REFERENCES
Abuelo, J.G.2007. Normotensive ischemic acute renal failure. N. Engl. J. Med.,
357:795-797.
Acker, S.A., J. L.Tromp, D.H. Ginffoen and A. Bast. 1996. Structural aspects of
antioxidant activity of flavanoids. Free Rad Biology., 20:331-342.
Adzet, T., Camarasa, J., Laguna, J.C., 1987. Hepatoprotective activity of polyphenolic
compounds from Cynara scolymus against CCl4 toxicity in isolated rat hepatocytes. J.
Nat. Prod., 50: 612-617.
Agarwal, A. and S.A. Prabakaran. 2005. Mechanism, measurement and prevention of
oxidative stress in male reproductive physiology. Indian Journal of Experimental
Biology., 43: 963-974.
Agarwal, R.B and V.D. Rangari. 2003. Anti-inflammatory and anti-arthritic activities
of lupeol and 19a-H lupeol isolated from Strobilanthus callosus and Strobilanthus
ixiocephala roots. Indian Journal of Pharmacology., 35: 384-387.
Ahmed, R.S,V. Seth and B.D.Banerjee .2000. Influence of dietary ginger (Zingiber
officinale Rosc.)on antioxidant defense system in rat: comparison with ascorbic acid.
Ind. J. Exp. Biol., 38:604 606.
Ahmed,M.B and M.R. Khater. 2001. Evaluation of the protective potential of
Ambrosia maritime extract on acetaminophen- induced liver damage. Journal of
Ethnopharmacology., 75: 169 174.
Aibinu,I.,T.Adenikpekun, T.Adelowotan, S.Ogunsanya and Odugbemi. 2007.
Evaluation of the anti-microbial properties of different parts of Citrus aurantifolia
(Lime fruit) as used locally. African Journal of Traditional Complementary and
Alternative Medicines., 4: 185-190.
Aiyegoro, O.A. and A.I. Okoh.2010.Preliminary phytochemical screening and in vitro
antioxidant activities of the aqueous extract of Helichrysum longifolium DC.BMC
Complement.Altern. Med., 10: 1-8.
Ajami,M.,S. Eghtesadi, H. Pazoki-Toroudi, R. Habibey and S.A. Ebrahimi. 2010.
Effect of Crocus sativus on gentamicin induced nephrotoxicity. Biol Res., 43: 83-90.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Ajitha, M and K. Rajnarayana.2001. Role of oxygen free radicals in human diseases.
Indian Drugs., 38: 545 554.
Akah, P.A and A.I. Nwambie.1994. Evaluation of Nigerian traditional
medicines:Plants used for rheumatic (inflammatory) disorders. Journal of
Ethnopharmacology ., 42: 179-182.
Akindele, A.J and O.O. Adeyemi.2007.Antipyretic activity of Byrsocarpus coccineus
Schum and Thonn. (Connaraceae).International Journal of Pharmacology., 3:357-
361.
Ali , A.T., O.A. Swayeh, R.S. Al-Rashed, I.A. Al-Mofleh, A.D. Al-Dohayan, A.S. Al-
Tuwaijri.1996. Role of oxygen-derived free radicals on gastric mucosal injury
induced by ischemia- reperfusion.The Saudi Journal of Gastro-enterology., 2: 19-28.
Alkson, D.L and H.Rasmussen.1988.A spatial temporal model of cell activiation.
Science., 239:998-1005.
Amresh, G., P.N. Singh and C.V.Rao .2008. Toxicological screening of traditional
medicine Laghupatha (Cissampelos pareira) in experimental animals. J
Ethnopharmacol.,116: 454-460.
Amutha Priya D., S. Ranganayaki, P. Suganya Devi . 2011. Phytochemical screening
and antioxidant potential of Hybanthus enneaspermus: A rare ethano botanical herb.
J Pharm Res., 4 : 1497 1502.
Andrade, R.J., M.I. Lucena and M.C.Fernandez. 2005. Drug- Induced Liver Injury:
An analysis of 461 incidences submitted to the Spanish Registry over a 10-year
period. Gastroenterology., 129 : 512 521.
Andress, D.L. 2006. Vitamin D in chronic kidney disease: A systemic role for
selective vitamin D receptor activation. Kidney Int., 69: 33 43.
Anil Kumar. 2012. A review on hepatoprotective herbal drugs. International journal
of research in pharmacy and chemistry., 2:92-102.
Anisuzzaman, A.S.M., N. Sugimoto, G. Sadik, M.A.Gufor.2001. Sub-acute toxicity
study of 5-hydroxy-2 (hydroxyl-methyl) 4H-pyran-4-one, isolated from Aspergillus
fumigates. Pak J Biol Sci., 4:1012-1015.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Anonymous.1998.Withdrawl of medicinal products containing ebrotidine: liver
toxicity. WHO inform exchange system.1:72-73.
Ao, Y., K. Satoh, K. Shibano,Y. Kawahito and S.Shioda. 2008. Singlet oxygen
scavenging activity and cytotoxicity of essential oils from Rutaceae.J. Clin.
Biochem.Nutr., 43, 6-12.
Appenrodt, B., J. Zielinski, K.A.Brensing.2009. Degree of hepatic dysfunction and
improvement of renal function predict survival in patients with HRS type I: a
retrospective analysis. Eur J Gastroenterol Hepatol., 29:34-57.
Arky, T .1989.Hypoglycemia associated with liver disease and ethanol. Endocrinol
Metab Clin North Am., 18:75-90.
Arokiyaraj, K., P.Perinbam, R. Agastian and K.Mohan.2009. Phytochemical analysis
and antibacterial activity of Vitex agnus-castus. International Journal of Green
Pharmacy., 34:162-164.
Arroyo, V., P. Gines, A.L. Gerbes.1996. Definition and diagnostic criteria of
refractory ascites and hepatorenal syndrome in cirrhosis-International Ascites
Club. Hepatology., 23:164-76.
Arul Doss, V.K and P.T. Kalaichelvan. 2012. Invitro antimicrobial and antioxidant
activity screening of Andrographis paniculata Leaf ethanolic extract in Tamil Nadu.
Int J Pharma Pharmaceut Sci., 4: 227-229.
Arulkumaran, K.S., A. Rajasekaran, A.Ramasamy, M.Jegadee-san, S. Kavimani and
A. Somasundaram . 2009.Cassia rox-burghii seeds protect liver against toxic effects
of ethanol and carbon tetrachloride in rats. Int journal of pharm tech research.,1:273-
246.
Arulmozhi, S., P.M. Mazumder, P.Ashok and L. Sathiyanarayanan, 2010.
Pharmacological activities of Alstonia scholaris Linn.(Apocynaceae)-A review.
Pharmacog. Rev., 1: 163-170.
Arumugam, N.,S. Kandasamy and M.Sekar .2012. In-vitro antifungal activity of
Hybanthus enneaspermus F. Muell. Int J Pharm Pharmaceut Sci., 4: 594-596.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Arvind, S.,J.K. Negi Kumar, M.M. Karuna Shanker and S. Khanuja.2008. Recent
Advances in Plant Hepatoprotective: A Chemical and Biological Profile of Some
Important Leads. Medicinal Research Reviews., 28 : 746- 772.
Asha, V.V., S. Akhila, P.J. Wills and A. Subramoniam. 2004. Further studies on the
anti hepatotoxic activity of Phyllanthus maderaspatensis Linn. J Ethnopharmacol.,
92:67-70.
Asima Chatterjee Satyesh Chandra Prakashi and Block R.J.1992. The Treatise on
Indian Medicinal plants Vol.2, pp 150-151.
Asolkar, L.V., K.K. .Kakkar and O.J.Chakra. 1992. Second Supplement to Glossary
of Indian Medicinal Plants with Active Principle NISC, CSIR, New Delhi, India, pp:
265-266.
Asquith, T.N and L.G. Butler .1986. Interaction of condensed Tannins with selected
proteins. Phytochem., 25:591-1593.
Avijeet, J.,S.Manish, D.Lokesh, and K.L.Krishna. 2007. Antioxidant and
hepatoprotective activity of ethanolic and aqueous extract of Momordica dioica leaves
.J.Ethnopharmacol.,25:48-56.
Ayene, I.S., J.E. Biaglow, A.V. Kachur, T.D. Stamato and C.J. Koch.2008. Mutation
in G6PD gene leads to loss of cellular control of protein glutathionylation: mechanism
and implication. J. Cell. Biochem., 103: 123-135.
Bagchi, K. and S. Puri. 1998. Free radicals and antioxidants in health and disease,
Eastern Mediterranean Health Journal., 4 : 350-360.
Baker, H and O. Frank.1968. Determination of serum tocopherol. In: Gowenlock:
02-903.
Balasubramanian, R., J. Balasundaram, K. Subramanian and M. Narayanan. 2002.
Effect of dried fruits of Carica papaya Linn. on hepatotoxicity, Biol Pharm Bull.,
25: 1645-1646.
Barber, S.C. and P.J.Shaw.2010.Oxidative stress in ALS: Key role in motor neuron
injury and therapeutic target. Free Rad. Biol. Med., 48: 629-641.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Barham, J.B and M.B.Edens. 2000. Addition of eicosapentaenoic acid to gamma
linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in
humans. J Nutr., 130:1925 31.
Barker, S. B and W.H.Summerson. 1941. The colorimetric determination of lactic
acid in biological material. J. Biol. Chem.,138:535-554.
Basnet, P., K. Mastsushige, K.Hase, S.Kadota and T.Namba, 1996. Four Di-O-
coaffeoyl Qunic acid derivatives from propoils potent hepatoprotective activity in
experimental liver injury models. Biol.Pharm.Bull.,19: 1484-1487.
Bass, N.M. 2003. Drug-Induced Liver Disease. In: Friedman S, McQuaid K,
Grendell, J, eds. Current Diagnosis and Treatment in Gastroenterology. 2nd ed. New
York, NY: McGraw-Hill Professional. 664- 679.
Batsshaw, M.L.1994. Inborn errors of urea synthesis.Ann Neurol., 35:133-141.
Batt, A.M and L.Ferrari. 1995. Manifestations of chemically induced liver
damage. Clinical Chemistry. 41:1882-1887.
Battin, E.E. and J.L. Brumaghim. 2009. Antioxidant capacity of sulphur and
selenium: A review of reactive oxygen species scavenging, glutathione peroxidase,
and metal-binding antioxidant mechanism.Cell Biochem. Biophys., 55: 1-23.
Beartram, T and R.O. Recnagel.2005. Trends pharmacol sci., 4:129-134.
Beevi, S.S., M. L. Narasu and B.B. Gowda.2010. Polyphenolics profile, antioxidant
and radical scavenging activity of leaves and stem of Raphanus sativus L.Plant Foods
Hum. Nutr., 65: 8-17.
Bell ,J L and D.N.Boron.1960.A colorimetric method for determination of isocitrate
dehydrogenase.Clin Chim Acta.,5:740-747.
Bent, S and R.Ko.2004. Commonly used herbal medicines in the United States: a
review. The American Journal of Medicine.,116: 478-485.
Bentham G and J.D.Hooker. 1875. Genera Plantarum (Vol. I-III), Reeve and Co.,
Williams and Norgate, London.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Bergendi, L., L.Benes, Z. Durackova and K.Ferencik.1999 .Chemistry, physiology
and pathology of free radicals. Life Sci., 65: 1865-1874.
Bergmeyer, H.U., P. Scheibe, A.W. Wahlefeld.1978. Optimization of methods for
aspartate aminotransferase and alanine aminotransferase. Clin Chem., 24:58-73.
Bernal, W., N. Donaldson, D. Wyncoll and J. Wendon. 2002. Blood lactate as an
early predictor of outcome in paracetamol-induced acute liver failure: a cohort study.
Lancet., 359:558-563.
Bessems, J.G and N.P. Vermeulen. 2001. Paracetamol (acetaminophen)-induced
toxicity: molecular and biochemical mechanisms, analogues and protective
approaches. Crit Rev Toxicol ., 31: 55-138.
Bhadauria, A.2010. Exp Toxicol Pathol., 62: 627 635.
Bhadauria, M and S.N. Kumar .2009. Reversal of acetaminophen induced subchronic
hepatorenal injury by propolis extract in rats. Environ Toxicol Pharmacol.,27: 17 25.
Bhanuprakash Reddy,T., P. Muthenna, C. Akileshwari, N. Megha Saraswat and J.
Mark Petrash. Inhibition of aldose reductase and sorbitol accumulation by dietary
rutin. Current science 101: 1191-1197.
Bhattacharya, K., G. Alink and E. Dopp.2007. Oxidative stress and changed gene
expression profiles in fiber-particle-induced carcinogenesis. Int. J. Hum. Genet., 7:
1-21.
Bhattacharya, S and M.K. Zaman. 2009. Pharmacognostical evaluation of Zanthoxy
lumnitidum Root. Pharmacognosy Journal 1: 15-21.
Bickers, D.R and M.Athar.2006. Oxidative stress in the pathogenesis of skin disease.
J Invest Dermatol.,126:2565 75.
Blancho, C.D and S. Gentil. 1990.Alterations of glucose metabolism in chronic liver
disease. Diab Res Clin Prac., 8:29-36.
Blazka, M.E., J.L. Wilmer, S.D. Holladay and R.E. Wilson.1995. Role of
proinflammatory cytokines in acetaminophen hepatotoxicity. Toxicol Appl
Pharmacol., 133:43-52.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Block.G and L. Langseth.1994.Antioxidant vitamins and disease prevention. Food
Technol., 7:80 4.
Boericke, D.F and T.William.1998.Materia Medica and Repertory; Jain Publishing,
6th ed,124-125.
Bonacini, M., G. Hadi, S. Govindarajan, K.L. Lindsay. 1997.Utility of a discriminant
score for diagnosing advanced fibrosis or cirrhosis in patients with chronic hepatitis C
infection. Am J Gastroneterol ., 92: 1302-1304.
Bonfanti, P., S. Landonio, E. Ricci. 2001. Risk factors for hepatotoxicity in patients
treated with highly active anti-retroviral therapy. J. Adquir. Immune Defic Syndr., 27:
316 318.
Bonting,S.L.1970. Sodium-potassium activated adenosinetriphosphatase and cation
transport. In Membranes and Ion Transport. E. E. Bittar, editor. Interscience
Publishers, Ltd ., London . 1 :257.
Boominathan, R.,B.P.Devi and S.C.Mandal.2003. Insulin-secreting activity of the
traditional antidiabetic plant.Phytotherapy Research.,17:836- 838.
Boopathi, C.A. and R. Sivakumar, 2011. Phytochemical screening studies on the
leaves and stem of Andrographis neesianan wight-An endemic medicinal plants from
India. World. Appl. Sci. J., Pharmacognosy.,12: 307-311
Boots, A.W., G.R.Haenen and A. Bast .2008. Health effects of quercetin: from
antioxidant to nutraceutical. Eur J Pharmacol., 23:325-37.
