Annual Report of the

Department of

Molecular & Integrative

Physiology

University of Kansas Medical Center

July 1, 2014-June 30, 2015

TABLE OF CONTENTS Year in Review ………………………………………………………1 Department Roster ………………………………………………………9 Graduate Student Notes ………………………………………………15 Courses Taught ……………………………………………………....19 Department Seminars ………………………………………………21 Publications

a. Published (7/1/14-6/30/15) ………………………………27

b. In Press ………………………………………………………35 c. Abstracts ……………………………………………………… 37

Research Support ……………………………………………………… 43 Staff Activities ……………………………………………………… 51

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YEAR IN REVIEW 2014-2015

Department leadership changes

On July 1st of 2014, Dr. Peter Smith was named Interim Chair of the Department of Molecular and Integrative Physiology, following Dr. Paul Cheney. Six month later, Dr. Smith started as Senior Associate Dean for Research of our Institution and he stepped down as head of our Department. Dr. Gustavo Blanco took over the position of Interim Chair of Physiology, starting February 1st, 2015. During Dr. Smith’s relative short tenure as Interim Chair, he continued working hard towards keeping the Department of Physiology strong. He supported all current research programs and importantly, he was able to recruit a new Faculty member, Dr. John Thyfault to the Department. This was an impressive accomplishment considering the current shortage of funds. Recruitment of Dr. Thyfault represents an important enhancement for our Department. He has brought with him new expertise, research projects and technologies that will help advance the research efforts and the overall mission of our Department.

Subsequently, under Dr. Blanco, the Department has continued to hold up well, despite the continuing difficult funding environment at the Federal and State levels. The state of Kansas faced serious budget challenges and KU Medical Center sustained a $2.1 million reduction in allotments or budget cuts for fiscal year 2015. Research programs in the various areas have continued vibrant and the Department has maintained a consistent publication level and funding. Also, the Department has had another important year with respect to teaching. In the medical curriculum, the Department was responsible for the Cardiopulmonary and Renal-Endocrine modules. Two of our Faculty, Dr. John Wood and Dr. Michael Wolfe have played an instrumental role in leading those modules. In addition, several of our faculty have been recognized with important teaching awards for their efforts in medical education. Our Faculty have also continued making important contributions to the core IGPBS curriculum and they run different Advanced Physiology courses. We can proudly attest that Physiology Faculty are committed to high quality teaching and are significantly involved in the education mission of our Institution. Regarding service, Dr. Blanco restructured several committees. Our Faculty have served in numerous key committees at our University, the national and international level. Numerous members of our faculty served on NIH grant review panels, editorial boards for different journals and made presentations as invited speakers at other Universities, and national and international meetings. Without a doubt, the continued success of our Department during the period 2014-2015, and over the years, can be credited to the talent and hard work of our Faculty.

Another outstanding aspect to highlight is the excellent support from the office staff. A special thank you to our Senior Administrator, Shari Standiferd for her dedication and hard work. Soon after Dr. Blanco started as Interim Chair, he decided to move the office from its location in the 2nd floor of the Hemenway building to the ground floor of Wahl Hall East. This has helped enhance the identity of our Department and placed the office in a location similarly distant from all Physiology laboratories. Also, changes were made regarding the office staff, with the hire of two part time administrators. This has improved service coverage for all members of the Department.

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Finally, we would like to recognize our great supporter and advocate, Jim Osborn, his wife Marion, and his daughter Kathleen. The very generous contributions that they have made over the years have importantly contributed to our success. The lectureship in honor of Kathleen M. Osborn continued this year and is the longest named lectureship at KUMC. We have also enjoyed two endowed professorships that have supported by Mr. Osborn. The Marion M. Osborn Professorship, held by Dr. Leslie Heckert, and the Kathleen M. Osborn Chair, which was formerly held by Dr. Paul Cheney. In addition, Mr. Osborn’s funds have supported a student fellowship in the honor of Kathleen Osborn. After a competitive application process, the first fellowship was presented in the fall of 2014 and the recipient was Faezeh Koohestani, Ph.D., who received it in the fall of 2014. Once again, all members of our Department immensely appreciate the continuous support of Jim Osborn and his family.

HIGHLIGHTS FROM THE 2014-2015 ACADEMIC YEAR

RESEARCH FUNDING: Based on data provided by KUMC Enterprise Analytics, total research funding for the Department was almost 8 million dollars ($7,885,987), an amount which was similar to that of the previous year. Total NIH funding was $4,223,748, which is lower than that of last year ($4,908,943). The latest data available shows that our Department was ranked 31st at the national level for NIH research funding among 82 medical schools receiving NIH funding. While this is a good position for our Department, we would like to improve this ranking. Most of our research programs are supported by major external funding. This is something that we are proud of, especially taking into consideration the extremely

James & Marion Osborn Kathleen Osborn

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difficult current funding environment. We owe this to the dedication of our Faculty, who have continued crafting high quality research grant proposals.

EDUCATION: The Department has had another outstanding year with respect to teaching. As mentioned previously, Dr. John Wood and Dr. Michael Wolfe lead two key modules of the medical curriculum, the Cardiopulmonary and Renal-Endocrine modules. The Cardiopulmonary module received from the medical students an award for being the best module, presented to the Department at the “Grande Affair” celebration in April. At this same event, two of our Faculty members, Dr. John Wood and Dr. Gustavo Blanco were recognized with ”Student Voice Awards” for their excellence in teaching. These awards are a testimony of the long lasting commitment of our Faculty members to education.

TENURE TRACK APPOINTMENTS: Dr. John Thyfault was recruited in the Department as Associate Professor on April 1st, 2015. He came to us from the Department of Nutrition & Exercise Physiology in University of Missouri, Columbia. Dr. Thyfault is working in the area of exercise and how this modifies liver and muscle metabolism.

RESEARCH TRACK APPOINTMENTS: No new research track appointments were made this year. JOINT AND ADJUNCT APPOINTMENTS: Dr. Randolph Nudo, who transferred to Rehabilitation Medicine as new Vice Chair of Research, was approved for a joint appointment as Professor in our department beginning October 1, 2014. FACULTY PROMOTIONS: Dr. Vargheese Chennathukuzhi was promoted to Associate Professor with tenure starting July 1, 2015. We are delighted for Dr. Chennathukuzhi’s accomplishments. During the years after being recruited, he has developed a well-funded research program in the area of uterine leiomyomas and he has built a strong research group. Dr. Shahid Umar was granted tenure at the Associate Professor level. He has developed a strong research program in the area of colon inflammation and cancer. We are proud of these Faculty members. FACULTY/STAFF DEPARTURES: There have been some departures from the Department. Dr. Vijayalaxmi Gupta, left on February 1, 2015 to work in the Department Hematology and Oncology here at KUMC. Her current research focus is now multiple myeloma, breast cancer and pancreatic cancer. Dr. Ramakrishna Hegde, Ph.D. left on February 16, 2015 to work as Chief Scientific Officer in MicroProtein Technologies Inc., a biotechnology company in Lenexa, Kansas. There he works on development of reagents for diagnostic and therapeutic use. Dr. Lynda McGinnis, left on May 13, 2015 to work as Assistant Professor and Director of the Molecular Reproduction Research Laboratory, in the Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility in University of Southern California Keck School of Medicine, Los Angeles, CA. Her current project is directed to study the effects of tyrosine kinase inhibitors on reproduction for cancer survivors. In addition, she maintains a collaboration with Dr. Lane Christenson in our Department, to study exosome/microvesicle regulation of oocytes developmental competence, funded through an NIH multi-PI R21 from NICHD.

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After 39 years and 8 months of service to the University of Kansas Medical Center and a long and distinguished career, Dr. Paul Terranova officially retired from his position as Professor and Vice Chancellor of Research. Dr. Terranova now is an Emeritus Professor in Physiology. We wish him the best in his retirement. FACULTY AWARDS/ACCOMPLISHMENTS: Dr. Shrikant Anant won the 2014 Research Investigator Award, which was presented to him at Faculty Research Day on October 27, 2014. These awards are given to investigators, who have demonstrated outstanding accomplishments in research and a high potential for development of new research avenues in the future. This award carries a $1,000 stipend. Dr. Paige Geiger won the 2014 Glendon G. Cox Leadership Award. This award was presented at the annual School of Medicine Faculty Retreat. This award carries a $2,500 stipend. Congratulations to these researchers. GRADUATE PROGRAM AND PHYSIOLOGY SOCIETY: The student led Physiology Society continued functioning this year. A new committee started, integrated by: Mina Farahbakhsh (President) Wei-Ting Hung (Vice-President) Kelsey Hampton (Social Chair) Asona Lui (Interim Stower’s Chair) The graduate students in the department had another active year. We are very pleased with the growth of the graduate program in Physiology. In 2014-2015 eight new students were recruited to the department. These include students who are working at Stowers Research Institute, with faculty members who have academic appointment in Physiology. Currently, our Department has a total of 30 enrolled doctoral students. Several of our students were able to obtain external fellowships to support their training. Funding came from different sources, including the SELF Fellowship program, the KUMC Biomedical Training Program, NSF, and NIH.

The new graduate students included the following individuals and their respective mentors are listed in parenthesis: Summer 2014 Joshua Curry (Dr. Alan Yu) Blake Ebner (Dr. Kausik Si) Mina Farahbakhsh (Dr. Vargheese Chennathukuzhi) Eric Young (Dr. Danny Welch) Fall 2014 Erin Hayes (Dr. Joan Lewis-Wambi) Akshay Narkar (Dr. Rong Li) Zelha Nil (Dr. Kausik Si) Ashley Ward (Dr. Paige Geiger) Three students completed their PhD degrees and 2 students completed a Master’s degree during the year. Congratulations to all of them and their mentors. These are listed below:

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Summer 2014 Fall 2014 Spring 2015

Naveen Neradugomma – PhD Kayla Raider – MS Erin Hayes – MS Guangbo Chen – PhD Lili Pan – PhD Naveen Neradugomma (May 14, 2014) received his degree with Dr. Anant. The title of his dissertation was “Role of Prolactin and Prolactin Receptor Signaling in Colorectal Tumorigenesis”. Naveen is a Senior Research Fellow Department of Pharmaceutics,

University of Washington.

Kayla Raider (September 14, 2014) received her MS degree with Dr. Stanford. The title of her thesis was “Effects of a high fat diet on brain metabolism in rats: An in vivo 1H-MRS study”. Kayla Raider is now a stay at home mother with two children. Erin Hayes received her degree with Dr. Lewis-Wambi on (April 27, 2015). The title of her thesis was “microRNA Sequencing of Long-Term Estrogen Deprived Breast Cancer Cells Reveals a Potential Role for miR-181a in Estrogen-Independent Growth”. Erin Hayes is now working as an instructor for Blue Valley Center for Advancing Professional Studies. Guangbo Chen (January 15, 2015) received his degree with Dr. Li. The title of his dissertation was “Target the adaptability of heterogenous aneuploidy populations”. Guangbo is currently working at Stanford University. Lili Pan (January 15, 2015) received her degree with Dr. Peter Baumann from Stowers. The title of her dissertation was “Telomere architecture and maintenance in Schizosaccharomyces pmbe”. Lili is Postgraduate Researcher at Stowers Institute for

Medical Research in Peter Baumann's laboratory.

Prepared by:

V. Gustavo Blanco, MD/PhD Professor and Interim Chair

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Department of Molecular & Integrative Physiology Faculty

2014-2015 Front Row (left to right): Paul Cheney, Paige Geiger, John Stanford, Phil Lee, Gustavo Blanco, Michael Wolfe, Peter Smith Back Row (left to right): Vargheese Chennathukuzhi, Steven LeVine, Lane Christenson, John Thyfault, Norberto Gonzalez, Shahid Umar, Melissa Larson, Dharmalingam Subramaniam, Leslie Heckert, Andrei Belousov, Warren Nothnick, John Wood Not Pictured: David Albertini, Shrikant Anant, Sam Enna, Sumedha Gunewardena, T. Rajendra Kumar, Prabhu Ramamoorthy, Joseph Tash

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Department of Molecular & Integrative Physiology Graduate Students 2014-2015

Right Row (top to bottom): Wei-Ting Hung, Kelsey Hampton, Mina Farahbakhsh, Lei Pei Left Row (top to bottom): Joshua Curry, Amanda Brinker, Jessica Venugopal Not Pictured: Amy Cantilena, Guangbo Chen, Li Chen, Blake Ebner, Erin Hayes, Swathi Iyer, Mohammed Khan, Liying Li, Asona Lui, John Mcginnis, Michelle McWilliams, Danny Miller, Wahid Mulla, Akshay Narkar, Zelha Nil, Lili Pan, Margaret Pruitt, Archana Raman, Robert Rogers, Nairita Roy, Ashley Ward, Eric Young, Chuankai Zhou

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DEPARTMENT ROSTER July 1, 2014 – June 30, 2015

a. Faculty

Primary Appointment in Physiology V. Gustavo Blanco, M.D., Ph.D., Professor & Interim Chair David F. Albertini, Ph.D., Professor Shrikant Anant, Ph.D., Professor; Tom and Teresa Walsh Professor of Cancer Prevention; Eminent Scholar, Kansas Bioscence Authority; Associate Director for Prevention and Cancer Control Andrei Belousov, Ph.D., Associate Professor Paul D. Cheney, Ph.D., Professor Vargheese M. Chennathukuzhi, Ph.D., Assistant Professor Lane K. Christenson, Ph.D., Associate Professor Salvatore J. Enna, Ph.D., Professor; Associate Dean for Research and Graduate Education Paige C. Geiger, Ph.D., Associate Professor Norberto C. Gonzalez, M.D., Professor Leslie L. Heckert, Ph.D., Marion M. Osborn Professor for Reproductive Sciences T. Rajendra Kumar, Ph.D., Professor, Director of the Center for Reproductive Sciences Phil Lee, Ph.D., Associate Professor Steven M. LeVine, Ph.D., Professor Warren Nothnick, Ph.D., Professor Randolph J. Nudo, Ph.D., Professor, Director of The Landon Center on Aging,

Vice Chair- of Research Peter G. Smith, Ph.D., Professor, Director of the Institute for Neurological

Disorders, Co-Director of the Kansas Intellectual and Developmental Disabilities Research Center, Senior Associate Dean for Research

John A. Stanford, Ph.D., Associate Professor Joseph S. Tash, Ph.D., Professor

John P. Thyfault, Ph.D., FACSM, Associate Professor Shahid Umar, Ph.D., Associate Professor Michael W. Wolfe, Ph.D., Associate Professor John G. Wood, Ph.D., Associate Professor Emeritus Lawrence P. Sullivan, Ph.D., Professor Thomas J. Imig, Ph.D., Professor Paul F. Terranova, Ph.D., Professor James L. Voogt, Ph.D., Professor

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Stowers Affiliates Peter Baumann, Ph.D., Professor Scott Hawley, Ph.D., Professor Sue Jaspersen, Ph.D., Associate Professor Rong Li, Ph.D., Professor Kausik Si, Ph.D., Associate Professor Research Track Faculty Shawn Frost, Ph.D., Research Assistant Professor Sumedha Gunewardena, D.Phil., Research Assistant Professor Vijayalaxmi Gupta, Ph.D., Research Assistant Professor Ramakrishna Hegde, Ph.D., Research Assistant Professor Melissa Larson, Ph.D., Research Assistant Professor & Director of

Transgenic Facility Lynda McGinnis, Ph.D., Research Assistant Professor Satish Ramalingam, Ph.D., Research Assistant Professor Prabhu Ramamoorthy, Ph.D., Research Assistant Professor Dharmalingam Subramaniam, Ph.D., Research Assistant Professor

Joint Appointment in Physiology

Richard Barohn, M.D., Professor (Chair, Neurology) Sandra Billinger, PT, Ph.D., FAHA, Associate Professor (Physical

Therapy and Rehabilitation Science) William Brooks, Ph.D., Professor (Director, Hoglund Brain Imaging Center) Jeffrey Burns, M.D., Professor (Neurology, Director of Alzheimer and

Memory Center & Alzheimer’s Disease Clinical Research Program) Mark Chertoff, Ph.D., Associate Professor (Hearing & Speech)

In-Young Choi, Ph.D., Associate Professor (Neurology & Hoglund Brain Imaging Center)

Buddhadeb Dawn, M.D., Professor, Director, Division of Cardiovascular Disease (Internal Medicine)

Animesh Dhar, Ph.D., Research Associate Professor (Cancer Biology) Navneet Dhillon, PhD., Assistant Professor (Pulmonary and Critical Care

Medicine) Dan Dixon, Ph.D., Associate Professor (Cancer Biology) Tomoo Iwakuma, M.D., Ph.D., Associate Professor (Cancer Biology) Jill Jacobson, M.D., Professor (Pediatrics)

Benyi Li, Ph.D., Associate Professor (Urology) Joan Lewis-Wambi,Ph.D., Assistant Professor (Cancer Biology) Joshua Mammen, M.D., Associate Professor (General Surgery) Ajay Nangia, M.B.B.S., FACS, Associate Professor (Urology Surgery) Jules Nazzaro, M.D., Associate Professor (Neurosurgery) Brian Petroff, DVM, Ph.D., Associate Professor (Internal Medicine & Scientific

Director, Breast Cancer Prevention Center) Janet Pierce, D.S.N., ARNP, CCRN, Professor (School of Nursing) Jeff Radel, Ph.D., Associate Professor (Occupational Therapy)

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Joint Appointment in Physiology (continued) Cary Savage, Ph.D., Professor (Psychiatry and Behavioral Science) William (Zhiming) Suo, M.D., Research Associate Professor (Neurology) Russell H. Swerdlow, M.D., Professor (Neurology) Dennis Valenzeno, Ph.D., Associate Dean for Medical Sciences (School of Medicine – Wichita) Darren Wallace, Ph.D., Associate Professor (Internal Medicine) Steven Warren, Ph.D., Professor (Applied Behavioral Science, KU-Lawrence;

Director, Schiefelbucsh Institute for Life Span Studies) Carl Weiner, M.D., M.B.A., Professor (Chair, Ob-Gyn) Danny Welch, Ph.D., Professor & Chairman (Cancer Biology) Alan Yu, MB, B.Chir., Professor & Director (Kidney Institute)

Adjunct Appointment in Physiology

Mark Weiss, Ph.D., Professor (Kansas State University College of Veterinary Medicine)

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b. Graduate Students Amanda Brinker Amy Cantilena Guangbo Chen Li Chen Joshua Curry Blake Ebner Mina Farahbakhsh Kelsey Hampton Erin Hayes Wei-Ting Hung Swathi Iyer Mohammed Khan Liying Li Asona Lui John McGinnis Michelle McWilliams Danny Miller Wahid Mulla Akshay Narkar Zelha Nil Lili Pan Lei Pei Margaret Pruitt Archana Raman Robert Rogers Nairita Roy Jessica Venugopal Ashley Ward Eric Young Chuankai Zhou

Joined Physiology

08/13 06/12 08/08 06/11 06/14 06/14

06/14 08/13 08/14 08/11 08/11 06/11 06/11 06/13 06/12 08/13 08/12 08/12 08/14 08/14 08/10 08/11 04/13 08/12 08/11 08/12 06/11 08/14 06/14 05/10

Prelims 04/14 04/13 01/11 04/12 04/14 04/13 09/12 04/12 04/12 11/14 04/13 04/14 06/13 04/13 05/15 03/12 04/13 04/15 04/13 04/13 04/13 04/12 04/15 03/14

Candidate Ph.D. M.D./Ph.D. Ph.D. Ph.D. M.D./Ph.D. M.D./Ph.D. M.D./Ph.D. M.D./Ph.D. M.S. Ph.D. Ph.D. Ph.D. Ph.D. M.D./Ph.D. M.D./Ph.D. Ph.D. M.D./Ph.D. Ph.D. Ph.D. Ph.D. Ph.D. Ph.D. M.D./Ph.D. Ph.D. Ph.D. Ph.D. Ph.D. Ph.D. M.D./Ph.D. Ph.D.

Requirements Fulfilled 01/15 01/14 04/15 Transferred to J. Hopkins Transferred to J. Hopkins

01/15

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c. Postdoctoral Fellows Ishfaq Ahmed, Ph.D. Aritra Bhattacherjee, Ph.D. Pavla Brachova, Ph.D. Prasad Danawate, Ph.D. Gaurav Fnu, Ph.D. Faezeh Koohestani, Ph.D. Deep Kwarta, Ph.D. Colin McCoin, Ph.D. E. Matthew Morris, Ph.D. Parthasarathy Rangarajan, Ph.D. Badal Roy, Ph.D. Scott Sands, Ph.D. Lesya Holets, Ph.D.

d. Temporary Students Ganesh Aruna Julia Balmaceda Cameron Banning Joseph Blond Shaon Borosha Nitish Chaimalakondia Nicholas Duethman Olivia Eller Saurabh Harohalli Manahil Khan Aishwarya Kumar Melissa Krystel-Whittemore Camron Myers Colton Nielson Pranav Rao Anamika Ratri Avani Sharma Kavya Shivashankar Bethany Snyder Yashi Wang Kathleen White David Wilson Zainab Afsal

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e. Research Staff Janna Belousova – Senior Research Asst. Illya Bronshteyn – Research Associate Anuradha Chakrabarty – Senior Scientist Sornakala Ganeshkumar – Research Asst. Ian Graham – Research Technician Naomi Holloway, Research Associate Xiaoman Hong – Senior Research Assoc. Dora Krizsan-Agbas – Senior Scientist Zhaohui Liao – Research Associate Jacob May – Technician Jeff McDermott – Research Associate Sivapriya Ponnurangam – Research Assoc. Satheest Sainathan – Senior Scientist Sarah Tague – Senior Scientist Gladis Sanchez – Research Associate David Standing – Research Technician Shuan Sheila Tsau – Research Assistant Suwen Wei – Senior Research Associate Joshua Wheatley – Research Assistant Huizhen Wang – Senior Scientist Ying Mu – Research Associate

f. Support Staff Lynn LeCount– Managing Editor Jennifer McNichols – Editorial Coordinator Shari Standiferd – Director of Operations Jennifer Wallace – Accountant Charlotte Weber – Accountant Sara Verga – Student Assistant

Delin Ma, M.D. – Research Assistant Julie Allen – Research Associate Lily Gan, MD, Ph.D.–Research Assistant Professor Uma Sharma – Research Assistant Erica Okwuazi – Research Technician Eric Yarns – Research Assistant

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Notes Concerning Graduate Students Amanda Brinker completed her third year as a graduate student. She co-authored an article entitled “Zinc Finger Nuclease-Mediated Gene Knockout Results in Loss of Transport Activity for P-glycoprotein, BCRP, and MRP2 in Caco-2 Cells” published in Drug Metabolism and Disposition and co-authored an entry currently in press for Encyclopedia of Cancer entitled “BRMS1”. She presented her talk “A Role for Mitochondria in Metastatic Cancer” at the METAvivor Sea to Sea for MBC event. She was first author on an abstract entitled “Effect of mitochondrial haplotype on tumor formation and metastasis” presented as a poster at the 2014 University of Kansas Cancer Research Forum. She was first author on an abstract entitled “Mitochondrial haplotype effects on tumor formation and metastasis are both cell autonomous and non-cell autonomous” which she presented as a poster at the 2015 American Association for Cancer Researchers (AACR) Annual Meeting in Philadelphia, and as a talk at the 2015 Student Research Forum at the University of Kansas Medical Center. She presented her talk “A long and winding road: My journey to industry and back” at the 2015 AACR Undergraduate Symposium where she also served as an invited panelist. Additionally, she was honored with a 2015 AACR-Woman in Cancer Research Scholar Award in February of 2015, and was awarded a Susan G. Komen Kansas Affiliate Travel Award for attendance to the annual meeting. She was recently awarded a Biomedical Research Training Program Fellowship for 2015-2016. Joshua Curry was accepted to attend the Tutored Research and Education for Kidney Scholars (TREKS) program at the Mount Desert Island Biologic Laboratory in Bar Harbor, Maine. As a part of this he received a travel award to attend the 2015 Kidney Week, sponsored by the American Society of Nephrology. Mina Farahbakhsh presented her talk “Regulation of REST Target Genes and miRNA29 in Uterine Leiomyomas” at the 2015 University of Kansas Medical Center Student Research Forum. She also presented posters of “Regulation of REST Target Genes in Uterine Fibroids” at the 2014 Greenwald Symposium and the 2015 Kansas IDeA Network of Biomedical Research of Excellence. At the 2015 Society for the Study of Reproduction and 2015 Iowa State Stupka Symposium she presented posters titled “Role of REST Target Genes in the Pathogenesis of Uterine Leiomyomas.” She was active in the 2014-2015 Student Governing Council, and representative of the Graduate Student Council. She served as the President of the Physiology Society. Farahbakhsh received a SGC travel award spring 2015, as well as The Larry Ewing Memorial Trainee Travel Fund (LEMTTF), and FY16 BRTP (Biomedical Research Training Program) awards.

