DIFFERENTIAL COMPONENTS OF PROSPECTIVE MEMORY? EVIDENCE FROM FMRI
J. Simons, M. Scholvinck, S. Gilbert, C. Frith, P. Burgess
By Alex Gustafson
WHAT IS PROSPECTIVE MEMORY? Remembering to perform an action after a delay Event-based PM – 2 components:
Cue identification Intention retrieval
BEHAVIOURAL VS. COGNITIVE DIFFERENCES Behaviour:
Cue identification is stimulus driven Intention retrieval is conceptually driven
Do the two different behaviours rely on the same brain areas? The anterior prefrontal cortex (Brodmann area 10) is activated
during PM tasks Cue identification and intention retrieval have not been previously
separated experimentally to test activation It is expected that the anterior prefrontal network supports PM
function regardless of the demands on each process
EXPERIMENT Subject-paced “Uncontaminate
d” trials (x2) “Contaminated”
trials (x4) Unrelated task X X X X Word and shape
tasks were used to determine activation based on PM
X XX
RESULTS Reaction Time
Uncontaminated < Contaminated ongoing trials Cue identification < Intention retrieval
Neuroimaging Consistent pattern of activation in:
Anterior prefrontal, ventrolateral prefrontal and lateral parietal cortex Lateral BA 10 activated Medial BA 10 deactivated Differential BA 10 involvement:
RESULTS Cue identification:
Medial BA 10 more activated Anterior cingulate
Intention retrieval: Lateral BA 10 more activated Dorsolateral prefrontal cortex and orbitofrontal cortex Cingulate gyri Precuneus
FMRI RESULTS
DISCUSSION BA 10 is of central importance to prospective memory
The experimental conditions were not exclusive, however behavioural effects were seen
Behavioural differences could not explain hemodynamic changes
DISCUSSION Lateral BA 10 activation increased due to attention to
internal representations of what must be retrieved from memory Context
Medial BA 10 involved in attention towards external events
Overall role of BA 10: A “gateway” between cognitive process needed to detect perceptual
information and derive intention
OPINION Introduction was well written; good background
Clear results Further correlational study helped to solidify findings
Huge amount of detail in the methods section
Tables may be useful if conducting a further study, but were not clearly interpreted
STRENGTHS AND LIMITATIONS
Strengths Limitations fMRI showed clear results
Easy to follow
Analyzed many aspects giving more comprehensive results yet stayed focused
Extensions from results were limited
Could not fully separate cue identification and intention retrieval conditions
FUTURE EXPERIMENTS Vary age of participants
All 16 subjects were 18-30 Differences in older people or people with PM loss?
Manipulate actions that require external and internal attention Do activities requiring reaction to external stimuli necessarily
depend on BA 10 as a gateway? Implicit memory task
SUMMARY BA 10 is central to PM functioning
Cue identification vs. intention retrieval behaviourally distinct share a common neural basis
Cue identification is largely dependent on external stimuli Higher medial BA 10 activation
Intention retrieval is more cognitively demanding Increased lateral BA 10 activation
QUESTIONS?