Bosch, M.S. 2005. The role of -tocopherol in plant stress tolerance.J. Plant Physiol.,
162: 743-748.
Botsoglou, N. A., D.J. Fletouris, G.E. Papageorgiou, V.N. Vassilopoulos, A. Mantis
and A.G. Trakatellis. 1994. Rapid, sensitive and specific thiobarbituric acid method
for measuring lipid peroxidation in animal tissue, food and feedstuff samples. Journal
of Agricultural and Food Chemistry., 42:1931-1937.
Boveris, A., L.B. Valdez, T. Zaobomyj and J. Bustamante. 2006. Mitochondrial
metabolic states regulate nitric oxide and hydrogen peroxide diffusion to the cytosol.
Biochim.Biophys.Acta., 1757: 535 542.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Bradley, P.P., R.D.Christensen and G.Rothstein.1982. Cellular and extracellular
myeloperoxidase in pyogenic inflammation.Blood. , 60: 618-622.
Brown,R.A.1968.Hepatic and renal damage with paracetamol overdosage. J Clin
Pathol., 21:793-795.
Bulle, F., M.G.Mattei, S. Siegrist , A. Pawlak ,E. Passage and M.N, Chobert .1987.
Assignment of the human gamma-glutamyl transferase gene to the long arm of
chromosome 22.Hum. Genet., 76:283 286.
Burcham,P.C. and A.W. Harman, 1990. Mitochondrial dysfunction in paracetamol
hepatotoxicity: In vitro studies in isolated mouse hepatocytes. Toxicol.Lett., 50: 37-48.
Butterworth, R.F., J.F. Giguere, J. Michaud, J. Lavoie, G.P. Layrargues. 1987.
Ammonia: key factor in the pathogenesis of hepatic encephalopathy. Neurochem
Pathol., 6:1-12.
Cadenas, E. 1989.Biochemistry of oxygen toxicity.Annual Review of Biochemistry., 1:
58- 79.
Cadet, J.,T.Douki, J. Ravanat and R. Wagner.2012. Measurement of oxidatively
generated base damage to nucleic acids in cells: facts and artifacts. Bioanalytical Rev.
In press.
Cao, X.,S.V. Antonyuk, S. Seetharaman, L.J. Whitson, A.B.Taylor, S.P Holloway
and R.W. Strange. 2008. Structures of the G85R variant of SOD1 in familial
amyotrophic lateral sclerosis. J. Biol. Chem., 283: 16169 16177.
Capetenaki, Y.2008. Desmin cytoskeleton: a potential regulator of muscle
mitochondria behavior and function. Trends Cardiovasc. Med., 12: 339 348.
Catala, A. 2006. Lipid peroxidation of membrane phospholipids generates hydroxy-
alkenals and oxidized phospholipids active in physiological and/or pathological
conditions. Chem. Phys. Lipids., 157: 1-11.
Catherine, A., T. Rceo-Evans, J. Nicholas and G.Miller. 1997. Antioxidant properties
of phenolic compounds. Trends plant sci., 4: 152-159.
Center for Drug Evaluation and Research (CDER). 1996. Guidance for industry:
single dose acute toxicity testing for pharmaceuticals.1-2.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Centers for Disease Control and Prevention. 2012. Recommendations for the
identification of chronic hepatitis C virus infection among persons born during 1945-
1965. MMWR.,61:1-32.
Cerdan S., T.B. Rodrigues , A. Sierra ,M. Benito and L. Fonseca.2006. The redox
switch/ redox coupling hypothesis. Neurochem. Int.,48:523 530.
Chakraborty, P., S. Kumar,D. Dutta and V. Gupta.2009.Role of antioxidants in
common healthdiseases. Research J. Pharm. Tech., 2: 238-244.
Chanda, S.,K Nagani and J. Parekh.2010. Assessment of quality of Manilkara
hexandra (Roxb.) Dubard leaf (Sapotaceae): Pharmacognostical and Physicochemical
profile.Pharmacognosy Journal., 2: 520-524.
Chandan., B.K., A.K. Saxena, S. Shukla and B.Singh. 2007. Hepatoprotective
potential of Aloe barbadensis Mill.against carbon tetrachloride induced
hepatotoxicity.J Ethnopharmacol.,111: 560-566.
Chandramohan, N., A.S. Ebrahim, E.Babu and D.Sakthisekeran, 1996. In-vivo effect
of L-cysteine on ethanol-induced alterations in membrane-bound ATPases of liver
and kidney of experimental rats. J. Clin Biochem. Nutri.., 20:225-230.
Chandrashekar, K.S., K.S. Prasanna and A.B. Joshi. 2007.Hepatoprotective activity
of the Leucas lavandulaefolia on D (+) galactosamine induced hepatic injury in rats.
Fitoterapia., 78: 440-442.
Chanvitayapongs , S., B. Draczynska-Lusiak and A.Y. Sun. 1997. Amelioration of
oxidative stress by antioxidants and resveratrol in PC12 cells.Neuroreport ., 8:1499
1502.
d
Chaterjee, T.K.2000.Medicinal Plants with hepatoprotective properties, Herbal
Options, Books & Allied (P) Ltd., Calcutta, pp. 155.
Chattopadhyay, R.R. 2000. Possible mechanism of hepatoprotective activity of
Azadirachta indica leaf extract. J. Ethanopharmacol., 2:89: 217-219.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Chen, H., K. Lin, H.Huang, L. Tu and C. Lin, C. 2010.Terpenoids induces cell cycle
arrest and apoptosis from the stems of Celastrus kusanoi associated with reactive
oxygen species. J. Agric. Food Chem., 58: 3808-3812.
Cheng C. Y.,S. Y. Su ., N.Y.Tang ., T.Y. Ho., S.Y.Chiang .,C.L. Hsieh .2008. Ferulic
acid provides neuro protection against oxidative stress-related apoptosis after cerebral
ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats. Brain
Res., 13:136-50.
Chin, K.K., C.Colleen, T. Sutton, J.McCallum and G. Garibay.2008.Quantitative
determination of singlet oxygen generated by excited state aromatic amino acids,
proteins, and immunoglobulins. J. Am. Chem. Soc., 130: 6912 6913.
Chitravadivu, C., S. Manian and K. Kalaichelvi. 2009.Qualitative analysis of selected
medicinal plants, Tamilnadu, India. Middle-East J. Sci. Res., 4: 144-146.
Chiumiento, L and F.Bruschi.2009. Enzymatic antioxidant systems in helminth
parasites. Parasitol Res., 105, 593-603.
Chlopckiova,S.,J.Psotova, P. Miketova, J. Sousek, V. Lichnovsky and V.
Simanek.2004. Chemo protective effect of plant phenolics against anthracyclin
induced toxicity on rat cardiomyocytes. Phytotherapy Research., 18: 408-413.
Chopra, R.N., S.L. Nayar and I.C. Chopra.1956: In Glossary of Indian medicinal
plants, Council of Scientific and Industrial Research, New Delhi.1;197.
Christie, G.S and J.D. Judah. 1954.Mechanism of action of carbon tetrachloride on
liver cells. Proc R Soc Lond B Biol Sci., 90:241 257.
Chung, H., S. Hogan, L. Zhang, K. Rainey, and K. Zhou. 2007. Characterization and
comparison of antioxidant properties and bioactive components of Virginia soybeans.
J. Agr. Food Chem., 56:11515 11519.
Citoglu, G.S., H. Ozbek, B. Sever, H. Dulger and S. Ugras.2004. Hepatoprotective
and anti-inflammatory activities of Ballota glandulosissima. J Ethnopharmacol.,
95:143-149.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Clawson, G.A.1989. Mechanism of carbon tetrachloride hepatotoxicity.Pathology and
Immunopathology Research., 8: 104 112.
Clemens, M.R and H.D. Walker.1987. Lipid peroxidation in erythrocytes. Chem Phys
Lipids .,45: 251 268.
Colombini, M.P., F. Modugno, E. Ribechini.2010. Archaeometric data from mass
spectrometric analysis of organic materials: proteins, lipids, terpenoid resins,
lignocellulosic polymers and dyestuff. In Mass Spectrometry Handbook. Edited by
Lee M. Hoboken, NJ, USA: J. Wiley & Sons; 797-828.
Commission Directive.2003. Amending Directive 2001/83/EC of the European
compendium of 500 species, Orient Longman Pvt.Ltd.I:10-14.
Cooper, C.E., N.B.J. Vollard, T. Choueiri.2002. Exercise, free in the induction of
muscular lesions but also in the radicals and oxidative stress. Biochem Soc Trans .,
30: 23-25.
Corcoran, R.M and S.M. Durnan.1977.Albumin determination by modified
bromcresol green method.Clinical Chemistry .,23: 765-766.
Cornicelli, J.A.,B.K.Trivedi. 1999. 15-Lipoxygenase and its inhibition: a novel
therapeutic target for vascular disease. Curr. Pharm. Res., 5: 11-20.
Corpas, F.J., A. Fernández-Ocana, A. Carreras, R. Valderrama, and F. Esteban.2006.
The expression of different superoxide dismutase forms is cell-type dependent in
olive (Olea europaea L.) leaves. Plant Cell Physiol., 47:984-994.
Cragg, G.M. and J.N. David, 2001.Natural product drug discovery in the next
millennium.J. Pharm. Biol .,39: 8-17.
Cullen, J. M.2005.Mechanistic Classification of Liver Injury. Toxicol Pathol., 33:6 8.
Dai J and R.J. Mumper. 2010. Plant phenolics: extraction, analysis and their
antioxidant and anticancer properties. Molecules., 15 : 7313-7352.
Danan G and C.Benichou .1993.Causality assessment of adverse reactions to drugs. A
novel method based on the conclusions of international consensus meetings:
application to drug-induced liver injuries. J Clin Epidemiol., 46: 1323-1330.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Dapar, L.P., C.J. Aguiyi, N.N.Wannang, S.S.Gyang,M.N. Tanko. 2007. The
histopathologic effects of Securidaca longepedunculata on heart, liver, kidney and
lungs of rats. Afr J Biotechnol .,6: 591-595.
D'Archivio, M., C.Filesi and R.Di Benedetto. 2007. Polyphenols, dietary sources and
bioavailability. Annali dell'Istituto Superiore Di Sanita.,43:348 361.
Dass, S., S. K..Dash and S.N. Padhy.2004. Ethno botanical information from Orissa
state, India. A Review of Journal of Human Ecology .,14: 227.
Davidson,D.G.D and W.N. Eastham.1996. Acute liver necrosis following overdose
of Paracetamol. Br Med J., 2: 497 499.
Davis, G.L and J.R.Rodriguez.2001.Treatment of chronic hepatitis C in active drug
users. The new England Journal of Medicine., 345: 215-217.
Deepak, K.,G. Nayak, D. Rajalingam, P. Sengupta and K.Maity.2007. Evaluation of
hepatoprotective and antioxidant activity of Ichnocarpus frutescens on paracetamol-
induced heaptotoxicity in rats.Tropical J. Pharmaceut. Res., 6: 755-765.
De-Fatima, A., L.V.Modolo, L.S. Conegero, R.A. Pilli and C.V. Kohn. 2006.
Lactones and their derivatives: biological activities, mechanisms of action and
potential leads for drug design. Curr Med Chem .,13: 3371-3384.
Denninger M.H., 1999. Haemostasis in liver disease. In:Bircher J, J.P.Benhamou,
N.Mc Intyre, M.Rizzetto and J.Rodes (eds). Clinical hepatology, oxford university
press New York, 1795-1815.
Devi, P.R., S.K. Kumari and C. Kokilavani.2007. Effect of Vitex negundo leaf extract
Ind. J. Clin. Biochem., 22: 143-147.
Dewall, C. N., G. MacDonald, G.D. Webster, C.L. Masten, R.F. Baumeister and D.R.
Schurtz.2010.Acetaminophen Reduces Social Pain: Behavioral and Neural
Evidence. Psychological Science., 21: 931 937.
Dianzani, M.U., 1978. Biochemical aspects of fatty liver.In: Slatter
TF(ed).Biochemical mechanisms of liver injury, Acadamic Press, New York.45-96.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Dische, L and L.B Shettle .1948. A specific color reaction of methyl pentoses and a
spectrophotometric micromethod for their determination. J Biol Chem., 175, 595-603.
-
induced hepatic necrosis: A light and electron microscope and histochemical study. J.
Pathol.,116 :17 29.
Donnelly, P.J., R.M. Walker, and W.J. Racz.1994. Inhibition of mitochondrial
respiration In-vivo is an early event in acetaminophen-induced hepatotoxicity. Arch
Toxicol., 68: 110-118.
Drakin, D.L and J.H. Austin.1932.Spectrophotometric constants for common
hemoglobin derivatives in human, dog, rabbit blood. J Biol Chem., 98:719-68.
Drewnowski, A and C. Gomez-Carneros.2000. Bitter taste, phyto nutrients, and the
consumer: a review. Am. J. Clin. Nutr., 72: 1424 1435.
Curr.
Sci., 86: 37-41.
Dubey,G.P,A. Agrawal and S.P. Dixit.1994. Effect of Liv-52 on different biochemical
parameters in alcoholic cirrhosis. Antiseptic., 91:203- 205.
Dufor, D., A. Pichette, V. Mshvildadze, M. Bradette-Hebert S. Lavoie and J Legault.
2007. Antioxidant, anti-inflammatory and anti-cancer activities of methanolic extracts
from Ledumgroenlandicum Retzius. Journal of Ethnopharmacology., 111:22-28.
Dufour, D. R and L. Teot. 1998. Laboratory identification of ischemic hepatitis
(shock liver). Clin Chem ., 34:1287.
Durate, J., F. P.Vizcaino, P. Utrilla, J. Jimenez, J. Tamarago, A.Zarzuelo. 1993.
Vasodilatory effects of flavonoids in rat aortic smooth muscles Structure-activity
relationships. Gen. Pharmacol., 24:857-862.
Durham, A.E., K..C.Smith, J.R. Newton. 2003. An evaluation of diagnostic data in
comparison to the results of liver biopsies. Equine Vet J., 35:534-540.
Edeoga, H.O, D.E.Okwu and B.O. Mbaebie. 2005.Phytochemical constituents of
some Nigerian medicinal Plants. African Journal of Biotechnology .,4 :685-688.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
El-Hassan, H., K.Anwar, P.Macanas-Pirard, M.Crabtre and S.C. Chow. 2003.
Involvement of mitochondria in acetaminophen induced apoptosis and hepatic injury:
Roles of cytochrome C, Bax, Bid and caspases. Toxicol. Appl. Pharmacol., 191: 118-
129.
Ellman, G.L. 1986. Tissue sulphydryl groups. Archeives of Biochemistry and
Biophysics., 82: 70-77.
El-Mofty S. K., M.C. Scrutton, A. Serroni and C. Nicolini .1975. Early, reversible
plasma membrane injury in galactosamine- induced liver cell death. Am. J.
