Department of Pharmacology and Biochemistry Courses...

Department of Pharmacology and Biochemistry

Courses Specifications

2017-2018

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Contents

Medical and Pharmacy Terminology ..................................................................................... 2

Anatomy and Histology ........................................................................................................... 6

Physiology ............................................................................................................................... 12

Pharmacology-1 ...................................................................................................................... 16

Pharmacology-2 ...................................................................................................................... 22

Toxicology ............................................................................................................................... 28

Biostatistics ............................................................................................................................. 32

OTC abuse .............................................................................................................................. 36

General Biology ...................................................................................................................... 40

Biochemistry-1 ........................................................................................................................ 44

Biochemistry-2 ........................................................................................................................ 50

Clinical Biochemistry ............................................................................................................. 56

Pharmacogenomics ................................................................................................................. 62

Clinical toxicology .................................................................................................................. 65

Veterinary pharmacy ............................................................................................................. 68

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Delta University for Science and Technology

Quality Assurance Center

Course Specifications

1. Basic Information:

Course Title: Medical and Pharmacy Terminology

Course Code: PB 102

Program on which the course is given: B. Pharm.

Department offering the course: Pharmacology & Biochemistry

Academic year/ level: Spring Semester 2017/2018 Level 1

Prerequisite: None

Credit hours: Lecture: 1 Practical: 0 Total: 1

2. Course Aims:

Learn and recognize common medical and pharmaceutical terms and gain basic understanding

of healthcare language. Acquire the knowledge needed for reading health reports in order to

communicate well with other health-care providers.

3. Intended Learning Outcomes (ILOs):

a. Knowledge and understanding:

At the end of this course, student should be able to:

A1 a1. Identify basic terms in pharmacy that are relevant to orienting students to

pharmacy.

A22

a2. Recognize the proper pharmaceutical and medical terminology,

abbreviations, and symbols related to the central nervous system CNS).

a3.

Define and use prefixes, suffixes, and combining forms that facilitate the

ability to translate medical terms regarding cardiovascular system (CVS) and

gastrointestinal tract (GIT).

a4. Illustrate different forms of writing that help to produce a readable piece of

scientific essay with minimal, or no, language mistakes.

a5. Explain how medical terminology is relevant to communicate with other

health care providers.

b. Intellectual Skills:


B21

b1 Predict the meaning of different medical terms regarding CNS

b2 Differentiate between different medical terms and abbreviations related to

CVS

b3 Classify parts of medical term relevant to GIT

b4

Generate well organized translations of selected medical English extracts

from the reading and comprehension passages into Arabic with special focus

on terminology.

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c. Professional and Practical Skills:


C1

c1. Apply gained knowledge to analyze parts of medical terms in other basic and

clinical sciences.

c2. Create and analyze authentic materials and discuss issues presented in the

scientific literature.

c3. Utilize acquired information for interpretation of terms and abbreviations in

pharmacy.

c4. Manipulate and interact correctly with other healthcare providers.

d. General and Transferable Skills:


D1 d1. Communicate effectively in a scientific language.

D5 d2. Use information technology tools to retrieve information and use on-line

data base related to medical and pharmaceutical abbreviations.

4. Contents:

4.1.Lectures:

4.2. Practical: Not applicable

5. Teaching and Learning Methods:

5.1. Lectures

5.2. Group discussions

5.3. Assignments and self-learning

Study

week Topics

No. of

Credit Hours

1. Introduction (basic word parts, combining vowel rules ,word

building and interpreting medical terms 1

2. Basic word structure (Prefixes) 1

3. Basic word structure (Suffixes) 1

4. Roots of CNS + (Quiz 1) 1

5. Terminology of CNS 1

6. Roots of CVS 1

7. Terminology of CVS 1

8. (Quiz 2)

9. Roots of GIT 1

10. Terminology of GIT 1

11. Medical abbreviations. 1

12. Medical Reports 1

13. Exercise 1

14. Final Exam

Total:

1 credit hour 15.

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6. Student Assessment Methods:

6.1. Assessment methods:

1. Written exam To assess knowledge, understanding, intellectual and professional

skills.

2. Course work To assess knowledge, understanding, intellectual skills, general&

transferable skills.

3. Quizzes To assess knowledge, understanding and intellectual skills.

6.2. Assessment schedule:

Assessment 1 Quiz 1 4thweek


Assessment 3 Assignment all over the term

Assessment 4 Written exam 14th&15thweeks

6.3. Weighing of Assessments:

1. Course work:

- Quiz 1 10

- Quiz 2 10

- Activity (assignments) 5

2. Final-Term Exam 75

Total 100%

7. List of References:

No. References Type

1. Medical Terminology for Health Care Professionals by Jane Rice.

(Pearson; 8thedition, 2014) Textbook

2. USA Journal of pharmacy Education, Electronic Journal Periodical

3. https://www.online-medical-dictionary.org/ Website

8. Matrix of course contents versus ILOs:

a. Lectures:

Study

week Course Contents

ILOs

K&U IS P&PS G&TS

1.

Introduction (basic word parts,

combining vowel rules ,word building

and interpreting medical terms

a1 b4 c1 --

2. Basic word structure (Prefixes) a1 b4 c1 --

3. Basic word structure (Suffixes) a1 b4 c1 --

4. Roots of CNS a2 b1, b4 c1,c2 --

https://www.online-medical-dictionary.org/

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5. Terminology of CNS a2 b1, b4 c1,c2 --

6. Roots of CVS a3 b2, b4 c1,c2 --

7. Terminology of CVS a3 b2, b4 c1,c2 --

9. Roots of GIT a3 b3, b4 c1,c2 --

10. Terminology of GIT a3 b3, b4 c1,c2 --

11. Medical abbreviations. a4, a5 b4 c3,c4 d1, d2

12. Medical Reports a4, a5 b4 c4 d1, d2

13. Exercise a4, a5 b4 c4 d1, d2

Name Signature

Course Coordinator: Dr. Eman Mahmoud

Head of Department: Prof. Dr. Hassn Elkashef

Approval Date 6/2/2018

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Course Title: Anatomy and Histology

Course Code: PB 203


Department offering the course: Pharmacology and Biochemistry

Academic year/ level: Fall Semester 2017/2018 Level 2

Prerequisite: General biology (PB 101)


2. Course Aims:

To provide knowledge and understanding of the basic anatomical structure of different body

systems such as digestive, respiratory, cardiovascular, urinary and nervous systems and the

correlation between their functions and anatomical structure. To introduce theoretical and

practical knowledge of the normal structure of different cells and tissues of the human body

by means of light and electron microscope as well as different histological tools and

techniques for preparation of histological sections.




A1

a1 Explain the basic anatomical structure of the different systems of the body

and its correlation to function.

a2. Define and describe the histological characteristics of normal cells,

cytoplasmic components, membranous and non-membranous cell organelles.

a3. Mention the characteristics of the four basic tissues of human body.

a4. Describe and compare between different blood elements and their

development.



B2 b1. Develop good laboratory practice in histological practical work

B18

b2. Compare the different anatomical structure of organs in the human body

b3. Select appropriate methods to reveal specific microscopic features of cells

and tissues

b4. Discriminate slides of different organs or tissues obtained from different

sources.

b5. Interpret basic results in a complete blood count report

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C1 c1. Utilize the proper histological and anatomical terminology to report and

describe histopathological differences in tissue sections

C5

c2. Differentiate between different cell organelles

c3. Assess the differences between different types of epithelium, connective

tissue cells and bone cells

c4. Use the microscope to distinguish different blood cells in blood films

c5. Identify different types of tissues and organs and to differentiate between

surface markings



D1 d1. Enhance the communication skills through communication with colleagues

during preparing, essays and assignments.

D3 d2. Express themselves freely and work effectively within a team frame.

D6 d3. Develop the skills required for continued self-learning

4. Contents:

4.1.Lectures:

Study

week Topics

No. of

Credit Hours

1. Cytology: structure of cytoplasmic organelles and the nucleus 2

2. Epithelial tissue: simple, stratified, neuron and glandular

epithelium 2

3. Connective tissue fibers, cells and types 2

4. Cartilage: structure and different types of cartilage + (quiz 1) 2

5.

Bone: cell types and ossification-anatomy

Bone: cell types and ossification-histology

2

6.

Cardiovascular system and respiratory system-anatomy

Muscular tissue: skeletal muscles, smooth muscles and

cardiac muscles-histology

2

7. Nervous tissue: neuron, neuroglial cells and autonomic

ganglia 2

8. Quiz 2

9. Blood elements, arteries and veins. 2

10.

Lymphatic system: spleen, thymus and lymph nodes-anatomy

Lymphatic system: spleen, thymus and lymph nodes-

histology

2

11.

Digestive system especially liver and pancreas-anatomy

Digestive system especially liver and pancreas-histology

2

12. Urinary and genital systems –anatomy + revision 2

13. Urinary and genital systems-histology + revision 2

14. Final Exam

Total:

2 credit hours 15.

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4.2. Practical:

Study

week Topics

No. of

Credit Hours

1. Epithelial tissue: simple, stratified, neuronal and glandular

epithelium 1

2. Epithelial tissue: simple, stratified, neuronal and glandular

epithelium (revision) 1

3. Connective tissue fibers, cells and types 1

4. Connective tissue fibers, cells and types (revision) 1

5. Cartilage: structure and different types of cartilage 1

6. Cartilage: structure and different types of cartilage (revision) 1

7. Bone: cell types and ossification. 1

8. Quiz 2

9. Bone: cell types and ossification. (revision) 1

10. Muscular tissue: skeletal muscles, smooth muscles and cardiac

muscles. 1

11. Muscular tissue: skeletal muscles, smooth muscles and cardiac

muscles. (revision) 1

12. Revision 1

13. Practical Exam 1

14. Final Exam

Total:

1 credit hour 15.

5. Teaching and Learning methods:

5.1. Lectures

5.2. Practical classes

5.3. L.M.S

5.4. Group discussion

5.5. Assignment, activity (homework)


6.1.Assessment methods:


skills.

2. Practical exam To assess professional and practical skills.

3. Course work To assess knowledge, understanding, intellectual skills, general &



6.2.Assessment schedule:

Assessment 1 Quiz 1 4th week


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Assessment 3 Assignment/activity

(histology drawing notebook) all over the term

Assessment 4 Practical exam 13th week

Assessment 5 Written exam 14th & 15th weeks

6.3.Weighing of Assessments:

1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity

(histology drawing notebook) 5



Total 100%


No. Reference Type

1.

