Bestpharma was founded in pursuit of excellence. By focusing all of
our attention on the customers' needs and by meeting all their
expectations we were able to stabilize our position and have gained
the trust of major manufacturers of pharmaceuticals and dietary
supplements in Poland.
At Bestpharma we believe that high quality shouldn't be
accompanied by high prices. Thanks to diversifying our suppliers and
effective negotiation, we deliver highest quality products sustaining
reasonable prices. The quality of customer relations is also one of the
reasons why companies choose us as a partner. We work with the
customer to best fit his needs and meet his expectations.
Bestpharma supplies and distributes standard pharmaceutical
ingredients as well as specialized products. Our Pharma-targeted
approach obligates us to take very restrictive measures in quality
assessment of our products and constant engagement in customer
relations. We are well aware that in many cases the well-being of
patients undergoing pharmaceutical treatment and dietary
supplements consumers depends on our professionalism. This is why
we give all the attention to deliver repeatedly reliable quality (RRQ)
We are a dynamic company with a stable position on the polish
pharmaceutical and nutraceutical ingredients market. Thanks to
intense R&D efforts, we’ve lately released our own product, BestCoat
film coating systems which is being produced in Poland. Our goal is
expansion on both Polish and European markets. Our team devotes
itself to building strong and both ways beneficial relationships with
customers. This is why we based our trade and distribution structure
on observance of the law and ethics in trading by always fulfilling
commitments we undertake.
The catalog you are holding represents the effects of a successful cooperation with our customers.Please note, we are always open to new assignments and challenges. If the
desired product cannot be found in this catalogue, please contact us at:
[email protected] We will do our best to help.
3
06 Bestpharma ExcipientsQuality IS ESSENTIAL
12 Bestpharma NaturalNATURAL EXTRACTof the world
20 Bestpharma ProBioANAEROBIC PROBIOTICSThe next step in gut health
28 Bestpharma MarineNATURAL MARINE and PLANT OILSand Omega 3 products
36 Bestpharma BestCoatInnovative Film Coating SystemsFOR FOOD AND PHARMA
TABLE OFCONTENTS
5
EXCIPIENTS
Excipients are pharmacologically inactive substances formulated with the
active ingredient (API) of a medication. They are commonly used to bulk up
formulations that contain potent active ingredients (thus often referred to as
"bulking agents," "fillers," or "diluents"), to allow convenient and accurate
dispensation of a drug substance when producing a dosage form. They also can
serve various therapeutic-enhancing purposes, such as facilitating drug
absorption or solubility, or other pharmacokinetic considerations. Excipients
can also be useful in the manufacturing process, to aid in the handling of the
active substance concerned such as by facilitating powder flowability or
non-stick properties, in addition to aiding in vitro stability such as prevention of
denaturation over the expected shelf life. The selection of appropriate
e0xcipients also depends upon the route of administration and the dosage
form, as well as the active ingredient and other factors.
At Bestpharma we believe that the key to a successful formulation is a high
standard and repeatable high quality. This is why we are proud to introduce our
state-of-the art excipients:
BESTCEL - Microcrystalline cellulose,
Magnesium Stearate
PHARMELLOSE - Croscarmellose Sodium
Pregelatinized Starch 1500
7
PRODUCT GRADE
GRADE PARTICLE SIZE DISTRI BUTION
D10(MIC)
D10(MIC)
D10(MIC)
ASP#(MIC)
BULKDENSITY(GM/ML)
MOISTURE(% W/W)
DOP##
DESCRIPTION
BESTCEL-101*
BESTCEL-102*
BESTCEL-103BESTCEL-112BESTCEL-113
BESTCEL-105
BESTCEL-200
BESTCEL-301
BESTCEL-302
BESTCEL-N
Most widely used for direct compression tableting and wet granulation.
Has similar compression properties to BESTCEL-101. However, it has larger particle size and therefore, may be of value in improving the flow if fine powders.
Reduce moisture content and are ideal for use with moisture sensitive materials.
Has the finest particle size and may be used in direct compressin of coarser, granular and crystalline materials. BESTCEL-105's enhanced compressibility characteristics make it ideally suitable for application involving difficult to compress materials. It can be admixed with BESTCEL-101 or BESTCEL-102 to achieve specific flow and/or compression properties.
Has a large particle size which offers increased flow ability with minimum effect on compression characteristics. It can be used in direct compression and wet granulation to reduce table weight variation and to improve content uniformity.
Has a higher density then its size equivalent, BESTCEL-101, providing increased flow ability, greater tablet weight uniformity and the potential for making smaller tablets.
Has the density characteristics of BESTCEL-301 with a particle size of BESTCEL-102. Like BESTCEL-301, BESTCEL-302 offers increased flow ability, greater tablet weight uniformity and the potential for smaller tablets.
Is most widely used for wet granulation.
1
2
345
6
7
8
9
10
BESTCEL-101BESTCEL-102BESTCEL-103BESTCEL-105BESTCEL-112BESTCEL-113BESTCEL-200BESTCEL-301BESTCEL-302BESTCEL-N*
NMT 30
NMT 45
NMT 30
—
NMT 45
NMT 30
NMT 70
NMT 30
NMT 45
NMT 30
40-60
70-100
40-60
—
70-100
40-60
150-200
40-60
70-100
40-60
NLT 80
NLT 140
NLT 80
—
NLT 140
NLT 80
NLT 260
NLT 80
NLT 140
NLT 80
50
90
50
20
90
50
180
50
90
50
0.26-0.32
0.27-0.33
0.26-0.31
0.20-0.30
0.28-0.35
0.26-0.34
0.31-0.39
0.34-0.45
0.35-0.46
0.25-0.45
3.0-5.0
3.0-5.0
1.0-3.0
1.0-5.0
0.0-5.0
0.0-1.5
0.0-2.0
3.0-5.0
3.0-5.0
NMT 5.0
200-250
200-250
200-250
200-250
200-250
200-250
200-250
130-180
130-180
200-250
1
2
3
4
5
6
7
8
9
10
*BECTCEL 101 and 102 are in stock throughout the whole year in our warehouse in Warsaw.