Pathol. 3:579 595.
Elson, L.A., W.T.J.Morgon. 1933. Colorimetric method for the determination of
glucosamine and galactosamine. Biochem J.,27:1824-1828
Eriksson, L.,U. Broome, M.Kahn and M.Lindholm.1992. Hepatotoxicity due to
repeated intake of low doses of paracetamol. Journal of Internal Medicine.,231:567-
570
Esterbauer, H.,R.J.R. Schaur and H. Zollner. 1991. Chemistry and biochemistry of 4-
hydroxynonenal, malonaldehyde and related aldehydes. Free Radical Biology and
Medicine., 11: 81 128.
Ezhilan ,B. P and R.Neelamegam.2012.GC-MS analysis of Phytocomponents in the
ethanolic extract of Poligonium chinensis L.Phcog Res.,4:11-14.
Fang,Y.Z., S. Yang and G. Wu 2002. Free radicals, antioxidants, and nutrition.
Nutrition., 18: 872 879.
Farnsworth, N.R., O. Akerele, A.S. Bingel, D.D. Soejarto and Z. Guo. 1985.
Medicinal plants in therapy. Bulletin of World Health Organization., 63: 965-981.
Faubion, W.A., M.E. Guicciardi, H. Miyoshi, S.F. Bronk , P.J.Roberts, and G.J.Gores,
1999.Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas.
Journal of Clinical Investigation., 103: 137-145.
Felig, P. W.,V. Brown, R. A. Levine and G. Klastkin, 1970. Glucose homeostasis in
viral hepatitis. N. Engl. J.Med., 283:1436-1440.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Fiske, H and Y.Subbarow 1925. The colorimetric determination of phosphorous.
J.Biol,.45:4-6.
Flower, R.,R. Gryglewski , K. -Cedro and J.R.Vane .1972.Effects of
anti-inflammatory drugs on prostaglandin biosynthesis.Nat New Biol .,238:104-6.
Foyer, C.H and G. Noctor .2005. Oxidant and antioxidant signalling in plants: a re-
evaluation of the concept of oxidative stress in a physiological context. Plant Cell
Environ., 28: 1056 1071.
Freeman ,B.A and J.D. Crapo.1982. Free radicals and tissue injury. Lab Invest ., 47:
412-426.
Fresco,P.,F.Borges, C. Diniz, M.P. Marques, M.P. 2006.New insights on the
anticancer properties of dietary polyphenols. Med. Res. Rev..,26: 747-766.
Friedberg, E.C, G.C. Walker and W. Siede. 1995. DNA repair and mutagenesis.
ASM Press, Washington, D.C.
Friedman, H., E.Scott, T. Grendell, H. James, R. McQuaid . 2003. Current diagnosis
and treatment in gastroenterology. New York: Lang Medical Books/McGraw-Hill.
664 679.
Friedman, T.E and G.F. Haugen . 1943. Pyruvic acid I. Collection of blood for the
determination of pyruvic acid and lactic acid. J. Biol. Chem. 144:67-77.
Friedwalds, W. T., R.T.Levy and D.S. Friedickson .1972. Estimation of concentration
of low density lipoproteincholesterol in plasma without use of the preparative
ultracentrifuge. Clin.Chem., 18:499-502.
Frings, C. S and R. T. Dunn, 1970.Lipids determination.Amer. J. Clini. Pathol., 53:
89-91.
Fuchs, S., V. Bogomolski-Yahalom , O. Paltiel and Z.Ackerman.1998. Ischemic
hepatitis: clinical and laboratory observations of 34 patients. J Clin Gastroenterol.,
26:183-186.
Galvez, J., M.E.Crespo, J. Jimmenez, A. Suarez, A. Zarzuelo, A. 1993. Anti-
diarrhoeal l activity of quercetin in mice and rats.J. Pharm. Pharmacol., 45: 157-159.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Genestra, M. 2007. Oxyl radicals, redox-sensitive signalling cascades and
antioxidants.Cellular Signalling., 19: 1807-1819.
Genovesi, S., D.M. Prata Pizzala , M.Pozzi , L. Ratti and M. Milanese .2009.
Baroreceptor sensitivity and baroreceptor effectiveness index in cirrhosis: the
relevance of hepatic venous pressure gradient. Liver Int., 28:56-78.
George, N.,T.P. Kumar , S.Antony, S. Jayanarayanan and C.S. Paulose .2012. Effect
of vitamin D3 in reducing metabolic and oxidative stress in the liver of
streptozotocin-induced diabetic rats. Br J Nutr., 108:1410-1414.
Geraldine, P.,T. Jayakumar and E. Ramesh.2006. Anti oxidant activity of the oyster
mushroom Pleurotus ostreatus on CCl4 induced liver injury in rats. Food Chem
Toxicol., 44: 1989-1996.
Ghai, C.L. 1993. A Textbook of Practical Physiology. Jaypee Brothers Medical
Publishers Ltd. India.
Ghani, A. 2003.Medicinal Plants of Bangladesh, Asiatic Society of Bangladesh,
Dhaka-1205.
Ghavami, S.,M. Hashemi,K. Kadkhoda ,S.M. Alavian , G.H.Bay and M. Los. 2005.
Apoptosis in liver diseases: detection and therapeutic applications. Med Sci Monit.,
11: 337 345.
Giftson, J.S.,S. Jayanthi and N. Nalini . 2010. Chemopreventive efficacy of gallic
acid, an antioxidant and anti-carcinogenic polyphenol, against 1,2-dimethyl hydrazine
induced rat colon carcinogenesis. Invest. New Drugs., 28: 251 259.
Gilbert, D.L.1981. Oxygen: An overall biological view. In: Oxygen and Living
Processes, Gilbert DL (Ed), Springer-Verlag, New York., p.376.
Gines, P., E. Quintero, V. Arroyo V. 1987. Compensated cirrhosis: natural history and
prognostic factors.Hepatology., 7:122-128.
Girish, C.,B.C.Koner,S. Jayanthi, K.R. Rao and B. RajeshPradhan.2009.
Hepatoprotective activity of six polyherbal formulations in paracetamol induced liver
toxicity in mice. Indian J Med Res., 129: 569-578.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Girish,C.,B.C. Koner, S. Jayanthi, K.R. Rao and B. RajeshPradhan.2009.
Hepatoprotective activity of six polyherbal formulations in paracetamol induced liver
toxicity in mice. Indian J Med Res., 129: 569-578.
Goebell, H and M. Stahler. 1963. Changes in alcohol dehydrogenase activity in rat
liver following protein deficiency and ethanol. Exp .biol.,13:68-74.
Goldberg, I.J and M.Merkel.2001. Lipoprotein lipase: physiology, biochemistry, and
molecular biology. Front Biosci., 6:388 405
Gonder, J.C. 2002. Regulatory compliance. In: Suckow MA, Douglas FA, Weichbrod
RH, eds. Management of Laboratory Animal Care and Use Programs. Boca Raton,
FL: CRC Press. p 163-185.
Gopal, G.V. and G.L. Shah, 1985.Some folk medicinal plants for jaundice in
Gujarat.India, J. Res. Indian Medicine, 4: 45-49.
Gopal, N and S. Sengottuvelu . 2008. Hepatoprotective activity of Clerodendrum
inerme against CCl4 induced hepatic injury in rats. Fitoterapia., 79:24-26.
Gopalakrishnan,C., L.Shankaranarayan,K. Kameswaran and S.Natarajan.1980. Effect
of tylophorine, a major alkaloid of Tylophora indica, on immune-pathological and
inflammatory reactions.Indian J., Med Res., 71:9-10.
Grabowski, G.A.and R.J.Hopkin. 2003. Enzyme therapy for lysosomal storage
disease: principles, practice, and prospects. Annu. Rev. Genomics Hum. Genet., 4:403-
436.
Gracanin, M.,C.L. Hawkins, D.I.Pattison and M.J.Davies.2009.Singlet-oxygen-
mediated amino acid and protein oxidation: formation of tryptophan peroxides and
decomposition products. Free Rad. Biol.Med., 47: 92-102.
Grawford, J.M. 2005.Liver and biliary tract. In: Kumar V, Abbas AK, Fausto N,
editors. Robbins and Cotran pathologic basis of disease. 7th ed. Philadelphia:
Elsevier. 877-937.
Gray , H and W.H. Lewis 2000. Gray's Anatomy of the Human Body.20th Ed. New
York, NY: Bartleby.pp123-133.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Green, D. R. and J.C. Reed.1998.Mitochondria and apoptosis.Science .,281: 1309-
1312.
Gross ,J.B., B.M.Myres and L.J.Kost.1989. Biliary copper excretion by hepatocyte
lysosomes in the rat-Major excretory pathways in experimental copper overload .J.
clin invest .,83:30-39.
Gudej, J and M. Tomczyk. 2004. Determination of flavonoids, Tannins, and ellagic
acid in leaves from Rubus L. species. Arch. Pharm. Res. ,27: 1114-1119.
Guha, G., V. Rajkumar, R.A. Kumar and L.Mathew.2009. Therapeutic potential of
polar and non-polar extracts of Cyanthillium cinereumIn vitro. eCAM, 1-11.
Guillouzo, A.,C. Clerc ,Y. Malledant , C. Chesne ,D Tatanasavanh and C.Gugen-
Guillouzo.1989.Modeles detudes de la cytoprotection technique, gastreinterol Clin.
Biol.,13 :45-52.
Gujarati, V.,N. Patel ,N.R. Venkat,K. Nandakumar, T.S.Gouda and M.D. Shalam.
2007.Hepatoprotective activity of alcoholic and aqueous extracts of leaves of
Tylophora indica (Linn.) in rats. Indian J Pharmacol ., 39:43-47.
Gulcin, I. 2011. Antioxidant activity of food constituents: an overview. Arch.
Toxicol., 86: 345-391.
Gulcin, I., O.L.Kufrevioglu, M.Oktay, M.E.Buyukokuroglu.2010. Antioxidant,antimi
crobial, antiulcer and analgesic activities of nettle (Urtica dioica L.). Journal o
f Ethnopharmacology .,90: 205 215.
Gupta, LM and R. Raina.1998.Side effects of some medicinal plants. Current
Science., 75:897-900.
Gupta, A.K and N. Misra.2006. Hepatoprotective activity of aqueous and ethanolic
extract of Chamomile capitula in paracetamol intoxicated Albino rats. Am J
Pharmacol & Toxicol., 1: 17-20.
Gupta, C., A.P. Garg and S. Gupta, 2010. Antimicrobial and phytochemical studies of
fresh ripe pulp and dried unripe pulp of Mangifera indica (AMCHUR). Middle-East J.
Sci. Res., 5: 75-80.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Gupta,M., K. Dobashi and J.K. Greene .1997.Studies on hepatic injury and
antioxidant enzyme activities in rat sub-cellular organelles following in vivo ischemia
and reperfusion. Mol Cell Biochem.,176:337 347.
Gupta,S.K and I.J.Singhvi.2011.Herbal and hepatoprotective drugs acting on peptic
ulcer and liver diseases:A Review .Int .Journal of pharm rech., 3:824-833.
Guyton, A.C and J.E. Hall.2001.Textbook of Medical Physiology.Tenth
Edition.Harcourt International Edition.Published by W.B. Saunders Company,
Philadelphia, Pennsylvania pp. 377-455.
Habig,W.H.,M.J.Pabst and W.B.Jacoby.1974. .Glutathione-S- Transferase. The first
enzymatic step in mercapturic acid formation.Journal of Biological chemistry ., 249:
130-139.
Halliwel, B and J.M.C. Gutteridge .1990. Free radicals in biology and
medicine.Second Edition Oxford, Clarendon Press., 1-20.
Halliwell, B and J.M.C. Gutteridge.1998.Free radicals, other reactive species and
disease. In: Free radicals in biology and medicine (Halliwell B, Gutteridge JMC, eds),
pp 617 784. Oxford: Oxford UP
Halliwell, B. M., A.Mulia, S.Chlrico, and O.I. Arouma, 1995. Free radicals and anto-
oxidants in food and invivo what they do and how they work. Critical Reveiws in
Food Science and Nurition.,35:7-20.
Han, X.Z., T. Shen and H. X. Lou.2007. Dietary polyphenols and their biological
significance.Int J Mol Sci., 8: 950 988.
Handa, S.S., Sharma, A and K.K. Chakraborthi.1986.Natural products and plants as
liver protecting agents. Fitoterapia., 5:307 351.
Hanson, L.O. and L. Lindquist.2005. C-reactive protein: Its role in the diagnosis of
and follow up of infectious diseases. Cur.Opin. Infect Dis., 10:196-201.
Harborne J. B. 1988.The Flavonoids. Chamman and Hall Publishing House, London,
1988.
Harsh Mohan. 2000.Textbook of Pathology, Jaypee brothers Medical Publishers Ltd.,
New Delhi .pp: 577-619.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Hase, K., J. Li, P.Basnet, Q.Xiong, S.Takamura, T.Namba and S.Kadota, 1997.
Hepatoprotective principles of Sweteria Japonica on D-galactosamine/
Lipopolysaccharide induced liver injury in mice. Chem Pharm Bull. ,45: 1823
1827.
Chemistry, Tata Mc-Grow Hill Publishing Co., New Delhi. pp. 499-508.
Hazra, B.,R. Sarkar,S. Biswas and N. Mandal.2010.Comparative study of the
antioxidant and reactive oxygen species scavenging properties in the extracts of the
fruits of Terminalia chebula, Terminalia belerica and Emblica officinalis.BMC
Complement.Altern. Med., 10: 1-15.
Hedge, J.E and B.T. Hofreiter. In: Methods in Carbohydrate Chemistry, (Eds.
Whistler,R.L. and Be Miller, J.N.), Academic Press, New York.
Hema, R.,S. Kumaravel,K. Alagusundaram.2011 . GC-MS Study on the bioactive
components and anti-cancer activities of Solanum surattense. Cancer Biol., 1: 13-17.
Hertog, M.G.L., D. Kromhout, C. Aravansis, H. Blackburn and M.B.Katan.1995.
Flavonoid intake and long-term risk of coronary heart disease and cancer in the Seven
Country Study. Arch Intern Med.,155: 381-386.
Heubi , J.E,C.C. Daugherty ,J.S. Partin ,J.C. Partin,W.K. Schubert . 1984.Grade
I Reye's syndrome- outcome and predictors of progression to deeper coma grades.N
Engl J Med., 311:1539-1542.
Hinson, H., N.R. Pumford and S.D. Nelson, 1983.The role of metabolic activation in
drug toxicity.Drug Metab., 26: 395-412.
Hinson, J.A.,A. B.Reid,S.S. Mcculloush and L.P. James.2004. Acetaminophen-
induced hepato toxicity role of metabolic activation reactive oxygen and
mitochondrial permeability trandition.Drug metabolism review.,36:805-822.