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Kelsey Hampton served as Physiology Society Vice President until December of 2014, when she then became the group’s Social Chair. In November 2014, she presented a poster at the University of Kansas Cancer Center Retreat entitled “Differential Metastatic Efficacy of Alternate Kisspeptins.” At the Student Research Forum in March 2015, Kelsey gave a seminar entitled “Metastasis Suppression by Non-KP54 Kisspeptins” and tied for First Place in her session. Kelsey was awarded a Physiology Society Travel Award and a Susan G. Komen Travel Award to attend the American Association for Cancer Research Annual Meeting in Philadelphia, PA to present her poster “Metastasis Suppression by Non-KP54 Kisspeptins.” At this meeting, she was awarded a Women in Cancer Research Scholar Award. As a co-author with her mentor, Dr. Danny Welch, Kelsey published an article entitled “KiSS-1: Metastasis Suppressor” in the Encyclopedia of Cancer, which is currently in press. In April 2014, Kelsey was chosen to serve as a committee member for the AACR Associate Member Council-led Communications Committee to develop blog posts and communication strategies for the organization. Erin Hayes Won the 1st place in the 2015 Annual Student research forum oral presentation, section G at KUMC. Asona Lui passed her comprehensive exam and was the co-author on a paper entitled “Targeting interferon stimulated genes sensitizes aromatase inhibitor-resistant breast cancer cells to estrogen induced apoptosis.” She was designated a Minority Scholar in Cancer Research at AACR 2015, where she presented a poster titled “Overexpression of interferon stimulated genes is critical for the survival of aromatase inhibitor-resistant breast cancer cells” and was the recipient of a seed grant by the American Medical Association Foundation. Asona was selected to present a poster at the Capitol Graduate Research Summit and received 1st place among KUMC students, earning her a scholarship from the Kansas Legislature. Asona was recently awarded a Biomedical Research Training Program Fellowship for 2015-2016. Michelle McWilliams presented a selected oral presentation at the Gilbert S. Greenwald Symposium for Reproduction and Regenerative Medicine, titled The Role of PRICKLE-1 in the Pathogenesis of Uterine Leiomyoma. At the 2015 KUMC Student Research Forum, she was awarded the Bob Klein Award for the Best Three-Minute-Thesis presentation, titled Uterine Fibroids: A Detective Mystery, as well as a First Place Award for her presentation The Role of GPR10 and the loss of REST in the Pathogenesis of Uterine Leiomyoma. Michelle served as the student representative on the KUMC Research Advisory Council. She also served on the planning committee for the Greenwald Symposium.

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Danny Miller was first author on a commentary titled “Tetrad analysis in the mouse” published in Nature Genetics. He was also co-author on a manuscript titled "Synaptonemal complex extension from clustered telomeres mediates full-length chromosome pairing in Schmidtea mediterranea” published in PNAS. Danny was also TA for the Advanced Drosophila Genetics and Genomics course at the Welcome Trust in Hinxton, UK, and TA for the Computational and Comparative Genomics course at CSHL. Lei Pei was first author on two poster presentation in 2015 American society of Nephrology "Claudin-2 Null Mice Reveal Increased Renal Transcellular Na Transport And Kidney Oxygen Consumption" and 2015 American society of Nephrology entitled "Paracellular Na[sup]+[/sup] Transport by Claudin-2 Enhances the Efficiency of Oxygen Usage by the Kidney and Protects against Ischemic Injury". She received 800 dollars Kidney STARS travel award to attend 2015 American Society of Nephrology. She also won the second place on 2015 Annual Student research forum oral presentation, section F in KUMC. Maggie Pruitt was awarded a National Research Service Award (NRSA) from NCI, NIH on her project titled, "The randomization of the telomerase RNA template to define the role of telomere sequence in telomere structure, function, and cellular survival." Maggie presented a first author poster at the April Cold Spring Harbor Laboratory Telomeres and Telomerase meeting entitled, "In Flask Evolution of Chromosome End Sequences." She also presented a talk at the Student Research Forum entitled," A Competitive Growth Experiment Reveals Patterns in Mutant Telomerase RNA Template Sequences." Lastly, Maggie passed her comprehensive exam last spring.

Archana Raman was a co-author on a paper entitled "Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease", published in Journal of American Society of Nephrology. She was also the lead author on an abstract entitled "Integrin Linked Kinase Promotes Cyst Growth and Fibrosis in ADPKD" selected for poster publication in the Journal of the American Society of Nephrology. Archana was also awarded the Biomedical Research Training Program (BRTP) fellowship for the year 2015-2016 for her research application entitled “The role of ILK in periostin-induced cyst growth and fibrosis in PKD”. At the Student Research Forum 2015, she was awarded first place for her presentation entitled "Periostin Activation of Integrin-Linked Kinase Promotes Epithelial Cell Proliferation and Cyst Growth in Polycystic Kidney Disease".

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Robert Rogers was first author of a manuscript published in the Journal of Applied Physiology entitled: Heat Shock Proteins: in vivo heat treatments reveal adipose tissue depot-specific effects. Robert was co-author of a manuscript published in Brain Research entitled: Effects of discontinuing a high-fat diet on 6-hydroxydopamine-induced nigrostriatal dopamine depletion in rats. Robert presented a poster at the American College of Sports Medicine’s Integrative Physiology of Exercise Conference in Miami, Florida entitled: Heat shock protein expression levels are lower in skeletal muscle of rats selectively bred to be low capacity runners. Robert also presented a lecture at the Biomedical Research Training Program Symposium entitled: Heat treatment protects against skeletal muscle insulin resistance following a short-term dietary challenge in rats selectively bred as low capacity runners. Jessica Venugopal served as co-chair of the Photography and Publicity Committee for the 2015 KUMC Student Research Forum. She also gave an oral presentation at the Student Research Forum entitled: “Ouabain enhances apoptosis in ADPKD cells via the intrinsic pathway.” Jessica also participated in the inaugural 3 Minute Thesis Competition, with an oral presentation entitled: “Autosomal dominant polycystic kidney disease and the hormone ouabain.” Jessica is also a co-author on a paper entitled: “Ouabain regulates CFTR-mediated anion secretion and Na,K-ATPase transport in ADPKD cells” accepted in the Journal of Membrane Biology. Ashley Ward completed her second year as a graduate student. She was a part of the Food is Medicine group on campus that received the KUMC Student Organization Award and she successfully passed her comprehensive exams.

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COURSES TAUGHT

Medical Curriculum Core Courses CORE 815 – Cardiopulmonary. Dr. Geiger, Dr. Gonzalez, Dr. Smith, and Dr. Wood CORE 820 – Gastrointestinal Tract and Nutrition. Dr. LeVine CORE 825 – Renal and Endocrine System. Dr. Blanco and Dr. Wolfe CORE 830 – Reproduction and Sexuality. Dr. Albertini, Dr. Tash, and Dr. Wolfe CORE 840 – Brain and Behavior. Dr. Cheney, Dr. Frost, Dr. LeVine, and Dr. Stanford CORE 860 – Integration and Consolidation, Dr. Blanco, Dr. Gonzalez and Dr. Wood Departmental Graduate Courses PHSL 834 – Reproductive Physiology. Dr. Albertini, Dr. Chennathukuzhi, Dr. Christenson, Dr. Kumar, Dr. Nothnick, Dr. Wolfe (Not taught this year) PHSL 835 – Integrative Physiology of Exercise. Dr. Geiger, Dr. Gonzalez PHSL 842 – Comprehensive Human Physiology. Dr. Belousov, Dr. Blanco, Dr. Geiger, Dr. LeVine, Dr. Wolfe, Dr. Umar, Dr. Wood PHSL 846 – Advanced Neuroscience. Dr. Cheney, Dr. Enna, Dr. Frost, Dr. Lee, Dr. Smith and Dr. Stanford PHSL 848 – Molecular Mechanisms of Neurological Disorders. Dr. Enna, Dr. LeVine, Dr. Nudo, Dr. Stanford IGPBS Courses GSMC 851 – Molecular Genetics. Dr. Chennathukuzhi, Dr. Christenson, Dr. Umar GSMC 853 – Cellular Structure. Dr. Belousov and Dr. Blanco GSMC 854 – Cell Communication. Dr. Albertini GSMC 852 – Introduction to Biomedical Research Dr. Christenson GSMC 856 – Introduction to Research Ethics Dr. Wolfe

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DEPARTMENT SEMINARS The Department Seminar program was directed by Dr. John Stanford. Thirty six speakers made presentations, thirteen of which were from outside the university. In addition to support from the department, Abrahams J. Hambleton Lectureship in Physiology Endowment Fund, Kathleen M. Osborn Memorial Lectureship in Physiology Endowment Fund, the Office of the Dean of the School of Medicine, the KIDDRC, Landon Center of Aging and the Center for Reproductive Sciences made important financial contributions to our program. 09/03/14 Kayla Raider Effects of a high fat diet on brain Graduate Student metabolism in rats: An in vivo Molecular & Integrative Physiology 1H-MRS study KUMC 09/08/14 Lori Raetzman, Ph.D. Pituitary Gland Development: Associate Professor Kickin’ it up a Notch Molecular & Integrative Physiology University of Illinois at Urbana Champaign Urbana, IL 09/15/14 Jingsong Zhou, Ph.D. Mitochondria, Ca Signaling and Professor of Physiology Neuromuscular Disease Kansas City University of Medicine and Biosciences Kansas City, MO 09/22/14 Frank Kruse, MS BTBC and the Enterpreneurial Vice President Ecosystem KU Biosciences & Technology Business Center Kansas City, KS 09/29/14 John P. Thyfault, Ph.D., FACSM Hepatic Mitochondrial “Fitness” Associate Professor of Nutrition and Protection against Fatty Liver and Exercise Physiology Disease Department of Medicine-Division of Gastroenterology and Hepatology University of Missouri- Harry S. Truman VA Hospital-Research Service Columbia, MO

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10/06/14 In-Young Choi, Ph.D. What Can In Vivo NMR Measure Associate Professor of Neurochemical Profiles Tell Us Hoglund Brain Imaging Center About Metabolic Disorders? KUMC 10/13/14 Lei Pei Roles of Claudin-2 in Paracellular Graduate Student Transplant in Renal Proximal Molecular & Integrative Physiology Tubules KUMC 10/20/14 Nash N. Boutros, MD Epilepsy Spectrum Disorders Professor and Chair Department of Psychiatry University of Missouri- Kansas City Kansas City, MO 10/27/14 Archana Raman Role of Integrin-Linked Kinase Graduate Student in Polycystic Kidney Disease Molecular & Integrative Physiology KUMC 11/03/14 John McGinnis Neuronal basis of energy Graduate Student perception and long-term Molecular & Integrative Physiology memory KUMC 11/10/14 Rodney D. Newberry, MD New Roles for Goblet Cells in Associate Professor Intestinal Immunity Division of Gastroenterology Washington University St. Louis, MO 11/17/14 Wei-Ting Hung Extracellular vesicles in ovarian Graduate Student antral follicle: characterization Molecular & Integrative Physiology and function KUMC 11/24/14 Kathleen M. Osborn Memorial Lectureship

Miles Wilkinson, Ph.D. An ancient gene paralog pair that Professor serves as a molecular rheostat Department of Reproductive Medicine University of California, San Diego San Diego, CA

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12/01/14 Amy Cantilena Endoglin in mesenchymal stem Graduate Student cells using the context of Molecular & Integrative Physiology cardiovascular disease: A study KUMC of regenerative and immunologic consequences 12/08/14 Francisco Gonzalez-Lima, Ph.D. Mitochondrial respiration as a Professor (George I. Centennial target for neuroprotection and Professorship) cognitive enhancement Department of Psychology The University of Texas at Austin Austin, TX 12/15/14 Diana M Duffy, Ph.D. Prostaglandin E2 and local Professor and Vice Chair (Research) control of ovulation Department of Physiological Sciences Eastern Virginia Medical School Norfolk, VA 01/6/15 Guangbo Chen Target the adaptability of Graduate Student heterogeneous aneuploidy Molecular & Integrative Physiology populations KUMC 01/12/15 Krishna Dummula MD, MPH, FAAP Intraventricular hemorrhage in Assistant Professor premature infants: Baby steps Department of Pediatrics towards understanding the KUMC mechanism of disease 01/20/15 Lili Pan Telomere architecture and Graduate Student maintenance in Molecular & Integrative Physiology Schizosaccharomyces pombe KUMC 01/26/15 Michelle McWilliams Estrogen regulation of Doctoral Candidate PRICKLE-1 in the pathogenesis Molecular & Integrative Physiology of Uterine Fibroids KUMC 02/02/15 Holly Hull, Ph.D. The role of the in utero Assistant Professor environment in programming Department of Dietetics and Nutrition the offspring phenotype KUMC

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02/09/15 Michael J. Wacker, Ph.D. Kidney-bone-heart crosstalk: Associate Professor cardiovascular effects induced by Department of Basic Medical Science the osteocyte-derived hormone, University of Missouri-Kansas City FGF23 School of Medicine Kansas City, MO 02/16/15 Asma Zaidi, Ph.D. The neuronal calcium pump: Professor a target of brain aging and Department of Biochemistry neurodegeneration Kansas City University of Medicine

and Biosciences Kansas City, MO

02/23/15 Warren Nothnick, Ph.D., HCLD MicroRNAs in endometriosis Professor pathogenesis and treatment: Molecular & Integrative Physiology Dissection the complexity of KUMC the miR451-MIF pathway

03/02/15 Paige C. Geiger, Ph.D. Obesity, insulin resistance and Associate Professor diabetes: Sex differences and Molecular & Integrative Physiology the role of estrogen receptors KUMC 03/09/15 Zijian Xie, Ph.D. Na/K-ATPase, Salt Handling and Investigator and Director Tissue Fibrosis Marshall Institute for Interdisciplinary Research Marshall University Huntington, WV 03/23/15 Qi Chen, Ph.D. Losing and finding our way at C: Assistant Professor Vitamin C in cancer treatment Pharmacology, Toxicology & Therapeutics KUMC 04/06/15 Danny Miller Somatic mosaicism in Turner Graduate Student syndrome and congenital heart Molecular & Integrative Physiology defects KUMC

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04/13/15 Craig Van Horne, MD, Ph.D. Multimodal DBS therapy for Associate Professor Parkinson’s disease: Peripheral Neurosurgery nerve tissue grafts targeted to University of Kentucky reverse disease progression Lexington, KY 04/27/15 Erin Hayes microRNA Sequencing of Graduate Student Long-Term Estrogen Deprived Molecular & Integrative Physiology Breast Cancer Cells Reveals a KUMC Potential Role for miR-181a in Estrogen-Independent Growth 04/27/15 Michael W. Wolfe, Ph.D. Gonadal regulation of growth Associate Professor and metabolism is Molecular & Integrative Physiology ESR1-dependent in rate KUMC 04/27/15 John A Stanford, Ph.D. Neuromuscular effects of Associate Professor targeted strength training in the Molecular & Integrative Physiology SOD1-G93A rat model of ALS KUMC 05/04/15 Steven LeVine, Ph.D. Iron deposition in multiple Professor sclerosis: Experimental models Molecular & Integrative Physiology reveal insight about disease KUMC mechanisms 05/04/15 Shahid Umar, Ph.D. Enteric Pathogens and Disease Associate Professor Pathogenesis Molecular & Integrative Physiology KUMC 05/11/15 Kathleen Gustafson, Ph.D. Developmental Origins- Director of Fetal Programming for Long-Term Magnetoencephalography Health Research Associate Professor Department of Neurology Hogland Brain Imaging Center KUMC 05/18/15 Voyages Seminar “What did you discover?

Norberto Gonzalez, MD Reflections on a lifetime of Professor research in physiology” Molecular & Integrative Physiology KUMC

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PUBLICATIONS a. Manuscripts Published Abel MH, Widen A, Huhtaniemi I, Pakarinen P, Kumar TR, Christian HC (2014) An

investigation into pituitary gonadotrophic hormone synthesis, secretion, subunit gene expression and cell structure in normal and mutant female mice. Journal of Neuroendocrinology, 26: 785-795.

Albertini, D.F. The Mammalian Oocyte. In, Knobil and Neill’s Physiology of Reproduction,Editors-in-Chief Tony M. Plant and Anthony J. Zeleznik, 4th edition doi.org/10.1016/B978-012-397175-3.00002-8

Alwattar AY, Thyfault JP, Leidy HJ. The effect of breakfast type and frequency of consumption on glucose metabolism in overweight/obese late adolescent girls. Eur J of Clin Nutr. 2015 Aug:69(8):885-90

Anderson, R.A., McLaughlin, M., Wallace, W.H.B., Albertini, D.F., Telfer, E.E. (2014). The immature human ovary shows loss of abnormal follicles and increasing follicle developmental competence through childhood and adolescence. Human Reprod. 29: 97-106. (10.1093/humrep/det388)

Arkatkar T, Gupta R, Li W, Yu, JJ, Wali S, Guentzel MN, Chambers JP, Christenson, LK, Arulanandam BP. Murine MicroRNA-214 Regulates Intracellular Adhesion Molecule (ICAM-1) Gene Expression in Genital Chlamydia muridarum Infection (Immunology Apr 10. doi: 10.1111/imm.12470. [Epub ahead of print

Arror, AA, J Habibi, DA Ford, R Nistala, G Lastra, C Manrique, MM Dunham, KD Ford, JP Thyfault, EJ Parks, JR Sowers, and RS Rector. DPPIV inhibition ameliorates western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function. Diabetes. 2015 Jun:64(6): 1988-2001.

Belousov, A.B. and J.D. Fontes, Role of neuronal gap junctions in NMDA receptor-mediated excitotoxicity and ischemic neuronal death. Neural Regeneration Research, invited paper, submitted for publication, 2015.

Bansal A, Hong X, Lee IH, Krishnadath KK, Mathur SC, Gunewardena S, Rastogi A, Sharma P, Christenson LK. 2014. MicroRNA expression can be a promising strategy for the detection of Barrett’s esophagus: A pilot study. Clin Transl Gastroenterol 11;5:e65. PMC4274369

Barad, D. H.Kushnir, V. A.Albertini, D.Gleicher, N. (2015) CDC analysis of ICSI/autism: association is not causation. Human Reprod. 30:1745-46. Hum Reprod. 2015 Jul;30(7):1745-6. doi: 10.1093/humrep/dev104

Barbay S., E.J. Plautz, E. Zoubina, S.B. Frost, S.C. Cramer, R.J. Nudo (2015) Effects of Postinfarct Myelin-Associated Glycoprotein Antibody Treatment on Motor Recovery and Motor Map Plasticity in Squirrel Monkeys. Stroke. 2015 Apr 30. pii: STROKEAHA.114.008088. [Epub ahead of print] PMID: 25931462

Belousov, A.B. and J.D. Fontes, Neuronal gap junction coupling as the primary determinant of the extent of glutamate-mediated excitotoxicity. J Neural Transm, 121(8): 837-46, 2014. PMID: 24178243, PMCID: PMC4007417.

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Bogliolo. L., Murrone, O., Piccinini, M., Ariu, F., Ledda, S., Tilocca, S. and Albertini, D.F. (2014). Evaluation of the impact of vitrification on the actin cytoskeleton of in vitro matured ovine oocytes by means of Raman microspectroscopy. J Assist Reprod Genet DOI 10.1007/s10815-014-0389-7

Brauer MM, Smith PG. (2015) Estrogen and female reproductive tract innervation: cellular and molecular mechanisms of autonomic neuroplasticity. Autonomic Neuroscience: Basic and Clinical 187: 1-17.

Chandrakesan P, Roy B, Jakkula LU, Ahmed I, Ramamoorthy P, Tawfik O, Papineni R, Houchen C, Anant S, Umar S. (2014) Utility of a bacterial infection model to study epithelial-mesenchymal transition, mesenchymal-epithelial transition or tumorigenesis. Oncogene. 2014 May 15;33(20):2639-54. doi: 10.1038/onc.2013.210.

Chandrakesan P, Weygant N, May R, Qu D, Chinthalapally HR, Sureban SM, Ali N, Lightfoot SA, Umar S, Houchen CW. (2014) DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition. Oncotarget, 5: 9269-9280. PMID: 25211188.

Choi IY, Lee P, Denney DR, Spaeth K, Nast O, Ptomey L, Roth AK, Lierman JA, Sullivan DK. Dairy intake is associated with brain glutathione concentrations in older adults. Am J Clin Nutr 2015;101(2):287-93 PMID: 25646325

Coticchio, G, Gugliemo, M.C., Albertini, D.F., Dal Canto, M., Mignini Renzini, M. De Ponti, E. Fadini, R. (2014). Contributions of the actin cytoskeleton to the emergence of polarity during maturation in human oocytes. Molec. Human Reprod. 20:200-207. (10.1093/molehr/gat085)

Coyan G, Moncure M, Thomas JH, and Wood JG. Induced Hypothermia During Resuscitation from Hemorrhagic Shock Attenuates Microvascular Inflammation In The Rat Mesenteric Microcirculation. Shock 42:518-24, 2014.

Crissey JM, Padilla J, Vieira-Potter VJ, Thorne PK, Koch LG, Britton SL, Thyfault JP, Laughlin MH. Physiol Rep. 2015 Jul:3(7).

Darling, W.G., R.J. Morecraft, D.L. Rotella, M.A. Pizzimenti, J. Ge, K.S. Stilwell-Morecraft, H. Zhang, H. Soliman, D. Seecharan, I. Edwards, D. McNeal, R.J. Nudo and P. Cheney (2014) Recovery of precision grasping after motor cortex lesion does not require forced use of the impaired hand in Macaca mulatta. Experimental Brain Research, 232(12):3939-38. PMCID: PMC4241169.

Davis JS, Kumar TR, May JV and Bousfield GR (2014) Naturally occurring Follicle-Stimulating hormone glycosylation Variants, J Glycomics and Lipidomics 4: e117-e121 (Invited & non-peer reviewed).

E Matthew Morris, MR Jackman, GC Johnson, TW Liu, JL Lopez, ML Kearney, JA Fletcher, G.M.E. Meers, LG Koch, SL Britton, RS Rector, JA Ibdah, PS MacLean, and JP Thyfault. Intrinsic Aerobic Capacity Impacts Susceptibility to Acute High-fat Diet-induced Hepatic Steatosis. Am J Physiol Endocrinol Metab. 2014 Aug 15:307(4):E355-64.

Enna, S.J. Characterization of GABA Receptors. In: Current Protocols in Pharmacology (S.J. Enna and M.J. Williams, eds.), Doi 10.1002/0471141755.ph0107s63, 2014.

Enna, S.J. (Series Editor), James Hardwick (Volume Editor). The P450 Function and Pharmacological Roles in Inflammation and Cancer. Advances in Pharmacology, Vol. 74, 473pp., Academic Press, New York, 2015.

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Enna, S.J. (Series Editor), Thomas P. Davis (Volume Editor). Pharmacology of the Blood-Brain Barrier: Targeting CNS Disorders. Advances in Pharmacology, Vol. 71, 495 pp., Academic Press, New York, 2014.

Enna, S.J. (Series Editor), Uwe Rudolph (Volume Editor). Diversity and Functions of GABA Receptors: A Tribute to Hanns Mohler, Part A. Advances in Pharmacology, Vol. 72, 266 pp., Academic Press, New York, 2015.

Enna, S.J. (Series Editor), Uwe Rudolph (Volume Editor). Diversity and Functions of GABA Receptors: A Tribute to Hanns Mohler, Part B. Advances in Pharmacology, Vol. 73, 270 pp., Academic Press, New York, 2015.

Fontes, J.D., J. Ramsey, J.M. Polk, A. Koop, J.V. Denisova, and A.B. Belousov, Death of neurons following injury requires conductive neuronal gap junction channels but not a specific connexin. PLOS ONE, 10(5): e0125395, 2015. PMID: 26017008; PMCID: PMC4446213.

Franciosi, F., Coticchio, G., Lodde, V., Tessaro, I., Modina, SC., Fadini, R., Dal Canto, B., Renzini, MM., Albertini, DF., Luciano, AM. (2014). Natriuretic Peptide Precursor C Delays Meiotic Resumption and Sustains Gap Junction-Mediated Communication in Bovine Cumulus-Enclosed Oocytes. Biol. Reprod. 91:1-9. DOI 10.1095/biolreprod.114.118869

Frost, S.B., C. Dunham, S. Barbay, D. Krizsan-Agbas, M.K. Winter, D. Guggenmos and R.J. Nudo (2015) Output properties of the cortical hindlimb motor area in spinal cord-injured rats. Accepted, Journal of Neurotrauma.

Gaurav Fnu, Venugopal A, Ramamoorthy P, Standing D, Subramaniam D, Umar S, Jensen R, Anant S, Mammen J. (2014) Honokiol inhibits Melanoma Stem Cells by targeting Notch Signaling. Molecular Carcinogenesis, Dec 9. doi: 10.1002/mc.22242. PMID: 25491779.

Gawriluk TR, Ko C, Hong X, Christenson LK, and Rucker EB 3rd. 2014. Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor. Proc Natl Acad Sci USA 2014 Oct 7:111(40):E4194-203.

Gleicher, N, Barad, D, Albertini, D., Kushnir, V. 2015. Is there an androgen level threshold for aneuploidy risk in infertile women? Reproductive Biology and Endocrinology doi:10.1186/s12958-015-0034-z

Graham A, Falcone T, Nothnick WB. (2015) The expression of microRNA-451 in human endometriotic lesions is inversely related to that of macrophage migration inhibitory factor (MIF) and regulates MIF expression and modulation of epithelial cell survival. Hum Reprod 30:642 – 52.

Greiner AK, Papineni RV, Umar S. Natural Products and Microbiome. (2014) Am. J. Physiol. Gastrointest. Liver Physiol. 307: G1-G15. PubMed PMID: 24789206.

Griffin, D.M., Hudson, H.M., Belhaj-Saif, A. and Cheney, P.D. EMG activation patterns associated with high frequency, long-duration intracortical microstimuation of primary motor cortex. J. Neurosci. 34: 1647-1656, 2014. PMID: 24478348

Gupta V, Holets-Bondar L, Roby KF, Enders G, Tash JS. A tissue retrieval and postharvest processing regimen for rodent reproductive tissues compatible with long-term storage on the International Space Station and postflight Biospecimen Sharing Program. Biomed Res Int 2014; epub at http://www.hindawi.com/journals/bmri/aa/475935/cta/:1-12.

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Hester CM, Jala VR, Langille MG, Umar S, Greiner KA, Haribabu B. (2015) Fecal

microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups. World Journal of Gastroenterology, 21(9): 2759-69. PMID: 25759547.

