Cancer Cell
Errata
Discovery and Characterizationof Super-Enhancer-Associated Dependenciesin Diffuse Large B Cell LymphomaBjoern Chapuy, Michael R. McKeown, Charles Y. Lin, Stefano Monti, Margaretha G.M. Roemer, Jun Qi, Peter B. Rahl,Heather H. Sun, Kelly T. Yeda, John G. Doench, Elaine Reichert, Andrew L. Kung, Scott J. Rodig, Richard A. Young,Margaret A. Shipp,* and James E. Bradner**Correspondence: [email protected] (M.A.S.), [email protected] (J.E.B.)
http://dx.doi.org/10.1016/j.ccr.2014.03.029
(Cancer Cell 24, 777–790; December 9, 2013)
Following publication of the manuscript, the authors identified an inadvertent error in labeling of the H3K27ac ChIP-Seq tracks at the
PAX5 locus in Figure 7E. The revised Figure 7E, shown below, includes the correctly labeled H3K27ac tracks of the PAX5 locus in the
indicated cell lines and normal tissue control (tonsil) and illustrates the presence of a PAX5 super-enhancer in each of these cell lines
and tonsil. The conclusions remain the same.
Cancer Cell 25, 543–548, April 14, 2014 ª2014 Elsevier Inc. 545
Lead
ing
Edge
low high
Ly1JQ1 S-
DHL6S-
Ly4S-
ToledoS-
HBL1S-
gg
AICDA
p=.007
UP IN GCB_VS_PC0
-0.6
JQ1DMSO
H
AH
3K27
ac lo
ad [x
105 ]
H3K
27ac
load
[x10
5 ]
B
C
D
H3K
27ac
load
[x10
5 ]
Tonsil
Enhancers ranked by increasing H3K27Ac signal
1
2
PAX5OCA-B
12,0004,0000H3K
27ac
load
[x10
5 ]
4
8,0000 4,000
2
DHL6
OCA-BPAX5
8
12,0000 6,0000
4
Ly1OCA-B
PAX5
15,0000 5,000
5
3
Ly3
1
OCA-B
12,0000 6,000
6
3
OCA-B
PAX5
HBL1
4
15,0000 5,000
2
OCA-B
PAX5
3
14,0000 6,000
1
3
Ly4
OCA-B
PAX5
PAX5
G
0.8 0.0Distance
Ly4
Ly1
DHL6
Toledo
Ly3
HBL1
1.0Correlation
0.60.2
Ly4
Ly1
DH
L6
Tole
do
Ly3
HB
L1
F
I
IRF4IRF4
IRF8 IRF8
IRF8
IRF8
IRF8IRF8
IRF4
IRF8
IRF4 Ly1
DHL6
Ly3
HBL1
50 kb7
7
7
7
chr6:219,860 chr6:482,592
IRF4DUSP22
ES
ChI
P-S
eq [r
pm/b
p]Toledo
E LY1
DHL6
LY3
HBL1
Toledo
LY4
50kb
10
10
10
10
10
10
chr9:37,050,000 chr9:36,900,000
PAX5
Tonsil10
ChI
P-S
eq [r
pm/b
p]
Figure 7. Comparative SE Analysis of DLBCL Cell Lines and Normal Lymphoid Tissue
Cancer Cell
Errata
546 Cancer Cell 25, 543–548, April 14, 2014 ª2014 Elsevier Inc.