-Junqueira's basic histology: Text and Atlas, by Anthony Mescher

(McGraw-Hill Education/Medical; 13th edition, 2013)

-Ross and Wilson Anatomy and Physiology in Health and Illness by

Anne Waugh and Allison Grant (Churchill Livingstone; 12th edition,

2014)

Textbook


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Cytology: structure of cytoplasmic

organelles and the nucleus a2 b3 c1, c2 --

2. Epithelial tissue: simple, stratified,

neuron and glandular epithelium a3

b1 , b3,

b4 c1, c3 --

3. Connective tissue fibers, cells and types a3, a4 b2 , b3,

b4 c1, c3 --

4. Cartilage: structure and different types

of cartilage a3, a4

b2 , b3,

b4 c1, c3 d1, d3

5.

Bone: cell types and ossification-

anatomy

Bone: cell types and ossification-

histology

a1, a2,

a3 b2, b4

c1, c3,

c5 d1, d3

https://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&text=Anthony+Mescher&search-alias=books&field-author=Anthony+Mescher&sort=relevancerank

https://www.amazon.co.uk/s/ref=dp_byline_sr_book_1?ie=UTF8&text=Anne+Waugh+BSc%28Hons%29++MSc++CertEd++SRN++RNT++FHEA&search-alias=books-uk&field-author=Anne+Waugh+BSc%28Hons%29++MSc++CertEd++SRN++RNT++FHEA&sort=relevancerank

https://www.amazon.co.uk/s/ref=dp_byline_sr_book_2?ie=UTF8&text=Allison+Grant+BSc++PhD++RGN&search-alias=books-uk&field-author=Allison+Grant+BSc++PhD++RGN&sort=relevancerank

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6.

Cardiovascular system and respiratory

system-anatomy

Muscular tissue: skeletal muscles,

smooth muscles and cardiac muscles-

histology

a1, a2,

a3 b2, b4

c1, c3,

c5 d1, d3

7. Nervous tissue: neuron, neuroglial cells

and autonomic ganglia a3, a4 b2, b4 c1, c3 d1, d3

9. Blood elements, arteries and veins. a2, a4 b2, b4,

b5 c1, c4 d1, d3

10.

Lymphatic system: spleen, thymus and

lymph nodes-anatomy

Lymphatic system: spleen, thymus and

lymph nodes-histology

a1, a2,

a3, a4

b2, b4,

b5

c1, c4,

c5 d1, d3

11.

Digestive system especially liver and

pancreas-anatomy

Digestive system especially liver and

pancreas-histology

a1, a3,

a4 b2, b4 c1, c5 d1, d3

12. Urinary and genital systems –anatomy a1, a3,

a4 b2, b4 c1, c5 d1, d3

13. Urinary and genital systems-histology

8.2. Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Epithelial tissue: simple, stratified,

neuronal and glandular epithelium a2, a3

b1, b3,

b4 c1, c3 d1, d2

2.

Epithelial tissue: simple, stratified,

neuronal and glandular epithelium

(revision)

a2, a3 b1, b3,

b4 c1, c3 d1, d2

3. Connective tissue fibers, cells and types a2, a3 b1, b3,

b4 c1, c3 d1, d2

4. Connective tissue fibers, cells and types

(revision) a2, a3

b1, b3,

b4 c1, c3 d1, d2


of cartilage a2, a3

b1, b3,

b4 c1, c3

d1, d2,

d3


of cartilage (revision) a2, a3

b1, b3,

b4 c1, c3

d1, d2,

d3

7. Bone: cell types and ossification. a2, a3 b2, b3,

b4 c1, c3

d1, d2,

d3

9. Bone: cell types and ossification.

(revision) a2, a3 b2, b3,

b4 c1, c3

d1, d2,

d3

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10. Muscular tissue: skeletal muscles,

smooth muscles and cardiac muscles.

a1, a3,

a4

b2, b3,

b4 c1, c3

d1, d2,

d3

11.

Muscular tissue: skeletal muscles,

smooth muscles and cardiac muscles.

(revision)

a1, a3,

a4

b1, b2,

b3 c1, c3

d1, d2,

d3

12. Revision

Name Signature

Course Coordinator: Prof. Dr. Sanaa Elsherbiny

Head of Department: Prof. Dr. Hassan Elkashef


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Course Title: Physiology

Course Code: PB 204



Academic year/ level: Fall Semester 2017/2018 Level: 2

Prerequisite: General biology (PB 101)


2. Course Aims:

This course aims to introduce the basic principles of physiology and human body

homeostasis. To provide knowledge and understanding of the normal structure and

functions of the major body systems. Moreover, the course integrates physiological data

and mechanisms with clinical applications.



At the end of this course, students should be able to:

A1 a1. List the functional organization and structure of various body systems and its

relation to function.

A11

a2. Describe the structure and functions of the autonomic nervous system, its

higher centers, autonomic receptors and chemical transmitters

a3. Explain the integration between cardiovascular and renal systems to maintain

homeostasis.

a4. Recall the basic functions of endocrine hormones and their effects on

different body systems.

a5.

Describe the functional structure of the respiratory system, the mechanism of

respiratory cycle and some conditions related to disorders of the respiratory

system.

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B18

b1. Integrate the physiological performances of different body system with

overall body homeostasis.

b2.

Assess the general classification of the autonomic nervous system and

compare the function and distribution of sympathetic and parasympathetic

divisions.

b3. Predict the events of the cardiac cycle and the physiological consequences of

factors affecting cardiac output, heart rate and blood pressure.

b4. Classify hormones secreted by endocrine glands and the different functions

of them in the body.

b5. Analyze the physiological roles of gastrointestinal, renal and respiratory

systems in maintaining normal homeostasis.



C5

c1. Apply physiological information to other basic and clinical sciences.

c2. Employ basic physiological measurements to test different body functions.

c3. Manage and diagnose common endocrinal conditions based on data from

clinical lab tests

c4. Apply clinical skills and tools in assessment of body functions in health.



D2 d1. Retrieve physiological information resources.

D3 d2. Work in a team to participate effectively as member of the health care team

D6 d3. Develop the skills required for continued self-learning.

4. Contents:

4.1. Lectures:

Study

week Topics

No. of

Credit Hours

1

Electrophysiological properties & cell membrane

Physiology of autonomic nervous system (parasympathetic

NS)

2

2 Physiology of autonomic nervous system (sympathetic NS) 2

3. Physiology of cardiovascular system (cardiac functions,

properties and cardiac cycle) 2

4. Physiology of cardiovascular system (blood vessels and

blood pressure regulation) + (quiz 1) 2

5 Physiology of endocrine system (adrenal gland) 2

6 Physiology of endocrine system (thyroid and parathyroid

gland) 2

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5.1. Lectures

5.2. L.M.S

5.3. Group assignment

5.4. Discussions of clinical cases




skills.



3.Quizzes To assess knowledge, understanding and intellectual skills.




Assessment 3 Assignment (essay) all over the term

Assessment 4 Written exam 14th &15th weeks


1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment (essay) 5


Total 100%

7 Physiology of endocrine system (anterior and posterior

pituitary gland) 2

8. Quiz 2

9. Physiology of endocrine system (pancreas) 2

10 Physiology of upper gastrointestinal tract 2

11 Physiology of lower gastrointestinal tract 2

12 Physiology of renal system 2

13 Physiology of respiratory tract 2

14. Final Exam

Total:

2 credit hours 15.

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No. Reference type

1.

1.1. Ross and Wilson Anatomy and Physiology in Health

and Illness by Anne Waugh and Allison Grant (Churchill

Livingstone; 12th edition, 2014)

1.2. Hole's Essentials of Anatomy and Physiology by David

Shier, Jackie Butler andRicki Lewis (McGraw-Hill

Education; 12th edition, 2014)

1.3. Ganong's Review of Medical Physiology by Kim E.

Barrett, Susan M. Barman, Scott Boitano and Heddwen L.

Brooks(McGraw-Hill Education; 25th edition, 2015).

textbook

2. https://www.physiology.org & The Journal of Physiology website


8.1.Lectures:

Study


ILOs

K&U IS P&PS G&TS

1-2 Physiology of autonomic nervous

system a1, a2 b1, b2 c1,c2 --

3-4 Physiology of cardiovascular

system a1, a3 b1,b3 c1,c2,c4 d1

5-7 Physiology of endocrine system a1,a4 b1,b4 c3 d1

9. Physiology of endocrine system a1,a4 b1,b4 c3 d1,d2

10-11 Physiology of gastrointestinal

tract a1 b1, b5 c1,c4 d2,d3

12 Physiology of renal system a1, a3 b1, b5 c1,c4 d2,d3

13 Physiology of respiratory system a1,a5 b1, b5 c1,c4 d2,d3

Name Signature

Course Coordinator: Dr. Ahmed Saad

Head of Department: Prof. Dr. Hassan A. Elkashef


https://www.physiology.org/

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Course Title: Pharmacology-1

Course Code: PB 331



Academic year/ level: Fall Semester 2017/2018 Level three

Prerequisite: Physiology (PB 204)


2. Course Aims:

To provide knowledge and understanding of the basic principles of pharmacokinetics and

pharmacodynamics and introduce concepts of drug action with illustration of different

mechanisms to provide comprehensive coverage of the major drug groups affecting different body

systems; autonomic nervous system, cardiovascular system, respiratory system, and autacoids.




A8

a1.

Identify the basic principles of pharmacodynamics, including modes of drug action and

terms related to drug-receptor interaction (efficacy and potency, agonists and

antagonists).

a2 Recognize the fundamental concepts of pharmacokinetics, including absorption,

distribution, metabolism and elimination.

A13

a3. Outline significant indications, adverse effects and interactions of different classes of

autonomic drugs (agonists and antagonists of adrenergic and cholinergic receptors).

a4 Recall basic pharmacological aspects of autacoids, autacoid antagonists and drugs

acting on the respiratory system.

a5

Recognize significant indications, adverse effects and interactions of drugs used in

treatment of cardiovascular diseases (hypertension, angina, heart failure and

arrhythmia).



