Volume is Vital. End the Debate With Daxor.
The New Measure of Care
DAXOR BVA-100 BLOOD TEST®
Direct Measurement of Total Blood, Plasma, Red Cell VolumeAdministered at Point of Care, Samples Lab Processed
98%ACCURATE
TEST RESULTS 1 HOUROR LESS
Achieve Better Outcomes
Providing a Solution for the Most Common and Costly ConditionsBlood volume derangements are common in a broad range of medical and surgical conditions including heart failure, critical care, sepsis, syncope, surgical blood loss, and ARDS.
DAXOR BVA-100 BLOOD TEST Leader in the New Measure of CareOver 50,000+ tests performed to evaluate blood volume and used daily in major centers across the U.S. Dozens of peer-reviewed studies have established the value of Blood Volume Analysis (BVA), confirming that accurate blood volume measurement leads to better outcomes.
Heart Failure SyncopeSepsis ARDSCritical Care Surgical Blood Loss82%30-Day
Mortality Rate
56%30-Day
Readmission Rate1-Year Mortality Rate
Significantly Reduce Heart Failure Mortality & Readmissions*
Propensity matched-control trial in community hospital | n = 245, Mixed HFpEF/HFrEF
86%
2.32 QALYAverage Life-Extension
Per Pa�ent
Than far below the threshold of $50,000
5X MoreCost-Effec�ve
Private Insurance Inpa�ent Outpa�ent
Medicare Codes:CPT & APC
(P<0.001) (P<0.001) (P<0.001)
66%Mortality
20%LOS
Blood Volume Measurements Improved ICU Survival†Prospec�ve randomized control trial in surgical ICU | n = 100, 70% Sep�c Shock/Sepsis/40% ARDS
44% Change inTreatment Strategy
Versus Standard Care
36 Hour EarlierTreatment Decision
(P=0.03) (P=0.14)
Blood Volume-Guided Treatment Extremely Cost-Effec�ve‡
Retrospec�ve analysis in hospitalized heart failure pa�ents | n = 245, Mixed HFpEF/HFrEF
Well above 0.227 previously reported§
Excellent Value in Healthcare
Approved for Reimbursement
Where Daxor BVA-100 Blood Test Makes an Impact
InpatientIndividualize treatment strategy & targets
Post-SurgeryEvaluate progress & illuminate red cell status
Dialysis CenterObservation Unit
Heart Failure Clinic
Emergency DepartmentAutonomic Clinic
OutpatientOptimize care to prevent readmission & deterioration
AdmissionInform fluids & red cell management early
DischargeConfirm readiness &
adjust medications
Inform strategy & avoid unnecessary admissions
Optimize care to prevent readmission & deterioration
*Strobeck JE, Feldschuh J, Miller WL. Heart failure outcomes with volume-guided management. JACC-HF, vol. 6, no. 11, (2018), pp. 940-947. † M. Yu, K. Pei, S. Moran, et al. A prospective randomized trial using blood volume analysis in addition to pulmonary artery catheter compared with pulmonary artery catheter alone to guide shock resuscitation in critically ill surgical patients. Shock, 35 (2011), pp. 220-228. ‡ Strobeck JE, Feldschuh J, Williams BA, et al. Cost-Effectiveness Analysis of Early Blood Volume-Guided Management in Hospitalized Heart Failure. Presented at HFSA 2020 Virtual Conference. §J Rankin, et al. Valuing health-related quality of life in heart failure: a systematic review of methods to derive quality-adjusted life years (QALYs) in trial-based cost–utility analyses. Heart Failure Reviews (2019), 24:549–563.
Indirect Measures Offer Low Clinical Utility as Indicators of True Intravascular Volume StatusClinical signs and symptoms typically describe fluid predominantly in the interstitial compartment. Hemodynamics, biomarkers and other common indirect measures can be costly, invasive, and are neither sensitive nor specific indicators of actual intravascular volume status.
The Smallest Volume is the Most Vital for SurvivalIt is crucial to differentiate between interstitial overload and intravascular overload. The BVA-100 blood test directly quantifies the intravascular blood, plasma, and red cell volume giving you actionable information you need to achieve optimal fluid management.