* Non-direct compressible grade BESTCEL-MCC# Average Particle Size, ## Degree of Polymerization, NMT : Not more than, NLT : Not less than, MIC : Micron
BESTCELLMICROCRYSTALLINE CELLULOSE
PROPERTIES OF DIFFERENT BESTCEL GRADES:
8
MAGNESIUM STEARATE
It has the chemical formula Mg(C18H35O2)2. It is a salt containing two
equivalents of Stearate (the anion of Stearic Acid and one Magnesium
cation (Mg2+). Magnesium Stearate melts at about 120 °C, is not
soluble in water, and is generally considered safe for human
consumption at levels below 2500 mg/kg per day. Magnesium Stearate
is often used as a diluent in the manufacture of medical tablets,
capsules and powders. In this regard, the substance is also useful,
because it has lubricating properties, preventing ingredients from
sticking to manufacturing equipment during the compression of
chemical powders into solid tablets; magnesium stearate is the most
commonly used lubricant for tablets.
Benefits of Bestpharma Magnesium Stearate:
It is an inactive ingredient that binds the active ingredient in a pill or capsule
The FDA classifies Magnesium Stearate as a glidant, or granulating agent.
Magnesium Stearate functions in medicine by preventing the different molecules used to make up the medicine from clumping together, thus ensuring that the correct dose is achieved in every pill made.
It is added to supplements to increase production speed as the machines fill the supplement capsules.
As an excipient, Magnesium Stearate helps to prolong the shelf life of pharmaceuticals and masks the taste and odour of active ingredients.
9
PHARMELLOSECROSSCARMELLOSE SODIUM
Croscarmellose sodium is an internally cross-linked sodium
carboxymethylcellulose for use as a superdisintegrant in
pharmaceutical formulations. It’s cross-linking reduces water solubility
while still allowing the material to swell (like a sponge) and absorb
many times its weight in water. As a result, it provides superior drug
dissolution and disintegration characteristics, thus improving formulas
subsequent bioavailability by bringing the active ingredients into better
contact with bodily fluids. Croscarmellose sodium also resolves
formulators concerns over long-term functional stability, reduced
effectiveness at high tablet hardness levels, and similar problems
associated with other products developed to enhance drug dissolution.
Croscarmellose sodium is a very commonly used pharmaceutical
additive approved by the European Food Safety Authority (EFSA). Its
purpose in most tablets – including dietary supplements – is to assist
the tablet in disintegrating in the intestinal tract at the required
location. If a tablet disintegrating agent is not included, the tablet could
disintegrate too slowly, in the wrong part of the intestine or not at all,
thereby reducing the efficacy and bioavailability of the active
ingredients.
Benefits of Bestpharma’s PHARMELLOSE Crosscarmellose Sodium:
Rapid disintegrator in pharmaceutical formulations for tablets, capsules and granules.
Effective for combination with both insoluble and filler-binders, such as MCC and DCP.
It can also be preferred for non starch base formulation product.
Tablet dissolution can be greatly increased by the use of a super disintegrant.
Efficient for low use of levels.
Insensate hardness of tablet.
Finer dissolution stability for long term.
Used in solid dosages vitamin and nutrition.
10
PREGELATINIZEDSTARCH 1500Starches are used in the pharmaceutical industry for a wide variety of
reasons, such as an excipient, a tablet and capsule diluent, a tablet and
capsule disintegrant, a glidant, or as binder. Disintegrants enable
tablets and capsules to break down into smaller fragments (dissolve) so
that the drug can be released for absorption. Starches also absorb
water rapidly, allowing tablets to disintegrate appropriately.
Pregelatinized Starch 1500 Conforms to USP27 standards.
Character: White powders, no smell, tasteless, insoluble in Organic solvents, parts dissoluble in cold water.
Particle size: 100 percent through 80 mesh sieve.
pH
Loss on drying [%]
Ash [%]
Iron [%]
Sulfur dioxide [%]
Oxide [%]
4.5-7.0
≤14.0
≤0.5
≤0.002
≤0.008
≤0.002
PHYSICAL PROPERTIES:
I T E M S P E C I F I C A T I O N ( U S P 2 7 )
11
NATURAL EXTRACTS
Natural extracts are ingredients derived from natural sources, mostly plants,
but also fungi, insects or animals. Plant extracts divide into flower, fruit, root,
bark derived and others depending on the functional substances in them.
Among others, flavonoids, saponins, tannins, essential oils, mucus and
vitamins were proven to have functional properties for the human organism.
Natural extracts are very well used in the Food Industry as well as in
Pharmaceuticals.
Bestpharma supplies a wide range of natural extracts which originate from all
over the world. Below you will find a list of our offered products. If your desired
extract is not on the list, do not hesitate to contact us at
[email protected]. We can surely help.
13
EXTR
AC
TSPLANT SOURCE BOTANICAL NAME SPECIFICATION
5-HTP
Acai Berry
Acerola Cherry
Achyranthes aspera
Astaxanthin
Akebia Stern
Alisma orientale
Aloe Vera
American Ginseng
Amorni Semen
Andrographis
Angelica polydada
Apple
Artichoke
Asarum
Astragalus
Avena Sativa
Bamboo Leaf
Basket fern
Bayberry
Beta Carotene
Bistort Rhizome
Bitter melon
Black Bean
Black Cohosh
Black Fungus
Black Pepper
Black Tea
Blackcurrant
Black Rice
Bladderwrack
Blueberry
Bran Oil
Broccoli
Bromelain
Buckwheat
Bupleurum
Burdock
Cactus
Calyx Kaki
Griffon ia simplicifolia
Euterpe badiocarpa.L
M alp ighia glabra L.
Achyranthes aspera L
Haematococcus pluvialis
Akebia trifotiata ( Thunb. >
Alisma o rien talis (Sam.)
Aloe vera L.
Panax quinguefoiium
Amomum viltosum Lour
Andrographis paniculate
Notopterygium incisum Ting
Mains Pumila
Cynara Scolymus
Asarum sieboldii Miq.
Astragalus Membranaceus
Avena sativa L.
Phyilostachys nigra Munro var.