Hinton, PS, Nigh M, Thyfault, JP. Effectiveness of resistance training or jumping-exercise to increase bone mineral density in men with low bone mass: a 12-month randomized, clinical trial. Bone. 2015 Oct:79:203-12

Hudson, H.M., Griffin, D.M., Belhaj-Saif, A. and Cheney, P.D. Properties of primary motor cortex output to hindlimb muscles in the primate. J Neurophysiol. 113 (3): 937-949, 2015. PMID: 25411454

J Jiang, LJ Boyle, CR Mikus, DJ Oberlin, JA Fletcher, JP Thyfault, PS Hinton. The effects of improved metabolic risk factors on bone turnover markers after 12 weeks of simvastatin treatment with or without exercise. Metabolism. 2014 Nov:63(11): 1398-408

JP Thyfault, M Du, WE Kraus, JA Levine, FW Booth. Physiology of sedentary behavior and its relationship to health outcomes. Med Sci Sports Exerc. Accepted July 2014.

Kaushik, G., Kwatra, D., Subramaniam, D, Anant, S. and Mammen, J.M.V. Honokiol affects melonoma cell growth by targeting the AMPK signaling pathway. The American Journal of Surgery. 2014 Dec;208(6):995-1002. Epub 2014 Oct 2.

Kaushik, G., Venugopal, A., Ramaoorthy, P., Standing, D., Subramaniam, D, Umar, S., Jensen, R.A., Anant, S. and Mammen, J.M.V. Honokiol inhibits Melonoma stem cells by targeting Notch Signaling. Molecular Carcinogenesis. Dec 9. PMID: 25491779

Kim J, Choi IY, Dong Y, Wang WT, Brooks WM, Weiner CP, Lee P, Chronic fetal hypoxia affects axonal maturation in guinea pigs during development: a longitudinal Diffusion Tensor Imaging and T2 mapping study, J Magn Res Imag (2015) 42(3):658-65 PMID: 25504885

Kumar TR (2014) Been Hit Twice: a novel bi-allelic heterozygous mutation in LHCGR, Special Editorial Commentary, Journal of Assisted Reproduction and Genetics 31:783-786 (Invited & non-peer reviewed).

Kumar TR (2014) Extra-gonadal FSH receptor: Is it real? Commentary, Biology of Reproduction,91: 1- 4.

Kumar TR (2014) The quest for male germline stem cells: Pax7 gets ID’d, Commentary, Journal of Clinical Investigation, 124: 4219-4222.

Kushnir, V. A.Halevy, N.Barad, D. H.Albertini, D. F.Gleicher, N.(2015)Relative importance of AMH and androgens changes with aging among non-obese women with polycystic ovary syndrome. J. Ovarian Res. 8: 45-58. 10.1186/s13048-015-0175-x

Latre de Late, Abeer EL Wakil, Marielle Jarjat, Ronald R. de Krijger, Leslie L. Heckert, Philippe Naquet, Enzo Lalli (2014) Steroidogenic Factor 1 and its target gene Vanin-1 functionally interact to modulate adrenocortical tumorigenesis in mice. Endocrinology. 2014 Jul;155(7):2349-54. (Epub 2014 Apr 8).

Leslie L. Heckert and Valentine A. Agbor (2015) “DMRT1 and the Road to Masculinity”. In: Sertoli Cell Biology, 2nd Edition (M.D. Griswold Editor) Elsevier Academic Press, San Diego. pp. 123-174

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Liao Z and Smith PG. (2014) Persistent genital hyperinnervation following progesterone administration to adolescent female rats. Biology of Reproduction 91: 144,1-9.

LJ Reynolds, DP Credeur, SW Holwerda, HJ Leidy, PJ Fadel, JP Thyfault. Acute inactivity impairs glycemic control but not blood flow to glucose ingestion. Med Sci Sports Exerc. 2015 May;47(5):1087-94

A Linden, JR Fletcher, EM Morris, GM Meers, MH Laughlin, FW Booth, JR Sowers, JA Ibdah, JP Thyfault, and RS Rector. Treating NAFLD in OLETF rats with vigourous-intensity interval exercise training. Med Sci Sports Exerc. 2015 Mar;47(3):556-67

Ma D, Shuler JM, Raider KD, Rogers RS, Wheatley JL, Geiger PC, Stanford JA (2015) Effects of discontinuing a high fat diet on mitochondrial proteins and 6-hydroxydopamine-induced dopamine depletion in rats. Brain Research. 1613, 49-58.

McCarson, K.E. and Enna, S.J. GABA Pharmacology: The Search for Analgesics. Neurochemical Research 39:1948-1963, 2014.

McDermott JP, Sánchez G, Nangia A.K. and Blanco G. Role of human Na,K-ATPase alpha4 in sperm function derived from studies in transgenic mice. (2015). Mol. Reprod. Dev. 82(3):167-181.

McGinnis, L.K., Luense L., and L.K. Christenson. 2015. MicroRNA in Ovarian Biology and Disease. In: Perspectives in Medicine Reproductive Sciences; Eds. Diana W. Bianchi & Errol R. Norwitz. Cold Spring Harbor. 2015 May 18. pii: a022962. doi: 10.1101/cshperspect.a022962. [Epub ahead of print]

Microbiome: Microbial mystery, Nature 521, S10-S11 (14 May 2015) doi: 10.1038/521S10a.

Mullane, K., Enna, S.J., Piette, J. and Williams, M. Guidelines for Manuscript Submission in the Peer-Reviewed Pharmacological Literature. Biochemical Pharmacology, in press.

Neradugomma, N.K., Sainathan, S., Baranda, J., Subramaniam, D. and Anant, S. (2014). Role of prolactin and its receptor in colorectal cancer. Current Colorectal Cancer Reports 10(4);453-462 Epub 2014, Sep 27.

Neradugomma N, Subramaniam D, Tawfik O, Goffin V, Kumar TR, Roy J and Anant S (2014) Prolactin induces Notch signaling in a Jak2-STAT and Jak2-ERK pathways in colon cancer stem and progenitor cells. Carcinogenesis, 235: 795-806.

Nothnick WB, Al-Hendy A, Lue J. (2015) Circulating microRNAs as diagnostic biomarkers for endometriosis: privation and promise. J Minim Invasive Gynecol. 22:719 – 26.

Nothnick WB. (2015) Endometriosis: Bright future for a cloudy past? Sci Transl Med. 7:271fs.

Nyhoff LM, Heden TD, Leidy HJ, Winn NC, Park YM, Thyfault JP, Kanaley JA. Prior exercise does not alter the incretin response to a subsequent meal in obese women. Peptides. 2015 Jul 15:71:94-99.

Olesen SH, Ingles DJ, Zhu JY, Martin MP, Betzi S, Georg GI, Tash JS, Schonbrunn E. Stability of the human Hsp90-p50Cdc37 chaperone complex against nucleotides and Hsp90 inhibitors, and the influence of phosphorylation by casein kinase 2. Molecules 2015; 20:1643-1660.

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Padilla J, Olver TD, Thyfault JP, Fadel PJ. Role of habitual physical activity in

modulating vascular actions of insulin. Exp Physiol. 2015 Jul 1:100(7):759-71. Park YM, Heden T, Liu Y, Nyhoff L, Thyfault JP, Leidy HJ, and Kanaley J. High protein

breakfast induces greater insulin and glucose-dependent insulinotropic peptide responses to subsequent lunch meal in individuals with type 2 diabete; J. Nutr. 2015 Mar: 145(3):452-8.

Paul, S., Ramalingam, S., Subramaniam, D., Baranda, J., Anant, S. and Dhar, A. (2014). Histone Demethyalses in colon cancer. Current Colorectal Cancer Reports 2014 Dec 1;10(4):417-424. PMID: 25574158

Picklo MJ, Thyfault JP. Vitamin E and vitamin C do not reduce insulin sensitivity but inhibit mitochondrial protein expression in exercising obese rats. Appl Physiol Nutr Metab. 2015 Apr:40(4):343-52.

Ramalingam, S., Subramaniam, D. and Anant, S. (2015). Manipulating miRNA Expression: A Novel Approach for Colon Cancer Prevention and Chemotherapy. Current Pharmacological Reports 2015 Jun 1;1(3):141-153. PMID: 26029495

Ramamoorthy P, Satish R, Dharmalingam S, Prasad D, Ossama T, Roy A J, Joaquina CB, Scott JW, Mojtaba SO, Subhash P, Gurusingham SS, Shrikant A. A Novel “Tumor in a Dish” Method to Study Primary and Metastatic Colon Cancer; Differential Therapeutic Responses in Cancers With Mismatch Repair Defects. Gasteroenterology, 2015, April 148:4 supplement 1 , S-63-S-64.

Rangarajan, P., Subramaniam, D., Paul, S., Kwatra, D., Palaniyandi, K., Islam, S., Harihar, S., Ramalingam, S., Gutheil, W., Puddy, S., Pradhan, R., Padhye, S., Welch, D.R., Anant, S and Dhar, A. (2015). Purified crocetinic acid derived from Saffron inhibits tumor progression targeting cancer stem cells in pancreatic cancer. Oncotarget. 2015 Aug 13. [Epub ahead of print]. PMID: 26317547

Rao D, Kimler BF, Nothnick WB, Davis M, Fan F, Tawfik O. (2015) Transgelin: A potentially useful diagnostic marker differentially expressed in triple-negative and non-triple negative breast cancers. Hum Pathol 46:876 – 83.

Rocha SC, Pessoa MT, Neves LD, Alves SL, Silva LM, Santos HL, Oliveira SM, Taranto AG, Comar M, Gomes IV, Santos FV, Paixão N, Quintas LE, Noël F, Pereira AF, Tessis AC, Gomes NL, Moreira OC, Rincon-Heredia R, Varotti FP, Blanco G, Villar JA, Contreras RG, Barbosa LA. 21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions. PLoS One. 2014 Oct 7;9(10):e108776.

Rogers RS, Soleil-Boudin M, Morris JK, Wheatley JL, Wright DC, Geiger PC (2015). Heat shock proteins: in vivo heat treatments reveal adipose tissue depot-specific effects. Jan 1;118(1):98-106. PMID: 25554799

Ronca AE, Baker ES, Bavendam TG, Beck KD, Miller VM, Tash JS, Jenkins M. Effects of sex and gender on adaptation to space: Reproductive considerations. J Womens Health (Larchmt) 2014; 23:967-974.

Roy BC, Subramaniam D, Ahmed I, Jala VR, Hester C, Greiner KA, Haribabu B, Anant S, Umar S. (2014) Role of bacterial infection in the epigenetic regulation of Wnt antagonist WIF1 by PRC2 protein EZH2. Oncogene, Dec 8. doi: 10.1038/onc.2014.386. PMID: 25486432.

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Rudolph, U. and Enna, S.J. Preface: A Tribute to Professor Hanns Mohler. In: Diversity and Functions of GABA Receptors: A Tribute to Hanns Mohler, Part A, ix-xii, Academic Press, New York, 2015.

Sainathan, S.K., Paul, S., Ramalingam, S., Baranda, J., Anant, S. and Dhar, A. (2015). Histone Demethyalses in cancer. Current Pharmacological Reports (2015) 1:234–244

Sands, SA, Tsau, S, Yankee, TM, Parker, BL, Ericsson, AC, and LeVine, SM (2014) The effect of omeprazole on the development of experimental autoimmune encephalomyelitis in C57BL/6J and SJL/J mice. BMC Res. Notes 7:605.

Sanfins, A., Plancha, C.E., Albertini, D.F. (2014). Pre-implantation developmental potential from in vivo and in vitro matured mouse oocytes: a cytoskeletal perspective on oocyte quality. J. Assist. Reprod. Genet. DOI 10.1007/s10815-014-0363-4.

Shahdoost, S., S. Frost, C. Dunham, S. DeJong, S. Barbay, R. Nudo and P. Mohseni (2015) Cortical control of intraspinal microstimulation: Towards a new approach for restoration of function after spinal cord injury. IEEE EMBS Conference Proceedings.

Shahdoost, S, S. Frost, G. Van Acker, S. DeJong, C. Dunham, S. Barbay, R. Nudo, P. Mohseni, (2014) Towards a Miniaturized Brain-Machine-Spinal Cord Interface (BMSI) for Restoration of Function after Spinal Cord Injury. Conf Proc IEEE Eng Med Biol Soc. 2014 Aug;2014:486-9. doi: 10.1109/EMBC.2014.6943634. PMID: 25570002

Shen Q, Holloway N, Thimmesch A, Wood JG, Clancy RL, Pierce JD. Ubiquinol decreases hemorrhagic shock/resuscitation-induced microvascular inflammation in rat mesenteric microcirculation. Physiol Rep. 2:e12199 p 1-8, 2014.

Stanford JA, Shuler JM, Fowler SC, Stanford KG, Ma D, Bittel DC, Le Pichon J-B, Shapiro SM(2015) Hyperactivity in the Gunn rat model of neonatal jaundice: age-related attenuation and emergence of gait deficits. Pediatric Research, 77, 434-439.

Tawfik O, Rao DS, Nothnick W, Graham A, Mau, B, Fan F. (2014) Transgelin, a novel marker that effectively distinguishes endometrial stromal tumors from uterine smooth muscle tumors. IJGORMR 1:26 – 31.

TD Heden, NC Winn, A Mari, FW Booth, RS Rector, JP Thyfault, JA Kanaley. Postdinner resistance exercise improves postprandial risk factors more effectively than predinner resistance exercise in patients with type 2 diabetes. J Appl Physiol. 2015 Mar 1;118(5):624-34.

Tsau, S, Emerson, MR, Lynch, SG, and LeVine, SM (2015) Aspirin and multiple sclerosis. BMC Med. 13:153. (a review paper that has become highly accessed)

Umar S. (2014) Enteric pathogens and cellular transformation: bridging the gaps. Oncotarget, 5: 6573-6575. PMID: 25216513.

Van Acker, G.M. III, Amundsen, S.L., Messamore, W.G., Zhang, H.Y., Luchies, A. and Cheney, P.D. Equilibrium-based movement end-points elicited from primary motor cortex using repetitive microstimulation. J Neurosci. 34(47): 15722-15734. 2014 doi: 10.1523/JNeurosci.0214-14.2014. PMID: 25411500

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Venugopal, A. Subramaniam, D., Balmaceda, J.B., Roy, B., Dixon, DA, Umar, S., Weir, SJ and Anant S. (2015). RNA binding protein RBM3 increases β-catenin signaling to increase stem cell characteristics in colorectal cancer cells. Accepted in Molecular Carcinogenesis.

Vieira-Potter VJ, Padilla J, Park J, Welly R, Scroggins R, Britton S, Koch L, Jenkins NT, Crissey J, Zidon T, Morris M, Meers G, Thyfault JP. Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction. Am J Physiol Reg Integ Comp Physiol.2015 Mar 15:308(6):R530-42.

Wang H, Graham I, Hastings R, Gunewardena S, Brinkmeier ML, Conn PM, Camper SA, Kumar TR (2015) Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects. Journal of Biological Chemistry, 290:2699-2714.

Wang H, Larson M, Shariff AJ, Pearl C, Miller WL, Conn PM, Boime I and Kumar TR (2014) Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function. Proceedings of The National Academy of Sciences (USA), 111: 5735 - 5740.

Warren BD, Kinsey WK, McGinnis LK, Christenson LK, Jasti S, Stevens AM, Petroff BK, Petroff MG. 2014. Ovarian autoimmune disease: clinical concepts and animal models. Cell Mol Immunol. 11(6):510-21. PMC4220844

Yao L, Li Y, Knapp J, Smith P.(2015) Exploration of molecular pathways mediating electric field-directed Schwann cell migration by RNA-seq. J Cell Physiol. 2015 ;230:1515-24

Yesilaltay A, G. Dokshina, D. Bussoc, L. Wanga, D. Galianid, T. Chavarriae, E. Vasilef, L.Quilaqueoc, J. Orellanag, D.Walzera, R. Shalgi, N. Dekel, D.F.Albertini,A.Rigotti, D.C.Page, and M. Krieger (2014). Excess cholesterol induces mouse egg activation and may cause female infertility. Proc. Nat. Acad. Sci. (USA) www.pnas.org/cgi/doi/10.1073/pnas.1418954111

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b. Manuscripts in Press

Bauer LB, Reynolds LJ, Douglas SM, Kearney ML, Hoertel HA, Shafer RS, Thyfault JP, Leidy HJ. A pilot study examining the effects of consuming a high-protein vs. normal-protein breakfast on free-living glycemic control in overweight/obese ‘breakfast skipping’ adolescents. Int J Obes (Lond). In Press

Callahan ZJ, Oxendine M, Wheatley JL, Menke C, Cassell EA, Bartos A, Geiger PC, Schaeffer PJ. Compensatory responses of the insulin signaling pathway restore muscle glucose uptake following long-term denervation. In Press Physiological Reports Apr;3(4). pii: e12359. PMID: 25896980

Chappell I, Sturgeon DL, Lee P, McIff TE, Toby EB, Fischer KJ, Evaluation of MRI relaxation time in wrist cartilage with scapholunate ligament injury, Int J Diagnostic Imaging (in press)

Enna, S.J. and Bylund, D.B. Pharmacology. Reference Module in Biomedical Sciences, Elseveir, in press.

K. Jansson, J. Venugopal, G. Sánchez, B. S. Magenheimer, G. A. Reif, D. P. Wallace, J. P. Calvet and G. Blanco. Ouabain regulates CFTR-mediated anion secretion and Na,K-ATPase transport in ADPKD cells”, Journal of Membrane Biology (in press).

Kantara C., Moya SM, Houchen CW, Umar S, Ulrich RL, Singh P, Carney DH. (2015) Regenerative Peptide TP508 Mitigates Radiation-Induced Gastrointestinal Damage By Activating Stem Cells and Preserving Crypt Integrity. Laboratory Investigation (In Press).

Ma D, Shuler JM, Raider KD, Rogers RS, Wheatley JL, Geiger PC, Stanford JA (2015). Effects of discontinuing a high-fat diet on mitochondrial proteins and 6-hydroxydopamine-induced dopamine depletion in rats. In Press Brain Research Apr 8. pii: S0006-8993(15)00288-7. PMID: 25862572

Messamore, W.G., Van Acker, G.M. III, Zhang, H.Y., Kovac, A., Nazzaro, J.M. and Cheney, P.D. Cortical effects on ipsilateral hindlimb muscles revealed with stimulus-triggered averaging of EMG activity. In press, Cerebral Cortex PMID: 26088970

Nothnick, WB. (2015) Non-coding RNAs in development and disease of the female reproductive tract. Wilhelm, D. Non-coding RNAs and the Reproductive System. Springer, (in press).

Nudo, R.J. and S. Barbay (2015) The mechanisms and neurophysiology of stroke recovery, Chapter 7, In: Stroke Recovery & Rehabilitation, J. Stein, R.L. Harvey, R.F. Macko, C. Winstein, R. Zorowitz, (eds), Demos Medical Publishing, New York, in press

Papineni RVL, Umar S, Brown J, Goltsov A. (2015) Stress visualization in gastrointestinal tract at different pathologies forwards a systems approach to drug repurposing. J. Bioanalysis & Biomedicine (In Press). Editorial

P. S. N. Rowe, L. Zelenchuk, J. S. Laurence, P. Lee, W. M. Brooks, and E. McCarthy. Do ASARM peptides play a role in Nephrogenic Systemic Fibrosis?, Am J Physiol – Renal Physiol (in press)

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Q. Yang, M. Gong, S. Cai, T. Zhang, J. T. Douglas, V. Chikan, N. M. Davies, P. Lee, I.-Y. Choi, S. Ren, M. L. Forrest, Combining hard and soft magnetism into a single core-shell nanoparticle to achieve both hyperthermia and image contrast, Therapeutic Delivery (in press)

Rangarajan, P., Subramaniam, D., Paul, S., Kwatra, D., Palaniyandi, K., Islam, S., Harihar, S., Ramalingam, S., Gutheil, W., Puddy, S., Pradhan, R., Padhye, S., Welch, D.R., Anant, S and Dhar, A. (2015). Purified crocetinic acid derived from Saffron inhibits tumor progression targeting cancer stem cells in pancreatic cancer. In press in Oncotarget.

Sureban SM, May R, Qu D, Chandrakesan P, Weygant N, Ali N, Lightfoot SA, Ding K, Umar S, Schlosser MJ, Houchen CW. (2015) Dietary pectin increases intestinal crypt stem cell survival following radiation injury. PLoS One (In Press).

Tatiana Karpova, Kumarasamy Ravichandiran, Lovella Insisienmay, Daren Rice, Valentine Agbor and Leslie L. Heckert (2015) Steroidogenic factor 1 differentially regulates fetal and adult Leydig cell development in male mice. Biology of Reproduction. In Press

Van Acker, G.M., Griffin, D.M. and Cheney, P.D. Timing of cortico-muscle transmission during active movement. In press, Cerebral Cortex PMID: 26209849

Venugopal, A. Subramaniam, D., Balmaceda, J.B., Roy, B., Dixon, DA, Umar, S., Weir, SJ and Anant S. (2015). RNA binding protein RBM3 increases β-catenin signaling to increase stem cell characteristics in colorectal cancer cells. In press, Molecular Carcinogenesis.

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c. Abstracts

Ahmed I, McLaughlin S, Goltsov, A, Umar S, Papineni RV. (2015) Radiation related gastrointestinal injuries differ during different stress conditions in mouse. 61st Annual Meeting, September 19-22, Weston, FL.

Ahmed I, McLauglin W, Umar S, Papineni RV. (2014) Clostridium cluster XIVa species an early biomarker in radiation injury. American Association for Cancer Research (AACR) Annual Meeting. April 5-9, San Diego, CA.

Ahmed I, BC Roy, Subramaniam D, Kwatra D, Weir S, Dixon D, Anant S, Umar S. (2015) Phytochemicals target epigenetic signaling to block cancer stem cell-driven colon carcinogenesis. American Association for Cancer Research (AACR) Annual Meeting. April 18-22, Philadelphia, PA.

Ahmed, I., Roy, B.C., Subramaniam, D., Tawfik, O.W., Padhye, S.B., Anant, S and Umar, S. Phytochemicals target epigenetic signaling to block cancer stem cell-driven colon carcinogenesis Digestive disease week, Washington, DC, May 2015.

A. J. Hughes, I.-Y. Choi, P. Lee, P. Adany, D. R. Denney, S. G. Lynch, Cognitive Impairment, Oxidative Stress, and Neurodegeneration in MS, the 30th Americas and European Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS-ECTRIMS), Boston, MA, September 10-13, 2014 – poster presentation

Belousov, A.B., J. Ramsey, J.M. Polk, A. Koop, J.V. Denisova, and J.D. Fontes, Death of neurons following injury requires conductive neuronal gap junction channels but not a specific connexin. International Gap Junction Conference (abstracts), Valparaíso, Chile, March 28 - April 1, 2015.

Choi IY, Lee P, Statland J, McVey AL, Dimachkie MM, Brooks WM, Barohn RJ, Reduction in cerebral antioxidant, glutathione (GSH), in patients with ALS: A preliminary study, American Academy of Neurology (AAN) 67th Annual Meeting, P6.105 April 18 – 25, 2015, Washington, DC – poster presentation

Drisko J, Tague S, Ourania S, Winter M, McCarson K, Smith P (2014) The Effects of

Vitamin B6 Deficiency or Supplementation on Cutaneous Sensitivity in Diabetic

and Non-Diabetic Mice. The Journal of Alternative and Complementary Medicine 20: A104.

Enna, S.J. Reproducibility of Data: Facts and Figures. Proc. 17th World Congress of Basic and Clinical Pharmacology, 2014.

Faezeh Koohestani, Michelle McWilliams, Riley Wertenberger, Vargheese Chennathukuzhi. WNT and mTOR pathways in the G-protein coupled receptor 10 (GPR10) transgenic mouse model of uterine fibroids. American Society for Reproductive Medicine 2014 Annual Meeting. Honolulu, Hawaii

Faezeh Koohestani, Michelle McWilliams, Wendy Jefferson, Kavya Shivashankar, Carmen Williams & Vargheese Chennathukuzhi. “WNT/PCP Pathways in the Pathogenesis of Uterine Fibroids” Society for the Study of Reproduction (SSR), San Juan, Puerto Rico, USA, 18–22 June 2015. – Won the Best Poster Award

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Frost S.B., C.L. Dunham , S. Barbay, D.W. McNeal, D. Krizsan-Agbas , M.K. Winter, D.J. Guggenmos R.J. Nudo (2014) The effect of intrapspinal microstimulation parameters on movement thresholds in normal and spinal cord-injured rats. 2014-S-6058-SfN Society for Neuroscience Abstracts 2014.

Heckert PhD, Valentine Agbor PhD, Tatiana Karpova PhD “DMRT1 in Sertoli Cells Regulates Adult Leydig Cell Maturation” Abstract XXIII North American Testis Workshop April 15-18, 2015 Salt Lake City, Utah.

Holets-Bondar LM, Gunewardena S, Knapp J, Tash JS. BION-M1: Space flight for 30d alters the expression of testis- and epididymis-specific genes in male mice. In: American Society for Gravitaional and Space Research, vol. asgsr.org. Pasadena, CA; 2014.

Hung WT, Navakanitworakul, R., McGinnis, L.K. and L.K. Christenson. 2014. Granulosa Cell proliferation differentially regulated by follicular fluid extracellular vesicles (EVs) from early and late antral follicles. 47th Annual Society for Study of Reproduction (Aug, 2014).