Hirose, Y., H. Takesada, S. Tanaka, T. Tamano and T .Shirai .1998. Carcinogenicity
of antioxidants BHA, caffeic acid, sesamol, 4- methoxyphenol and catechol at low
doses, either alone or in combination, and modulation of their effects in a rat medium-
term multi-organ carcinogenesis model. Carcinogenesis .,19 : 207 212.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Hjerten, S and H. Pan .1983. Purification and characterization of two forms of a low
affinity Ca2+ ATPase from erythrocyte membranes. Biochem Biophys Acta., 728:281-
288.
Hoffbrand, A.V and J.E.Pettit.1997. Essential of Heamatology 3rd edition, Blackwell
Science, pp 67-68.
Horborne, J.B.1973. Phytochemical methods, Champman and Hall Ltd. London,
pp.49-188.
Hu, C. and D.D. Kitts. 2000. Studies on the antioxidant activity of Echinacea root
extract. J. Agric. Food Chem.., 48: 1466-1472.
Huang, D.J., C.D. Lin, H.J. Chen and Y.H.Lin.2004.Antioxidant and anti-
proliferative activities of sweet potato (Ipomoea batatas Bot.
Bull. Acad. Sin., 45: 179-186.
Hudson E. A., P.A. Kokubun, T, Simmonds and M. S, Gescher.2000.
Characterization of potentially chemopreventive phenols in extracts of brown rice that
inhibit the growth of human breast and colon cancer cells. Cancer Epidemiol
Biomarkers Prev., 9: 1163-70.
Humanson. 1962. Animal Tissue Technique, San Francisco:WH Freeman and
Company, 2nd ed.136-137.
Hunter, E.B., P.E.Johnston, G.Tanner,C.W. Pinson and J.A.Awad.1999..Bromfenac
(Duract)- associated hepatic failure requiring liver transplantation. Am J
Gastroenterol., 94: 2299 - 2301.
Huy, L.P., H.G.He and C.P.Huy. 2008 Free radicals, antioxidants in disease and
health, Int. J. Biomed.Sci., 4:89-96.
Inc., USA.
Inoue, H., T.Yoshida, K. Abe , T. Ikeda , T. Matsushita , K. Wake and T. Sato 2007.
Inhibitory effect of Glycyrrhizin on lipo polysaccharide and D (+) galactosamine
induced mouse liver injury. Eur J Pharmacol., 576: 136-142.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Ishibashi, H., A. Komori, S. Shimoda and M.W. Gershwin. 2007. Guidelines for
Therapy of Autoimmune Liver Disease. Seminars in liver disease., 27: 2-5.
Ishida, Y., T.Kondo and H. Ohshima .2002. A pivotal involvement of IFN gamma
in pathogenesis of acetaminophen- induced acute liver injury. FASEB.,16:17-30.
Isselbacher, K.J and D.K. Podolsky. 1994. Approach to the patient with liver
disease,In: Isselbacher, K.J., Braunwald, E., Wilson, J.D., Martin, J.B., Fauci, A.S.
rinciples of Internal Medicine. 13th ed. Mc-
Graw Hill, Inc, New York, pp. 1437-1520.
Iwalewa, E.O., V. Naidoo, V. Bagla and J.N. Eloff.2009. Nitric oxide producing
effect of six extracts from Harungana madagascariensis Lam. ex Poiret (Guttiferae)
stem bark. Afr. J. Pharm. Pharmacol., 3:14-21.
Jaeschke, H., T.R. Knight and M.L. Bajt, 2003. The role of oxidant stress and reactive
nitrogen species in acetaminophen hepatotoxicity.Toxical.Lett., 144: 279-288.
Jaeschke, H.,G.J. Gores,A.I and A.Cederbaum. 2002. Mechanisms of
hepatotoxicity. Toxicological Sciences.,65: 166-176.
Janani, P., K.Sivakumari, A.Geetha, B.Ravisankar and C.Parthasarathy. 2010.
Chemopreventive effect of bacoside A on N-nitrosodiethylamine induced
hepatocarcinogenesis in rats, J. Cancer Res. Clin. Oncol., 136: 759-770.
Janbaz, K.H, S.A. Saeed and H. Gilani. 2004.Studies on the protective effects of
caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents.
Phytomedicine., 11:424-30.
Jang, M, L. Cai, G.O.Udeani, K.V. Slowing, C.V. Thomas. 1997.Cancer
chemopreventive activity of resveratrol, a naturalproduct derived from grapes.
Science ., 275: 218 20.
Jha Prajna, Jindal Richa and Chakraborty Dipiyoti. 2012. HPLC quantification of
phenolic acids fromVetiveria zizanioides (L.) and its antioxidant and antimicrobial
activity. Journal of Pharmaceutics.,103:34-45.
John, M.B.1972. In: Laboratory Medicine Hematology, Ed 4, CV Mosby Co., St
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Johnson, P.J. 1995. The assessment of hepatic function and investigation of jaundice.
In: Marshall W.J, S.K.Bangers (eds). Clinical Biochemistry: Metabolic and clinical
aspects, Churchill livingstone, New York, 217-236.
Jones, S., S. Sudweeks and J.L. Yakel. 2008. Radical-free biology of oxidative stress.
Am. J. Physiol. Cell Physiol., 60: 849-868.
Jones, G. 2007.Expanding role for vitamin D in chronic kidney disease: Importance of
blood 25-OH-D levels and extra-renal -hydroxylase in the classical and non-
classical actions of ,25-dihydroxyvitamin D3. Semin Dial ., 20: 316 324.
Jonker, D.,V.S. Lee , R.J.Hargreaves ,B.G. Lake . 1988.Comparison of the effects of
ascorbyl palmitate and L-ascorbic acid on paracetamol-induced hepatotoxicity in the
mouse.Toxicology.,52:287-95.
Jui, C., T.P.Reilly and M. Bourdi. 2002. Protective role of Kupffer cells in
acetaminophen induced hepatic injury in mice. Chem Res Toxicol.12: 1504- 1513.
Juraj Guzy and Zuzana Chovanova..2004. Effect of quercetin on paracetamol-
induced rat liver mitochondria dysfunction. Biologia Bratislava., 3:403-405.
Kakkar, P., B.Das and P.N.Vishvanathan. 1984. A modified Spectrophotometric assay
of SOD. Indian Journal of Biochemistry and Biophysics ., 21: 130-132.
Kamath, P.S and W.R. Kim.2007.The Model for End-Stage Liver Disease (MELD).
Hepatology., 10:1002- 1005.
Kamboj ,V.P. 2000. Herbal medicine. Current Science. 78: 35-39.
Kanabar, D and S. Dale . 2007. A review of ibuprofen and acetaminophen use in
febrile children and the occurrence of asthma-related symptoms. Clin Ther., 29:16-23.
Kaplan, A. 1984: Urea. Kaplan A et al. Clin Chem The C.V. Mosby Co. St Louis.
Toronto. Princeton; 1257-1260 and 437 and 418.
Kaplowitz ,N and L.D. Deleve, L.D. 2007.Drug-induced liver disease, 2nd edn,
Informa, New York.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Karadeniz, A., A.Yildirim, N. Simsek, Y. Kalkan and F. Celebi.2008.Spirulina
platensis protects against gentamicin-induced nephrotoxicity in rats. Phytother.Res.,
22: 1506-1510.
Kasper, D.L and E. Braunwald. 2005. Harrison's Principles of Internal Medicine, 16th
ed. McGraw-Hill Medical Publishing Division, New York.
Katalynic,V.,M. Milos ,T. Kulisic and M. Jukic.2006. Screening of 70 medicinal plant
extracts for antioxidant capacity and total phenols. Food Chem., 94: 550-553.
Kato K and S. Murota .1985. Lipoxygenase specific inhibitors inhibit murine
lymphocyte reactivity to Con A by reducing IL-2 production and its
action.Prostaglandins Leukot Med.,18:39-52.
Katsube, N., K.Iwashita , T. Tsushida ,K. Yamaki and M. Kobori. 2003. Induction of
apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins. J.
Agric. Food Chem., 51: 68- 75.
Kehrer, J.P and C.V. Smith. 1994. Free radicals in biology: sources, relativities, and
roles in the etiology of human diseases, In: Frei B. Natural Antioxidants in Human
Health and Disease, Academic Press, San Diego., 25-62.
Keshava Murthy, K.R. and S.N.Yoganarasimhan.1990.Flora of Coorg (Kedagu)
Karnataka, India pp.204.
Kew ,J., C.Morris and A. Aihic.1993. Arsenic and mercury intoxication due to
Indian ethnic remedies. BMJ., 306: 506-507.
Khandkar, M.A,D.V. Parmar ,M. Das and S.S.Katyare. 1996.Is activation of
lysosomal enzymes responsible for paracetamol-induced hepatotoxicity and
nephrotoxicity. J. Pharm. Pharmacol .,48: 437 440.
Kim, E., H. Lee, S. Moon,Y. Jeon, C.Ahn, and B. Jeaon. 2009. Free radical
scavenging activity by ESR spectroscopy and neuroprotective effect on H2O2-induced
damage in PC-12 cells of enzymatic extracts from Korean elk velvet antler. J. Food
Biochem., 33: 895-912.
Kimata M, Inagaki N, Nagai H.2000. Effects of luteolin and other flavonoids on IgE-
mediated allergic reactions. Planta Med., 66:25-29.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Kind, P.R.N and King, E.J.1954.Estimation of plasma phosphatase by determination
of hydrolysed phenol with amino-antipyrine. Journal of Clinical Pathology., 7: 322-
326.
King, J .1965. Lactate dehydrogenase In: King J, ed. Practical clinical enzymology,
van Norstand London., 87-97.
Kirtikar and Basu .1988 .Indian Medicinal plants Vo. 1. (2nd edin) PP 204.
Klaassen, C. D and J.B.Watkins.1984.Pharmacol. Rev., 36:1-67.
with acetaminophen ingestion: Report of a case and review of the literature.
Clin.Nephrol., 14: 201 205.
Kohlroser,J.,J.Mathai, B.F.Reichheld and H.L.Bonkovsky.2000. Hepatotoxicity due
to troglitazone: report of two cases and review of adverse events reported to the
United States food and drug administration. Am J Gastroenterol., 95: 272 - 276.
Kolchin, I.N., N.P.Maksiutina,P.P. Balanda, A.I. Luik, V.N.Bulakh, and
A.A.Moibenko.1991. The cardioprotective action of quercetin in experimental
occlusion and reperfusion of the coronary artery in dogs.Farmakol.Toksikol.,54: 20-
23.
Kon, K., J.S.Kim, H. Jaeschke and J.J.Lemasters.2004. Mitochondrial Konczak, I.
and W. Zhang, 2004.Anthocyanins-more than nature's colours. J. Biomed.
Biotechnol.,3: 239-240.
Konczak, I. and W. Zhang, 2004.Anthocyanins-more than nature's colours.J. Biomed.
Biotechnol.,3: 239-240.
Krisnaiah, D.,T. Devi, A.Bono and R.Sarbatly.2009.Studies on phytochemical
constituents of six Malaysian medicinal plants. J. Med. Plants Res., 3: 67-72.
Kulkarni,K.S.,M.D.Rafiq,S.Gopumadhavan,M.V.Venkataranganna,B.G.Madhumathi
and S.K. Mitra, 2002. Protective effect of Liv.52 on Na+-K+-ATPase activity in
paracetamol-induced hepatotoxicity. Med. Update., 5: 53-56.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Kumar, V.L,B.M. Padhy and A. Srivastava. 2007.Calotropis procera latex affords
protection against carbon tetrachloride induced hepatotoxicity in rats.J
Ethnopharmacol., 113: 498-502.
Kumar,V.,B.J.Gogoi, M.K. Meghvansi, L. Singh and C. Deka, D.C.
2009.Determiningthe antioxidant activity of certain medicinal plants of Sonitpur
(Assam), India using DPPH assay.J. Phytol.,1: 49-56.
Kupeli, E.,D.D. Orhan and E. Yesilada .2006.Effect of Cistus laurifolius L. leaf
extracts and flavonoids on acetaminophen induced hepatotoxicity in mice.J
Ethnopharmacol.,103:455-460.
Kyaw, A., T.Aung, T. Htut.1983.Lysosomal enzyme activities in normals and in
patients with chronic liver diseases. Clin Chim Acta.,131:317-323.
Lasser, K.E., P.D. Allen, S.J. Woolhandler, D.U. Himmelstein, and D.H. Bor. 2002.
Timing of new black box warnings and withdrawals for prescription medications.
JAMA., 287: 2215-2220.
Lee , W.M . 2003. Acute liver failure in the United States. Seminars in Liver Disease.,
23: 217-226.
Lemke ,T.K., D.A.William, V.E,Roche and
medicinal chemistry. Lippincot Williams and William, 253-325.
Lewis, J.H.2003. Nonsteroidal anti-inflammatory drugs: pathology and clinical
presentation of hepatotoxicity, in: Kaplowitz, N., DeLeve, L.D. (Eds.), Drug- Induced
Liver Disease, Marcel Dekker, New York, pp. 377 404.
Li, Y.and H.E.Schellhorn. 2007. New developments and novel therapeutic
perspectives for vitamin C. Critical Review, J. Nutr., 137: 2171-2184.
Li,W.,F.Shen and G. Weber.1999. Ribavirin and quercetin synergistically
downregulate signal transduction and are cytotoxic in human ovarian carcinoma cells.
Oncol. Res., 11: 243-247.
Liu, R.M. and K.A.G.Pravia.2010. Oxidative stress and glutathione in TGF- -
mediated fibrogenesis.Free Rad. Biol. Med., 48, 1-15.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Liyana pathirana, C.Mand F.Shahidi.2006.Antioxidants properties of commercial soft
and hard winter wheats (Triticum aestivum.L) and their milling fractions. Journal of
science of food and agriculture., 86: 477-485.
Lkhider, M., R. Castino,E. Bouguyon ,C. Isidoro ,M. Ollivier-
Bousquet.2004.Cathepsin D released by lactating rat mammary epithelial cells is
involved in prolactin cleavage under physiological conditions. J Cell Sci .,117: 5155
5164.
Loeb, L. A and S. Nishimura.2010. Princess Takamatsu Symposium on DNA Repair
and Human Cancers.Cancer Research .,70 : 4269 4273.
London, G.M., A.P. Guérin, F.H.Verbeke, B. Pannier, P. Boutouyrie , and S.J.
Marchais. 2007. Mineral metabolism and arterial functions in end-stage renal disease:
Potential role of 25-hydroxyvitamin D deficiency. J Am Soc Nephrol .,18: 613 620.
Longo, M.,A. Crosignani and M. Podda. 2001.Hyperlipidemia in Chronic Cholestatic
Liver Disease. Curr Treat Options Gastroenterol.,4:111-114.
Lopez-Revuelta, A., J.I. Sanchez-Gallego,A. Hernandez-Hernandez , J.Sanchez-
Yague and M. Llanillo.2006. Membrane cholesterol contents influence the protective
effects of quercetin and rutin in erythrocytes damaged by oxidative stress. Chem. Biol.