B9

b1. Predict the pharmacodynamics of different classes of drugs affecting autonomic

nervous system and proper selection in various disease conditions.

b2 Compare the pharmacokinetics and pharmacodynamics of different drugs affecting

respiratory system and proper specification of dosage and dose regimen.

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B11

b3

Differentiate between first, second and third line drugs used in treatment of

hypertension in patients with or without other comorbidities (asthma, diabetes,

chronic kidney disease, …)

b4 Create a therapeutic plan for management of different types of ischemic heart

diseases (angina and myocardial infarction).

b5 Classify types of heart failure and identify the therapeutic modality of each type.



C11

c1 Design an experimental protocol to show the effects of the drugs on

laboratory animals, including mice and rats.

c2 Apply different routes of drug administration and assess the precise skills

regarding calculation of drug doses.

c3 Handle experimental animals as well as different isolated tissue preparations.

C13 c4 Utilize the problem-based learning (PBL) to identify the interactions and

adverse effects of different agonists and antagonists of autonomic receptors.



D2 d1 Retrieve drug information resources.

D3 d2 Work effectively within a team.

D11 d3 Reach appropriate solutions in a case based modules.

4. Contents:

4.1.Lectures:

Study

week Topics

No. of

Credit Hours

1. -Pharmacodynamics

Receptors, efficacy, potency, agonist and antagonists 3

2. -Pharmacokinetics

Absorption, distribution, metabolism & elimination of drugs

3

3. - Introduction to autonomic pharmacology 3

4. - Acetylcholine receptors agonists and antagonists

- Neuromuscular blockers + (Quiz 1)

3

5. - Adrenoceptors activating drugs 3

6. - Adrenoceptors blocking drugs 3

7. Autacoid and autacoid antagonists 3

8. Quiz 2

9. Drugs acting on respiratory system 3

10. Anti-hypertensive drugs 3

11. Anti-anginal drugs 3

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4.2. Practical:

Study

week Topics

No. of

Credit Hours

1. Handling of animals

1

2. Routes of drug administration

1

3. Dose calculation

1

4. Mice handling and injection

1

5. Hypnotics

1

6. PBL

1

7. Revision

1

8. Quiz 2

9. In-vitro experiments

1

10. Effect of acetylcholine on isolated rabbit intestine

1

11. Effect of barium chloride on isolated rabbit intestine

1

12. Effect of acetylcholine and Bacl2 in presence of atropine on

isolated rabbit intestine 1


14. Final Exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Practical session using laboratory equipment and experimental animals

5.3. Group assignment

5.4. Case discussions and PBL

5.5. L.M.S

12. Drugs for treatment of congestive heart failure 3

13. Anti-arrhythmic drugs 3

14. Final Exam

Total:

3 credit hours 15.

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skills.




4. Oral exam To assess knowledge, understanding, intellectual skills, general skills

and confidence.





Assessment 3 Assignment/activity (homework) all over the term


Assessment 5 Written exam weeksth& 15th 14

Assessment 6 Oral exam weeksth& 15th 14


1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (homework) 5

2 Practical Exam 25


3. Oral Exam 10

Total 100%


No. Reference Type

1.

1.1.Rang and Dale Pharmacology by James Ritter, Rod Flower

Graeme Henderson and Humphrey Rang (Churchill Livingstone;

8th edition, 2015).

1.2. Lippincott Illustrated Reviews: Pharmacology by Karen Whalen

(Lippincott Williams & Wilkins; 6th edition, 2015).

1.3. Brody's Human Pharmacology, Molecular to Clinical; by Lynn

Crespo, Lynn Wecker, George Dunaway, Carl Faingold and

Stephanie Watts (Elsevier Mosby; fifth Edition, 2010)

Textbook

https://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&text=Karen+Whalen+PharmD++BCPS&search-alias=books&field-author=Karen+Whalen+PharmD++BCPS&sort=relevancerank

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2.

-British Journal of Pharmacology.

-Pharmacological Reviews.

-Trends in Pharmacological Sciences.

Periodical

3.

www.aspet.org (The American Society for Pharmacology and

Experimental Therapeutics),

www.rxlist.com & www.drugs.com

Website


8.1.Lectures:

Study


ILOs

K&U IS P&PS G&TS

1.

-Pharmacodynamics

Receptors, efficacy, potency, agonist

and antagonists

a1 b1,b2 c1, c4 --

2.

-Pharmacokinetics

Absorption, distribution, metabolism &

elimination of drugs

a2 b2 c2 --

3. Introduction to autonomic

pharmacology a3 b1 c4 d1,d2

4.

- Acetylcholine receptors agonists and

antagonists

- Neuromuscular blockers

a1,a2,a3 b1 c3,c4 d1,d3

5. Adrenoceptors activating drugs a1,a2,a3 b1 c4 d1,d3

6. Adrenoceptors blocking drugs a1,a2,a3 b1 c4 d1,d3

7. Autacoid and autacoid antagonists a1,a2,a4 b2 c4 d1

9. Drugs acting on respiratory system a1,a2,a4 b1,b2 c4 d1,d2, d3

10. Anti-hypertensive drugs a1,a2,a5 b1, b3 c4 d1,d2, d3

11. Anti-anginal drugs a1,a2,a5 b1, b4 c4 d1,d2, d3

12. Drugs for treatment of congestive heart

failure a1,a2,a5 b1, b5 c4 d1,d2, d3

13. Anti-arrhythmic drugs a1,a2,a5 b1, b5 c4 d1,d2, d3

8.2.Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Handling of animals --- b1 c1, c2,c3 --

2. Routes of drug administration a1, a2 b1 c2, c3 --

http://www.aspet.org/

21 | P a g e

3. Dose calculation --- b1 c1 --

4. Mice handling and injection -- -- c1, c2 d1,d2

5. Hypnotics a1, a2 -- c1, c2 d1,d2

6. PBL -- -- c4 d1,d2.d3

7. Revision -- b1 c1, c2 d1,d2.d3

9. In-vitro experiments a3 b1 c3 d2

10. Effect of acetylcholine on isolated

rabbit intestine a3 b1 c3 d2

11. Effect of barium chloride on isolated

rabbit intestine a3 b1 c3 d2

12.

Effect of acetylcholine and Bacl2 in

presence of atropine on isolated rabbit

intestine

a3 b1 c3 d2

Name Signature

Course Coordinator: Prof. Dr. Hassan A. El-Kashef

Head of Department: Prof. Dr. Hassan A. El-Kashef


22 | P a g e





Course Title: Pharmacology-2

Course Code: PB 332



Academic year/ level: Spring semester 2017/2018 Level: 3

Prerequisite: Pharmacology-1 (PB 331)


2. Course Aims:

To provide comprehensive coverage of the major drug groups affecting the central

nervous system and gastrointestinal tract (GIT) together with chemotherapeutic drugs

(antimicrobial and anticancer). To provide knowledge and understanding of the basic

principles of human body control, the activities of endocrine hormones and drug/hormone

therapies of diseases resulting from excess or deficiency of hormones. Moreover, the

adverse effects and toxicity of centrally acting drugs, hormones and chemotherapeutic

drugs are covered.




A11 a1 Recognize the etiologies and pathomechanisms of major diseases affecting

the central nervous system (CNS).

A13

a2 Outline the mechanisms of action, clinical uses and adverse effects of

different drugs acting on CNS

a3 Identify basic pharmacological aspects of drugs used in treatment of

gastrointestinal disorders

A14

a4 Discuss the proper therapeutic uses of drugs/hormones in treatment various

disorders resulting from deficiency or overproduction of hormones.

a5 Recognize the effects and clinical uses of chemotherapeutic drugs and their

toxicities

23 | P a g e



B9

b1. Assess the drug interactions, adverse reactions and misuse of centrally acting

drugs.

b2. Distinguish between the different classes of hormones and their

pharmacological actions.

b3. Justify the use of antibiotics and chemotherapeutic agents in different

diseases and disorders.

b4

Predict the most clinically important drugs for treatment of emesis,

hyperacidity, peptic ulcer, diarrhea and constipation.



C11 c1. Handle different laboratory animals to apply various experimental studies

c2. Screen pharmacological effects of different classes of CNS drugs

C13 c3. Utilize the problem-based learning (PBL) to analyze and solve clinical cases

of endocrine and gastrointestinal disorders.

C21 c4. Monitor side effects and toxicities of chemotherapeutic agents.



D1 d1 Communicate effectively in a scientific language with professionals

D3 d2 Work effectively within a team

D6 d3 Develop the skills required for self-learning

D9 d4 Demonstrate time management ability

4. Contents:

4.1.Lectures:

Study week Topics No. of Credit

hours

1 Sedatives, hypnotics and anxiolytics 3

2 Antipsychotic and antidepressant drugs 3

3 Opioid analgesics and anti-inflammatory drugs 3

4 Antiparkinsonian and antiepileptic drugs + (Quiz 1) 3

5 Pituitary gland hormones 3

6 Adrenal cortex hormones 3

7 Pancreatic and thyroid hormones 3

8 Quiz 2

9 Drugs acting on GIT 3

24 | P a g e

10 Antibacterial drugs (cell wall synthesis inhibitors) 3

11 Antibacterial drugs ( inhibitors of protein and nucleic acid

synthesis) 3

12 Antiviral, antifungal, antiprotozoal and anthelmintic drugs 3

13 Anticancer drugs 3

14.

Final Exam Total:

3 credit hours 15.

4.2.Practical:

Study

week Topics

No. of

Credit Hours

1. CNS depressants (barbiturates) 1

2. CNS depressants (benzodiazepines) 1

3. PBL (endocrine disorders) 1

4. Narcotic analgesics 1

5. Non-narcotic analgesics 1

6. PBL (infective disorders) 1

7. CNS stimulants (strychnine) 1

8. Quiz 2

9. CNS stimulants (caffeine) 1

10. Determination of the onset of action of a local anesthetic using

laboratory frogs 1

11. Identification of unknown solution of a local anesthetic using

laboratory frogs 1

12. Revision 1


14.

Final Exam Total:

1 credit hour 15.

25 | P a g e


5.1. Lectures

5.2. Practical session

5.3. Group assignments, self-learning

5.4. Case discussions and PBL

5.5. L.M.S




skills.





and confidence.





