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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell...

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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma Bjoern Chapuy, Michael R. McKeown, Charles Y. Lin, Stefano Monti, Margaretha G.M. Roemer, Jun Qi, Peter B. Rahl, Heather H. Sun, Kelly T. Yeda, John G. Doench, Elaine Reichert, Andrew L. Kung, Scott J. Rodig, Richard A. Young, Margaret A. Shipp,* and James E. Bradner* *Correspondence: [email protected] (M.A.S.), [email protected] (J.E.B.) http://dx.doi.org/10.1016/j.ccr.2014.03.029 (Cancer Cell 24, 777–790; December 9, 2013) Following publication of the manuscript, the authors identified an inadvertent error in labeling of the H3K27ac ChIP-Seq tracks at the PAX5 locus in Figure 7E. The revised Figure 7E, shown below, includes the correctly labeled H3K27ac tracks of the PAX5 locus in the indicated cell lines and normal tissue control (tonsil) and illustrates the presence of a PAX5 super-enhancer in each of these cell lines and tonsil. The conclusions remain the same. Cancer Cell Errata Cancer Cell 25, 543–548, April 14, 2014 ª2014 Elsevier Inc. 545
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Cancer Cell

Errata

Discovery and Characterizationof Super-Enhancer-Associated Dependenciesin Diffuse Large B Cell LymphomaBjoern Chapuy, Michael R. McKeown, Charles Y. Lin, Stefano Monti, Margaretha G.M. Roemer, Jun Qi, Peter B. Rahl,Heather H. Sun, Kelly T. Yeda, John G. Doench, Elaine Reichert, Andrew L. Kung, Scott J. Rodig, Richard A. Young,Margaret A. Shipp,* and James E. Bradner**Correspondence: [email protected] (M.A.S.), [email protected] (J.E.B.)

http://dx.doi.org/10.1016/j.ccr.2014.03.029

(Cancer Cell 24, 777–790; December 9, 2013)

Following publication of the manuscript, the authors identified an inadvertent error in labeling of the H3K27ac ChIP-Seq tracks at the

PAX5 locus in Figure 7E. The revised Figure 7E, shown below, includes the correctly labeled H3K27ac tracks of the PAX5 locus in the

indicated cell lines and normal tissue control (tonsil) and illustrates the presence of a PAX5 super-enhancer in each of these cell lines

and tonsil. The conclusions remain the same.

Cancer Cell 25, 543–548, April 14, 2014 ª2014 Elsevier Inc. 545

Lead

ing

Edge

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UP IN GCB_VS_PC0

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JQ1DMSO

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ad [x

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H3K

27ac

load

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B

C

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Tonsil

Enhancers ranked by increasing H3K27Ac signal

1

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PAX5OCA-B

12,0004,0000H3K

27ac

load

[x10

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4

8,0000 4,000

2

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Ly3

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I

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Figure 7. Comparative SE Analysis of DLBCL Cell Lines and Normal Lymphoid Tissue

Cancer Cell

Errata

546 Cancer Cell 25, 543–548, April 14, 2014 ª2014 Elsevier Inc.


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