov22(6)912-918
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
3 SERVICE Affiliate medical organizations Member of the Clinical Competence Committee of the Pediatric HematologyOncology Fellowship Program Review and assessment of fellow clinical performance and provide recommendations to the fellowship program July 2014- Present director Director of Childrenrsquos Hospital Special Coagulation Laboratory Provides administrative oversight Responsible for maintaining Quality Control College of American Pathologists and CLIA certification Involved in new test Jul 2013-Present development and provides formal reports of platelet aggregation studies and thromboelastography reports for all patients Conduct weekly meeting of coagulation lab staff fellows and Staff physicians
Director Hemophilia Treatment Center and Hemostasis program Childrens Hospital of Michigan Provides administrative oversight Responsible for Sept 2011- Present protocol development and review of management Involved in the development of policies and procedures for patient care process improvement and patient satisfaction Responsible for administration of the PHS program including financial oversight and management Member of the Ambulatory Operations leadership council Involved with optimization of the clinic flow and quality improvement projects associated with day to day outpatient clinic operations and scheduling Regularly 2012-2014 attends bi-monthly meetings with pediatric administration to provide departmental input and also ensures implementation of policies approved at meetings Member of the In-patient distribution working group Pediatric Hematologyoncology representative at the working group addressing 2012-2014 patient distribution on in-patient units Involved with development of policies and procedures pertaining to better utilization of resident teams and physicians
SERVICE Professional August 2016- Present Invited member of the International Society if Thrombosis and Hemostasis(ISTH) Education Committee Invited member of the HTRS Publications committee August 2016- Present Invited Member of the Blood Products Advisory Committee (BPAC) of the FDA 2015-Present ModeratorChair of Scientific Session on Treatment of Acquired Hemostatic June 2015 Disorders at the International Society Of Thrombosis and Hemostasis (ISTH) Society Annual Meeting June 2015 Member of the Board of Directors for the Hemophilia and Thrombosis Apr 2015-Present Research Society (HTRS) Elected to the Board of Directors of the national research group for having developed nationally recognized expertise in hemostasis Member of the Medical and Scientific Advisory Committee (MASAC) of the 2014- Present National Hemophilia Foundation Invited member Nationally recognized for the development of national guidelines and recommendations for the management of patients with bleeding disorders
4 SERVICE Professional
Board member of the Intercontinental Cooperative ITP Study Group (ICIS) Manuscript writing and data collection by the International collaborative group
Member of The Women amp Girls with Blood Disorders (WGBD) Learning Action Network (LAN) for healthcare professionals Invited member Instrumental in the development of National Collaborative Research projects in Women and Girls with Bleeding disorders International Society of Thrombosis and Hemostasis ndash Co-chair of the FVIIIFIX subcommittee Working Party on Standardization of 2012-2014 Thromboelastography Developed the international recommendations for Standardization of Thromboelastography Chairman of the International TEG-ROTEM Working Group Instrumental in 2006-Present developing standardization and provided international guidance to methodology and validation Member of the Global Emerging HEmophilia Panel (GEHEP) Project leader and co-investigator for multiple projects with an International group of Researchers who actively conduct Research in Hemophilia and hemostasis
SERVICE Community
Presentation for lay audiences
Glanzmann Thrombasthenia 101 Invited by Comprehensive Health Education Services LLC a Not-for-profit company involved with providing health education to familiespatients to help patients and families of patients with Glanzmann Thrombasthenia obtain knowledge about the diagnosis
Von Willebrand Disease- Diagnosis and Treatment HFM Springfest
Von Willebrand Disease Treatment options- Midwest Regional VWD Conference
Treatment Options for Joint Disease in Hemophilia Presented at Hemophilia Foundation of Michigan-Springfest
Hemarthrosis in Hemophilia- Importance of prophylaxis in prevention of hemophilic arthropathy Presented at the Hemophilia Parent Support Group Meeting
Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI
Educational Outreach Thromboelastography- Interpretation and How to use data- 63rd and 64th Annual Detroit Trauma Symposum
VWD Regional Roundtable Case discussion with local Hemophilia Treatment Center and private hematologists on the management of patients with von Willebrand disease in the peri-operative or trauma setting at the Sheraton Detroit Metro Airport in Romulus Michigan
2014-Present
2014-Present
2009- Present
Nov 2016
April 2016
Nov 2015
May 2014
Aug 2012
May 2010
Nov 2015 2016
Apr2012
5 SERVICE Community
Heavy Bleeding- a sign of something more serious Your role in detecting Von Willebrand Disease Presentation on Von Willebrand Disease- clinical manifestations pathophysiology and management for local area primary Pediatricians OBGyn and ENT physicians Livonia MI
Educational Outreach Platelet disorders in children Overview of platelet disorders and testing for platelet dysfunction for local area general pediatricians CHM Stilson Center Clinton Township MI
The OBGYNrsquos Role in von Willebrand Disease (VWD) Detection Detroit MI (Presented to OBGyn physicians)
Media Presentations
Treatment Decisions and Clinical Outcomes in Hemophilia B with Inhibitors This educational initiative includes 1 CME vodcast and 1 Clinical Insight and is targeted to Hematologists Hemophilia Treatment Center(HTC) specialists HTC nurses and other clinicians interested in hemophilia treatment and management
ldquoVWD Collaborate to Educate Campaignrdquo launched in partnership with HealthyWomen Media Release and Outreach ndash Media release distributed to more than 12000
journalists Pitched story to 272 print online and broadcast journalists Radio Media Tour ndash Interview with Dr Chitlur and Beth Cahill targeted radio stations in the top 50 markets Matte Release ndash Distributed to more than 10000 news sources reaching VWD patients at the grassroots level Audio News Release ndash Two 60-second audio packages and two 30-second PSA scripts distributed to 12000+ local regional and national radio stations
Scholarly Service
Grant Review Committees
Reviewer of Research Grants for NHLBI- Clinical Trials Review committee- Ad Hoc Reviewer
Mentored Research Awards Abstract Review Committee-HemophiliaThrombosis Research Society (HTRS)
NationalInternational
Invited Member of the Blood Products Advisory Committee (BPAC) - FDA
Editorial Board Membership Haemophilia
Selected by peers to be included in the ldquoBest Doctors in Americardquo database Only 5 of physicians in the United States earn this recognition As part of this affiliation provides consultative services for patients
Jun 2011
Aug 2009
Jun 2009
Apr2012
2015
2013-Present
2015- Present
2014-current
2007-2008 2009-2013
6 Scholarly Service
Review of Manuscripts J of Biomaterials Science Polymer edition Pediatric Blood and Cancer Haemophilia (Editorial Board Member) Journal of Thrombosis Hemostasis Annals of Hematology Thrombosis Research Thrombosis and Haemostasis Pediatrics in Review J of the American Board of Family Medicine
OTHER SERVICE Member of the Steering committee for a multicenter trial on the Real
life use of Extended half life products in patients with hemophilia Baxter ITP Regional Advisory Board Novo Nordisk Translational Advisory Board Baxter Bleed Reduction Advisory Board Baxalta Optimizing Prophylaxis in hemophilia Advisory Board- Chair Baxalta Challenges in Inhibitor management ndash Co-Chair
TEACHING Teaching at Wayne State University
Medical students Year III students while primary attending on HemOnc inpatient unit (1shy2 mosyr)Year IV students on elective rotation in hematologyoncology clinic
ResidentsFellowsInpatientbedside teaching on daily basis while primary attending on 6 West (25-35 mosyr) and while on-call on weekends1-2 lecturesyear on basic coagulation studies and bleeding disordersActively collaborate with residents and students to encourage manuscript writing and clinical studies See pub 13 Case reports31323335 Review articles 39 and Book chapter 6
Faculty (eg CME)ECMO Anticoagulation- Invited seminar at the Joint ICUCV Surgeryconference at Childrens Hospital of Michigan
Thromboelastography- guide to use in anesthesiology Invited seminar atthe CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan
Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital ofMichigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI
Teaching at other institutionsFaculty (eg CME)
Title Laboratory Diagnosis and Therapeutic Monitoring in PediatricHemophilia Avoiding Pifalls Optimizing OutcomesCredits 15 CME Activity Type CME Activity Symposium at the Annual American Society of Pediatric HemaotologyOncology Meeting May 12 2016Description A comprehensive Review of the current issues and challenges related to laboratory assessment of Pedaitric Hemophiliaprovided by GYoung MD DAdcock MD and Meera Chitlur MD
Dec 2016
Aug 2014
Nov 2011
May 2016
7
Faculty (eg CME)Title Hemophilia- A Primer Credits 15 CME Activity Type Online CME ActivityDescription Comprehensive Review of diagnosis and management ofHemophilia by Madhvi Rajpurkar MD and Meera Chitlur MD
Title Differential Diagnosis in a Young Child With Excessive Bleeding Epistaxis and BruisingCredits 075 CME 06 CNE | Expires 62016 Activity Type Online CME ActivityDescription This case-focused learning activity brings together bleedingexperts Mortimer Poncz MD and Meera Chitlur MD to discuss the case of a child born of a non-consanguineous marriage with excessive post-traumatic bleeding and epistaxis
Title Cyberoundsreg Unexplained Bleeding in Hospitalized Patients Credits 10 AMA 10 ANCCActivity Type Online CME ActivityDescription Given the approximately 365 million hospital admissions inthe United States an unexplained bleeding scenario could very well beone that you are required to manage someday Would you know how to handle it Meera B Chitlur- faculty presenter
Title Hemophilia Today What Clinicians Really Want to Knowrdquo Credits 15 CME 15 CNEActivity Type Online CME ActivityDescription This educational activity features three renowned experts inthe field of bleeding disorders Victor S Blanchette MD Meera B Chitlur MD and Steven W Pipe MD address some common gaps inknowledge by providing professional opinion on current and emergingtherapies and clinical challenges associated with managing patients withhemophilia
Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker Cincinnati ChildrenrsquosHospital and Medical center
Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio
Title Current Strategies for the Surgical Management of Patients With Congenital Bleeding DisordersCredits Not for credit Activity Type Online CME ActivityActivity Description Symposium held in conjunction with the 2011 ASPHO (American Society of Pediatric HematologyOncology) AnnualMeeting Victor S Blanchette MD FRCP Steven W Pipe MD and Meera B Chitlur MD Issues pertaining to the perioperative management of patients with congenital bleeding disorders As part oftheir discussion these noted experts address hemophilic and nonshyhemophilic inhibitors of coagulation standard and emerging coagulation tests and novel and experimental clotting factors
Jul 2015
Jul 2015
Nov 2013
Oct 2012
Oct 2012
Dec 2012
May 2011
8
Faculty (eg CME) Apr 2011 Title Treatment Decisions and Clinical Outcomes in Hemophilia B Patients With Inhibitors Credits 075 CME 10 CNE Activity Type Online CME Activity Activity Description In this vodcast learning activity Meera Chitlur MD explains the history prevalence of FIX deficiency and various treatment modalities available She also explores the possible causes for the co-manifestation of inhibitor development and allergic reactions and the usefulness of registries in monitoring the occurrence of inhibitors in patients with hemophilia B
Aug 2010 Global Assays in Hemostasis Invited speaker for Grand Rounds atDevaraj Urs Medical College Kolar Karnataka India
Aug 2009 Title FIX Deficiency and Inhibitors Report From the ISTH-SSC International Registry Credits 075 CME 10 CNE Activity Type Online CME ActivityActivity Description The advent of registry databases to aid collection ofinformation on hemophilia B has helped further the understanding of FIXdeficiency and inhibitors within the scientific community In this learningactivity Meera Chitlur MD discusses the importance of the ISTH-SSCInternational FIX Inhibitor Registry in addition to etiology of severe reactions associated with appearance of inhibitors in hemophilia B
Mentorship 2008DrShilpa Jain MD Mentored research project entitled ldquoThrombin generationin children with moderate to severe hemophiliardquo with year III Pediatric Resident Dr S Jain who was awarded first place in the Resident Research Competition 2009DrBMehta PGY2 mentor for research project on thrombin generation inpatients on Ventricular Assist Devicersquos 2009 2009-2011 Dr S Veluswamy Mentor to PGY3 resident 2012-2014 DrAbdullah Mentor to PGY2 resident 2012-2013 DrsAyesha Zia MD Fellow Mentor for fellow projects 2010-2013 DrLRao MD Fellow Clinical and Research Mentor 2013-2015 DrTSarkar Fellow Research mentor 2005Visiting professorscientists DrDSosothikul from Thailand 2007-2008
DrAlphan Kupesiz from Turkey May 2013 DrMaissaa Janbain MD Tulane University Externship mentor April 2013 Dr Indrayas Woldie MD Karmanos Cancer Institute WSU May2015 DrJing Christine Ye MD Karmanos Cancer Institute WSU July 2015 Dr Yasmina Abajas University of North Carolina Global Assays Training 2016-2017 Dr Katherine Regling PGY2-3 2016-2018 DrBettina Joi Isaac Fellow Research mentor 2016-2018 DrSarah Ramiz Fellow Research mentor
GRANTS CONTRACTS AND OTHER FUNDING
Active Grants and Contracts Role Site Principal Investigator Title Cascade Hemophilia Consortium Grant Sponsor Cascade Hemophilia Consortium
9 Trial StartEnc Date 6115-53116 (renewed yearly) Funding $221161
Active Grants and Contracts Role Site Principal Investigator Title My Life Our Future (MLOF2) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Period of Support 1115-123115 Funding Direct cost $1468 Indirect cost $38
Role Site Principal Investigator Title Validation of the ISTH-BAT (International Society on Thrombosis and Haemostasis Bleeding Assessment Tool) in Hemophilia Carriers Sponsor Queenrsquos University Grant StartEnd Date 32014-12016 Funding Direct cost $5750 Indirect cost $910
Role Site Principal Investigator Title Maternal and Child Health Bureau (MCHB) Comprehensive Care Sponsor Maternal and Child Health Bureau Grant StartEnd date 2014-2015 (renewed yearly) Funding $35000
Role Site Principal Investigator Title My Life Our Future (MLOF) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Trial StartEnc Date 12914-12816 Funding Direct cost $2748 Indirect cost $752
Role Co Investigator Title Hemophilia Inhibitor Research Study Ph III (HIRS) Site PI MRajpurkar MD Source Center for Disease Control Period of Support 1092014 ndash 9302015 Direct costs $20340 (based on enrollment)
Role Site Principal Investigator Title Hemophilia Foundation of MI Sponsor ATHN Trial StartEnc Date 9302014-92915 (renewed yearly) Funding $37000
Role Co Investigator Title Molecular and clinical biology of von Willebrandrsquos Disease (Zimmerman project) Source National Institutes of Science (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of Support 20114-013117 Direct Cost $16413 (Based on enrollment)
10
Active Grants and Contracts
Role Co Investigator Title Comparative Effectiveness in the Diagnosis of vWD Source National Institutes of Health (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of support 2114-13117 Direct Cost $33534 (Based on enrollment)
Role Co-Investigator Title Multicenter Evaluation of the Duration of Therapy for Thrombosis in Children Site PI MRajpurkar Source All Childrens Research Institute Inc Period of Support 01012014-12312018 Direct cost $9230
Role Site Principal Investigator Title Personalized Medicine in Hemophilia Sponsor Childrens Hospital of Los Angeles Trial StartEnc Date 7113-63016 Funding Direct cost $33041 Indirect cost $17181
Role Principal Investigator Title Regional and Cultural Variance in Perceptions Pertaining to Research Participation Sponsor None Trial StartEnd Date 0513-122015 Funding NA
Role Principal Investigator Percent Effort 20 Title Thromboelastography in Severe Hemophilia Following Clotting Factor Replacement Therapy The primary objective is to evaluate the utility of Thromboelastography in the assessment of pharmacokinetics after factor replacement in patients with severemoderately severe hemophilia Sponsor Childrens Research Center of Michigan Grant StartEnd Date 22008- 122015 (closed to enrollment Data analysis ongoing) Funding Direct cost $45910 Indirect cost 1069342
Role Site PI Title Pediatric and adult intercontinental registry on chronic ITP Sponsor University Childrenrsquos Hospital Basel Switzerland Trial StartEnd Date 404 to 62016 80 patients entered to date from our Center Funding NA
Role Co- Investigator Title A Randomized Open-Label Active Controlled Safety and Extrapolated Efficacy Study in Pediatric Subjects Requiring Anticoagulation for the Treatment of a Venous Thromboembolic Event Source Pfizer Inc
11 Period of support 612015- 5312020 Total Direct Cost $63802 (based on enrollment)
Clinical Trials Activities Role Site Principal Investigator Title Use of rFXIII in treatment of congenital FXIII deficiency a prospective multi-centre observational study- MENTOR 6 (25RGV) Sponsor Novo Nordisk Trial StartEnd Date 11515-11417 Funding $25611
Role Site Principal Investigator Title Study of Prophylaxis ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated with ADVATE or RIXUBIS (SPACE) (25RE7) Sponsor Baxter Healthcare Corp Trial startEnd Date 12914-12816 Funding Direct cost $9541 Indirect cost $2481 (based on patient enrollment)
Role Co Investigator Title Oral Rivaroxaban in children with venous thrombosis a 30 day open label active controlled randomized study of the safety efficacy and the pharmacokinetic and pharmacodynamic properties of oral rivaroxaban in children with venous thrombosis Source Bayer Corporation Period of support 062314- 04082016 Total Direct Cost 74352
Role Co Investigator Title An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune (Idiopathic) Thrombocytopenia Purpura (ITP) Site PI MCallaghan Sponsor Amgen Inc Trial StartEnd Date 032213 - 32118 Funding $130870
Role Site Principal- Investigator Title PH3 NN7088-3859 A Multi-National Trial Evaluating Safety and Efficacy Including Pharmacokinetics of NNC 0159-0000-1003 when Administered for Treatment and Prophylaxis of Bleeding in Patients with Haemophilia A - Pathfinder N8 GP (25QPY) Sponsor Novo Nordisk Trial startEnd Date 11813- 102121 Funding Direct cost $61538 Indirect cost $16000
Role Co- Primary Investigator Title Safety and Efficacy of NNC 0155-0000-0004 in Prevention and Treatment of Bleeds in Pediatric Previously Untreated Patients with Haemophilia A (Guardian) N8 PUPs Source Novo Nordisk Period of support 091212- 04082016 Total Cost $15270 (based on enrollment)
12
Clinical Trials Activities Role Co-Investigator Title Rescue Immune-tolerance Study in ITI Experienced Patients shyResist Experienced Source City of Hope Period of support 08152012-02122015 (Study is closed to accrual but following subjects enrolled) Direct Cost$ 5750
Role Co Investigator Title Single-dose pilot study of rivaroxaban in pediatric subjects with venous thromboembolism-12892 Source Bayer Corporation Site PI MRajpurkar Period of Support 061512-123115 Total Direct Cost $83961 (based on enrollment)
Role Co-investigator Title A Phase 3 Randomized Double Blind Placebo Controlled Study to Determine the Safety and Efficacy of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune Thrombocytopenia (ITP) Principal Investigator M Callaghan Sponsor Amgen Inc Trial StartEnd Date 1211-0414 Funding $56000
Role Co Investigator Title - A Three Month Prospective Open Label Study of Therapy with FRAGMINreg (Dalteparin Sodium Injection) in Children with Malignancies and Venous Thromboembolism - FRAG-A001-201 Source Easai Inc Site PI MRajpurkar Period of Support 092810 - 052115 Total Direct Cost$5285742
Role Site Principal Investigator Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (25PYE) Sponsor Novo Nordisk Inc Trial startEnd Date 22309-122115 Funding Direct cost $44005 Indirect cost $11441
Completed Studies
Role Site Principal Investigator Title Evaluate the Activity a Site Specific of BDomain Deleted (BDD) Pegylated Recombinant FVIII Protein (BAY 94-9027) in Plasma Samples Measured with both Chromogenic and One Stage Assays Sponsor Bayer Trial StartEnc Date 8115- 8116 Funding $696400
13 Completed Studies
Role Co-investigator Title Safety and Efficacy of N8 in prevention and treatment of bleeds in pediatric Previously treated patients with Hemophilia A Site PI MRajpurkar Sponsor Novo Nordisk Trial StartEnd Date 1210 to 911 Funding $381729
Role Site PI Title 3760- Phase 3b Trial Investigating the Pharmacokinetics amp Safety Profile of Single IV Dose of rFXIII in Paediatric (1 to less than 6 Years Old) Subjects with Congenital FXIII A-Subunit Deficiency Sponsor Novo Nordisk Inc Trial StartEnd Date 1110-0112 Funding $ 4315752
Role Co-investigator Title Universal data and serum specimen collection (UDC) system for hemophilia Sponsor Centers for Disease Control (CDC) Site PI JLusher Trial StartEnd Date 0610 to 511 Funding $48000
