DepartmentofPopulationMedicine

POPM*3240–EpidemiologyWinter2016

CourseCoordinator/Instructor

Dr.AndriaJones-BittonDepartmentofPopulationMedicineOVCStewartBuilding,Room2525

GraduateTeachingAssistants

KelseySpence(PhDStudent) LauraJaneWeber(PhDStudent)CONTACTINFORMATION:Email:teachepi@uoguelph.caTwitter:@POPM3240–ifyouuseTwitter,pleasefollowus!OfficeHours–inOVCStewartBuilding(www.uoguelph.ca/campus/map/stewart/)

Day Time Who PlaceWednesdays 3:00–4:00pm Spence/Weber Room2527Thursdays 1:00–2:00pm Jones-Bitton Room2525*AdditionalOfficeHourstobeheldaroundmidtermandfinalexaminations–dates/timeswillbeannouncedonCourselink

Classschedule:Mondays,Wednesdays,Fridays–1:30to2:20pmClasslocation:ThornbroughBuilding,Room1200(THRN1200)Calendardescription:Thiscoursepresentsthebasicconceptsofhealthanddiseaseinpopulations.Methodsusedindescriptiveandanalyticepidemiologicalstudies,includingthedesign,analysisandinterpretationofresultsforobservationalstudiesandfieldtrialsarepresented.Coursegoals:Thegoalsofthiscoursearetopresenttheepidemiologicalprinciplesandconceptsrequiredforthecollection,analysis,andinterpretationofhealthdataatthepopulationlevel.Coursecoordinator’sgoals:Tohelpfosterexcitementandinterestinepidemiology,inaclassroomenvironmentthatispositive,engagingandintellectuallychallenging.Courseobjectives:Attheendofthiscourse,thelearnershouldbeableto:

1. Describetheapplicationofepidemiologytodiseasecontrol,outbreakinvestigation,healthresearch,andcurrentpublichealth,animalhealthandOneHealthissues;

2. Identify,define,calculate,andinterpretcommonmeasuresofassociation(riskdifference,attributableriskexposed,populationattributablerisk,relativerisk,oddsratios)andmeasuresofdiseasefrequency(prevalence,risks,rates)usedinepidemiologicalresearch,andcitetheirstrengthsandlimitations;

3. Describehowtoselectappropriately-sizedsamplesfrompopulationsforsurveysandobservationalstudies;

4. Discussdiseasecausation,statisticalassociationsandcausalinference,andrankcommonstudydesignsbytheirabilitytoestablishcausality;

5. Discusstheuseofscreeningtests,identifythecriteriausedtoevaluatetests,andexplainepidemiologicalsensitivity,specificity,predictivevaluesandagreement,includinghowtocalculatethesemeasures;

6. Discussthedesign,methodologyandstrengths/limitationsofeachofthecommonobservationalandexperimentalstudytypesinepidemiology;

7. Identifyanddiscussthepotentialeffectsofcommonbiasesobservedinepidemiologicalresearch,includingvariousselectionbiases,misclassificationandconfounding;

8. Explaintheconceptsofincubationandlatentperiods,statetransitionmodels,effectiveandbasicreproductivenumbers,andgiveexamplesofstrategiestoreducethelatterfordiseasecontrol.

Evaluationmethods: PercentageofFinalGradeOnlineQuizzes 10MidtermExam1 20MidtermExam2 20GroupAssignment 15FinalExam 35§ OnlineQuizzes(5quizzes,each2%,foratotalof10%offinalgrade)

Thesequizzesareshort,multiplechoicequizzesavailableonD2Lduringthefollowingtimeperiods,andcoveringthefollowingtopics:

Quiz DateAvailable

(asof2:20pm)DateDue

(by11:59pm)SessionsCovered

1 WednesdayJan.20

TuesdayJan.26 1to5inclusive

2 FridayJan.29

ThursdayFeb.4 6to9inclusive

3 MondayFeb.8

SundayFeb.14 10to13inclusive

4 FridayMar.4

ThursdayMar.10 15to21inclusive

5 FridayMar.11

ThursdayMar.17 22to24inclusive

6 MondayMar.28

SundayApr.3 26to30inclusive

Thequizzesareopen-book(i.e.feelfreetouseyournotes/text)butareindependentassessments(i.e.theyaretobedoneonyourown).NOTE:Besuretosaveeveryanswerasyounavigatethrougheachquiz.Thatway,youranswerswillbeonrecordshouldyouhaveatechnicalproblemthatpreventsyoufromfinishingyourquiz.Ifyoudohaveatechnicalproblem,youmustemailthecourseemailaccount(teachepi@uoguelph.ca)immediatelytoinformusoftheproblem.NOTE:TherewillbeNOopportunitytowriteamissedonlinequiz.OnlyFIVEquizzeswillcounttowardsyourfinalgrade-thequizwiththelowestmark(includingnon-completedquiz)willbedroppedandnotcounttowardsyourfinalgrade.

§ MidtermExam1(20%offinalgrade)–WednesdayFebruary10ThisexaminationwillbeheldinclassandcoversmaterialfromSessions1-13inclusive.Besuretobringyourownpen,pencil,eraser,andcalculator-sharingofcalculatorswillNOTbepermittedandcalculatorswillNOTbeprovidedtoyou.Thisexamwillconsistofmultiplechoice,shortanswer,andshortcalculationquestions.§ MidtermExam2(20%offinalgrade)–MondayMarch14ThisexaminationwillbeheldinclassandcoversmaterialmainlyfromSessions15-23inclusive,butpreviousmaterialmayalsostillbetested.Besuretobringyourownpen,pencil,eraser,andcalculator-sharingofcalculatorswillNOTbepermittedandcalculatorswillNOTbeprovidedtoyou.Thisexamwillconsistofmultiplechoice,shortanswer,andshortcalculationquestions.§ GroupAssignment(15%offinalgrade)–MondayMarch28Thisgroupassignmentwillinvolvethecreativedisseminationofepidemiologicalconcept(s)coveredinclasstoatargetedaudience(s)usingmultimedia.Studentswillworkingroupsoffour.Moredetailsonthisassignmentwillbegiveninclass(especiallySession13)andpostedonCourselink.§ FinalExam(35%offinalgrade)–FridayApril15*Thisexaminationwillcovermaterialspanningallsessionsofthecourse.Besuretobringyourownpen,pencil,eraser,andcalculator-sharingofcalculatorswillNOTbepermittedandcalculatorswillNOTbeprovidedtoyou.Thisexamwillconsistofmultiplechoice,shortanswer,andshortcalculationquestions.*Ascurrentlyscheduled–alwayscheckWebAdvisor,asitisprovidesofficialUniversityexamschedulingCourse&universitypoliciesRecordingofMaterialsPresentationswhicharemadeinrelationtocoursework—includinglectures—cannotberecordedorcopiedwithoutthepermissionofthepresenter,whethertheinstructor,aclassmateorguestlecturer.Materialrecordedwithpermissionisrestrictedtouseforthatcourseunlessfurtherpermissionisgranted.E-mailcommunicationAsperuniversityregulations,allstudentsarerequiredtochecktheirUniversityofGuelph<uoguelph.ca>e-mailaccountregularly.E-mailistheofficialrouteofcommunicationbetweentheUniversityanditsstudents.