Cyrtomium fortunei J. Sm.
Myrica rubra (L our,}
Carrot
Polygonum bistorta L .
Momordica charantia L
Glycine max(L.) Merr.
Cimicifuga racemosa
Auricularia auricula
Piper nigrum I.
Camellia sinensis O. Ktze.
Ribes nigrum L.
Oryza satiual
Fucus vesiculosusL.
Vaccinium Spp.
Bran oil
Brassica Oleracea
Ananas comosus
Fagopyrum Mill
Radix Bupteuri
Arctium lappa L
Opuntiadillenii
Diospyros kaki L f.
20%, 98%, 99% 5-HTP
l-25% Anthocyanidins, 10:l, 20:l
17% VC
10:1, 20:1
2-10% Astaxanthin
10:1, 20:1
10:1, 20:1
10:l, 25:l, 100:l, 200:l (Spray Dried or Freeze Dried)
10%-80% Ginsenosides
10:1, 20:1 10-95% Andrographolides, 8%
Dehydroandrographolide
10:1, 20:1
10%-80% Polyphenols, 20%-98% Phloridzin
2.5%,5% Cynarine, 10:l
10:1, 20:1
50-70% Polysaccharides, 5-98% Astragaloside IV
60%, 70% Beta Glucans
10%, 15%, 24% Bamboo flavone, 10:l
10:1,20:1
10:1,20:1
1-96% Beta Cartotine
10:1,20:1
10-80% Charantin/10%,20% Sapogenins, 10:1
5%,10%,15% Anthocyanidins
2.5%,5% Triterpene Glycosides
10%-40% Polysaccharides
20:1
20%-60% Theaflavine, 20%-90% Polyphenols
l%-25% Anthocyanidins,10:l,20:l
l%-25% Anthocyanidins,10:l,20:l
0.1% Iodine
1-36% Anthocyanidins
99% Oryzanol
0.6%,10%,20% Sulforaphane
2500GDU/g
10:1,20:1,5% D-Chiro Inositol
10:1
10:1,20:1
10:1,20:1,100:1
10:1,20:1
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
14
EXTR
AC
TSPLANT SOURCE BOTANICAL NAME SPECIFICATION
Cat's Claw
Catgrass
Cayenne
Celery
Celery Seed
Chamomile
Chaste Berry
Chaste Tree
China Dodder
Chinese angelica
Chinese Bilberry
Chinese catalpa bark
Chinese Foxglove
Chinese White Olive
Chinese yam
Chokeberrry
Chondroitin Sulfate
Chrysanthemum
Cinnamon
Citus Aurantium
Cleavers
Cloves
Cocoa
Coix Seed
Common Cnidium Fruit
Common Leafflower Herb
Coprinus Comatus
Coptis
Cordyceps
Conolus Mushroom
Corn Silk
Corydalis bungeana
Cranberry
Curcumin
Dandelion
Desertliving Cistanche
Devil's Claw
Ecdysone
Echinacea Angustifolia
Echinacea Purpurea
Uncaria Tomentosa
Agropyron cristatum
Capsicum annuum Linn
Apium graveoiens
Apium graveotens
Matricaria Recutita
Vitex agnus-castus Linn.
Vitex Agnus Castus
Cuscuta chinensis Lam.
Angelica Sinensis
Vaccinium uliginosum
Cataipa Ovata G.Don
Rehmannia giutinosa
Canarium album Raeusch.
Dioscorea opposita
Aronia nwianocarpa
Bovine Ca/tttage
Dendranthema niorifolium
Cortex Cinnamomi Cassiae
Citrus Aurantium
Galium aparine L.
Syzygium aromaticum
Theobroma Cacao
Semen Coicis
Cnidium monnieri (L.)
Phyltanthus urina-ria L.
Coprinus Comatus
Coptis chinensis Franch
Cordyceps sinensis
Coriotus versicolor
Zeamays L.
Co/ydalis bungeana Turcz.
Vaccinium macrocarpon.
Curcumin Longa
Taraxaci Officinale
Cistanche deserticola Ma
Harpagophytum Procumbens
Cyanotis arachnoisea
Echinacea Angustofolia
Echinacea Purpurea
3% Alkaloids
10:1,20:1
10:1,20:1
10:1,20:1
10:1,20:1
1% Total Apigenins
0.5% Agnusides
5% Vitexin,2% Agnuside
10:1,20:1
1% Ligustilides
1-36% Anthocyanidins
10:1,20:1
10:1,20:1
10:1,20:1
8%,16%,95% Diosgenine,10:l,20:l
10-25% Anthocyanidins,10:l,20:l
90% Chondroitin Sulfate
0.8% Lactone,10:l,15:l,20:l
10:1,20:1
6-98%Synepherine
10:1,20:1
4:1,10:1
10:1,20:1
10:1,20:1
20%,30%,50%,90%,98% Osthole
10:1,20:1
10%-40% Polysaccharides
5%,10% Alkaloids
10-40% Polysaccharides
10-40% Polysaccharides
10:1,20:1
10:1,20:1
l-36%Anthocyanidins,10:l,20:l,34:l,36:l
95% Curcumin
20% Taraxasterols,3% Flavonoids
10:1,20:1
1.5%, 3% Harpagosides
90%,95%,98% Ecdysone
4% Echinacosides
4% Phenolics.2%,4% Cichoric Acid
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
15
EXTR
AC
TSPLANT SOURCE BOTANICAL NAME SPECIFICATION
Elderberry
Elecampane
Emodin
Eucommia Bark Liquid
Eucommia Leaf
European Bilberry
Eurycoma Longifolia
Evening Primrose
Evodia
Fennel Seed
Fenugreek Seed
Ferulic Acid
Feverfew
Fig
Flaxseed
Flos Inulae
Forskohlin
Fo-Ti
Frankincense
French Maritime Pine Bark
Fructus Chaenomelis
Fructus Mori
Galanthamine
Gallnuts
Garcinia Cambogia
Gardenia
Garlic
Gastrodia Tuber
Ginger
Ginkgo FJiloba
Ginseng
Glabrous GreenbrierRhizome
Glucomannan
Goji Berry
Golden Rod
Goldenseal
Gotu Kola
Grape Seed
Grape Skin
Sambucus nigra L
Inula helenium L
Polygonum Cuspidatum
Eucommia Utmoids Otiv.