Assessment 3 Assignment/activity (homework) all over the term


Assessment 5 Written exam weeksth& 15th 14

Assessment 6 Oral exam weeksth15 &th 14


1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (homework) 5

2 Practical Exam 25


4. Oral Exam 10

Total 100%

26 | P a g e


No. Reference Type

1.

1.1.Rang and Dale Pharmacology by James Ritter, Rod

Flower Graeme Henderson and Humphrey Rang

(Churchill Livingstone; 8th edition, 2015).

1.2. Lippincott Illustrated Reviews: Pharmacology by Karen

Whalen (Lippincott Williams & Wilkins; 6th edition,

2015).

1.3. Brody's Human Pharmacology, Molecular to Clinical;

by Lynn Crespo, Lynn Wecker, George Dunaway, Carl

Faingold and Stephanie Watts (Elsevier Mosby; fifth

Edition, 2010)

Textbook

2. -British Journal of Pharmacology.

-Pharmacological Reviews.

-Trends in Pharmacological Sciences.

Periodical

3. www.aspet.org (The American Society for Pharmacology

and Experimental Therapeutics),

www.rxlist.com & www.drugs.com

Website


8.1.Lectures:

Study


ILOs

K&U IS P&PS G&TS

1 Sedatives, hypnotics and anxiolytics a1,a2 b1 c1,c2 --

2 Antipsychotic and antidepressant drugs a1,a2 b1 c1,c2 --

3 Opioid analgesics and anti-

inflammatory drugs a1,a2 b1 c1,c2 d1

4. Antiparkinsonian and antiepileptic

drugs a1,a2 b1 c1,c2 d1,d3

5 Pituitary gland hormones a4 b2 c3 d1, d3

6 Adrenal cortex hormones a4 b2 c3 d1, d3

7. Pancreatic and thyroid hormones a4 b2 c3 d1, d3

9. Drugs acting on GIT a3 b4 c3 d1, d3

10 Antibacterial drugs (cell wall synthesis

inhibitors) a5 b3 c4 d1, d3

11 Antibacterial drugs ( inhibitors of

protein and nucleic acid synthesis) a5 b3 c4 d1, d3

12 Antiviral, antifungal, antiprotozoal and

anthelmintic drugs a5 b3 c4 d1, d3

13 Anticancer drugs a5 b3 c4 d1, d3



http://www.aspet.org/

27 | P a g e

8.2. Practical:

Study week Course Contents ILOs

K&U IS P&PS G&TS

1-2 CNS depressants a1,a2 b1 c1,c2 --

3. PBL (endocrine disorders) a3 b2 c3 d1, d2, d3

4-5 Analgesics a1,a2 b3 c1,c2 d2, d4

6. PBL (infective disorders) a4 b3 c4 d1, d2, d3

7. CNS stimulants (strychnine) a1,a2 b1 c1,c2 d2, d4

9. CNS stimulants (caffeine) a1,a2 b1 c1,c2 d1, d2, d3

10

Determination of the onset of

action of a local anesthetic using

laboratory frogs

a1,a2 b1 c1 d2, d4

11

Identification of unknown

solution of a local anesthetic

using laboratory frogs

a1,a2 b1 c1 d2, d4

12. Revision a1,a2 b1 c1,c2 d2, d4

Name Signature

Course Coordinator: Dr. Ghada Samy

Head of Department: Prof. Dr. Hassan A. El-Kashef


28 | P a g e





Course Title: Toxicology

Course Code: PB 421



Academic year/ level: Spring semester 2017/2018 Level four

Prerequisite: Pharmacology 2 (PB 332)


2. Course Aims:

To understand basic principles and different disciplines of toxicology. To gain knowledge

regarding first aid measures, supportive measures, therapeutic interventions, specific antidotes

as well as general guidelines of treatment modalities. To gain knowledge and understanding

of the mechanisms of toxicity and toxicokinetics of different types of pesticides, heavy

metals, toxic gases and irritant toxins. To understand the serious consequences of exposure to

therapeutic drugs, environmental and occupational chemicals and develop approaches for

prevention, diagnosis and treatment of adverse effects.




A1

a1. Identify different fields of toxicology, including occupational, forensic and

environmental toxicology and general principles of poisoning management.

a2.

Describe the mechanisms of toxicity and toxic effects of certain medications

and environmental pollutants and their selective toxicities on specific target

organs.

A16

a3. Recognize different classes of physical and chemical hazards

a4. Outline toxic profile of various drugs and other xenobiotics including

sources, identification, symptoms, management and first aid measures.

a5. Describe the biological effects of exposure to different types of immunotoxic

and carcinogenic agents.

29 | P a g e



B11

b1. Differentiate between different toxic agents regarding their symptoms, mode

of actions as well as the main lines of toxicity management.

b2. Adapt the knowledge of patient stabilization and antidotes in management of

toxicity cases.

b3. Interpret information about hazards of different pollutants, xenobiotic, heavy

metals, irritant substances and solvents.

b4. Evaluate drug interactions and adverse drug reactions.

B15 b5. Analyze and evaluate reports of toxicity cases.



C7 c1. Manage minor illnesses and differentiate from toxicity cases requiring

prompt medical intervention.

C21

c2. Examine toxicity profiles of different xenobiotics and utilize information in

the selection of management protocols.

c3. Measure and analyze risks concerning drug-drug interactions, adverse

reactions and toxicity profiles.

c4. Conduct the safe and effective use of drugs in patients while managing the

toxicity condition.



D3 d1. Communicate and work effectively in a team.

D5 d2. Implement online computer searching to develop information technology

skills from a variety of sources.

D12 d3. Demonstrate rational thinking and decision-making abilities

4. Contents:

4.1.Lectures:

Study

week Topics

No. of

Credit Hours

1. Introduction 2

2. Mechanisms of toxicity 2

3. Target organ toxicity 2

4. Air, soil and water pollution + (quiz 1) 2

5. Metal toxicity 2

6. Liver toxicity 2

7. Hematotoxicity 2

8. Quiz 2

9. Carcinogenesis (stages of carcinogenesis and carcinogens) 2

30 | P a g e


5.1. Lectures

5.2. Seminars

5.3. Group assignments and self-learning activities

5.4. Case study discussion




skills.




and confidence.





Assessment 3 Assignment all over the term


Assessment 5 Oral exam 14th & 15th weeks


1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment 5


3. Oral Exam 10

Total 100%

10. Carcinogenesis (oncogenes and tumor suppressor genes) 2

11. Pulmonary toxicity 2

12. Kidney toxicity + case study 2

13. Immunotoxicity 2

14. Final Exam

Total:

2 credit hours 15.

31 | P a g e


No. Reference Type

1. Casarett & Doull's Toxicology: The Basic Science of Poisons, by

Curtis Klaassen. (McGraw-Hill Education; 8th edition, 2013 Textbook

2. Journal of Toxicological Sciences; Journal of Toxicology and

Applied Pharmacology Periodical

3. TOXNET (https://toxnet.nlm.nih.gov/) Website


8.1. Lectures:

Study

Week Course Contents

ILOs

K&U IS P&PS G&TS

1. Introduction

a1, a2 b1, b2 c1 --

2. Mechanisms of toxicity a2, a3 b1, b3 c1 --

3. Target organ Toxicity

a2, a3 b1,b3 c1, c2 d2,d3

4. Air, soil and water pollution a1, a2,

a3 b1, b3 c3 d2,d3

5. Metal Toxicity

a2, a4 b1, b2, b3 c1, c2,

c4 d1,d2,d3

6. Liver Toxicity

a2, a4 b1, b4 c3,c2,c4 d2,d3

7. Hematotoxicity

a2, a4 b1, b4 c2,c3,c4 d2,d3

9. Carcinogenesis ( stages of

carcinogenesis and carcinogens) a2, a4,

a5 b1, b3 c1, c2,c3 d1,d2

10. Carcinogenesis ( oncogenes and

tumor suppressor genes ) a2, a4,

a5 b1, b3 c1, c2,c3 d1,d2

11. Pulmonary Toxicity

a2, a4 b1, b4 c2,c3,c4 d2,d3

12. Kidney Toxicity + case study

a2, a4 b1, b4, b5 c2,c3,c4 d2,d3

13. Immunotoxicity a2, a4,

a5 b1, b4 c2,c3,c4 d2,d3

Name Signature

Course Coordinator: Dr. Amany Abdelmegid



https://toxnet.nlm.nih.gov/

32 | P a g e





Course Title: Biostatistics

Course Code: PB 542



Academic year/ level: Spring Semester 2017/2018 Level Five

Prerequisite: None


2. Course Aims:

To enhance the student’s ability in problem solving, experimental design, and evaluation of

clinical trials data; as well as, to use statistical methods in collection and presentation of data.

The course provides knowledge about estimation of the drug’s effects on different body

organs and tissues.




A1 a1. Recognize basic concepts of biostatistics and data analysis.

a2. Describe the principles of basic science in the field of biological assay.

A17

a3. Mention methods of statistical analysis and pharmaceutical calculations in an

efficient manner for handling data.

a4. Identify ways of drug screening on experimental animals to determine the

mechanisms of action.

a5. Recall methods of drug bioassay on experimental animals to estimate the

potency of drugs.



B13

b1. Predict role of biostatistics in medical research.

b2. Interpret the meaning of different data presentation types.

b3. Analyze critically the data derived from laboratory and clinical

measurements.

b4. Compare the potency of the test and standard preparations used in bioassay

procedures based on the statistical results.

b5. Assess the main steps in screening and biological standardization of different

substances based on their physiological function or toxic effects.

33 | P a g e



C11

c1. Select appropriate statistical tests and use results of applied statistics to make

informed decisions.

c2. Apply methods of graphical presentation.

c3. Discriminate between various experimental models to select the best one

used for biological assay.

c4. Design complete experimental protocols for biological standardization of

different compounds.



D3 d1. Work effectively within a team.

D4 d2. Collect, evaluate and present data in accordance with standard statistical

methods.

D11 d3. Search the internet for updates of statistical problem-solving methods and

concepts related to the probability, screening and bioassays.

4. Contents:

4.1.Lectures:

Study

week Topics

No. of

Credit Hours

1. Introduction of statistics + strategies to understand the

meaning of data (descriptive statistics) 2

2.

