DIAGNOSTIC IMAGING PROGRAM
NATIONAL CANCER INSTITUTE
National Institutes of Health
National Cancer Institute
Diagnostic Imaging Program
Diagnostic Imaging Program: Update
• Money• Organizational comments• Current Programs• Future Plans• Concluding comments
NIH Funding for Imaging
$0
$50
$100
$150
$200
$250
$300
$350
FY 96 FY 97 FY 98 FY 99
DIP
NIH-RAD
NIHImaging
$Millions
DIP Grant Funding
$0
$10
$20
$30
$40
$50
$60
$70
$80
FY 96 FY 97 FY 98 FY 99
$M
Diagnostic Imaging Program(DIP)
DiagnosticImagingBranch
FunctionalImagingBranch
Image-guidedTherapyBranch
Office ofImaging
Technology
Division of Cancer Treatment and Diagnosis(DCTD)
CancerDiagnosisProgram
(CDP)
Develop-mental
TherapeuticsProgram
(DTP)
CancerTherapy
EvaluationProgram(CTEP)
RadiationResearchProgram
(RRP)
NCI
Organization
• 10 FTE’s– D Sullivan, L Clarke, J Hoffman, A
Menkens, B Croft, M Torres, J Smith, L Cooley, S Bowles, L Banh
• 3 Part-time– E Staab, J Tatum, C Langlotz
• Further expansion is space limited
Positions available(of importance to imaging)
• NCRR Director of Bioengineering
• NHLBI Program Director
• NCI Scientific Review Administrator
Radiology 1999; 212:609-614
Recent Programs
Programs Awards AmountRFA: CA-97-020:Cooperative Trials inDiagnostic Imaging (ACRIN)
2 U01 $ 3.0 M yr. 1$ 22 M Tot
RFA: CA-98-024:Development AndApplication of Imaging InTherapeutic Studies
9 R01’s $ 2.8 M yr. 1$ 11.6 M Tot
CA-98-023: Small AnimalImaging Resource Programs(SAIRPs)
5 U01’s $ 5.3 M yr. 1$ 15.3 M Tot
Current Programs(1)
Program Awards AmountRFA: CA –99- 002 – PlanningGrants – Molecular andCellular Imaging Centers (Pre-ICMICs):
6-8 P20’s $ 2.4 yr. 1$ 7.2 M Tot
RFA: CA –99- 004: Molecularand Cellular Imaging Centers:(ICMICs)
2 P50’s peryear
$4.0 M yr. 1$48.0 M Tot
RFA CA-99-015: DiagnosticImaging and Guided Therapyin Prostate Cancer (PhasedInnovation Award)
6-8 R21/R33 $1.6 M yr.1$13.6Tot
PAR-99-149: DiagnosticImaging and Guided Therapyin Prostate Cancer:SBIR/STTR Initiative
R43/R44 Payline
Current Programs(2)Program Awards AmountPA: 99-082/ 083: Development and Testing ofDigital Mammography Displays and Workstations
R0I/ SBIR/STTR). Payline
PA: 98-008: Exploratory/Developmental Grants forDiagnostic Cancer Imaging
R21’s $5.7 M yr. 1
PAR-99-101: Innovative Technologies for theMolecular Analysis of Cancer: Phase InnovationAward
R21/R33 SBIR/STTR(PAR-99-100)
Payline
PAR-99-102: Applications Of InnovativeTechnologies For The Molecular Analysis OfCancer: Phased Technology Application Award
R21/R33 SBIR/STTR(PAR-99-103)
Payline
PAR-99-010: Bioengineering ResearchPartnership Programs (BRP)
R01’s Payline
PAR-99-009: Bioengineering Research Grants(BRG)
R01’s Payline
BAA No. N01-CM-97065-32 Novel Technologies forNoninvasive Detection, Diagnosis and Treatmentof Cancer
Contracts $ 4 M yr.1$16 M Tot
Collaborative Programs
Program Awards Amount
PA 98-092: Shared Resources forScientists Outside NCI Cancer Centers
R01 or P01 Payline
NLM 99-103: Visible Human ProjectImage Processing Tools (NLM)
Contracts
RFA: AI-99-004: New ImagingTechnologies For Autoimmune Diseases
R01’s $3.5 M yr. 1$17.5 M Tot
RFA: CA-99-013: Cancer Intervention andSurveillance Modeling Network (CISNET)
U01’s $1.5 M yr. 1$6.0 M Tot
CTEP Collaborative Programs
Program Awards
CTEP Protocol Review ContractsU01’s
CA-98-007: Pediatric Brain Tumor ClinicalTrials Consortium
U01, imagingrequired
RFA for new Centers U54’s imagingrequired
RFP for Phase I & II clinical trials Contracts imagingrequired
DIP Standards Activities
• DICOM / Working Group on Clinical Trials Data
• RSNA - IHE / RSNA - image archive collaborations
• Structured reporting collaborations: DICOM, SNOMED, ACR, RSNA
• Image database standards: RFA
NCI - Imaging Industry Relations Forum
• Clear description of HCFA decision rules
• Policy for conditional coverage of emerging imaging technologies
• Re-evaluation of FDA policies, esp. re: tracers or procedures of low risk
• Assure full range of NCI support mechanisms for imaging science.