Hung WT, Navakanitworakul R, McGinnis LK. Gunewardena S, and LK Christenson. 2015. Follicular Fluid Extracellular Vesicles (EVs) Regulate Cumulus-Oocyte-Complex (COC) Expansion through Preferential Uptake by Cumulus Cells. International Society for Extracellular Vesicles. (April, 2015). Poster (Selected for Oral)

I. Chappell, P. Lee, T. E. McIff, E. B. Toby, K. J. Fischer, Comparing Cartilage T2 Relaxation Times and Joint Contact Pressures of Normal and Injured Wrists, The Biomedical Engineering Society (BMES), San Antonio, TX, October 22-25 (2014) – poster presentation

I.-Y. Choi, J. M. Burns, D. K. Sullivan, H-W Yeh, W. M. Brooks, P. Lee, Correlation between cerebral glutathione, dietary intake and cognitive function in aging and Alzheimer’s disease, Proc Int Soc Magn Reson Med 22, 4320, Toronto, Canada, May 30 - June 5 (2015) – electronic poster presentation

Jeffrey P. McDermott, Gladis Sánchez and Gustavo Blanco. Na,K-ATPase α4, the isoform that supports sperm function and male fertility. 14th International Conference. Na,K-ATPase and related transport ATPases: Structure, mechanism, cell biology, health and disease. Lunteren, The Netherlands, August 2014.

Kubota, Kaiyu, M.A. Karim Rumi, Dramod Dhakal, Wei Cui, Jay L. Vivian, Michael W. Wolfe, Katherine F. Roby and Michael J. Soares. 2014. Hormonal regulation of female reproductive cyclicity. 11th Annual Gilbert S. Greenwald Symposium on Reproduction, Kansas City, KS.

Kyle Jansson, Brenda S. Magenheimer, Darren P. Wallace, James P. Calvet and Gustavo Blanco. Regulation of fluid secretion by ouabain in autosomal dominant polycystic kidney disease. American Society of nephrology, Philadelphia, November 2014.

Leslie L. Heckert, Elizabeth A. Dille, Daren Rice, Aaron Smalter Hall. “A 3’ distal element implicated in cell-specific expression of the follicle-stimulating hormone receptor” Abstract. 48th Annual Meeting of the Society for the Study of Reproduction. June 18-22, 2015 San Juan, Puerto Rico

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Ma D, Shuler JM, Raider KD, Rogers RS, Wheatley JL, Geiger PC, Stanford JA (2014). Effects of discontinuing a high-fat diet on 6-hydroxydopamine-induced dopamine depletion in rats. Poster presented at the 44th Annual Meeting of the Society for Neuroscience in Washington, D.C.

McGinnis LK, , Warren BD,. Jasti S, Christenson LK, Petroff BK, Petroff MG. 2015 Knockout of AIRE (Autoimmune Regulator) gene causes peri-implantation fetal loss and rapid reduction in the ovarian follicular reserve. Society for Reproductive Investigations Annual Meeting. (March 2015)

Michelle M. McWilliams , Faezeh Koohestani, Carmen Williams , Sumedha Gunewardena, T. Rajendra Kumar, Vargheese Chennathukuzhi. Prickle-1 (pk-1) links environmental estrogen exposure to the loss of rest in uterine leiomyoma. American Society for Reproductive Medicine 2014 Annual Meeting. Honolulu, Hawaii

Mina Farahbakhsh, Faezeh Koohestani and Vargheese Chennathukuzhi. “Role of REST Target Genes in the Pathogenesis of Uterine Leiomyomas”. Society for the Study of Reproduction (SSR), San Juan, Puerto Rico, USA, 18–22 June 2015.

Nothnick WB, Graham A, Falcone T. (2015) Up-regulation of endometriotic implant miR451 acts to curtail implant survival in vivo by targeting macrophage migration inhibitory factor, reducing its expression and suppressing cell proliferation: 62nd Annual Meeting for the Society for Reproductive Investigation, March 25th – 28th, 2015, San Francisco, CA. Abstract O-147.

P. Adany, I.-Y. Choi, E. Sherry, P. Lee, Human thalamic structure segmentation with Universal-SHape Interpolation using the Radon Transform (uSHIRT), Proc Int Soc Magn Reson Med 22, 3755, Toronto, Canada, May 30 - June 5 (2015) – electronic poster presentation

P. Adany, I.-Y. Choi, P. Lee, Performance Optimized Lipid Artifact Removal (POLAR) with BASE-SLIM of Full FOV Human Brain 1H MRS, Proc Int Soc Magn Reson Med 22, 4720, Toronto, Canada, May 30 - June 5 (2015) – electronic poster presentation

P. Adany, P. Lee, I.-Y. Choi, Human Brain 1H MRS of GM and WM: a Comparison of BASE-SLIM and CSI Regression, Proc Int Soc Magn Reson Med 22, 4722, Toronto, Canada, May 30 - June 5 (2015) – electronic poster presentation

Preet R, Zhuang S, Hung WT, Christenson LK, and DA Dixon. 2015. Regulation of exosome production and cargo by the RNA-binding proteins HuR and TTP in colon cancer cells. 13th Annual AACR International Conference on Frontiers in Cancer Prevention Research, New Orleans, LA

Ramamoorthy, P., Ramalingam, S., Subramaniam, D., Dantawate, P., Tawfik, O.W., Weir, S.J., Padhye, S.B., Umar, S., Jensen, R.A., and Anant, S. A novel “Tumor in a Dish” method to study primary and metastatic colon cancer; differential therapeutic responses in cancers with mismatch repair defects. Oral Presentation. Digestive disease week, Washington, DC, May 2015.

Rangarajan, P., Ramalingam, S., Subramaniam, D., Baltezor, M.J. Wood, R., Anant, S. and Weir, S.J. Ciclopirox Prodrug for the prevention of Non-Muscle Invasive Bladder Cancer. Poster Presentation. 106th American Association of Cancer Research Annual meeting, Philadelphia, PA, April 2015.

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Rao D, Kimler B, Nothnick WB, Davis M, Fan F, Tawfik O. (2014) Transgelin: A new diagnostic and prognostic marker for triple-negative breast cancer. American College of Pathologists Annual Meeting, Chicago, IL.

Sainathan, S., Paul, S., Palaniyandi, K., Subramaniam, D, Ramalingam, S, Tawfik, O, Iwakuma, T, Welch, D, Padhye, SB, Anant, S and Dhar, A. Histone Demethylase KDM3A: Novel Epigenetic Target for Pancreatic Cancer. Poster Presentation. 106th American Association of Cancer Research Annual meeting, Philadelphia, PA, April 2015.

Shahdoost S., Frost S., Nudo R.,, and Mohseni,P. “A multichannel corticospinal interface IC for intracortical spike recording and distinct muscle pattern activation via intraspinal microstimulation,” in Proc. 57th Annu. Int. IEEE Midwest Symp. Circuits and Systems (MWSCAS’14), pp. 310-313, College Station, TX, August 3-6, 2014.

Shahdoost S., Frost S., Van Acker G., DeJong S., Dunham C., Barbay S., Nudo R., and Mohseni, P., “Towards a miniaturized brain-machine-spinal cord interface (BMSI) for restoration of function after spinal cord injury,” in Proc. 36th Annu. Int. IEEE Eng. Med. Biol. Conf. (EMBC’14), pp. 486-489, Chicago, IL, August 26-30, 2014.

Stanford KG, Shuler JM, Fowler SC, Shapiro SM, Stanford JA (2014) Hyperactivity, gait deficits, and orolingual motor function in the Gunn rat model of neonatal jaundice. Poster presented at the 44th Annual Meeting of the Society for Neuroscience in Washington, D.C.

Stanford JA, Ma D, Shuler JM, Tomohiro T, Sudheer T, Nishimune H (2014). Effects of tongue force training on bulbar motor function in SOD1-G93A rats. Poster presented at the 44th Annual Meeting of the Society for Neuroscience in Washington, D.C.

Subramaniam D, Ponnurangam S, Kwatra D, Kaushik G, Ramamoorthy P, Ramalingam S, Tawfik O, Weir SJ, Padhye S, Dixon DA, Umar S, Jensen RA, Anant S. (2015) Honokiol prevents colonic tumorigenesis and affects stem cell viability by affecting oncogenic YAP1 function. American Association for Cancer Research (AACR) Annual Meeting. April 18-22, Philadelphia, PA.

Subramaniam, D., Ponnurangam, S., Sayed, A., Dhar, A., Dixon, D.A. Tawfik, O.W., Parab, R.R., Ranadive, P., Sharma, R., Mahajan, G., Sugumar, A., Jensen, R.A., Balakrishnan, A., Anant, S. Quinomycin A affects pancreatic cancer stem cells in part through suppression of Notch Signaling Pathway. Poster Presentation 106th American Association of Cancer Research Annual meeting, Philadelphia, PA, April 2015.

Susmita Jasti, Vargheese Chennathukuzhi, Thomas Yankee, Brian K. Petroff and Margaret G. Petroff. Immune response to shared placenta/tumor antigens may reduce cancer risk in parous females. American Society for Reproductive Medicine. October 18th- 22nd, 2014, Hawaii, USA.

Tash JS, Okwuazi E. Preparation of sperm from sea urchins and rat for functional studies on the ISS. In: American Soceity for Gravitation and Space Research, vol. asgsr.org. Pasadena, CA; 2014.

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Van Acker GM, Guggenmos D, Pack A, Dunham C, Nudo RJ (2014) Potentiating functional connectivity between distant cortical locations with activity dependent stimulation in the anesthetized rat. Rehabilitation into the 21st Century Poster Session, Cleveland FES Center, Cleveland, Ohio, October 24, 2014.

Venugopal A, Balmaceda J, Kwatra D, Subramaniam D, Umar S, Anant S. (2014) RBM3 overexpression increases β-catenin signaling activity to induce a cancer stem cell phenotype. American Association for Cancer Research (AACR) Annual Meeting. April 5-9, San Diego, CA.

Wilkins HM, Roy M, Stanford JA, Swerdlow RH (2015) Injecting Mitochondria into Mouse Hippocampi Induces Neuroinflammation and Raises APP Expression. Poster presented at the Alzheimer’s Association International Conference in Washington, D.C.

Zhuang S, Hu L, Sanduja S, Umar S, Anant S, Dixon DA. (2015) The RNA-binding protein Tristetraprolin controls intestinal cell differentiation and tumorigenesis through the Notch signaling pathway. American Association for Cancer Research (AACR) Annual Meeting. April 18-22, Philadelphia, PA.

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RESEARCH SUPPORT D.F. Albertini: ESHE Fund – “Imaging Stem Cells.” December 2014 – December 2015. Annual Direct Costs: $18,000. NIH – “Fertility Preservation in Primates.” May 1, 2015 (Consultant). S. Anant: NIH – “Novel dual Notch/PXR targeting for colon cancer Therapy.” January 1, 2014 – December 31, 2018. Principal Investigator: S. Anant. Annual Direct Cost: $338,869. NIH – “Bitter Melon Component and Colon Cancer Prevention.” August 1, 2014 – December 31, 2018 . Annual Direct Cost: $360,735. A.B. Belousov: NIH/NINDS – “Novel mechanism for glutamate-dependent excitotoxicity”. July 1, 2012-June 30, 2015. Principal Investigator: A.B. Belousov. Annual Direct Costs: $125,000. Alzheimer’s Disease Center/ Landon Center on Aging 2014-2015 Pilot Research Grant Program (KUMC) – “Role of gap junctions in neuronal death in the context of Alzheimer’s disease”. April 1, 2014 – March 31, 2015. Principal Investigator: A.B. Belousov. Annual Direct Costs: $17,000. V.G. Blanco: NIH – “Na,K-ATPase mediated ouabain effects in polycystic kidney disease.” 2009 – 2014. Principal Investigator: G. Blanco. Annual Direct Costs: $250,000. NIH – “Inhibitors of Na, K-ATPhase alpha4 as male contraceptives.” 2014-2019.. Annual Direct Costs: $200,000. NIH – Kansas IDeA network of biomedical Research Excellence. 2014-2019. IRHRM – “Follicular fluid exosomes and microvesicles impact on sperm function.” 2014-2015. Annual Direct Costs: $10,000. P.D. Cheney: NIH-NINDS – “Cortical Control of Hindlimb Muscles in Primates.” March 1, 2009 – February 28, 2015. Principal Investigator: P.D. Cheney. Annual Direct Costs: $1,046,327, Total costs: $1,559,997. No cost extension. NIH NIDA – “Opiate induced SIV-Neuropathogenesis: Role of miRNA-29b in the Periphery-CNS Crosstalk.” February 1, 2013 – January 31, 2018. Principal Investigator: S. Buch, Co-Investigator: P.D. Cheney (10% effort). Direct costs: $1,903,241, total costs: $2,298,771. KUMC subcontract: year 2 direct costs: $215,068, Total costs: $315,990.

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NIH-NICHD – “Kansas Intellectual and Developmental Disabilities Research Center.” June 1, 2011 – July 31, 2016. Theme Leader, J. Colombo. Total costs July 1, 2011 – June 30, 2012: $1,369,872. V.M. Chennathukuzhi: KU Endowment Startup funds – 2009-current. NIH/NICHD – “Dissecting the functional role of miRNAs in decidualization. ” Principal Investigator: W. Nothnick, Co-Investigator: VM Chennathukuzhi. 2013 – 2015. Annual Direct Costs: $125,000. NIH/NICHD – “The role of REST in the pathogenesis of uterine fibroids” July 2013 – June 2018. Principal Investigator: V.M. Chennathukuzhi. Annual Direct Costs: $238,042. NIH/NICHD – “Inhibitors of Na,K-ATPase alpha4 as male contraveptives.” 2014-2019. Annual Direct Costs: $182,000. L.K. Christenson: NIH-NICHD – “MicroRNA Regulation of Ovarian Function.” July 1, 2010 – June 30, 2015. Principal Investigator: L.K. Christenson. Annual Direct Costs: $266.636. KU Cancer Center – “Exosomes and their non-coding RNA profiles in Barrett’s Esophagus. January 9, 2014 – December 30, 2015. Principal Investigator: A. Bansal, Co-Investigator: L.K. Christenson. $35,000. NASA – “Female reproductive health: Space flight induced ovarian and estrogen signaling dysfunction, adaptation, and recovery.” November 1, 2014 – October 31, 2017. Annual Direct Costs: $178,678. NICHD – “Exosome/ microvesicle regulation of oocyte development competence.” December 15, 2014 – November 30, 2016. Annual Direct Costs: $150,000. KINBRE – “MicroRNA Based Nanotherapeutics for Barrett’s Neoplasia.” May 1, 2015 – april 30, 2016. Annual Direct Costs: $50,000. Lalor Foundation – “The role of CD81 in follicular exosome function.” June 1, 2015 – May 31, 2016. Principal Investigator: . Annual Direct Costs: $50,000. COBRE – “Molecular Regulation of Cell Development and Differentiation.” September 1, 2012 – June 30, 2017. S.J. Enna: Elsevier – Editorial Office: Biochemical Pharmacology and Pharmacology and Therapeutics. 2004 – 2019. Annual Direct Costs: $140,000. International Union of Basic and Clinical Pharmacology – Society Office. 2006-2018. $52,000.

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NICHHD – “Kansas University Training Program in Neurological and Rehabilitiation.” Principal Investigator: R.J. Nudo. Associate Director: S.J. Enna. May 2014 – April 2019. Annual Direct Costs: $266,000. S. Frost: NIH/NINDS – “Reorganization of motor cortex following brain injury.” February 1, 2008 – January 31, 2015. Principal Investigator: RJ Nudo, Co-Investigator: S. Frost. Annual Direct Costs: $3,105,385. P.C. Geiger: NIA/NIAMS – “Targeting stress-mediated pathways in the treatment of muscle insulin resistance.” July 1, 2010 – June 30, 2016. Principal Investigator: P.C. Geiger. Annual Direct Costs: $155,000. Liver Cobre Pilot Award – “Heat shock proteins and mitochondria in the prevention of non-alcoholic fatty liver disease.” April 1, 2015 – June 30, 2015. Annual Direct Costs: $50,000. KINBRE Pilot Award – “Targeting estrogen receptor alpha in the prevention of obesity and type 2 diabetes.” April 1, 2015 – March 31, 2015. Annual Direct Costs: $40,000. IRHRM Pilot Award – “The role of estrogen receptor alpha in control of energy balance and glucose homeostatis.” October 1, 2014 – September 30, 2015. Annual Direct Costs: $10,000. N.C. Gonzalez: NIH – “Targeting stress-mediated pathways in the treatment of muscle insulin resistance.” August 15, 2010 – May 31, 2015. Principal Investigator: P.C. Geiger, Co-Investigator: N.C. Gonzalez. Total costs: $148,967. American Heart Association – “Hypoxia adaptation by a unique mechanism of reprogramming mitochondrial metabolism” July 1, 2013 – June 30, 2015. Principal Investigator: P. Kasturi. Co-Investigator: N.C. Gonzalez. Total costs: $71,500. L.L. Heckert: Marion M. Osborn Endowment NIH – “Molecular Regulation of Cell Development and Differentiation.” September 1, 2012- June 30, 2017. Principal Investigator: D. Abrahamson. Co-Investigators: G. Andrews and M. Soares. Co-Director of Core B: L.L. Heckert. Direct costs: $1,500,000/yr RI – “In vivo Function of a 3’ Distal Regulatory Element of Fshr.” February 3, 2015 – February 29, 2016. Annual Direct Costs: $20,000. RI – “Travel award to NA Testis Workshop.” April 2015. $326.

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T.R. Kumar: NIH/NIA – “The Role of Rest in the Pathogenesis of Uterine Fibroids.” August 12, 2013 – April 30, 2018. Co-Investigator: T.R. Kumar. Annual Direct Costs: $227,306. NCI/NIH – “Chemoprevention of pituitary gonadotrope tumors.” 2013 – 2017. Principal Investigator: T.R. Kumar. Total costs: $207,500/yr. NCI/NIH – “Dysregulation of FSH in Obesity: Functional and Statistical Analysis.” August 28, 2015 – May 31, 2020. Co-Investigator: T.R. Kumar. Annual Direct Costs: $242,440. M.A. Larson: Center of Biomedical Research Excellence (COBRE) Institutional Development Award (IDeA), National Center for Research Resources, NIH – “Molecular regulation of cell development and differentiation.” September 1, 2012 – June 30, 2017. Principal Investigator: D. Abrahamson Core B – “Transgenic Facility.” Principal Investigator: M.A. Larson. Total direct costs for entire project period: $617,085. Kansas-Idea Network of Biomedical Research Excellence (K-INBRE) K-INBRE Institutional Core Facility Support Proposal – “Completion of a Dedicated Surgical Suite for Embryo Transfer Surgeries with Refined Anethesia Delivery Apparatus” May 1, 2014 – April 30, 2015. Principal Investigator: M.A. Larson. Direct costs for equipment: $10,000 S.M. LeVine: ApoPharma Inc. – “Iron Chelation in Experimental Autoimmune Encephalomyelitis” March 2013 – June 2015. Annual Direct Costs: $69,171. COBRE-Novel Approaches for the Control of Microbial Pathogens – “Genetic Modifiers of Sepsis” August 1, 2014 – Junly 31, 2015. Annual Direct Costs: $55,000. W.B. Nothnick: NIH – “The role of miR-451 in endometriosis pathophysiology and treatment.” February 1, 2014 – January 31, 2015. Principal Investigator: W.B. Nothnick. Total direct costs $303,941. Indirect costs: $86,351. Frontiers Pilot and Collaborative Studies Funding Program and the KUMC Research Institute Clinical Pilot Program – “Dissecting the functional role and regulations of megalin in human endometriosis.” February 1, 2015 – January 31, 2016. Principal Investigator: W.B. Nothnick. Annual Direct Costs: $30,000. NIH – “The role of REST in the pathogenesis of uterine fibroids.” May 1, 2015 – April 30, 2016. Principal Investigator: W.B. Nothnick, Co-Investigator: V. Chennathukuzhi. Annual Direct Costs: $227,306. Indirect costs $99,561. R.J. Nudo: NIH/NINDS – “Reorganization of Motor Cortex Following Brain Injury.” 2012-2016. Principal Investigator: R.J. Nudo. Annual Direct Costs per year: $485,851.

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NIH/NICHD – “Kansas Training Grant in Neurological and Rehabilitation Sciences.” July 1, 2014 – April 30, 2019. Program Director: R.J. Nudo. Principal Investigator: R. Nudo. Annual Direct Costs per year: $237,223. Department of Defense – “A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury.” September 1, 2010 – August 31, 2014. Principal Investigator: R.J. Nudo. Annual Direct Costs per year: $125,000. RDD Foundation – “Electronic Aids to Bridge Damaged Spinal Cord Pathways.” 2011-2016. Total Cost: $1,867,000. NIH– “Examining vascular regulation following acute stroke.” 2011-2016. Total Costs: $110,000. P. Ramamoorthy: University of Kansas Cancer Center Pilot Project – “Heat shock protein, hypoxia and cancer stem cells in colon cancer.” June 1, 2012 – December 31, 2014. Principal Investigator: P Ramamoorthy, Mentor: S. Anant. $35,000. University of Kansa Cancer Center PO1 Pilot Project – “RNA binding proteins on colorectal cancer.” 2013 – 2014. Co-Investigator: P. Ramamoorthy. $50,000. KUCC – “Glioblastoma in a Dish (GiD)- A novel approach for precision Medicine.” 2015 – 2016. Total Direct Costs: $35,000. P.G. Smith:NIH – “Identifying therapeutic targets for vulvodynia.” July 1, 2012 – June 30, 2017. Principal Investigator: P. Smith. Total Costs: $2,348,000. NIH – Institutional Clinical and Translational Science Award. June 1, 2011 – February 29, 2016. Total Costs: $3,090,358. Kansas University Endowment Association – “Spinal Cord Injury Repair Program.” April 15, 2011 – April 14, 2016. Total Costs: $1,531,000. University of Kansas Center for Research – Kansas Intellectual & Developmental Disabilities Research Center (KIDDRC). September 26, 2011 – June 30, 2016. Annual Direct Costs: $408,000. NIH – “Creation and characterization of models of a BLHLB9 developmental disorder.” June 1, 2015 – May 31, 2017. Annual Direct Costs: $270,000. Merck, Sharpe & Dohme – “Investigations of novel antagonists on sensory innervation and inflammatory pain.” December 17, 2014 – December 16, 2015. Annual Direct Costs: $200,000.

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J.A. Stanford: CMH Research Agreement Children’s Mercy Hospital – “Preclinical studies of bilirubin encephalopathy.” June 1, 2013 – May 31, 2016. Contract Principal Investigator: J.A. Stanford. Annual Direct Costs: $100,000. NIH/NCRR – “Translating neuromuscular effects of targeted isometric strength training.” May 1, 2014 – April 30, 2015. Principal Investigator: D. Wright. Translational Partner: J.A. Stanford. Total costs: $50,000. D. Subramaniam: KUCC Pilot Project – “Targeting Notch signaling by Tandutinib in colon cancer.” June 1, 2013 – September 31, 2014. Principal Investigator: D. Subramaniam. Annual Direct Costs: $35,000. KUCC Pilot Project – “Cancer Associated fibroblasts modulating activity of DCLK1 positive cells.” June 1, 2015 – May 30, 2016. Principal Investigator: D. Subramaniam. Annual Direct Costs: $35,000. J.S. Tash: NIH – “H2-Gamendazole analogues as reversible non-hormonal male contraceptive agents.” September 01, 2012 – June 31, 2017. NIH – “Cell-cycle regulatory kinases as targets for male contraceptive drug development.” April 1, 2014 – March 31, 2019. NASA – “Space flight-altered motility activation and fertility-dependent responses in sperm from sea urchin and rodents.” August 1, 2013 – July 31, 2015. NASA – “Female reproductive health: Space flight induced ovarian & estrogen signaling dysfunction, adaptation, and recovery.” November 1,2014 – October 31, 2017. J. Thyfault: NIH– “Aerobic fitness, mitochondrial dysfunction, and fatty liver disease.” April 1, 2011 – March 31, 2016. Principal Investigator: J. Thyfault. Direct costs: $1,462,508. Veteran Affairs Merit Review – “Mitochondrial mitophagy in the development and treatment of NAFLD.” October 1, 2014 – September 31, 2018. Principal Investigator: J. Thyfault. Annual Direct Costs: $961,328. American Heart Association Post-Doctoral Student Research Award – “PGC-1a regulates TAG secretion.” July 1, 2014 – June 30, 2016. Principal Investigator: E.M. Morris, Mentor: J. Thyfault. Annual Direct Costs: $98,476. S. Umar: NCI – “Epigenetics and Infection-induced EMT of Colonic Crypts- Target for Chemoprevention.” December 1, 2014 – November 30, 2019. Annual Direct Costs: $263,084. NCI – “Bitter Melon Component and Colon Cancer Prevention.” September 1, 2014 –August 31, 2019. Annual Direct Costs: $360,735.

49

M.W. Wolfe: NIH – “Stem cells and epigenetics of trophoblast lineage development.” July 2014 – June 2019. Annual Direct Costs: $733,408.

50

51

ACTIVITIES OF THE FACULTY

David F. Albertini, Ph.D., Professor Physiology and developmental biology of mammalian reproduction, particularly in oogenesis, and the translation of basic science on oocyte and embryo quality to human assisted reproductive technologies. Meetings Attended:

June 30, 2014 – “The connection between maternal health, oocyte quality, and offspring produced by human ARTs,” IBSA Symposium on the future of human ARTs. European Society for Human Reproduction and Embryology (ESHRE), Munich Germany

September 13, 2014 – “Is aneuploidy so bad for human embryos afterall?” Aneuploidy Symposium, Canadian Fertility and Andrology Society, Quebec City, Canada

October 9 – 12, 2014 – “New insights into the biology of the ovarian reserve,” and “Revisiting the mechanism of LH-induced oocyte maturation: more questions than answers.” Tecnobios Procreazione Symposium, Rome Italy

October 21, 2014 – “Gateways to success: the sperms’ perspective for finding and penetrating the egg,” Society for Male Reproduction and Urology Symposium, American Society for Reproductive Medicine annual meeting; Honolulu, Hawaii

Committee Activities: Departmental

Member, Graduate Student Committee Member Danny Miller, M.D./Ph.D. Swathi Iyer, Ph.D.

