1

DermaScan® C USBHigh Resolution Ultrasound

CORTEX TECHNOLOGY DENMARK

2CORTEX TECHNOLOGY DENMARK

DermaScan® CHigh Resolution Ultrasound

3

To obtain objective data

To visualize invisible changes and conditions

To learn more - faster

To help improve treatment and life quality for patients

To improve quality of products

To lower cost of product development

CORTEX TECHNOLOGY DENMARK

Ultrasound Measurements - Why?

Ultrasound Measurements - When?

Prior to therapy (e.g. tumors, port wine stains)

Follow-up (e.g. wound healing, tumors, port wine stains, aging)

To document product claims (cosmetics, pharma.)

To obtain accurate and reproducible data for basic research

4CORTEX TECHNOLOGY DENMARK

5

Ultrasound Measurements - Who?

In dermatology & plastic surgery (clinically, research)

Pharmaceutical industry

Cosmetic and aesthetic industry

Others - neuro medicine, wound healing, paediatrics, occupational medicine etc.

CORTEX TECHNOLOGY DENMARK

6

Ultrasound Applications include … Scientific skin research Irritancy/allergy testing Wound healing Collagen (photo damage, skin aging, skin rejuvenation) Cellulite (efficiency of treatment) Scleroderma, Psoriasis Tumors (basal cell, squamous cell, malignant melanoma …) Vascular lesions (port wine stains, hemangioma) Claims substantiation (cosmetics and pharma.)

CORTEX TECHNOLOGY DENMARK

Definition of Ultrasound

Frequency 20.000 Hz (20 kHz)

UltrasoundEchograpySonography

7CORTEX TECHNOLOGY DENMARK

Conventional Ultrasound

Conventional ultrasound: fmax < 10 MHz

+ High penetration+ Wide application range+ Wide price range

8CORTEX TECHNOLOGY DENMARK

- Low resolution

High Resolution Ultrasoundfor Skin Measurement

High resolution ultrasound: f = 20 MHz or higher

+ High resolution+ High definition

9CORTEX TECHNOLOGY DENMARK

- Low penetration- Limited to skin / subcutis

Send Ultrasound Pulse and listen for Echo

skin boundaries

10CORTEX TECHNOLOGY DENMARK

Skin

The basic Echo A-Scan

CORTEX TECHNOLOGY DENMARK 11

Transmitted pulse of ultrasound

Received signal (A-scan)

B-Scan image = 224 lines of A-Scan

12CORTEX TECHNOLOGY DENMARK

Prob

e

One image consists of 224 lines of ultrasound A-scan

The B-Scan Image

Normal face scan, young lady, near eye

13CORTEX TECHNOLOGY DENMARK

Epidermis Dermis Subcutis

Prob

e

Water Film Gel

In-depth penetration

Beam Focus is important for high Resolution

Sound beam Focal zone

Active element (x-tal)

Transducer housing

Skin surface

Water/gel path

14CORTEX TECHNOLOGY DENMARK

Skin

Resolution of B-Scan Image

Axial resolution (Rax) is determined by the sound velocity (v) and the system bandwidth (BW)

where BW ~ 75% of Fcrystal

E.g. 20MHz: v ~ 1580 m/s, BW ~ 0,75 * 20 MHz => Rax ~ 60 µm

50MHz: v ~ 1580 m/s, BW ~ 0,75 * 50 MHz => Rax ~20 µm

Lateral resolution is determined by the beam diameter (diameter determined by acoustic focusing)

typically 150 µm

BWvRax

2

15CORTEX TECHNOLOGY DENMARK

Higher ultrasound frequency higher band-width higher resolution

Penetration in to the Skin

Determined by focal distance (water/gel path)

Determined by attenuation (1 dB / MHz / cm)

16CORTEX TECHNOLOGY DENMARK

Higher ultrasound frequency lower penetration into the skin

Selection of ultrasound frequency is a trade-off between resolution and penetration

17

Nail foil – 20 MHz and 50 MHzNotice the higher resolution but lower penetration

in the 50 MHz image

CORTEX TECHNOLOGY DENMARK

DermaScan® C20 MHz <–> 50 MHz

18

DermaScan® C USB

CORTEX TECHNOLOGY DENMARK

2-D Ultrasound Imaging

19

DermaScan® C USB2-D Ultrasound Imaging

CORTEX TECHNOLOGY DENMARK

Prob

e

Normal skin

Mal

igna

nt

Mel

anom

aTh

in a

nd p

hoto

-age

d(S

tero

id a

trop

hy)

Scar

tiss

ue

20

DermaScan® C Compact3-D Ultrasound Imgaging

CORTEX TECHNOLOGY DENMARK

21

DermaScan® C Compact3-D Ultrasound Imaging

CORTEX TECHNOLOGY DENMARK

22

Some examples of Images

CORTEX TECHNOLOGY DENMARK

23

DermaScan® C2-D sample Images

Normal photo-aged skinNotice : The Collagen structure changes over time

(colors disappear over time)

20 years 30 years 40 years 50 years

CORTEX TECHNOLOGY DENMARK

24

DermaScan® C2-D sample Images

CORTEX TECHNOLOGY DENMARK

Cellulite After AHA peeling

25

Hemangioma in the face

CORTEX TECHNOLOGY DENMARK

DermaScan® C2-D sample Image

26

Scar tissue

CORTEX TECHNOLOGY DENMARK

DermaScan® C2-D sample Image

27

BCC, various body sites

CORTEX TECHNOLOGY DENMARK

DermaScan® C2-D sample Images

28

Measurements

CORTEX TECHNOLOGY DENMARK

29

Ultrasound BasicsMeasurement modes

Distance (A-scan, arbitrary, B-scan edge/peak detect.) Intensity (B-scan edge/peak detection, Region of Interest) Area (B-scan edge/peak detection, Region of Interest) Volume (3D-scan only)

CORTEX TECHNOLOGY DENMARK

30

DermaScan® CDistance Measurements

Insect bite

CORTEX TECHNOLOGY DENMARK

31

DermaScan® CIntensity Measurement

Insect bite

CORTEX TECHNOLOGY DENMARK

32

DermaScan® CArea Measurement

CORTEX TECHNOLOGY DENMARK

33

Thank You

for Your Attention

CORTEX TECHNOLOGY DENMARK