DefinitionDefinition
Circulatory system failure to supplyCirculatory system failure to supplyoxygen and nutrientsoxygen and nutrients to meet cellular to meet cellular
metabolic demandsmetabolic demands. .
ShockShock Classification and causesClassification and causes::
HypovolemicHypovolemicDistributiveDistributiveCardiogenicCardiogenicObstructiveObstructivedissociativedissociative
HemodynamicsHemodynamics
MyocardialContractility
Stroke Volume Preload
Cardiac Output Afterload
Blood Pressure Heart Rate
Systemic Vascular Resistance
Textbook of Pediatric Advanced Life Support, 1988Textbook of Pediatric Advanced Life Support, 1988
Cardiovascular functionCardiovascular function
Cardiac OutputCardiac OutputCO = HR x SVCO = HR x SVHR responds the quickestHR responds the quickest
SV is a function of three variablesSV is a function of three variables: : preloadpreload , ,After loadAfter load , ,
myocardial contractilitymyocardial contractilityA noncompliant heart cannot increase SVA noncompliant heart cannot increase SV
Cardiovascular functionCardiovascular function
11--Cardiac OutputCardiac Output22--Clinical AssessmentClinical Assessment
peripheral perfusionperipheral perfusionTemperatureTemperaturecapillary refillcapillary refillurine outputurine outputMentationMentationacid-base statusacid-base status
Hypovolemic shockHypovolemic shock Definition:Definition: Decreased circulating blood volume.Decreased circulating blood volume.
Common causes:Common causes: HemorrhageHemorrhage DiarrheaDiarrhea Diabetes insipidusDiabetes insipidus Diabetes mellitusDiabetes mellitus BurnsBurns Adrenogenital syndromeAdrenogenital syndrome
Distributive shockDistributive shock DefinitionDefinition
Vasodilation and decreased preloadVasodilation and decreased preload
Common causesCommon causes::SepsisSepsisAnaphylaxisAnaphylaxisSpinal injurySpinal injuryDrug intoxicationDrug intoxication
Cardiogenic shockCardiogenic shock Decreased myocardial contractilityDecreased myocardial contractility
Common causes:Common causes: Congenital heart diseaseCongenital heart disease Severe heart failureSevere heart failure ArrhythmiaArrhythmia hypoxic ischemic injurieshypoxic ischemic injuries CardiomyopathyCardiomyopathy MyocarditisMyocarditis Drug intoxicationDrug intoxication kawasakikawasaki
Obstructive shockObstructive shockDefinitionDefinitionMechanicalMechanical obstruction to ventricular obstruction to ventricular
outflow.outflow.Common causes:Common causes: Cardaic tamponadeCardaic tamponade Massive pulmonary embolusMassive pulmonary embolus Tension pneumothoraxTension pneumothorax Cardiac tumorCardiac tumor
Dissociative shockDissociative shockDefinitionDefinition Oxygen not released from hemoglobin.Oxygen not released from hemoglobin.
Common causesCommon causes1.1. Carbon monoxide poisoningCarbon monoxide poisoning2.2. methemoglobinemiamethemoglobinemia
Organ directed Organ directed therapeuticstherapeutics
Cardiovascular supportCardiovascular support Fluid resuscitationFluid resuscitation Cardiotonic and vasodilatorCardiotonic and vasodilator therapy therapy RespiratoryRespiratory support support RenalRenal salvage salvage
Cardiovascular Changes in Cardiovascular Changes in ShockShock
Type Preload Type Preload Afterload Afterload ContractilityContractility
Cardiogenic
Hypovolemic No change
Distributive
Septicearly
late
EvaluationEvaluation Regardless of the cause: ABCRegardless of the cause: ABC
First assess airway patencyFirst assess airway patency ventilationventilation
then circulatory systemthen circulatory system
EvaluationEvaluation Respiratory PerformanceRespiratory Performance
Respiratory rate and patternRespiratory rate and pattern work of breathing work of breathing oxygenation (color)oxygenation (color) level of alertnesslevel of alertness
CirculationCirculation Heart rate, BP, perfusion, and pulses, liver Heart rate, BP, perfusion, and pulses, liver
sizesize CVP monitoring may be helpfulCVP monitoring may be helpful
EvaluationEvaluation Early Signs of ShockEarly Signs of Shock
sinus tachycardia.sinus tachycardia.
delayed capillary refill.delayed capillary refill.
fussy, irritable.fussy, irritable.