Role Site PI for multi center trial Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (N13 3720) (Mentor 2) Sponsor Novo Nordisk Inc Trial StartEnd Date 0410- 1214 Funding $ 5544504
Role Principal Investigator Title Prospective ADVATE ITI Registry (Pair) Sponsor Baxter Trial StartEnd Date 210 -411 Funding $2000
Role Co-investigator Title Mechanisms of Race Based Differences in Factor VIII Immunogenicity in Hemophilia Sponsor NIH Supleveda Site PI JLusher Trial StartEnd Date 0909 to 0911 Funding $70000
Role Co-investigator Title Treatment of Congenital Factor VII deficiency A prospective observational studySTER [Seven Deficiency Treatment Registry] Site PI MRajpurkar Sponsor Quintiles Inc Trial StartEnd Date 709 to 1210 Funding $2800
14 Completed Studies
Role Site PI for multi center trial Title Prophylaxis Patient Case Collection (PRO-PACT) Sponsor Novo Nordisk Inc Trial StartEnd Date 409-0510 Funding $3984
Role Co-investigator Title Phase 1 Prospective Randomized Crossover Study to Compare the Pharmacokinetics and Safety of rAHF-PFM Reconstituted in 2mL versus 5mL SWFI in Previously Treated Severe Hemophilia A Patients Site PI JLusher Sponsor Baxter BioScience Trial StartEnd Date 208- 310 Funding $34272
Role Consultant Title Thromboelastographic evaluation of hypercoagulability after Fontanrsquos surgery Site PI MRajpurkar Sponsor CRCM Trial StartEnd Date 706 to 1210 Funding $ 32507
Role Site PI Title Recombinant anti-hemophilic factor manufactured and formulated without added human or animal proteins (rAHF PFM) evaluation of immunogenicity efficacy and safety in previously untreated patients with hemophilia A (PUP study) Sponsor Baxter Bioscience Trial StartEnd Date 404-0909 Funding $32582
Role Co-investigator Title Chiron Gene Therapy Long Term Safety Follow-up Site PI JLusher Sponsor Chiron Corp Trial StartEnd Date 0800 to 1210 Funding $1771
PUBLICATIONS Peer-Reviewed Publications
Reports of Original Work Notes Trainee or student mentored by MC Citation data from Web of Science
1 Iorio A Keepanasseril A Foster G Navarro-Ruan T McEneny-King A Edginton AN Thabane L WAPPS-Hemo co-investigator network Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Study Protocol JMIR Res Protoc 2016 Dec 155(4)e239
2 James PD Mahlangu J Bidlingmaier C Mingot-Castellano ME Chitlur M Fogarty PF Cuker A Mancuso ME Holme PA Grabell J Satkunam N Hopman WM Mathew P Global Emerging HEmostasis Experts Panel (GEHEP) Evaluation of the utility of the ISTH-BAT in haemophilia carriers a multinational studyHaemophilia 2016 Nov22(6)912-918
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
4 SERVICE Professional
Board member of the Intercontinental Cooperative ITP Study Group (ICIS) Manuscript writing and data collection by the International collaborative group
Member of The Women amp Girls with Blood Disorders (WGBD) Learning Action Network (LAN) for healthcare professionals Invited member Instrumental in the development of National Collaborative Research projects in Women and Girls with Bleeding disorders International Society of Thrombosis and Hemostasis ndash Co-chair of the FVIIIFIX subcommittee Working Party on Standardization of 2012-2014 Thromboelastography Developed the international recommendations for Standardization of Thromboelastography Chairman of the International TEG-ROTEM Working Group Instrumental in 2006-Present developing standardization and provided international guidance to methodology and validation Member of the Global Emerging HEmophilia Panel (GEHEP) Project leader and co-investigator for multiple projects with an International group of Researchers who actively conduct Research in Hemophilia and hemostasis
SERVICE Community
Presentation for lay audiences
Glanzmann Thrombasthenia 101 Invited by Comprehensive Health Education Services LLC a Not-for-profit company involved with providing health education to familiespatients to help patients and families of patients with Glanzmann Thrombasthenia obtain knowledge about the diagnosis
Von Willebrand Disease- Diagnosis and Treatment HFM Springfest
Von Willebrand Disease Treatment options- Midwest Regional VWD Conference
Treatment Options for Joint Disease in Hemophilia Presented at Hemophilia Foundation of Michigan-Springfest
Hemarthrosis in Hemophilia- Importance of prophylaxis in prevention of hemophilic arthropathy Presented at the Hemophilia Parent Support Group Meeting
Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI
Educational Outreach Thromboelastography- Interpretation and How to use data- 63rd and 64th Annual Detroit Trauma Symposum
VWD Regional Roundtable Case discussion with local Hemophilia Treatment Center and private hematologists on the management of patients with von Willebrand disease in the peri-operative or trauma setting at the Sheraton Detroit Metro Airport in Romulus Michigan
2014-Present
2014-Present
2009- Present
Nov 2016
April 2016
Nov 2015
May 2014
Aug 2012
May 2010
Nov 2015 2016
Apr2012
5 SERVICE Community
Heavy Bleeding- a sign of something more serious Your role in detecting Von Willebrand Disease Presentation on Von Willebrand Disease- clinical manifestations pathophysiology and management for local area primary Pediatricians OBGyn and ENT physicians Livonia MI
Educational Outreach Platelet disorders in children Overview of platelet disorders and testing for platelet dysfunction for local area general pediatricians CHM Stilson Center Clinton Township MI
The OBGYNrsquos Role in von Willebrand Disease (VWD) Detection Detroit MI (Presented to OBGyn physicians)
Media Presentations
Treatment Decisions and Clinical Outcomes in Hemophilia B with Inhibitors This educational initiative includes 1 CME vodcast and 1 Clinical Insight and is targeted to Hematologists Hemophilia Treatment Center(HTC) specialists HTC nurses and other clinicians interested in hemophilia treatment and management
ldquoVWD Collaborate to Educate Campaignrdquo launched in partnership with HealthyWomen Media Release and Outreach ndash Media release distributed to more than 12000
journalists Pitched story to 272 print online and broadcast journalists Radio Media Tour ndash Interview with Dr Chitlur and Beth Cahill targeted radio stations in the top 50 markets Matte Release ndash Distributed to more than 10000 news sources reaching VWD patients at the grassroots level Audio News Release ndash Two 60-second audio packages and two 30-second PSA scripts distributed to 12000+ local regional and national radio stations
Scholarly Service
Grant Review Committees
Reviewer of Research Grants for NHLBI- Clinical Trials Review committee- Ad Hoc Reviewer
Mentored Research Awards Abstract Review Committee-HemophiliaThrombosis Research Society (HTRS)
NationalInternational
Invited Member of the Blood Products Advisory Committee (BPAC) - FDA
Editorial Board Membership Haemophilia
Selected by peers to be included in the ldquoBest Doctors in Americardquo database Only 5 of physicians in the United States earn this recognition As part of this affiliation provides consultative services for patients
Jun 2011
Aug 2009
Jun 2009
Apr2012
2015
2013-Present
2015- Present
2014-current
2007-2008 2009-2013
6 Scholarly Service
Review of Manuscripts J of Biomaterials Science Polymer edition Pediatric Blood and Cancer Haemophilia (Editorial Board Member) Journal of Thrombosis Hemostasis Annals of Hematology Thrombosis Research Thrombosis and Haemostasis Pediatrics in Review J of the American Board of Family Medicine
OTHER SERVICE Member of the Steering committee for a multicenter trial on the Real
life use of Extended half life products in patients with hemophilia Baxter ITP Regional Advisory Board Novo Nordisk Translational Advisory Board Baxter Bleed Reduction Advisory Board Baxalta Optimizing Prophylaxis in hemophilia Advisory Board- Chair Baxalta Challenges in Inhibitor management ndash Co-Chair
TEACHING Teaching at Wayne State University
Medical students Year III students while primary attending on HemOnc inpatient unit (1shy2 mosyr)Year IV students on elective rotation in hematologyoncology clinic
ResidentsFellowsInpatientbedside teaching on daily basis while primary attending on 6 West (25-35 mosyr) and while on-call on weekends1-2 lecturesyear on basic coagulation studies and bleeding disordersActively collaborate with residents and students to encourage manuscript writing and clinical studies See pub 13 Case reports31323335 Review articles 39 and Book chapter 6
Faculty (eg CME)ECMO Anticoagulation- Invited seminar at the Joint ICUCV Surgeryconference at Childrens Hospital of Michigan
Thromboelastography- guide to use in anesthesiology Invited seminar atthe CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan
Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital ofMichigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI
Teaching at other institutionsFaculty (eg CME)
Title Laboratory Diagnosis and Therapeutic Monitoring in PediatricHemophilia Avoiding Pifalls Optimizing OutcomesCredits 15 CME Activity Type CME Activity Symposium at the Annual American Society of Pediatric HemaotologyOncology Meeting May 12 2016Description A comprehensive Review of the current issues and challenges related to laboratory assessment of Pedaitric Hemophiliaprovided by GYoung MD DAdcock MD and Meera Chitlur MD
Dec 2016
Aug 2014
Nov 2011
May 2016
7
Faculty (eg CME)Title Hemophilia- A Primer Credits 15 CME Activity Type Online CME ActivityDescription Comprehensive Review of diagnosis and management ofHemophilia by Madhvi Rajpurkar MD and Meera Chitlur MD
Title Differential Diagnosis in a Young Child With Excessive Bleeding Epistaxis and BruisingCredits 075 CME 06 CNE | Expires 62016 Activity Type Online CME ActivityDescription This case-focused learning activity brings together bleedingexperts Mortimer Poncz MD and Meera Chitlur MD to discuss the case of a child born of a non-consanguineous marriage with excessive post-traumatic bleeding and epistaxis
Title Cyberoundsreg Unexplained Bleeding in Hospitalized Patients Credits 10 AMA 10 ANCCActivity Type Online CME ActivityDescription Given the approximately 365 million hospital admissions inthe United States an unexplained bleeding scenario could very well beone that you are required to manage someday Would you know how to handle it Meera B Chitlur- faculty presenter
Title Hemophilia Today What Clinicians Really Want to Knowrdquo Credits 15 CME 15 CNEActivity Type Online CME ActivityDescription This educational activity features three renowned experts inthe field of bleeding disorders Victor S Blanchette MD Meera B Chitlur MD and Steven W Pipe MD address some common gaps inknowledge by providing professional opinion on current and emergingtherapies and clinical challenges associated with managing patients withhemophilia
Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker Cincinnati ChildrenrsquosHospital and Medical center
Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio
Title Current Strategies for the Surgical Management of Patients With Congenital Bleeding DisordersCredits Not for credit Activity Type Online CME ActivityActivity Description Symposium held in conjunction with the 2011 ASPHO (American Society of Pediatric HematologyOncology) AnnualMeeting Victor S Blanchette MD FRCP Steven W Pipe MD and Meera B Chitlur MD Issues pertaining to the perioperative management of patients with congenital bleeding disorders As part oftheir discussion these noted experts address hemophilic and nonshyhemophilic inhibitors of coagulation standard and emerging coagulation tests and novel and experimental clotting factors
Jul 2015
Jul 2015
Nov 2013
Oct 2012
Oct 2012
Dec 2012
May 2011
8
Faculty (eg CME) Apr 2011 Title Treatment Decisions and Clinical Outcomes in Hemophilia B Patients With Inhibitors Credits 075 CME 10 CNE Activity Type Online CME Activity Activity Description In this vodcast learning activity Meera Chitlur MD explains the history prevalence of FIX deficiency and various treatment modalities available She also explores the possible causes for the co-manifestation of inhibitor development and allergic reactions and the usefulness of registries in monitoring the occurrence of inhibitors in patients with hemophilia B
Aug 2010 Global Assays in Hemostasis Invited speaker for Grand Rounds atDevaraj Urs Medical College Kolar Karnataka India
Aug 2009 Title FIX Deficiency and Inhibitors Report From the ISTH-SSC International Registry Credits 075 CME 10 CNE Activity Type Online CME ActivityActivity Description The advent of registry databases to aid collection ofinformation on hemophilia B has helped further the understanding of FIXdeficiency and inhibitors within the scientific community In this learningactivity Meera Chitlur MD discusses the importance of the ISTH-SSCInternational FIX Inhibitor Registry in addition to etiology of severe reactions associated with appearance of inhibitors in hemophilia B
Mentorship 2008DrShilpa Jain MD Mentored research project entitled ldquoThrombin generationin children with moderate to severe hemophiliardquo with year III Pediatric Resident Dr S Jain who was awarded first place in the Resident Research Competition 2009DrBMehta PGY2 mentor for research project on thrombin generation inpatients on Ventricular Assist Devicersquos 2009 2009-2011 Dr S Veluswamy Mentor to PGY3 resident 2012-2014 DrAbdullah Mentor to PGY2 resident 2012-2013 DrsAyesha Zia MD Fellow Mentor for fellow projects 2010-2013 DrLRao MD Fellow Clinical and Research Mentor 2013-2015 DrTSarkar Fellow Research mentor 2005Visiting professorscientists DrDSosothikul from Thailand 2007-2008
DrAlphan Kupesiz from Turkey May 2013 DrMaissaa Janbain MD Tulane University Externship mentor April 2013 Dr Indrayas Woldie MD Karmanos Cancer Institute WSU May2015 DrJing Christine Ye MD Karmanos Cancer Institute WSU July 2015 Dr Yasmina Abajas University of North Carolina Global Assays Training 2016-2017 Dr Katherine Regling PGY2-3 2016-2018 DrBettina Joi Isaac Fellow Research mentor 2016-2018 DrSarah Ramiz Fellow Research mentor
GRANTS CONTRACTS AND OTHER FUNDING
Active Grants and Contracts Role Site Principal Investigator Title Cascade Hemophilia Consortium Grant Sponsor Cascade Hemophilia Consortium
9 Trial StartEnc Date 6115-53116 (renewed yearly) Funding $221161
Active Grants and Contracts Role Site Principal Investigator Title My Life Our Future (MLOF2) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Period of Support 1115-123115 Funding Direct cost $1468 Indirect cost $38
Role Site Principal Investigator Title Validation of the ISTH-BAT (International Society on Thrombosis and Haemostasis Bleeding Assessment Tool) in Hemophilia Carriers Sponsor Queenrsquos University Grant StartEnd Date 32014-12016 Funding Direct cost $5750 Indirect cost $910
Role Site Principal Investigator Title Maternal and Child Health Bureau (MCHB) Comprehensive Care Sponsor Maternal and Child Health Bureau Grant StartEnd date 2014-2015 (renewed yearly) Funding $35000
Role Site Principal Investigator Title My Life Our Future (MLOF) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Trial StartEnc Date 12914-12816 Funding Direct cost $2748 Indirect cost $752
Role Co Investigator Title Hemophilia Inhibitor Research Study Ph III (HIRS) Site PI MRajpurkar MD Source Center for Disease Control Period of Support 1092014 ndash 9302015 Direct costs $20340 (based on enrollment)
Role Site Principal Investigator Title Hemophilia Foundation of MI Sponsor ATHN Trial StartEnc Date 9302014-92915 (renewed yearly) Funding $37000
Role Co Investigator Title Molecular and clinical biology of von Willebrandrsquos Disease (Zimmerman project) Source National Institutes of Science (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of Support 20114-013117 Direct Cost $16413 (Based on enrollment)
10
Active Grants and Contracts
Role Co Investigator Title Comparative Effectiveness in the Diagnosis of vWD Source National Institutes of Health (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of support 2114-13117 Direct Cost $33534 (Based on enrollment)
Role Co-Investigator Title Multicenter Evaluation of the Duration of Therapy for Thrombosis in Children Site PI MRajpurkar Source All Childrens Research Institute Inc Period of Support 01012014-12312018 Direct cost $9230
Role Site Principal Investigator Title Personalized Medicine in Hemophilia Sponsor Childrens Hospital of Los Angeles Trial StartEnc Date 7113-63016 Funding Direct cost $33041 Indirect cost $17181
Role Principal Investigator Title Regional and Cultural Variance in Perceptions Pertaining to Research Participation Sponsor None Trial StartEnd Date 0513-122015 Funding NA
Role Principal Investigator Percent Effort 20 Title Thromboelastography in Severe Hemophilia Following Clotting Factor Replacement Therapy The primary objective is to evaluate the utility of Thromboelastography in the assessment of pharmacokinetics after factor replacement in patients with severemoderately severe hemophilia Sponsor Childrens Research Center of Michigan Grant StartEnd Date 22008- 122015 (closed to enrollment Data analysis ongoing) Funding Direct cost $45910 Indirect cost 1069342
Role Site PI Title Pediatric and adult intercontinental registry on chronic ITP Sponsor University Childrenrsquos Hospital Basel Switzerland Trial StartEnd Date 404 to 62016 80 patients entered to date from our Center Funding NA
Role Co- Investigator Title A Randomized Open-Label Active Controlled Safety and Extrapolated Efficacy Study in Pediatric Subjects Requiring Anticoagulation for the Treatment of a Venous Thromboembolic Event Source Pfizer Inc
11 Period of support 612015- 5312020 Total Direct Cost $63802 (based on enrollment)
Clinical Trials Activities Role Site Principal Investigator Title Use of rFXIII in treatment of congenital FXIII deficiency a prospective multi-centre observational study- MENTOR 6 (25RGV) Sponsor Novo Nordisk Trial StartEnd Date 11515-11417 Funding $25611
Role Site Principal Investigator Title Study of Prophylaxis ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated with ADVATE or RIXUBIS (SPACE) (25RE7) Sponsor Baxter Healthcare Corp Trial startEnd Date 12914-12816 Funding Direct cost $9541 Indirect cost $2481 (based on patient enrollment)
Role Co Investigator Title Oral Rivaroxaban in children with venous thrombosis a 30 day open label active controlled randomized study of the safety efficacy and the pharmacokinetic and pharmacodynamic properties of oral rivaroxaban in children with venous thrombosis Source Bayer Corporation Period of support 062314- 04082016 Total Direct Cost 74352
Role Co Investigator Title An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune (Idiopathic) Thrombocytopenia Purpura (ITP) Site PI MCallaghan Sponsor Amgen Inc Trial StartEnd Date 032213 - 32118 Funding $130870
Role Site Principal- Investigator Title PH3 NN7088-3859 A Multi-National Trial Evaluating Safety and Efficacy Including Pharmacokinetics of NNC 0159-0000-1003 when Administered for Treatment and Prophylaxis of Bleeding in Patients with Haemophilia A - Pathfinder N8 GP (25QPY) Sponsor Novo Nordisk Trial startEnd Date 11813- 102121 Funding Direct cost $61538 Indirect cost $16000
Role Co- Primary Investigator Title Safety and Efficacy of NNC 0155-0000-0004 in Prevention and Treatment of Bleeds in Pediatric Previously Untreated Patients with Haemophilia A (Guardian) N8 PUPs Source Novo Nordisk Period of support 091212- 04082016 Total Cost $15270 (based on enrollment)
12
Clinical Trials Activities Role Co-Investigator Title Rescue Immune-tolerance Study in ITI Experienced Patients shyResist Experienced Source City of Hope Period of support 08152012-02122015 (Study is closed to accrual but following subjects enrolled) Direct Cost$ 5750
Role Co Investigator Title Single-dose pilot study of rivaroxaban in pediatric subjects with venous thromboembolism-12892 Source Bayer Corporation Site PI MRajpurkar Period of Support 061512-123115 Total Direct Cost $83961 (based on enrollment)
Role Co-investigator Title A Phase 3 Randomized Double Blind Placebo Controlled Study to Determine the Safety and Efficacy of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune Thrombocytopenia (ITP) Principal Investigator M Callaghan Sponsor Amgen Inc Trial StartEnd Date 1211-0414 Funding $56000
Role Co Investigator Title - A Three Month Prospective Open Label Study of Therapy with FRAGMINreg (Dalteparin Sodium Injection) in Children with Malignancies and Venous Thromboembolism - FRAG-A001-201 Source Easai Inc Site PI MRajpurkar Period of Support 092810 - 052115 Total Direct Cost$5285742
Role Site Principal Investigator Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (25PYE) Sponsor Novo Nordisk Inc Trial startEnd Date 22309-122115 Funding Direct cost $44005 Indirect cost $11441
Completed Studies
Role Site Principal Investigator Title Evaluate the Activity a Site Specific of BDomain Deleted (BDD) Pegylated Recombinant FVIII Protein (BAY 94-9027) in Plasma Samples Measured with both Chromogenic and One Stage Assays Sponsor Bayer Trial StartEnc Date 8115- 8116 Funding $696400
13 Completed Studies
Role Co-investigator Title Safety and Efficacy of N8 in prevention and treatment of bleeds in pediatric Previously treated patients with Hemophilia A Site PI MRajpurkar Sponsor Novo Nordisk Trial StartEnd Date 1210 to 911 Funding $381729
Role Site PI Title 3760- Phase 3b Trial Investigating the Pharmacokinetics amp Safety Profile of Single IV Dose of rFXIII in Paediatric (1 to less than 6 Years Old) Subjects with Congenital FXIII A-Subunit Deficiency Sponsor Novo Nordisk Inc Trial StartEnd Date 1110-0112 Funding $ 4315752
Role Co-investigator Title Universal data and serum specimen collection (UDC) system for hemophilia Sponsor Centers for Disease Control (CDC) Site PI JLusher Trial StartEnd Date 0610 to 511 Funding $48000
Role Site PI for multi center trial Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (N13 3720) (Mentor 2) Sponsor Novo Nordisk Inc Trial StartEnd Date 0410- 1214 Funding $ 5544504
Role Principal Investigator Title Prospective ADVATE ITI Registry (Pair) Sponsor Baxter Trial StartEnd Date 210 -411 Funding $2000