Measures of central tendency (mean, median, mode) +

measures of dispersion (range, variance and standard

deviation)

2

3. Hypothesis testing (one sample t-test) 2

4. Hypothesis testing (Unpaired and paired student t-test) +

Quiz 1 2

5. Hypothesis testing (ANOVA test) and Chi-X2 test 2

6. Correlation, regression, measures of mortality and morbidity

and non-parametric tests. 2

7. Applications (Exercise + PBL) 2

8. Quiz 2

9. Screening and bioassay of autonomic drugs 2

10. Screening and bioassay of skeletal muscle relaxants 2

11. Screening and bioassay of analgesics, anti-inflammatory

drugs and local anesthetics 2

12. Screening and bioassay of insulin and cardiac glycosides 2

13. Screening and bioassay of antihypertensive drugs 2

14. Final Exam

Total:

2 credit

hours 15.

34 | P a g e


5.1. Lectures

5.2. Assignments, Self-learning

5.3. PBL

5.4. L.M.S (Moodle)



1. Written exam To assess knowledge, understanding, intellectual and professional skills.

2. Course work To assess knowledge, understanding, intellectual, professional and

general& transferable skills.


and confidence.





Assessment 3 Assignments (presentation) all over the term




1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment (presentation) 5


3. Oral Exam 10

Total 100%


No. Reference Type

1.

A- Biostatistics, Basic concepts and methodology for the health

sciences, 10th Edition, Wiley (2014)

B- Drug discovery and evaluation: Pharmacologic assays, Vogel

and Vogel (2013), Springer.

C- Basic and Clinical Biostatistics, Beth D. Saunders, Robert G.

Trapp; (2012), McGraw-Hill publishing Company.

Textbook

2 Statistical Methods in Medical Research

(https://journals.sagepub.com/home/smm) Periodical

https://journals.sagepub.com/home/smm

35 | P a g e


7.1.Lectures:

Study


ILOs

K&U IS P&PS G&TS

1.

Introduction of statistics + strategies to

understand the meaning of data

(descriptive statistics)

a1 b1 c2 --

2.

Measures of central tendency (mean,

median, mode) + measures of

dispersion (range, variance and

standard deviation)

a1 b1,b2 -- --

3. Hypothesis testing (one sample t-test) a3 b3 c1 --

4. Hypothesis testing (Unpaired and

paired student t-test) a3 b3 c1 d2

5. Hypothesis testing (ANOVA test) and

Chi-X2 test a3 b3 c1 d2

6.

Correlation, regression, measures of

mortality and morbidity and non-

parametric tests.

a3 b3 c1 d1,d2

7. Applications (Exercise + PBL) a1,a3 b3 c1,c2 d1,d2

9. Screening and bioassay of autonomic

drugs a2,a4,a5 b4,b5 c3,c4 d3

10. Screening and bioassay of skeletal

muscle relaxants a4,a5 b4 c3,c4 d3

11.

Screening and bioassay of analgesics,

anti-inflammatory drugs and local

anesthetics

a2,a5 b4 c3,c4 d3

12. Screening and bioassay of insulin and

cardiac glycosides a4,a5 b4,b5 c4 d3

13. Screening and bioassay of

antihypertensive drugs a4,a5 b4,b5 c4 d3

Name Signature

Course Coordinator: Dr. Ahmed Esam Khodir



36 | P a g e





Course Title: OTC abuse

Course Code: PB 435


Department offering the course: Pharmacology and biochemistry

Academic year/ level: Fall Semester 2017/2018 Level 4.

Prerequisite: None

Credit hours: Lecture: 2 Practical: 0 Total:2

2. Course Aims:

To provide an overview of the basic concepts of drug abuse and the necessary knowledge

about different classes of over the counter (OTC) drugs of great abuse susceptibility. The

course provides further information about the driving forces and the different reasons of abuse

in addition to the major signs and symptoms of drug toxicity and abuse. Furthermore, the

course outlines the methods of prevention of drug misuse.




A1 a1. Identify the basic pharmaceutical drugs abused and their impact on health

A16

a2. Recognize the toxic profile of cough suppressant and decongestant drugs.

a3. Define the symptoms and measures of prevention of drug misuse.

a4. Differentiate between symptoms of abuse of caffeine, hypnotics and opiate

drugs

a5. List main classes of abused drugs.



B15

b1. Estimate health hazards concerning drug abuse.

b2. Predict vulnerabilities concerning drug misuse and exposure to toxic agents.

b3. Analyze the symptoms of drug abuse.

b4. Assess the legal regulations concerning abuse of drugs

37 | P a g e



C9

c1. Raise public awareness on rational use of drugs.

c2. Monitor social health hazards of drug abuse and misuse.

c3. Manipulate different risks concerning drug misuse.

C10 c4. Counsel patients about safe use of OTC medications



D3 d1 Work effectively within a team frame.

D6 d2 Develop the skills required for self-learning

4. Contents:

4.1.Lectures:

4.2.Practical: Not Applicable


5.1. Lectures.

5.2. Self-learning.

5.3. Activity/assignments ( homework)

5.4. L.M.S.

Study

week Topics

No. of

Credit Hours

1. Introduction to drug abuse 2

2. Cough suppressant (dextromethorphan) abuse 2

3. Decongestant (pseudoephedrine) abuse 2

4. Laxative abuse + Quiz 1 2

5. Antihistamine abuse 2

6. Diet pills abuse 2

7. Caffeine abuse 2

8. Quiz 2

9. Abuse of sedatives and hypnotics 2

10. Abuse of opioids 2

11. Abuse of acetaminophen 2

12. Abuse of NSAIDs 2

13. Abuse of amphetamine 2

14. Final Exam

Total:

2 credit hours 15.

38 | P a g e




skills.




and confidence.





Assessment 3 Assignment (homework) all over the term

Assessment 4 Written exam 14th&15thweeks

Assessment 5 Oral exam weeksth& 15th 14


1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment 5


3. Oral Exam 10

Total 100%


No. Reference Type

1. Abusing Over-the-Counter Drugs: Illicit Uses for Everyday Drugs

(Illicit and Misused Drugs) by Kim Etingoff 2012 Textbook

2 https://drugabuse.com/library/otc-drug-abuse/ Website


8.1.Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Introduction to drug abuse a1, a5 b1, b4 c1 --

2. Cough suppressant (dextromethorphan)

abuse a2, a3 b2, b3 c2, c4

--

3. Decongestant (pseudoephedrine) abuse a2, a3 b2, b3 c3, c4 d1,d2

http://www.amazon.com/Kim-Etingoff/e/B001JS33EC/ref=sr_ntt_srch_lnk_1?_encoding=UTF8&qid=1264605410&sr=8-1

https://drugabuse.com/library/otc-drug-abuse/

39 | P a g e

4. Laxative abuse a3 b2, b3 c3, c4 d1,d2

5. Antihistamine abuse a3, a5 b2, b3 c3, c4 d1,d2

6. Diet pills abuse a3 b2, b3 c2, c4 d1,d2

7. Caffeine abuse a3, a4 b2, b3 c3, c4 d1,d2

9. Abuse of sedatives and hypnotics a3, a4

b2, b3 c2,c3, c4 d1,d2

10. Abuse of opioids a3, a4

b3, b4 c2, c3 d1,d2

11. Abuse of acetaminophen a3 b2, b3 c3, c4 d1,d2

12. Abuse of NSAIDs a3, a5 b2, b3 c3, c4 d1,d2

13. Abuse of amphetamine a3 b2, b3 c2,c4 d1,d2

Name Signature

Course Coordinator: Dr. Eman Mahmoud

Head of Department: Prof. Dr. Hassan El Kashef


40 | P a g e





Course Title: General Biology

Course Code: PB 101




Prerequisite: None


2. Course Aims:

The course provides the basic principles of biology and taxonomy, classification of

prokaryotes and eukaryotes with an emphasis on cellular structure. It describes the functions

of organelles and regulatory mechanisms in animal cells.




A1

a1. Identify the fundamental concepts of biology, taxonomy with an emphasis on

animal cell structure and function.

a2. Describe the basic characteristics of prokaryotic and eukaryotic cells and

extracellular matrix.

A4 a3. Enumerate the theories of transport across the biological membranes.

A11 a4.

Recall the basic principles of cellular function, including cell communication,

ligands and receptors.

a5 Describe cell death mechanisms in normal and cancer cells.



B18

b1. Correlate cell structure with its function, including active and passive

transport across membrane.

b2. Integrate basic biochemical facts with mechanisms of apoptosis of normal

cells and tumor formation.

b3. Investigate the characteristics of living things to classify organisms into

eukaryotes and prokaryotes.

41 | P a g e



C1 c1. Utilize gained information to communicate with other health care professionals

C11 c2.

Apply biology knowledge to practical scientific activities and relevant

applications of biology in society and the environment.

c3. Conduct research studies including presentation skills and discussion

C13 c4. Monitor risks concerning incompatibilities in drug substances with

regulatory signals of cell cycle leading to necrosis or apoptosis



D3 d1. Work effectively as a part of a team to perform the required tasks.

D4 d2. Collect, evaluate and present data.

D6 d3. Develop the skills required for continued self-professional development and

self-learning.

4. Contents:

4.1.Lectures:

Study

week Topics

No. of

Credit Hours

1. Introduction to biology; characteristics of living things 2

2. Classification of organisms; principles of taxonomy 2

3. Prokaryotes versus eukaryotes ; animal cell structure 2

4. Organelles functions + quiz 1 2

5. Biological membranes structure and function 2

6. Membrane passive transport and osmosis 2

7. Membrane active transport 2

8. Quiz 2

9. Cytoskeleton and extracellular matrix 2

10. Communication between cells 2

11. Ligands and receptors 2

12. Apoptosis and tumors 2

13. Revision

14. Final Exam

Total:

2 credit hours 15.

42 | P a g e


5.1. Lectures

5.2. Research in library and web (homework and assignments)

5.3. Presentation of research topics

5.4 Discussion

5.5 E-learning using MOODLE system



1. Written exam to assess knowledge, understanding, intellectual and professional

skills.