Interact. 161:79-91.
Lowry, O.H., N.J. Rosebrough, A.L. Farr, and R.J. Randall .1951.Protein
Measurement with the Folin Phenol Reagent.J. Biol. Chem., 193:265-275
Luper S. 1998.A review of plants used in the treatment of liver diseases.Altern Med
Rev., 3 : 410-421.
Madlener S., J. Svacinova , M. Kitner , J. Kopecky ,R. Eytner and G.Krupitza. 2009.
In vitro anti-inflammatory and anticancer activities of extracts of Acalypha
alopecuroidea (Euphorbiaceae). Int. J. Oncol., 35: 881-91.
Madlener S., J. Svacinova , M. Kitner , J. Kopecky ,R. Eytner and G.Krupitza. 2009.
In vitro anti-inflammatory and anticancer activities of extracts of Acalypha
alopecuroidea (Euphorbiaceae). Int. J. Oncol., 35: 881-91.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Malle, E., Furtmüller, P.G., Sattler, W. and Obinger, C. 2007 Myeloperoxidase: a
target for new drug development. Br. J. Pharmacol., 152: 838-854.
Malloy, H.T and K.A. Evlyn, 1937. The determination of bilirubin with the
photometric colorimetric.J.Biol. Chem., 119: 481-490.
Manach, C.,G.Williamson, C.Morand, A. Scalbert and C. Rémésy. 2005.
Bioavailability and bioefficacy of polyphenols in human: I. Review of 97
bioavailability studies. Am. J. Clin. Nutr., 81:230-242.
Mani, S.K.T., B. Gorain, D.K. Roy, A. Zothanpuia, S.K. Samanta, M. Pal, M. Biswas,
P.,Roy, A. Adhikari, D.Karmakar, S.Sen.2008. Anti-inflammatory activity of
Acanthus ilicifolius, J.Etnhopharmacol., 120: 7-12.
Manjunath Setty, V. B.,K.K.. Narayanaswamy, T.Sreenivasan and J. Annie
Shirwaikar. 2007.Free radical scavenging and Nephro protective activity of
Hybanthus enneaspermus (l) f. muell. Pharmacologyonline .,2: 158-171.
Mannervik, B and I. Carlberg.1985. Glutathione Reductase. Methods in Enzymology.,
113:484-490.
Manoukian, A.V and J.L. Carson.1996.Nonsteroidal anti-inflammatory drug-induced
hepatic disorders.Incidence and prevention.Drug Safety .,15: 64-71.
Marcos, S., O.Eliane,C. Ferreiraband U. Susanne.2006. Isolation and HPLC
Quantitative Analysis of Antioxidant Flavonoids from Alternanthera tenella Colla. Z.
Naturforsch., 61:19-25
Marinova, D., F.Ribarova and M.Atanassova. 2005. Total phenolics and total
flavonoids in Bulgarian Fruits and Vegetables. Journal of Chemical Technology and
Metallurgy., 40: 255- 260.
Markham, K.R.,B. Ternai ,R. Stanley ,H. Geiger ,J.J. Mabry T. 1978.Carbon-13 NMR
studies of flavonoids-III naturally occurring flavonoid glycosides and their acylated
derivatives. Tetrahedron.,34:1389-97.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Mathieu ,C and M. Jafari . 2006. Immunomodulation by 1,25-dihydroxyvitamin D3:
Therapeutic implications in hemodialysis and renal transplantation. Clin Nephrol.,
66: 275 283.
Mathur, R., S. Mathur and A. Prakash. 1993.Therapeutic efficacy of Liv-52 herbal
drug against beryllium toxicity. Int j of toxic Occup Envir Health .,2:75- 77.
Maton, T., C.Anthea and H.Jean Hopkins.1993.Human biology and health.Engle
wood cliffs, New Jersey, USA.Printice Hall.pp.189.
McGettigan, M.P and D. Henry .2000.Current problems with non-specific COX
inhibitors.Current Pharmaceutical Design., 6: 1693-1724.
McLean, A.1975. Models of liver diseases. In: Karger, B.A. (Ed.), New Trends in
the Therapy of Liver Diseases. S. Karger, Basel, pp. 2 12.
McNamara, B.1976. Concepts in Health Evaluation of Commercial and Industrial
Chemical. In: New Concepts in Safety Evaluation (Eds Mehlman MA, Shapiro RE,
Blumental H) Hemisphere, Washington DC, Vol. 1.Medicine
Mehler, A.H.,A. Kornberg ,S. Crisolia and S. Ochoa .1948.The enzymatic
mechanism of oxidation reduction between malate or isocitrate
pyruvate.J.Biol.Chem., 174: 961-977.
Mendenhall, C.L.1981. Cooperative Study Group on Alcoholic Hepatitis: Alcoholic
hepatitis. Clin Gastroenterol.,10: 417-441.
Meng, W.C.S., K.L. Leung, W.T.Leung and W.Y.Lau. 1999. Prospective randomized
control study on the effect of branched chain amino acids in patients with liver
resection for hepatocellular carcinoma. ANZ journal of Surjery ., 12: 811-815.
Menon, K.V.,G.J. Gores and V.H.Shah.2001. Pathogenesis, diagnosis, and treatment
of alcoholic liver disease .,76 :1021 1029.
Merken, H.M and G.R. Beecher.2000. Liquid Chromatographic method for the
Journal of
Chromatography., 897:177 18.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Messner, M.C.,C.J. Albert, F.F.Hsu and D.A.Ford.2006.Selective plasmenylcholine
oxidation by hypochlorous acid: formation of lysophosphatidylcholine
chlorohydrins.Chem. Phys. Lipids., 144: 34-44.
Miller, G., V.Shulaev and R.Mittler.2008.Reactive oxygen signaling and abiotic
stress.Physiol.Plant., 133: 481-489.
Mirochnitchenko, O., M. Weisbrot Lefkowitz, K. Reuhl, L. Chen, C. Yang and M.
Inouye. 2009. Opposite effect of two forms of glutathione. J. Biol.Chem., 11: 22 -28.
Mital Kaneria,Bhavana Kanani, Sumitra Chanda.2012. Assessment of effect of
hydroalcoholic and decoction methods on extraction of antioxidants from selected
Indian medicinal plants. Asian Pacific Journal of Tropical Biomedicine., 2:195-202.
Mitchell, J.R.,D. J. Jollow, W.Z. Potter,J.R. Gillette and D.D. Brodie.
1973.Acetaminophen-induced hepatic necrosis and protective role of glutathione. J
Pharmacol Exp Ther ., 187: 211-217.
Miyaguchi, S and M. Mori.2005.Ursodeoxycholic acid (UDCA) suppresses liver
interleukin 2 mRNA in the cholangitis model. Hepatogastroenterology., 52:596-602.
Mohamed Saleem T.S, Madhusudhanan Chetty C, Ramakanth S, Rajan V.S.T,
Mahesh Kumar K, Gauthaman K, 2010, Hepatoprotective Herbs-A Review,
Int.J.Res.Pharma.Sci. Vol-1, 1-5.
Mohandas, J., G.G.Duggin, J.S.Horvath and D.J.Tiller. Metabolic oxidation of
acetaminophen (paracetamol) mediated by cytochrome P-450 mixed-function oxidase
and prostaglandin endoperoxide synthetase in rabbit kidney.1981. Toxicol. Appl.
Pharmacol. 61: 252 259..
Monier, D and S .R .Wagle. 1971. Studies on gluconeogenesis in galactosamine
induced hepatitis . Proc. Soc .Exp .Biol .Med .,136 :377-379.
Moore, M., H. Thor, G. Moore, S. Nelson, P. Moldeus,and S. Orrenius, 1985. The
toxicity of acetaminophen and N-acetyl P-benzoquinoneimine in isolated hepatocytes
is associated with thio depletion and increased cystosolic Ca2+.J. Biol. Chem.,
260:13035-13040.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Moreira, A.S.,V. Spitzer, E. Schapoval and E.P. Schenkel. 2000. Anti-inflammatory
activity of extracts and fractions from the leaves of Gochnatia polymorpha.Phytother.
Res.,14: 638-640.
Moriya ,K., K.Nakagawa and T. Santa . 2001.Oxidative stress in the absence of
inflammation in a mouse model for hepatitis C virus associated hepatocarcinogenesis.
Cancer Res.,61: 4365-70.
Mukharjee PK. 2005. Quality Control of Herbal Drugs: An Approach to Evaluation of
Botanicals.India: Business Horizones. 5:521-523.
Mukherjee, K.L .1989. Medical Laboratory Technology Tata McGraw Hill Publishing
Company limited, New Delhi, 1st ed., 3-1124.
Muriel P.1997. Peroxidation of lipids and liver damage. In: Antioxidants, oxidants
and free radicals, Baskin SI and Salem H, ed. Washington, DC: Taylor and Francis;
pp. 237.
Muriel, P.1995.Interferon alpha preserves erythrocyte and hepatocyte ATpase
activities from liver damage induced by prolonged bile duct ligation in the
rat.J.Appl.Toxico.,15:449-453.
Murray ,R.L and A. Kaplan .1984. Creatinine.Clin Chem ., 1:1261-66.
Murray J. C., J.A.Burch, R.D. Streilein , M.A. Iannacchione, R.P. Hall and S.R.
Pinnell. 2008. A topical antioxidant solution containing vitamins C and E stabilized
by ferulic acid provides protection for human skin against damage caused by
ultraviolet irradiation. J. Am. Acad. Dermatol., 59, 418-25.
Musa, K.Y, A.U. Katsayal ,A. Ahmed,Z. Mohammed and U.H. Danmalam
2006.Pharmacognostic investigation of the leaves of Gisekia pharnacioides. African
Journal of Biotechnology ., 5: 956-957.
Mustafa Tuzen.,Z. 2003. Chromatographic Determination of Phenolic Acids in the
Snowdrop by HPLC.Turk. J. Chem., 27: 49-54.
Nagendrappa, C.G.2005. An appreciation of free radical chemistry, free radicals in
diseases and health.Resonance.,10:65-73.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Namasivayama, N.,S.K. Rajagopala,P. Manickam and V. Periyasamy .2003.Activity
of Cassia auriculata leaf extract in rats with alcoholic liver injury. J Nutr
Biochem.,14: 452-458.
Nandagopal, S. and B.D. Ranjitha Kumari, 2007.Phytochemical and antibacterial
studies of Chicory (Cichorium intybus L.)-A multipurpose medicinal plant. Advan.
Biol. Res., 1(1-2): 17-21.
Nathiya, S and R.Senthamil Selvi.2013.Antifertility effect of Hybanthus
enneaspermus against endosulphan induced toxicity in male rats. Int.
J.Med.Biosci.,2:28-32.
Navarro Nunez, T., M. Palomo,C.Martínez, V.Vicente, J. Castillo, O. Benavente-
García. 2008. Apigenin Inhibits Platelet Adhesion and Thrombus Formation and
Synergizes with Aspirin in the Suppression of the Arachidonic Acid Pathway. J.
Agric. Food Chem.., 56 : 2970-2971.
Navayath Sushma and Thiyagarajan Devasena, 2010. Human and experimental
toxicology., 29: 311-9.
Ndhala, A.R., A.Kasiyamhuru, C. Mupure, K.Chitindingu, M.A.Benhura and
M.Muchuweti.2007.Phenolic composition of Flacourtia indica, Opuntia megacantha
and Sclerocarya birrea. Food Chem.,103: 82 87.
Neibes, P.1972, Determination of enzymes and degradation products of
glycosaminoglycan metabolism in healthy and various subjects. Clin. Chim Acta.,
42 : 399 408.
Neill, S.J.,R. Desikan , A. Clarke and J.T. Hancock .2007. Nitric oxide signalling in
plants.New Phytol., 159: 11-35.
Nelson,S.D.1990. Molecular mechanisms of the hepatotoxicity caused by
acetaminophen.Semin Liver Dis.,10:267 278.
Newman ,D.J, G.M.Cragg and Snader K.M.2000. The influence of natural products
upon drug discovery. Naural Product Reports 17: 215-234.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Newman, D.J and G.M.Cragg.2007. Natural products as sources of new drugs over
the last 25 years.Journal of Natural Products .,70: 461-477.
Nichans,S and B.Samuelson.1968. Formation of malondialdehyde from phospholipids
arachidonate during microsomal lipid peroxidation. European Journal of
Biochemistry., 6 :126-130.
Niebes, P. 1972. Determination of enzyme and degradation in products of
glycosaminoglycans metabolism in serum of healthy and varicose subjects. Clin
Chim Acta., 42: 399-408.
Nigam ,S and T.Schewe .2000. Biochim.Biophys.Acta., 1488: 167-181.
Niki,E. 1987. Ann. N. Y. Acad. Sci. ,498: 186-199.
Nikkila, E.A., M.R. Taskinen, S.Rehman and T.Sane 1978. Metabolic and endocrine
control it plasma high density lipoprotein concentration. Relation to catabolism of
triglyderide rich lipoproteins. Metabolism.,2:1661-1665.
Noctor, G and G.H. Foyer. 1998. Ascorbate and glutathione: keeping active oxygen
under control. Annu Rev Plant Physiol Plant Mol Biol., 49: 249 279.
Node, K., M. Kitakaze, H. Yoshikawa, H. Kosaka and M. Hori. 1997.Reversible
reduction in plasma concentration of nitric oxide induced by cigarette smoking in
young adults. American Journal of Cardiology., 79:1538-1541.
Noguchi, C and E. Nikki.2000. Phenolic antioxidants: A rationale for design and
infants. Antioxidants and redox signaling., 6: 169-176.
of prognosis in fulminant hepatic failure. Gastroenterology., 97:4439-4445.
Oboh, G. and J.B.T. Rocha.2007. Water extractable phytochemicals from Capsicum
pubescens (tree pepper) inhibit lipid peroxidation induced by different pro-oxidant
agents in brain: In Vitro. Eur. Food Res. Technol., 226, 707-713.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
OECD. 2010. Guidance Document on the Validation and International Acceptance of
New or Updated Test Methods for Hazard Assessment, OECD Series on Testing and
Assessment No. 34, OECD, Paris.
Ohinishi T, T. Suzuki, Y.Suzuki and K.A.Ozawa 1982.Comparative study of plasma
membrane Mg2+ ATPase activities in normal, regenerating and malignant cells.
Biochem Biophys Acts.,684: 67-74.
Ohkawa, H., N. Ohishi and K. Yagi. 1979. Assay for lipid peroxides in animal tissues
by thiobarbituric acid reaction. Anal. Biochem., 95: 353 358.
Ohnishi, T., T. Suzuki and K.Ozawa.1982. A comparative study of plasma membrane
magnesium ion ATPase activities in normal, regenerating and malignant cells.
Biochem.Biophys.Acta., 684: 67 74.