NCI Training Activities
R 25Cancer Education and Career Development
Program
R 25 Cancer Education and Career Development Program
• Multidisciplinary
• Institutional award
• Salary support for PI and core faculty
• Trainee salary up to $75,000
• Research support up to $20,000 per trainee
• 5 yr. grant, renewable
• 8% indirect
K07 / K08 / K23
• K 07 Epidemiology
(limited use by radiology)• K 08 Clinician: Bench science
(limited use by radiology)• K23 Clinician: Patient-oriented (hands-
on; obtain consent form)
(no imaging applications yet)• Salary $75,000/ Research $30,000
T32 Training Grants - Imaging
From 1/97-10/99 (6 NCI deadlines)
• 6.5% of applications submitted were imaging-related
• 57.1% of imaging-related T32s were funded
• 54.2% of T32 applications submitted to NCI were funded
T32 Training Grants - Imaging
Yrs PI Title 24 Kuhl, David Cancer Research Training in Nuclear Medicine 17 Wagner, Henry Res. Training in Use of Tracer Principles in Oncology 14 Brady, Thomas Nuclear Magnetic Research 10 Zerhouni, Elias Research Training in Oncology Imaging 7 Glazer, Gary Advanced Techniques for Cancer Imaging 5 Clouse, Melvin Deaconess Research Training in Cancer Radiology 4 Baum, Stanley Training in Innovative Cancer Imaging Technologies 3 Hawkins, Randall Research Training in Diagnostic Oncology 2 Wehrli, Felix Training in Quantitative Magnetic Resonance Imaging
23 Hoffman, Edward Research Training in Biomedical Physics 23 Bedford, Joel Radiological Sciences Basic to Cancer Research 21 DeLuca, Paul U.W. Radiological Sciences Training Program 18 Alpert, Nathaniel Postgraduate Program in Radiological Science 10 Doi, Kunio Research Training in Medical Physics
Future Plans - Devices
• Proposed PA: R21/R33 for imaging technology development
• RFP for ultrasound research interface• RFA for spiral CT image database• Proposed program to support production
of beta units for clinical trials• Proposed additional Centers with
technology development component
Future Plans - Pharmaceuticals (Imaging agents)
Pharmaceutical categories of interest:– 1. Non-PET tracers– 2. PET tracers– 3. Bulk agents (pharmacologic effect)– 4. Radiolabeled therapeutic agents
(non-sealed-source agents)
Future Plans - Pharmaceuticals (Imaging agents)
• Proposed program to support development of novel imaging probes.
• Proposed program to support R & D necessary for IND, and provide supply needed for clinical trials.
Concluding Comments
• Molecular imaging is future priority
• DIP funding increased 40 %
• More applications lead to more funding
• Patient accrual needs attention
• Rewards for team science need attention
• Think R25 for research training grants
Sources of NCI imaging information to public
• Website: URL = www.nci.nih.gov/dip/
• Email Newsletter
Handouts available
• URLs of interest
• Training program information
• Copy of Acad Rad article: Radiologic Sciences Research in the Next Century
• DIP Newsletter
• Everything you ever wanted to know …
• Cancer information pamphlets