WhenyoucannotmeetacourserequirementWhenyoufindyourselfunabletomeetanin-courserequirementbecauseofillnessorcompassionatereasons,pleaseadvisethecourseinstructor(ordesignatedperson,suchasateachingassistant)inwriting,withyourname,id#,ande-mailcontact.SeetheundergraduatecalendarforinformationonregulationsandproceduresforAcademicConsideration:https://www.uoguelph.ca/registrar/calendars/undergraduate/current/c08/c08-ac.shtmlRe-gradingpolicyThefollowingpolicyisinplaceforALLrequestsforre-grading(NOexceptions):MarkingschemeswillbemadeavailableonCourselinkforallmidtermexamsandassignments.Consultthemarkingschemeandcarefully/thoughtfullyreviewyouranswersandmarksreceived.Ifyoubelieveanerrorwasmade,writeashortandspecificstatementindicatingwhyyouthinkthereisanerror(i.e.youmustclearlyjustifythere-grading).Attachthestatementtotheoriginalexam/assignment,andre-submitthistoDr.Jones-BittonbydeliveringittoherofficemailboxinthePopulationMedicinemainofficeoftheOVCStewartBuildingwithinoneweek(i.e.by4:30pmon7thcalendarday)aftertheassignments/midtermsarereturnedin-class.Note:allre-gradingwillbedonebyDr.Jones-Bitton;materialswillbere-gradedinentiretyandallappropriateadjustmentsmade.StudentswillbenotifiedthroughCourselinkonthestatusoftheirre-graderequest.DropdateThelastdatetodropone-semestercourses,withoutacademicpenalty,isthe40thclassday(forWinter2016,thisisFridayMarch11,2016).RefertotheGraduateCalendarforthecompletescheduleofdates:https://www.uoguelph.ca/registrar/calendars/undergraduate/current/c03/index.shtmlForregulationsandproceduresforDroppingCourses,seetheUndergraduateCalendar:https://www.uoguelph.ca/registrar/calendars/undergraduate/current/c08/c08-drop.shtmlAccessibilityTheUniversityofGuelphiscommittedtocreatingabarrier-freeenvironment.Providingservicesforstudentsisasharedresponsibilityamongstudents,faculty,andadministrators.Thisrelationshipisbasedonrespectofindividualrights,thedignityoftheindividualandtheUniversitycommunity’ssharedcommitmenttoanopenandsupportivelearning

environment.Studentsrequiringserviceoraccommodation,whetherduetoanidentified,on-goingdisabilityorashort-termdisabilityshouldcontactStudentAccessibilityServices(SAS),formerlytheCentreforStudentswithDisabilities,assoonaspossible.Formoreinformation,contactSASat519-824-4120ext.56208oremailcsd@uoguelph.caorseethewebsite:https://www.uoguelph.ca/csd/AcademicMisconductTheUniversityofGuelphiscommittedtoupholdingthehigheststandardsofacademicintegrityanditistheresponsibilityofallmembersoftheUniversitycommunity–faculty,staff,andstudents–tobeawareofwhatconstitutesacademicmisconductandtodoasmuchaspossibletopreventacademicoffencesfromoccurring.UniversityofGuelphstudentshavetheresponsibilityofabidingbytheUniversity'spolicyonacademicmisconductregardlessoftheirlocationofstudy;faculty,staffandstudentshavetheresponsibilityofsupportinganenvironmentthatdiscouragesmisconduct.Studentsneedtoremainawarethatinstructorshaveaccesstoandtherighttouseelectronicandothermeansofdetection.Pleasenote:Whetherornotastudentintendedtocommitacademicmisconductisnotrelevantforafindingofguilt.Hurriedorcarelesssubmissionofassignmentsdoesnotexcusestudentsfromresponsibilityforverifyingtheacademicintegrityoftheirworkbeforesubmittingit.Studentswhoareinanydoubtastowhetheranactionontheirpartcouldbeconstruedasanacademicoffenceshouldconsultwithafacultymemberorfacultyadvisor.TheAcademicMisconductPolicyisdetailedintheUndergraduateCalendar:https://www.uoguelph.ca/registrar/calendars/undergraduate/current/c08/c08-amisconduct.shtmlFormoredetails,youarestronglyencouragedtoconsulttheUniversity’sAcademicIntegritytutorial,ashortbuthighlyusefulonlinetutorialtohelpinformandclearcommonmisconceptionsregardingacademicmisconduct:http://www.academicintegrity.uoguelph.ca/ResourcesTheGraduateCalendaristhesourceofinformationabouttheUniversityofGuelph’sprocedures,policiesandregulationsthatapplytograduateprograms:http://www.uoguelph.ca/registrar/calendars/graduate/current/