Eucommia Ulmoids Otiv.
Vaccinium Myrtilius
Eurycoma Longifolia
Oenothera erythrosepala Sorb.
Evodia Rutaecarpa
Fo eniculi Fructus
Semen Trigoneltae
Ferula assafoetida L.
Tanaceum parhenium
Ficus carica Linn.
Linum usitatissimum
inula britannica L
Coleus Forskohlii
Polygonum multlflorum Thunb
Bosweltia carteriiBirdw.
Pinus pinaster
Chaenomeles sinensis Koehne
Morus alba L
Lycoris radiata
Gallnuts
Garcinia Hanburyi
Gardeniajasminotdes Fills
Allium Sativum L
Gastrodia eiata
Zingiber Officinale
Ginkgo Btloba
Panax Genseng
Smitax glabra Roxb.
Amorphophaittus Konjac
Lyclum Chlnense
Solidago decurrens Lour
Hydrastis canadensis
Centetla As tat tea
Vttls Vtnlfera
Vitis Vintfera
10:1,20:1,5% Anthocyanidins
10:1,20:1
98% Emodin
Brix65
5-98% Chlorogenic Acid,10:l,20:l
1-25% Anthocyanidins
25:1,50:1,100:1,200:1
10:1,20:1
10% Evodiamines, 10:1,20:1
15:1
10%-50% Saponins,l%,5%,10%,20%4-Hydroxyisoleucine
98% Ferulic Acid
0.8% Pharthenolide
10:1,20:1
20%-80% Lignans (SDG)
10:1,20:1
10%,20%,98% Forskohlin
2% Phosphatide,10:l,20:l
10:1,20:1
95% Proanthocyanidins
10:1,20:1
10:1,20:1
98% Galanthamine Hydrobrmide
85%,90% Gallic Acid,85%,92% Tannic Acid
50% Hydroxycitric Acid
50%,85%,90% Geniposide,10:l,20:l
0.5%,l%,2%Allicin,10:l,20:l
10:1,20:1
5% Gingerols
24% Flavonol Glycosides/6% Terpenelactones
25%,30%,35%,80% Ginsenosides
10:1,20:1
90% Glucomannan
15%,30%Polysaccharides,10:l,20:l
5% Flavonoids
5%, 10% Alkaloids
10%,20%,80% Triterpenoids, TECA 95%
95% Proanthocyanidins,95% Polyphenols
20%,25%,30% Polyphenols
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
16
EXTR
AC
TSPLANT SOURCE BOTANICAL NAME SPECIFICATION
Grassleaf Sweelflag
Green Tea
Gromwell Root
Gymnemic Acids
Gyn ostein ma
Hawthorn Berry
Hawthorn Leaf
Heartsease
Herba Aqastachis
Herba Geran
Herba Leonuri
Herba Loophatheri
Herba Taxilli
Herba violae
Hesperidin
Hibiscus Flower
Honey Goat Weed
Honey Suckle Flower
Hops
Horehound
Horse Chestnut
Horsetail
Huperzine A
Hydrangeu Root
India Madder Root
Inulin
Irvingia Gabonensis Seed
Jujube
Kelp
Kidney Bean
Kiwifruit
Kudzu
Larqeleaf Gentian Root
Lemon Balm
Ligustrum
Lingonberry(Cowberry)
Loquat Leaf
Lotus Leaf
L-Theanine
Luffa sponge
Acorus tatarlnowiiSchott
Camellia Sinensis
Amebic euchroma
Gymnema syivestre 1
Gynostemma pentaphyllum
Crataegus pinnatlfida Bge.
Crataegus pinnatlfida Bge.
Viola trtcoto r L Inn.
Agastache rugosus
Geranium wilfordli Maxim.
Leonurusjaponicus Houtt.
Lophatherumgraclle Bongn.
Taxittus chinensts (DC.)
Violayedoensis Makino
Citrus Sinests
Hibiscus rosa sinensis
Epimedium Grandiftorum
L onicera Japonica
Hamulus iupuius
Lagopsis supina
Aescutus Hippocastanum
Equisetum Arvense
Huperzia Serrata
Hydrangea strigosa Rehd.
Rubia cordifolia L.
Gchorium intybus L
Irvingia gabonensis
Ziziphus Jujuba
Zostera Marina L.
Phaseolus Vulgaris
Fructus Actinidiae chinensis
Pueraria Lobata
Gentiana macrophytta Pall.
Melissa Officinalis
ligustrum tucidum Ait.
Vaccinlumvltis-idaea
Eriobotryajdponica
Nelumbo nucifera Gaertn.
Camellia Sinensis
Luffa cylindrica (L.J Roem.