2. Course work to assess knowledge, understanding, intellectual skills, general &


3. Quizzes to assess knowledge, understanding and intellectual skills.




Assessment 3 Assignment/activity (Research) all over the term



1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (Research.) 5


Total 100%


No. Reference Type

1. Lippincott Illustrated Reviews: Cell and Molecular Biology by Nalini

Chandar and Susan Viselli 1st Edition (Lippincott Illustrated Reviews

Series, 2010)

textbook

2. Cell Biology and Histology by Gartner, Leslie P., Hiatt, James L.,

Strum, Judy, 5th Edition [Lippincott Williams & Wilkins, 2006] textbook

3. Biology, Peter H. Raven. [McGraw-Hill Education; 11th edition

(2016)] Online Book

https://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&text=Nalini+Chandar+PhD&search-alias=books&field-author=Nalini+Chandar+PhD&sort=relevancerank

https://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&text=Nalini+Chandar+PhD&search-alias=books&field-author=Nalini+Chandar+PhD&sort=relevancerank

https://www.amazon.com/s/ref=dp_byline_sr_book_2?ie=UTF8&text=Susan+Viselli+PhD&search-alias=books&field-author=Susan+Viselli+PhD&sort=relevancerank

43 | P a g e


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1.

Introduction to biology; Characteristics

of living things a1

b1

b3

c1

c2 --

2. Classification of organisms; Principles

of taxonomy a1 b3 c1 --

3. Prokaryotes versus and Eukaryotes;

Animal cell structure a2

b1

b3 c2 d3

4. Organelles functions a1

a4

b1

b3

c2

c3

d1

d2

5. Biological membranes structure and

function

a3

a4 b1

c1

c2 d3

6. Membrane passive transport and

osmosis

a3

a4 b1 c2 d3

7. Membrane active transport a3

a4 b1

c2

c3

d1

d2

8. Quiz 2

9. Cytoskeleton and extracellular matrix a2

a4 b1

c2

c3

d1

d2

10. Communication between cells a4 b1

b2

c2

c4 d3

11. Ligands and receptors a4 b1

b2 c4 d3

12 Apoptosis and Tumors a5

b2

c4 d3

Name Signature

Course Coordinator: Dr. Rania Khalil

Head of Department: Prof. Dr. Hassan El Kashif


44 | P a g e





Course Title: Biochemistry-1

Course Code: PB 221




Prerequisite: Physical Chemistry (PC 102)


2. Course Aims:

The course aims to understand the basic principles of biochemistry and its importance for

living organisms and integrates chemical structure of macromolecules (carbohydrates,

proteins, lipids) with its functions. It describes the general characters of enzymes, functions,

mechanisms of action, kinetics, and regulation. It explains concepts as vitamins, porphyrins

and biological oxidation.




A1 a1. Identify the basic principles of biochemistry, including chemistry of

carbohydrates and their classification, structure and function.

A4

a2. List the chemical structures of proteins and lipids macronutrients and

illustrate their functions.

a3. Enumerate the theories of enzyme action, enzymes inhibition and the role of

enzymes in disease diagnosis.

a4.

Describe vitamins; chemical structure, function, properties and deficiency

problems, and recognize porphyrins, biological oxidation and electron

transport chain.



B18

b1 Correlate basic biochemical facts of carbohydrates with its importance in the

formation of nucleic acid and immune response in the body.

b2. Evaluate the importance of lipids as precursor of prostaglandins, leukotrienes

and thromboxane

b3. Integrate basic biochemical facts concerning body peptides, proteins and

enzymes with its role in human body functions.

45 | P a g e

B21 b4. Predict symptoms end effects of vitamins deficiencies in a given case study

report.



C2 c1. Handle and dispose laboratory reagents safely using instruments in biochemistry

laboratory

C11 c2.

Conduct research studies concerning important molecules (lipoproteins,

porphyrins, mucopolysaccharides) in the body including presentation, and

interpretation of biochemical data.

C14 c3. Employ different qualitative diagnostic tests for different types of carbohydrates

and proteins






self-learning.

4. Contents:

4.1. Lectures:

Study

week Topics

No. of

Credit Hours

1. Basic principles of carbohydrates chemistry;

monosaccharaides structure and function 2

2. Disaccharides chemistry 2

3. Polysaccharides chemistry 2

4. Simple lipids chemistry + Quiz 1 2

5. Complex lipids chemistry ; function in biological membrane 2

6. Lipoproteins 2

7. Amino acids and protein chemistry 2

8. Quiz 2

9. Porphyrins 2

10. Enzymes 2

11. Vitamins 2

12. Biological oxidation and electron transport chain 2

13. Revision 2

14. Final Exam

Total:

2 credit hours 15.

46 | P a g e

4.2. Practical:

Study

week Topics

No. of

Credit Hours

1. Introduction, handling processes & safety

Qualitative determination of monosaccarides; glucose 1

2. Qualitative determination of monosaccarides; fructose 1

3. Qualitative determination of disaccharides; sucrose 1

4. Qualitative determination of disaccharides; lactose and maltose

+ Quiz 1 1

5. Qualitative determination of polysaccharides; starch 1

6. Qualitative determination of polysaccharides; dextrin 1

7. Qualitative determination of albumin 1

8. Quiz 2

9. Qualitative determination of neutral proteins; peptone 1

10. Qualitative determination of neutral proteins; gelatin 1

11. Qualitative determination of alkaline proteins; metaprotein 1

12. Qualitative determination of alkaline proteins; Caseinogen 1


14. Final Exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Practical lab

5.3 Research in library and web (homework & assignments)

5.4 E-learning (Moodle system)




skills.

2. Practical exam to assess professional and practical skills.



4. Oral exam to assess knowledge, understanding, intellectual skills, general skills

and confidence.


47 | P a g e

6.2. Assessment schedule:



Assessment 3 Assignment/activity (Research, assignment

using electronic system (Moodle)) all over the term





1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (Research, assignment using electronic

system (Moodle)) 5


3. Oral Exam 10


Total 100%


No. Reference Type

1. Biochemistry (Lippincott Illustrated Reviews Series) by Denise R.

Ferrier (Lippincott Williams & Wilkins; 6th Edition, 2013) Textbook

2. Biochemistry, Mary K. Campbell, Shawn O. Farrell. Thomson

Brooks/Cole 2014, 8th Edition

Textbook

3. Medical biochemistry by M.D. Chatterjea and Shinde Rana (Jaypee

Brothers Medical Pub; 8th edition, 2011)

Textbook

4. Clinical Chemistry by W. J. Marshall, Márta Lapsley (8th Edition,

2016).

Textbook


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1.

Basic principles of carbohydrates

chemistry; monosaccharaides structure

and function

a1 b1 c3 --

2. Disaccharides chemistry a1 b1 c3 --

3. Polysaccharides chemistry a1 b1 c2 d1,d2

https://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&field-author=Denise+R.+Ferrier+PhD&search-alias=books&text=Denise+R.+Ferrier+PhD&sort=relevancerank


48 | P a g e

4. Simple lipids chemistry a2 b2 -- d1,d2

5. Complex lipids chemistry ; function in

biological membrane a2 b2 c2 d2

6. Lipoproteins a2 b2 c2 d2

7. Amino acids and protein chemistry a2 b3 c3 d2

d3

9. Porphyrins a4 b3 c2 d1

d2

10. Enzymes a3 b3 -- d3

11. Vitamins a4 b4 -- d1

d2

12. Biological oxidation and electron

transport chain a4 -- -- d3

8.2.Practical:

Study


ILOs

K&U IS P&PS G&TS

1.

Introduction, handling processes &

safety

Qualitative determination of

monosaccarides; glucose

a1 b1 c1 --

2. Qualitative determination of

monosaccarides; fructose a1 b1 c1,c3 --


disaccharides; sucrose a1 b1 c3 d1


disaccharides; lactose and maltose a1 b1 c3 d1,d2


polysaccharides; starch a1

b1

c2,c3 d1-d3


polysaccharides; dextrin a1

b1

c2,c3 d1-d3

7. Qualitative determination of albumin a2

b3 c1,c3 d1,d3

9. Qualitative determination of neutral

proteins; peptone a2 b3 c3 d1,d3

49 | P a g e

10. Qualitative determination of neutral

proteins; gelatin a2 b3 c3 d1,d3

11. Qualitative determination of alkaline

proteins; metaprotein a2 b3 c3 d1,d3

12. Qualitative determination of alkaline

proteins; Caseinogen a2 b3 c3 d1,d3

Name Signature

Course Coordinator: Dr. Samuel Tanas



50 | P a g e





Course Title: Biochemistry-2

Course Code: PB 222




Prerequisite: Biochemistry-1 (PB 221)

Credit hours: Lecture:2 Practical:1 Total: 3

2. Course Aims:

This course explains how biochemistry relates to wellness and disease processes and its direct

relationship to understanding pharmaceutical principles. The course describes the biosynthetic

processes leading to the generation of macromolecules and the regulatory processes

underlying its biosynthesis and their function in cellular systems. It identifies intermediary

metabolism in terms of energy production and maintaining cellular homeostasis. Integration

between metabolic control and biochemical disorders is also considered.




A1

a1. Identify the principles of metabolism and recall the essential facts and

advanced concepts of digestion and absorption.

a2.

Describe the functions and metabolic pathways of macromolecules

(carbohydrates , lipids, proteins) and their hormonal and non-hormonal

regulatory mechanisms

A4 a3.

Enumerate metabolic disorders that have biochemical and clinical

implications, and describe biologically active compounds synthetized from

amino acids

A11 a4.

Describe the biochemical basis of some diseases, including diabetes

mellitus, glycogen storage diseases and outlines the fate of biological

compounds.

51 | P a g e



B14 b1. Evaluate evidence-based biomedical information and investigate the

metabolic disturbance in a given case study report.

B17

b2.

Determine suitable methods of analysis of different levels of glucose, total

proteins, ALT, AST, bilirubin, albumin, cholesterol, TG, creatinine and uric

acid in biological fluids

b3. Formulate a systemic approach for the laboratory experimental diagnosis

B18 b4. Correlate basic biochemical facts in cases of liver and kidney diseases with

laboratory data.

B21 b5. Interpret laboratory tests with the impact of signs and symptoms in case of

metabolic disorders.



C2 c1. Handle and dispose laboratory reagents and biological specimen safely

utilizing instruments used in biochemistry laboratory

C4 c2.

Select appropriate methods for identification and analysis of active

substances in biological fluids (colorimetric estimation using

spectrophotometer)

C14 c3.

Employ different quantitative diagnostic tests of some blood parameters

(serum levels of glucose, total proteins, albumin, bilirubin, ALT, AST,

cholesterol, TG, creatinine and uric acid).






self-learning.