Ojo ,O. O.,O. Ladeji .2005. Hepatoprotective and antioxidant effects of Camellia
sinensis (Black tea) in rats.Afr. J.Biotechnol..,4 : 1432-1438.
Okamoto, T., K. Kajino and O. Hino. 2001. Hepatoprotective drugs for the treatment
of virus induced chronic hepatitis: From hyper-carcinogenic state to hypo-
carcinogenic state. Japanese Journal of Pharmacology. 87: 177-178.
Olaleye, M.T. and B.T.Rocha.2008.Acetaminophen-induced liver damage in mice:
effects of some medicinal plants on the oxidative defense system. Exp. Toxicol.
Pathol., 59: 319-327.
Olthof , M.R.,P.C. Hollman ,M.B.Katan . 2001.Chlorogenic acid and caffeic acid are
absorbed in humans. J. Nutr.,131: 66 71.
Orrenius, S., H. Thor, G. Bellomo, and D. Moldeus, 1984. Glutathione and tissue
toxicity.In: paton W, Mitchell, J., Tumer p.(eds) proceedings of the 9th International
congress of pharmacology, Macmillian Press, London. 37- 48.
Ostapowicz, G.,R.J. Fontana, F.V. Schiodt.2002. Results of a prospective study of
acute liver failure at seventeen tertiary care centers in the United States. Ann Intern
Med., 137:947-954.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Oviasogie, P.O., D. Okoro and C.L. Ndiokwere. 2009.Determination of total
phenolic amounts of some edible fruits and vegetables. Afr. J. Biotechnol., 8: 2819-
2820.
Oyaizu, M. 1986.Studies on products of browning reaction: anti-oxidative activities of
products of browning reaction prepared from glucosamine. Jpn. J. Nutr., 44:307-
315.
Oyedemi, S.O., G.Bradley and A.J.Afolayan. 2010. In -vitro and -vivo antioxidant
activities of aqueous extract of Strychnos henningsii Gilg, Afr. J. Pharm. Pharmacol.,
4:70-78.
Ozbek H., S. Ugra, H. Dulger, I. Bayram, I. Tuncer, G. Ozturk, and A. Ozturk .2003
Hepatoprotective effect of Foeniculum vulgare essential oil. Fitoterapia., 74: 317-
319.
Pacher, P., J.S. Beckman and L. Liaudet.2007. Nitric oxide and peroxynitrite in
health and disease, Physiol. Rev., 87: 315-424.
-lipoic acid as a biological
antioxidant. Free Radical Biology and Medicine., 19: 227-250.
Padayatty ,A.,Y. Katz .P. Wang,O.. Eck, P. Kwon, and O. Eck. 2003. Vitamin C as
an Antioxidant: Evaluation of Its Role in Disease Prevention. J Am Coll Nutr. 22:
18-35.
Paget, G.E. and Barnes, J.M. 1983. Evaluation of Drug Activities, In: Laurence, D.R.
and Bacharach, A.L. (Eds.), Pharmacometrics, Academic Press, London. Vol. 1,
p. 115.
Paliwal, A., R.K.Gurjar and H.N. Sharma.2009. Analysis of liver enzymes in albino
rat under stress of - cyhalothrin and nuvan toxicity. Biol Med.,1: 70-73..
Pan, Y., Z. Zhu,Z. Huang, H.Wang, Y. Liang, K.Wang and M. Liang. 2009.
Characterization and free radical scavenging activities of novel red pigment from
Osmanthus fragrans seeds. Food Chem., 112: 909-913.
Pang S., X. Xin, M.V. Stpierre . 1992. Determinants of metabolic Disposition. Ann
Rev Pharmacol Toxicol., 32: 625-627.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Panovska, T.K., S. Kulevanova, I. Gjorgoski, M. Bogdanova and G. Petrushevska.
2007. Hepatoprotective effect of the ethylacetate extract of Teucrium polium L.
against carbon tetrachloride induced hepatic injury in rats. Acta Pharm.,57: 241-248.
Paranthaman, R., P. Praveen kumar and S. Kumaravel . 2012.GC-MS Analysis of
Phytochemicals and Simultaneous Determination of Flavonoids in Amaranthus
caudatus (Sirukeerai) by RP-HPLC. J Anal Bioanal Techniques., 3:1-4
Paresh,C.D and L. Normen.1998.Capillary column gas liquid chromatographic
- unsaturated and saturated phytosterols. Journal of
Chromatography., 816: 177 1.
Parmar, D.V.,G. Ahmed, M.A. Khandkar and S.S. Katyare, 1995. Mitochondrial
ATPase: A target for paracetamol induced hepatotoxicity. Eur. J. Pharmacol., 293:
225-229.
Pascucci, M.W and D.W. Grisley 1983. Electroimmuno assay of albumin in human
serum: accuracy and long-term precision. Clin Chem ., 29:1787-1790.
Patel DK, Kumar R, Prasad SK, Sairam K, Hemalatha S. 2011.Antidiabetic and in
vitro antioxidant potential of Hybanthus enneaspermus (Linn) F. Muell in
streptozotocin-induced diabetic rats. Asian Pacific Journal of Tropical
biomedicine.,14: 316-322.
Patrice Jomnang, S and V. Francoise Benoit.2007.Are West African plants a source
of future antimalarial drugs. J. Ethnopharmacol., 114: 130-140.
Pauli-Magnus, C.,B. Stieger, B. Meier, Y. Kullak-Ublick and P.J. Meier. 2005.
Hepatol., 43: 342-357.
Pavana, P., S.Sethupathy and S. Manoharan. 2007. Antihyperglycemic and antilipid
peroxidative effect of Tephrosis purpura seed extract in streptozotocin induced
diabetic rats.Ind. J. Clin. Biochem., 22: 77-83.
Pepys, M.B and G.M.Hirschfield. 2003. C-reactive protein: a critical update. J. Clin.
Invest.,111: 1805 12.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Pereira,C.,K. Mapuskar and C.V. Rao . 2010. Chronic mixture toxicity study of
Clophen A60 and diethyl phthalate in male rats. Toxicol Environ Chem.,90:349 359.
Perry, N.B., E.J. Burgess,V.L. Glennie.2001: Echinacea standardization: analytical
methods for phenolic compounds and typical levels in medicinal species. J. Agr. Food
Chem., 49: 1702 1706.
Pessayre, D., B.Fromenty, A. Mansouri , A. Berson . 2007. Hepatotoxicity due to
mitochondrial injury, in: Kaplowitz N., DeLeveL.D. (Eds), Drug- induced liver
disease, 2nd edn. Informa Healthcare, New York, pp. 49 84.
Peterson, G. M. and M. Naunton. 2011. Safety of ibuprofen vs.paracetamol. British
Journal of Clinical Pharmacology ., 71: 964.
Pharmacopoeia of India (the Indian Pharmacopoeia).1996. 3rd edn. Government of
India, New Delhi: Ministry of Health and Family Welfare,56-68.
Pignatelli,,P., F.M.Pulcinelli, A.Celestini, L. Lenti, A. Chiselli, P.P.Gazzaniga, F.
Violli, 2000. The flavonoids quercetin and catechin synergistically inhibit platelet
function by antagonizing the intracellular production of hydrogen peroxide. Am. J.
Clin. Nutr.,72: 150-1155.
Poli G.2000. Pathogenesis of liver fibrosis: role of oxidative stress. Mol Aspects Med.,
21: 49 98.
Polit, E.S., M. Drezkiwicz and Z. Krupa. 2009. Lipid peroxidation and anti-oxidative
response in Arabidopsis thaliana exposed to cadmium and copper. Acta Physiol.
Plant.,32: 169-175.
Poole , A and G.B.Leslie .1989. A Practical Approach to Toxicological Investigations
1st edition, Great Britain, Cambridge University Press Vol. 2, p. 30-117.
Pourmorad, F., S.J. Hosseinimehr and N. Shahabimajd.2006. Antioxidant activity,
phenol and flavonoid contents of some selected Iranian medicinal plants. African
Journal of Biotechnology.,5: 1142-1145.
Prabhadevi, V., S. Sahaya Sathish ,M. Johnson ,B. Venkatramani and N. Janakiraman.
2012.Phytochemical studies on Allamanda cathartica L. using GC-MS.Asian Pacific
Journal of Tropical Biomedicine.,20:550-554.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Prakash ., S and Y.K. Joshi.2004.Assesment of micro-nutrients, antioxidants, total
antioxidant capacity and lipid peroxidation levels in liver cirrhosis.Asian
pacif.J.clin.nutri., 1:13-15.
Premalatha, B. and P. Sachidanandam, 1998. Immunomodulatory activity of
Semecarpus anarcadium Linn.nut milk extract in aflatoxin B1.Induced hepatocellular
carcinoma in rats. Pharm Pharacol commu.,4: 507-510.
Prieto, P., M.Pineda and M.Aguilar.1999.Spectrophotometric quantification of
antioxidant capacity through the formation of phosphomolybdenum complex:
specific application of vitamin E. Anal. Biochem., 269: 337 341.
Pulla Keddy, A.C.H and H.R. Lokesh. 1994. Effects of dietary turmeric (Curcuma
longa ) on iron induced lipid peroxidation in the rat liver. Fd Chem Toxic., 32: 279 -
283.
Pumford,N. R.,N.C. Halmes and J.A.Hinson.1990.Covalent binding of xenobiotics to
specific proteins in the liver. Drug Metab. Rev., 29: 39 57.
Rabe, T. and J.V. Staden.1997. J .Ethnopharmacol.,56: 81-87
Radhika, S., K.H. Smila and R. Muthu Ezhilan . 2011.Cardio-protective Activity of
Hybanthus Enneaspermus (Linn.) on Isoproterenol Induced Rats. Indian Journal of
Fundamental and Applied Life Sciences., 3: 90-97.
Radwan, M.A.2000.Zidovudine, diclofenac and ketoprofen pharmacokinetic
interactions in rats.Journal of Pharmacy and Pharmacology ., 52: 665-669.
Raforth, R.J and G.R. Onstad .1975.Urea synthesis after oral protein ingestion in
man.J Clin Invest.,56: 1170 74.
Raghavendran, H.R.B.,A.Sathivel and T.Devaki. 2005. Effect of Sargassum
polycystum (Phaeophyceae)-sulphated polysaccharide extract against acetaminophen-
induced hyperlipidemia during toxic hepatitis in experimental rats. Mol. Cell.
Biochem., 27 : 89 96.
Rajakaruna, N., C.S. Harris and G.H.N. Towers.2002. Antimicrobial activity of plants
collected from Serpentine outcrops in Sri Lanka. Pharm Biol .,40 : 235-244.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Rajib Ahsan, K M., A. Monirul Islam and E. Haque.2009.Hepatoprotective activity of
Methanol extract of some medicinal plants against CCl4 induced hepatotoxicity in
rats. Gl. J. Pharmacol.,116- 122.
Ramachandra Setty, S., A.A. Quereshi and A.H. Viswanath Swamy. 2007.
Hepatoprotective activity of Calotropis procera flowers against paracetamol-induced
hepatic injury in rats. Fitoterapia., 78:451-454.
Rana, S.V.S., and S. Kuamr, 1988.Curr. Sci. 57: 1259.
Rao, D.B.,C.H. Kiran,R. Madhavi, P.K. Rao and T.R.Rao.2009 Evaluation of
antioxidant potential of Clitoria ternatea L. and Eclipta prostrate L. Indian J.
Biochem. Biophys., 46: 247-252.
Rappaport, A.M.1976. The microcirculatory acinar concept of normal and
pathological hepatic structure.Beirr Path., 157 :214- 21 5.
Raskin, I., D.M. Ribnicky, S. Komarnytsky, N. Ilic, A. Poulev, N. Borisjuk and A.
Brinker.2002.Plants and human health in the twenty-first century.Trends in
Biotechnology., 20: 522-531.
Recknagel ,R.O and E.A.Glende 1973. Carbon tetrachloride hepatotoxicity: An
example of lethal cleavage. CRC Crit Rev Toxicol .,2:263-97.
Record, C.D. and K.G.Albentini.1972. Metabolic studies in experimental liver disease
resulting from D-Galactosamine administration. Biochem.J. ,130: 37-440.
Reddy., K and G. Sudarsanam and P.G.Roa.1989.Plant drugs of chitoor district in
Andhra Pradesh. India. Ind. J .crude drug. res., 27:41-54.
Reicks ,M.M and D. Crankshaw.1993. Effects of D-limonene on hepatic microsomal
monooxygenase activity and paracetamol-induced glutathione depletion in mouse,
Xenobiotica., 23: 809-819
Reitman, S and S.Frankel. 1957. A Colorimetric method for the determination of
serum glutamate oxaloacetic glutamatic pyruvic transaminase. Americal Journal of
clinical pathology., 28 : 56-63.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Ren, W.Y., Z.H. Qiao, H. W. Wang, L. Zhu and L. Zhang. 2003. Flavonoids:
promising anticancer agents. Med. Res. Rev., 23: 519 534.
Repetto, M.G and S.F. Llesuy. 2002. Antioxidant properties of natural compounds
used in popular medicine for gastric ulcers. Braz. J. Med. Biol. Res., 35: 523-534.
Retnam, K.R and A. J. De Britto .2003. Phytochemical analysis of a medicinal plant
Hybanthus enneaspermus (L) F. Muell.J. Econ. Taxon. Bot.,27: 701-706.
Robards, K. and M. Antolovich. 1997. Analytical chemistry of fruit bio-
Analyst .,122: 11 34.
Roe, J.M and C.A.Keuther.1972.Detection of Ascorbic acid in whole blood and
urine through the 2, 4-dinitro phenyl hydrazine derivative of de- hydro ascorbic acid.
Journal of biological chemistry .,147 : 399-407.
Roitelman, J.,E.H. Olender, S.Bar-Nun, W.A. Dunn and R.D. Simoni. 1992.
Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-
methylglutaryl coenzyme A reductase: implications for enzyme degradation in the
endoplasmic reticulum. J. Cell Biol.,117 : 959 73.
Rolandi, E., R. Franceschini, A. Cataldi, V. Cicchetti, L. Carati and T. Barreca.1991.
Effects of ursodeoxycholic acid (UDCA) on serum liver damage indicesin patients
-blind controlled study. Eur JClin
Pharmacol., 40: 473-6.
Rosalki, S.B and D. Rau. 1972. Serum gamma glutamyl transpeptidase activity in
alcoholism. clinical chemical acta ., 39: 41-47.
Rosenberg, P., H. Urwitz, A. Johannesson. 2007. Psoriasis patients with diabetes
mellitus type II are at high risk of developing liver fibrosis during methotrexate
treatment. J. Hepatol., 46: 1111 1118.
Ross,M. H., L.J. Romrell and G.I. Kaye.1996. Histology a text & atlas,(William &
Wilkins, Baltimore), Ist ed, 65-78.