Late Signs of ShockLate Signs of Shock
EvaluationEvaluation Late Signs of ShockLate Signs of Shock
bradycardiabradycardia altered mental status (lethargy, coma)altered mental status (lethargy, coma) hypotonia, decreased DTR’shypotonia, decreased DTR’s Cheyne-Stokes breathingCheyne-Stokes breathing hypotension is a very late signhypotension is a very late sign
Cardiovascular Assessment Cardiovascular Assessment (con)(con)
CNS Perfusion
Recognition of parents Reaction to pain Muscle tone Pupil size
Renal Perfusion UOP >1cc/kg/hr
Cardiovascular Assessment Cardiovascular Assessment (con)(con)
Skin Perfusion
Capillary refill time Temperature Color Mottling
Therapy for shockTherapy for shock The key therapy is the recognition of The key therapy is the recognition of
shock in its early state.shock in its early state. Treating the signs and symptoms.Treating the signs and symptoms. Minimize cadiopulmonary work.Minimize cadiopulmonary work. Ensuring cardiac output blood pressure Ensuring cardiac output blood pressure
and gas exchangeand gas exchange
Hypovolemic ShockHypovolemic Shock Mainstay of therapy is fluidMainstay of therapy is fluid . .
Goals:Goals:
1.1. Restore intravascular volumeRestore intravascular volume2.2. Correct metabolic acidosisCorrect metabolic acidosis3.3. Treat the causeTreat the cause
Hypovolemic Shock Hypovolemic Shock (treatment)(treatment)
Degree of dehydration often underestimatedDegree of dehydration often underestimated Reassess perfusion, urine output, vital signs...Reassess perfusion, urine output, vital signs...
Isotonic crystalloid is always a good choiceIsotonic crystalloid is always a good choice 20 to 50 cc/kg rapidly if cardiac function is 20 to 50 cc/kg rapidly if cardiac function is
normalnormal NS can cause a hyperchloremic acidosisNS can cause a hyperchloremic acidosis
Other StudiesOther Studies
Look for etiology of shock.Look for etiology of shock.
Evaluate hemoglobin, hematocrit, and platelet count.Evaluate hemoglobin, hematocrit, and platelet count.
Shock from any etiology can lead to DIC and end organ Shock from any etiology can lead to DIC and end organ damagedamage
Other StudiesOther Studies CBC, PT, INR, PTT, Fibrinogen, Factor V, CBC, PT, INR, PTT, Fibrinogen, Factor V,
Factor VIIIFactor VIII
Check LFT’s, follow CNS and pulmonary Check LFT’s, follow CNS and pulmonary statusstatus
ConclusionConclusion
Goal of therapy is;Goal of therapy is; identificationidentification evaluationevaluation and treatment of shock in its earliest stageand treatment of shock in its earliest stage
Successful resuscitation depends on early and judicious Successful resuscitation depends on early and judicious interventionintervention
Initial priorities are for the ABC’sInitial priorities are for the ABC’s
ConclusionConclusion Fluid resuscitation begins with 20cc/kg of Fluid resuscitation begins with 20cc/kg of
crystalloid or 10cc/kg of colloidcrystalloid or 10cc/kg of colloid
Subsequent treatment depends on the Subsequent treatment depends on the etiology of shock and the patient’s etiology of shock and the patient’s homodynamic conditionhomodynamic condition
Related infection and shockRelated infection and shock InfectionInfection BacteremiaBacteremia Systemic inflammatory response syndrome : Systemic inflammatory response syndrome : (2 or>2 of following)(2 or>2 of following)(T>38(T>38 HR>90HR>90RR>20RR>20WBC>12000 or<4000)WBC>12000 or<4000)
Related infection and shockRelated infection and shock Sepsis:Sepsis: Systemic response to infectionSystemic response to infection
Sever sepsis:Sever sepsis: sepsis + organ dysfunctionsepsis + organ dysfunction(hypo perfusion, lactic acidosis, oliguria,or an (hypo perfusion, lactic acidosis, oliguria,or an
acute alter mental status)acute alter mental status)
Related infection and shockRelated infection and shock Septic shock:Septic shock: sepsis +hypotention despid adequate fluidsepsis +hypotention despid adequate fluid
Hypotention:Hypotention: systolic<9 or >4reductionsystolic<9 or >4reduction Multiple organ dysfuntionMultiple organ dysfuntion
BurnsBurns Disruption 3 key function of skinDisruption 3 key function of skin
1.1. Regulation of heat lossRegulation of heat loss2.2. presevation of body fluidpresevation of body fluid3.3. Barrier of the infectionBarrier of the infection
PatophisiologyPatophisiology Release inflammatory and vasoactive Release inflammatory and vasoactive
mediatorsmediators capillary permeability increasecapillary permeability increase Decrease plasma volume and cardiac Decrease plasma volume and cardiac
outputoutput Shock is common if borne > 10% -12%Shock is common if borne > 10% -12%
classificationclassification1.1. Depth of injuryDepth of injury2.2. Percent of body surface area involvedPercent of body surface area involved3.3. Location of the burnLocation of the burn4.4. Association with other injuriesAssociation with other injuries
