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Dr. Priti Vaidyanathan Sabinsa Europe GmbH
16 April 2015 In-Cosmetics 2015
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What is D’Cosmix™?
D’Cosmix™ is the outcome of over 2 decades of unrivalled competence of the Sabinsa research team to pioneer and innovate, novel dermaceuticals from natural sources.
D’Cosmix™ is an intelligent fusion of science and performance. D’Cosmix™ caters to the broad palette of applications in the Cosmeceutical and Personal care range.
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Why D’Cosmix™ ? Provides innovative solutions to create unique formulations. Helps unravel multiple facets with the “powerhouse” of
synergistic naturals. Brings balance to your search of novelty in formulations. Offers solutions to the boundless challenges that your
formulations face. Helps your products stand out in the fiercely competitive
market. Positively influences the ease of formulations. Uplifts the spirit of formulations…Naturally !
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Skin firming Skin regeneration
Skin hydration Skin protection
Skin calming Skin nourishing Skin energizing
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D’Cosmix™ – Application Focus.
Skin lightening Skin brightening Skin conditioning
Skin de-stress Hair growth
Hair fall control Hair conditioning
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D’Cosmix™ Range
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D’Cosmix Range Blend Broad range of application
1 AgeLess Complex DCx Skin firming, Skin regeneration
2 AcNil DCx Anti-acne, Skin protection, Skin calming
3 CosmeVit DCx Skin conditioning, Skin energizing, Skin lightening and Skin de-stress
4 DermaSoothe DCx Skin conditioning, Skin calming
5 DerMoist DCx Skin hydration, Skin nourishing
6 D’Heal DCx Skin protection, Skin calming
7 KeraCon DCx Hair growth, Hair fall control
8 MelaLite DCx Skin lightening, Skin brightening
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AgeLess Complex DCx
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1. AgeLess Complex DCx
AgeLess Complex DCx effective ingredients that offer pro-active protection against time and environmental aggression and synergistically help to repair, rejuvenate and condition the skin naturally!!
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Ageless Complex DCx Ingredient Rationale
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Barley Beta Glucans - Recognized for their role in maintaining collagen balance, it helps protect the integrity of the skin matrix
Niacinamide - Clinically validated to balance skin moisture and manage hyperpigmentation. It inhibits melanosome transfer to keratinocytes
N-Acetyl Glucosamine – Maintains the natural reserve of skin moisture
pTeroWhite® - Known for its melanogensis inhibition potential
Tocopheryl Acetate- Cell membrane protectant and potent antioxidant
Cosmoperine® - Patented and proven dermal penetration enhancer
Cosmoperine® U.S Patent No. 6,849,645. Japanese Patent No. JP4098985. Great Britain Patent No. GB2380675
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Ageless Complex DCx In vitro study
Activity Result
Anti-collagenase activity 13.56% inhibition at 1000 µg/ml
Anti-elastase activity 11.5% inhibition at 1000 µg/ml
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Efficient control of wrinkles Increase collagen formation Enhance elasticity of the skin Promote evenness of skin tone
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AgeLess Complex DCx - Deliverables
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Range Dosage Form Dose Anti aging Cream 1-3 %
Translucent Serum 1-3% Anti Wrinkle Cream 0.5-2% After Suncare Cream, Lotion 1-2%
AgeLess Complex DCx - Suggested Usage and Dosage
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AcNil DCx
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2. AcNil DCx
AcNil DCx provides an effective nutrient composite offering a multi-pronged approach to acne management by addressing different skin concerns such as P acne activity, inflammation, irritation and increase sebum secretion.
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Some of the common causes of acne • Growth and multiplication of acne causing
bacterium Propionibacterium acnes. • Higher levels of the hormone
Dihydrotestosterone by the activity of the enzyme 5-alpha reductase.
• Increase in androgens during puberty and adolescence which in turn, triggers an enlargement of the sebaceous glands.
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Causes of acne
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AcNil DCx Ingredient Rationale
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Monolaurin - A produce from Cocus nucifera with proven antiacne benefits
Olive oil – Contains natural squalene and affords skin soothing benefits
Aloe vera – Clinically validated to promote wound healing and soothing
Niacinamide - Clinically validated to manage depigmentation and acne breakouts. It inhibits melanosome transfer to keratinocytes
Zinc Monomethionine – Improves skin immunity
Policosanol – Clinically evaluated to reduce sebum production
Coleus Oil – Potent antimicrobial
Ginger SCFE 20%- Anti-inflammtory, Antimicrobial
Mandelic acid- Mild exfoliate and anti acne
Policosanol U.S Patent No. 7,217,546. Indian Patent No. IN229695.
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AcNil DCx In vitro Antimicrobial activity
Inhibitory activity against P acnes bacteria – Minimal Inhibitory Concentration – 500 µg/ml
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Reduce sebum production Inhibit P. acnes proliferation Minimize recurrence of acne break outs Reduce inflammation Diminish acne scars
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AcNil DCx - Deliverables
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Range Dosage Form Dose Anti-Acne Cream 2-5%
Gel (Spot applicator) 4-6% Creamy Face Wash 2-4% Face pack 2-3%
AcNil DCx - Suggested Usage and Dosage
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CosmeVit DCx
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3. CosmeVit DCx
CosmeVit DCx is a power house of skin nutrients that supports a healthy and glowing skin with a multifaceted approach to skin lightening, skin moisturizing and skin protection.