Rotruck,J.T.,A.L.Pope,H.Gauther,H.andA.B.Swanson,.1973.Selenium:Biochemical
roles as a component of Glutathione peroxide. Science., 179:588-590.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Rukkumani, R.., K. Aruna ,P. Suresh Varma and M.Padmanabhan .2004.
Hepatoprotective role of ferulic acid: a dose-dependent study. J Med Food., 7:456-61.
Runyon, B.A.,H.N. Canawati ,E.A. Akriviadis.1988. Optimization of ascitic fluid
culture technique. Gastroenterology.95:1351-1355.
Saad, B., H.Azaizeh ,G. Abu-Hijleh and O. Said.2006. Safety of traditional Arab
herbal. Evid Based Complement Alternat Med ., 3: 433 9.
Saba, A.B.,A.A. Oyagbemi and H.Azeez 2010, Antidiabetic and haematinic effects of
Parquetina nigrescens on alloxan induced type- diabetes and normocytic
normochromic anaemia in wistar rats. Afr.Health Science., 276-282, 10, 3.
Sabir, S.M and J.B.T.Rocha .2008.Antioxidant and hepatoprotective activity of
aqueous extract of Solanum fastigiatum -
induced liver damage in mice.J Ethnopharmacol.,120: 226 232.
Sahoo, S.,D.M. Kar, S. Mohapatra, S.P. Rout and S.K. Dash. 2006. Anti-bacterial
activity of Hybanthus enneaspermus against selected urinary tract pathogens. Indian
journal of pharmaceutical sciences.,5 : 653-655.
Sahreen,S.,M.R.Khan and R.A.Khan.2010. Evaluation of antioxidant activities of
various solvent extracts of Carissa opaca fruits. Food Chem.,122: 1205-1211.
Saini,A., S.Sharma ,and S. Chhibber.2009. Protective efficacy of Emblica officinalis
against Klebsiella pneumoniae induced pneumonia in mice. Ind. J. Med.
Res.,128:188-193.
Sakaguchi, S., N. Kanda, C.C. Hsu, C.C. Sakaguchi, HSU, and J.Abe, 1981.Effect of
- tocopherol on endotoxicosis.Microbial Immunol.,25:787-799.
Sampath Kumar ,K and N.Ramakrishna.2011. Phytochemical and GC-MS Analysis
of Naringi crenula (Roxb.) Nicols. Stem. Bot Res Inter., 4: 9-12.
Sanchez-Venegas, J.R., J. Dinamarca, A.G.Moraga and M. Gidekel, M. 2009.
Molecular characterization of a cDNA encoding Cu/Zn superoxide dismutase from
Deschampsia Antarctica and its expression regulated by cold and UV stresses, BMC
Res. Notes, 2, 1-7.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Santra, A., A. Maity, A. Choudhury and D.N. Guha Mazumdar. 2000.Oxidative stress
in liver of mice exposed to arsenic contaminated water. Indian J Gastro enterol.,19:
1-2.
Sapolsky, A. I., R.D. Altman, J.F. Woessner and D.S. Howell .1973. J. Clin. Invest.,
52, 624-63.
Sarantchandra, G, J, S.Chandre, P. Jayasuder and B.Murthy 1996. Toxicology of
cleistanthus collinus an indigeneous plant acute toxicity study .Indian J. Toxicol.,3: 9-
17.
Saraswathi, U and N. Nithya.2009 Evaluation of radical scavenging effect of Limonia
acidissimia, Electronic Journal of Pharmacology and Therapy., 2: 55-57.
Sarkar, A., S.Dash, B.K. Barik, M.S.Muttigi, V. Kedege, J.K. Shetty and
M.Prakash.2010) Copperand ceruloplasmin levels in relation to total thiols and GST
in type 2 diabetes mellitus patients. Ind. J. Clin.Biochem., 25:74-76.
Sathish, T.K., S.Shanmugam, T. Palvannan and V.M. Bharathi. 2007. Evaluation of
antioxidant properties of Canthium parviflorum Lam. Leaves. Natural Product
Radiance., 7: 122-126.
Satyavati, G.V.,A.K.. Gupta and N. Tandon .1987. Medicine plants of India, vol. 2.
New Delhi: Indian Council of Medical Research,pp 567-568.
Savitha, S., J.Tamilselvan,M. Anusuyadevi and C.Panneerselvam.2005. Oxidative
stress on mitochondrial antioxidant defense system in the aging process: role of DL-
alpha-lipoic acid and L-carnitine. Clin Chim Acta ., 355: 173-180.
Schwarz, B.C., R.V. Hoven and I. Schwendenwein.2011.Diagnostic value of the
neutrophil myeloperoxidase index in horses with systemic inflammation. Vet J 33:
42-49.
Scollan, N.D.,R.J. Dewhurst,A.P. Mononey and J.J.Murphy.2005. Improving the
quality of products from grassland, Grassland: A Global Resource, Proc XX Int
Grassl Cong., pp. 41-56.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Seifter, S., S.Dayton,B. Novic and E.Muntwyler.1950. The estimation of glycogen
with anthrone reagent.Arch. Biochem., 25 : 191-200.
Selvamangai,G and S. Anusha Bhaskar.2012. GC-MS analysis of phyto-components
in the methanolic extract of Eupatorium triplinerve.Asian Pacific Journal of Tropical
Biomedicine.,147: 1329-1332.
Sen, J ., K. Tilrget and F. Ilatipoglu .2001.Evaluation of ultra monographic and
morphological liver changes in dogs with steroid hepatopathy. Indian Ver J.,
586- 589.
Sen, S., R. Chakraborty and J. Mazumder. 2009. Plants and phytochemicals for peptic
ulcer: an overview.Pharmacognosy Reviews., 3 : 270-279.
Sengottuvelu, S.,R.Duraisamy, J. Nandhakumar and T. Sivakumar. 2007.
Hepatoprotective activity of Cleome viscose against carbon tetrachloride induced
hepatotoxity in rats. Phcog Mag., 3: 120-123.
Seufi, A.M., S.S.Ibrahim, T.K. Elmaghraby and E.E. Hafez.2009. Preventive effect of
flavonoid and quercetin, on hepatic cancer in rats via oxidant/antioxidant activity:
molecular and histological evidences.J.Exp. Clin. Cancer Res., 28:78- 80.
Shah, S.N and M.P.Anand, M.P.2003. API, Text Book of Medicine, 7th edition,
Published by The Association of Physicians of India, Mumbai, 625-626.
Shallom,M and S. Katyare.1988. Altered Cerebral Protein Turnover in Rats Following
Prolonged In Vivo Treatment with Nicotine. Journal of Neurochemistry., 50:1356
1363.
Sharma, M.C. and S. Sharma, 2010. 28. Harbone, J.B., 1973. Phytochemicals
methods antimicrobial activity of Eclipta albaand Morinda Citrifolia L. Middle-East
J. Sci. Res., 6(5): 445-449.
Sheikh, N.M., R.M.Philen, L.A. Love. 1997. Chaparral-associated
hepatotoxicity. Arch Intern Med., 157:913-919.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Shieh, P.,Y. Chen, D. Kuo, F. Chen,M. Tsai, I. Chang and M.Pan.2010.Induction of
apoptosis by [8]-Shogaol via reactive oxygen species generation, glutathione
depletion, and caspase activation in human leukemia cells. J. Agric. Food Chem., 58:
3847-3854.
Shimizu Y.1969. Effect of carbon tetrachloride administration on the synthesis of
triglycerides and phospholipids in rat liver. J Lipid Res.,3:479-86.
Shreedhara, C.S and V.P. Vaidya. 2006.Screening of Momordica dioica for
hepatoprotective, antioxidant and anti inflammatory activities. Nat Prod Sci., 12:
157-161
Shukla, S., A. Mehta,P. Mehta, S.P. Vyas, S. Shukla , V.K.Bajpai 2010. Studies on
antiinflammatory, antipyretic and analgesic properties of Caesalpinia bonducella F.
seed oil in experimental animal models. Food and Chemical Toxicology .,48: 61-64.
Siddique,N.A.,M.Mujeeb,A.K. Najmi and M. Akram.2010.Evaluation of antioxidant
activity, quantitative estimation of phenols and flavonoids in different parts of Aegle
marmelos. Afr. J. Plant Sci., 4: 1-5.
Simeonova, P.P, R.M. Gallucci, T. Hulderman and R. Wilson. 2001. The role of
tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by
carbon tetrachloride. Toxicol Appl Pharmacol.,177: 112 120.
Singer.,AJ, T.R. Carracio, H.C. Mofenson. 1995. The temporal profile of increased
transaminase levels in patients with acetaminophen-induced liver dysfunction. Ann
Emerg Med., 26:49-53.
Singhal, A.K., V.S.Bhati,V.K. Singhal.2010.Pharmacognostic study of aerial parts of
plant Geniosporum prostratum (L) Benth. J Sci Specul Res ., 1: 19-24.
Sinha, A.K. 1972 . Colorimetric assay of catalase. Analytical Biochemistry., 47: 389-
394.
Skoutakis, V.A.,C.A. Carter, T.R. Mickle, V.H.Smith, C.R. Arkin, C.R.
Alissandratos, J. Petty .1988. Review of diclofenac and evaluation of its place in
therapy as a nonsteroidal anti-inflammatory agent. Drug Intelligence and Clinical
Pharmacy ., 22: 850-859.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Slater,E.C and W.D. Borner.1952.The effect of fluoride on the succinic oxidase
system. Biochem J.,52:185 196.
Sohini, V.S. and S. Rana. 2007. Protective effect of ascorbic acid against oxidative
stress induced by inorganic arsenic in liver and kidney of rat. Indian J. Exp. Biol., 45:
371-375.
Song, X. and W. Zhang.2006.Growth inhibition effect on parthenolide on
hepatocellular carcinoma cell line BEL-7402.Chem. Res., 22, 173-176.
Souza, A.D., T.B. Kurien, R. Rodgers,J. Shenoi, S. Kurono, H. Matsumoto,K.
Hensley S.K. Nath and R.H. Scofield.2008. Detection of catalase as a major protein
target of the lipid peroxidation product 4-HNE and the lack of its genetic association
as a risk factor in SLE.BMC Medical Genetics., 9:60- 62.
Stahl , J. 1963.Studies of the blood ammonia in liver disease. Its diagnostic,
prognostic and therapeutic significance. Ann Intern Med., 58:1 24.
Sturgill MG, Lambert GH. Xenobiotic-induced hepatotoxicity: mechanisms of liver
injury and methods of monitoring hepatic function Clin Chem. 1997 Aug; 43(8 Pt
2):1512-26.
Subash, S and P.Subramanian.2009. Morin a flavonoid exerts antioxidant potential in
chronic hyperammonemic rats: a biochemical and histopathological study. Mol. Cell
Biochem., 327: 153-161.
Subramoniam, A and P.Pushpangadan. 1999. Development of phytomedicines for
liver diseases. Indian J Pharmacol ., 31: 166-175.
Sudarsanam G and Sivaprasad G .1995.Medical Ethnobotany of Plants used as
Plants, pp. 57-65
Sudhahar,V., S.A. Kumar, P. Varalakshmi and R. Sundarapandiyan. 2007. Mitigating
role of lupeol andlupeol linoleate on hepatic lipemic-oxidative injury and lipoprotein
peroxidation in experimental hypercholesterolemia. Mol. Cell. Biochem., 295: 189-
198.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Sur,T.K., D.Bhattacharyya,S. Pandit, U.Jana and S. Sen, S.2005. Hepatoprotective
activity of Adhatoda vasica aqueous leaf extract on D (+) galactosamine induced liver
damage in rats. Fitoterapia., 76: 223-225.
Suresh Kumar, S.V. and S.H. Mishra, 2006.Hepatoprotective activity of extracts from
Pergularia daemia (Forsk.) against carbon tetrachloride-induced toxicity in
rats.Pharmacog Magazine.,3: 187-191.
Sushma, S.,S. Dasarathy, R.K. Tandon .1992. Sodium benzoate in the treatment of
acute hepatic encephalopathy: a double-blind randomized trial. Hepatology. 16:138-
44.
Susin, S.A.,N. Larochette, M.Geuskens, G.Kroemer . 2000. Purification of
mitochondria for apoptosis assays. Methods Enzymol.,322: 205-208.
Szekanecz, Z and A.E.Koch.2004.Therapeutic inhibition of leukocyte recruitment in
inflammatory diseases.Curr Opin Pharmacol ., 4:423-428.
Tabassum, N and S.S. Agrawal . 2004. Hepatoprotective activity of Eclipta alba
Hassk. against paracetamol induced hepatocellular damage in mice.Exp Med JK-
Pract.,11:278-280
Tabrez, S and M.Ahmad.2009.Some enzymatic/non-enzymatic antioxidants as
potential stress primarkers of trichloroethylene, heavy metal mixture and ethyl alcohol
in rat tissue, Wiley Periodicals Inc.,pp.1-10.
Taguchi,K.,Y.Hagiwara,K.Kajiyama,Y.Suzuki.1993.Pharmacological studies of
Houttuyniae herba: the anti-inflammatory effect of quercitrin. Yakuga Zasshi .,113:
327-333.
Tamilmozhi, M., S.Swarnalatha and P.Sakthivel.2013.Anti-allergic and analgesic
effect of ariel parts of Hybanthus enneaspermus.International research journal of
pharmacy.,4:243-248.
Tan, P.V, C. Mesui ,G. Enow-Orock, N.Njikam ,T. Dimo and P.Bitolog P 2008.
Teratogenic effects, acute and sub chronic toxicity of the leaf aqueous extract of
Ocimum suave Wild (Lamiaceae) in rats. Journal of Ethnopharmacology .,115: 232-
237.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Tanaka, M., E.Misawa, N. Itoy Habana and R. Inagaki . 2000. Identification of
phytosterol from Aloevera gel as antidiabetic compounds.Biol.pharm bull., 29:1418-
1422.
Tanira, M.O.M., Ageel, A.M., Tariq, M., Mobsin, A. and Shah, A.H. 1988.Evaluation
of some pharmacological, microbiological and physical properties of Zizyphus
spinachristi. International Journal of Crude Drug Research, 26:56-60.
Teo, S., D. Stirling , S. Thomas , A. Hoberman , A.Kiorpes and V. Khetani.2002. A
90-day
Terao, J., M.Piskula and Q. Yao.1996. Protective effect of epicatechin, epicatechin
gallate, and quercetin on lipid peroxidation in phospholipid bilayers.Arch. Bichem.
Biophys. 308:278-284.
Testa, B and Jenner, P.1981.Inhibition of cytochrome P-450s and their mechanism of
action. Drug Metabolism Review ., 12:1-17.
Thames,G. 2004.Drug-induced liver injury: what you need to know. Gastroenterol
Nurs., 27: 31-33.
Thanga Krishna Kumari,S.,M. Packia Lincy, S. Muthukumarasamy and V. R.