4. Contents:

4.1.Lectures:

Study

week Topics

No. of

Credit Hours

1. Introduction to metabolism; Carbohydrate digestion and

absorption 2

2. Oxidation of glucose; Glycolysis 2

3. Gluconeogenesis 2

4. Krebs cycle + Quiz 1 2

5. Pentose phosphate pathway 2

52 | P a g e

4.2.Practical:

Study

week Topics

No. of

Credit Hours

1. Introduction, handling processes and safety 1

2. Determination of blood glucose level 1

3. Liver function, albumin and total protein determination 1

4. Bilirubin determination 1

5. Urea and uric acid determination 1

6. Kidney function; creatinine determination 1

7. Lipid profile; Cholesterol determination 1

8. Quiz 2

9. Lipid profile; Triglyceride determination 1

10. Urine analysis 1

11. Calcium determination 1

12. Revision 1


14. Final Exam

Total:

1 credit hour 15.

6. Glycogenesis and Glycogenolysis 2

7. Fatty acids synthesis 2

8. Quiz 2

9. Beta oxidation of fatty acids 2

10. Ketogenesis and ketolysis 2

11. Amino acids synthesis and degredation 2

12. Nitrogenous compounds metabolism and urea cycle 2

13. Biologically active compounds synthesized from amino acids 2

14. Final Exam

Total:

2 credit hours 15.

53 | P a g e


5.1. Lectures

5.2. Practical lab


5.4. Cases study

5.5 E-learning using Moodle system




skills.

2. Practical exam to assess professional and practical skills.

3. Course work to assess knowledge, understanding, intellectual skills, general and



and confidence.





Assessment 3

Assignment/activity (Assignments on the

electronic system (Moodle), schematic diagram

poster and case study)

all over the term





1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (Assignments on the electronic system

(Moodle), schematic diagram poster and case study) 5


3. Oral Exam 10


Total 100%

54 | P a g e


No. Reference Type

1. Biochemistry (Lippincott Illustrated Reviews Series) by Denise R.

Ferrier (Lippincott Williams & Wilkins; 6th Edition, 2013) Textbook

2. Biochemistry, Mary K. Campbell, Shawn O. Farrell. Thomson

Brooks/Cole 2014, 8th Edition Textbook

3. Medical biochemistry by M.D. Chatterjea and Shinde Rana (Jaypee

Brothers Medical Pub; 8th edition, 2011) Textbook

4. Clinical Chemistry, by W.J. Marshall, Márta Lapsley (8th Edition,

2016). Textbook


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1.

Introduction to metabolism;

Carbohydrate digestion and

absorption

a1 b1 -- --

2. Oxidation of glucose; Glycolysis a2,a3 b2,b3 c2 d3

3. Gluconeogenesis a2,a3 b2,b3 c2 d3

4. Krebs cycle a2,a3 b1,b2 c3 d2

5. Pentose phosphate pathway a3,a4 b1 c3 d2

6. Glycogenesis and Glycogenolysis a3,a4 b3,b4,b5 c2 d3

7. Fatty acids synthesis a2 b2,b3,b4 c2 d1

d2

9. Beta oxidation of fatty acids a2,a3 b2,b3,b5 c3 d1

d2

10. Ketogenesis and ketolysis a2,a3 b2,b3, b5 c3 d1,d3

11. Amino acids synthesis and

degredation a2,a3 b1 c2 d1

12. Nitrogenous compounds catabolism

and urea cycle a3,a4 b3, b5 c3 d1

13. Biologically active compounds

synthesized from amino acids a3 b2,b4 c3

d1



55 | P a g e

8.2. Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Introduction, handling processes and

safety

a1

--

c1

c2 --

2. Determination of blood glucose level a4

b2

c2

c3 d1

3. Liver function, albumin and total

protein determination

a3

a4

b2

b4

c2

c3 d1

4. Bilirubin determination a3

a4

b2

b4 c3 d1,d2

5. Urea and uric acid determination a3

a4

b2

b4 c3 d1,d2

6. Kidney function; creatinine

determination

a3

a4

b2

b4

c2

c3 d1,d3

7. Lipid profile; Cholesterol

determination

a2

a3

b1

b2

b3

c3 d2,d3

9. Lipid profile; Triglyceride

determination

a2

a3

b1

b2

b3

c3 d2,d3

10. Urine analysis -- b2

b4

c2

c3 d2,d3

11. Calcium determination a3

a4 b5 c3 d2,d3

Name Signature

Course Coordinator: Dr. Hanan Hafila



56 | P a g e





Course Title: Clinical Biochemistry

Course Code: PB 422




Prerequisite: Biochemistry-2 (PB 222)

Credit hours: Lecture:2 Practical: 0 Total:2

2. Course Aims:

This course provides an overview of how biochemical investigations are employed to develop a

clinical diagnosis. To understand the biochemical changes accompanied to metabolic disorders

and the role of endocrine system in its regulation. It describes disorders of liver and kidney

functions with its various diagnostic tests. It illustrates clinical enzymology, tumor markers and

different techniques and devices used in in clinical biochemistry laboratory.




A1

a1. Describe major concepts and applications of clinical biochemistry.

a2.

Recognize the functions and blood levels of hormones, including adrenal

gland, thyroid gland, pituitary gland, gonads and insulin hormone, in health

and disease state.

A11

a3.

Define the principles of laboratory diagnosis (the reference range) and

clinical aspects of different disorders in cases of liver, kidney and blood

diseases.

a4. Recall main enzymes used as diagnostic markers in different diseases

a5 Define tumor markers and outline the most common tumor markers used for

laboratory diagnosis of different malignancies.



B13 b1. Interpret laboratory results based on relevant biochemical principles.

B14 b2. Evaluate evidence-based information (complete blood counts and blood

indices) needed in clinical decisions.

57 | P a g e

B17 b3.

Formulate a systemic approach for the laboratory clinical diagnosis using

clinical enzymology and tumor markers in liver, kidney and endocrine

disorders

B18 b4. Integrate basic biochemical and physiological facts in cancer with clinical

data

B21 b5. Interpret clinical laboratory tests in liver, kidney and endocrine disorders

with the impact of clinical symptoms.



C1 c1.

Utilize the proper information about endocrine system, clinical enzymology

and complete blood counts to communicate with other health care

professionals

C5 c2.

Apply good pharmacy practice by proper understanding of human

physiology and pathophysiology of endocrine system disorders, cancer, liver

and kidney disease.

C11 c3. Conduct scientific research using internet materials followed by presentation,

analysis and interpretation of the results.



D3 d1. Work effectively as a part of a team to perform the required tasks

D6 d2. Develop skills required for self-learning

D11 d3. Generate effective and reasonable solutions for rising problems based on the

available information.

4. Contents:

4.1.Lectures:

Study

week Topics

No. of

Credit Hours

1. Endocrine system: overview 2

2. Thyroid gland and its disorders 2

3. Male and female Reproductive system and their disorders 2

4. Male and Female infertility; hormonal profile and semen

analysis + Quiz 1 2

5. Kidney diseases and Kidney function tests 2

6. Liver biochemical role; its disorders and liver function tests 2

7. Anterior Pituitary gland and its disorders 2

8. Quiz 2

9. Posterior Pituitary gland and its disorders 2

10. Clinical Enzymology 2

58 | P a g e


5.1. Lectures


5.3. Discussion

5.4. Case study (tutorial classes)

5.5. E- learning using Moodle system




skills.




and confidence.





Assessment 3 Assignment/activity (case study) all over the term




1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (case study) 5


3. Oral Exam 10

Total 100%

11. Tumor markers 2

12. Adrenal glands and its disorders 2

13. Complete blood counts and blood indices 2

14. Final Exam

Total:

2 credit hours 15.

59 | P a g e


No. Reference Type

1.

Tietz Fundamentals of Clinical Chemistry and Molecular

Diagnostics by Carl A. Burtis, and David E. Bruns, editors.

(St. Louis, MO: Elsevier Saunders; 7th edition, 2014).

Bishop Textbook for Clinical Chemistry principles,

techniques and correlations by Michael L. Bishop , Edward P.

Fody and Larry E. Schoeff (Lippincott Williams & Wilkins;

7th edition, 2013).

Clinical biochemistry: An Illustrated Color Text, By Allan

Gaw Michael Murphy Rajeev Srivastava Robert Cowan

Denis O'Reilly. (Churchill Livingstone; 5th edition, 2011).

Textbook

2.

Clinical Chemistry. http://clinchem.aaccjnls.org/

Periodicals.

Web site

Clinical Chemistry and Laboratory Medicine.

https://www.degruyter.com/view/j/cclm

Annals of Clinical Biochemistry.

https://journals.sagepub.com/toc/acb/current


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Endocrine system: overview a1 b1 c1

c2 ---

2. Thyroid gland and its disorders a2 b3

b5

c2

c3 ---

3. Male and female Reproductive system

and their disorders

a2

b3

b5

c2

c3 d3

4. Male and Female infertility; hormonal

profile and semen analysis + Quiz 1 a2

b3

b5

c2

c3 d3

5. Kidney diseases and Kidney function

tests a1, a3 b3

c2

c3 d2

6. Liver biochemical role; its disorders

and liver function tests a1, a3 b3 c3 d2

7. Anterior Pituitary gland and its

disorders a2 b5

c2

c3

d1

d3

9. Posterior Pituitary gland and its

disorders a2 b5

c2

c3

d1

d3

10. Clinical Enzymology a1, a4

b3 c1 d3

60 | P a g e

11. Tumor markers a1, a5

b4 c2 d1

12. Adrenal glands and its disorders a2

b1

b3

b5

c1

c2

c3

d1

d3

13. Complete blood counts and blood

indices

a1, a3

b1

b2 c1 d2

Name Signature

Course Coordinator: Dr. Samuel Tanas



61 | P a g e

Other Courses Not Opened for Registration

at Academic Year (2017-2018)

Final Approval 2016-2017

62 | P a g e


Course title: Pharmacogenomics Course code: PB 523


Department: Pharmacology & Biochemistry

Academic level: Faculty Elective course

Prerequisite: None


2. Course Aims:

2.1. Understanding the drug efficacy and safety and the need to optimize these factors in

pharmacotherapy.