10:1,20:1
20%-99% Polyphenol5,10-99% EGCG
30%,50%,98% Shikonin,10:l
25%,75% Gymnemic Acids
20%,80%,98% Gypenosides
10:1,15-30% Polysaccharides
2% Hyperosides, 1.8% Vitexin-2"-0-rhamnoside
10:1,20:1
10:1,20:1
10:1,20:1
10:1,20:1
5:1,10:1
10:1,20:1
15:1,30:1
98% Hesperidin
1%,2%,5% Anthocyanidins,10:l,20:l
5-98% Icarin
5-98% Chlorogenic Acid
10:l,20:l,3%Xanthohumol
10:1,20:1
20-90% Escin
2%,7% Silica acid, 10:1,20:1
1%,5%,98% Huperzine A
10:1,20:1
10:1,20:1
90% Inulin
10:1,20:1,5% Flavones
2% Jujuboside
5% Fucoxanthin
1-2% Phaseolin
10:1,20:1
40% Isoflavones,30%,98% Puerarin
10:1,20:1
2.5-10% Rosemarinic Acid, 10:1
10-98% Oleanolic Acid 10-35% Oligomeric,Proanthocyanidines(OPC),
5-25% Anthocyanins 10:1,20:1,10-98% Oleanolic Acid,
25%,90%,98%Ursolic Acid
10:l,20:l,5%-20%Flavones,l-50%Nuciferine
98% L-Theanine
10:1,20:1
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
15917
EXTR
AC
TSPLANT SOURCE BOTANICAL NAME SPECIFICATION
Luo Han Guo
Lycopene
Maca
Magnolia Bark
Maitake mushroom
Malabar spinach
Marigold
Marsh Mallow
Milk Thistle
Mistletoe
Morindda Root
Mangosteen
Mucuna
Mulberry
Maringin
Needle Mushroom
Nettle
Notoqinsenq
Nutmeg
Octocosanol
Olive Leaf
Padiaxel
Passion Flower
Papain
Peppermint
Perilla Leaf
Perilla Seed
Phytosterols
Pine Bark
Plantain
Plantain Seed
Polyqala
Pomegranate Rind
Pomegranate Seed
Propolis
Pu ErTea
Pumpkin Seed
Purple Corn
Purple Sweet Potato
Quercetin
Momordica Grosvenori Swingle
Lycopersicon Esculentum
L epidium meyenii
Magnoliae Officinalis
Grifola frondo sus
Gynura cusimbua (D. Don) S. Moore
Tagetes erecta
Althaea officinalis L
Silybum Marianum
Scurrutap arasiticus
Morinda officinalis How
Garcinia Mangostana.L
Mucuna Pruriens
Moms alba L
Citrus Parodist
Elammultna velutipes
Urtica Dioeca
Panax notoginseng
Myristica fragrans Houtt.
Rice wax
Canarium album Raeusch.
Taxus chinensis
Passiflora Incarnota
Chaenomeles sinensis Koehne
Mentha hapio calyx
Perillafrutescens(L)Britt.
Perillafrutescens(L.)Britt.
Glycine max
Pinus Species
Plantago asiatica L
Plantago asiatica L
Polygala tenuifolia Wiltd.
Punica granatum L.
Punic agran alum L.
Propolis
Camellia sinensis O. Ktze.
Cucurbita Species
ZeaMayzl
Ipomoea batatas L
Sophora flavescens Ait.
5-99% Mogrosides/5-50% Mogroside V
5-20% Lycopene
0.5%,0.6% Macamides+Macaenes
10-98% Honokiol/Magnolol
10-40% Polysaccharides
10:1,20:1
5-90% Lutin,l-10% Zeaxanthin
10:1,20:1
80% Silymarin
10:1
40% Polysacchandes,10:l
10%,30%,90% a-Mangostin, 40%Polyphenols
15%,98%,99% L-Dopa
0.5-2% 1-DNJ
99% Naringin
10-40% Polysaccharides
1%, 2% Silicic Acid, 0.8% Total Sterols
10:1,20:1,5-98% Notoginsenosides
10:1,20:1
10-90% Octacosanol
16%, 18%,20%,30%,40% 01 europein
90-99% Pacliaxel
10:1,20:1,3.5%,4%,5% Total Flavones
1500TU/mg
10:1,20:1
10:1,20:1
10:1,20:1
95% Phytosterols
95% Proanthocyanidins
10:1,20:1
10:1,20:1
10:1,20:1
40% Ellagic Acid, 10:1,20:1
10:1,20:1
50%-98% Propolis
30% Polyphenols
15%, 25% Phytosterols,10:l,20:l
1-25% Anthocyanidins
10-25% Anthocyanidins
98% Quercetin
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
18
EXTR
AC
TSPLANT SOURCE BOTANICAL NAME SPECIFICATION
Radix Adenophorae
Raspberry
Red Beet Root
Red Clover
Reishi Mushroom
Resveratrol
Rhizoma Anemarrhenae
Rhizoma Corydalis
Rhizoma Drynariae
Rhizoma Kaempferiae
Rhodiola Rosea
Rosemary
Royal jelly powder
Rutin
Saw Palmetto Berry
Schisandra
Scutellaria
Sea Buckthorn
Senna
Sesamin
Shikonin
Shitake mushroom
Siberian Ginseng
Soy Bean
St. John's Wort
Stevia
Straw Mushrrom
Sweetberry Honeysuckle
Sweet Wormwood Herb
Thunberg Fritillary
Tribulus
Uva Ursi
Valerian
Vietnamese Sophora Root
White Mulberry Root-bark
White Willow Bark
Wild Yam
Yerba Mate
Yohimbe
Adenophora stricta Miq ,
Fructus Rubi
Betavutgarisvar rubra
Trifolium Pratense
Ganderma Lucidum
Polygonum Cuspldatum
Anemarrhena asphodeioides Bge.
Co/ydalis yanhusuo W. T. Wang
Drynaria fortunei (Kunze )
Kaempferia gatanga L.
Rhodiola Rosea
Rosmarinus Officinalis
Royaljetly
Ruta graveolens L.
Serenoa Repens
Schizandra Chinensis
Scutellaria baicalensls George
Fructus Hippophae
Cassia Senna
Sesamum indicum
Arnebia euchroma
Lent inula edoder
Acanthopanax senticosus
Glycine max
Hypericum Perforatum
Ste via Rebaudiana
Volvarlella volvacea Sing.
Lonlcera caerulea L
Artemisia annua I.
Frititlaria thunbergii Miq.
Tribulus Terrestris
Arcotostaphylos Esculentu
Valeriana Officinalis
Sophora subprostrata Chun
Taxillus chinensis (DC.)