National Member, Worcester Polytechnic Institute Member, International Ovarian Club Board Editorial and Grant Reviews:

Editor-in-Chief, Journal of Assisted Reproduction and Genetics Associate Editor, Zygote

Section Editor, “Gametes and Embryos” in 4th Edition Knobil and Neill’s Physiology of Reproduction, Editors-in-Chief Tony M. Plant and Anthony J. Zeleznik

Ad hoc Reviewer, Science Ad hoc Reviewer, Nature Ad hoc Reviewer, Nature Medicine Ad hoc Reviewer, PNAS Ad hoc Reviewer, Human Reproduction

52

Dr. Albertini (continued) Editorial and Grant Reviews (continued)

Ad hoc Reviewer, Biology of Reproduction Ad hoc Reviewer, PLoS One Grant Reviewer, Maryland State Stem Cell Grant review Committee Grant Reviewer, MRC Grant Reviews (UK) Seminars Presented:

November 14, 2014 – “Genetic instability in human embryos: origins and consequences,” Ovarian Club IV Meeting, Paris, France

November 25, 2014 – “Ovarian Physiology in 2014-A changing landscape,” Grand Rounds the Center for Human Reproduction, New York, NY

January 16, 2015 – “The oocyte as a unique cell.” International Society for Fertility Preservation Symposium, Brussels, Belgium

February 15, 2015 – “Building an ovary is a complicated matter.” ESHRE Workshop on Development of the Mammalian Gonad, Muenster, Germany

Teaching Activities: CORE 830 – Fertilization 1 hour lecture PHSL 834 – Reproductive Physiology 5 – 2 hour lectures IGBPS – Cell Cycle 3 – 2 hour lectures Other Activities: Attendee, Ovarian Club Organizing Committee (annual meeting) Attendee, International Society for Fertility Preservation (annual meeting)

53

Shrikant Anant, Ph.D., Professor; Tom and Teresa Walsh Professor of Cancer

Prevention; Eminent Scholar, Kansas Bioscience Authority; Associate Director of

Prevention and Cancer Control

I am currently the Tom and Teresa Walsh Professor of Cancer Prevention and the Kansas Mason Professor of Cancer Research in the Department of Molecular and Integrative Physiology at the University of Kansas Medical Center. I am an RNA biologist with interests in understanding the mechanisms that regulate gene expression at the posttranscriptional levels of mRNA stability and translation during tumorigenesis. My laboratory has been a leader in the identification of novel RNA binding protein protooncogenes and tumor suppressors. In addition, we have been leading the efforts on determining the mechanism by which natural and synthetic compounds affect cell signaling pathways in gastrointestinal cancer cells. My lab members primarily focus their work on gastrointestinal cancers. Specific areas of research include: a) Regulation of gene expression at the levels of mRNA stability and translation, b) Cancer Stem Cells, and c) mechanisms of chemoprevention by dietary factors and its novel derivatives. Meetings Attended:

January 2015 – 3rd International Conference on Herbal and Synthetic Drug Studies, Pune, India

March 2015 The Second Shanthi Sitaraman Intestinal Pathobiology Symposium, Georgia State University, the Petit Science Center February 2014 – present, Biomimetic Tissue Engineered Workshop, Washington, DC

January 2014 – Keynote Speaker, University of Madras, India Symposium on Emerging Diseases (February 2015Invited Speaker, Indian Science Congress, Mumbai, India

December 2014 – Invited Speaker, Massachusetts General Hospital, Gastroenterology

October 2014 – Invited Speaker, Annual Symposium of Texas A&M Digestive Disease Research Center, College Station

September 2014 – Invited Speaker, Biochemistry and Molecular Biology, University of Nebraska, Department of Biochemistry and Molecular Biology

August 2014 – Keynote Speaker, Prof. KJ Endowment Lecture Series, Vellore Institute of Technology, India

July 2014 – Invited Speaker, Department of Genetics, Sri Ramachandra Medical College, Chennai, India

July 2014 – Invited Speaker, Department of Endocrinology, University of Madras, India

54

Dr. Anant (continued) Committee Activities: Departmental Member, Promotion and Tenure Committee

Graduate Student Committee Member Kelsey Hampton, M.S. Swathi Iyer, M.S. Asona Lui, M.D./Ph.D. Kishore Polireddy, M.S. Lili Pan, M.S.

KUMC Member, Faculty Position Search Committee – Cancer Center

Member, Faculty Position Search Committee – Cancer Biology Member, Genomic Facility Advisory Committee Member, KUCC Scientific and Clinical Research Sub-Committee National Member, Cancer Research UK Programee – Norbury Peer Review Chair, VA Gastroenterology Review Committee Editorials and Grant Reviews:

Member, NIH Chemo/Dietary Prevention (CDP) Study Section Chair, Chemoprevention SEP Panel Member, NCI SPORE review panels (2012 Oct- Discussion Leader, GI SPORE) Member, Fellowships Panel, Complementary and Alternative Medicine Chair, NCCAM Program Projects Study Section Chair, VA Gastroenterology Merit Review Study Section (2014-2016) Editorial Board Member, BMC Physiology (2011-present) Editorial Board Member, Cancer Research (2013-present) Editorial Board Member, Clinical Medicine: Gastroenterology (2007-present) Editorial Board Member, ECAM (2006-present) Editorial Board Member, Molecular Carcinogenesis (2014-present) Editorial Board Member, European Journal of Clinical Medicine (2010-present) Editorial Board Member, Immuno Gastroenterology (2011-present) Editorial Board Member, International Journal of Cancer (2008-present) Editorial Board Member, International Journal of Oncology (2008-present) Editorial Board Member, Translational Gastrointestinal Cancer (2011-present) Ad hoc Reviewer, EMBO Journal Ad hoc Reviewer, PNAS USA Ad hoc Reviewer, Gastroenterology Ad hoc Reviewer, Molecular and Cellular Biology Ad hoc Reviewer, Journal of Lipid Research Ad hoc Reviewer, Metabolism Ad hoc Reviewer, American Journal of Physiology-GI Ad hoc Reviewer, Digestive Diseases and Science Ad hoc Reviewer, Gut

55

Dr. Anant (continued) Editorial and Grant Reviews (continued)

Ad hoc Reviewer, AJP GI and Liver Ad hoc Reviewer, Journal of Biological Chemistry Ad hoc Reviewer, Cancer Research Ad hoc Reviewer, Human Heredity Ad hoc Reviewer, Journal of Cellular Biochemistry

Teaching Activities: Carcinogenesis and Cancer Biology course 1 lecture Trainees: Afreen Sayed, Graduate Student

Zainab Afsal, Rotation student Julia Balmaceda- Summer Student Parasarathy Rangarajan, Post-doctoral Fellow (Effect on Cyclopirox on Bladder

Cancer) Deep Kwatra, Post-doctoral Fellow (Bitter melon and its component Charantin on

colon cancer therapy) Gaurav FNU, Post-doctoral Fellow (Honokiol effect on Melonama) Prasad Dandawate- Postdoctoral Fellow (Jak2 and Stat3signling pathway on

pancreatic cancer) Satheesh K. Sainathan- Senior Scientist (Prolatin and its signaling pathways) Dr. Pablo Angulo, DO, Fellow in Children Mercy Hospital (Osteosarcoma –

therapy) Sivapriya Ponnurangam, Research Associate David Standing, Research Technician Dharmalingam Subramaniam, Research Assistant Professor- Molecular &

Integrative Physiology Satish Ramalingam, Research Assistant Professor - Molecular & Integrative

Physiology Prabhu Ramamoorthy, Research Assistant Professor - Molecular & Integrative

Physiology Dr. Aravind Sugmar, MD, Assistant Professor- Internal Medicine (Effect of Gedunin

and its analog on pancreatic cancer) Dr. Seth Septer, MD, Assistant Professor -Children Mercy Hospital (FAP, Colon

Cancer Prevention and therapy) Dr. Kathrine Chastain, Assistant Professor- Children Mercy Hospital (Sarcoma in a

Dish) Dr. Joshua Mammen, M.D./Ph.D., Associate Professor of Surgery and Molecular &

Integrative Physiology (Effect of Honokiol on Melanoma) Dr. Animesh Dhar, Associate Professor of Cancer Biology (Histone demethylases

in Cancer) Dr. Sufi Thomas, PhD – Associate Professor Otolaryngology and Cancer Biology

56

Dr. Anant (continued) Trainees (continued)

Dr. Ramesh Balusu, PhD – Assistant Professor, Hematologic Malignancies and Cellular Therapeutics

Dr. Rekha Rao Manepalli, PhD – Assistant Professor, Hematologic Malignancies and Cellular Therapeutics

Other Activities: Thomas O Sullivan Foundation- Golf Tournament; Colon cancer awareness

Rod Rogers Memorial Golf Tournament- Golf Tournament; Pancreatic cancer awareness

57

Andrei B. Belousov, Ph.D., Associate Professor My interests include (1) the cellular and molecular mechanisms for regulation of electrical synapses (gap junctions) during development and neuronal injury and (2) the role of gap junctions in neuronal death/survival mechanisms during development and injury. Meetings Attended:

March 28- April 1, 2015- International Gap Junction Conference. Valparaiso, Chile

Committee Activities: Departmental

Member, Graduate Student Advisory Committee KUMC Physiology Department Representative, KUMC Faculty Council

Member, Interdisciplinary Graduate Program in Biomedical Sciences (IGPBS) Admission Committee

Editorial and Grant Reviews: Ad hoc Reviewer, Nature Reviews Neuroscience Ad hoc Reviewer, Frontiers in Cellular Neuroscience Ad hoc Reviewer, International Journal of Molecular Sciences Ad hoc Reviewer, Behavioral Brain Research Ad hoc Reviewer, FEBS Letters (2 papers) Ad hoc Reviewer, Neuroscience Ad hoc Reviewer, African Journal of Biotechnology Ad hoc Reviewer, Translational Neuroscience Ad hoc Reviewer, The open Neuroscience Journal Editorial Board Member, the Open Neuroscience Journal (ON), Bentham

Science Publishers Served on as institutional reviewer for The Research Foundation Flanders

(Fonds Wetenschappelijk Onderzoek-Vlaanderen, FWO), which is an independent funding agency that supports fundamental research in Belgium.

Academic Honors:

I gave an invited lecture at the International Gap Junction Conference, Valparaiso, Chile, March 28-Apri 1, 2015.

Teaching Activities: PHSL 842 – Comprehensive Human Physiology 9 – 2 hour lectures PTRS 863 – Pathobiology of Human Function 1 – 2 hour lecture GSMC 853 – Cellular Structure

58

Dr. Belousov (continued) Training Activities (continued)

2 – 2 hour lectures 1 – 2 hour seminar T32 Summer Journal Club 1– 2 hour discussion Trainees: Janna V. Belousova, Senior Research Assistant

59

V. Gustavo Blanco, M.D., Ph.D., Professor & Interim Chair Our laboratory studies the role of ion-transport proteins of the plasma membrane in cell function. Research is focused on the Na, K-ATPase, a plasma membrane enzyme system that uses the energy from ATP to maintain high intracellular K+ and low intracellular Na+ concentrations in the cell, which are essential for cell function. The Na,K-ATPase comprises a group of isozymes, each characterized by unique enzymatic properties and a cell-dependent and developmentally regulated pattern of expression. Our research is focused on two main projects. 1. Studies on Na,K-ATPase alpha4. Alpha4 is an isoform of the catalytic subunit of the Na,K-ATPase that is selectively expressed in spermatozoa. We have found that alpha4 has functional properties that are different from those of the other Na,K-ATPase isoforms. Alpha4 is expressed in the mid-piece of the sperm flagellum, and is important for sperm motility and fertility. A variety of molecular, cell biology and genetics approaches are being used to study the regulation, activity and mechanisms of action of alpha4 in sperm physiology. Also, we are searching for compounds that will specifically inhibit alpha4, with the idea of using them as male contraceptive agents. These studies will help understand the importance of ion transport in male gamete fertility and contraception. 2. Studies on the role of the Na,K-ATPase in autosomal dominant polycystic kidney disease (ADPKD). We have found that renal epithelial cells from patients with ADPKD and various mouse models of ADPKD, have Na,K-ATPase with an abnormally high affinity for ouabain, a hormone released by the adrenal glands. We have demonstrated that ouabain stimulates cyst formation and growth by ADPKD cells and kidneys. This places ouabain as an agent that can exacerbate the progression of ADPKD. Currently, using human kidney ADPKD cells and different mouse models of ADPKD, we are investigating the mechanisms by which ouabain affects cyst formation and progression in the disease and how to interfere with these effects. Our goal is to find pharmacological approaches to slow ADPKD cystogenesis. Meetings Attended:

August-September 2014 – Chair of a session entitled: ATPases. Physiology, Medicine and Therapy. 14th International ATPase Conference. Lunteren, The Netherlands

October 2014 – Gladis Sanchez, Shameen Sultana Syeda, Kwon Ho Hong, Gunda Georg and Gustavo Blanco. Cardenolide inhibition of the sperm-specific Na,K-ATPase α4 for male contraception.

October 2014 – Blanco G. Ouabain-induced and Na,K-ATPase-mediated effects in autosomal dominant polycystic kidney disease. Sullivan Seminar Series, Kidney Institute

October 2014 – Blanco G. Na,K-ATPase alpha4 inhibitors as male contraceptives. U01 Meeting, KUMC

April 2015 – Blanco G. Na,K-ATPase α4 isoform as a target for male contraception. American Society of Andrology Meeting, Salt Lake City

60

Dr. Blanco (continued) Committee Activities: Departmental

Member, Ph.D. Thesis Committee for Michelle McWilliams (Dept. Physiology)

Member, Ph.D. Thesis Committee for Archana Raman (Dept. Physiology) Member, Ph.D. Thesis Committee for Pei-Lei (Dept. Physiology) Member, Ph.D. Thesis Committee for Wei-Ting (Dept. Physiology) Member, Ph.D. Thesis Committee for Wen Zhao (Dept. Pharmacology) Member, Ph.D. Thesis Committee for Kelly Boxberger (Dept. Pharmacology) Member, Ph.D. Thesis Committee for Yuchen Zhang (Dept.

Pharmacology) KUMC Member, Ph.D. Thesis Committee for Zahraa Alali (Dept.

Physiology) KUMC Member, Department P&T Committee

Member, Physiology Department Advisory Finance Committee Member, Comprehensive exam Committees for graduate students

KUMC Director, Developmental Research Project Core of the K-INBRE.

Member, Wescoe Society, serving as a mentor for medical students. Member, MD/Ph.D. Admission Committee Program, including interviewing

students Member, Kidney Institute Executive Board Member, LCME visit for accreditation committee of KUMC Member, University Biotechnology Sequencing Facility Member, Organization of the Greenwald Symposium in Reproduction Editorial and Grant Reviews:

Editorial Board Member, American Journal of Physiology, Metabolism and Endocrinology Section

Editorial Board Member, Journal of Assisted Reproduction and Genetics Reviewer, Andrology

Reviewer, Agencia Nacional de Investigacion e Innovacion, Uruguay 2014 Reviewer, National Agency for Scientific Promotion and Technology, Argentina Reviewer, German-Israeli Foundation for Scientific Research and Development

Charter Member, NIH CMIR Study Section Member, Selection Awards Committee for the American Society of Andrology

61

Dr. Blanco (continued) Seminars Presented:

December 2014 – “Na, K-ATPase-mediated effects in autosomal dominant polycystic kidney disease.” Marshall University, Huntington, WV

January 2015 – Radbound University Medical Center, Nijmegen, The Netherlands

May 2015 – “Frontiers in Reproduction.” Marine Biological Laboratories, Woods Hole, MA

Academic Honors:

Students Voice Award for Excellence in Teaching (2014-2015), University of Kansas Medical Center

Teaching Activities: Renal Physiology, CORE 825 – Renal Endocrine System, Medical Physiology 11 hours lecture 4 hours Interactive clinical cases in renal physiology 2 hours review for renal physiology for Board preparation 4 hours small group facilitation

Integration and Consolidation CORE 860 – Renal Physiology for Medical Students 1 hour Lecture

Renal Physiology. Board review, Step Prep 1 contact hour.

IGPBS 853 – Cell membrane structure and transport systems of the plasma membrane. 6 hours lecture. Advanced Topics in Renal Physiology. Kidney Institute Course.

4 contact hours Comprehensive Human Physiology, PHSL 842 – Graduate student course.

6 contact hours. Pre-Med college students from KU

2 contact hour. Wescoe Society Mentor 1 hour group session

Ion motive ATPases – Radbound University Medical Center, Nijmegen, The Netherlands

Frontiers in Reproduction – Marine Biological Laboratories, Woods Hole, MA Other Activities: Thesis Dissertation committees for the following students: Carina Henriksen, Aarhus University, Aarhus, Denmark Karl Weigand, Radbound University, Nijmegen, The Netherlands

62

Dr. Blanco (continued) Trainees:

Gladis Sanchez, Research Associate. Project title: Na,K-ATPase alpha4 as a target for male contraception.

Jeff McDermott, Research Associate. Project title: Physiology of Na,K-ATPase alpha4.

Jessica Venugopal, Graduate Student. Project title: Ouabain induced and Na,K-ATPase mediated effects in polycystic

kidney disease

63

Paul D. Cheney, Ph.D., Professor Neurophysiological techniques are used to investigate the functional contribution of neurons in the cerebral cortex and brainstem to the control of voluntary movement. The spike (action potential) activity of single neurons is recorded in awake monkeys trained to perform various movement tasks. Computerized analysis techniques are used to reveal the functional contribution of a neuron or localized groups of neurons to movement. In another project, SIV infection in monkeys is used as model of neuro-AIDS. This model is used to investigate interactions between SIV infection and drugs of abuse using neurobehavioral, neurophysiological, and neuroanatomical methods. Meetings Attended:

November 15-19, 2014 – 44th Annual Meeting of the Society for Neuroscience,

Washington, DC

Committee Activities: Departmental Comprehensive Exam Committees: Dissertation Advisor, MD/PhD Committee for Naomi Butler Tjaden

Member, Ph.D. Committee for Anaria Barnds (Biomedical Engineering)

School of Medicine Member, Internal Advisory Committee, NIH Neuroscience Rehabilitation Training Grant, Dr. Nudo, PI. Member, Mentoring Awards Review Committee

KUMC Member, Institute for Neurological Disorders Executive Committee

Co-director, Neuromuscular and Movement Disorders Division of the Institute for Neurological Disorders

Dissertation Co-advisor, Sommer Amudson – Ph.D. Bioengineering Research Mentor, Hesham Soloman, M.D. – Senior neurosurgical resident

KUMC-KU Lawrence Member, KU Bioengineering Advisory Committee

Member, KIDDRC Internal Scientific Advisory Committee KIDDRC Theme leader, Neurobiology of Mental Retardation and

Developmental Disabilities National

Member of the UMKC School of Medicine Endowed Chair Review Committee for the review of Dr. John Wang, Professor of Anesthesiology, January 22nd, 2015

Editorials and Grant Reviews: Ad hoc Reviewer, J. Neurophysiology Ad hoc Reviewer, J. Neuroscience

Ad hoc Reviewer, Experimental Brain Research Ad hoc Reviewer, Brain

Ad hoc Reviewer, Cerebral Cortex

64

Dr. Cheney (continued) Editorials and Grant Review (continued)

Ad hoc Reviewer, Brain Stimulation Ad hoc Reviewer, Neuroscience Letters Grant Reviewer, KUMC, Woodyard Fellowship Applications, Institute for

Neurological Disorders Grant Reviewer, KUMC Biomedical Research Training Program

Grant Reviewer, Frontiers Clinical Pilot and Collaborative Studies Funding Program and KUMC Research Institute Internal Clinical Pilot Research Grant and Lied Basic Science Grant Programs

Grant Reviewer, Letters of intent for KIDDRC U54 research projects

Teaching Activities:

PHSL 846 – Advanced Neuroscience Summer 2015, 3 students 6 lecture hours REHS 962 – Advanced Rehabilitation Science Fall 2014, 4 students 2 hours lecture Mechanical Engineering, Biomechanics (Dr. Carl Luchies-Director) Fall 2014, 30 students 2 hours lecture PTRS 882- Pathobiology of Human Function Spring 2015, 6 students 2 hours lecture Dissertation co-advisor – Sommer Amundson, Ph.D. Bioengineering student Research Mentor – Hesham Soloman, M.D. Senior neurosurgical resident

65

Vargheese M. Chennathukuzhi, Ph.D., Assistant Professor My research interests include uterine fibroids, fertility and contraception. Uterine fibroids are the most common tumors of the female reproductive tract and are the predominant indication for hysterectomies in the US. Yet, there is no approved drug to treat uterine fibroids chronically. Our laboratory is currently trying to understand the regulation and function of GPR10, a G protein-coupled receptor aberrantly expressed in uterine fibroids. Activation of GPR10 by its cognate ligand promotes cell proliferation, specifically in cultured primary leiomyoma (fibroid) cells. We have generated transgenic mice overexpressing GPR10 in the myometrium in order to understand its role in the pathogenesis of fibroids. Transgenic mice expressing hGPR10 in the myometrium develop uterine fibroids that are phenotypically identical to the human disease. We plan to use this preclinical model for the development of small molecule modulators of GPR10 as treatment for fibroids. In addition, we have identified the molecular machinery that regulates aberrant expression of GPR10 in uterine fibroids. We are currently developing loss of function models for REST, the transcriptional repressor of GPR10, and for PRICKLE 1, the gene that regulates REST.

Our laboratory is also interested in molecules that regulate sperm function and male fertility. We are studying functional regulation of the sperm specific sodium-proton exchanger (sNHE) in expression systems that utilize chimeric channels. Committee Activities: Departmental Member, Thesis Committee, Zahraa Alali Member, Thesis Committee, Younshim Park Member, Thesis Committee, Sara Pearson Member, Thesis Committee Wei-Ting Hung Member, Thesis Committee Safder Saieed Member, Thesis Committee Ashley Ward Member, Finance Committee Member, GSAC Co-coordinator, Physiology Seminar Series KUMC Member, D3ET (Drug Discovery, Delivery and Experimental

Therapeutics), IAMI

Editorial and Grant Reviews: Reviewer, Human Reproduction Reviewer, Biology of Reproduction Reviewer, Molecular Reproduction and Development Reviewer, Developmental Biology Member, Special Emphasis Panel/Scientific Review Group 2015/10 ZRG1 EMNR-A (02) M

Member, Special Emphasis Panel/Scientific Review Group ZRG1 EMNR D2015 (02)

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Dr. Chennathukuzhi (continued) Seminars Presented:

November 14, 2014 – “REST and the pathogenesis of uterine leiomyomas.” University of Missouri, Columbia

December 11, 2014 – “The role of REST in the pathogenesis of uterine fibroids.” Anatomy and Cell Biology, KUMC

Teaching Activities: PHSL 834 – Reproductive Physiology Course Co-Director 9 hours

IGPBS 851 – Genetic Switches-Gene 6 hours

Trainees:

Faezeh Koohestani, Ph.D. (Postdoctoral Fellow): The Role of REST in the pathogenesis of uterine fibroids

Michelle McWilliams (Graduate Student): Estrogenic regulation of PRICKLE1 and its effect on REST in uterine fibroids

Mina Farahbakhsh (M.D./Ph.D. Graduate Student): Role of ADAM12 and other REST target genes in uterine fibroids

Sornakala Ganeshkumar (Research Assistant) Kavya Shivashankar (Summer Intern, June – Aug 2014, Undergraduate Student,

Columbia, NY. Ganesh Aruna (Summer Intern, June – Aug 2015, High School Senior):

Regulation of PRICKLE1 in Alzheimer’s disease

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Lane K. Christenson, Ph.D., Associate Professor Fertility control is a major health concern for premenopausal women. Research in my laboratory focuses on understanding the terminal events involved in follicular development, ovulation and luteal tissue formation. The studies have direct implications in development of a fertile healthy oocyte, contraception and disease conditions such as polycystic ovarian syndrome and ovarian cancer. Current studies focus on understanding the role microRNA post-transcriptional gene regulation plays in the ovulatory process. The laboratory is also working to understand what role extracellular vesicles (exosomes and microvesicles) play in ovarian function (oocyte maturation, granulosa cell function) and in ovarian cancer. These studies use the latest state of the art technologies, including next-gen-sequencing, nanoparticle analysis in addition to standard molecular and biochemical techniques. The laboratory also uses a comparative approach using human, bovine and murine cells and animal studies in both cows and mice to gain further insights into the reproductive biology of the ovary. Committee Activities: Departmental Co-Director, Graduate Student – GSAC Member, Departmental Finance Committee

Graduate Student Committee Member: Erin Farmer (Hays) (Physiology)-M.S. Advisory Committee Chair

Jennifer Crow (Pathology) - Ph.D. Advisory & Dissertation Member

Stacey Keller (Biostatistics) – M.S. Advisory Committee Member Li Chen (Physiology) –Ph.D. Advisory Committee Member Bryce Warren (Anatomy) – Ph.D. Advisory Committee Member Hanan Elsarraj (Pathology) – Ph.D. Advisory Committee Member

KUMC Member, Advisory Committee for the Microarray Facility Member, Mass Spectrometry Oversight Committee

National Director on SSR Board, Society for Study of Reproduction Program Committee Co-Program Chair, 2016 SSR Meeting Section Director, Frontiers in Reproduction Course at Marine Biol. Laboratory

Editorial and Grant Reviews:

Ad hoc Reviewer, Cell and Tissue Research Ad hoc Reviewer, Endocrinology Ad hoc Reviewer, Reproduction Ad hoc Reviewer, FEBS Letters

Ad hoc Reviewer, Plos Genetics Ad hoc Reviewer, Plos One Ad hoc Reviewer, Mutation Research Reviews

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Dr. Christenson (continued) Editorials and Grant Review (continued)

Ad hoc Reviewer, Steroids Ad hoc Reviewer, Biology of Reproduction

Ad hoc Reviewer, Molecular and Cellular Endocrinology Ad hoc Reviewer, Journal of Assisted Reproduction and Genetics Ad hoc Reviewer, Molecular Human Reproduction Ad hoc Reviewer, Journal of Ovarian Research Ad hoc Reviewer, Journal of Assisted Reproduction and Genetics Ad hoc Reviewer, Board of Reviewing Editors for Biology of Reproduction Ad hoc Reviewer, Israel Science Foundation, March 24, 2015

Ad hoc Reviewer, Environment and Health Fund (EHF) in Israel, June 23, 2015 Ad hoc Study Section Reviewer: National Institute of Health-Cellular, Molecular

and Integrative Reproduction (CMIR), February 16, 2015 Reviewer, National Institute of Health- Reproduction, Andrology and Gynecology

Study Section 2015-19 Seminars Presented:

February 12, 2015 – “MicroRNA and Exosomes in the Periovulatory Follicle.” Department of Biology, University of Kentucky, Lexington, KY

Teaching Activities: GSMC 851 - Molecular Genetics (IGPBS) 2-2 hour lectures GSMC 852-Introduction to Biomedical Research (IGPBS)

2 hour lecture PHSL 851-Seminar

2-1 hour lectures Trainees: Wei-Ting Hung – Ph.D. Advisor: Exosomes in ovarian function

Jasmine Nwachokor –MS Clinical Research KUMC – (Co-Advisor for MS Clinical Res.): Serum Exosomal MicroRNA as a Clinical Biomarker for diagnosing Barrett’s Esophagus and Esophageal Adenocarcinoma

Pavla Brachova – Postdoctoral Fellow: The role of CD81 in follicular exosome function

Xiaoman Hong- Senior Research Associate Lynda McGinnis- Research Assistant Professor-Attained independent funding

(NIH-R21) under my supervision and a faculty position at the University of Southern California

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Salvatore J. Enna, Ph.D., Professor; Associate Dean for Research and Graduate Education; Professor, Department of Pharmacology, Toxicology and Therapeutics Research focused on neurotransmitters and neurotransmitter receptors, with particular emphasis on the structure, function and pharmacology of GABA receptors. Meetings Attended:

July 2014 – “Reproducibility of Data: Facts and Figures”, World Congress of Basic and Clinical Pharmacology Meeting, Cape Town, South Africa

February 2015 – “Alternative Approaches to Lead Generation”, Training in Neurotherapeutics Discovery and Development for Academic Scientists, Washington, D.C.