Mohan.2012.Anti- inflammatory activity of sarcostemma secamone (l) bennet whole
plant against carrageenan induced paw edema . Bioscience Discovery ., 3: 288-291.
The Ayurvedic Pharmacopoeia of India 2008.1st ed. Government of India, Ministry of
Health and Family Welfare, Department of Ayush, New Delhi.
Thiers, R.E and E.S. Reynolds.1958. Effects of carbon tetrachloride intoxication on
distribution of metals in subcellular fractions of rat liver. Fed.Proc., 17:535- 537.
Thiruvengadam D., R.K. Vilwanathan and S.S. Kanchi . 2005.Hepatoprotective
activity of Tridax procumbens against D(+) galactosamine/lipopolysaccharide
induced hepatitis in rats. J Ethnopharmacol., 101: 55-60.
Thomas, C.E., E. Kalyanaraman.1997.Oxygen radicals and the Disease Process.
Harwood Academic Publishers, The Netherlands.23-24.
Thomson, A. 1994 .In The Cytokine Handbook (eds K.J. Tracey) , Academic Press
Limited, London, pp.290-300.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Thresiamma , K.C and R. Kuttan.1996. Inhibition of liver fibrosis by ellagic acid.
Indian J Physiol Pharmacol., 40: 363-366.
Tiegs ,G. M, A.Wolter and A. Wendel, 1989. Tomor necrosis factor is a terminal
mediator in galactosamine / endotoxin induced hepatitis in mice.
Biochem.Pharmacol., 38: 628 631.
Timbrell, J.A. 1991. Drug Hepatotoxicity.Br. J. Clin. Pharmacol., 15: 3-14.
Tiwari, S .2008. Plants: a rich source of herbal medicine. Journal of Natural
Products., 1: 27-35.
Toklu ,H.Z.,A.O. Sehirli ,A. Velioglu-Ogünç A, Cetinel S, Sener G.2006.
Acetaminophen toxicity is prevented by beta D-glucan treatment in mice.Eur J
Pharmacol., 14:133-40.
Toniutto, P., C. Fabris,D. Bitetto, E. Fornasiere, E. Fumolo and R. Rapetti.
R.2008.Antiviral treatment in patients with hepatitis C virus-related cirrhosis awaiting
liver transplantation. Ther Clin Risk Manag.,4: 599 603.
Tortora, G.J and B.D. Derrickson.2006 .Principles of anatomy and physiology, 12th
ed., John Wiley & Sons, USA.pp1203-1206.
Tosulkao, C. and T.Glinsukon, 1992. Hepatic LPT in Lipid soluble Antioxidants:
Biochemistry and clinical applications.Ong. A.S.H. and packer, l. (eds) Birkauses
Verllag, Switzerland.567-574.
Traber, M. G., R.J.Sokol, S.P. Ringel, H. Neville and C.A.Thellman.1987. Lack of
tocopherol in peripheral nerves of vitamin E-deficient patients with peripheral
neuropathy.N. Engl. J. Med. 317:262-265.
Trauner, M., P.J. Meier and J.L.Boyer.1998. Molecular pathogenesis of cholestasis.
New England Journal of Medicine.,339: 1217-1227.
Trease, G.E. and W.C. Evans, 1989. Pharmacology 11th Edn., Bailliere Tindall Ltd.,
London, pp: 60-75.
Trifunovic, A and N. G. Larsson. 2008. Mitochondrial dysfunction as a cause of
ageing (Review).J. Intern. Med., 263:167-178.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Trinder, P. 196). Determination of triglycerides. Ann Clin .Biochem., 6: 24-7.
Tripathy, S.,P. Sahoo, D. Pradhan, D., Sahoo and D. Satapathy.2009. Evaluation of
anti arthritic potential of Hybanthus enneaspermus.African Journal of Pharmacy and
Pharmacology. , 2: 611-614.
Trump, B.F., E.M. McDowell and A.U.Arstila.1980. Cellular reaction to injury. In:
Principles of Pathobiology, 3rd Ed, RB Hill Jr, MF LaVia, (Eds.), Oxford University
Press, New York, NY, 20-111.
Turkseven, S.,A. Kruger, C.J. Mingone, C.J., Kaminski, P., Inba, M., Rodella, L.F.,
Ikehara, S., Wolin, M.S.and Abraham, N.G. (2005) Antioxidant mechanism of heme
oxygenase-1 involves as increase in superoxide dismutase and catalase in
experimental diabetes. Am. J. Physiol. Heart Circ. Physiol., 289: 701-707.
Ueno, H., M.Kawai, H. Shimokawa, M. Hirota, M.Ohmi. 2009.Synthesis and
structure-activity relationships of oxamyl dipeptide caspase inhibitors developed for
the treatment of liver disease. Bioorg Med Chem Lett., 19: 199-202.
Umadevi, S., V. Gopi, A. Parthasarathy and V. Elangovan. 2011. Ameliorative
potential of gallic acid on the activation of ROS and down-regulation of antioxidant
enzymes in cardiac tissue of rats infused with advanced glycation end products.
Journal of Applied Pharmaceutical Science ., 07: 189-193.
Umiyal, B.P., L.R. Singh, and K.K. Nagpal, 1998. Effects of hypothyroidism and
hyperthyriods on serum glucoproteins in experimental rats.Indian J Exp. Biol.,36: 148
-151.
University of Wisconsin Chemical Safety and Disposal Guide (UWCSDG)
.1999.Chemical and Environmental Safety Program, University of Wisconsin-
Madison 30 N. Murray St., Madison, WI. 53715- 2609.
Ursini,F.,M.Maiorino,R.Brigelius-Flohe, R.Aumann and K. D. Roveri.1995.Methods
Enzymol.,252, 38-53.
Valko M., M. Izakovic , M. Mazur , C.J.Rhodes and J. Telser .2004. Role of oxygen
radicals in DNA damage and cancer incidence.Mol. Cell Biochem., 266: 37-56.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Vasant Lad., D.1997. .Ayurvedic Perspectives on Selected Pathologies.An Anthology
of Essential Readin from Ayurveda Today Second Edition. Albuquerque, New
Mexico.
Veeru, P.,M.P. Kishor and M. Meenakshi.2009 Screening of medicinal plant extracts
for antioxidant activity. J. Med. Plants Res., 3: 608-612.
Venkatesh,P., A. Dinakar, N. Senthilkumar.2013.Screening of hepatoprotective and
antioxidant activity of alcoholic extracts of Boerhaavia difusa and Ansochilus
carnosus. Int., J. Pharm. and Pharmceut. Sci. 2: 208-201.
Venkatraman, P., R.Wetzel, M.Tanaka and N.Nukina.2004.Eukaryotic proteasomes
cannot digest polyglutamine sequences and release them during degradation of
polyglutamine-containing proteins. Mol Cell., 14: 95 104
Vermeulen, N.P.E., J.G.M. Bessems, R. van de straat, 1992. Molecular aspects of
paracitamol-induced hepatotoxicity and its mechanism of prevention.Drug Metabol.
Rev., 24: 367-407.
Vickers A and C. Zollman. 1999. ABC of complementary medicine: herbal medicine.
BMJ.,319: 1050 -1053.
Vuda, M., R. DeSouza, S. Upadhya, V.Kumar and P. Mungli. 2012. Hepatoprotective
and antioxidant activity of aqueous extract of Hybanthus enneaspermus against CCl4-
induced liver injury in rats. Exp Toxicol Pathol., 64:855-9.
Wada, H, M.Usui and N. Sakuragawa.2008. Hemostatic abnormalities and Liver
Diseases. Semin Thromb Hemost., 34: 772-778.
Wallace, J. L.2005.Nitric oxide as a regulator of inflammatory processes, Mem Inst
Oswaldo Cruz, Rio de Janeiro.,100: 5-9.
Walter, K. and C.Schütt.1974. In Methods of Enzymatic Analysis (Bergmeyer, H.U.
ed) 2nd ed., Volume II, pp 860-864, Academic Press, Inc., NY.
Wang ,A. and G. Tiegs, 1986. Protection by ebselen (P251) against D
galactosamine/ endotoxin induced hepatitis in mice. Biochem.Pharmacol., 35: 2115
2118.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Wang, B., W.F. Feng , T.C.Wang , G. Jia , M.Wang and J.W.Shi .2006. Acute
toxicity of nano- and micro-scale zinc powder in healthy adult mice. J
Ethnopharmacol .,161:115-123.
Wang, Y., R.Singh and H. Lefkowitch.2006.Tumor necrosis factor-induced toxic liver
injury results from JNK2-dependent activation of caspase-8 and the mitochondrial
death pathway. J. Biol. Chem., 281: 15258 15267.
Ward, F. M and M. J., Daly 1999.Hepactic disease. In: Clinical pharmacy &
therapeutics (Walker R. & C. Edwards Eds.). Churchill Livingstone, Newyork, PP:
195-202
Watanabe, S and M.J. Phillips. 1986.Acute phalloidin toxicity in living hepatocytes:
evidence for a possible disturbance in membrane flow and for multiple functions for
actin in the liver cell. American Journal of Pathology ., 122: 101-111.
Watkins,P.B and L.B. Seef. 2006. Drug-induced liver injury: summary of a single
topic clinical research conference. Hepatology., 43: 618-631.
Wattiaux, R.,S.Wattiaux-De Coninck.,M F Ronveaux-dupal, and F Dubois.1978.
Isolation of rat liver lysosomes by isopycnic centrifugation in a metrizamide gradient.
The journal of cell biology.78: 349-368.
Weerasak Samee, R and S.Suwanna Vorarat.2007. Simultaneous determination of
Gallic acid, Catechin, Rutin,Ellagic Acid and Quercetin in Flower Extracts of
Michelia alba,Caesalpinia pulcherrima and Nelumbo nucifera by HPLC. Thai
Pharm Health Sci J .,2:131-137.
Weniger, B.,L. Lagnika ,C. Vonthron-Senecheau , T.Adjobimey and J.Gbenou .2004.
Evaluation of ethno botanically selected medician plant Hybanthus enneaspermus. J
Ethnopharmacol., 90: 279-284.
West, E.S., W.R. Todd, H.S. Manson, and J.T. van Bruggen, 1992.Protein
metabolism. In: West Es and Todd Er(eds). Text Book of Biochemistry, 4th edition,
Oxford IBH publishing company, Private Ltd. New Delhi. 1143-1263.
WHO 2002.Quality Control Methods for Medicinal Plant Materials. (An authorized
publication of World Health Organisation, Geneva).A.I.T.B.S. Publishers &
Distributors, New Delhi.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Wichi, H. P. 1988. Enchanced tumpr development by butylated hydroxyanisole
(BHA) from the perspective of effect on forestomach and oesophageal squamous
epithelium. Food and Chemical Toxicology., 26:717 723.
pp73-78.
Willner, I.R., M.D. Uhl, S.C Howard, E.Q. Williams and B.Waters.1998. Serious
hepatitis A: an analysis of patients hospitalized during an epidemic in the United
States. Ann Intern Med., 128: 111-114.
Wilson, K.J.W and A. Waugh. 1996, Anatomy and Physiology in Health and illness,
Churchill Livingstone, New York, Edinburgh, London.8: 306-310.
Wink, M., A.W.Alfermann ,R. Franke ,B. Wetterauer and P.Ripplinger. 2005.
Sustainable bioproduction of phytochemicals by plant in vitro cultures; anticancer
agents. Plant Genetic Resour., 3: 90-100.
Witherup, K..M.,S.A. Look, M.W. Stasko, T.J. Ghiorzi, G.M. Muschik.1990. Taxus
spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia:
analysis and isolation. Journal of Natural Products., 53: 1249-1255.
Wolf, P.L. 1999. Biochemical diagnosis of liver diseases. Ind J Clin Biochem. ,
14:59 90.
Wong, C., H.Li ,K. Cheng and C. Feng C. 2006.A systematic survey of antioxidant
activity of 30 Chinese medicinal plants using the ferric reducing antioxidant power
assay. Food Chem., 97:705-711.
Worman, H.J.1997.Molecular biological methods in diagnosis and treatment of liver
diseases.Clinical Chemistry., 43: 1476-1486.
Wu, Y.H., Y.Z. Cai and Y. Zhang . 2009. Natural Phenolic Compounds from
Medicinal Herbs and Dietary Plants: Potential Use for Cancer Prevention. Nutr.
Cancer., 62: 1-20.
Wybenga, D.R., V.J.Pileggi, P.H. Dirstine and J. Di Giorgio. 1970. Direct manual
determination of serum total cholesterol with a single stable reagent. Clin. Chem., 16 :
980-984.
Print to PDF without this message by purchasing novaPDF (http://www.novapdf.com/)
Yamaguchi,M.,Y. Nishida,T. Moriuchi and F. Hirose.1994. Drosophila PCNA/cyclin
gene: Structure and expression during development and specific binding of homeodomain proteins to its flanking region. Mol Cell Biol .,10:872 879.
Yamamuro,Y.2006.Social behavior in laboratory rats: Applications for psychoneuroethology studies. Animal Science Journal., 77 : 386 94.
Yang ,K., N.Kurihara, K. Fan , H. Newmark and B. Rigas. 2008. Dietary induction of colonic tumors in a mouse model of sporadic colon cancer. Cancer Res., 68 : 7803
10.
Yasuda, M., T. Okabe,J.Itoh ,S.Takekoshi S,H.Hasegawa and K. Watanabe.2000 Differentiation of necrotic cell death with or without lysosomal activation: Application of acute liver injury models by carbon tetrachloride (CCl4) and dimethylnitrosamine (DMN). J. Histochem.Cytochem., 48: 1331-1340.
Yeagle, P.L., 1983. Chloestrol modulation of Na+/K+ ATPase, ATP hydroxyl activity in the human erythrocyte.Biochem.Biophys.Alta. ,727:39-44.
Yoganarasimhan, S.N.2000. In: Medicinal Plants of India-Tamilnadu, Vol II, Cyber Media, Bangalore, 276.
Yu, L., F.N.Yang,J.W. Liu and D.X. Chen.2007. Effects of Rosa roxburghii extract on proliferation and differentiation in human hepatoma .SMMC 7721 cells and CD34+ haematopoietic cells.J. Health Sci., 53: 10-15.
Zhao,Y., X. Yin, H. Qin, F. Zhu, H. Liu and W. Yang. 2008. Two supporting factors greatly improve the e Cell Stem Cell ., 3: 475479.
Zilversmit, D.B and A.Davis.1972 .Micro-determination of plasma phospholipids by trichloroacetic acid precipitation.Journal of Laboratory clinical medicine., 35: 155-60. Zimmerman, H.J. 1999. Drug-induced liver disease. In: Zimmerman HJ, ed. Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver. 2nd ed. Philadelphia, PA: Lippincott Williams and Wilkins 4th ed.427- 456.
Zlatkis, A., B.Zak and A.J.Boyle. 1953: A new method for the direct determination of serum cholesterol. J. Lab Clin. Med., 41: 486-492.
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