Role Co-investigator Title Mechanisms of Race Based Differences in Factor VIII Immunogenicity in Hemophilia Sponsor NIH Supleveda Site PI JLusher Trial StartEnd Date 0909 to 0911 Funding $70000
Role Co-investigator Title Treatment of Congenital Factor VII deficiency A prospective observational studySTER [Seven Deficiency Treatment Registry] Site PI MRajpurkar Sponsor Quintiles Inc Trial StartEnd Date 709 to 1210 Funding $2800
14 Completed Studies
Role Site PI for multi center trial Title Prophylaxis Patient Case Collection (PRO-PACT) Sponsor Novo Nordisk Inc Trial StartEnd Date 409-0510 Funding $3984
Role Co-investigator Title Phase 1 Prospective Randomized Crossover Study to Compare the Pharmacokinetics and Safety of rAHF-PFM Reconstituted in 2mL versus 5mL SWFI in Previously Treated Severe Hemophilia A Patients Site PI JLusher Sponsor Baxter BioScience Trial StartEnd Date 208- 310 Funding $34272
Role Consultant Title Thromboelastographic evaluation of hypercoagulability after Fontanrsquos surgery Site PI MRajpurkar Sponsor CRCM Trial StartEnd Date 706 to 1210 Funding $ 32507
Role Site PI Title Recombinant anti-hemophilic factor manufactured and formulated without added human or animal proteins (rAHF PFM) evaluation of immunogenicity efficacy and safety in previously untreated patients with hemophilia A (PUP study) Sponsor Baxter Bioscience Trial StartEnd Date 404-0909 Funding $32582
Role Co-investigator Title Chiron Gene Therapy Long Term Safety Follow-up Site PI JLusher Sponsor Chiron Corp Trial StartEnd Date 0800 to 1210 Funding $1771
PUBLICATIONS Peer-Reviewed Publications
Reports of Original Work Notes Trainee or student mentored by MC Citation data from Web of Science
1 Iorio A Keepanasseril A Foster G Navarro-Ruan T McEneny-King A Edginton AN Thabane L WAPPS-Hemo co-investigator network Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Study Protocol JMIR Res Protoc 2016 Dec 155(4)e239
2 James PD Mahlangu J Bidlingmaier C Mingot-Castellano ME Chitlur M Fogarty PF Cuker A Mancuso ME Holme PA Grabell J Satkunam N Hopman WM Mathew P Global Emerging HEmostasis Experts Panel (GEHEP) Evaluation of the utility of the ISTH-BAT in haemophilia carriers a multinational studyHaemophilia 2016 Nov22(6)912-918
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
5 SERVICE Community
Heavy Bleeding- a sign of something more serious Your role in detecting Von Willebrand Disease Presentation on Von Willebrand Disease- clinical manifestations pathophysiology and management for local area primary Pediatricians OBGyn and ENT physicians Livonia MI
Educational Outreach Platelet disorders in children Overview of platelet disorders and testing for platelet dysfunction for local area general pediatricians CHM Stilson Center Clinton Township MI
The OBGYNrsquos Role in von Willebrand Disease (VWD) Detection Detroit MI (Presented to OBGyn physicians)
Media Presentations
Treatment Decisions and Clinical Outcomes in Hemophilia B with Inhibitors This educational initiative includes 1 CME vodcast and 1 Clinical Insight and is targeted to Hematologists Hemophilia Treatment Center(HTC) specialists HTC nurses and other clinicians interested in hemophilia treatment and management
ldquoVWD Collaborate to Educate Campaignrdquo launched in partnership with HealthyWomen Media Release and Outreach ndash Media release distributed to more than 12000
journalists Pitched story to 272 print online and broadcast journalists Radio Media Tour ndash Interview with Dr Chitlur and Beth Cahill targeted radio stations in the top 50 markets Matte Release ndash Distributed to more than 10000 news sources reaching VWD patients at the grassroots level Audio News Release ndash Two 60-second audio packages and two 30-second PSA scripts distributed to 12000+ local regional and national radio stations
Scholarly Service
Grant Review Committees
Reviewer of Research Grants for NHLBI- Clinical Trials Review committee- Ad Hoc Reviewer
Mentored Research Awards Abstract Review Committee-HemophiliaThrombosis Research Society (HTRS)
NationalInternational
Invited Member of the Blood Products Advisory Committee (BPAC) - FDA
Editorial Board Membership Haemophilia
Selected by peers to be included in the ldquoBest Doctors in Americardquo database Only 5 of physicians in the United States earn this recognition As part of this affiliation provides consultative services for patients
Jun 2011
Aug 2009
Jun 2009
Apr2012
2015
2013-Present
2015- Present
2014-current
2007-2008 2009-2013
6 Scholarly Service
Review of Manuscripts J of Biomaterials Science Polymer edition Pediatric Blood and Cancer Haemophilia (Editorial Board Member) Journal of Thrombosis Hemostasis Annals of Hematology Thrombosis Research Thrombosis and Haemostasis Pediatrics in Review J of the American Board of Family Medicine
OTHER SERVICE Member of the Steering committee for a multicenter trial on the Real
life use of Extended half life products in patients with hemophilia Baxter ITP Regional Advisory Board Novo Nordisk Translational Advisory Board Baxter Bleed Reduction Advisory Board Baxalta Optimizing Prophylaxis in hemophilia Advisory Board- Chair Baxalta Challenges in Inhibitor management ndash Co-Chair
TEACHING Teaching at Wayne State University
Medical students Year III students while primary attending on HemOnc inpatient unit (1shy2 mosyr)Year IV students on elective rotation in hematologyoncology clinic
ResidentsFellowsInpatientbedside teaching on daily basis while primary attending on 6 West (25-35 mosyr) and while on-call on weekends1-2 lecturesyear on basic coagulation studies and bleeding disordersActively collaborate with residents and students to encourage manuscript writing and clinical studies See pub 13 Case reports31323335 Review articles 39 and Book chapter 6
Faculty (eg CME)ECMO Anticoagulation- Invited seminar at the Joint ICUCV Surgeryconference at Childrens Hospital of Michigan
Thromboelastography- guide to use in anesthesiology Invited seminar atthe CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan
Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital ofMichigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI
Teaching at other institutionsFaculty (eg CME)
Title Laboratory Diagnosis and Therapeutic Monitoring in PediatricHemophilia Avoiding Pifalls Optimizing OutcomesCredits 15 CME Activity Type CME Activity Symposium at the Annual American Society of Pediatric HemaotologyOncology Meeting May 12 2016Description A comprehensive Review of the current issues and challenges related to laboratory assessment of Pedaitric Hemophiliaprovided by GYoung MD DAdcock MD and Meera Chitlur MD
Dec 2016
Aug 2014
Nov 2011
May 2016
7
Faculty (eg CME)Title Hemophilia- A Primer Credits 15 CME Activity Type Online CME ActivityDescription Comprehensive Review of diagnosis and management ofHemophilia by Madhvi Rajpurkar MD and Meera Chitlur MD
Title Differential Diagnosis in a Young Child With Excessive Bleeding Epistaxis and BruisingCredits 075 CME 06 CNE | Expires 62016 Activity Type Online CME ActivityDescription This case-focused learning activity brings together bleedingexperts Mortimer Poncz MD and Meera Chitlur MD to discuss the case of a child born of a non-consanguineous marriage with excessive post-traumatic bleeding and epistaxis
Title Cyberoundsreg Unexplained Bleeding in Hospitalized Patients Credits 10 AMA 10 ANCCActivity Type Online CME ActivityDescription Given the approximately 365 million hospital admissions inthe United States an unexplained bleeding scenario could very well beone that you are required to manage someday Would you know how to handle it Meera B Chitlur- faculty presenter
Title Hemophilia Today What Clinicians Really Want to Knowrdquo Credits 15 CME 15 CNEActivity Type Online CME ActivityDescription This educational activity features three renowned experts inthe field of bleeding disorders Victor S Blanchette MD Meera B Chitlur MD and Steven W Pipe MD address some common gaps inknowledge by providing professional opinion on current and emergingtherapies and clinical challenges associated with managing patients withhemophilia
Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker Cincinnati ChildrenrsquosHospital and Medical center
Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio
Title Current Strategies for the Surgical Management of Patients With Congenital Bleeding DisordersCredits Not for credit Activity Type Online CME ActivityActivity Description Symposium held in conjunction with the 2011 ASPHO (American Society of Pediatric HematologyOncology) AnnualMeeting Victor S Blanchette MD FRCP Steven W Pipe MD and Meera B Chitlur MD Issues pertaining to the perioperative management of patients with congenital bleeding disorders As part oftheir discussion these noted experts address hemophilic and nonshyhemophilic inhibitors of coagulation standard and emerging coagulation tests and novel and experimental clotting factors
Jul 2015
Jul 2015
Nov 2013
Oct 2012
Oct 2012
Dec 2012
May 2011
8
Faculty (eg CME) Apr 2011 Title Treatment Decisions and Clinical Outcomes in Hemophilia B Patients With Inhibitors Credits 075 CME 10 CNE Activity Type Online CME Activity Activity Description In this vodcast learning activity Meera Chitlur MD explains the history prevalence of FIX deficiency and various treatment modalities available She also explores the possible causes for the co-manifestation of inhibitor development and allergic reactions and the usefulness of registries in monitoring the occurrence of inhibitors in patients with hemophilia B
Aug 2010 Global Assays in Hemostasis Invited speaker for Grand Rounds atDevaraj Urs Medical College Kolar Karnataka India
Aug 2009 Title FIX Deficiency and Inhibitors Report From the ISTH-SSC International Registry Credits 075 CME 10 CNE Activity Type Online CME ActivityActivity Description The advent of registry databases to aid collection ofinformation on hemophilia B has helped further the understanding of FIXdeficiency and inhibitors within the scientific community In this learningactivity Meera Chitlur MD discusses the importance of the ISTH-SSCInternational FIX Inhibitor Registry in addition to etiology of severe reactions associated with appearance of inhibitors in hemophilia B
Mentorship 2008DrShilpa Jain MD Mentored research project entitled ldquoThrombin generationin children with moderate to severe hemophiliardquo with year III Pediatric Resident Dr S Jain who was awarded first place in the Resident Research Competition 2009DrBMehta PGY2 mentor for research project on thrombin generation inpatients on Ventricular Assist Devicersquos 2009 2009-2011 Dr S Veluswamy Mentor to PGY3 resident 2012-2014 DrAbdullah Mentor to PGY2 resident 2012-2013 DrsAyesha Zia MD Fellow Mentor for fellow projects 2010-2013 DrLRao MD Fellow Clinical and Research Mentor 2013-2015 DrTSarkar Fellow Research mentor 2005Visiting professorscientists DrDSosothikul from Thailand 2007-2008
DrAlphan Kupesiz from Turkey May 2013 DrMaissaa Janbain MD Tulane University Externship mentor April 2013 Dr Indrayas Woldie MD Karmanos Cancer Institute WSU May2015 DrJing Christine Ye MD Karmanos Cancer Institute WSU July 2015 Dr Yasmina Abajas University of North Carolina Global Assays Training 2016-2017 Dr Katherine Regling PGY2-3 2016-2018 DrBettina Joi Isaac Fellow Research mentor 2016-2018 DrSarah Ramiz Fellow Research mentor
GRANTS CONTRACTS AND OTHER FUNDING
Active Grants and Contracts Role Site Principal Investigator Title Cascade Hemophilia Consortium Grant Sponsor Cascade Hemophilia Consortium
9 Trial StartEnc Date 6115-53116 (renewed yearly) Funding $221161
Active Grants and Contracts Role Site Principal Investigator Title My Life Our Future (MLOF2) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Period of Support 1115-123115 Funding Direct cost $1468 Indirect cost $38
Role Site Principal Investigator Title Validation of the ISTH-BAT (International Society on Thrombosis and Haemostasis Bleeding Assessment Tool) in Hemophilia Carriers Sponsor Queenrsquos University Grant StartEnd Date 32014-12016 Funding Direct cost $5750 Indirect cost $910
Role Site Principal Investigator Title Maternal and Child Health Bureau (MCHB) Comprehensive Care Sponsor Maternal and Child Health Bureau Grant StartEnd date 2014-2015 (renewed yearly) Funding $35000
Role Site Principal Investigator Title My Life Our Future (MLOF) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Trial StartEnc Date 12914-12816 Funding Direct cost $2748 Indirect cost $752
Role Co Investigator Title Hemophilia Inhibitor Research Study Ph III (HIRS) Site PI MRajpurkar MD Source Center for Disease Control Period of Support 1092014 ndash 9302015 Direct costs $20340 (based on enrollment)
Role Site Principal Investigator Title Hemophilia Foundation of MI Sponsor ATHN Trial StartEnc Date 9302014-92915 (renewed yearly) Funding $37000
Role Co Investigator Title Molecular and clinical biology of von Willebrandrsquos Disease (Zimmerman project) Source National Institutes of Science (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of Support 20114-013117 Direct Cost $16413 (Based on enrollment)
10
Active Grants and Contracts
Role Co Investigator Title Comparative Effectiveness in the Diagnosis of vWD Source National Institutes of Health (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of support 2114-13117 Direct Cost $33534 (Based on enrollment)
Role Co-Investigator Title Multicenter Evaluation of the Duration of Therapy for Thrombosis in Children Site PI MRajpurkar Source All Childrens Research Institute Inc Period of Support 01012014-12312018 Direct cost $9230
Role Site Principal Investigator Title Personalized Medicine in Hemophilia Sponsor Childrens Hospital of Los Angeles Trial StartEnc Date 7113-63016 Funding Direct cost $33041 Indirect cost $17181
Role Principal Investigator Title Regional and Cultural Variance in Perceptions Pertaining to Research Participation Sponsor None Trial StartEnd Date 0513-122015 Funding NA
Role Principal Investigator Percent Effort 20 Title Thromboelastography in Severe Hemophilia Following Clotting Factor Replacement Therapy The primary objective is to evaluate the utility of Thromboelastography in the assessment of pharmacokinetics after factor replacement in patients with severemoderately severe hemophilia Sponsor Childrens Research Center of Michigan Grant StartEnd Date 22008- 122015 (closed to enrollment Data analysis ongoing) Funding Direct cost $45910 Indirect cost 1069342
Role Site PI Title Pediatric and adult intercontinental registry on chronic ITP Sponsor University Childrenrsquos Hospital Basel Switzerland Trial StartEnd Date 404 to 62016 80 patients entered to date from our Center Funding NA
Role Co- Investigator Title A Randomized Open-Label Active Controlled Safety and Extrapolated Efficacy Study in Pediatric Subjects Requiring Anticoagulation for the Treatment of a Venous Thromboembolic Event Source Pfizer Inc
11 Period of support 612015- 5312020 Total Direct Cost $63802 (based on enrollment)
Clinical Trials Activities Role Site Principal Investigator Title Use of rFXIII in treatment of congenital FXIII deficiency a prospective multi-centre observational study- MENTOR 6 (25RGV) Sponsor Novo Nordisk Trial StartEnd Date 11515-11417 Funding $25611
Role Site Principal Investigator Title Study of Prophylaxis ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated with ADVATE or RIXUBIS (SPACE) (25RE7) Sponsor Baxter Healthcare Corp Trial startEnd Date 12914-12816 Funding Direct cost $9541 Indirect cost $2481 (based on patient enrollment)
Role Co Investigator Title Oral Rivaroxaban in children with venous thrombosis a 30 day open label active controlled randomized study of the safety efficacy and the pharmacokinetic and pharmacodynamic properties of oral rivaroxaban in children with venous thrombosis Source Bayer Corporation Period of support 062314- 04082016 Total Direct Cost 74352
Role Co Investigator Title An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune (Idiopathic) Thrombocytopenia Purpura (ITP) Site PI MCallaghan Sponsor Amgen Inc Trial StartEnd Date 032213 - 32118 Funding $130870
Role Site Principal- Investigator Title PH3 NN7088-3859 A Multi-National Trial Evaluating Safety and Efficacy Including Pharmacokinetics of NNC 0159-0000-1003 when Administered for Treatment and Prophylaxis of Bleeding in Patients with Haemophilia A - Pathfinder N8 GP (25QPY) Sponsor Novo Nordisk Trial startEnd Date 11813- 102121 Funding Direct cost $61538 Indirect cost $16000
Role Co- Primary Investigator Title Safety and Efficacy of NNC 0155-0000-0004 in Prevention and Treatment of Bleeds in Pediatric Previously Untreated Patients with Haemophilia A (Guardian) N8 PUPs Source Novo Nordisk Period of support 091212- 04082016 Total Cost $15270 (based on enrollment)
12
Clinical Trials Activities Role Co-Investigator Title Rescue Immune-tolerance Study in ITI Experienced Patients shyResist Experienced Source City of Hope Period of support 08152012-02122015 (Study is closed to accrual but following subjects enrolled) Direct Cost$ 5750
Role Co Investigator Title Single-dose pilot study of rivaroxaban in pediatric subjects with venous thromboembolism-12892 Source Bayer Corporation Site PI MRajpurkar Period of Support 061512-123115 Total Direct Cost $83961 (based on enrollment)
Role Co-investigator Title A Phase 3 Randomized Double Blind Placebo Controlled Study to Determine the Safety and Efficacy of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune Thrombocytopenia (ITP) Principal Investigator M Callaghan Sponsor Amgen Inc Trial StartEnd Date 1211-0414 Funding $56000
Role Co Investigator Title - A Three Month Prospective Open Label Study of Therapy with FRAGMINreg (Dalteparin Sodium Injection) in Children with Malignancies and Venous Thromboembolism - FRAG-A001-201 Source Easai Inc Site PI MRajpurkar Period of Support 092810 - 052115 Total Direct Cost$5285742
Role Site Principal Investigator Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (25PYE) Sponsor Novo Nordisk Inc Trial startEnd Date 22309-122115 Funding Direct cost $44005 Indirect cost $11441
Completed Studies
Role Site Principal Investigator Title Evaluate the Activity a Site Specific of BDomain Deleted (BDD) Pegylated Recombinant FVIII Protein (BAY 94-9027) in Plasma Samples Measured with both Chromogenic and One Stage Assays Sponsor Bayer Trial StartEnc Date 8115- 8116 Funding $696400
13 Completed Studies
Role Co-investigator Title Safety and Efficacy of N8 in prevention and treatment of bleeds in pediatric Previously treated patients with Hemophilia A Site PI MRajpurkar Sponsor Novo Nordisk Trial StartEnd Date 1210 to 911 Funding $381729
Role Site PI Title 3760- Phase 3b Trial Investigating the Pharmacokinetics amp Safety Profile of Single IV Dose of rFXIII in Paediatric (1 to less than 6 Years Old) Subjects with Congenital FXIII A-Subunit Deficiency Sponsor Novo Nordisk Inc Trial StartEnd Date 1110-0112 Funding $ 4315752
Role Co-investigator Title Universal data and serum specimen collection (UDC) system for hemophilia Sponsor Centers for Disease Control (CDC) Site PI JLusher Trial StartEnd Date 0610 to 511 Funding $48000
Role Site PI for multi center trial Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (N13 3720) (Mentor 2) Sponsor Novo Nordisk Inc Trial StartEnd Date 0410- 1214 Funding $ 5544504
Role Principal Investigator Title Prospective ADVATE ITI Registry (Pair) Sponsor Baxter Trial StartEnd Date 210 -411 Funding $2000
Role Co-investigator Title Mechanisms of Race Based Differences in Factor VIII Immunogenicity in Hemophilia Sponsor NIH Supleveda Site PI JLusher Trial StartEnd Date 0909 to 0911 Funding $70000
Role Co-investigator Title Treatment of Congenital Factor VII deficiency A prospective observational studySTER [Seven Deficiency Treatment Registry] Site PI MRajpurkar Sponsor Quintiles Inc Trial StartEnd Date 709 to 1210 Funding $2800
14 Completed Studies
Role Site PI for multi center trial Title Prophylaxis Patient Case Collection (PRO-PACT) Sponsor Novo Nordisk Inc Trial StartEnd Date 409-0510 Funding $3984
Role Co-investigator Title Phase 1 Prospective Randomized Crossover Study to Compare the Pharmacokinetics and Safety of rAHF-PFM Reconstituted in 2mL versus 5mL SWFI in Previously Treated Severe Hemophilia A Patients Site PI JLusher Sponsor Baxter BioScience Trial StartEnd Date 208- 310 Funding $34272
Role Consultant Title Thromboelastographic evaluation of hypercoagulability after Fontanrsquos surgery Site PI MRajpurkar Sponsor CRCM Trial StartEnd Date 706 to 1210 Funding $ 32507
Role Site PI Title Recombinant anti-hemophilic factor manufactured and formulated without added human or animal proteins (rAHF PFM) evaluation of immunogenicity efficacy and safety in previously untreated patients with hemophilia A (PUP study) Sponsor Baxter Bioscience Trial StartEnd Date 404-0909 Funding $32582
Role Co-investigator Title Chiron Gene Therapy Long Term Safety Follow-up Site PI JLusher Sponsor Chiron Corp Trial StartEnd Date 0800 to 1210 Funding $1771
PUBLICATIONS Peer-Reviewed Publications
Reports of Original Work Notes Trainee or student mentored by MC Citation data from Web of Science
1 Iorio A Keepanasseril A Foster G Navarro-Ruan T McEneny-King A Edginton AN Thabane L WAPPS-Hemo co-investigator network Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Study Protocol JMIR Res Protoc 2016 Dec 155(4)e239
2 James PD Mahlangu J Bidlingmaier C Mingot-Castellano ME Chitlur M Fogarty PF Cuker A Mancuso ME Holme PA Grabell J Satkunam N Hopman WM Mathew P Global Emerging HEmostasis Experts Panel (GEHEP) Evaluation of the utility of the ISTH-BAT in haemophilia carriers a multinational studyHaemophilia 2016 Nov22(6)912-918
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
6 Scholarly Service
Review of Manuscripts J of Biomaterials Science Polymer edition Pediatric Blood and Cancer Haemophilia (Editorial Board Member) Journal of Thrombosis Hemostasis Annals of Hematology Thrombosis Research Thrombosis and Haemostasis Pediatrics in Review J of the American Board of Family Medicine