May 2015 – “IUPHAR Mission”, ASCEPT-BPT Joint Scientific Meeting, Hong Kong, China

July 2015 – “GABA Receptors and Cognition: Perspectives for Drug Development”, Summer School of Neuroscience, University of Catania, Catania, Italy

Committee Activities:

KUMC Associate Director, Internal Advisory Committee, Kansas University Training Program in Neurological and Rehabilitation Sciences Member, Research and Training Committee Member, Executive Research Committee National Chair, Nebraska-BRIN External Advisory Committee Member, PhRMA Foundation Pharmacology Advisory Panel Member, Research Advisory Council, University of Missouri-Kansas City

School of Pharmacy Member, GABA-B Nomenclature Database Committee Member, UMKC School of Pharmacy Research Advisory Council

Member, Institute of Medicine, Neuroscience Training Workshop Planning Committee International

President, Secretary General, International Union of Basic and Clinical Pharmacology Executive Committee

Editorials and Grant Reviews: Editor-in-Chief, Biochemical Pharmacology

Executive Editor-in-Chief, Pharmacology & Therapeutics Co-Editor, xPharm Co-Editor-in-Chief, Current Protocols in Pharmacology Series Editor, Advances in Pharmacology Guest Editor, Biological and Pharmaceutical Bulletin Section Head, Neuropharmacology and Psychopharmacology, Faculty of 1000 Pharmacology Section Editor, Reference Module in Biomedical Sciences

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Dr. Enna (continued) Editorials and Grant Review (continued)

Editorial Advisory Board Memberships: Brain Research Life Sciences CNS Drug Review Current Opinion in Pharmacology Chinese Medicine

Ad hoc Reviewer, Proceedings of the National Academy of Sciences USA Ad hoc Reviewer, Journal of Pharmacology and Experimental Therapeutics Consultant: Axinn Veltrop Harkrider LLP Seminars Presented:

October 2014 – “Alternative Approaches to Lead Generation”, University of Milan School of Medicine, Milan, Italy, October

October 2014 – “Preparing a Research Article”, University of Milan School of Medicine, Milan, Italy

Teaching Activities: Faculty Advisor Orr Society Mentor for:

Jason-Flor Sisante Linda D’Silva Josh Mark, Karin Valle (Preparation of NRSA Grant Proposal)

Graduate School of Pharmacy (Lawrence Campus) 3 hours Lecture Psychiatry Residents Lecture 2 hours Lecture PHSL 846 Advanced Neuroscience 3 – 2 hour lectures Graduate Students: Research Integrity

1 hour Directed Summer Research Integrity/Journal Club for T32 Students: 10 hours PHSL 848 Molecular Mechanisms in Neurological Disorders 2 – 2 hour Small Group Sessions 3 – 2 hour lecture

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Dr. Enna (continued) Associates Ms. Lynn LeCount, Managing Editor, Biochemical Pharmacology; Pharmacology

& Therapeutics; Pharmacology International, and Advances in Pharmacology

Ms. Jennifer McNichols, Editorial Coordinator, Biochemical Pharmacology; Pharmacology & Therapeutics, Pharmacology International, and Advanced in Pharmacology

Academic Honors:

Paoletti Medal from the European Pharmacology Society in Recognition of Significant and Sustained Contributions to Pharmacology Research and Training

Elected President of the International Union of Basic and Clinical Pharmacology

(IUPHAR)

UMKC School of Pharmacy Graduate School Distinguished Alumnus of the Year Award for Outstanding Service to the Pharmaceutical Profession, the Scientific Community, and to UMKC (Inaugural Recipient)

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Shawn Frost, Ph.D., Research Assistant Professor

Our laboratory studies neural plasticity in response to neurological injury and behavioral experience. We are interested in the underlying mechanisms of recovery after injury that can be used in the development of therapeutic interventions in treatment of stroke and brain injury. In a second project, we are currently developing an electronic aid to bridge the damaged spinal cord to connect the brain to spinal motor neurons below the level of injury. Meetings Attended:

October 15, 2014 – Poster Presentation: Output Properties of the Cortical Hindlimb Motor Area in Spinal Cord-Injured Rats, Authors: Frost SB, Dunham C, Krizsan-Agbas D, Winter MK, Meriwether J, Barbay S., Guggenmos D., Nudo RJ., SFNKC Annual Retreat and SCIRP Research Colloquium, Kansas City, KS

November 17, 2014 – Poster Presentation: The effects of intraspinal microsimulation parameters on movement thresholds in normal and spinal cord-injured rats Authors: Frost S.B., C. L. Dunham

, S. Barbay, DW McNeal D. W., D.Krizsan-Agbas , MK Winter, Guggenmos D. J., Nudo R.J., Society of Neuroscience 2014 Meeting, Kansas City, KS

Committee Activities: KUMC

Member, Society for Neuroscience, Kansas City Chapter Participant, Brain Awareness Week activities Editorials and Grant Reviews: Reviewer, Stroke (8/4/2014) Reviewer, Stroke (11/10/2014) Reviewer, Stroke (12/3/2014)

Seminars Presented: April11, 2015 –“The Gross Brain Anatomy.” KUMC Brain Fair, Kansas City, KS

May 20, 2015 –“Neuroscience: the scientific study of the nervous system.” Symington Elementary School, Kansas City, MO

Teaching Activities: CORE 840 – Brain and Behavior 20 hours lab PHSL 846 – Advanced Neuroscience 2 hours lecture Student Research Forum 1.5 hours - Workshop on Presentations Advisor to two Graduate Students

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Paige C. Geiger, Ph.D., Associate Professor Type 2 diabetes (T2D) is one of the leading causes of mortality and morbidity in the world. T2D is characterized by insulin resistance and is typically correlated with obesity and aging. In our lab, we study the molecular mechanisms underlying age-related and high fat diet-induced insulin resistance. We hypothesize that oxidative stress is responsible for inhibiting insulin signaling and for the impairment of glucose homeostasis. Stress kinases such as JNK and IKK-β are activated by oxidative stress and have recently been implicated in inhibiting insulin signal transduction. Thus, we are examining the targeted inhibition of stress kinases to improve insulin sensitivity. We are also exploring therapeutic interventions such as heat therapy, exercise and anti-oxidant treatment in high fat-fed rats. Meetings Attended:

April 16-17, 2015 – “Heat shock proteins in the Pathogenesis and Treatment of Type 2 Diabetes.” Climate Change: Biological Consequences of Heat Stress, Iowa State University

2014 – McLaughlin M, Geiger PC, Durham D. “How to Build a WIMS Organization on Limited Funds.” Consultation Breakfast Table Topics Proposal for AAMC Group on Faculty Affairs Conference 2014

Committee Activities: Departmental Member, Graduate Student Advisory Committee: Chair, Ashley Ward Archer Ph.D. candidate Chair, Robert Rogers Ph.D. candidate Member, David Wilson M.S. candidate Member, Jackie Thompson Ph.D. candidate Member, Narita Roy Ph.D. candidate Member, Isabella Fuentes Ph.D. candidate Member, Michael Cooper Ph.D. candidate Member, Kathleen M. Osborn Fellowship Committee Member, Seminar Committee KUMC Member, Exercise is Medicine Student Group Faculty Advisor

Member, American Medical Women’s Association Faculty Advisor Member, KUMC Research Advisory Committee Member, Emily Taylor Center for Women and Gender Equity Advisory

Board Member, Cray Diabetes Center Advisory Board Member, A Healthy U Workplace Wellness Program Physical Activity

Committee Member, KUMC Student Union Corporation Board Member, KUMC Lied Pilot Program Grant Review Member, Orr Society Faculty Advisor

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Dr. Geiger (continued) Editorials and Grant Reviews: Ad hoc Reviewer, American Journal of Physiology Endocrinology Ad hoc Reviewer, Metabolism Ad hoc Reviewer, American Journal of Physiology Cell Physiology Ad hoc Reviewer, Diabetes

Ad hoc Reviewer, Physiology Ad hoc Reviewer, Applied Physiology

Editorial Board Reviewer, American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

Reviewer, NIH Integrative Physiology of Obesity (IPOD) Study Section Reviewer, NIH/NIA Special Emphasis Panel Program Project Member, NIH Webinar on Molecular Mechanisms whereby Physical Activity

Benefits Health-Integrated Physiology

Seminars Presented: March 2, 2015 – “Obesity, insulin resistance and diabetes: Sex difference and

the role of estrogen receptors.” Department of Molecular and Integrative Physiology, Kansas City, KS

March 5, 2015 – “Heat shock proteins and mitochondrial function in the prevention of fatty liver disease and hepatic insulin resistance.” Novel Approaches in the Study of Liver Disease, Mini Symposium by KU Liver Center Disease Cobre, Kansas City, KS

April 24, 2015 – “The role of estrogen receptor alpha in control of energy balance and glucose homeostasis.” Institute of Reproductive Health and Regenerative Medicine, Kansas City, KS

Teaching Activities: PHSL 842 – Comprehensive Human Physiology 11 – 2 hour lectures CORE 815 – Cardiopulmonary Module, M1 Students 4 hours lecture 4 hours small group Integrative Physiology of Exercise 64-2 hour lectures Orr Society M1/M2 Advisor Trainees: Joshua Wheatley, MS – Research Associate

Robert Rogers, MA, PhD – Doctoral Student Ashley Ward Archer – Doctoral Student Kathleen White – M1, student volunteer David Wilson, KU-Lawrence Masters student Olivia Eller, IGPBS rotation student Camron Myers, SME High school student volunteer

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Dr. Geiger (continued) Trainees (continued)

Joseph Blond, KINBRE Summer Scholar, undergraduate Academic Honors: Glendon G. Cox Faculty Leadership and Excellence Award

Central Exchange Women in STEMM Inaugural STEMMY Award – Rising Trendsetter

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Norberto C. Gonzalez, M.D., Professor I am currently in the Phased Retirement program at 50% effort. This is my last year in the department. I have already closed my laboratory and terminated my last NIH R01 grant which was originally funded in 1988. Currently my research efforts consist of collaborations with colleagues, mainly Dr. Geiger and Dr. Wood from our Department, and Dr. Kasturi from Pharmacology. My research during the last several years has centered on the mechanisms of adaptation to alveolar hypoxia in intact animals. Alveolar hypoxia occurs when the environmental oxygen levels are reduced as it happens in altitude, or when pulmonary function is altered, as in COPD, ARDS, and restrictive pulmonary diseases. My laboratory has been involved in two main aspects of the effects of hypoxia in intact animals. One involves the mechanisms by which aerobic capacity is affected by hypoxia; these studies have been carried out in a rat model that allows the characterization of the systemic O2 transport from the atmosphere to the cell at rest and during maximal exercise. In these studies we have investigated the roles several factors on the determinants of maximal exercise capacity, including exercise training, changes in red blood cell mass and alterations of the affinity of Hb for O2. Longitudinal studies in rats artificially bred for diverging aerobic capacity have provided important clues on the development of the determinants of exercise capacity along several generations. The information obtained in these studies has helped advance the understanding of the role of hypoxia on the different steps of the O2 cascade from atmosphere to cell and, by extension, of the factors that determine aerobic capacity. A second major research theme has involved the mechanisms by which alveolar hypoxia induces systemic inflammation. In collaboration with Dr. Wood we carried out experiments in which the microcirculation was directly visualized in vivo. These studies showed that hypoxia induces systemic inflammation triggered by activation of alveolar macrophages, and demonstrated the sequence of events that lead from reduction in the alveolar O2 tension to the development of inflammation in the systemic microcirculation. This extrapulmonary effect of alveolar macrophage activation by hypoxia may be a contributory mechanism of the systemic effects frequently present in patients with systemic hypoxia originated by pulmonary diseases. Committee Activities: Departmental Chair, Departmental Appointments, Promotions and Tenure Committee

Member, Dissertation Committee for Robert Rogers, Ph.D. candidate Editorial and Grant Reviews: Editorial Board Reviewer, Hypoxia, Dove Press Reviewer, Welcome Trust, United Kingdom Reviewer, 2015 Fellowship Application Ad hoc Reviewer, The Journal of Applied Physiology Ad hoc Reviewer, Respiratory Physiology & Neurobiology

Ad hoc Reviewer, The American Journal of Physiology, Regulatory, Integrative and Comparative Physiology

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Dr. Gonzalez (continued) Editorials and Grant Review (continued)

Ad hoc Reviewer, American Journal of Physiology, Heart and Circulatory Physiology

Ad hoc Reviewer, The Journal of Physiology (London) Ad hoc Reviewer, Hypoxia Ad hoc Reviewer, PLOs One Ad hoc Reviewer, The European Journal of Applied Physiology Ad hoc Reviewer, Experimental Physiology

Ad hoc Reviewer, International Journal of Sports Medicine Seminars Presented:

June 18, 2015 – “What did you discover? Reflections on a lifetime of research in physiology” Department of Molecular and Integrative Physiology, KUMC

Teaching Activities: CORE 815 Respiratory Physiology, Cardiopulmonary Module 6 lectures 1 review session 3 – 2 hour small group meetings

CORE 860 Regulation of the acid-base balance, Integrative and Consolidation Module

1 lecture PHSL 835 – Integrative Physiology of Exercise 6 – 2 hour lectures Medical Student Mentoring 10 sessions

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Sumedha Gunewardena, Ph.D., Research Assistant Professor

Research Interest: Bioinformatics and computational genomics: modeling protein-DNA interactions, biological sequence analysis, microarray data analysis, biological pathways and network analysis, development of computational tools and databases. Published publication:

Bansal A, Hong X, Lee IH, Krishnadath KK, Mathur SC, Gunewardena S, Rastogi A, Sharma P, Christenson LK. "MicroRNA Expression can be a Promising Strategy for the Detection of Barrett's Esophagus: A Pilot Study". Clin Transl Gastroenterol. 2014 Dec 11;5:e65. doi: 10.1038/ctg.2014.17. PMID: 25502391 Butler MG, Wang K, Marshall JD, Naggert JK, Rethmeyer JA, Gunewardena SS, Manzardo AM. "Coding and noncoding expression patterns associated with rare obesity-related disorders: Prader-Willi and Alstrm syndromes". Adv Genomics Genet. 2015 Jan 27 Volume 2015:5 Pages 53-75. Chavan H, Li F, Tessman R, Mickey K, Dorko K, Schmitt T, Kumer S, Gunewardena S, Gaikwad N, Krishnamurthy P. "Functional coupling of ATP binding cassette transporter Abcb6 to Cytochrome P450 expression and activity in liver". J Biol Chem. 2015 Jan 26. pii: jbc.M114.605386. PMID: 25623066 Hendry WJ, Hariri HY, Alwis ID, Gunewardena SS, Hendry IR. "Altered gene expression patterns during the initiation and promotion stages of neonatally diethylstilbestrol induced hyperplasia/dysplasia/neoplasia in the hamster uterus". Reprod Toxicol. 2014 Dec;50:68-86. Kumaraswamy E,Wendt KL, Augustine LA, Stecklein SR, Sibala EC, Li D, Gunewardena S, Jensen RA. "BRCA1 regulation of epidermal growth factor receptor (EGFR) expression in human breast cancer cells involves microRNA-146a and is critical for its tumor suppressor function". Oncogene. 2014 Nov 24. Paul A, Gunewardena S, Stecklein SR, Saha B, Parelkar N, Danley M, Rajendran G, Home P, Ray S, Jokar I, Vielhauer GA, Jensen RA, Tawk O, Paul S. "PKC- lambda/iota signaling promotes triple-negative breast cancer growth and metastasis". Cell Death Di er. 2014 Sep;21(9):1469-81. Wang H, Graham I, Hastings R, Gunewardena S, Brinkmeier ML, Conn PM, Camper SA, Kumar TR. "Gonadotrope-specifc Deletion of Dicer Results in Severely Suppressed Gonadotropins and Fertility Defects". J Biol Chem. 2015 Jan 30;290(5):2699-714. doi: 10.1074/jbc.M114.621565. Epub 2014 Dec 18. PMID: 25525274

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Leslie L. Heckert, Ph.D., Marion M. Osborn Professor for Reproductive Sciences The research in our laboratory focuses on the transcriptional and cell-signaling processes for proper function and development of the gonads. Sequence and structural information of the genome are queried to identify new proteins and regulatory pathways that direct cellular differentiation and gametogenesis, with the goal of extending our understanding of the mechanistic requirements for fertility, as a means to improve the options for contraception as well as diagnosis and treatment of infertility. Current research is focused on genes that encode the follicle-stimulating hormone receptor (FSHR) and doublesex and mab-3 related transcription factor 1 (DMRT1) and using genome editing technology to evaluate the function of predicted regulatory elements in vivo. FSHR is required for cells to respond to the pituitary hormone FSH and thus hormone signaling occurs only in cells that produce the receptor. FSHR expression is highly cell-specific, limiting FSH response to only somatic cells of the gonads. DMRT1 is a transcription factor that is essential for male fertility. It is found only in the testis, where it is required for the differentiation and survival of both germ cells and Sertoli cells. Committee Activities: Departmental Member, Graduate Student Advisory Committee Member, Department Finance Committee Member, Promotions & Tenure Committee KUMC Member, IGPBS Curriculum Development and Oversight Committee Member, Transgenic and Gene Targeting Core Oversight Committee Member, Institutional Biosafety Committee Member, Research Misconduct Committee National Member, Program Committee, XXII North American Testis workshop

Member, Future Meetings Committee, Society for the Study of Reproduction

Vice Chair, XXII North American Testis Workshop Chair, Abstract Review Committee, XXII North American Testis Workshop Chair, XXIV North American Testis Workshop Editorial and Grant Reviews: Reviewer, Lied Basic Science grant applications Reviewer, KIDDRC Letters of Intent

Ad hoc reviewer, Biology of Reproduction Editorial Board Member, Endocrinology

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Dr. Heckert (continued) Trainees: Valentine Agbor, Ph.D. – Post Doctoral Volunteer

81

T. Rajendra Kumar, Ph.D., Professor, Director of the Center for Reproductive Sciences Our laboratory studies development and regulation of the hypothalamus-pituitary-gonadal (HPG) axis using both gain-of-function transgenic and loss-of-function gene knockout approaches. These unique genetic models mimic many of the human diseases and thus enable us to experimentally tract them spatio-temporally. Specific projects include unraveling signaling pathways in the hypothalamus that contribute to male sexual behavior, understanding human pituitary null cell tumor pathobiology and developing preventive strategies, delineating mechanisms of secretion of pituitary gonadotropins, and age-dependent gonadotropin regulation of testis and ovarian development and function. These translational studies have significant impact in understanding the physiology and pathology of the reproductive axis including abnormal reproductive tract development, infertility, and cancer of the pituitary and gonads. Meetings Attended:

August 23, 2014 – “Genetic models for human pituitary null cell adenoma.” National Pituitary Conference, Kansas City, KS

September 9, 2014 – “Gonadotrophin re-routing and ovarian gene networks.” International Conference on Gonadotrophin Receptors III, Tours, France

January 13, 2015 – “Gonadotrophin re-routing and ovarian function.” UT Southwestern Medical School-Reproductive Biology Seminar Series, Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Department of Obstetrics and Gynecology, Dallas, TX

February 10, 2015 – “Genetics and Physiology of FSH secretion.” Department of Obstetrics and Gynecology, University of Colorado Denver School of Medicine, Aurora, CO

February 27, 2015 – “FSH signaling in ovarian function and osteoporosis in post-menopausal women.” Ansh Labs, Webster, Texas

March 8, 2015 – “Regulation of distinct GPCR pathways by age-specific FSH analogs.” Endocrine Society 97th Annual Meeting, Symposium on “GPCR Function in the HPG Axis, San Diego

March 28, 2015 – “Genetic Modification of Pituitary Gonadotropic Hormone Trafficking and Secretion.” The American Society for Pharmacology & experimental Therapeutics- FASEB, Symposium on “Protein trafficking as a target for drug development, Boston, MA

June 1, 2015 – “FSH signaling in ovarian and bone function.” Department of Oral and Craniofacial Sciences, University of Missouri, Kansas City, KS

June 18, 2015 – “Gonadotrophin re-routing and evolution of estrus cycles.” 48th Annual Meeting of the Society for the Study of Reproduction, Symposium on “Neuroendocrine Control of Reproduction-some things old, some things new, some things borrowed, some things left to pursue.” San Juan, Puerto Rico

Committee Activities: Departmental Chair, Osborn Endowment Student Scholar Funding Committee

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Dr. Kumar (continued) Committee Activities (continued)

Member, Department of Molecular & Integrative Physiology Seminar Committee

Judge, Physiology Society Travel Award Applications Evaluation Committee

Member, Department of Molecular & Integrative Physiology, Promotions & Tenure Committee

Member, Thesis Committee, N.K. Neradugomma Member, Thesis Committee, Jessica Johnson Member, Thesis Committee, Kira Marshall Member, Thesis Committee, Michelle McWilliams Member, Thesis Committee, Mina Farabaksh Member, Thesis Committee, Zelha Nil Member, Thesis Committee, Afreen Sayed KUMC

Member, IGPBS Students’ Recruitment Committee Member, Faculty Evaluation Committee Ad-hoc Member, Faculty Hearing Committee Member, MD/PhD Student’s Selection Committee

National July 19-23, 2014: Invited Member, 2014 SSR Program Committee, Grand

Rapids, MI. July 19-23, 2014: Lead Reviewer, SSR 2014 Abstract Evaluations,

Sections: Endocrinology: Gonadotropins & Endocrinology: Other, Grand Rapids, MI.

July 19-23, 2014: Chair, Neuroendocrine Module, SSR 2014 Annual Meeting, Grand Rapids, MI.

June 2015 – June 2016: Invited Member, SSR Nominating Committee 2014-2017: Member, Endocrine Society Research Affairs Core

Committee. 2014 – 2016: Endocrine Society Member Representative, FASEB Science

Research Conference Advisory Committee. March 2015: Endocrine Society 2015 Annual Meeting at San Diego,

Judge to evaluate Presidential Posters. March 2015: Chair, Platform Session on “Basic and Clinical Aspects of

Sexual Reproduction”, Endocrine Society 2015 Annual Meeting at San Diego.

March 2015: Member, US Capitol Hill Visiting Team from the Endocrine Society Research Affairs Core Committee, Represented the State of Kansas.

2014-2017: Review Member, FASEB SRCAC proposals’ Evaluation Committee, Invited nominee from the Endocrine Society Research Advisory Core Committee

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Dr. Kumar (continued) Committee Activities (continued)

December 2014: Expert Referee for evaluating Graduate Student’s Pre-Thesis Submission, Physiology Section, Faculty of Medicine, University of Cordoba, Spain.