SalixAba
Dioscorea Vlttosa
Hex paraguarensis
Pausinystiiia Yohimbe
10:1,20:1
10:1,20:1
10% Betanin
2.5-60% Total Isoflavones
10-40% Polysaccharides
20%-99% Resveratrol
10:1,20:1
10:1,20:1
10:1,20:1
10:1,20:1
1-5% Rosavin,l-10% Salisorosides
5-50% Rosemarinic Acid
5%, 6% 10-HDA
95% Rutin
25% Fatty Acids/Phytosterols, 45% Fatty Acids
1-13% Schisandrins
30%,80%,95% Baicalin
10%-50% Flavones
10%,20% Sennosides
10-98% Sesamin
10-98% Shikonin
10%-40% Polysaccharides
0.8%,1% Electherosides
10-90% Isoflavones,90% Saponin,99%Lecithin
0.3%,0.5% Hypericin
40-99% Steviosides,20-98%RA
10%-40% Polysaccharides
1-36% Anthocyanidins
98%,99% Arteannuin
10:1,20:1
20%-90% Saponins
10%,20% Arbutin,20%-98%Ursolic Acid
0.4%,0.8% Valerianc Acids
10:1,20:1
10:1,20:1
2.5%,10%,15%, 30%,98% Total Salicin
8%,16% Saponins
15% Polyphenols,10:l,20:l
2%,8% Yohimbines, 98% Yohimbine HCL
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
19
PROBIOTICS
There are about 400 types of intestinal microorganisms. There are more than
100 trillion intestinal microorganisms (cf: the number of cells in human body
is 60 trillion). They weigh about 1 kg per adult and form a characteristic flora in
the body depending on the person's age. However, our digestive system is in
jeopardy when the microorganism flora is disrupted due to the Western-style
diet containing high fat and high protein contents, excess stress, irregular life
style, lack of exercise and antibiotics.
21
Bestpharma is the exclusive partnerof BIFIDO Co., Ltd,a company dedicatedto research on human intestinal health.
BIFIDO CO., LTD.
BIFIDO Co., Ltd. Has been focusing on Bifidobacterium strains and for 20 years
in order to fully utilize science in nutritious and functional food materials for the
improvement of human health and well-being. They focus on basic research and
product development using probiotics. Among various probiotics,
Bifidobacterium is considered to be the most beneficial microorganism for the
maintenance of microbial balance in the intestinal tract.
Nowadays, Bifidobacterium and other lactic bacteria are being applied widely in
functional foods. BIFIDO is in the leading edge in the development of
human-health promoting Bifidobacterium.
22
R & D System
The BIFIDO Central Research Institute was
established for the purpose of finding
health-oriented new materials and promoting
health of human beings. The research results
of BIFIDO Co., Ltd. are applied to independent
business items ranged from high functional
food materials to new medicine development
that used the gene expression system,
through establishing efficient human
networks including the lab of the Food Science
and Nutrient Department at Seoul National
University, and exchanging openly with
exterior research teams.
As a proud exclusive partner, Bestpharma offers the following bacterial strains in bulk or in mixes,
as well as finished products with BIFIDO in-house formulations.
Main current R&D Projects are:
Development of allergy-suppressive Bifidobacterium
and Lactobacillus.
Development of rotavirus-inhibiting Bifidobacterium;
BORI protein, a novel rotavirus-inhibiting active
component, is in pending for patent in USA, Europe,
and Japan.
Development of tumor-suppressive Bifidobacterium;
chiro-inositol containing polysaccharide, a novel
tumor-suppressive active component, was
characterized.
Development of food-grade vectors for
Bifidobacterium.
23
HUMAN STUDIES
Irritable Bowel SyndromeEffect of Probiotics on Symptoms in Korean Adults with Irritable Bowel SyndromeGut and Liver, Vol.3, No.2. June 2009, pp. 101-107
Background/Aims:
Irritable bowel syndrome (IBS) is a troublesome disease. Some strains of
probiotics reportedly exert remarkable immunomodulatory effects, and so
we designed a prospective double-blind randomized placebo-controlled
clinical study to assess their effects in Korean adults with IBS.
Methods:
IBS patients who met Rome III criteria were randomly assigned to receive
composite probiotics or placebo. A total of 20 billion lyophilized bacteria
were administered twice daily for 8 weeks. Primary outcome variables were
symptom scores consisting of abdominal pain, flatulence, defecation
discomfort, and sum of symptom scores. A visual analogue scale was used
to quantify the severity. Secondary outcome variables consisted of the
quality of life and bowel habits including defecation frequency and stool
form.
Results:
Thirty-six and 34 patients were randomized to the probiotics and placebo
groups, respectively. Intention to-treat analysis showed significant
reductions in pain after 8 weeks of treatment: −31.9 and −17.7 in the
probiotics and placebo groups, respectively (p=0.045). The reductions in
abdominal pain, defecation discomfort, and sum of scores were more
significant in 58 patients with a score of at least 3 on the baseline
stool-form scale. Conclusions: Composite probiotics containing
Bifdobacterium bifdum BGN4, Lactobacillus acidophilus AD031, and other
species are safe and effective, especially in patients who excrete normal or
loose stools.
24
Atopic DermatitisProbiotics in Primary Prevention of Atopic Dermatitis.Forum Nutr. Basel, Karger, 2009, vol 61, pp 117–128
Effect of probiotic mix (Bifidobacterium bifdum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial.
Controversy exists regarding the preventive effect of probiotics on the
development of eczema or atopic dermatitis. We investigated whether
supplementation of probiotics prevents the development of eczema in
infants at high risk. In a randomized, double-blind, placebo-controlled trial,
112 pregnant women with a family history of allergic diseases received a
once-daily supplement, either a mixture of Bifidobacterium bifidum BGN4,
B. lactis AD011, and Lactobacillus acidophilus AD031, or placebo, starting
at 4–8 wks before delivery and continuing until 6 months after delivery.
Infants were exclusively breast-fed during the first 3 months, and were
subsequently fed with breast milk or cow’s milk formula from 4 to 6 months
of age. Clinical symptoms of the infants were monitored until 1 yr of age,
when the total and specific IgE against common food allergens were
measured. A total of 68 infants completed the study. The prevalence of
eczema at 1 yr in the probiotic group was significantly lower than in the
placebo group (18.2% vs. 40.0%, p = 0.048). The cumulative incidence of
eczema during the first 12 months was reduced significantly in probiotic
group (36.4% vs. 62.9%, p = 0.029); however, there was no difference in
serum total IgE level or the sensitization against food allergens between the
two groups. Prenatal and postnatal supplementation with a mixture of B.
bifidum BGN4, B. lactis AD011, and L. acidophilus AD031 is an effective
approach in preventing the development of eczema in infants at high risk of
allergy during the first year of life.