OTHER SERVICE Member of the Steering committee for a multicenter trial on the Real
life use of Extended half life products in patients with hemophilia Baxter ITP Regional Advisory Board Novo Nordisk Translational Advisory Board Baxter Bleed Reduction Advisory Board Baxalta Optimizing Prophylaxis in hemophilia Advisory Board- Chair Baxalta Challenges in Inhibitor management ndash Co-Chair
TEACHING Teaching at Wayne State University
Medical students Year III students while primary attending on HemOnc inpatient unit (1shy2 mosyr)Year IV students on elective rotation in hematologyoncology clinic
ResidentsFellowsInpatientbedside teaching on daily basis while primary attending on 6 West (25-35 mosyr) and while on-call on weekends1-2 lecturesyear on basic coagulation studies and bleeding disordersActively collaborate with residents and students to encourage manuscript writing and clinical studies See pub 13 Case reports31323335 Review articles 39 and Book chapter 6
Faculty (eg CME)ECMO Anticoagulation- Invited seminar at the Joint ICUCV Surgeryconference at Childrens Hospital of Michigan
Thromboelastography- guide to use in anesthesiology Invited seminar atthe CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan
Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital ofMichigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI
Teaching at other institutionsFaculty (eg CME)
Title Laboratory Diagnosis and Therapeutic Monitoring in PediatricHemophilia Avoiding Pifalls Optimizing OutcomesCredits 15 CME Activity Type CME Activity Symposium at the Annual American Society of Pediatric HemaotologyOncology Meeting May 12 2016Description A comprehensive Review of the current issues and challenges related to laboratory assessment of Pedaitric Hemophiliaprovided by GYoung MD DAdcock MD and Meera Chitlur MD
Dec 2016
Aug 2014
Nov 2011
May 2016
7
Faculty (eg CME)Title Hemophilia- A Primer Credits 15 CME Activity Type Online CME ActivityDescription Comprehensive Review of diagnosis and management ofHemophilia by Madhvi Rajpurkar MD and Meera Chitlur MD
Title Differential Diagnosis in a Young Child With Excessive Bleeding Epistaxis and BruisingCredits 075 CME 06 CNE | Expires 62016 Activity Type Online CME ActivityDescription This case-focused learning activity brings together bleedingexperts Mortimer Poncz MD and Meera Chitlur MD to discuss the case of a child born of a non-consanguineous marriage with excessive post-traumatic bleeding and epistaxis
Title Cyberoundsreg Unexplained Bleeding in Hospitalized Patients Credits 10 AMA 10 ANCCActivity Type Online CME ActivityDescription Given the approximately 365 million hospital admissions inthe United States an unexplained bleeding scenario could very well beone that you are required to manage someday Would you know how to handle it Meera B Chitlur- faculty presenter
Title Hemophilia Today What Clinicians Really Want to Knowrdquo Credits 15 CME 15 CNEActivity Type Online CME ActivityDescription This educational activity features three renowned experts inthe field of bleeding disorders Victor S Blanchette MD Meera B Chitlur MD and Steven W Pipe MD address some common gaps inknowledge by providing professional opinion on current and emergingtherapies and clinical challenges associated with managing patients withhemophilia
Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker Cincinnati ChildrenrsquosHospital and Medical center
Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio
Title Current Strategies for the Surgical Management of Patients With Congenital Bleeding DisordersCredits Not for credit Activity Type Online CME ActivityActivity Description Symposium held in conjunction with the 2011 ASPHO (American Society of Pediatric HematologyOncology) AnnualMeeting Victor S Blanchette MD FRCP Steven W Pipe MD and Meera B Chitlur MD Issues pertaining to the perioperative management of patients with congenital bleeding disorders As part oftheir discussion these noted experts address hemophilic and nonshyhemophilic inhibitors of coagulation standard and emerging coagulation tests and novel and experimental clotting factors
Jul 2015
Jul 2015
Nov 2013
Oct 2012
Oct 2012
Dec 2012
May 2011
8
Faculty (eg CME) Apr 2011 Title Treatment Decisions and Clinical Outcomes in Hemophilia B Patients With Inhibitors Credits 075 CME 10 CNE Activity Type Online CME Activity Activity Description In this vodcast learning activity Meera Chitlur MD explains the history prevalence of FIX deficiency and various treatment modalities available She also explores the possible causes for the co-manifestation of inhibitor development and allergic reactions and the usefulness of registries in monitoring the occurrence of inhibitors in patients with hemophilia B
Aug 2010 Global Assays in Hemostasis Invited speaker for Grand Rounds atDevaraj Urs Medical College Kolar Karnataka India
Aug 2009 Title FIX Deficiency and Inhibitors Report From the ISTH-SSC International Registry Credits 075 CME 10 CNE Activity Type Online CME ActivityActivity Description The advent of registry databases to aid collection ofinformation on hemophilia B has helped further the understanding of FIXdeficiency and inhibitors within the scientific community In this learningactivity Meera Chitlur MD discusses the importance of the ISTH-SSCInternational FIX Inhibitor Registry in addition to etiology of severe reactions associated with appearance of inhibitors in hemophilia B
Mentorship 2008DrShilpa Jain MD Mentored research project entitled ldquoThrombin generationin children with moderate to severe hemophiliardquo with year III Pediatric Resident Dr S Jain who was awarded first place in the Resident Research Competition 2009DrBMehta PGY2 mentor for research project on thrombin generation inpatients on Ventricular Assist Devicersquos 2009 2009-2011 Dr S Veluswamy Mentor to PGY3 resident 2012-2014 DrAbdullah Mentor to PGY2 resident 2012-2013 DrsAyesha Zia MD Fellow Mentor for fellow projects 2010-2013 DrLRao MD Fellow Clinical and Research Mentor 2013-2015 DrTSarkar Fellow Research mentor 2005Visiting professorscientists DrDSosothikul from Thailand 2007-2008
DrAlphan Kupesiz from Turkey May 2013 DrMaissaa Janbain MD Tulane University Externship mentor April 2013 Dr Indrayas Woldie MD Karmanos Cancer Institute WSU May2015 DrJing Christine Ye MD Karmanos Cancer Institute WSU July 2015 Dr Yasmina Abajas University of North Carolina Global Assays Training 2016-2017 Dr Katherine Regling PGY2-3 2016-2018 DrBettina Joi Isaac Fellow Research mentor 2016-2018 DrSarah Ramiz Fellow Research mentor
GRANTS CONTRACTS AND OTHER FUNDING
Active Grants and Contracts Role Site Principal Investigator Title Cascade Hemophilia Consortium Grant Sponsor Cascade Hemophilia Consortium
9 Trial StartEnc Date 6115-53116 (renewed yearly) Funding $221161
Active Grants and Contracts Role Site Principal Investigator Title My Life Our Future (MLOF2) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Period of Support 1115-123115 Funding Direct cost $1468 Indirect cost $38
Role Site Principal Investigator Title Validation of the ISTH-BAT (International Society on Thrombosis and Haemostasis Bleeding Assessment Tool) in Hemophilia Carriers Sponsor Queenrsquos University Grant StartEnd Date 32014-12016 Funding Direct cost $5750 Indirect cost $910
Role Site Principal Investigator Title Maternal and Child Health Bureau (MCHB) Comprehensive Care Sponsor Maternal and Child Health Bureau Grant StartEnd date 2014-2015 (renewed yearly) Funding $35000
Role Site Principal Investigator Title My Life Our Future (MLOF) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Trial StartEnc Date 12914-12816 Funding Direct cost $2748 Indirect cost $752
Role Co Investigator Title Hemophilia Inhibitor Research Study Ph III (HIRS) Site PI MRajpurkar MD Source Center for Disease Control Period of Support 1092014 ndash 9302015 Direct costs $20340 (based on enrollment)
Role Site Principal Investigator Title Hemophilia Foundation of MI Sponsor ATHN Trial StartEnc Date 9302014-92915 (renewed yearly) Funding $37000
Role Co Investigator Title Molecular and clinical biology of von Willebrandrsquos Disease (Zimmerman project) Source National Institutes of Science (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of Support 20114-013117 Direct Cost $16413 (Based on enrollment)
10
Active Grants and Contracts
Role Co Investigator Title Comparative Effectiveness in the Diagnosis of vWD Source National Institutes of Health (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of support 2114-13117 Direct Cost $33534 (Based on enrollment)
Role Co-Investigator Title Multicenter Evaluation of the Duration of Therapy for Thrombosis in Children Site PI MRajpurkar Source All Childrens Research Institute Inc Period of Support 01012014-12312018 Direct cost $9230
Role Site Principal Investigator Title Personalized Medicine in Hemophilia Sponsor Childrens Hospital of Los Angeles Trial StartEnc Date 7113-63016 Funding Direct cost $33041 Indirect cost $17181
Role Principal Investigator Title Regional and Cultural Variance in Perceptions Pertaining to Research Participation Sponsor None Trial StartEnd Date 0513-122015 Funding NA
Role Principal Investigator Percent Effort 20 Title Thromboelastography in Severe Hemophilia Following Clotting Factor Replacement Therapy The primary objective is to evaluate the utility of Thromboelastography in the assessment of pharmacokinetics after factor replacement in patients with severemoderately severe hemophilia Sponsor Childrens Research Center of Michigan Grant StartEnd Date 22008- 122015 (closed to enrollment Data analysis ongoing) Funding Direct cost $45910 Indirect cost 1069342
Role Site PI Title Pediatric and adult intercontinental registry on chronic ITP Sponsor University Childrenrsquos Hospital Basel Switzerland Trial StartEnd Date 404 to 62016 80 patients entered to date from our Center Funding NA
Role Co- Investigator Title A Randomized Open-Label Active Controlled Safety and Extrapolated Efficacy Study in Pediatric Subjects Requiring Anticoagulation for the Treatment of a Venous Thromboembolic Event Source Pfizer Inc
11 Period of support 612015- 5312020 Total Direct Cost $63802 (based on enrollment)
Clinical Trials Activities Role Site Principal Investigator Title Use of rFXIII in treatment of congenital FXIII deficiency a prospective multi-centre observational study- MENTOR 6 (25RGV) Sponsor Novo Nordisk Trial StartEnd Date 11515-11417 Funding $25611
Role Site Principal Investigator Title Study of Prophylaxis ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated with ADVATE or RIXUBIS (SPACE) (25RE7) Sponsor Baxter Healthcare Corp Trial startEnd Date 12914-12816 Funding Direct cost $9541 Indirect cost $2481 (based on patient enrollment)
Role Co Investigator Title Oral Rivaroxaban in children with venous thrombosis a 30 day open label active controlled randomized study of the safety efficacy and the pharmacokinetic and pharmacodynamic properties of oral rivaroxaban in children with venous thrombosis Source Bayer Corporation Period of support 062314- 04082016 Total Direct Cost 74352
Role Co Investigator Title An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune (Idiopathic) Thrombocytopenia Purpura (ITP) Site PI MCallaghan Sponsor Amgen Inc Trial StartEnd Date 032213 - 32118 Funding $130870
Role Site Principal- Investigator Title PH3 NN7088-3859 A Multi-National Trial Evaluating Safety and Efficacy Including Pharmacokinetics of NNC 0159-0000-1003 when Administered for Treatment and Prophylaxis of Bleeding in Patients with Haemophilia A - Pathfinder N8 GP (25QPY) Sponsor Novo Nordisk Trial startEnd Date 11813- 102121 Funding Direct cost $61538 Indirect cost $16000
Role Co- Primary Investigator Title Safety and Efficacy of NNC 0155-0000-0004 in Prevention and Treatment of Bleeds in Pediatric Previously Untreated Patients with Haemophilia A (Guardian) N8 PUPs Source Novo Nordisk Period of support 091212- 04082016 Total Cost $15270 (based on enrollment)
12
Clinical Trials Activities Role Co-Investigator Title Rescue Immune-tolerance Study in ITI Experienced Patients shyResist Experienced Source City of Hope Period of support 08152012-02122015 (Study is closed to accrual but following subjects enrolled) Direct Cost$ 5750
Role Co Investigator Title Single-dose pilot study of rivaroxaban in pediatric subjects with venous thromboembolism-12892 Source Bayer Corporation Site PI MRajpurkar Period of Support 061512-123115 Total Direct Cost $83961 (based on enrollment)
Role Co-investigator Title A Phase 3 Randomized Double Blind Placebo Controlled Study to Determine the Safety and Efficacy of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune Thrombocytopenia (ITP) Principal Investigator M Callaghan Sponsor Amgen Inc Trial StartEnd Date 1211-0414 Funding $56000
Role Co Investigator Title - A Three Month Prospective Open Label Study of Therapy with FRAGMINreg (Dalteparin Sodium Injection) in Children with Malignancies and Venous Thromboembolism - FRAG-A001-201 Source Easai Inc Site PI MRajpurkar Period of Support 092810 - 052115 Total Direct Cost$5285742
Role Site Principal Investigator Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (25PYE) Sponsor Novo Nordisk Inc Trial startEnd Date 22309-122115 Funding Direct cost $44005 Indirect cost $11441
Completed Studies
Role Site Principal Investigator Title Evaluate the Activity a Site Specific of BDomain Deleted (BDD) Pegylated Recombinant FVIII Protein (BAY 94-9027) in Plasma Samples Measured with both Chromogenic and One Stage Assays Sponsor Bayer Trial StartEnc Date 8115- 8116 Funding $696400
13 Completed Studies
Role Co-investigator Title Safety and Efficacy of N8 in prevention and treatment of bleeds in pediatric Previously treated patients with Hemophilia A Site PI MRajpurkar Sponsor Novo Nordisk Trial StartEnd Date 1210 to 911 Funding $381729
Role Site PI Title 3760- Phase 3b Trial Investigating the Pharmacokinetics amp Safety Profile of Single IV Dose of rFXIII in Paediatric (1 to less than 6 Years Old) Subjects with Congenital FXIII A-Subunit Deficiency Sponsor Novo Nordisk Inc Trial StartEnd Date 1110-0112 Funding $ 4315752
Role Co-investigator Title Universal data and serum specimen collection (UDC) system for hemophilia Sponsor Centers for Disease Control (CDC) Site PI JLusher Trial StartEnd Date 0610 to 511 Funding $48000
Role Site PI for multi center trial Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (N13 3720) (Mentor 2) Sponsor Novo Nordisk Inc Trial StartEnd Date 0410- 1214 Funding $ 5544504
Role Principal Investigator Title Prospective ADVATE ITI Registry (Pair) Sponsor Baxter Trial StartEnd Date 210 -411 Funding $2000
Role Co-investigator Title Mechanisms of Race Based Differences in Factor VIII Immunogenicity in Hemophilia Sponsor NIH Supleveda Site PI JLusher Trial StartEnd Date 0909 to 0911 Funding $70000
Role Co-investigator Title Treatment of Congenital Factor VII deficiency A prospective observational studySTER [Seven Deficiency Treatment Registry] Site PI MRajpurkar Sponsor Quintiles Inc Trial StartEnd Date 709 to 1210 Funding $2800
14 Completed Studies
Role Site PI for multi center trial Title Prophylaxis Patient Case Collection (PRO-PACT) Sponsor Novo Nordisk Inc Trial StartEnd Date 409-0510 Funding $3984
Role Co-investigator Title Phase 1 Prospective Randomized Crossover Study to Compare the Pharmacokinetics and Safety of rAHF-PFM Reconstituted in 2mL versus 5mL SWFI in Previously Treated Severe Hemophilia A Patients Site PI JLusher Sponsor Baxter BioScience Trial StartEnd Date 208- 310 Funding $34272
Role Consultant Title Thromboelastographic evaluation of hypercoagulability after Fontanrsquos surgery Site PI MRajpurkar Sponsor CRCM Trial StartEnd Date 706 to 1210 Funding $ 32507
Role Site PI Title Recombinant anti-hemophilic factor manufactured and formulated without added human or animal proteins (rAHF PFM) evaluation of immunogenicity efficacy and safety in previously untreated patients with hemophilia A (PUP study) Sponsor Baxter Bioscience Trial StartEnd Date 404-0909 Funding $32582
Role Co-investigator Title Chiron Gene Therapy Long Term Safety Follow-up Site PI JLusher Sponsor Chiron Corp Trial StartEnd Date 0800 to 1210 Funding $1771
PUBLICATIONS Peer-Reviewed Publications
Reports of Original Work Notes Trainee or student mentored by MC Citation data from Web of Science
1 Iorio A Keepanasseril A Foster G Navarro-Ruan T McEneny-King A Edginton AN Thabane L WAPPS-Hemo co-investigator network Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Study Protocol JMIR Res Protoc 2016 Dec 155(4)e239
2 James PD Mahlangu J Bidlingmaier C Mingot-Castellano ME Chitlur M Fogarty PF Cuker A Mancuso ME Holme PA Grabell J Satkunam N Hopman WM Mathew P Global Emerging HEmostasis Experts Panel (GEHEP) Evaluation of the utility of the ISTH-BAT in haemophilia carriers a multinational studyHaemophilia 2016 Nov22(6)912-918
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
7
Faculty (eg CME)Title Hemophilia- A Primer Credits 15 CME Activity Type Online CME ActivityDescription Comprehensive Review of diagnosis and management ofHemophilia by Madhvi Rajpurkar MD and Meera Chitlur MD
Title Differential Diagnosis in a Young Child With Excessive Bleeding Epistaxis and BruisingCredits 075 CME 06 CNE | Expires 62016 Activity Type Online CME ActivityDescription This case-focused learning activity brings together bleedingexperts Mortimer Poncz MD and Meera Chitlur MD to discuss the case of a child born of a non-consanguineous marriage with excessive post-traumatic bleeding and epistaxis
Title Cyberoundsreg Unexplained Bleeding in Hospitalized Patients Credits 10 AMA 10 ANCCActivity Type Online CME ActivityDescription Given the approximately 365 million hospital admissions inthe United States an unexplained bleeding scenario could very well beone that you are required to manage someday Would you know how to handle it Meera B Chitlur- faculty presenter
Title Hemophilia Today What Clinicians Really Want to Knowrdquo Credits 15 CME 15 CNEActivity Type Online CME ActivityDescription This educational activity features three renowned experts inthe field of bleeding disorders Victor S Blanchette MD Meera B Chitlur MD and Steven W Pipe MD address some common gaps inknowledge by providing professional opinion on current and emergingtherapies and clinical challenges associated with managing patients withhemophilia
Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker Cincinnati ChildrenrsquosHospital and Medical center
Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio
Title Current Strategies for the Surgical Management of Patients With Congenital Bleeding DisordersCredits Not for credit Activity Type Online CME ActivityActivity Description Symposium held in conjunction with the 2011 ASPHO (American Society of Pediatric HematologyOncology) AnnualMeeting Victor S Blanchette MD FRCP Steven W Pipe MD and Meera B Chitlur MD Issues pertaining to the perioperative management of patients with congenital bleeding disorders As part oftheir discussion these noted experts address hemophilic and nonshyhemophilic inhibitors of coagulation standard and emerging coagulation tests and novel and experimental clotting factors
Jul 2015
Jul 2015
Nov 2013
Oct 2012
Oct 2012
Dec 2012
May 2011
8
Faculty (eg CME) Apr 2011 Title Treatment Decisions and Clinical Outcomes in Hemophilia B Patients With Inhibitors Credits 075 CME 10 CNE Activity Type Online CME Activity Activity Description In this vodcast learning activity Meera Chitlur MD explains the history prevalence of FIX deficiency and various treatment modalities available She also explores the possible causes for the co-manifestation of inhibitor development and allergic reactions and the usefulness of registries in monitoring the occurrence of inhibitors in patients with hemophilia B
Aug 2010 Global Assays in Hemostasis Invited speaker for Grand Rounds atDevaraj Urs Medical College Kolar Karnataka India
Aug 2009 Title FIX Deficiency and Inhibitors Report From the ISTH-SSC International Registry Credits 075 CME 10 CNE Activity Type Online CME ActivityActivity Description The advent of registry databases to aid collection ofinformation on hemophilia B has helped further the understanding of FIXdeficiency and inhibitors within the scientific community In this learningactivity Meera Chitlur MD discusses the importance of the ISTH-SSCInternational FIX Inhibitor Registry in addition to etiology of severe reactions associated with appearance of inhibitors in hemophilia B
Mentorship 2008DrShilpa Jain MD Mentored research project entitled ldquoThrombin generationin children with moderate to severe hemophiliardquo with year III Pediatric Resident Dr S Jain who was awarded first place in the Resident Research Competition 2009DrBMehta PGY2 mentor for research project on thrombin generation inpatients on Ventricular Assist Devicersquos 2009 2009-2011 Dr S Veluswamy Mentor to PGY3 resident 2012-2014 DrAbdullah Mentor to PGY2 resident 2012-2013 DrsAyesha Zia MD Fellow Mentor for fellow projects 2010-2013 DrLRao MD Fellow Clinical and Research Mentor 2013-2015 DrTSarkar Fellow Research mentor 2005Visiting professorscientists DrDSosothikul from Thailand 2007-2008
DrAlphan Kupesiz from Turkey May 2013 DrMaissaa Janbain MD Tulane University Externship mentor April 2013 Dr Indrayas Woldie MD Karmanos Cancer Institute WSU May2015 DrJing Christine Ye MD Karmanos Cancer Institute WSU July 2015 Dr Yasmina Abajas University of North Carolina Global Assays Training 2016-2017 Dr Katherine Regling PGY2-3 2016-2018 DrBettina Joi Isaac Fellow Research mentor 2016-2018 DrSarah Ramiz Fellow Research mentor
GRANTS CONTRACTS AND OTHER FUNDING
Active Grants and Contracts Role Site Principal Investigator Title Cascade Hemophilia Consortium Grant Sponsor Cascade Hemophilia Consortium
9 Trial StartEnc Date 6115-53116 (renewed yearly) Funding $221161
Active Grants and Contracts Role Site Principal Investigator Title My Life Our Future (MLOF2) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Period of Support 1115-123115 Funding Direct cost $1468 Indirect cost $38