CosmeVit DCx is generally recommended for
use in combination with core actives intended for the specific application.
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CosmeVit DCx - Ingredient Rationale
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Retinol / Vitamin A - Effective as an antioxidant, skin-cell regulator and helps skin repair
Vitamin E acetate - Stable form of Vitamin E, acts as a cell membrane protectant
Niacinamide / Vitamin B3 – Clinically validated to manage hyper pigmentation and moisture balance. It inhibits melanosome transfer to keratinocytes
Vitamin F - Linoleic acid and Linolenic acids well recognized to promote skin vitality
Ascorbyl glucoside - Stabilized form of Vitamin C with antioxidant benefits
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Nourishes skin with vital nutrients to make it bright and radiant Protects skin against harmful UV radiation
production Visibly lightens complexion Evens out skin tone
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CosmeVit DCx - Deliverables
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Range Dosage Form Dose Skin lightening Cream, Lotion, Translucent Serum 0.5-1% Depigmentation Cream 1-2% Anti-aging Cream, Translucent Serum 1-2% Anti-Wrinkle Cream 0.5-2% Anti-acne Cream, Face Wash 0.5-1% After Sun-care Creams and Lotions 0.5-1% Hair Care Creams 0.3-0.5%
CosmeVit DCx - Suggested Usage and Dosage
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CosmeVit DCx used in commercial formulation – Johara® PhytoBright™ Skin Lightening Range
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DermaSoothe DCx
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4. DermaSoothe DCx
Dermasoothe DCx is a composite of potent ingredients to replenish the skin’s natural moisture reserves and placate the skin naturally.
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DermaSoothe DCx - Ingredient Rationale
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Allantoin – A proven moisturizing, healing, anti-irritating, soothing nutrient
N-Acetyl Glucosamine – Helps preserve the natural moisture reserves of the skin
CovaFresh IV - Water soluble Menthyl lactate to offer cooling effects
Chamomile extract – Proven anti-irritant phytonutrients
Olive oil – Skin soothing oil
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Soothe and calm the skin Moisturizes to restore visibly healthier skin Helps calm minor skin itch / irritations
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DermaSoothe DCx - Deliverables
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Range Dosage Form Dose After Suncare Lotion, cream 1-3% Soothing - Calamine Lotion 1-3% Skin Care Shave and After shave cream or
Translucent Gel 2-3%
Hair Care Leave on Hair cream 2-3%
DermaSoothe DCx - Usage and Dosage
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DermaSoothe DCx used in commercial formulation – Glenmark’s Elosmooth™
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DerMoist DCx
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5. DerMoist DCx
DerMoist DCx is a balanced composite of proven nutrients that help to gently calm sensitive skin while keeping it moist, nourished and healthy.
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DerMoist DCx - Ingredient Rationale
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Cococin™ CG - Supports skin hydration and rejuvenation
Dexapanthenol – Helps maintain hydration balance
Hyaluronic acid- Potent moisturizer and humectant for dry skin
Zinc Gluconate – Boosts skin immunity
Jojoba Oil - Affords a protective sheath to the skin
Cococin™ U.S Patent No. 7,300,682 & 8,247,003. European Patent No. EP1341547. New Zealand Patent No. NZ598630. and NZ600307. Eurasian Patent No. EA20368
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DerMoist DCx – Human User Study
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*After using DerMoist DCx 3% Moisturizing Cream for 4 weeks by 20 volunteers (6 men and 14 women), during a study conducted by an independent agency
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Affords hydration of skin Moderate and modulate sebum production Improve skin immunity Support skin rejuvenation
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DerMoist DCx - Deliverables
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Range Dosage Form Dose Anti-acne Cream, Face Wash 5-15% Anti-aging Cream, Serum 5-10% Day Care Creams, Lotions 3-5% Skin conditioning Creams, Lotions 2-5%
DerMoist DCx - Usage and Dosage
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D’Heal DCx
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6. D’Heal DCx
D’Heal DCx is a scientifically validated composite of natural nutrients that provide a healing touch and soothe the skin while protecting it from microbial infections.