HUMAN STUDIES
25
HUMAN STUDIES
Rotavirus infections
Sowha Children’s Hospital
We aimed to study the effect of lactic acid bacteria administration on patients with rotavirus gastroenteritis.
From December 2002 to September 2003, 57 patients with gastroenteritis(rotavirus passitive) under treatment in Sowha Children’s Hospital were divided into lactic acid bacteria administration group(28) and control group(29).
-Lactobacillus acidophilus, Bifidobacterium longum BORI and prebiotics (galacto-oligosaccharide etc.) were used. -Three days administration, 2 times per day, 2g for 1 time (contains L.acidophilus 2.0 X 108 CFU/g, B.longum BORI 2.0 X 109 CFU/g ).
Total days of emesis, times of emesis, times of diarrhea, total days of diarrhea; statistics analysis.
After administration of lactic acid bacteria, the decreased times of diarrhea
shows that lactic acid bacteria is beneficial for rotavirus gastroenteritis.
If more clinical research can be achieved in the future, the substitution
effect of lactic acid bacteria can be used to decrease the unnecessary
treatment of antidiarrheic and antibiotic for virus gastroenteritis.
Lactic acid bacteria ( – )
Lactic acid bacteria ( + )
Total days of diarrhea (day)
Total days of fever (day)
Times of diarrhea (time/day)
Total days of emesis (day)
26
PAPERCharacterization of a Bifidobacterium bifidum BORI
dipeptidase belonging to the U32 family.
Appl environ Microbiol. 2007 Sep; 73(17):5598-606
A dipeptidase was purified from a cell extract of
Bifidobacterium longum BORI by ammonium sulfate
precipitation and chromatography on DEAE-cellulose
and Q-Sepharose columns. The purified dipeptidase
had a molecular mass of about 49 kDa and was
optimally active at pH 8.0 and 50 degrees C. The
enzyme was a strict dipeptidase, being capable of
hydrolyzing a range of dipeptides but not tri- and
tetrapeptides, p-nitroanilide derivatives of amino
acids, or N- or C-terminus-blocked dipeptides.
A search of the amino acid sequence of an internal
tryptic fragment against protein sequences deduced
from the total genome sequence of B. longum
NCC2705 revealed that it was identical to an internal
sequence of the dipeptidase gene (pepD), which
comprised 1,602 nucleotides encoding 533 amino
acids with a molecular mass of 60 kDa, and thereby
differed considerably from the 49-kDa mass of the
purified dipeptidase. To understand this discrepancy,
pepD was cloned into an Escherichia coli expression
vector (pBAD-TOPO derivative) to generate the
recombinant plasmids pBAD-pepD and
pBAD-pepD-His (note that His in the plasmid
designation stands for a polyhistidine coding region).
Both plasmids were successfully expressed in E. coli,
and the recombinant protein PepD-His was purified
using nickel-chelating affinity chromatography and
reconfirmed by internal amino acid sequencing. The
PepD sequence was highly homologous to those of
the U34 family of peptidases, suggesting that the B.
longum BORI dipeptidase is a type of cysteine-type
N-terminal nucleophile hydrolase and has a
beta-hairpin
PATENTBifidobacterium bifidum BORI(AR81) enabling
inhibition of rotavirus and active protein separated
therefrom.
This invention is regarding the new bacterium that
inhibits rotavirus, which is known as a main source
that causes diarrhea and enteritis in young animals
such as an infant, cow, horse, pig and monkey, etc.,
and regarding the antirotavirus active protein that is
generated by this new Bifidobacterium longum
BORI(AR81).
27
MARINE
Omega 3 is a member of the Essential Fatty Acids family (EFA). Unsaturated
fatty acids can be divided into two categories, omega-6 EFA and omega-3 EFA,
including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
This last group of acids has a large influence on the human body (cardio-
vascular system, brain function, metabolic processes). DHA has a very
important role during human gestation and lactation.
In theory, a person should be able to synthesize omega-3 EPA and DHA from
dietary omega-3 ALA (alpha-linolenic acid – located in dark green vegetables).
In practice, this process is inefficient. Researchers concluded that omega-3 EPA
and DHA should be taken with food supplements. High quality of the fish oil
(mainly obtained from liver, flesh) is one of the sources of EPA and DHA omega-3
fatty acids. The oil can be mainly obtained from fish found in the cold waters of
the sea, such as tuna, salmon, anchovies, but also cod, shark, sardine.
Bestpharma offers the purest forms of Omega 3 oils supplied directly from the
manufacturers. Each manufacturer is carefully selected with regards to fishing
methods (from catch to processing), processing methods and lowest possible
oxidation levels. This enables us to supply the most fresh and highest quality
oil to our customers.
29
PUREFISH OILS:
COD LIVER OILAn oil obtained from livers of cods.This oil has a high level of omega-3 fatty acids. Cod liver oil
also contains vitamin A and vitamin D. It prevents:
decreases in immunity,
cardiac disorders,
maintains the correct level of cholesterol in states of impaired lipid metabolism.
SHARK LIVER OILIt has been used for centuries as a folk remedy to promote the healing of wounds and as a remedy for respiratory tract and digestive system problems.Shark liver oil is a rich source of alkylglycerols, chemicals
that may have anti-cancer properties. Other chemicals in
shark liver oil being studied against cancer are squalamine
and squalene.
Alkylglycerols are thought to be helpful in several ways. It
has been suggested that they fight cancer by killing tumor
cells indirectly. Proponents also claim that alkylglycerols
reduce the side effects of chemotherapy and radiation
treatment. Because of their supposed immune-boosting
effects, alkylglycerols are also claimed to help against
colds, flu, chronic infections, asthma, psoriasis, arthritis,
and AIDS.
Other compounds in shark liver oil, such as squalamine
and squalene, have also been promoted to have
anti-cancer effects. It is also being studied for use against
macular degeneration, an eye condition that results in loss
of vision. Squalene has been promoted as having
cell-protecting abilities, which may reduce the side effects
of chemotherapy.