Interstitial: 11-13 L | Intracellular: 27-30 L | Intravascular: 3.0-3.5 L
3 Fluid Compartments
Intracellular Fluid
Interstitial Fluid
Patient with the Same Hct May Be Highly Discordant in True Red Blood Cell Volume Status
Heterogeneity in Total Blood Volume and Red Blood Cell Volume Status is Common – One Size Treatment Does Not Fit All
**Miller, WL. Volume and Pressure in Heart Failure: Complementary, But Not Two Sides of the Same Coin. Presented at HFSA 2018 Conference.
Frequency Distribution of Quantitated VolumeDeficit/Excess at Admission (n = 50)
Managing Volume Derangement is a Challenge with High Stakes
The Goal: Get Patients to Their Optimal Blood VolumeIntravascular Fluid
∏Miller WL. Fluid Volume Overload and Congestion in Heart Failure: Time to Reconsider Pathophysiology and How Volume Is Assessed. Circ Heart Fail. (2016), 9:e002922.
∏
NormovolemicNormal pressure
Vasoconstriction Hypertension
Increased pressure Normovolemic
Volume Expanded Hypertension
Increased pressure Hypervolemic
Pressure is Not Volume – Volume is Not Pressure Neither CVP, PCWP, nor dPAP accurately reflect intravascular volume status. Quantitative blood volume measurement (BVA) and cardiac hemodynamics provide complementary but different information.**
Is the increase in pressure due to vasconstriction or volume expansion?
Unlock Answers With BVAThe BVA-100 Test Report provides a comprehensive and precise overview of blood volume status unique for each patient.
TESTRESULTS1 HOUROR LESS
Blood samples readyfor processingBlood draws 6 minutes apart
Pre-test blood draw to establish background radia�on level
Tracer injec�on
0 min
Tracer diffusion
Centrifuge
BVA-100
BVA-100 Test Report
Plasma
Red blood cells
amBlood samples readymples rea
98% Accurate Measurement of Intravascular Blood Volume Utilizing the ‘Gold Standard’ MethodologyThe BVA-100 Blood Volume Analyzer quantifies blood volume using the indicator tracer dilution technique. The test is administered at the bedside, blood samples are drawn and sent to the laboratory for processing.
BVA Result Deviation from Ideal Excess/Deficit %
Degree of volume derangement relative to calculated patient-specific ideals to guide individualized treatment.
Albumin Transudation Slope provides the rate at which the albumin transudates out of circulation through the capillary bed. A rate of approximately 0.25% per minute is considered normal. In a patient with increased capillary permeability, this rate may increase.
Reference RangePatient Result
High: 0.4 to 0.5
Very High: >0.5
Albumin Transudation Analysis/Slope (%/min)
Patient Result Normal Female
Normalized Hct is the target Hct if total blood volume were adjusted to normal by changing the plasma volume. A useful individualized target for treatment.
Hematocrit Analysis
Total Blood Volume (+24.2) indicates volume overload
Peripheral Hct (30.7%)
Albumin Transudation normal
Red Blood Cell Volume (-4.8%) indicates normal
Total Blood Volume 6295 mL +1226 mL +24.2% Severe Excess
Red Blood Cell Volume 1740 mL -87 mL -4.8% Normal Deficit
Plasma Volume 4555 mL +1313 mL +40.5% Extreme Excess
0.09 Normal: 0 to 0.25Elevated: 0.25 to 0.4
Peripheral Venous Hct 30.7% 37-41%
Normalized Hct (nHct) 38.1% 37-41%
Normalized Hct (38.1%) suggests dilutional anemia
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Daxor Corporation 107 Meco Lane, Oak Ridge, TN 37830Phone: 865-425-0555 | Fax: 865-425-0551
[email protected] | daxor.com
Daxor Corporation is the global leader in blood volume measurement technology focused on blood volume testing innovation. We developed and market the BVA-100 (Blood Volume Analyzer), the first diagnostic blood test cleared by the FDA to provide safe, accurate, objective quantification of blood volume status and composition compared to patient-specific norms for use in a broad range of medical and surgical conditions.
Partner With the Dedicated Leader in BVAAs the pioneer in blood volume analysis, Daxor provides education and the resources needed to ensure easy onboarding along with continuing support to drive maximum value from your BVA system throughout your facility. With a long-standing commitment to improving care and numerous studies validating our technology, Daxor is completely focused on advancing healthcare by enabling optimal fluid management with blood volume analysis. Our vision is optimal blood volume for all.
Volume is Vital. End the Debate With Daxor.
Discover more at daxor.com or call us at 865-425-0555.
