Diabetes Mellitus Type 2

Dr. Vinod Sanghi MD

Overview of Diagnosed and Undiagnosed Diabetes in the

United States—2000

Diabetes in India

People with Diabetes : 40 million

In 2025 : About 70 million people with diabetes

DIABETES CAPITAL OF THE WORLD

Diabetes Major impact on Morbidity & Mortality

Diabetes can lead to :

Coronary heart disease

Diabetic retinopathy

Diabetic neuropathy

Diabetic nephropathy

Diabetes Prevalence, 1990-2001

Diabetes is increasing in India

Fast food

Lack of exercise

Diabetes in India

Estimated Costs of Diabetes in the

United States—2002

Prevalence of Diabetes* in the United States According to Age

and Sex—2000

Estimated Prevalence of Diabetes in Global Adult Population—1995-2025

DCCT: Effects of Intensive vs Conventional Glycemic Control

UKPDS: Design

UKPDS: Effects of Intensive (Sulfonylurea/Insulin) Treatment

UKPDS: Effects of Intensive (Metformin)

Treatment*

UKPDS: Risk Reduction in Diabetes-

Related Complications (A1C)

UKPDS: Effects of Tight vs Less-Tight Blood Pressure

Control

The 4S Diabetes Substudy

The CARE Trial: Reduction of Coronary

Events in Subjects With and Without Diabetes

Evidence Supporting Multiple

Risk Factor Reduction

Multifactorial Intervention in Patients With Type 2 Diabetes:

Steno-2 Study—Design

Multifactorial Intervention in Patients With

Type 2 Diabetes: Steno-2 Study—Treatment Goals

Multifactorial Intervention in Patients With Type 2 Diabetes:

Steno-2 Study—CV Events

Pathophysiologyof Type 2 Diabetes

andInsulin Resistance

Insulin Resistance

Natural History of Type 2 Diabetes

Development of Type 2 Diabetes

Hyperglycemia in Type 2 Diabetes Results From Three

Major Metabolic Defects

Insulin Resistance: Associated Conditions

Standards of Care forGlycemia, Lipids, and Hypertension

2003 ADA Recommendations for Glycemic Control in Type 2

Diabetes

2003 ADA Lipid Targets in Type 2 Diabetes

2003 ADA Treatment Recommendations for

Hypertension and Nephropathy

NCEP: Diabetes as CHD Risk Equivalent

NCEP: Metabolic Syndrome

NCEP: Clinical Identification of the

Metabolic Syndrome*

(Indian : >35in) (Indian : >30in)

Diabetes Prevention Program: Reduction in Diabetes Incidence

Diabetes Prevention Program: Summary

AACE Guidelines for the Management of Type 2

Diabetes