Editorial and Grant Reviews: Associate Editor, Molecular Reproduction and Development Senior Editor, Journal of Assisted Reproduction and Genetics Editorial Board Reviewer, Biology of Reproduction Reviewer, American Journal of Physiology: Endocrinology &

Metabolism Reviewer, Biochemica Biophysica Acta (Molecular and Cellular Research) Reviewer, Biology of Reproduction Reviewer, BMC Cell Biology Reviewer, Cell and Tissue Research Reviewer, Clinical Endocrinology Reviewer, Development Reviewer, Developmental Biology Reviewer, Endocrine Reviewer, Endocrine-Related Cancer Reviewer, Endocrinology Reviewer, FEBS Letters Reviewer, Fertility and Sterility Reviewer, Genesis Reviewer, Genomics Reviewer, Hormones & Cancer Reviewer, Journal of Andrology Reviewer, Journal of Assisted Reproduction and Technology Manuscript Reviewer, Journal of Cell Biology Reviewer, Journal of Cell Science Reviewer, Journal of Clinical Endocrinology & Metabolism Reviewer, Journal of Clinical Investigation Reviewer, Journal of Endocrinology Reviewer, Journal of Urology Reviewer, Molecular and Cellular Biology Reviewer, Molecular and Cellular Endocrinology Reviewer, Molecular Endocrinology Reviewer, Molecular Reproduction and Development Reviewer, Oncogene Reviewer, PLOS ONE Reviewer, PLOS Genetics Reviewer, Proceeding of the National Academy of Sciences (USA) Reviewer, Physiology & Behavior Reviewer, Physiological Genomics Reviewer, Reproduction Reviewer, Reproductive Biology Reviewer, Reproductive Biology and Endocrinology Reviewer, Reproductive Sciences

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Dr. Kumar (continued) Editorials and Grant Review (continued)

Reviewer, RNA Reviewer, Science Reviewer, The FASEB Journal Reviewer, Trends in Endocrinology and Metabolism

Seminars Presented: January 7, 2015 – “Constructive versus Regulated Hormone Secretion and

Ovarian function” Center for Reproductive Sciences, Chalk Talk, Seminar to KUMC IRHRM/CRS Faculty Members

Teaching Activities: Advanced Developmental Biology; Anatomy – 868 2 – 4 hour Lectures Tumor development; Cancer Biology – 800 2 – 3 hour Lectures Trainees: Dr. Huizhen Wang, Ph.D., Senior Scientist

Ian Graham, Technician Jacob May, Technician Dr. Kyle Smith, Neurosurgery Resident Saurabh Harohalli, Summer Student Avani Sharma, Summer Student Pranav Rao, Summer Student Yashi Wang, Summer Volunteer

Academic Honors: Promoted to Professor, Department of Molecular & Integrative Physiology Appointed as Director, Center for Reproductive Sciences, Institute for Reproductive Health and regenerative Medicine August 13, 2014 – “Functional genomics of pituitary gonadotropins” Ansh Labs, Webster, TX August 23, 2014 – “Genetic models for human pituitary null cell adenoma” National Pituitary Conference, Kansas City, KS September 9, 2014 – Invited Speaker – “Gonadotropin re-routing and ovarian gene networks” International Conference on Gonadotropins and Gonadotropin Receptors III, Tours, France January 13, 2015 – “Gonadotropin re-routing and ovarian function” UT Southwestern’s Reproductive Biology Seminar Series, Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Department of Obstetrics and Gynecology, Dallas, TX

March 8, 2015 – Invited Speaker – “Regulation of distinct GPCR pathways by 2014: Appointed Director, Center for Reproductive Sciences, Institute of Reproductive Health and Regenerative Medicine

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Dr. Kumar (continued) Academic Honors (continued)

2014: Outstanding Reviewer Award for 2013, Endocrine Society- Molecular Endocrinology Journal

2015: Certificate of Outstanding Contribution in Reviewing for 2014, Molecular and Cellular Endocrinology, Elsevier Press, Amsterdam, The Netherlands

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Melissa A. Larson, Ph.D. Research Assistant Professor, Director of KUMC Transgenic and Gene-Targeting Institutional Facility The TGIF is a fee-for-service facility supporting the research efforts of investigators at KUMC and the surrounding research community. In this capacity, we are providing the services of generation of transgenic and chimeric mice, targeting of embryonic stem cells, genotyping, sperm and embryo cryopreservation, rederivation by embryo transfer and in vitro fertilization. We also provide consultation, demonstration and training on construct generation, embryo handling and mouse surgeries and will be adding the service of intracytoplasmic sperm injection. We welcome the opportunity to research new projects, and we are developing new techniques and services to offer to investigators. My lab is also investigating the in vivo function of a novel recombinase for use in genetic engineering. Committee Activities: KUMC Member, Institutional Animal Care and Use Committee Member, Programmatic Sub-Committee of the Institutional Animal Care

Use Committee Member, Women in Medicine and Science Mentoring Committee Co-Chair, Women in Medicine and Science Mentoring Committee Member, Institutional BioSafety Committee National Representative, American Association for Laboratory Animal Science on

behalf of the International Society for Transgenic Technologies Seminars Presented:

October 3, 2014 – Current Issues in Biotechnology, “Transgenic and Gene-Targeting Facility” Department of Clinical Laboratory Sciences, University of Kansas Medical Center, Kansas City, KS

Trainees: Suwen Wei, Senior Research Associate

Illya Bronshteyn, Research Associate

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Phil Lee, Ph.D., Associate Professor

Dr. Lee received his Ph.D. in Biophysical Sciences and Medical Physics from University of Minnesota. His research topic was the physiological bases of functional magnetic resonance imaging (MRI) signals and development of novel non-invasive magnetic resonance techniques for the biophysical investigation. Dr. Lee’s current research interests include the characterization and understanding of biological processes in the neurodegenerative brain at the cellular, molecular and functional levels using in vivo bioengineering approaches including state-of-the-art magnetic resonance techniques. Meetings Attended:

October 29-30, 2014 – Faculty Research Day Participation, KUMC Research Institute, Kansas City, KS I.-Y. Choi, P. Lee, D. R. Denney, K. Spaeth, O. Nash, A. K. Roth, J. A. Lierman,

D. K. Sullivan, The association between dairy intake and brain glutathione levels in older adults, 2014 Faculty Research Day and Poster Session

P. Adany, P. Lee, I.-Y. Choi, Performance Optimized Lipid Artifact Removal (POLAR) with BASE-SLIM, 2014 Faculty Research Day and Poster Session

J. L. Harris, H.-W. Yeh, I.-Y. Choi, P. Lee, R. Swerdlow, W. M. Brooks, " Neuroimaging biomarkers reveal mechanisms of traumatic injury in the aged brain" 2014 Faculty Research Day and Poster Session

Committee Activities: KUMC Director, MR Technology at the Hoglund Brain Imaging Center Editorials and Grant Reviews: Ad hoc Reviewer, Frontiers in Neurology

Ad hoc Reviewer, International Journal of Molecular Sciences

Ad hoc Reviewer, Journal of Magnetic Resonance Imaging

Ad hoc Reviewer, Magnetic Resonance Materials in Physics, Biology and Medicine

Ad hoc Reviewer, Metabolic Brain Disease

Ad hoc Reviewer, Neurochemical Research

Ad hoc Reviewer, NMR in Biomedicine

Reviewer, Conference proceedings of International Society for Magnetic Resonance in Medicine

Reviewer, Conference proceedings of Human Brain Mapping

Teaching Activities: PHSL 846/ANAT 846 – Advanced Neuroscience 2 hours lecture 9.4T MRI New Users Workshop discussion 1 hour

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Dr. Lee (continued) Teaching Activities (continued)

National Multiple Sclerosis Research Meeting 3 hours Advisor:

Graduate Students: Andrea Nuckolls, Mark Burghart, Rodrigo Dennis Perea

Resident: Rawan Albadareen M.D. Other Activities:

Consultant of MR program of Center for Brain, Biology and Behavior at University of Nebraska

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Steven M. LeVine, Ph.D., Professor Our research is directed at advancing the understanding of the pathogenic mechanism in multiple sclerosis, which is a neurological disease that causes sensory, motor and/or cognitive declines. We also study experimental interventions for this disease. Our research incorporates a team approach that includes clinical samples, immunology, and animal models. Additional studies address intervention strategies for Krabbe’s disease (a.k.a., globoid cell leukodystrophy). We also study mechanisms of toxin and bacterial induced vessel injury. Meetings Attended:

April 30, 2015 – 6th Annual University of Toronto Neuroinflammation Symposium and Manitoba – Ontario endMS Regional Research and Training Centre Retreat. Invited Plenary Speaker. Toronto, Canada

April 29, 2015 – ApoPharma, Inc. Invited seminar, Toronto, Canada July 27-29, 2014 – Hunter’s Hope Annual Medical and Science Symposium,

Ellicottville, NY

Committee Activities: Departmental Member, Graduate Student Advisory Committee Member, Thesis Committee for Mohammed Khan Member, Thesis Committee for Jason Gill Member, Qualifying exam committee for Asona Lui Member, Qualifying exam committee for Margaret Pruitt KUMC Member, Safety Committee for the Smith East Building Member, Multiple Sclerosis Research Group Editorials and Grant Reviews:

Ad hoc Reviewer, Journal of Neuroscience Research Ad hoc Reviewer, Journal of Neurological Sciences Ad hoc Reviewer, Neurobiology of Disease Ad hoc Reviewer, PLoS One Ad hoc Reviewer, Science Translational Medicine

Reviewer, 2 pilot grants for the Frontiers Inter-Institutional Pilot Program Founding Editor & Member of Editorial Board, NeuroMetals

Seminars Presented:

May 4, 2015 – Iron deposition in multiple sclerosis: experimental models reveal insights about disease mechanisms (half seminar). Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS

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Dr. LeVine (continued) Seminars Presented (continued)

May 15, 2015 – “Iron deposition in multiple sclerosis: experimental models reveal insights about disease mechanisms.” University of Kansas Medical Center, Kansas City, KS

Teaching Activities: CORE 820 – Gastrointestinal Tract and Nutrition 5 hours lecture to first year medical students CORE 840 – Brain, Mind and Behavior ~4 hours of Neuropathology Labs for second year medical students NURO 848 – Molecular Mechanisms of Neurological Disorders 1 hour group session 2 hour lecture PHSL 848 – Molecular Mechanisms of Neurological Disorders 2 hours lecture ANAT 848 – Molecular Mechanisms of Neurological Disorders 2 hours lecture PHSL 842 – Comprehensive Human Physiology 4 hours lecture to graduate students 1 hour paper discussion Trainees: Scott Sands, Ph.D. – Post-Doctoral fellow Sheila Tsau – Research Associate Douglas Brandt – DVM Other Activities:

Led a preview session for Faculty for one of the Neuropathology Labs for the second year medical students in the Brain, Mind and Behavior (CORE 840) course, Fall 2014

Reviewer for a proposal sent to the Stanford Synchrotron Radiation Light source

for access to beam time

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Warren B. Nothnick, Ph.D., Professor The uterus is a vital organ for the successful propagation of all higher species.

Understanding the molecular mechanisms that contribute to the development and

subsequent function of the uterus are absolutely essential for successful reproduction to

occur. It is well established that complex interactions among biological mediators

dictate the normal pattern of uterine development and that disruption of these factors

plays a causative role in uterine abnormalities, disease and infertility. Our research

focuses on three major areas:1) the role of microRNAs (miRNAs) in the

pathophysiology of the female disease, endometriosis, 2) the role of miRNAs in uterine

decidualization and early pregnancy loss/embryo implantation insufficiencies, and 3) the

identification and development of novel, estrogen-sparing targets for endometriosis

treatment. Collectively, the research in my laboratory focuses on examining the

mechanisms which regulate normal uterine development and function, identifying those

factors which contribute to these mechanisms and understanding how alterations in

these mechanisms lead to uterine diseases such as endometriosis and recurrent

pregnancy loss/infertility. The long-term goal of the research conducted in my laboratory

is to better our understanding of the pathophysiology of these uterine diseases and in

turn develop novel diagnostic/prognostic markers and therapeutic agents for their

treatment.

Meetings Attended: March 25-28, 2015 – Society for Reproductive Investigation, San Francisco, CA Committee Activities: Departmental Member, Doctoral Dissertation Committee for Wei-Ting Hung Member, Department of Molecular & Integrative Physiology, University of

Kansas Medical Center, Departmental Promotion and Tenure Committee, 2014 – present

Member, Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Finance Committee, 2014-present

KUMC Chairman, Laboratory Animal Resources Advisory Committee for the University of Kansas Medical Center, 2013 – present Scientific Director, Laboratory Animal Resources; University of Kansas Medical Center, 2013 – present

Member, Advisory Committee for the University of Kansas Medical Center Institutional Official, 2013-present

Member, The Gilbert S. Greenwald Reproductive Biology Symposium Planning Committee, 2013-present

Member, Strategic planning committee, Center for Reproductive Sciences, University of Kansas Medical Center, 2014 – present

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Dr. Nothnick (continued) Editorial and Grant Reviews: Ad hoc Reviewer, American Journal of Obstetrics and Gynecology

Ad hoc Reviewer, Biology of Reproduction Ad hoc Reviewer, Endocrinology Ad hoc Reviewer, Fertility and Sterility Ad hoc Reviewer, Gynecologic and Obstetric Investigation Ad hoc Reviewer, Human Reproduction Ad hoc Reviewer, Journal of Assisted Reproduction and Genetics Ad hoc Reviewer, Journal of Clinical Endocrinology and Metabolism Ad hoc Reviewer, Molecular Endocrinology Ad hoc Reviewer, Molecular Human Reproduction Ad hoc Reviewer, Molecular Reproduction and Development Ad hoc Reviewer, PLoS ONE Ad hoc Reviewer, Reproduction Ad hoc Reviewer, Reproductive Biology and Endocrinology Ad hoc Reviewer, Reproductive Sciences Ad hoc Reviewer, Israel Science Foundation (ISF), 2014 Standing Member, NIH/EMNR Initial Review Group, Integrative and Clinical

Endocrinology and Reproduction Study Section (ICER), July 1, 2013 – June 30, 2017.

Vice-Chair, NIH/EMNR Initial Review Group, Integrative and Clinical Endocrinology and Reproduction Study Section (ICER), June 11 - 12, 2015.

Vice-Chair, NIH/EMNR Initial Review Group, Integrative and Clinical

Endocrinology and Reproduction Study Section (ICER), February 12 -13,

2015.

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Randolph J. Nudo, Ph.D., Professor & Vice-Chair of Research, Director of The Landon Center on Aging My research focuses on neural mechanisms of repair after brain injury, using modern electrophysiological, neuroanatomical and behavioral techniques. Currently I am studying the capacity for functional plasticity in primary motor cortex of adult primates. Recent experiments have demonstrated that the functional organization of cerebral cortex is alterable throughout life. Plastic changes in cortical "maps" may reflect basic adaptive processes underlying functional recovery from brain injury, learning and memory. By tracking changes that occur in the motor cortex as a result of stroke, we hope to provide a simple model of neurophysiological processes operating in recovery of motor function. We are also investigating the development and application of neuroprosthetic microdevices that interface with the brain to repair communication links within after injury. Thus, this research program has great significance for the development of future rehabilitation approaches that are based on the underlying principles of brain plasticity. Techniques used in our laboratory include intracortical microstimulation mapping, multi-unit and single-unit recordings, behavioral training, ischemic lesion techniques, neuroanatomical tract tracing, Golgi impregnation and analysis of dendritic arborization, immunocytochemistry, electron microscopic analysis of synapse numbers, microarray analysis of gene expression. These studies have led to the development of a translational research program that is now moving interventions for stroke recovery from the bench to the clinic. Meetings Attended:

December 18, 2014 - Invited Speaker, “Shaping plasticity to enhance recovery after brain injury.” Peter Jay Sharp Foundation Visiting Professor in Neurological Rehabilitation, Division of Rehabilitation Medicine, Weill Cornell Medical College, New York, NY

February 10, 2015 - Invited Speaker, “Targeting the contralesional hemisphere for post-stroke recovery: Influence of rehabilitative training and non-invasive brain stimulation.” International Stroke Conference, Nashville, TN

March 2, 2015 – Keynote Speaker, “Closed-loop approaches for enhancing recovery after brain and spinal cord injury.” 1st International Brain Stimulation Conference, Singapore

March 2015 – Keynote Speaker, “Applications of closed-loop approaches to therapeutic brain stimulation.” International Workshop on Clinical Brain-Machine Interface Systems, Tokyo Japan

April 2015 – Invited Speaker, “Adaptive stimulation approaches to enhancing neuroplasticity and behavioral recovery after brain injury.” Symposium on Motor Control Satellite Meeting, Charleston, SC

May 2015 – Keynote Speaker, European Conference on NeuroRehabilitation, Maastricht, The Netherlands

Committee Activities: Department T32 Mentor, Neurological and Rehabilitation Sciences Training Program

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Dr. Nudo (continued) Committee Activities (continued)

KUMC Member, International Advisory Board for Interdisciplinary Geriatric

Education Co-Director, Brain Injury and Repair Division, Institute for Neurological

Discoveries Co-Chair, Scientific Advisory and Review Committee, Heartland Institute

for Clinical and Translational Research Center Chair, Internal Advisory Committee, University of Kansas Alzheimer’s

Disease Center Director, KL2 training program, Heartland Institute for Clinical and

Translational Research Center National

Member, External Advisory Committee, NIH COBRE (Center for Research in Human Movement Variability), University of Nebraska, Omaha, NE

Member, National Advisory Board on Medical Rehabilitation Research, NICHD-NIH

Member, External Advisory Board, T32 in Predoctoral Training of Neuroscientists, University of Minnesota, Minneapolis, Minnesota

Board Member, 2015 International Workshop on Clinical Brain-Machine Interfaces

Editorial and Grant Reviews: Editor-in-Chief: Neurorehabilitation and Neural Repair (2013-present)

Deputy Editor: Brain Stimulation, Basic, Translational and Clinical Research in Neuromodulation

Associate Editor: Restorative Neurology and Neuroscience Member, editorial board: Neuroscience and Biobehavioral Reviews Member, editorial board: Frontiers in Neuroprosthetics (2013-present) Ad hoc Reviewer, Stroke Ad hoc Reviewer, Journal of Comparative Neurology Ad hoc Reviewer, Somatosensory and Motor Research Ad hoc Reviewer, Journal of Neuroscience Methods Ad hoc Reviewer, Cerebral Cortex Grant Reviewer, Italian Multiple Sclerosis Society Grant Reviewer, NIH-NICHD Loan Repayment Program Grant Reviewer, Italian Ministry of Education, University and Research (MIUR)

Ad hoc Reviewer, Annals of Neurology Ad hoc Reviewer, Archives of Physical Medicine and Rehabilitation Ad hoc Reviewer, Behavioural Brain Research Ad hoc Reviewer, Brain Ad hoc Reviewer, Brain Research Ad hoc Reviewer, Brain Stimulation

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Dr. Nudo (continued) Editorial and Grant Reviews (continued)

Ad hoc Reviewer, Brain Structure and Function Ad hoc Reviewer, Cerebral Cortex Ad hoc Reviewer, Clinical Neurophysiology Ad hoc Reviewer, Cognitive Ad hoc Reviewer, Affective and Behavioral Neuroscience Ad hoc Reviewer, European Journal of Neuroscience Ad hoc Reviewer, Exercise and Sport Sciences Reviews Ad hoc Reviewer, Experimental Brain Research Ad hoc Reviewer, Human Brain Mapping

Ad hoc Reviewer, IEEE Transactions on Neural Systems and Rehabilitation Engineering

Ad hoc Reviewer, Institute for Laboratory Animal Research Journal Ad hoc Reviewer, Journal of Cerebral Blood Flow and Metabolism Ad hoc Reviewer, Journal of Comparative Neurology Ad hoc Reviewer, Journal of Neural Engineering Ad hoc Reviewer, Journal of Neurophysiology Ad hoc Reviewer, The Journal of Neuroscience Ad hoc Reviewer, Journal of Neuroscience Methods Ad hoc Reviewer, Learning and Memory Ad hoc Reviewer, Motor Control Ad hoc Reviewer, Nature Reviews Neuroscience Ad hoc Reviewer, Neurobiology of Learning and Memory Ad hoc Reviewer, Neuropharmacology, Neurocase Ad hoc Reviewer, Neurorehabilitation and Neural Repair Ad hoc Reviewer, Neuroscience, Neurotherapeutics Ad hoc Reviewer, Proceedings of the National Academy of Sciences Ad hoc Reviewer, Somatosensory and Motor Research Ad hoc Reviewer, Stroke Ad hoc Reviewer, Vision Research

Seminars Presented:

June 2014 - Invited Speaker, III Workshop of Synaptic Plasticity: From Bench to Bedside, Milazzo, Sicily

December 18, 2014 - Invited Speaker, “Shaping plasticity to enhance recovery after brain injury.” Peter Jay Sharp Foundation Visiting Professor in Neurological Rehabilitation, Division of Rehabilitation Medicine, Weill Cornell Medical College, New York, NY

February 10, 2015 - Invited Speaker, “Targeting the contralesional hemisphere for post-stroke recovery: Influence of rehabilitative training and non-invasive brain stimulation.” International Stroke Conference, Nashville, TN

March 2, 2015 - Keynote Speaker, “Closed-loop approaches for enhancing recovery after brain and spinal cord injury.” 1st International Brain Stimulation Conference, Singapore

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Dr. Nudo (continued) Seminars Presented (continued)

March 2015 - Keynote Speaker, “Applications of closed-loop approaches to therapeutic brain stimulation.” International Workshop on Clinical Brain-Machine Interface Systems, Tokyo, Japan

April 2015 - Invited Speaker, “Adaptive stimulation approaches to enhancing neuroplasticity and behavioral recovery after brain injury.” Symposium on Motor Control Satellite Meeting, Charleston, SC

May 2015 - Keynote Speaker, European Conference on NeuroRehabilitation, Maastricht, The Netherlands

Teaching Activities: Faculty Research Series 1 hour lecture Advanced Rehabilitation 4 hours of lectures Pathobiology of Human Function II 1 hour lecture PHSL 848 Molecular Mechanisms of Neuro Disorders 1 hour lecture Introduction to Clinical Research 4 hours of lecture T32 Mentor/Training Program: Fall: 2 students Spring: 2 students Trainees:

David Guggenmos, Ph.D., Neuroprosthetic repair after traumatic brain injury Shawn Frost, Ph.D., Scott Barbay, Ph.D. Heather Hudson, Ph.D., Anatomical changes after closed-loop stimulation post-

traumatic brain injury. David Bundy, Ph.D., Event-related local field potential recordings in rodents. Caleb Dunham, Ph.D. Hongyu Zhang, Ph.D. Jordan Borrell, Project Title: Topographical Mapping of the Outputs to Hindlimb

Muscles using Intraspinal Microsimulation. Max Murphy, Project Title: Describing spike-timing dependent synaptic

modification for use with a rehabilitative brain-computer interface.

Other Activities: Patent Applications:

2015 U.S. Patent No. US 9,008,780 B2 “Methods and Associated Neural Prosthetic Devices for Bridging Brain Areas to Improve Function”. Inventors: Randolph J. Nudo, David Guggenmos, Pedram Mohseni, Meysam Azin

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Dr. Nudo (continued) Academic Honors:

Keynote Speaker, European Conference on NeuroRehabilitation, Maastricht, The Netherlands, May 2015.

Invited Symposium Speaker, International Stroke Conference, American Heart Association, Nashville, Tennessee, February 2015.

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Prabhu Ramamoorthy, Ph.D., Research Assistant Professor Colorectal cancer is a major malignancy worldwide and is the second leading cause of cancer death in the United States. Treatment and prevention of colon cancer is often unsuccessful and has an extremely high morbidity rate. The major feature of solid tumors is hypoxia; the decreased availability of oxygen has been shown to increase chemotherapy resistance thereby favoring tumor progression. Hypoxia and heat shock protein 90 (HSP90) stabilize HIF-1α (hypoxia inducible protein-1α), a transcription factor that regulates expression of vascular endothelial factor (VEGF) and inducible nitric oxide synthase (iNOS). In contrast, HSP90 inhibitors inhibit the expression of VEGF and iNOS suggesting that HSP90 is a critical player in HIF-1α mediated expression of these genes. My research focuses on understanding the mechanism of hypoxia-mediated regulation of cancer stem cells and the effect of hypoxia on hypoxia inducible factor. In addition, to determine the effect of natural HSP90 inhibitors, celastrol and triptolide on the growth and tumor formation of cancer stem cells. Addition to this, isolating cancer cells from fresh human cancer patient sample and to try HSP90 inhibitor with and without hypoxia. Committees KUMC Member, Enhanced Academic Club

Member, Dissertation Committee for T. Kavitha Rajathi Member, Faculty Position Search Cancer Biology Committee Editorials and Grant Reviews: Ad hoc Reviewer, PLOS ONE Ad hoc Reviewer, Environmental Toxicology Ad hoc Reviewer, Chemical Biology & Drug Design Ad hoc Reviewer, Applied Physiology Nutrition and Metabolism Seminars Presented:

May 17-19, 2015 –“Ramamoorthy R, Satish R, Dharmalingam S, Prasad D, Ossama T, Roy A J, Joaquina CB, Scott JW, Mojtaba SO, Subhash P, Gurusingham SS, Shrikant A. A Novel “Tumor in a Dish” Method to Study Primary and Metastatic Colon Cancer; Differential Therapeutic Responses in Cancers with Mismatch Repair Defects. Digestive Disease Week, Washington, DC.