Clinical manifestationClinical manifestation1-First – degree:1-First – degree: Red, painful dray Red, painful dray Superficial and limited to epidermis.Superficial and limited to epidermis. Heal in 3-6 daysHeal in 3-6 days
Clinical manifestationClinical manifestation2-Second degree:2-Second degree: Partial-thicking Partial-thicking 1-1-superficialsuperficial ( ( red,painful,red,painful,blisterblister) heal in ) heal in 10-10-
2121 days days2-deep dermal2-deep dermal( ( pale ,painful, yellowpale ,painful, yellow)) heal in 3 heal in 3
weeks , scarringweeks , scarring
Clinical manifestationClinical manifestation3-Third –degree:3-Third –degree: Full thickness ,require grafts if >1 cmFull thickness ,require grafts if >1 cm Avascular and coagulation necrosisAvascular and coagulation necrosis
4- fourth – degree:4- fourth – degree: Involve underling facia, muscle or boneInvolve underling facia, muscle or bone
Clinical manifestationClinical manifestation Sever burn:Sever burn: >15%Body surface>15%Body surface involves face or prineum involves face or prineum 2 and 3 –degree burns hands or feet 2 and 3 –degree burns hands or feet
circumfrential burn of extermity circumfrential burn of extermity inhalation injuryinhalation injury
Percent of body surface area Percent of body surface area involvedinvolved
Each upper extremity 9%Each upper extremity 9% each lower extremity 18% each lower extremity 18% Posterior trunk 18%Posterior trunk 18% Anterior trunh 18%Anterior trunh 18% Head 9% and prinium1%Head 9% and prinium1%Location is important :Location is important : Face, eyes, ears, feet, prinium, hand ,full Face, eyes, ears, feet, prinium, hand ,full
thicknessthickness
treatmenttreatment decision is based on :decision is based on : Extent of burnExtent of burn(% burn)(% burn) , body surface , body surface (location),(location),
type type of burn, of burn, associated injureassociated injure, , medical complication ,availability medical complication ,availability ambulatory managementambulatory management
Stop the burning processStop the burning process Fluid and electrolyte support Fluid and electrolyte support
((systemic copillary leaksystemic copillary leak))
treatmenttreatment
Significant burn , Second 24 hr dextrose Significant burn , Second 24 hr dextrose in0.25 normal in0.25 normal bolus 20cc/kg lactated Ringerbolus 20cc/kg lactated Ringer
Total fluid is 2-4cc/kg/percent burn/24 hrTotal fluid is 2-4cc/kg/percent burn/24 hr ((Half in first 8 hrHalf in first 8 hr) that equal 1cc/kg/hr of urine) that equal 1cc/kg/hr of urinesalinesaline Colloid therapy is needed if burn >30% bs Colloid therapy is needed if burn >30% bs
and provided after 24 hr with crystalloidand provided after 24 hr with crystalloid
treatmenttreatment Nutritional support:Nutritional support: ( burn produce hypermetabolic response ( burn produce hypermetabolic response
that sedation and analgesic can decrease)that sedation and analgesic can decrease)
In critical burn parenteral nutrition In critical burn parenteral nutrition Enteral feeding résumé on 2-3 daysEnteral feeding résumé on 2-3 days
treatmenttreatment Wound care:Wound care: Relief any pressure on cerculationRelief any pressure on cerculation Covered with sulfadiazin Covered with sulfadiazin GraftGraft Tetanus toxoid in incomplete Tetanus toxoid in incomplete
immunization immunization
hospitalizationhospitalization Extended of burn Extended of burn > 10% in children in children
Body surface area involved:Body surface area involved:Face ,neck, both hands, both feet ,prineumFace ,neck, both hands, both feet ,prineum
Type of burn; Type of burn; electrical contact ,chemicalelectrical contact ,chemical Association injuries;Association injuries;Soft tissue trauma, fractures,smoke inhalation Soft tissue trauma, fractures,smoke inhalation
head injury .head injury .
hospitalizationhospitalization Complicating medical problemsComplicating medical problems Diabetes ,heart disease, pulmonary disease, ulcer Diabetes ,heart disease, pulmonary disease, ulcer
history.history. Social problemSocial problem..Suspected child abuse or neglect, self infected Suspected child abuse or neglect, self infected
burn, psycologic problemsburn, psycologic problems
Burn ComplicationBurn Complication Sepsis ( avoid prophylactic antibiotic)Sepsis ( avoid prophylactic antibiotic) Hypovolemia, hypothermia Hypovolemia, hypothermia laryngeal edemalaryngeal edema carbon monoxide injurycarbon monoxide injury(100% o2,hyper baric o2)(100% o2,hyper baric o2) cardic disfunctioncardic disfunction gasteric ulcergasteric ulcer
Burn ComplicationBurn Complication compartment syndromecompartment syndrome contracturecontracture hyper metabolic statehyper metabolic state renal failurerenal failure anemiaanemia psychological traumapsychological trauma pulmonary infiltration,pulmonary pulmonary infiltration,pulmonary
edema, pneumonia,bronchospasmedema, pneumonia,bronchospasm