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D’Heal DCx - Ingredient Rationale
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Cococin™ CG - Supports skin hydration and promotes wound healing
Centellin® CG – Wound and scar management
Aloe vera – Clinically validated to promote wound healing and soothing
Allantoin – A proven moisturizing, healing, anti-irritating, soothing nutrient
Betaine Monohydrate - Helps strengthen skin barrier and maintain water-balance of the skin
1,2 Diols – Antimicrobial, hydration support
Chamomile extract – Proven anti-irritant phytonutrients
Cococin™ U.S Patent No. 7,300,682 & 8,247,003. European Patent No. EP1341547. New Zealand Patent No. NZ598630. and NZ600307. Eurasian Patent No. EA20368
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D’Heal DCx - In vitro study
Activity Result
MTT cell proliferation assay 24.15% cell proliferation at 50 µg/ml
SRB cell proliferation assay 21.50% cell proliferation at 50 µg/ml
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Promotes cell renewal and restores skin vitality Helps reduce inflammation Stimulates collagen production Prevents microbial infection Provides antioxidant support Gently nourishes the skin
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D’Heal DCx - Deliverables
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Range Dosage Form Dose Cuts/Burns & Wounds Cream 3-5% Cleansers Face wash 2-4%
Hand wash 3-5% Skin conditioning Creams, Lotions 2-5%
D’Heal DCx - Usage and Dosage
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KeraCon DCx
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7. KeraCon DCx
KeraCon DCx is composed of ingredients which helps to strengthen hair, promote hair growth and keeps the hair healthy and soft.
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KeraCon DCx - Ingredient Rationale
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Barley Beta Glucans - Helps to improve the hair vitality and protect it from environmental stressors
Caffeine – A phosphodiesterase inhibitor, helps prevent hair loss and also promotes hair growth
Betaine Monohydrate - Increase the moisture content of the hair, protects the scalp and produces brighter hair gloss
Trehalose – Moisture retention property
Cococin™ CG - Helps promote hair growth while moisturizing the scalp
Cococin™ U.S Patent No. 7,300,682 & 8,247,003. European Patent No. EP1341547. New Zealand Patent No. NZ598630. and NZ600307. Eurasian Patent No. EA20368
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KeraCon DCx - In vitro study
Activity Result
MTT cell proliferation assay 22.35% cell proliferation at 50 µg/ml
SRB cell proliferation assay 26.00% cell proliferation at 50 µg/ml
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Strengthens hair shaft Protects from hair shaft damage Protects hair from environmental stressors
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KeraCon DCx - Deliverables
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Range Dosage Form Dose Hair care Hair conditioner 5-8%
Shampoo 2-5% Conditioning Creams 1-2% Gels 1-2%
KeraCon DCx - Usage and Dosage
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MelaLite DCx
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8. MelaLite DCx
MelaLite DCx is a natural composite of melanin suppressors that helps to lighten the skin tone and eliminate pigmentation problems.
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MelaLite DCx - Ingredient Rationale
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pTeroWhite® - Potent melanogenesis inhibitor, UV protectant
Licorice Extract 40% CA – Potential tyrosinase and melanogenesis inhibitor
SabiWhite® - Clinically proven to be a safe and effective alternative to Hydroquinone for its skin lightening property
Tetrahydrocurcuminoids (SabiWhite®) U.S Patent No. 6,653,327. European Patent No. EP1171144 & EP1328263. New Zealand Patent No. NZ514884. Australian Patent No. AU2006235807
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MelaLite DCx - In vitro study
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0
20
40
60
80
100
Tyrosinase inhibition Melanogenesis inhibition
3.62 10.19 7
100
IC50
(µg/
ml)
Skin lightening potential of MelaLite DCx vs Kojic acid
MelaLite DCx Kojic Acid
Lower the IC50 value, higher the activity
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MelaLite DCx – Human User Study
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*After using MelaLite DCx 1% Skin Lightening Cream for 4 weeks by 20 volunteers (10 men and 10 women), during a study conducted by an independent agency
Users also reported an improvement in skin clarity, skin tone and glow on using MelaLite DCx cream.
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MelaLite DCx - Deliverables
Improves fairness to the skin Supports an even skin tone Nourishes skin to make it bright and radiant Protects skin against harmful UV radiation
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MelaLite DCx - Usage and Dosage
Range Dosage Form Dose Skin lightening Cream,Lotion,Serum 3-5% Depigmentation Cream 5-8% Anti-aging Cream, Serum 1-3% Sun care Cream, Lotions 1-2% After suncare Cream, Lotion 3-5%
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Application Focus D’Cosmix™ Skin firming AgeLess Complex DCx Skin regeneration AgeLess Complex DCx Skin conditioning CosmeVit DCx, DermaSoothe DCx Skin hydration DerMoist DCx Skin protection AcNil DCx, D’Heal DCx Skin calming DermaSoothe DCx, D’Heal DCx, AcNil DCx Skin nourishing DerMoist DCx
D’Cosmix™ – Application Areas.
Contd.,
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Application Focus D’Cosmix™ Skin energizing CosmeVit DCx Skin lightening MelaLite DCx, CosmeVit DCx Skin brightening MelaLite DCx Skin de-stress CosmeVit DCx Hair growth KeraCon DCx Hair fall control KeraCon DCx
D’Cosmix™ – Application Areas.
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D’Cosmix™ D’Cosmix is an intelligent integration of science and performance. D’Cosmix is suitable for use in a broad range of dosage forms that include creams, lotions, gels, serums, tonics and more.
D’Cosmix – The formulator’s choice
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THANK YOU www.sabinsa.com participating members of:
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