Coursetextbook(stronglyrecommended):Epidemiology5thedition,byLeonGordis,ElsevierSaundersCompany,Philadelphia:2014.ISBN:978-1-4557-3733-8.- AvailableinUniversityBookstore.Note:Purchasealsoallowsonlineaccess&

interactiveextras- AlsoonReserveinUniversityofGuelphlibrary

OtherRecommendedReferences(onreserveinUniversityLibrary):

• MedicalEpidemiology,4thedition;GreenbergRS,DanielsSR,FlandersWD,EleyJW,BoringJR.LangeMedicalBooks/McGraw-Hill,NewYork,NY:2005

• VeterinaryEpidemiology:PrinciplesandMethods:MartinSW,MeekAH,WillebergP.IowaStateUniversityPress,Ames,IW:1987

• VeterinaryEpidemiologicalResearch,2ndedition:DohooIR,MartinSW,StryhnH.VERInc.,Charlottetown,PEI:2009

• PopulationHealth:ConceptsandMethods,2ndedition,byYoung,TK.(OxfordUniversityPress,NewYork,NY:2005).

• ADictionaryofEpidemiology,4thedition;LastJMeditor.(OxfordUniversityPressNewYork,NY:2001).

OtherSuggestedReferences(forthereallykeen):

• MethodsinEpidemiologicResearch:DohooI,MartinW,StryhnH.(VERInc.,Charlottetown,PEI:2012)

• CriticalAppraisalofEpidemiologicalStudiesandClinicalTrials,byElwoodM.(OxfordUniversityPress,NewYork,NY:2002)

• Epidemiology-anintroductorytext,2ndedition,byMausnerJS&KramerS.(WBSaunders:Toronto;1985).

• EpidemiologyinMedicine,byHennekensCH&BuringJE.(Little&Brown,Boston:1987)

• EpidemiologyKeptSimple:anIntroductiontoClassicandModernEpidemiology,byGerstmanBB.(Wiley,NewYork,NY:1998)

• Epidemiology:anIntroduction,byRothmanKJ.(OxfordUniversityPress,NewYork,NY:2002)

• ClinicalEpidemiology:aBasicScienceforClinicalMedicine,2ndedition,bySackettDL,HaynesRB,GuyattGH,andTugwellP.(Little&Brown,Toronto:1991)

• PDQEpidemiology,2ndedition,byStreinerDL&NormanGR.(Mosby,Toronto:1996)

POPM*3240LectureScheduleWinter2016(Maybesubjecttochange)

Session Date Topic&Notes

Lecturer

1 Jan.11 IntroductiontoCourse Dr.Jones-Bitton2 Jan.13 IntroductiontoEpi&HistoricalApproaches Dr.Jones-Bitton3 Jan.15 FoundationsinHealth&DiseaseTransmission Dr.Jones-Bitton4 Jan.18 FoundationsinHealth&DiseaseTransmission Dr.Jones-Bitton5 Jan.20 StatisticalAnalysisofEpidemiologicalData Dr.Jones-Bitton6 Jan.22 SamplingI Dr.Jones-Bitton7 Jan.25 SamplingII Dr.Jones-Bitton8 Jan.27 Screening&DiagnosticTestsI Dr.Jones-Bitton9 Jan.29 Screening&DiagnosticTestsII Dr.Jones-Bitton10 Feb.1 EpidemiologyinPublicHealth Dr.V.Edge11 Feb.3 Bias&CausationI Dr.Jones-Bitton12 Feb.5 Bias&CausationII Dr.Jones-Bitton13 Feb.8 Assignment Dr.Jones-Bitton14 Feb.10 MIDTERM1 --15 Feb.12 IntroductiontoObservationalStudies L.Weber-- Feb.15

to19WINTERBREAK–NOCLASS

--

16 Feb.22 MeasuresofAssociation Dr.Jones-Bitton17 Feb.24 Cross-SectionalStudies Dr.Jones-Bitton18 Feb.26 CohortStudiesI Dr.Jones-Bitton19 Feb.29 CohortStudiesII Dr.Jones-Bitton20 Mar.2 Case-ControlStudiesI Dr.Jones-Bitton21 Mar.4 Case-ControlStudiesII Dr.Jones-Bitton22 Mar.7 InterventionStudies:RandomizedControlledTrialsI Dr.D.Kelton23 Mar.9 InterventionStudies:RandomizedControlledTrialsII Dr.D.Kelton24 Mar.11 InterpretingMultivariableModels