2.2. Identify how genetic variability influence the overall drug response.

2.3. Provide a detailed overview of the burgeoning field of genomic medicine and

pharmacogenomics.




A1 a1 Describe and define basic pharmacogenomics, concepts and taxonomy

A12

a2 Identify the basic principles and methods of diagnosis of pharmacogenomics and

pharmacogenetics.

a3 Evaluate polymorphism types and their impact on pharmacokinetics and

pharmacodynamics.



B7

b1 Determine the theories, application of DNA mutations and repair systems.

b2 Verify the role and implications of pharmacogenomics in discovery of new drugs

and treatment strategies.

b3 Explore the implications of the ethical, legal, social and economic issues related to

pharmacogenomic testing.



C5

c1 Employ the safe and effective use of drugs on patients

c2 Decide the roles of pharmacogenomics and pharmacogenetics in health and

disease



D2 d1. Obtain up-to-date resources for pharmacogenomic information.

D3 d2. Identify the problem affecting community with trial of solving by teamwork.

63 | P a g e

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

credit

hours

1. Introduction 2

2. History of pharmacogenomics 2

3. Genomics in human health & bioethics 2

4. Genetic basis of pharmacogenomics and pharmacogenetics 2

5. Genetic basis of pharmacogenomics and pharmacogenetics 2

6. Molecular techniques and diagnostics 2

7. Mid-Term exam ---

8. Pharmacogenetics of drug metabolism 2

9. Pharmacogenetics of drug metabolism 2

10. Pharmacogenomics and drug transport 2

11. Pharmacogenomics and drug transport 2

12. Pharmacodynamics and pharmacogenomics 2

13. Pharmacodynamics and pharmacogenomics 2

14. Final Exam

2 credit

hours 15.


5.1. Lectures

5.2. Seminars



1. Written exam to assess knowledge, understanding, intellectual and professional skills

2. Class work to assess knowledge, understanding, intellectual skills, general skills and

confidence


Assessment 1 Mid-term 7th week

Assessment 2 Quiz 10th week

Assessment 3 Written 14th &15th weeks


Mid-Term Exam & course work 25 %

Final-Term Exam 75 %

Total 100%

64 | P a g e


No. Reference type

1.

1.1. Pharmacogenomics and Personalized Medicine

(Methods in Pharmacology and Toxicology) by Nadine

Cohen 2008 edition

1.2. Pharmacogenomics: Applications to Patient Care,

ACCP

textbook


Study

week Course contents

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1 Introduction a1 b1,b3 c2 d1

2 History of pharmacogenomics a1 b1 -- --

3 Genomics in human health &

bioethics a1 b1,b3 c2 d1

4-5

Genetic Basis of

Pharmacogenomics and

pharmacogenetics

a1,a2 b1 c2 d1

6 Molecular Techniques and

Diagnostics a2, b2,b3 c1 d1

8-9 Pharmacogenetics of Drug

Metabolism a3 b2 c1 d2

10-11 Pharmacogenomics and Drug

Transport a3 b2 c1 d2

12-13 Pharmacodynamics and

Pharmacogenomics a3 b2,b3 c1 d2

Name Signature

Course Coordinator: Prof. Dr. Hassan A. Elkashef



65 | P a g e


Course title: Clinical toxicology Course code: PB 522


Department: Pharmacology and Biochemistry

Academic level: Elective course

Prerequisite: None

Credit hours: Lecture: 2 Practical: Total: 2

2. Course Aims:

2.1 Learn the basics of forensic medicine that will enable the student to make medico-legal

judgment on simple cases of injuries.

2.2 Learn the basics of clinical toxicology that will enable the student to diagnose and manage

intoxicated patients.




A16

a1 Understand the general principles of poisoning management; explain actions,

interactions, uses and toxicity of certain medications.

a2 Understand toxic profile of various drugs and other xenobiotics including

sources, identification, symptoms, management, control and first aid measures.

A25 a3

Illustrate clinical features of diseases and appropriate medical intervention in

emergency situations, with stress on some genetic abnormalities and toxicology

of addiction and to define the principles of body function in health and disease

states; as well as the etiology, epidemiology, laboratory diagnosis, clinical aspects

of different diseases; and their pharmacotherapy



B11 b1

Assess drug-drug interactions, food drug interactions, adverse drug reactions and

predict possible incompatibilities and other prescription-related problems that

may occur during drug dispensing

B21

b2 Analyze, evaluate and interpret clinical cases of toxicity and estimate health

hazards concerning drug abuse, misuse and exposure to toxic agents.

b3

Differentiate between different toxic agents regarding their symptoms, as well as

their main lines of toxicity treatment and interpret clinical laboratory tests with

the impact of clinical symptoms.



C7 c1 Undertake risk assessments concerning drug-drug interactions, adverse reactions,

toxicity profile and incompatibilities

C9 c2 Counsel patients when dispensing OTC and prescription drugs to ensure safe and

proper use of medicines.

C21 c3 Determine the toxicity profiles of different xenobiotics and chemotherapeutic

agents, detect poisons in biological specimens

66 | P a g e



D1 d1 Communicate effectively with patients and health care professionals

D2 d2 Retrieve pharmaceutical, clinical and other drug information resources.

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

credit

hours

1. Basic principles of clinical toxicology 2

2. Management of an intoxicated patient 2

3. Household intoxication 2

4. Medical toxicology 2

5. Medical toxicology 2

6. Environmental Pollutants 2

7. Mid-term exam --

8. Substances of abuse 2

9. Drug dependence 2

10. Plant toxicity 2

11. Animal envenomation 2

12. Food-born intoxication 2

13. Revision 2

14. Final Exam

2 credit

hours 15.


5.1. Lectures

5.2. Small group discussions (problem based learning)

5.3. Case study



1. Mid-term to assess knowledge, understanding, intellectual skills, general skills

2. Quiz to assess knowledge, understanding, intellectual skills, general skills






67 | P a g e


Mid-Term Exam 15%

Quiz 10%

Final-Term Exam 75%

Total 100%


No. Reference Type

1. Molecular, Clinical and Environmental Toxicology, 2009 Textbook

2.

Clinical Toxicology

http://toxnet.nlm.nih.gov

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi

Website


Study


ILOs

knowledge

and

understanding

intellectual

skills

professional

and practical

skills

general and

transferable

skills

1 Basic principles of clinical

toxicology a1 -- c1, c2, c3 --

2 Management of an

intoxicated patient a1, a2, a3 b1, b3 c1, c2, c3 d1, d2

3 Household intoxication a1, a2, a3 b2, b3 c1 d1, d2

4-5 Medical toxicology a1, a2, a3 b1, b2, b3 c1, c2, c3 d1, d2

6 Environmental Pollutants a1, a2, a3 b1, b2, b3 c1, c2, c3 d2

8 Substances of abuse a1, a2, a3 b1, b2, b3 c1, c2, c3 d1, d2

9 Drug dependence a1, a2, a3 b1, b2, b3 c1, c2, c3 d1, d2

10 Plant toxicity a1, a2 b2 c1 d1, d2

11 Animal envenomation a1, a2 b2 c1 d1, d2

12 Food –born intoxication a1, a2, a3 b1, b2, b3 c1, c2, c3 d1, d2

13 Revision

Name Signature

Course Coordinator: Prof. Dr. Hassan El-Kashef

Head of Department: Prof. Dr. Hassan El-Kashef


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi

68 | P a g e


Course title: Veterinary pharmacy Course code: PB 536


Department: Pharmacology & Biochemistry

Academic level: Faculty Elective course

Prerequisite: None


2. Course Aims:

1. List common adverse drug interactions in veterinary patients

2. Explain current trends in veterinary prescribing and compounding.




A2 a1

Recognize the physico-chemical properties of drugs and various substances used

in preparation of medicines, in addition to the properties of different

pharmaceutical dosage forms.

A6 a2 Describe properties of different pharmaceutical dosage forms and drug delivery

systems.

A16 a3 Recognize the toxic profile of various drugs and other xenobiotics; including

identification, symptoms, control and first aid measures.



B1 b1 Design process of formulation of safe and effective medicines and dealing with

new drug delivery systems.

B9 b2 Select the proper drugs for various disease conditions using the

pharmacotherapeutic principles.

B15 b3 Estimate health hazards concerning exposure to toxic agents.



C13 c1 Assess risks concerning drug interactions, adverse reaction and incompatibilities

in different pharmaceutical preparations.



D11 d1 Generate effective and reasonable solutions for rising problems based on the

available information.

69 | P a g e

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

credit

hours

1. Veterinary Prescribing 2

2. Compounding Concerns 2

3. Dispensing Concerns 2

4. Important Drug Interactions: NSAIDS 2

5. Important Drug Interactions: NSAIDS 2

6. Other Veterinary curiosities (as paracetamol) 2

7. Mid-Term exam --

8. Toxicity Of Human Medication For Pets 2

9. Insulin Dosing In Veterinary Species 2

10. Treatment of common disease (infection) 2

11. Treatment of common disease (infection) 2

12. Treatment of common disease (musculoskeletal) 2

13. Treatment of common disease (neurological) 2

14. Final Exam

2 credit

hours 15.


5.1. Lectures

5.2. Case study




2. Class work to assess knowledge, understanding, intellectual skills, general skills and

confidence

3. Quizzes to assess knowledge, understanding and intellectual skills

4. Case study to assess the skills of problem-solving and data presentation






Mid-Term Exam & course work 25%

Final-Term Exam 75%

Total 100%

70 | P a g e


No. Reference type

1. Veterinary pharmacy by Steven B. Kayne and Michael H.

Jopson 2005 textbook


Study


ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1. Veterinary Prescribing a1, a2 b1, c1 --

2. Compounding Concerns a1, a2 b1, c1 --

3. Dispensing Concerns a1, a2 b1, c1 --

4. Important Drug Interactions

NSAIDs a1,a3 b3 c1 d1

5. Important Drug Interactions

NSAIDs a1,a3 b3 c1 d1

6. Other Veterinary Curiosities a1,a3 b2 c1 d1

8 Toxicity of Human

Medication For Pets a3 b3 c1 d1

9 Insulin Dosing In Veterinary

Species a1 b2 c1 d1

10-13 Treatment of common

diseases a3 b2, b3 c1 d1

Name Signature

Course Coordinator: Prof. Dr. Hassan A. Elkashef



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