Role Site Principal Investigator Title Validation of the ISTH-BAT (International Society on Thrombosis and Haemostasis Bleeding Assessment Tool) in Hemophilia Carriers Sponsor Queenrsquos University Grant StartEnd Date 32014-12016 Funding Direct cost $5750 Indirect cost $910
Role Site Principal Investigator Title Maternal and Child Health Bureau (MCHB) Comprehensive Care Sponsor Maternal and Child Health Bureau Grant StartEnd date 2014-2015 (renewed yearly) Funding $35000
Role Site Principal Investigator Title My Life Our Future (MLOF) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Trial StartEnc Date 12914-12816 Funding Direct cost $2748 Indirect cost $752
Role Co Investigator Title Hemophilia Inhibitor Research Study Ph III (HIRS) Site PI MRajpurkar MD Source Center for Disease Control Period of Support 1092014 ndash 9302015 Direct costs $20340 (based on enrollment)
Role Site Principal Investigator Title Hemophilia Foundation of MI Sponsor ATHN Trial StartEnc Date 9302014-92915 (renewed yearly) Funding $37000
Role Co Investigator Title Molecular and clinical biology of von Willebrandrsquos Disease (Zimmerman project) Source National Institutes of Science (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of Support 20114-013117 Direct Cost $16413 (Based on enrollment)
10
Active Grants and Contracts
Role Co Investigator Title Comparative Effectiveness in the Diagnosis of vWD Source National Institutes of Health (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of support 2114-13117 Direct Cost $33534 (Based on enrollment)
Role Co-Investigator Title Multicenter Evaluation of the Duration of Therapy for Thrombosis in Children Site PI MRajpurkar Source All Childrens Research Institute Inc Period of Support 01012014-12312018 Direct cost $9230
Role Site Principal Investigator Title Personalized Medicine in Hemophilia Sponsor Childrens Hospital of Los Angeles Trial StartEnc Date 7113-63016 Funding Direct cost $33041 Indirect cost $17181
Role Principal Investigator Title Regional and Cultural Variance in Perceptions Pertaining to Research Participation Sponsor None Trial StartEnd Date 0513-122015 Funding NA
Role Principal Investigator Percent Effort 20 Title Thromboelastography in Severe Hemophilia Following Clotting Factor Replacement Therapy The primary objective is to evaluate the utility of Thromboelastography in the assessment of pharmacokinetics after factor replacement in patients with severemoderately severe hemophilia Sponsor Childrens Research Center of Michigan Grant StartEnd Date 22008- 122015 (closed to enrollment Data analysis ongoing) Funding Direct cost $45910 Indirect cost 1069342
Role Site PI Title Pediatric and adult intercontinental registry on chronic ITP Sponsor University Childrenrsquos Hospital Basel Switzerland Trial StartEnd Date 404 to 62016 80 patients entered to date from our Center Funding NA
Role Co- Investigator Title A Randomized Open-Label Active Controlled Safety and Extrapolated Efficacy Study in Pediatric Subjects Requiring Anticoagulation for the Treatment of a Venous Thromboembolic Event Source Pfizer Inc
11 Period of support 612015- 5312020 Total Direct Cost $63802 (based on enrollment)
Clinical Trials Activities Role Site Principal Investigator Title Use of rFXIII in treatment of congenital FXIII deficiency a prospective multi-centre observational study- MENTOR 6 (25RGV) Sponsor Novo Nordisk Trial StartEnd Date 11515-11417 Funding $25611
Role Site Principal Investigator Title Study of Prophylaxis ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated with ADVATE or RIXUBIS (SPACE) (25RE7) Sponsor Baxter Healthcare Corp Trial startEnd Date 12914-12816 Funding Direct cost $9541 Indirect cost $2481 (based on patient enrollment)
Role Co Investigator Title Oral Rivaroxaban in children with venous thrombosis a 30 day open label active controlled randomized study of the safety efficacy and the pharmacokinetic and pharmacodynamic properties of oral rivaroxaban in children with venous thrombosis Source Bayer Corporation Period of support 062314- 04082016 Total Direct Cost 74352
Role Co Investigator Title An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune (Idiopathic) Thrombocytopenia Purpura (ITP) Site PI MCallaghan Sponsor Amgen Inc Trial StartEnd Date 032213 - 32118 Funding $130870
Role Site Principal- Investigator Title PH3 NN7088-3859 A Multi-National Trial Evaluating Safety and Efficacy Including Pharmacokinetics of NNC 0159-0000-1003 when Administered for Treatment and Prophylaxis of Bleeding in Patients with Haemophilia A - Pathfinder N8 GP (25QPY) Sponsor Novo Nordisk Trial startEnd Date 11813- 102121 Funding Direct cost $61538 Indirect cost $16000
Role Co- Primary Investigator Title Safety and Efficacy of NNC 0155-0000-0004 in Prevention and Treatment of Bleeds in Pediatric Previously Untreated Patients with Haemophilia A (Guardian) N8 PUPs Source Novo Nordisk Period of support 091212- 04082016 Total Cost $15270 (based on enrollment)
12
Clinical Trials Activities Role Co-Investigator Title Rescue Immune-tolerance Study in ITI Experienced Patients shyResist Experienced Source City of Hope Period of support 08152012-02122015 (Study is closed to accrual but following subjects enrolled) Direct Cost$ 5750
Role Co Investigator Title Single-dose pilot study of rivaroxaban in pediatric subjects with venous thromboembolism-12892 Source Bayer Corporation Site PI MRajpurkar Period of Support 061512-123115 Total Direct Cost $83961 (based on enrollment)
Role Co-investigator Title A Phase 3 Randomized Double Blind Placebo Controlled Study to Determine the Safety and Efficacy of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune Thrombocytopenia (ITP) Principal Investigator M Callaghan Sponsor Amgen Inc Trial StartEnd Date 1211-0414 Funding $56000
Role Co Investigator Title - A Three Month Prospective Open Label Study of Therapy with FRAGMINreg (Dalteparin Sodium Injection) in Children with Malignancies and Venous Thromboembolism - FRAG-A001-201 Source Easai Inc Site PI MRajpurkar Period of Support 092810 - 052115 Total Direct Cost$5285742
Role Site Principal Investigator Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (25PYE) Sponsor Novo Nordisk Inc Trial startEnd Date 22309-122115 Funding Direct cost $44005 Indirect cost $11441
Completed Studies
Role Site Principal Investigator Title Evaluate the Activity a Site Specific of BDomain Deleted (BDD) Pegylated Recombinant FVIII Protein (BAY 94-9027) in Plasma Samples Measured with both Chromogenic and One Stage Assays Sponsor Bayer Trial StartEnc Date 8115- 8116 Funding $696400
13 Completed Studies
Role Co-investigator Title Safety and Efficacy of N8 in prevention and treatment of bleeds in pediatric Previously treated patients with Hemophilia A Site PI MRajpurkar Sponsor Novo Nordisk Trial StartEnd Date 1210 to 911 Funding $381729
Role Site PI Title 3760- Phase 3b Trial Investigating the Pharmacokinetics amp Safety Profile of Single IV Dose of rFXIII in Paediatric (1 to less than 6 Years Old) Subjects with Congenital FXIII A-Subunit Deficiency Sponsor Novo Nordisk Inc Trial StartEnd Date 1110-0112 Funding $ 4315752
Role Co-investigator Title Universal data and serum specimen collection (UDC) system for hemophilia Sponsor Centers for Disease Control (CDC) Site PI JLusher Trial StartEnd Date 0610 to 511 Funding $48000
Role Site PI for multi center trial Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (N13 3720) (Mentor 2) Sponsor Novo Nordisk Inc Trial StartEnd Date 0410- 1214 Funding $ 5544504
Role Principal Investigator Title Prospective ADVATE ITI Registry (Pair) Sponsor Baxter Trial StartEnd Date 210 -411 Funding $2000
Role Co-investigator Title Mechanisms of Race Based Differences in Factor VIII Immunogenicity in Hemophilia Sponsor NIH Supleveda Site PI JLusher Trial StartEnd Date 0909 to 0911 Funding $70000
Role Co-investigator Title Treatment of Congenital Factor VII deficiency A prospective observational studySTER [Seven Deficiency Treatment Registry] Site PI MRajpurkar Sponsor Quintiles Inc Trial StartEnd Date 709 to 1210 Funding $2800
14 Completed Studies
Role Site PI for multi center trial Title Prophylaxis Patient Case Collection (PRO-PACT) Sponsor Novo Nordisk Inc Trial StartEnd Date 409-0510 Funding $3984
Role Co-investigator Title Phase 1 Prospective Randomized Crossover Study to Compare the Pharmacokinetics and Safety of rAHF-PFM Reconstituted in 2mL versus 5mL SWFI in Previously Treated Severe Hemophilia A Patients Site PI JLusher Sponsor Baxter BioScience Trial StartEnd Date 208- 310 Funding $34272
Role Consultant Title Thromboelastographic evaluation of hypercoagulability after Fontanrsquos surgery Site PI MRajpurkar Sponsor CRCM Trial StartEnd Date 706 to 1210 Funding $ 32507
Role Site PI Title Recombinant anti-hemophilic factor manufactured and formulated without added human or animal proteins (rAHF PFM) evaluation of immunogenicity efficacy and safety in previously untreated patients with hemophilia A (PUP study) Sponsor Baxter Bioscience Trial StartEnd Date 404-0909 Funding $32582
Role Co-investigator Title Chiron Gene Therapy Long Term Safety Follow-up Site PI JLusher Sponsor Chiron Corp Trial StartEnd Date 0800 to 1210 Funding $1771
PUBLICATIONS Peer-Reviewed Publications
Reports of Original Work Notes Trainee or student mentored by MC Citation data from Web of Science
1 Iorio A Keepanasseril A Foster G Navarro-Ruan T McEneny-King A Edginton AN Thabane L WAPPS-Hemo co-investigator network Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Study Protocol JMIR Res Protoc 2016 Dec 155(4)e239
2 James PD Mahlangu J Bidlingmaier C Mingot-Castellano ME Chitlur M Fogarty PF Cuker A Mancuso ME Holme PA Grabell J Satkunam N Hopman WM Mathew P Global Emerging HEmostasis Experts Panel (GEHEP) Evaluation of the utility of the ISTH-BAT in haemophilia carriers a multinational studyHaemophilia 2016 Nov22(6)912-918
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
8
Faculty (eg CME) Apr 2011 Title Treatment Decisions and Clinical Outcomes in Hemophilia B Patients With Inhibitors Credits 075 CME 10 CNE Activity Type Online CME Activity Activity Description In this vodcast learning activity Meera Chitlur MD explains the history prevalence of FIX deficiency and various treatment modalities available She also explores the possible causes for the co-manifestation of inhibitor development and allergic reactions and the usefulness of registries in monitoring the occurrence of inhibitors in patients with hemophilia B
Aug 2010 Global Assays in Hemostasis Invited speaker for Grand Rounds atDevaraj Urs Medical College Kolar Karnataka India
Aug 2009 Title FIX Deficiency and Inhibitors Report From the ISTH-SSC International Registry Credits 075 CME 10 CNE Activity Type Online CME ActivityActivity Description The advent of registry databases to aid collection ofinformation on hemophilia B has helped further the understanding of FIXdeficiency and inhibitors within the scientific community In this learningactivity Meera Chitlur MD discusses the importance of the ISTH-SSCInternational FIX Inhibitor Registry in addition to etiology of severe reactions associated with appearance of inhibitors in hemophilia B
Mentorship 2008DrShilpa Jain MD Mentored research project entitled ldquoThrombin generationin children with moderate to severe hemophiliardquo with year III Pediatric Resident Dr S Jain who was awarded first place in the Resident Research Competition 2009DrBMehta PGY2 mentor for research project on thrombin generation inpatients on Ventricular Assist Devicersquos 2009 2009-2011 Dr S Veluswamy Mentor to PGY3 resident 2012-2014 DrAbdullah Mentor to PGY2 resident 2012-2013 DrsAyesha Zia MD Fellow Mentor for fellow projects 2010-2013 DrLRao MD Fellow Clinical and Research Mentor 2013-2015 DrTSarkar Fellow Research mentor 2005Visiting professorscientists DrDSosothikul from Thailand 2007-2008
DrAlphan Kupesiz from Turkey May 2013 DrMaissaa Janbain MD Tulane University Externship mentor April 2013 Dr Indrayas Woldie MD Karmanos Cancer Institute WSU May2015 DrJing Christine Ye MD Karmanos Cancer Institute WSU July 2015 Dr Yasmina Abajas University of North Carolina Global Assays Training 2016-2017 Dr Katherine Regling PGY2-3 2016-2018 DrBettina Joi Isaac Fellow Research mentor 2016-2018 DrSarah Ramiz Fellow Research mentor
GRANTS CONTRACTS AND OTHER FUNDING
Active Grants and Contracts Role Site Principal Investigator Title Cascade Hemophilia Consortium Grant Sponsor Cascade Hemophilia Consortium
9 Trial StartEnc Date 6115-53116 (renewed yearly) Funding $221161
Active Grants and Contracts Role Site Principal Investigator Title My Life Our Future (MLOF2) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Period of Support 1115-123115 Funding Direct cost $1468 Indirect cost $38
Role Site Principal Investigator Title Validation of the ISTH-BAT (International Society on Thrombosis and Haemostasis Bleeding Assessment Tool) in Hemophilia Carriers Sponsor Queenrsquos University Grant StartEnd Date 32014-12016 Funding Direct cost $5750 Indirect cost $910
Role Site Principal Investigator Title Maternal and Child Health Bureau (MCHB) Comprehensive Care Sponsor Maternal and Child Health Bureau Grant StartEnd date 2014-2015 (renewed yearly) Funding $35000
Role Site Principal Investigator Title My Life Our Future (MLOF) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Trial StartEnc Date 12914-12816 Funding Direct cost $2748 Indirect cost $752
Role Co Investigator Title Hemophilia Inhibitor Research Study Ph III (HIRS) Site PI MRajpurkar MD Source Center for Disease Control Period of Support 1092014 ndash 9302015 Direct costs $20340 (based on enrollment)
Role Site Principal Investigator Title Hemophilia Foundation of MI Sponsor ATHN Trial StartEnc Date 9302014-92915 (renewed yearly) Funding $37000
Role Co Investigator Title Molecular and clinical biology of von Willebrandrsquos Disease (Zimmerman project) Source National Institutes of Science (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of Support 20114-013117 Direct Cost $16413 (Based on enrollment)
10
Active Grants and Contracts
Role Co Investigator Title Comparative Effectiveness in the Diagnosis of vWD Source National Institutes of Health (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of support 2114-13117 Direct Cost $33534 (Based on enrollment)
Role Co-Investigator Title Multicenter Evaluation of the Duration of Therapy for Thrombosis in Children Site PI MRajpurkar Source All Childrens Research Institute Inc Period of Support 01012014-12312018 Direct cost $9230
Role Site Principal Investigator Title Personalized Medicine in Hemophilia Sponsor Childrens Hospital of Los Angeles Trial StartEnc Date 7113-63016 Funding Direct cost $33041 Indirect cost $17181
Role Principal Investigator Title Regional and Cultural Variance in Perceptions Pertaining to Research Participation Sponsor None Trial StartEnd Date 0513-122015 Funding NA
Role Principal Investigator Percent Effort 20 Title Thromboelastography in Severe Hemophilia Following Clotting Factor Replacement Therapy The primary objective is to evaluate the utility of Thromboelastography in the assessment of pharmacokinetics after factor replacement in patients with severemoderately severe hemophilia Sponsor Childrens Research Center of Michigan Grant StartEnd Date 22008- 122015 (closed to enrollment Data analysis ongoing) Funding Direct cost $45910 Indirect cost 1069342
Role Site PI Title Pediatric and adult intercontinental registry on chronic ITP Sponsor University Childrenrsquos Hospital Basel Switzerland Trial StartEnd Date 404 to 62016 80 patients entered to date from our Center Funding NA
Role Co- Investigator Title A Randomized Open-Label Active Controlled Safety and Extrapolated Efficacy Study in Pediatric Subjects Requiring Anticoagulation for the Treatment of a Venous Thromboembolic Event Source Pfizer Inc
11 Period of support 612015- 5312020 Total Direct Cost $63802 (based on enrollment)
Clinical Trials Activities Role Site Principal Investigator Title Use of rFXIII in treatment of congenital FXIII deficiency a prospective multi-centre observational study- MENTOR 6 (25RGV) Sponsor Novo Nordisk Trial StartEnd Date 11515-11417 Funding $25611
Role Site Principal Investigator Title Study of Prophylaxis ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated with ADVATE or RIXUBIS (SPACE) (25RE7) Sponsor Baxter Healthcare Corp Trial startEnd Date 12914-12816 Funding Direct cost $9541 Indirect cost $2481 (based on patient enrollment)
Role Co Investigator Title Oral Rivaroxaban in children with venous thrombosis a 30 day open label active controlled randomized study of the safety efficacy and the pharmacokinetic and pharmacodynamic properties of oral rivaroxaban in children with venous thrombosis Source Bayer Corporation Period of support 062314- 04082016 Total Direct Cost 74352
Role Co Investigator Title An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune (Idiopathic) Thrombocytopenia Purpura (ITP) Site PI MCallaghan Sponsor Amgen Inc Trial StartEnd Date 032213 - 32118 Funding $130870
Role Site Principal- Investigator Title PH3 NN7088-3859 A Multi-National Trial Evaluating Safety and Efficacy Including Pharmacokinetics of NNC 0159-0000-1003 when Administered for Treatment and Prophylaxis of Bleeding in Patients with Haemophilia A - Pathfinder N8 GP (25QPY) Sponsor Novo Nordisk Trial startEnd Date 11813- 102121 Funding Direct cost $61538 Indirect cost $16000
Role Co- Primary Investigator Title Safety and Efficacy of NNC 0155-0000-0004 in Prevention and Treatment of Bleeds in Pediatric Previously Untreated Patients with Haemophilia A (Guardian) N8 PUPs Source Novo Nordisk Period of support 091212- 04082016 Total Cost $15270 (based on enrollment)
12
Clinical Trials Activities Role Co-Investigator Title Rescue Immune-tolerance Study in ITI Experienced Patients shyResist Experienced Source City of Hope Period of support 08152012-02122015 (Study is closed to accrual but following subjects enrolled) Direct Cost$ 5750
Role Co Investigator Title Single-dose pilot study of rivaroxaban in pediatric subjects with venous thromboembolism-12892 Source Bayer Corporation Site PI MRajpurkar Period of Support 061512-123115 Total Direct Cost $83961 (based on enrollment)
Role Co-investigator Title A Phase 3 Randomized Double Blind Placebo Controlled Study to Determine the Safety and Efficacy of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune Thrombocytopenia (ITP) Principal Investigator M Callaghan Sponsor Amgen Inc Trial StartEnd Date 1211-0414 Funding $56000
Role Co Investigator Title - A Three Month Prospective Open Label Study of Therapy with FRAGMINreg (Dalteparin Sodium Injection) in Children with Malignancies and Venous Thromboembolism - FRAG-A001-201 Source Easai Inc Site PI MRajpurkar Period of Support 092810 - 052115 Total Direct Cost$5285742
Role Site Principal Investigator Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (25PYE) Sponsor Novo Nordisk Inc Trial startEnd Date 22309-122115 Funding Direct cost $44005 Indirect cost $11441
Completed Studies
Role Site Principal Investigator Title Evaluate the Activity a Site Specific of BDomain Deleted (BDD) Pegylated Recombinant FVIII Protein (BAY 94-9027) in Plasma Samples Measured with both Chromogenic and One Stage Assays Sponsor Bayer Trial StartEnc Date 8115- 8116 Funding $696400
13 Completed Studies
Role Co-investigator Title Safety and Efficacy of N8 in prevention and treatment of bleeds in pediatric Previously treated patients with Hemophilia A Site PI MRajpurkar Sponsor Novo Nordisk Trial StartEnd Date 1210 to 911 Funding $381729
Role Site PI Title 3760- Phase 3b Trial Investigating the Pharmacokinetics amp Safety Profile of Single IV Dose of rFXIII in Paediatric (1 to less than 6 Years Old) Subjects with Congenital FXIII A-Subunit Deficiency Sponsor Novo Nordisk Inc Trial StartEnd Date 1110-0112 Funding $ 4315752
Role Co-investigator Title Universal data and serum specimen collection (UDC) system for hemophilia Sponsor Centers for Disease Control (CDC) Site PI JLusher Trial StartEnd Date 0610 to 511 Funding $48000
Role Site PI for multi center trial Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (N13 3720) (Mentor 2) Sponsor Novo Nordisk Inc Trial StartEnd Date 0410- 1214 Funding $ 5544504
Role Principal Investigator Title Prospective ADVATE ITI Registry (Pair) Sponsor Baxter Trial StartEnd Date 210 -411 Funding $2000
Role Co-investigator Title Mechanisms of Race Based Differences in Factor VIII Immunogenicity in Hemophilia Sponsor NIH Supleveda Site PI JLusher Trial StartEnd Date 0909 to 0911 Funding $70000
Role Co-investigator Title Treatment of Congenital Factor VII deficiency A prospective observational studySTER [Seven Deficiency Treatment Registry] Site PI MRajpurkar Sponsor Quintiles Inc Trial StartEnd Date 709 to 1210 Funding $2800
14 Completed Studies
Role Site PI for multi center trial Title Prophylaxis Patient Case Collection (PRO-PACT) Sponsor Novo Nordisk Inc Trial StartEnd Date 409-0510 Funding $3984
Role Co-investigator Title Phase 1 Prospective Randomized Crossover Study to Compare the Pharmacokinetics and Safety of rAHF-PFM Reconstituted in 2mL versus 5mL SWFI in Previously Treated Severe Hemophilia A Patients Site PI JLusher Sponsor Baxter BioScience Trial StartEnd Date 208- 310 Funding $34272
Role Consultant Title Thromboelastographic evaluation of hypercoagulability after Fontanrsquos surgery Site PI MRajpurkar Sponsor CRCM Trial StartEnd Date 706 to 1210 Funding $ 32507
Role Site PI Title Recombinant anti-hemophilic factor manufactured and formulated without added human or animal proteins (rAHF PFM) evaluation of immunogenicity efficacy and safety in previously untreated patients with hemophilia A (PUP study) Sponsor Baxter Bioscience Trial StartEnd Date 404-0909 Funding $32582
Role Co-investigator Title Chiron Gene Therapy Long Term Safety Follow-up Site PI JLusher Sponsor Chiron Corp Trial StartEnd Date 0800 to 1210 Funding $1771
PUBLICATIONS Peer-Reviewed Publications
Reports of Original Work Notes Trainee or student mentored by MC Citation data from Web of Science