40thClassDay–lastdaytodropone-semestercoursesDr.Jones-Bitton

25 Mar.14 MIDTERM2 --26 Mar.16 CriticalAppraisal Dr.Jones-Bitton27 Mar.18 InfectiousDiseaseModelling K.Spence28 Mar.21 MeasuresofDiseaseFrequencyI Dr.Jones-Bitton29 Mar.23 MeasuresofDiseaseFrequencyII Dr.Jones-Bitton-- Mar.25HOLIDAY–NOCLASS --30 Mar.28 EcosystemApproachestoHealth

GROUPASSIGNMENTDUEDr.S.Harper

31 Mar.30 StudyQuality-ReportingGuidelines Dr.J.Sargeant32 Apr.1 OutbreakInvestigationsI Dr.Jones-Bitton33 Apr.4 OutbreakInvestigationsII Dr.Jones-Bitton34 Apr.6 DiseaseSurveillance A.Swirski35 Apr.8 Review Dr.Jones-Bitton

Readings

AnoteregardingReadings:“needtoknow”topics(i.e.thosethatwillbeincludedinexaminations)arethosecoveredinclass.Thetextbookreadingsaremeanttohelpsolidifyorextendyourlearningandenableapplicationofthatmaterial.Assuch,theyarestronglyrecommended.Topicsthatarecoveredinthereadingsthatwerenottoucheduponinlecturewillnotbeconsidered“testable”material.

Session Topic&Notes Readings

1 IntroductiontoCourse --2 IntroductiontoEpi&HistoricalApproaches Chapter1,Gordistext3 FoundationsinHealth&DiseaseTransmission Chapter2,Gordistext4 FoundationsinHealth&DiseaseTransmission5 StatisticalAnalysisofEpidemiologicalData Reviewprevious

STAT*2040/otherSTATnotes

6 SamplingI Chapter8,Gordistext(uptop.160)7 SamplingII

8 Screening&DiagnosticTestsI Chapter59 Screening&DiagnosticTestsII10 EpidemiologyinPublicHealth --11 Bias&CausationI Chapters14&15,Gordis

text12 Bias&CausationII13 Assignment --14 MIDTERM1 --15 IntroductiontoObservationalStudies --16 MeasuresofAssociation Chapters11&12,Gordis

text17 Cross-SectionalStudies p.210–212,Gordistext18 CohortStudiesI Chapter9,Gordistext19 CohortStudiesII20 Case-ControlStudiesI Chapter10

(top.202)&Chapter13,Gordistext

21 Case-ControlStudiesII

22 InterventionStudies:RandomizedControlledTrialsI Chapters7&8,Gordistext23 InterventionStudies:RandomizedControlledTrialsII

24 InterpretingMultivariableModels40thClassDay–lastdaytodroponesemestercourses

Tripepietal.,2011(onCourselink)

25 MIDTERM2 --26 CriticalAppraisal Young&Solomonpaper

(onCourselink)

27 InfectiousDiseaseModelling Mishraetal.,2011(onCourselink)

28 MeasuresofDiseaseFrequencyI Chapter3,Gordistext29 MeasuresofDiseaseFrequencyII30 EcosystemApproachestoHealth Harperetal.,2012

Harperetal.,2011(onCourselink)

31 StudyQuality–ReportingGuidelines

Sargeant&O’Connor(onCourselink)

32 OutbreakInvestigationsI Reingoldpaper(onCourselink)33 OutbreakInvestigationsII

34 DiseaseSurveillance --35 Review --