Date post: | 30-Dec-2015 |
Category: |
Documents |
Upload: | maisie-mcknight |
View: | 26 times |
Download: | 0 times |
Development of Cerebral Aneurysms. A Prediction Model
Ihor Machyshyn
Dr. Ir. P.M.J. Rongen (Philips Medical Systems)Dr. Ir. A.A.F. van de Ven (TU/e, W&I)Dr. Ir. S.J.L. van Eijndhoven (TU/e, W&I)Prof. Dr. Ir. F.N. van de Vosse (TU/e, BMT)Dr. Ir. P.H.M. Bovendeerd (TU/e, BMT)
Supervisors
3D Rotational Angiography (3D-RA)
Combined X-ray images into a 3D view
dangerous?
safe?
Approaches to assess risk of rupture
• Current clinical practice (based on geometry)
• Mechanical analysis:
– Hemodynamical approach
– Vessel wall mechanics
Stress and strain estimation
Adaptation of the tissue
Rupture criterion
Goal of the project
• Develop a model that uses realistic description of
aneurysmal tissue
• Study growth of cerebral aneurysms
Blood Vessel Histology
Model
elastin
collagen
rec - recruitment
cn - collagen thickness
a - attachment collagen stretch
Collagen
Elastin - elastin (tissue) stretch
Variables
c - collagen stretch
Equations Governing Mechanics
div 0 • Equation of equilibrium:
• Incompressibility equation: det 1F
• Constitutive equation:
1 1 1 2 2 2
1,
2e c f c c f c cp n e e e e I +
( ),e ec B - I 22 2 21 22 1 exp 1 ,fi ci ci cik k
X
x
F =,TB = FFwith
Evolution Equations of Remodeling
( ),recc a
d
dt
( )cc a
dn
dt
with , - rate constants of remodeling
• Equations of remodeling:
• Initial conditions
0 ,0( ) ( ),rec rect t x 0 ,0( )c cn t t n
Healthy State of an Artery
Transition between States
Remodeling to a Healthy State
Visualization of Instability
Stability of Equilibrium ((e)) States
Analysis of Stability of an Equilibrium State of a Thin-walled cylinder. Equations
2
4 2 2 2
( ) cos ( )11 ( ) ,
( ) sin ( ) cos ( )c
f ce
n t R pt
t H c
1 2 1 2( ) ( ) ( ), ( ) ( ) ( )c c c f c f c f ct t t t t t
0( ) ( ) ,c recn t t C
( )( ) ,
( )crec
tt
t
( )( )recc a
d tt
dt
22 2 212( ) 2 1 exp 1f c c c c
e
kk
c
where
Method
( )( ) ( ),et t ( )( ) ( ),e
rec rec rect t ( )( ) ( ),e
c c cn t n n t
( ) ( ) ( ), , ; ( ), ( ), ( )e e erec recn t t n t satisfy equations on the previous slide
const,p
0 state is, ,
0 state isaK p
stable
unstableStability condition:
Result