Trainees: Dr. Katherine Chastain, Children Mercy Hospital - Sarcoma in a Dish Project

Dr. Seth Septer, Children Mercy hospital -Familial Adenomatous Polyposis project

Dr. Sreekar, VA Kansas City- Biomarker and Barrett Esophagus in a Dish project Dr. Prasad Dandawate, Postdoctoral Fellow Dr. Parthasarathy Rangarajan, Postdoctoral Fellow Afreen Syed, Graduate Student

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Peter G. Smith, Ph.D., Professor Director of the Institute for Neurological Discoveries, Co-Director of the Kansas Intellectual and Developmental Disabilities Research Center, Senior Associate Dean for Research Nerves regulate function and structure of target cells. In turn, target cells provide molecular signals that govern the quantity and type of innervation they receive. Our research is concerned with this interplay between nerves and targets in controlling end organ activity and in processing sensory signals. We are particularly interested in how hormones and vitamins can regulate neuronal function in conditions such as chronic pain syndromes, the role of renin-angiotensin systems in sensory nerve growth and sensitization, and how genetic variants can lead to developmental neurological disorders. Committee Activities: Departmental

Member, Student Advisory Committee for Angela Pierce Member, Student Advisory Committee for Li Zhou

KUMC Director, Frontiers Pilots and Collaborative Research Projects program, CTSA Member, Anesthesiology Chair Search Committee Chair, KUMC Genomics Core Advisory Committee Member, Mass Spectroscopy Advisory Board Member, Research Institute Executive Director Search Committee Affiliate Member, KU Cancer Center Member, Alzheimer’s Disease Center Internal Advisory Board, and Executive Committee Chair, Ad Hoc committee on Research Grant Bridging Policies Chair, Executive Committee, Institute for Neurological Discoveries Chair, Woodyard Fellowship in Neurodegenerative Disorders Selection Committee Chair, NexGen Sequencing Pilot Awards Selection Committee Director, Spinal Cord Injury Repair Program Member, Cross Campus IT Committee Member, Research Advisory Council

National North American Representative to the Executive Committee, International

Society for Autonomic Neuroscience Member, Board of Trustees, National Parkinson Foundation Heartland

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Dr. Smith (continued) Editorials and Grant Reviews: Ad hoc Reviewer, Cardiovascular Research Ad hoc Reviewer, Autonomic Neuroscience: Basic and Clinical

Ad hoc Reviewer, Journal of Neuroscience Ad hoc Reviewer, Molecular & Cellular Endocrinology Ad hoc Reviewer, Journal of Physiology (Lond.)

Reviewer, Somatosensory and Chemosensory Systems; NIH Reviewer, P20 Developmental Grants in benign Urology, NIDDK

Reviewer, NIDDK Nociceptor Genito-Urinary Molecular Anatomy Project (nGUDMAP) (Co-Chair)

Associate Editor, 2011-present, Autonomic Neuroscience: Basic and Clinical Guest Editor, 2013-2015, Autonomic Neuroscience: Basic and Clinical, Special

Issue: Estrogen and the autonomic nervous system

Teaching Activities: PHSL 846 – Advanced Neuroscience 4 hours lecture

PHSL 830 – Cardiovascular Physiology CORE 815 – Cardiopulmonary 3 hour lecture COPD Small Group 4 hours

Trainees: Anuradha Chakrabarty, Ph.D. Senior Scientist, AT2 in pain and axon sprouting

Sarah Tague, PhD, Senior Scientist, Role of vitamin D in joint pain Aritra Bhattacherjee, PhD, Post-doctoral fellow, Sensory disorders in Rett

syndrome Dora Krizsan-Agbas, PhD, Senior Scientist, Stem cell repair in spinal cord injury Zhaohui liao, MD, Research associate, Hormone and reproductive tract

innervation Ying Mu, MS, Research Associate, Expression of AT2 in sensory neuronal cell

lines

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John A. Stanford, Ph.D., Associate Professor My research is focused on preclinical models of normal aging and age-related diseases and conditions that affect motor function, such as Parkinson’s disease (PD), Amyotrophic Lateral Sclerosis (ALS) and neonatal hyperbilirubinemia (kernicterus). We are currently examining the effects of a high fat diet-induced on neurological function in attempts to understand the co-morbidity between Type 2 Diabetes and age-related diseases such as PD and Alzheimer’s disease (AD). We are also studying the effects of isometric strength training on neuromuscular denervation in the SOD1-G93A rat model of ALS. Our most recent studies involve characterizing behavioral and neurological abnormalities in the Gunn rat model of kernicterus. Meetings Attended:

May 2, 2015 – “Effects of Tongue Force Training on Bulbar Motor Function in Female SOD1-G93A Rats.” 22nd Annual Meeting of the American Society for Neural Therapy and Repair, Clearwater Beach, FL

Committee Activities: Departmental

Member, Graduate Student Committee Member Jason Flor-Sistante, Ph.D. Matthew Stroh, Ph.D. Sidrah Sheik, KCUMB College of Biosciences II year Research

track program Sha Neisha Williams, KCUMB College of Biosciences II year

Research track program Coordinator, Seminar Series Member, Finance Committee KUMC Member, Rodent Behavior Advisory Committee Member, KUMC Neuroscience Graduate Program Advisory Committee Member, KIDDRC Core B Advisory Committee

Member, Society for Neuroscience Kansas City Chapter Executive Committee

Co-President, Society for Neuroscience Kansas City Chapter Member, Kansas Board of Regents KUMC Program Review for Dept. of

Anatomy & Cell Biology Member, KUMC IGPBS Admissions Committee (Neuroscience

representative) Program Director, KUMC Biomedical Research Training Program Campus Coordinator, K-INBRE Associate Director and KUMC Editorial and Grant Reviews: Reviewer, Annals of Biomedical Engineering Reviewer, Behavioral Pharmacology Reviewer, Experimental Neurology

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Dr. Stanford (continued) Editorials and Grant Reviews (continued)

Ad hoc Reviewer, Journal of Alzheimer’s Disease Ad hoc Reviewer, Acta Biochemica et Biophysica Sinica Ad hoc Reviewer, Psychopharmacology Ad hoc Reviewer, Neurobiology of Disease Ad hoc Reviewer, Journal of Applied Physiology Ad hoc Reviewer, British Journal of Pharmacology

Ad hoc Reviewer, Cell Death & Disease Ad hoc Reviewer, Pharmacology, Biochemistry & Behavior Ad hoc Reviewer, Neurotoxicity Research

Ad hoc Grant Reviewer, Parkinson’s UK Ad hoc Grant Reviewer, Research Grants Council (Hong Kong)

Ad hoc Grant Reviewer, Wellcome Trust

Seminars Presented: August 15, 2014 – “Translatable Measures of Motor Function and Strength

Training in Preclinical Models of Parkinson’s Disease and ALS.” Science Friday Seminar Series, Kansas City University of Medicine and Biosciences, Kansas City, MO

March 4, 2015 – “Translatable Measures of Motor Function and Strength Training in Preclinical Models of Parkinson’s Disease and ALS.” Department of Chemistry Seminar Series, Wichita State University, Wichita

April 27, 2015 – “Neuromuscular Effects of Targeted Strength Training in the SOD1-G93A Rat Model of ALS.” Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS

Teaching Activities: CORE 840 – Brain and Behavior. PHSL 846 – Advanced Neuroscience Course Director 20 hours classroom teaching

PHSL 848 – Molecular Mechanisms of Neurological Disorders 6 hours classroom teaching Trainees: Delin Ma, MD – Visiting Scholar: Preclinical Studies of Kernicterus

Lily Gan, MD – Visiting Scholar: Preclinical Studies of Amyotrophic Lateral Sclerosis

Aishwarya Kumar – Undergraduate Student: Preclinical Studies of Amyotrophic Lateral Sclerosis

Cameron Banning – Undergraduate Student: Preclinical Studies of Amyotrophic Lateral Sclerosis

Bethany Snyder – High School Student: Preclinical Studies of Amyotrophic Lateral Sclerosis

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Dharmalingam Subramaniam, Ph.D., Research Assistant Professor My research is focused on gastrin mediated carcinogenesis and chemoprevention.

a) Gastrin mediated carcinogenesis is to determine the response of gastric epithelial cells to gastrin, a small peptide hormone and also infection by Helicobacter pylori, which are gram negative, microaerophlic, spiral shaped bacilli. Infection with Helicobacter pylori results in hypergastrenemia and gastric cancer. In this area is to determine the different gastrin induced cellular signaling response in gastric and colon epithelial cells and its subsequent effects on the expression of proinflammatory gene COX-2 and IL-8 expression at the transcriptional and posttranscriptional levels.

b) Chemoprevention, to determine the signaling mechanisms of dietary phyto-

chemicals & their analogues, and chemotherapeutic agents against colon and pancreatic cancer.

Meetings Attended: April 18-22, 2015 – 106th American Association of Cancer Research

Annual meeting, Philadelphia, PA Committee Activities: National

Participant, Thomas O Saliva Foundation Golf Tournament; Colon cancer awareness

Participant, 2015 Rod Rogers Memorial Golf Tournament; Pancreatic cancer awareness

Editorial and Grant Reviews:

Reviewer, KUCC Cancer Center pilot projects Ad hoc Reviewer, PlosOne-4 Ad hoc Reviewer, European Journal for Clinical Investigation-1 Ad hoc Reviewer, Molecular Carcinogensis-2 Ad hoc Reviewer, International Journal of Biological Sciences-1 Ad hoc Reviewer, Evidenced based Complementary and Alternative Medicine-2 Editorial Board Member, Indian Journal of Applied Microbiology Seminars Presented:

February 4, 2015 – “Clostridium difficile infection induces NF-kB in intestinal epithelial cells: suppressing inflammatory response by curcumin.” University of Madras, Chennai, India

February 12, 2015 – “Repurposing Strategies for Pancreatic Cancer: Focusing

on an Old Antibiotic.” Abedha Inamdhar College, University of Pune, India

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Dr. Subramaniam (continued) Trainees: Afreen Sayed, Graduate student

Zainab Afsal, Rotation student Julia Balmaceda, Summer student Parasarathy Rangarajan, Post-doctoral Fellow: Effect of Cyclopirox on Bladder

Cancer Deep Kwatra, Post-doctoral Fellow: Bitter melon and its component Charantin on

colon cancer therapy Gaurav FNU, Post-doctoral Fellow: Honokiol effect on Melanoma Prasad Dandawate- Postdoctoral Fellow: Jak2 and Stat3signling pathway on

pancreatic cancer Sivapriya Ponnurangam, Research Associate David Standing, Research Technician Dr. Aravind Sugmar, MD, junior faculty member: Effect of Gedunin and its analog

on pancreatic cancer Dr. Seth Septer, MD, junior faculty member –Children Mercy Hospital: FAP,

Colon Cancer Prevention and therapy Dr. Pablo Angulo, DO, Fellow in Children Mercy Hospital: Osteosarcoma –

therapy Academic Honors:

April 2015 – Kansas University Cancer Center Travel Award for the abstract entitled “Quinomycin A affects pancreatic cancer stem cells in part through suppression of Notch Signaling Pathway”. Poster presentation. 106thAmerican Association of Cancer Research Annual meeting, Philadelphia, PA

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Joseph S. Tash, Ph.D., Professor My research is funded both by NIH and by NASA. My NIH-funded research focuses on reproductive biology and the regulation of sperm motility and sperm function, and identification of testis and/or sperm specific functional components that can be targeted for development of reversible non-hormonal male contraceptive agents. My ongoing NIH grant effort is focusing on continued drug development and elucidating the mechanism of action of H2-gamendazole (H2-GMZ), an 100% effective and 100% reversible orally-active, highly-potent anti-spermatogenic contraceptive agent. The project is also discovering alternative chemical scaffold lead agents that target the same Sertoli cell molecular targets as H2-GMZ. We recently met with the FDA to establish the first ever guidance for a non-hormonal male contraceptive that established the testing necessary to enable registering H2-GMZ as an IND and to ultimately enable first-in human clinical trials. With regard to gravitational research, I have been funded by NASA since 1996 and examining the effects of space flight on both male and female reproductive health. I have had 5 flight experiments on the Space Shuttle from 1997-2011, including three of the last five shuttle flights). We recently completed a successful flight experiment in May, 2013 on a Russian BION satellite that was the largest and longest animal space flight experiment in NASA and Russian Space Agency history. We are examining the effects of 30 days of space flight, including continuous exposure to microgravity and space radiation, on testis function and sperm health in adult male mice. A new NASA grant scheduled to begin funding in Aug 2013, will be the first ever flight of mammalian and sea urchin sperm to the International Space Station National Laboratory to study the impact of space flight on sperm motility, metabolomics and signal transduction. Meetings Attended:

October 18-22, 2014 – American Society for Reproductive Medicine. Minisymposium speaker, Honolulu, HI

October 22-26, 2014 – American Society for Gravitational and Space Research. Conference Program Chair and Speaker, Pasadena, CA

October 26-27, 2014 – NICHD Contraceptive Discovery and Development Branch Steering Committee Meeting, Speaker, NIH, Besthesda, MD

October 29, 2014 – Illumina Next-Generation Sequencing Pilot Research Symposium, KUMC, Kansas City, KS

Committee Activities: National Member, NICHD Contraceptive Discovery and Development Branch

(CDDB) Steering Committee Member, Board of Governors, American Society for Gravitational and

Space Biology

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Dr. Tash (continued) Editorial and Grant Reviews:

Reviewer, U01 Male Contraceptive Discovery and Development Program,

Special Emphasis Panel

Seminars Presented: October 29, 2014 – “Next Generations Sequencing Reveals That 30 Days of

Space Flight Induces Major Changes in Gene Expression and Spermatogenic-Maintenance Networks in Testis of Adult Male Mice.” KUMC Illumina Next-Generation Sequencing Pilot Research Symposium, Kansas City, KS

Teaching Activities:

CORE 830 – Reproduction and Sexuality. Lecture “Prospects for Male Contraception” to first year medical students

Trainees:

Lesya Holets, Ph.D., Post-doc, Cell-cycle regulatory kinases as targets for male contraceptive drug development., H2-Gamendazole analogues as reversible non-hormonal male contraceptive agents

Uma Sharma, M.S., Research Assistant, Cell-cycle regulatory kinases as targets for male contraceptive drug development

Erica Okwuazi, Research Technician, Space flight-altered motility activation and fertility-dependent responses in sperm from sea urchin and rodents

Eric Yarns, Research Assistant, Space flight-altered motility activation and fertility-dependent responses in sperm from sea urchin and rodents, Female reproductive health: Space flight induced ovarian & estrogen signaling dysfunction, adaptation, and recovery

Other Activities:

Consultant to Techshot, for development of snap-freeze hardware/facility for genomic/molecular research on the International Space Station

Academic Honors:

Approved for 6 month Sabbatical, including a 4 month collaboration at the Oregon National Primate Research Center, Oregon Health Science University (with Dr. Mary Zelinski)

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John P. Thyfault, Ph.D., FACSM, Associate Professor Chronic physical inactivity, sedentary behavior, and low aerobic fitness are linked to the development of chronic disease conditions including obesity, insulin resistance, fatty liver disease, type 2 diabetes, and cardiovascular disease. In contrast, daily physical activity and maintenance of aerobic fitness throughout the lifespan are associated with protection against chronic disease(s). The mechanism(s) underlying the development of these diseases and the role that activity and fitness status play in altering susceptibility remain largely unknown and are the focus of our research. We utilize integrative (multi-tissue and whole body), translational (cells, rodents, humans) approaches to perform studies in these areas with a focus on clinical or human relevance. Meetings Attended:

October 23, 2014 – Low aerobic capacity and susceptibility for NAFLD and metabolic

dysfunction. Canadian Society for Exercise Physiology Annual Meeting. St. John’s, Canada

May 30, 2015 – Is inactivity a cause of insulin resistance? Biology / Pathobiology of

Inactivity: A Symposium Honoring Dr. Charles M. Tipton. American College of Sports Medicine, San Diego CA

Jun 6, 2015 – Effects of Exercise and Aerobic Capacity on the Liver. Symposium title:

Effects of Exercise on Non-muscle Targets. American Diabetes Association Annual Meeting, Boston, MA

Committee Activities: National

Member – Program Committee for the Obesity Society Annual Meeting in Los Angeles, CA

Member – Program Committee for the Integrative Biology of Exercise meeting to be held in 2016

Editorial and Grant Reviews: Ad hoc Reviewer, Diabetes Ad hoc Reviewer, AJP Endocrinology Ad hoc Reviewer, Obesity Ad hoc Reviewer, JAMA Ad hoc Reviewer, Medicine and Science in Sports and Exercise

Reviewer, NIH-NIDDK-Integrative Physiology of Obesity and Diabetes (IPOD) Study Section- February 2015

Reviewer, NIH-ZRG1 EMNR-Q-Nutrigenetics and Nutrigenomics- July 2015 Editorial Board Reviewer, Applied Physiology Nutrition and Metabolism Editorial Board Reviewer, Experimental Physiology

Seminars Presented: April 2015 – Aerobic fitness, mitochondrial dysfunction and susceptibility for NAFLD, St.

Louis University, St. Louis, MO

108

Trainees: Colin McCoin, Ph.D. – Post-Doctoral Fellow: Regulation of hepatic mitophagy E. Matthew Morris, Ph.D. – Post-Doctoral Fellow: Mitochondrial dysfunction in

hepatic steatosis Julia Allen – Lab Manager

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Shahid Umar, Ph.D., Associate Professor Research in my laboratory is focused on the role of bacterial infection in colonic crypt hyperplasia and/or inflammation and cancer. Specific research areas include: (a)

Epigenetic regulation of cross-talk between components of the Wnt/-catenin and Notch

and NF-B and Notch pathways in relation to complex inter-relationship amongst cell proliferation, inflammation and cancer; (b) Cancer Stem Cells, (c) miRNAs, (d) EMT and (e) mechanism(s) of chemoprevention by dietary factors and its novel derivatives. Meetings Attended: February 10-12, 2015 - Invited Speaker, 2nd International Conference on Herbal and Synthetic Drug Studies (HSDS – 2014), Interdisciplinary Science and Technology Research Academy, Pune, India. Committee Activities:

KUMC Member, Faculty Development Committee Member, Institutional Animal Care and Use Committee (IACUC)

Graduate Student Committee Member: External Advisor External Advisor, Carla Kantara Ph.D. Neurosciences and Cell Biology External Advisor, Weijuan Wu Ph.D. Physiology

Editorial and Grant Reviews: Ad hoc Reviewer, American Journal of Physiology Ad hoc Reviewer, Biochemical Pharmacology Ad hoc Reviewer, Biomed Central Ad hoc Reviewer, Cancer Biology and Therapy Ad hoc Reviewer, Carcinogenesis Ad hoc Reviewer, Digestive Diseases and Sciences Ad hoc Reviewer, FEBS Letters Ad hoc Reviewer, Molecular Carcinogenesis

Ad hoc Reviewer, Oncogene Ad hoc Reviewer, PLoS One Ad hoc Reviewer, The Journal of Pathology Editorial Board Member, World Journal of Clinical Oncology Reviewer, NIDDK’s Fellowship in Digestive Diseases and Nutrition Reviewer, NIH-Patterns of Interaction in Peer Review meetings Reviewer, NCCAM’s Special Emphasis Panel Seminars Presented:

May 4, 2015 – “Enteric pathogens and disease pathogenesis.” Department of Molecular and Integrative Physiology, Seminar Series, University of Kansas Medical Center, Kansas City, KS

May 4, 2015 – Host, “microbe interactions: Intestinal response to injury.” Division of Hematology and Oncology’s Head and Neck Cancer residents, University of Kansas Medical Center, Kansas City, KS

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Dr. Umar (continued) Teaching Activities: GSMC 851 - Molecular Genetics (IGPBS) 3 – 2 hour lectures PHSL 842- Comprehensive Human Physiology 3-2 hour lectures Trainees:

Ishfaq Ahmed, Ph.D. – Post-Doctoral Fellow Badal Roy, Ph.D. – Post-Doctoral Fellow Nikhit Chimalakonda – Volunteer Manahil Khan – Volunteer Academic Honors:

Invitation for Leading Theme Series – American Journal of Physiology: Gastrointestinal and Liver Physiology: ‘Chemoprevention in Gastrointestinal Physiology and Disease. Natural products and microbiome’, 307: G1-G14, 2014. Editor’s Pick: American Journal of Physiology: Gastrointestinal and Liver Physiology: ‘Natural products and microbiome’ May 30th, 2014. Bacteria Lurking in your colon can influence cancer growth. University of Kansas

Cancer Center-Cancer Communications- June, 2015. Microbiome: Microbial mystery: Nature 521, S10-S11(14 May 2015) doi:

10.1038/521S10a. Special Invitation for Freelance Interview.

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Michael W. Wolfe, Ph.D., Associate Professor Summary of Research: Proper regulation of the hypothalamic-pituitary-gonadal axis as well as development and regulation of the placenta are essential to mammalian reproduction. Research in my laboratory is directed towards understanding the cellular and molecular mechanisms involved in regulating the genes encoding the hormones within these tissues. An area of interest is how gonadotropin-releasing hormone secreted by hypothalamic neurons signals to the pituitary to induce the expression of the gonadotropin genes and also how gonadal steroids feedback to regulate the hypothalamus and pituitary. A second area focuses on elucidating the events associated with the differentiation and function of placental trophoblast cells. Our overall goal is to identify the physiologically relevant molecular and cellular events responsible for regulating cell differentiation and tissue/organ function. This will provide a better understanding of how the reproductive system is normally regulated and ultimately, will provide clues as to how diseases, drugs and the environment impact reproductive success. Meetings Attended:

January 2015 – Institute for Reproductive Health and Regenerative Medicine graduate students and post-doctoral fellows. Gave a presentation on “Responsible Conduct of Research: Documentation, Storage, and presentation.”

Committee Activities: Departmental Member, Dissertation Committee for Jessica Foster, M.S. candidate

Member, Dissertation Committee for Bhaswati Bhattacharya, M.S. candidate Chair, Comprehensive Exam for Asona Lui, M.D./Ph.D. candidate Chair, Comprehensive Exam for Margaret Pruitt, M.D./Ph.D. candidate Chair, Comprehensive Exam for Ashley Ward, Ph.D. candidate Chair, Comprehensive Exam for Zelha Nil, Ph.D. candidate Member, Dissertation Committee for Jessica Johnson-Venugopal, Ph.D.

candidate Member, Dissertation Committee for Eric Young, M.D./Ph.D.

candidate Chair, Graduate Student Advisory Committee Director, Graduate Education

KUMC Officer, KUMC Research Integrity Member, KUMC Graduate Council Member, IGPBS Advisory Board Chair, Manuscript dispute resolution committee (appointed by Dr. Peter Smith) Member, Phase I committee for Medical curriculum Chair, Phase I committee – Musculo-Skeletal module review committee

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Dr. Wolfe (continued) Seminars Presented:

May 2014 – “Gonadal regulation of growth and metabolism is ESR1-dependent in rats,” Department of Molecular and Integrative Physiology, KUMC

Teaching Activities: Introduction to Research Ethics (GSMC 856) 12 hours lecture/group discussion

Comprehensive Human Physiology (PHSL 842) 10 hours lecture

Renal-Endocrine Module (CORE 825) 14 hours lecture ~2 hours histopath labs ~4 hours PBL

Reproduction and Sexuality Module (CORE 830) 3 hours lecture

Remediation of Renal-Endocrine Module (CORE 825) Module Director 2 – 2hour review session Trainees:

Anamika Ratri, Graduate student Dr. Soma Paul Shaon Borosha, Volunteer Dr. Mina Moussavi, Volunteer – Instructor at University of Central Missouri

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John G. Wood, Ph.D., Associate Professor Microvascular inflammation occurs in a variety of clinical settings and is a significant contributor to patient mortality in these situations. I am working with faculty and residents in the Department of Surgery to study mechanisms involved in microvascular injury following burns as well as hemorrhagic shock/resuscitation. I also collaborated with Dr. Janet Pierce on a project examining the effect of coenzyme Q10, an antioxidant, on inflammation during shock/resuscitation. Meetings Attended

October 26-30, 2014 – Hogan J, Wood JG. Howard J, and Moncure M. Microvascular Acclimatization to Chronic Hypoxia Attenuates Microvascular Hyperpermeability Following Hemorrhagic Shock/Resuscitation via iNOS. Surgical Forum, Oral presentation, San Francisco, CA

March 29- April 1, 2015 – Howard J, Lucero R, Moncure M, Holloway N, and Wood JG. Cutaneous Thermal Injury Increases Leukocyte Adherence in Rat Mesenteric Venules by a Reactive Oxidant-Dependent Mechanism. FASEB J, poster presentation, Boston, MA

Committee Activities: Departmental Member, Blake Ebner Thesis Committee Member, James Weemhoff Thesis Committee Member, Brianna Holt Thesis Committee Member, Jessica Venugopal Thesis Committee Member, Amy Cantilena Thesis Committee Member, Yuchao Xie Thesis Committee KUMC Member, Academic and Professionalism Committee

Vice-Chair, Promotions SubCommittee Member, Prematriculation planning committee Member, Delp Academic Society Member, Medical student applicant interviews Member, Institutional Animal Care and Use Committee Member, Phase I Committee Member, Committee for Systematic Review of the Blood & Lymph Module Chair, Dept. of Surgery Research Committee Chair, Dept. of Surgery Research Strategic Planning Committee Member, Dept. of Surgery Resident Education Committee Member, Content Experts Committee Member, Readiness for Change Committee Member, Education Council Member, ACE Foundational Science Workgroup

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Dr. Wood (continued) Teaching Activities: First Year Medical Curriculum – Cardiopulmonary Module Module Director 21.5 hours lecture 4 hours small group discussion facilitator 8 hours simulation sessions 5 hours case presentations facilitator Pre-Matriculation Program Course Director 14.5 hours lecture 2 hours small group discussion facilitator 4 hours case presentation facilitator Integration and Consolidation 3 hours lecture PHSL 842 – Comprehensive Human Physiology 13 hours lecture PTOX 887 4 hours lecture Trainees:

Naomi Holloway, Research Associate Jessica Hogan, MD, Resident in Dept of Surgery Melissa Krystel-Whittemore, Third year medical student Nicholas Duethman, Third year medical student Colton Nielson, Third year medical student

Academic Honors: Above and Beyond Award from First Year Medical Students

Second Year Outstanding Lecturer Cardiopulmonary: First Year Outstanding Medical Module