1 Iorio A Keepanasseril A Foster G Navarro-Ruan T McEneny-King A Edginton AN Thabane L WAPPS-Hemo co-investigator network Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Study Protocol JMIR Res Protoc 2016 Dec 155(4)e239
2 James PD Mahlangu J Bidlingmaier C Mingot-Castellano ME Chitlur M Fogarty PF Cuker A Mancuso ME Holme PA Grabell J Satkunam N Hopman WM Mathew P Global Emerging HEmostasis Experts Panel (GEHEP) Evaluation of the utility of the ISTH-BAT in haemophilia carriers a multinational studyHaemophilia 2016 Nov22(6)912-918
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
9 Trial StartEnc Date 6115-53116 (renewed yearly) Funding $221161
Active Grants and Contracts Role Site Principal Investigator Title My Life Our Future (MLOF2) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Period of Support 1115-123115 Funding Direct cost $1468 Indirect cost $38
Role Site Principal Investigator Title Validation of the ISTH-BAT (International Society on Thrombosis and Haemostasis Bleeding Assessment Tool) in Hemophilia Carriers Sponsor Queenrsquos University Grant StartEnd Date 32014-12016 Funding Direct cost $5750 Indirect cost $910
Role Site Principal Investigator Title Maternal and Child Health Bureau (MCHB) Comprehensive Care Sponsor Maternal and Child Health Bureau Grant StartEnd date 2014-2015 (renewed yearly) Funding $35000
Role Site Principal Investigator Title My Life Our Future (MLOF) A Hemophilia Genotyping Initiative Data and Sample Research Repository Sponsor ATHN Trial StartEnc Date 12914-12816 Funding Direct cost $2748 Indirect cost $752
Role Co Investigator Title Hemophilia Inhibitor Research Study Ph III (HIRS) Site PI MRajpurkar MD Source Center for Disease Control Period of Support 1092014 ndash 9302015 Direct costs $20340 (based on enrollment)
Role Site Principal Investigator Title Hemophilia Foundation of MI Sponsor ATHN Trial StartEnc Date 9302014-92915 (renewed yearly) Funding $37000
Role Co Investigator Title Molecular and clinical biology of von Willebrandrsquos Disease (Zimmerman project) Source National Institutes of Science (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of Support 20114-013117 Direct Cost $16413 (Based on enrollment)
10
Active Grants and Contracts
Role Co Investigator Title Comparative Effectiveness in the Diagnosis of vWD Source National Institutes of Health (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of support 2114-13117 Direct Cost $33534 (Based on enrollment)
Role Co-Investigator Title Multicenter Evaluation of the Duration of Therapy for Thrombosis in Children Site PI MRajpurkar Source All Childrens Research Institute Inc Period of Support 01012014-12312018 Direct cost $9230
Role Site Principal Investigator Title Personalized Medicine in Hemophilia Sponsor Childrens Hospital of Los Angeles Trial StartEnc Date 7113-63016 Funding Direct cost $33041 Indirect cost $17181
Role Principal Investigator Title Regional and Cultural Variance in Perceptions Pertaining to Research Participation Sponsor None Trial StartEnd Date 0513-122015 Funding NA
Role Principal Investigator Percent Effort 20 Title Thromboelastography in Severe Hemophilia Following Clotting Factor Replacement Therapy The primary objective is to evaluate the utility of Thromboelastography in the assessment of pharmacokinetics after factor replacement in patients with severemoderately severe hemophilia Sponsor Childrens Research Center of Michigan Grant StartEnd Date 22008- 122015 (closed to enrollment Data analysis ongoing) Funding Direct cost $45910 Indirect cost 1069342
Role Site PI Title Pediatric and adult intercontinental registry on chronic ITP Sponsor University Childrenrsquos Hospital Basel Switzerland Trial StartEnd Date 404 to 62016 80 patients entered to date from our Center Funding NA
Role Co- Investigator Title A Randomized Open-Label Active Controlled Safety and Extrapolated Efficacy Study in Pediatric Subjects Requiring Anticoagulation for the Treatment of a Venous Thromboembolic Event Source Pfizer Inc
11 Period of support 612015- 5312020 Total Direct Cost $63802 (based on enrollment)
Clinical Trials Activities Role Site Principal Investigator Title Use of rFXIII in treatment of congenital FXIII deficiency a prospective multi-centre observational study- MENTOR 6 (25RGV) Sponsor Novo Nordisk Trial StartEnd Date 11515-11417 Funding $25611
Role Site Principal Investigator Title Study of Prophylaxis ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated with ADVATE or RIXUBIS (SPACE) (25RE7) Sponsor Baxter Healthcare Corp Trial startEnd Date 12914-12816 Funding Direct cost $9541 Indirect cost $2481 (based on patient enrollment)
Role Co Investigator Title Oral Rivaroxaban in children with venous thrombosis a 30 day open label active controlled randomized study of the safety efficacy and the pharmacokinetic and pharmacodynamic properties of oral rivaroxaban in children with venous thrombosis Source Bayer Corporation Period of support 062314- 04082016 Total Direct Cost 74352
Role Co Investigator Title An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune (Idiopathic) Thrombocytopenia Purpura (ITP) Site PI MCallaghan Sponsor Amgen Inc Trial StartEnd Date 032213 - 32118 Funding $130870
Role Site Principal- Investigator Title PH3 NN7088-3859 A Multi-National Trial Evaluating Safety and Efficacy Including Pharmacokinetics of NNC 0159-0000-1003 when Administered for Treatment and Prophylaxis of Bleeding in Patients with Haemophilia A - Pathfinder N8 GP (25QPY) Sponsor Novo Nordisk Trial startEnd Date 11813- 102121 Funding Direct cost $61538 Indirect cost $16000
Role Co- Primary Investigator Title Safety and Efficacy of NNC 0155-0000-0004 in Prevention and Treatment of Bleeds in Pediatric Previously Untreated Patients with Haemophilia A (Guardian) N8 PUPs Source Novo Nordisk Period of support 091212- 04082016 Total Cost $15270 (based on enrollment)
12
Clinical Trials Activities Role Co-Investigator Title Rescue Immune-tolerance Study in ITI Experienced Patients shyResist Experienced Source City of Hope Period of support 08152012-02122015 (Study is closed to accrual but following subjects enrolled) Direct Cost$ 5750
Role Co Investigator Title Single-dose pilot study of rivaroxaban in pediatric subjects with venous thromboembolism-12892 Source Bayer Corporation Site PI MRajpurkar Period of Support 061512-123115 Total Direct Cost $83961 (based on enrollment)
Role Co-investigator Title A Phase 3 Randomized Double Blind Placebo Controlled Study to Determine the Safety and Efficacy of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune Thrombocytopenia (ITP) Principal Investigator M Callaghan Sponsor Amgen Inc Trial StartEnd Date 1211-0414 Funding $56000
Role Co Investigator Title - A Three Month Prospective Open Label Study of Therapy with FRAGMINreg (Dalteparin Sodium Injection) in Children with Malignancies and Venous Thromboembolism - FRAG-A001-201 Source Easai Inc Site PI MRajpurkar Period of Support 092810 - 052115 Total Direct Cost$5285742
Role Site Principal Investigator Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (25PYE) Sponsor Novo Nordisk Inc Trial startEnd Date 22309-122115 Funding Direct cost $44005 Indirect cost $11441
Completed Studies
Role Site Principal Investigator Title Evaluate the Activity a Site Specific of BDomain Deleted (BDD) Pegylated Recombinant FVIII Protein (BAY 94-9027) in Plasma Samples Measured with both Chromogenic and One Stage Assays Sponsor Bayer Trial StartEnc Date 8115- 8116 Funding $696400
13 Completed Studies
Role Co-investigator Title Safety and Efficacy of N8 in prevention and treatment of bleeds in pediatric Previously treated patients with Hemophilia A Site PI MRajpurkar Sponsor Novo Nordisk Trial StartEnd Date 1210 to 911 Funding $381729
Role Site PI Title 3760- Phase 3b Trial Investigating the Pharmacokinetics amp Safety Profile of Single IV Dose of rFXIII in Paediatric (1 to less than 6 Years Old) Subjects with Congenital FXIII A-Subunit Deficiency Sponsor Novo Nordisk Inc Trial StartEnd Date 1110-0112 Funding $ 4315752
Role Co-investigator Title Universal data and serum specimen collection (UDC) system for hemophilia Sponsor Centers for Disease Control (CDC) Site PI JLusher Trial StartEnd Date 0610 to 511 Funding $48000
Role Site PI for multi center trial Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (N13 3720) (Mentor 2) Sponsor Novo Nordisk Inc Trial StartEnd Date 0410- 1214 Funding $ 5544504
Role Principal Investigator Title Prospective ADVATE ITI Registry (Pair) Sponsor Baxter Trial StartEnd Date 210 -411 Funding $2000
Role Co-investigator Title Mechanisms of Race Based Differences in Factor VIII Immunogenicity in Hemophilia Sponsor NIH Supleveda Site PI JLusher Trial StartEnd Date 0909 to 0911 Funding $70000
Role Co-investigator Title Treatment of Congenital Factor VII deficiency A prospective observational studySTER [Seven Deficiency Treatment Registry] Site PI MRajpurkar Sponsor Quintiles Inc Trial StartEnd Date 709 to 1210 Funding $2800
14 Completed Studies
Role Site PI for multi center trial Title Prophylaxis Patient Case Collection (PRO-PACT) Sponsor Novo Nordisk Inc Trial StartEnd Date 409-0510 Funding $3984
Role Co-investigator Title Phase 1 Prospective Randomized Crossover Study to Compare the Pharmacokinetics and Safety of rAHF-PFM Reconstituted in 2mL versus 5mL SWFI in Previously Treated Severe Hemophilia A Patients Site PI JLusher Sponsor Baxter BioScience Trial StartEnd Date 208- 310 Funding $34272
Role Consultant Title Thromboelastographic evaluation of hypercoagulability after Fontanrsquos surgery Site PI MRajpurkar Sponsor CRCM Trial StartEnd Date 706 to 1210 Funding $ 32507
Role Site PI Title Recombinant anti-hemophilic factor manufactured and formulated without added human or animal proteins (rAHF PFM) evaluation of immunogenicity efficacy and safety in previously untreated patients with hemophilia A (PUP study) Sponsor Baxter Bioscience Trial StartEnd Date 404-0909 Funding $32582
Role Co-investigator Title Chiron Gene Therapy Long Term Safety Follow-up Site PI JLusher Sponsor Chiron Corp Trial StartEnd Date 0800 to 1210 Funding $1771
PUBLICATIONS Peer-Reviewed Publications
Reports of Original Work Notes Trainee or student mentored by MC Citation data from Web of Science
1 Iorio A Keepanasseril A Foster G Navarro-Ruan T McEneny-King A Edginton AN Thabane L WAPPS-Hemo co-investigator network Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Study Protocol JMIR Res Protoc 2016 Dec 155(4)e239
2 James PD Mahlangu J Bidlingmaier C Mingot-Castellano ME Chitlur M Fogarty PF Cuker A Mancuso ME Holme PA Grabell J Satkunam N Hopman WM Mathew P Global Emerging HEmostasis Experts Panel (GEHEP) Evaluation of the utility of the ISTH-BAT in haemophilia carriers a multinational studyHaemophilia 2016 Nov22(6)912-918
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
10
Active Grants and Contracts
Role Co Investigator Title Comparative Effectiveness in the Diagnosis of vWD Source National Institutes of Health (University of Wisconsin) Multicenter RO1 Site PI MRajpurkar Period of support 2114-13117 Direct Cost $33534 (Based on enrollment)
Role Co-Investigator Title Multicenter Evaluation of the Duration of Therapy for Thrombosis in Children Site PI MRajpurkar Source All Childrens Research Institute Inc Period of Support 01012014-12312018 Direct cost $9230
Role Site Principal Investigator Title Personalized Medicine in Hemophilia Sponsor Childrens Hospital of Los Angeles Trial StartEnc Date 7113-63016 Funding Direct cost $33041 Indirect cost $17181
Role Principal Investigator Title Regional and Cultural Variance in Perceptions Pertaining to Research Participation Sponsor None Trial StartEnd Date 0513-122015 Funding NA
Role Principal Investigator Percent Effort 20 Title Thromboelastography in Severe Hemophilia Following Clotting Factor Replacement Therapy The primary objective is to evaluate the utility of Thromboelastography in the assessment of pharmacokinetics after factor replacement in patients with severemoderately severe hemophilia Sponsor Childrens Research Center of Michigan Grant StartEnd Date 22008- 122015 (closed to enrollment Data analysis ongoing) Funding Direct cost $45910 Indirect cost 1069342
Role Site PI Title Pediatric and adult intercontinental registry on chronic ITP Sponsor University Childrenrsquos Hospital Basel Switzerland Trial StartEnd Date 404 to 62016 80 patients entered to date from our Center Funding NA
Role Co- Investigator Title A Randomized Open-Label Active Controlled Safety and Extrapolated Efficacy Study in Pediatric Subjects Requiring Anticoagulation for the Treatment of a Venous Thromboembolic Event Source Pfizer Inc
11 Period of support 612015- 5312020 Total Direct Cost $63802 (based on enrollment)
Clinical Trials Activities Role Site Principal Investigator Title Use of rFXIII in treatment of congenital FXIII deficiency a prospective multi-centre observational study- MENTOR 6 (25RGV) Sponsor Novo Nordisk Trial StartEnd Date 11515-11417 Funding $25611
Role Site Principal Investigator Title Study of Prophylaxis ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated with ADVATE or RIXUBIS (SPACE) (25RE7) Sponsor Baxter Healthcare Corp Trial startEnd Date 12914-12816 Funding Direct cost $9541 Indirect cost $2481 (based on patient enrollment)
Role Co Investigator Title Oral Rivaroxaban in children with venous thrombosis a 30 day open label active controlled randomized study of the safety efficacy and the pharmacokinetic and pharmacodynamic properties of oral rivaroxaban in children with venous thrombosis Source Bayer Corporation Period of support 062314- 04082016 Total Direct Cost 74352
Role Co Investigator Title An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune (Idiopathic) Thrombocytopenia Purpura (ITP) Site PI MCallaghan Sponsor Amgen Inc Trial StartEnd Date 032213 - 32118 Funding $130870
Role Site Principal- Investigator Title PH3 NN7088-3859 A Multi-National Trial Evaluating Safety and Efficacy Including Pharmacokinetics of NNC 0159-0000-1003 when Administered for Treatment and Prophylaxis of Bleeding in Patients with Haemophilia A - Pathfinder N8 GP (25QPY) Sponsor Novo Nordisk Trial startEnd Date 11813- 102121 Funding Direct cost $61538 Indirect cost $16000
Role Co- Primary Investigator Title Safety and Efficacy of NNC 0155-0000-0004 in Prevention and Treatment of Bleeds in Pediatric Previously Untreated Patients with Haemophilia A (Guardian) N8 PUPs Source Novo Nordisk Period of support 091212- 04082016 Total Cost $15270 (based on enrollment)
12
Clinical Trials Activities Role Co-Investigator Title Rescue Immune-tolerance Study in ITI Experienced Patients shyResist Experienced Source City of Hope Period of support 08152012-02122015 (Study is closed to accrual but following subjects enrolled) Direct Cost$ 5750
Role Co Investigator Title Single-dose pilot study of rivaroxaban in pediatric subjects with venous thromboembolism-12892 Source Bayer Corporation Site PI MRajpurkar Period of Support 061512-123115 Total Direct Cost $83961 (based on enrollment)
Role Co-investigator Title A Phase 3 Randomized Double Blind Placebo Controlled Study to Determine the Safety and Efficacy of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune Thrombocytopenia (ITP) Principal Investigator M Callaghan Sponsor Amgen Inc Trial StartEnd Date 1211-0414 Funding $56000
Role Co Investigator Title - A Three Month Prospective Open Label Study of Therapy with FRAGMINreg (Dalteparin Sodium Injection) in Children with Malignancies and Venous Thromboembolism - FRAG-A001-201 Source Easai Inc Site PI MRajpurkar Period of Support 092810 - 052115 Total Direct Cost$5285742
Role Site Principal Investigator Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (25PYE) Sponsor Novo Nordisk Inc Trial startEnd Date 22309-122115 Funding Direct cost $44005 Indirect cost $11441
Completed Studies
Role Site Principal Investigator Title Evaluate the Activity a Site Specific of BDomain Deleted (BDD) Pegylated Recombinant FVIII Protein (BAY 94-9027) in Plasma Samples Measured with both Chromogenic and One Stage Assays Sponsor Bayer Trial StartEnc Date 8115- 8116 Funding $696400
13 Completed Studies
Role Co-investigator Title Safety and Efficacy of N8 in prevention and treatment of bleeds in pediatric Previously treated patients with Hemophilia A Site PI MRajpurkar Sponsor Novo Nordisk Trial StartEnd Date 1210 to 911 Funding $381729
Role Site PI Title 3760- Phase 3b Trial Investigating the Pharmacokinetics amp Safety Profile of Single IV Dose of rFXIII in Paediatric (1 to less than 6 Years Old) Subjects with Congenital FXIII A-Subunit Deficiency Sponsor Novo Nordisk Inc Trial StartEnd Date 1110-0112 Funding $ 4315752
Role Co-investigator Title Universal data and serum specimen collection (UDC) system for hemophilia Sponsor Centers for Disease Control (CDC) Site PI JLusher Trial StartEnd Date 0610 to 511 Funding $48000
Role Site PI for multi center trial Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (N13 3720) (Mentor 2) Sponsor Novo Nordisk Inc Trial StartEnd Date 0410- 1214 Funding $ 5544504
Role Principal Investigator Title Prospective ADVATE ITI Registry (Pair) Sponsor Baxter Trial StartEnd Date 210 -411 Funding $2000
Role Co-investigator Title Mechanisms of Race Based Differences in Factor VIII Immunogenicity in Hemophilia Sponsor NIH Supleveda Site PI JLusher Trial StartEnd Date 0909 to 0911 Funding $70000
Role Co-investigator Title Treatment of Congenital Factor VII deficiency A prospective observational studySTER [Seven Deficiency Treatment Registry] Site PI MRajpurkar Sponsor Quintiles Inc Trial StartEnd Date 709 to 1210 Funding $2800
14 Completed Studies
Role Site PI for multi center trial Title Prophylaxis Patient Case Collection (PRO-PACT) Sponsor Novo Nordisk Inc Trial StartEnd Date 409-0510 Funding $3984
Role Co-investigator Title Phase 1 Prospective Randomized Crossover Study to Compare the Pharmacokinetics and Safety of rAHF-PFM Reconstituted in 2mL versus 5mL SWFI in Previously Treated Severe Hemophilia A Patients Site PI JLusher Sponsor Baxter BioScience Trial StartEnd Date 208- 310 Funding $34272
Role Consultant Title Thromboelastographic evaluation of hypercoagulability after Fontanrsquos surgery Site PI MRajpurkar Sponsor CRCM Trial StartEnd Date 706 to 1210 Funding $ 32507
Role Site PI Title Recombinant anti-hemophilic factor manufactured and formulated without added human or animal proteins (rAHF PFM) evaluation of immunogenicity efficacy and safety in previously untreated patients with hemophilia A (PUP study) Sponsor Baxter Bioscience Trial StartEnd Date 404-0909 Funding $32582
Role Co-investigator Title Chiron Gene Therapy Long Term Safety Follow-up Site PI JLusher Sponsor Chiron Corp Trial StartEnd Date 0800 to 1210 Funding $1771
PUBLICATIONS Peer-Reviewed Publications
Reports of Original Work Notes Trainee or student mentored by MC Citation data from Web of Science
1 Iorio A Keepanasseril A Foster G Navarro-Ruan T McEneny-King A Edginton AN Thabane L WAPPS-Hemo co-investigator network Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Study Protocol JMIR Res Protoc 2016 Dec 155(4)e239
2 James PD Mahlangu J Bidlingmaier C Mingot-Castellano ME Chitlur M Fogarty PF Cuker A Mancuso ME Holme PA Grabell J Satkunam N Hopman WM Mathew P Global Emerging HEmostasis Experts Panel (GEHEP) Evaluation of the utility of the ISTH-BAT in haemophilia carriers a multinational studyHaemophilia 2016 Nov22(6)912-918
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
11 Period of support 612015- 5312020 Total Direct Cost $63802 (based on enrollment)
Clinical Trials Activities Role Site Principal Investigator Title Use of rFXIII in treatment of congenital FXIII deficiency a prospective multi-centre observational study- MENTOR 6 (25RGV) Sponsor Novo Nordisk Trial StartEnd Date 11515-11417 Funding $25611
Role Site Principal Investigator Title Study of Prophylaxis ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated with ADVATE or RIXUBIS (SPACE) (25RE7) Sponsor Baxter Healthcare Corp Trial startEnd Date 12914-12816 Funding Direct cost $9541 Indirect cost $2481 (based on patient enrollment)
Role Co Investigator Title Oral Rivaroxaban in children with venous thrombosis a 30 day open label active controlled randomized study of the safety efficacy and the pharmacokinetic and pharmacodynamic properties of oral rivaroxaban in children with venous thrombosis Source Bayer Corporation Period of support 062314- 04082016 Total Direct Cost 74352
Role Co Investigator Title An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune (Idiopathic) Thrombocytopenia Purpura (ITP) Site PI MCallaghan Sponsor Amgen Inc Trial StartEnd Date 032213 - 32118 Funding $130870
Role Site Principal- Investigator Title PH3 NN7088-3859 A Multi-National Trial Evaluating Safety and Efficacy Including Pharmacokinetics of NNC 0159-0000-1003 when Administered for Treatment and Prophylaxis of Bleeding in Patients with Haemophilia A - Pathfinder N8 GP (25QPY) Sponsor Novo Nordisk Trial startEnd Date 11813- 102121 Funding Direct cost $61538 Indirect cost $16000
Role Co- Primary Investigator Title Safety and Efficacy of NNC 0155-0000-0004 in Prevention and Treatment of Bleeds in Pediatric Previously Untreated Patients with Haemophilia A (Guardian) N8 PUPs Source Novo Nordisk Period of support 091212- 04082016 Total Cost $15270 (based on enrollment)
12
Clinical Trials Activities Role Co-Investigator Title Rescue Immune-tolerance Study in ITI Experienced Patients shyResist Experienced Source City of Hope Period of support 08152012-02122015 (Study is closed to accrual but following subjects enrolled) Direct Cost$ 5750
Role Co Investigator Title Single-dose pilot study of rivaroxaban in pediatric subjects with venous thromboembolism-12892 Source Bayer Corporation Site PI MRajpurkar Period of Support 061512-123115 Total Direct Cost $83961 (based on enrollment)
Role Co-investigator Title A Phase 3 Randomized Double Blind Placebo Controlled Study to Determine the Safety and Efficacy of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune Thrombocytopenia (ITP) Principal Investigator M Callaghan Sponsor Amgen Inc Trial StartEnd Date 1211-0414 Funding $56000
Role Co Investigator Title - A Three Month Prospective Open Label Study of Therapy with FRAGMINreg (Dalteparin Sodium Injection) in Children with Malignancies and Venous Thromboembolism - FRAG-A001-201 Source Easai Inc Site PI MRajpurkar Period of Support 092810 - 052115 Total Direct Cost$5285742
Role Site Principal Investigator Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (25PYE) Sponsor Novo Nordisk Inc Trial startEnd Date 22309-122115 Funding Direct cost $44005 Indirect cost $11441
Completed Studies
Role Site Principal Investigator Title Evaluate the Activity a Site Specific of BDomain Deleted (BDD) Pegylated Recombinant FVIII Protein (BAY 94-9027) in Plasma Samples Measured with both Chromogenic and One Stage Assays Sponsor Bayer Trial StartEnc Date 8115- 8116 Funding $696400
13 Completed Studies
Role Co-investigator Title Safety and Efficacy of N8 in prevention and treatment of bleeds in pediatric Previously treated patients with Hemophilia A Site PI MRajpurkar Sponsor Novo Nordisk Trial StartEnd Date 1210 to 911 Funding $381729
Role Site PI Title 3760- Phase 3b Trial Investigating the Pharmacokinetics amp Safety Profile of Single IV Dose of rFXIII in Paediatric (1 to less than 6 Years Old) Subjects with Congenital FXIII A-Subunit Deficiency Sponsor Novo Nordisk Inc Trial StartEnd Date 1110-0112 Funding $ 4315752
Role Co-investigator Title Universal data and serum specimen collection (UDC) system for hemophilia Sponsor Centers for Disease Control (CDC) Site PI JLusher Trial StartEnd Date 0610 to 511 Funding $48000
Role Site PI for multi center trial Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (N13 3720) (Mentor 2) Sponsor Novo Nordisk Inc Trial StartEnd Date 0410- 1214 Funding $ 5544504
Role Principal Investigator Title Prospective ADVATE ITI Registry (Pair) Sponsor Baxter Trial StartEnd Date 210 -411 Funding $2000
Role Co-investigator Title Mechanisms of Race Based Differences in Factor VIII Immunogenicity in Hemophilia Sponsor NIH Supleveda Site PI JLusher Trial StartEnd Date 0909 to 0911 Funding $70000
Role Co-investigator Title Treatment of Congenital Factor VII deficiency A prospective observational studySTER [Seven Deficiency Treatment Registry] Site PI MRajpurkar Sponsor Quintiles Inc Trial StartEnd Date 709 to 1210 Funding $2800
14 Completed Studies
Role Site PI for multi center trial Title Prophylaxis Patient Case Collection (PRO-PACT) Sponsor Novo Nordisk Inc Trial StartEnd Date 409-0510 Funding $3984
Role Co-investigator Title Phase 1 Prospective Randomized Crossover Study to Compare the Pharmacokinetics and Safety of rAHF-PFM Reconstituted in 2mL versus 5mL SWFI in Previously Treated Severe Hemophilia A Patients Site PI JLusher Sponsor Baxter BioScience Trial StartEnd Date 208- 310 Funding $34272
Role Consultant Title Thromboelastographic evaluation of hypercoagulability after Fontanrsquos surgery Site PI MRajpurkar Sponsor CRCM Trial StartEnd Date 706 to 1210 Funding $ 32507
Role Site PI Title Recombinant anti-hemophilic factor manufactured and formulated without added human or animal proteins (rAHF PFM) evaluation of immunogenicity efficacy and safety in previously untreated patients with hemophilia A (PUP study) Sponsor Baxter Bioscience Trial StartEnd Date 404-0909 Funding $32582
Role Co-investigator Title Chiron Gene Therapy Long Term Safety Follow-up Site PI JLusher Sponsor Chiron Corp Trial StartEnd Date 0800 to 1210 Funding $1771
PUBLICATIONS Peer-Reviewed Publications
Reports of Original Work Notes Trainee or student mentored by MC Citation data from Web of Science
1 Iorio A Keepanasseril A Foster G Navarro-Ruan T McEneny-King A Edginton AN Thabane L WAPPS-Hemo co-investigator network Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Study Protocol JMIR Res Protoc 2016 Dec 155(4)e239
2 James PD Mahlangu J Bidlingmaier C Mingot-Castellano ME Chitlur M Fogarty PF Cuker A Mancuso ME Holme PA Grabell J Satkunam N Hopman WM Mathew P Global Emerging HEmostasis Experts Panel (GEHEP) Evaluation of the utility of the ISTH-BAT in haemophilia carriers a multinational studyHaemophilia 2016 Nov22(6)912-918
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
12
Clinical Trials Activities Role Co-Investigator Title Rescue Immune-tolerance Study in ITI Experienced Patients shyResist Experienced Source City of Hope Period of support 08152012-02122015 (Study is closed to accrual but following subjects enrolled) Direct Cost$ 5750
Role Co Investigator Title Single-dose pilot study of rivaroxaban in pediatric subjects with venous thromboembolism-12892 Source Bayer Corporation Site PI MRajpurkar Period of Support 061512-123115 Total Direct Cost $83961 (based on enrollment)
Role Co-investigator Title A Phase 3 Randomized Double Blind Placebo Controlled Study to Determine the Safety and Efficacy of Romiplostim in Thrombocytopenic Pediatric Subjects with Immune Thrombocytopenia (ITP) Principal Investigator M Callaghan Sponsor Amgen Inc Trial StartEnd Date 1211-0414 Funding $56000
Role Co Investigator Title - A Three Month Prospective Open Label Study of Therapy with FRAGMINreg (Dalteparin Sodium Injection) in Children with Malignancies and Venous Thromboembolism - FRAG-A001-201 Source Easai Inc Site PI MRajpurkar Period of Support 092810 - 052115 Total Direct Cost$5285742
Role Site Principal Investigator Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (25PYE) Sponsor Novo Nordisk Inc Trial startEnd Date 22309-122115 Funding Direct cost $44005 Indirect cost $11441
Completed Studies
Role Site Principal Investigator Title Evaluate the Activity a Site Specific of BDomain Deleted (BDD) Pegylated Recombinant FVIII Protein (BAY 94-9027) in Plasma Samples Measured with both Chromogenic and One Stage Assays Sponsor Bayer Trial StartEnc Date 8115- 8116 Funding $696400
13 Completed Studies
Role Co-investigator Title Safety and Efficacy of N8 in prevention and treatment of bleeds in pediatric Previously treated patients with Hemophilia A Site PI MRajpurkar Sponsor Novo Nordisk Trial StartEnd Date 1210 to 911 Funding $381729
Role Site PI Title 3760- Phase 3b Trial Investigating the Pharmacokinetics amp Safety Profile of Single IV Dose of rFXIII in Paediatric (1 to less than 6 Years Old) Subjects with Congenital FXIII A-Subunit Deficiency Sponsor Novo Nordisk Inc Trial StartEnd Date 1110-0112 Funding $ 4315752
Role Co-investigator Title Universal data and serum specimen collection (UDC) system for hemophilia Sponsor Centers for Disease Control (CDC) Site PI JLusher Trial StartEnd Date 0610 to 511 Funding $48000
Role Site PI for multi center trial Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (N13 3720) (Mentor 2) Sponsor Novo Nordisk Inc Trial StartEnd Date 0410- 1214 Funding $ 5544504
Role Principal Investigator Title Prospective ADVATE ITI Registry (Pair) Sponsor Baxter Trial StartEnd Date 210 -411 Funding $2000
Role Co-investigator Title Mechanisms of Race Based Differences in Factor VIII Immunogenicity in Hemophilia Sponsor NIH Supleveda Site PI JLusher Trial StartEnd Date 0909 to 0911 Funding $70000
Role Co-investigator Title Treatment of Congenital Factor VII deficiency A prospective observational studySTER [Seven Deficiency Treatment Registry] Site PI MRajpurkar Sponsor Quintiles Inc Trial StartEnd Date 709 to 1210 Funding $2800
14 Completed Studies
Role Site PI for multi center trial Title Prophylaxis Patient Case Collection (PRO-PACT) Sponsor Novo Nordisk Inc Trial StartEnd Date 409-0510 Funding $3984
Role Co-investigator Title Phase 1 Prospective Randomized Crossover Study to Compare the Pharmacokinetics and Safety of rAHF-PFM Reconstituted in 2mL versus 5mL SWFI in Previously Treated Severe Hemophilia A Patients Site PI JLusher Sponsor Baxter BioScience Trial StartEnd Date 208- 310 Funding $34272
Role Consultant Title Thromboelastographic evaluation of hypercoagulability after Fontanrsquos surgery Site PI MRajpurkar Sponsor CRCM Trial StartEnd Date 706 to 1210 Funding $ 32507
Role Site PI Title Recombinant anti-hemophilic factor manufactured and formulated without added human or animal proteins (rAHF PFM) evaluation of immunogenicity efficacy and safety in previously untreated patients with hemophilia A (PUP study) Sponsor Baxter Bioscience Trial StartEnd Date 404-0909 Funding $32582
Role Co-investigator Title Chiron Gene Therapy Long Term Safety Follow-up Site PI JLusher Sponsor Chiron Corp Trial StartEnd Date 0800 to 1210 Funding $1771
PUBLICATIONS Peer-Reviewed Publications
Reports of Original Work Notes Trainee or student mentored by MC Citation data from Web of Science
1 Iorio A Keepanasseril A Foster G Navarro-Ruan T McEneny-King A Edginton AN Thabane L WAPPS-Hemo co-investigator network Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Study Protocol JMIR Res Protoc 2016 Dec 155(4)e239
2 James PD Mahlangu J Bidlingmaier C Mingot-Castellano ME Chitlur M Fogarty PF Cuker A Mancuso ME Holme PA Grabell J Satkunam N Hopman WM Mathew P Global Emerging HEmostasis Experts Panel (GEHEP) Evaluation of the utility of the ISTH-BAT in haemophilia carriers a multinational studyHaemophilia 2016 Nov22(6)912-918
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
13 Completed Studies
Role Co-investigator Title Safety and Efficacy of N8 in prevention and treatment of bleeds in pediatric Previously treated patients with Hemophilia A Site PI MRajpurkar Sponsor Novo Nordisk Trial StartEnd Date 1210 to 911 Funding $381729
Role Site PI Title 3760- Phase 3b Trial Investigating the Pharmacokinetics amp Safety Profile of Single IV Dose of rFXIII in Paediatric (1 to less than 6 Years Old) Subjects with Congenital FXIII A-Subunit Deficiency Sponsor Novo Nordisk Inc Trial StartEnd Date 1110-0112 Funding $ 4315752
Role Co-investigator Title Universal data and serum specimen collection (UDC) system for hemophilia Sponsor Centers for Disease Control (CDC) Site PI JLusher Trial StartEnd Date 0610 to 511 Funding $48000
Role Site PI for multi center trial Title A Multi-Centre Open-Label Single-Arm and Multiple Dosing Trial on Safety of Monthly Replacement Therapy with Recombinant Factor XIII (rFXIII) in Subjects with Congenital Factor XIII Deficiency (N13 3720) (Mentor 2) Sponsor Novo Nordisk Inc Trial StartEnd Date 0410- 1214 Funding $ 5544504
Role Principal Investigator Title Prospective ADVATE ITI Registry (Pair) Sponsor Baxter Trial StartEnd Date 210 -411 Funding $2000
Role Co-investigator Title Mechanisms of Race Based Differences in Factor VIII Immunogenicity in Hemophilia Sponsor NIH Supleveda Site PI JLusher Trial StartEnd Date 0909 to 0911 Funding $70000
Role Co-investigator Title Treatment of Congenital Factor VII deficiency A prospective observational studySTER [Seven Deficiency Treatment Registry] Site PI MRajpurkar Sponsor Quintiles Inc Trial StartEnd Date 709 to 1210 Funding $2800
14 Completed Studies
Role Site PI for multi center trial Title Prophylaxis Patient Case Collection (PRO-PACT) Sponsor Novo Nordisk Inc Trial StartEnd Date 409-0510 Funding $3984
Role Co-investigator Title Phase 1 Prospective Randomized Crossover Study to Compare the Pharmacokinetics and Safety of rAHF-PFM Reconstituted in 2mL versus 5mL SWFI in Previously Treated Severe Hemophilia A Patients Site PI JLusher Sponsor Baxter BioScience Trial StartEnd Date 208- 310 Funding $34272
Role Consultant Title Thromboelastographic evaluation of hypercoagulability after Fontanrsquos surgery Site PI MRajpurkar Sponsor CRCM Trial StartEnd Date 706 to 1210 Funding $ 32507
Role Site PI Title Recombinant anti-hemophilic factor manufactured and formulated without added human or animal proteins (rAHF PFM) evaluation of immunogenicity efficacy and safety in previously untreated patients with hemophilia A (PUP study) Sponsor Baxter Bioscience Trial StartEnd Date 404-0909 Funding $32582
Role Co-investigator Title Chiron Gene Therapy Long Term Safety Follow-up Site PI JLusher Sponsor Chiron Corp Trial StartEnd Date 0800 to 1210 Funding $1771
PUBLICATIONS Peer-Reviewed Publications
Reports of Original Work Notes Trainee or student mentored by MC Citation data from Web of Science
1 Iorio A Keepanasseril A Foster G Navarro-Ruan T McEneny-King A Edginton AN Thabane L WAPPS-Hemo co-investigator network Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Study Protocol JMIR Res Protoc 2016 Dec 155(4)e239
2 James PD Mahlangu J Bidlingmaier C Mingot-Castellano ME Chitlur M Fogarty PF Cuker A Mancuso ME Holme PA Grabell J Satkunam N Hopman WM Mathew P Global Emerging HEmostasis Experts Panel (GEHEP) Evaluation of the utility of the ISTH-BAT in haemophilia carriers a multinational studyHaemophilia 2016 Nov22(6)912-918
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
14 Completed Studies
Role Site PI for multi center trial Title Prophylaxis Patient Case Collection (PRO-PACT) Sponsor Novo Nordisk Inc Trial StartEnd Date 409-0510 Funding $3984
Role Co-investigator Title Phase 1 Prospective Randomized Crossover Study to Compare the Pharmacokinetics and Safety of rAHF-PFM Reconstituted in 2mL versus 5mL SWFI in Previously Treated Severe Hemophilia A Patients Site PI JLusher Sponsor Baxter BioScience Trial StartEnd Date 208- 310 Funding $34272
Role Consultant Title Thromboelastographic evaluation of hypercoagulability after Fontanrsquos surgery Site PI MRajpurkar Sponsor CRCM Trial StartEnd Date 706 to 1210 Funding $ 32507
Role Site PI Title Recombinant anti-hemophilic factor manufactured and formulated without added human or animal proteins (rAHF PFM) evaluation of immunogenicity efficacy and safety in previously untreated patients with hemophilia A (PUP study) Sponsor Baxter Bioscience Trial StartEnd Date 404-0909 Funding $32582
Role Co-investigator Title Chiron Gene Therapy Long Term Safety Follow-up Site PI JLusher Sponsor Chiron Corp Trial StartEnd Date 0800 to 1210 Funding $1771
PUBLICATIONS Peer-Reviewed Publications
Reports of Original Work Notes Trainee or student mentored by MC Citation data from Web of Science
1 Iorio A Keepanasseril A Foster G Navarro-Ruan T McEneny-King A Edginton AN Thabane L WAPPS-Hemo co-investigator network Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Study Protocol JMIR Res Protoc 2016 Dec 155(4)e239
2 James PD Mahlangu J Bidlingmaier C Mingot-Castellano ME Chitlur M Fogarty PF Cuker A Mancuso ME Holme PA Grabell J Satkunam N Hopman WM Mathew P Global Emerging HEmostasis Experts Panel (GEHEP) Evaluation of the utility of the ISTH-BAT in haemophilia carriers a multinational studyHaemophilia 2016 Nov22(6)912-918
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
15 Peer-Reviewed Publications
Reports of Original Work
3 Rajpurkar M OBrien SH Haamid FW Cooper DL Gunawardena S Chitlur M Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders Illustrative Case Examples J Pediatr Adolesc Gynecol 2016 Feb 11
4 Quon D Chitlur M Rajpurkar M Simpson M OBrien S Flood V Hsieh L Acharya S Kruse-Jarres R Sood S Maahs J Profiles of Women Leaders in Hematology Am J Hematol 2016 Apr91 Suppl 1S6-S34
5 Zia A Callaghan MU Callaghan J Sawni A Bartlett H Backos A Marshall S Chitlur M Rajpurkar M Hypercoagulability in Adolescent Girls on Oral Contraceptives- Global Coagulation Profile and Estrogen Receptor Polymorphisms American Journal of Hematology 2015 May 25 [Epub ahead of print] Role study design data analysis manuscript writing Impact Factor 3477 Citations 0 PMID 26014094
6 Fogarty PF Mancuso ME Kasthuri R Bidlingmaier C Chitlur M Gomez K Holme PA James P Kruse-Jarres R Mahlangu J Mingot-Castellano ME Soni A the Global Emerging HEmophilia Panel (GEHEP) Presentation and management of acute coronary syndromes among adult persons with haemophilia results of an international retrospective 10-year survey Haemophilia 2015 Feb 17 [Epub ahead of print] Role study conception manuscript writing Impact Factor 2468 Citations 0 PMID25689278
7 Zia AN Chitlur M Rajpurkar M Ozgonenel B Lusher J Callaghan JH Callaghan MU Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype Haemophilia 2015 Jan21(1)124-32 Role study design data analysis manuscript writing Impact Factor 2468 Citations 0 PMID25545302
8 Kearney S Sharathkumar A Rodriguez V Chitlur M Valentino L Boggio L Gill J Neonatal circumcision in severe haemophilia a survey of paediatric haematologists at United States Hemophilia Treatment Centers Haemophilia 2015 Jan21(1)52-7Role data analysis manuscript writing Impact Factor 2468 Citations 0 PMID2547287
9 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature Hemophilia 2014 Jul20(4)464-71 Role study conception data analysis manuscript writing Impact Factor 2468 Citations 1 PMID24948404
10 Chitlur M Rivard GE Lillicrap D Mann K Shima M Young G The Factor VIII Factor IX Rare Coagulation Disorders Subcommittee of the Scientific Standardisation Committee of the International Society on Thrombosis Haemostasis Recommendations for performing thromboelastographythromboelastometry in hemophilia communication from the SSC of the ISTH J Thromb Haemost 2014 Jan12(1)103-6 Impact Factor 608 Citations 8 PMID24261669
11 Rajpurkar M McGrath E Joyce J Boldt-Macdonald K Chitlur M Lusher J Therapeutic and prophylactic ethanol lock therapy in patients with bleeding disorders Haemophilia 2014 Jan 20(1)52-7 Role data analysis manuscript writing Impact Factor 2468 Citations 2 PMID23906245
12 James P Kasthuri R Kruse-Jarres R Soni A Kulkarni R Bidlingmaier C Chitlur M Fogarty P Gomez K Holm PA Mahlangu J Mancuso ME Mingot-Castellano ME Dolan G Global Emerging HEmophilia Panel (GEHEP) A Multinational Collaboration for Advancing Hemophilia Research and Treatment Transfus Med Hemother 2013 Oct40(5)352-5 Role study conception design manuscript writing Impact Factor 2011 Citations 1 PMID242734
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
16 Peer-Reviewed Publications
Reports of Original Work
13 Pandey GS Yanover C Miller-Jenkins LM Garfield S Cole SA Curran JE Moses EK Rydz N Simhadri V Kimchi-Sarfaty C Lillicrap D Viel KR Przytycka TM Pierce GF Howard TE Sauna ZE PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A Nat Med 2013 Oct19(10)1318-24 Role Site PI in Multi center trial Manuscript review Impact Factor 28054 Citations 7 PMID24037092
14 Lewis KB Hughes RJ Epstein MS Josephson NC Kempton CL Kessler CM Key NS Howard TE Kruse-Jarres R Lusher JM Walsh CE Watts RG Ettinger RA Pratt KP PATH (Personalized Alternative Therapies for Haemophilia) Study Investigators Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance PLoS One 2013 May 88(5)e61120 Impact Factor3534 Citations 3 PMID23667433
15 Brennan SO Chitlur M Hypodysfibrinogenaemia and thrombosis in association with a newfibrinogen γ chain with two mutations (γ114TyrrarrHis and γ320Asp deleted) Thromb Haemost 2013 Mar 7109(6) Impact Factor 576 Citations 3 PMID20126833
16 Gomez K Chitlur M on behalf of the GEHEP Panel Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Thromb Haemost 2013 Jan 31109(4) Impact Factor 576 Citations 1 PMID23364754
17 Soucie JM De Staercke C Monahan PE Recht M Chitlur MB Gruppo R Hooper WC Kessler C Kulkarni R Manco-Johnson MJ Powell J Pyle M Riske B Sabio H Trimble S the US Hemophilia Treatment Center Network Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening Transfusion 2013 June53(5)1143-4 Role manuscript writing Impact Factor3568 Citations 2 PMID22998193
18 Ozgonenel B ZiaA CallaghanM ChitlurM RajpurkarM LusherJ Emergency department visits in children with hemophilia Pediatr Blood Cancer 2012 Nov 28 Role manuscript writing Impact Factor2562 Citations 1 PMID23192828
19 Kuhne T Berchtold W Michaels LA Wu R Donato H Espina B Tamary H Rodeghiero F Chitlur M Rischewski J Imbach P Newly diagnosed immune thrombocytopenia in children and adults a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group Haematologica 2011 Dec96(12)1831-7 Role data analysis manuscript writing Impact Factor5868 Citations 19 PMID21880634
20 Akash Nahar Cynthia Sabo Chitlur M YRavindranath JLusher Madhvi Rajpurkar Plasma Homocysteine levels Methyltetrahydrofolate Reductase Polymorphisms and the Risk of Thromboembolism in Children J Pediatr Hematol Oncol 2011 Jul33(5)330-3 PMID21602719
21 ChitlurM Sorensen B Rivard GE Young G Ingerslev J Othman M Nugent DKenet G Escobar M Lusher J Standardization of Thromboelastography A Report of the TEG-ROTEM Working Group Hemophilia Epub 2011 Feb 15 Impact Factor3534 Citations 43 PMID21323795 Listed as one of the top 5 most frequently cited articles from the journal Haemophilia in 2013shy
2014
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
17 Peer-Reviewed Publications Reports of Original Work 22 Callaghan M Rajpurkar M Chitlur M Warrier I Lusher JM Immune tolerance induction in 31
children with haemophilia A is ITI less successful in African-Americans Haemophilia Epub 2010 Dec 1 1-7 Impact Factor3534 Citations 10 PMID21118335
23 Nair SC Dargaud Y Chiltur M Srivastava A Tests of global haemastasis and their applications in bleeding disorders Haemophilia 2010 Jul 16 Suppl 5 85-92 Impact Factor3534 Citations 30 PMID20590862
24 Chitlur M Lusher JM Standardization of Thromboelastography- Values and Challenges Seminars in Hemostasis and Thrombosis 2010 Oct36(7)707-11 Epub 2010 Oct 26 Impact Factor3693 Citations 28 PMID20978991
25 Ahmed I Rajpurkar M Thomas R and Chitlur M Initial Lymphocyte Count and the Development of PersistentChronic Immune Thrombocytopenic Purpura Pediatric Blood and Cancer 2010 Sep 55(3) 508-11 Citations 7 PMID20658623
26 Tamary H Roganovic J Chitlur M Nugent DJ Consensus Paper-ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia Ann Hematol 2010 Apr 1 Vol89 Suppl 1 S5shy10 Impact Factor 2396 Citations2
27 BrennanS DavisR Chitlur M New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia Thrombosis and Hemostasis 103(2)478-79 2010 Impact Factor 576 Citations 3 PMID 20126833
28 Kupesiz A Chitlur M Hollon W Thomas R Tosun O Warrier I Lusher J Rajpurkar M Fibrinolytic Parameters in children with Non-Catheter Related Deep Vein Thrombosis- A Pilot Study Blood Coagulation and Fibrinolysis 2010 Jun21(4)313-9 (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 7 PMID20305541
29 KupesizA WarrierI RajpurkarM HollonW LusherJTosunO ChitlurM Tissue Plasminogen Activator Induced Fibrinolysis Standardization of Method using Thromboelastography Blood Coagulation and Fibrinolysis 2010 Jun21(4)320-4 [Epub 04152010] (Note DrKupesiz was a visiting researcher from Turkey) Role study conception design implementation data analysis manuscript writing Impact Factor 138 Citations 13 PMID20400895
30 Rajpurkar M Boldt-Macdonald K McLenon R Callaghan MU Chitlur M Lusher JM Becker C Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients Haemophilia 2009 Nov15(6)1267-712009 [Epub 06102009] Role data analysis manuscript writing Impact Factor 3468 Citations 13 PMID19659937
31 Chitlur M WarrierI RajpurkarM LusherJ Inhibitors in Factor IX Deficiency A Report of the ISTH-SSC International FIX Inhibitor Registry (1997-2006) Haemophilia 15(5) 1027-31 2009 Impact Factor 3468 Citations 43 PMID19515028
32 Chitlur M Warrier I Rajpurkar M Hollon W Llanto L Wiseman C Lusher JM Thromboelastography in children with coagulation factor deficiencies Brit J Haematol 142(2)250shy6 2008 Impact Factor 4959 Citations 25 PMID18492116
33 Rajpurkar MWarrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary Embolism in Children ndash A Single Centerrsquos Experience Thromb Res 119(6)699-703 2007 Role manuscript writing Impact Factor 576 Citations 20 PMID16879861
34 Lusher JM Chitlur M KogenateregFS antihemophilic factor rFVIII-FS Therapy 3(6)699-708 November) 2006
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
Pediatr Blood Cancer 2
18
Case Reports 35 Henry M Chitlur M Rajpurkar M Mastropietro CW Poulik J Ravindranath Y Myelofibrosis hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy J Pediatr Hematol Oncol 2014 May36(4)319-21 Role manuscript writing Impact Factor 0956 36 Chandrakasan S Ye CJ Chitlur M Mohamed AN Rabah R Konski A Heng HH Savaşan S Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma evidence for genomic instability 011 Jul 156(7)1143-5 Role manuscript writing 37 Siddiqui AH Chitlur MB Immune thrombocytopenic purpura in a 5 month old female with Rotavirus infection Pediatric Blood and Cancer 2010 Jan 654(4)633 38 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Pediatric Blood and Cancer Sep51(3)416-8 2008 Role manuscript writing 39 Rao S Moudgal M Chawla S Ahmed I Chitlur M Folk remedy as a cause of septicemia in a child with Leukemia Consultant for Pediatricians 6 (12) 2007 40 Chitlur M Abella E Singh TP Savasan S Severe neutropenia and thrombocytopenia following c ardiac transplantation in a child Pediatric Transplantation 9(1)94-96 2005 41 Bakshi S Chitlur M Cushing B Near-triploid acute Lymphoblastic leukemia with TELAML1 translocation Indian Pediatr 41(5)493-495 2004 Role manuscript writing 42 Chitlur M Bhambhani K Mohamed AN Ravindranath Y Savasan S Acute Megakaryoblastic Leukemia with a novel translocation t(1722)(q21q13) and synthetic liver dysfunction Cancer Genetics and Cytogenet 2004 Oct 15154(2)167-8 Review Articles 43 SHanmod RJesudas RKulkarni MChiltur Neonatal Haemostatic Disorders Issues and Challenges Semin Thromb Hemost 2016 Oct42(7)741-751 Review Impact Factor 3274 44 Chitlur M Young G Global assays in hemophilia Semin Hematol 2016 J an53(1)40-5 Review Impact Factor 3274 45 Zia AN Chitlur M Management of thrombotic complications in acute lymphoblastic leukemia In
dian J Pediatr 2013 Oct80(10)853-62 (Note DrZia was a fellow) Impact Factor 0919
46 Chitlur M Challenges in lab analysis of bleeding disorders Thromb Res 2012 Apr 5 Impact Factor2447 Citations 16
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
19 EditorialsCommentaries
47 Chitlur M Pipe SW Reding MT Kessler CM Overcoming the diagnostic and monitoring challenges for very rare bleeding disorders in the US the potential benefits of a centralized laboratory Haemophilia 2016 Jan22(1)15-9 Impact Factor 3468
48 ChitlurM PipeS RedingMT KesslerC Overcoming the Diagnostic and Monitoring Challenges for Very Rare Bleeding Disorders in the US The Potential Benefits of a Centralized Laboratory Accepted and in press Haemophilia Impact Factor 3468
49 Chitlur M Massicotte MP The Perfect Measure of Hemostasis- A Quest for the Holy Grail Thromb Res 2010 Jun125(6)481-2 Impact Factor 2447 PMID 1989617
Book Chapters
50 AU Zaidi MU Callaghan TSarkar MChitlur Neonatal Thrombosis and Coagulopathies Non- Malignant Hematology Abutalib et al eds Springer International Publishing Switzerland 2016
51 MChitlur SSarnaik Hemoglobinopathies and Sickle cell disease American Academy of Pediatrics Textbook of Pediatric Care McINerney TK Adam HM Campbell DE Kamat DM Kelleher KJ eds Elk Grove Village IL American Academy of Pediatrics 2014
52 Lusher JM Chitlur M Factor IX inhibitors in Hemophilia B IN Textbook of Haemophilia Second Edition Blackwell Publ (2010)
53 MChitlur RKulkarni Hemophilia and Related Bleeding Disorders Conns Current Therapy 2010-2016 424-430 Bope ET Rakel RE Kellerman R eds Saunders Publications Philadelphia PA
54 Kulkarni R Chitlur M Lusher J Chapter 6 Treatment of Congenital Coagulopathies Transfusion Therapy Clinical Principles and Practice 3rd Edition Editor Paul D Mintz MDAABB Press Bethesda MD 2011 Pg 167-208
55 Ayesha Zia Chitlur M Disorders of Fibrinogen Handbook of Hematology Research Hemorheology Hemophilia and Blood Coagulation Nova Science Publishers Inc Hauppauge NY USA 2011
56 ChitlurM LusherJ Factor VIII and IX inhibitors in Hemophilia Hemostasis and Thrombosis-Practical guidelines in Clinical Management Editors Hussain Saba and Harold Roberts MD Blackwell Publishing Ltd 2014 Pg 82-92
57 ChitlurM LusherJ Treatment of hemophilia plasma-derived clotting factors eBook on Hemophilia Editor Eric Berntorp MD Future Science Group London UK 2014 Pg 35-44
58 Chitlur M Lusher J Factor VIII and IX Inhibitors in Hemophilia Hemostasis and Thrombosis Practical Guidelines in Clinical Management Editors Hussain ISaba Harold RRoberts MD Wiley Blackwell Ltd 2014 Pg 82-92
59 ChitlurM SimpsonM Role of Global Assays in Thrombophilia Testing and Thrombosis Monitoring Pediatric Thrombotic Disorders Cambridge University Press 2015 Pg 142-1
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
20 Published Abstracts 1 DCooper CKessler EPeerschke MChitlur RKulkarni GEberhart RGut Overcoming
barriers to diagnosis of bleeding disorders including Acquired Hemophilia by health practitioners The coags uncomplicated iphoneAndroidWeb application J Thromb Haemost Vol 11 Special Issue SI Suppl 2 Pg 810-811 July 2013
2 Ayesha N Zia Michael Callaghan Meera Chitlur Jeanne Lusher Madhvi Rajpurkar ldquoToward Prediction of Thrombosis in Adolescent Girls on Estrogen Containing Contraceptives Global Coagulation Profiles and Estrogen Gene Polymorphismsrdquo Blood Vol120 Issue 21 Abstract 2254 Nov 16 2012
3 M Chitlur LRao MCallaghan MRajpurkar JLusher Thromboelastography for monitoring of hemostatic changes following factor administration Blood Vol 120 Issue 21 Abstract 3373 Nov 16 2012 (Note DrRao was a fellow)
4 Ayesha N Zia Madhvi Rajpurkar Michael Callaghan Jeanne Lusher Meera Chitlur ldquoThe Utility of Thromboelastography as a Screening test for Bleeding Disordersrdquo Ped Blood and Cancer Vol 58 Issue 7 Special Issue SI Pg 1035 July 2012
5 MRajpurkar CSabo AZia MChitlur et al Pulmonary Embolism at a Tertiary Care Childrens Hospital Am J Haemat Vol 87 Suppl 1 Pg 188-189 May 2012
6 M Chitlur S Kandagatla M Rajpurkar HWalters RDelius JLusher HematologicComplications associated with Ventricular Assist Devices (VADrsquos) in 13 children from a single center Blood Vol 118 Issue 21 Pg 983 Nov 18 2011
7 Ayesha Zia Madhvi Rajpurkar Michael Callaghan Cynthia Sabo Mary Jane Frey Jeanne Lusher Meera Chitlur Epistaxis In Glanzmannrsquos Thrombasthenia ndash Salt Pork Revisited Haemophilia Vol 17 Issue 3 Pg 569 May2011
8 MRajpurkar MChitlur MRecht DCooper Use of Recombinant Activated FVII in Glanzmann Thrombasthenia A Review of the Literature J Thromb Haemost Vol 9 Suppl 2 Pg 340 Abstract P-TU-102 Jul 2011
9 Rajpurkar M Sabo C Zia A Callaghan M Ozgonenel B Chitlur M Lusher J Racial Differences In Pediatric Venous Thromboembolism Blood Vol 116 Issue 21 Pg 1305 Nov 19 2010
10 Naji Z Rajpurkar M Chitlur M Chu R Savasan S Callaghan MU Mycophenolate Mofetil Therapy is a Steroid Sparing in Childhood and Young Adult Chronic ITP and Evans Syndrome Blood Vol 116 Issue 21 Pg 1305-1306 Nov 19 2010
11 MCallaghan ZNaji JMiller AFribley MChitlur JLusher and MRajpurkar ldquoMycophenolate Mofetil Reduces T-Cell Activation Gene Expression and is Steroid Sparing in Chronic ITP and Evansrsquo SyndromerdquoBlood Vol116 Issue 21 Pg 1305-1306 Nov 19 2010
12 Rajpurkar M Zia A Sabo C Thomas R Chitlur M Frey M Lusher J Recurrent Thromboembolism in a tertiary care center Blood Vol 114 Issue 22 Pg 1165-1166 Nov 20 2009
13 JainS Chitlur M Thrombin Generation in Children with Hemophilia Pediatr Blood Cancer Vol 52 Issue 6 Pg 712 Jun 2009 [Note Dr S Jain was a Year III Pediatric Resident]
14 Rajpurkar M Chitlur M Turner D Forbes T Sullivan N Zilberman M Lusher J Evaluation of hypercoagulable state following staged repair (Fontan surgery) for univentricular heart disease Haemophilia Vol 15 Issue 2 Pg 628-629 Mar 2009
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
21 Published Abstracts 15 Chitlur M Rajpurkar M Walters H III Delius R DeBano C Larson K McGivern C Lusher J
Monitoring of anticoagulation in Children on Ventricular Assist Devices (VAD) Trials and Triumphs Haemophilia Vol 15 Issue 2 Pg 629 Mar2009
16 Chitlur M Ware E Kannan S Hollon W Buck S Rajyalakshmi I Kannan R Warrier I Rajpurkar M Lusher J Influence of nanopolymers with different end-functionalities on platelet function and the coagulation cascade Blood 108(2) pg 87b abstract 4038 2006
17 Chitlur MB Hollon W Lusher JM Rajpurkar M Llanto L Wiseman C Warrier I Diagnostic Utility Of The PFA-100 in Children with von Willebrand Disease and Platelet Function Defects (Abstract 753539) Pediatr Blood Cancer
18 Chitlur MB Warrier I Rajpurkar M Hollon W Llanto L Lusher JM Thromboelastography in children with coagulation factor deficiencies Presented at the 47th Annual Meeting of the American Society of Hematology (ASH) December 10-13 2005 Atlanta GA Blood 106 (11 part 1 of 2) p 605a abstract 2139 2005
19 Rajpurkar M Warrier I Chitlur M Sabo C Frey MJ Hollon W Lusher JM Pulmonary embolism in children Presented at American Society of Hematology Forty-sixth annual meeting (ASH) Dec 4shy72004 Blood 104 (11 part 1 of 2)abstract 2606 2004
20 Chitlur M Hollon W Buck S Llanto L Thomas R Sarnaik S Warrier I Platelet activity in sickle cell vaso-occlusive episodes Blood 102(11 part 2 of 2) p 69b abstract 3982 2003
21 Chitlur M Devarahally SSR Severson RK Lucas DR Ravindranath Y Hamre MR Concurrent cancers in childhood and adolescence Ped Research Vol 53 Issue4 Suppl S Pg 300A Abstract 1712 May 2003
22 Callaghan M Chitlur M and Lusher JM Follow-up of chronic ITP in 22 children Blood 100 (11 pt 2 of 2)84b abstract 3811 2002
PRESENTATIONS
Podium Presentations (refereed) 23 TSarker MU Callaghan WHollon MChitlur Thromboelastography(TEG) and Thrombin
Generation Assay (TGA) in Severe Haemophilia Following Factor Replacement Therapy Oral Presentation at the 13th Annual Pediatric Research Day Michigan State University April 2014
24 Chitlur M Giblin K Rajpurkar M Lusher JM Warrier I Pediatric thromboembolism ndash a look at the risk factors associated with DVT and arterial ischemic strokes in children A single institutions experience Oral Presentation at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago IL
Poster Presentations (refereed) 25 Katherine Regling Srikruthi Kakulavarapu Ronald Thomas Wendy Hollon and M Chitlur
MD Utility of Thromboelastography for the diagnosis of Von Willebrand Disease Presenated at the American Society of Hematology Annual Meeting Dec 5 2016 San Diego CA
26 M Chitlur MD M Rajpurkar MD MJ Frey RN BSN CPN M Recht MD PhD S Peltier MPH PA-C M Tarantino MD D Stephens RN MS CPNP EJ Neufeld MD PhD C Guelcher MS PPCNP-BC C Kessler MD DL Cooper MD MBA Unmet Needs in Diagnosis and Management of Glanzmannrsquos Thrombasthenia (GT) Perceptions of US Health Care Professionals (HCPs) Patients and Parents Presented at the 9th Annual Congress of the European Association for Haemophilia and Allied Disorders Malmouml Sweden Feb 3-5 2016
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
22 Poster Presentations (refereed)
27 P Navalkele Bulent Ozgonenel WHollon M Chitlur A rare case of Factor XIII deficiency along with Von Willebrand Disease-Thromboelastographic findings Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
28 M Chitlur MRajpurkar M Recht DL Cooper R dOiron R Zotz M Poon G di Minno Independent Adjudicator Assessment of Efficacy of Recombinant Factor VIIa in BleedingSurgery in the Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 15-16 2015
29 M Recht Madhvi Rajpurkar M Chitlur DL Cooper Roseline dOiron R Zotz Giovanni di Minno M Poon The Adjudication Process and Results of Assessment of Refractoriness of the Observational Multinational Glanzmannrsquos Thrombasthenia Registry (GTR) Presented at 2015 Scientific Symposium of the Haemophilia Thrombosis Research Society April 2015
30 MChitlur MRecht MRajpurkar ENeufeld CKessler MReding MTarantino DCooper ldquoUnmet Needs in Diagnosis and Treatment of GT Perceptions of US Hematologists and Nursesrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
31 MRecht MRajpurkar MChitlur MReding MFrey SPeltier CGuelcherDStephens DCooper ldquoImpact of Glanzmann Thrombasthenia Perceptions from US Patients and Parentsrdquo Presented at the 56th Annual American Society of Hematology meeting San Francisco CA Dec 7shy10 2014
32 Zia MCallaghan JLusher MChitlur MRajpurkar Venous Thrombosis in adolescent girls on oral contraceptives- association with estrogen gene polymorphisms Presented at the 59th annual International Society of Thrombosis and Hemostasis meeting July 1 2013
33 J M Soucie C Staercke M Chitlur R Gruppo WC Hooper C Kessler R Kulkarni M Manco-Johnson P Monahan M Oakley J Powell M Pyle M Recht B Riske H Sabio S Trimble amp the US Hemophilia Treatment Center Network Evidence for Continued Transmissionof Parvovirus B19 in Plasma-derived Factor Concentrates after Implementation of B19 Nucleic Acid Plasma Mini-pool Screening Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
34 Buumllent Oumlzgoumlnenel Ayesha Zia Michael Callaghan Meera Chitlur Madhvi Rajpurkar JeanneLusher Emergency Room Visits In Children with Hemophilia Presented at the 53rd Annual American Society of Hematology meeting San Diego California Dec 10-13 2011
35 Chitlur M Ewing N Kraut EH Cooper DL Use of Recombinant Factor VIIa (rFVIIa) for Bleeding and Surgery in Glanzmannrsquos Thrombasthenia (GT) and Other Platelet Disorders (OPDs) An Analysis from the Hemophilia and Thrombosis Research Society (HTRS) Registry Poster presentation at the Annual Hemophilia amp Thrombosis Research Society Scientific Symposium April 28-30 2011 and the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
36 Chitlur M and KGomez on behalf of GEHEP International Survey of laboratory tests used in the diagnosis and evaluation of Hemophilia A Presented at the Annual Hemophilia amp Thrombosis Research SocietyNASCOLA Scientific Symposium April15-17 2010 Chicago IL
37 Nahar A Ravindranath Y Chitlur M Frey M Sabo C Lusher J Rajpurkar M Plasma homocysteine levels Methelene TetraHydroFolate Reductase (MTHFR) polymorphism and the risk of thromboembolism in children ndashHaemophilia April1 2009
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
23 Poster Presentations (refereed)
38 Kupesiz OA Chitlur M Rajpurkar M Lusher J Hollon W Warrier I Tissue Plasminogen Activator Induced Fibrinolysis - Standardization of Method on TEG Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva SwitzerlandJuly 6ndash12 2007
39 Kupesiz OA Rajpurkar MA Chitlur MB Lusher JM Hollon W Warrier I Fibrinolytic Parameters In Children With Non-Catheter Related Deep Venous Thrombosis Presented as poster at the XXIst Congress of the International Society on Thrombosis and Haemostasis Geneva July 6-12 2007
40 Ahmed I Rajpurkar M Chitlur M ldquoIs the Initial Lymphocytic Count a Significant Risk Factor for the Development of Chronic Immune Thrombocytopenic Purpura A Single Institutional Reportrdquo Poster Presentation presented at the ASPHO annual meeting at Cincinnati OH in May 2008
41 Rajpurkar M Chitlur M Warrier I Sabo C Hollon W Lusher JM Impact of establishment of a thrombosis service at a Childrens Hospital -A single center experience Poster presentation at XXVII International Congress of the World Federation of Hemophilia Vancouver Canada 52106shy52506
42 Wang ZJ Chitlur M Inoue S Onwuzurike N Rajpurkar M Lusher J and Warrier I Decreased clearance of VWF large multimers in a patient with Type IIb VWD following ITP Presented at the Hemophilia amp Thrombosis Research Society (HTRS) meeting Chicago IL April 20-21 2006
43 Chitlur M Lusher JM Rajpurkar M Hollon W Llanto L Wiseman C Warrier I Thromboelastography in children with severe coagulation factor deficiencies Presented at the Hemophilia and Thrombosis Research Society (HTRS) annual symposium April 7 2005 Chicago
Invited LecturesPresentations Internationalnational
1 Monitoring Anticoagulation Is there a need for alternative methods Presented at 62nd Annual International Society of Thrombosis and Hemostasis Scientific Standardization Committee Meeting May 29 2016
2 Coagulation Laboratory Testing Made Easy- CME Course 56th Annual American Society of Hematology meeting San Francisco CA Dec 7-10 2014
3 Neonatal Intracranial hemorrhage Presented at the 60th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Milwaukee WI June 25 2014
4 Addressing the Treatment Needs of Carriers with Hemophilia A and B Presented at the National Hemophilia Foundations 65th Annual Meeting Anaheim CA Oct 3-5 2013
5 Are laboratory tests for global hemostasis ready for prime time and how will these assays be used for optimizing replacement therapy with the new extended half-life products Presented at the National Hemophilia Foundation- Medical and Scientific Advisory Council (MASAC) Meeting Orlando FL November 10 2012
6 Standardization of whole blood viscoelastic measurement of clot formation and clot stabilityshyPresented at the 58th International Society on Thrombosis and Haemostasis-Scientific and Standardization Committee Meeting Liverpool UK June 29 2012
7 Report of TEGROTEM working party ndash Future strategies Invited Speaker at the XXIIIrd Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting July 23-28 2011
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
24 Invited LecturesPresentations
Internationalnational
8 Current Strategies for the Surgical Management of Patients with Congenital Bleeding Disorders Hemostasis Testing The Clinical Utility of Current and Emerging Assays Invited speaker at the American Society of Pediatric HematologyOncology April 14 2011
9 Clinical Utility of Thromboelastography in Bleeding Disorders ndash Invited speaker at the World Federation of Hemophilia (WFH) biennial Congress July 10-14 2010 in Buenos Aires Argentina
10 Standardization of Thromboelastography International Society of Thrombosis amp Hemostasisrsquo Scientific amp Standardization Committee (SCC) May 2010 Cairo Egypt
11 Clinical Applications of Global Hemostatic Assays- Invited speaker at the HTRS amp NASCOLA Annual Scientific Symposium Chicago IL April 15-17 2010
Invited LecturesPresentations Localregional
1 Novel Therapies in Hemophilia A Presented at Rush University Medical Center Nov 2016
2 ldquoThromboelastography Interpretation and how to use the data Presented at the Detroit Trauma Symposium Nov 6 2015 and Nov 9 2016
3 Challenges with women and Girls with bleeding Presented at the Great Lakes Regional Meeting Oct 10 2016
4 Treatment of VWD Presented at the Midwest Regional VWD Conference Nov 3 2015
5 Effective Networking for the LAN Group- Ideas and Incentives Presented at the Women and Girls with Bleeding Disorders Learning Action Network- Education and Clinic of Excellence Workshop May 19 2015
6 Laboratory Monitoring of Long Acting Factor Concentrates Presented at the Hemophilia Regional Meeting Oct 9 2014
7 ldquoI am a carrier of hemophiliardquo What this means to the carrier of the bleeding disorder Presented at the Hemophilia Regional Meeting Oct15 2012
8 Monitoring Anticoagulation IN ECMO-Do Global Hemostasis Assays play a role Invited speaker at the ldquoThe 27th CNMC Symposium ECMO and Advanced Therapies for Respiratory Failurerdquo Keystone Colorado February 24 2011
9 Joint Disease in Patients with Hemophilia ndash Evaluation and Management Invited speaker at the Great Lakes Inhibitor Support Network (GLISN) meeting Frankenmuth MI March 5-6 2010
Invited Seminars and Grand Rounds
1 ECMO- Management of Anticoagulation Invited seminar at the Joint CV SurgeryPICU conference Dec 7 2016
2 Whats new in Coagulation Global Assays- To do or Not to Do Invited grand rounds speaker at Michigan State University Dec 9 2016
3 Thromboelastography- guide to use in anesthesiology Invited seminar at the CME conference for the Department of Anesthesiology at Childrens Hospital of Michigan Aug 6 2014
4 Global Hemostasis Assays- Trials and Triumphs in standardization and utilization Invited speaker at Nationwide Childrenrsquos Hospital Columbus Ohio Dec14 2012
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010
25
Invited Seminars and Grand Rounds
5 Assessment of Haemostasis in children on mechanical circulatory support and extracorporeal membrane oxygenation- Do Global haemostatic assays have a role Invited speaker at Cincinnati Childrenrsquos Hospital and Medical center Oct 30 2012
6 Global Assays in Hemostasis- New Innovations at Childrenrsquos Hospital of Michigan Grand Rounds at Childrenrsquos Hospital of Michigan Detroit MI Nov 18 2011
7 Global Assays in Hemostasis Invited speaker for Grand Rounds at Devaraj Urs Medical College Kolar Karnataka India August 16 2010