30
SALMON OILA 100% natural oil, manufactured from salmons bred in the pure waters of southern Chile.Its production process allows it to certify
a controlled concentration of essential long-chain
Omega-3 fatty acids, Eicosapentaenoic acid (EPA)
and Docosahexaenoic acid (DHA).
18/12 F ISH OIL18/12 is a 100% natural edible oil, originating in the sea, highly refined and deodorized, enriched with long-chain Omega-3 fatty acids.Eicosapentaenoic acid (EPA) and Docosahexaenoic
acid (DHA), are essential for the proper nutrition of
human beings. The formulation of 18/12 oil allows
its application for direct consumption in the form
of liquid preparations or syrups, in gelatin
capsules, or in the formulation of functional foods.
Among its multiple benefits, it can be highlighted
that the consumption of 18/12 oil contributes to
maintaining and protecting the cardiovascular
system, reducing cholesterol and triglycerides in
the blood.
EPA
DHA
Total Omega-3
≥ 4.0
≥ 4.0
≥ 9.0
≥ 35
≥ 35
≥ 80
ITEM CONTENT[%]
CONTENT[mg/g]
31
OMEGA 3POWDERS
Omega-3 powders are manufactured using a breakthrough proprietary (U.S. patent pending) technology. Not only does this technology produce higher Omega-3 contents, it also gives oxidation stability. Omega-3 powder does not need to be refrigerated and is made from 100% fish oil or 100% plant oil.
Breakthrough TechnologyIt should be noted that advanced technology
increases the purity and oxidation stability of the
products. The health benefits and market demand
have been the driving force to research, develop
and manufacture Omega-3 powder and overcome
the obstacles over easier use, freshness,
purification and taste to provide the nutrition
industry with optimal applications.
Why Bestpharma Omega-3 Powder?
Patented form to create nature GRAS Omega-3 powder
Non-microencapsulated powder – double on DHA and EPA contents
High purity and concentrations of Omega-3 from 100% fish oil or 100% plant oil
Carbohydrate and protein free
High bio-availability
No refrigeration needed with longer shelf life
Almost tasteless and odorless
Easy to use for smaller capsules, tablets or food applications
Manufacture customized Omega-3 powder to meet specific formulations
L IST OF PRODUCTS
Omega-3 F30 PowderFish origin, Omega-3 30% (EPA + DHA)
Omega-3 P50 PowderPlant origin, Omega-3 50% (EPA + DHA + ALA)
Omega-3 PF40 PowderFish and plant origin, Omega-3 40%
Omega-3 A35 PowderAlgae origin, DHA ≥35%
32
OMEGA-3HCONCENTRATED FISH OILS:
Concentrated fish oil is a natural source of omega-3. It contains two times more omega-3 than other products containing fish oil.
Concentrated fish oil is the most common form
of food supplements. The types of fish that are
usually used for the production: sardines,
anchovies, herring, mackerel, salmon and
tuna.
Bestpharma is dedicated to supplying high
quality concentrated fish oils. During
production of Omega-3H oils, in addition to
traditional technologies in edible oil
industries, extra process and proprietary
purification technologies are adopted. This
enables our concentrates to set the most
stringent quality standards, which meet or
exceed all known limits set by GOED Voluntary
Monograph, Ph Eur Monograph and other
institutes.
GRADE UNIT EP USP GOED OMEGA-3H
Arsenic (As)
Lead (Pb)
Mercury (Hg)
Cadmium (Cd)
DDT (sum: p,p’-DDE + o,p’-DDT + p,p’-DDT + o,p’-DDD + p,p’-DDD)
HCB
Lindane
PCBs
Dioxins like PCBs
PCDD+PCDF (Dioxins+Furans)
Dioxins+Furans+Dioxins like PCBs
mg/kg
mg/kg
mg/kg
mg/kg
mg/kg
mg/kg
mg/kg
mg/kg
pg/kg
pg/kg
pg/kg
< 0.1
< 0.1
< 0.1
< 0.1
< 2
10
< 0.1
< 0.1
< 0.1
< 0.1
0.05
0.05
0.5
1
< 0.1
< 0.1
< 0.1
< 0.1
< 0.09
< 3
< 2
NA
< 0.1
< 0.05
< 0.005
< 0.01
< 0.01
< 0.005
< 0.005
< 0.01
< 3
< 1
< 4
Omega-3H ogranic pollutants content comparison to EP, USP and GOED standards
33
Omega-3H oils are guaranteed to have the lowest possible oxidation levels. This was achieved by
focusing on protecting the oil from exposure to air and unnecesary heating with high temperatures during
the whole process. This was carried out thanks to an improved Short-Path Distillation (SPD) technology
which allows to conduct the distillation process in airtight, vacuum conditions in nitrogen environment.
This state-of-the-art process lowers the evaporation temperatures of processed oil. The measures taken
in the production of Omega-3H concentrates give the purest Omega 3 oil concentrates twith the lowest
possible oxidation levels.
GRADE UNIT EP USP GOED OMEGA-3H
Acid value
Peroxide value
Anisidine value
TOTOX
mgKo/g
meg/kg
< 2.0
< 10
< 20
NA
< 2.0
< 10
< 15
NA
< 3.0
< 5
< 20
< 26
< 1.0 (0.5, ultra)
< 3 (2. ultra)
< 15 (5, ultra)
< 20 (9, ultra)
Omega-3H oxidation levels comparison to EP, USP and GOED standards
34
TRIG
LYC
ERID
E FO
RM
CODE NAME EPA [mg/g] DHA [mg/g]
035024
035025
035030
035031
035032
035033
035017
035018
035019
035020
035021
035022
035023
035000
035035
035036
035037
035038
035039
035034
035026
035027
035028
035029
035010
035011
035012
035013
035014
035015
035016
035008
035009
035001
035002
035003
035004
035005
035006
035007
035008
Omega-3H 3322TG
Omega-3H 3020TG
Omega-3H 2050TG
Omega-3H 1050TG
Omega-3H 2040TG
Omega-3H 1040TG
Omega-3H 6015TG
Omega-3H 5525TG
Omega-3H 5025TG
Omega-3H 5020TG
Omega-3H 4030TG
Omega-3H 4020TG
Omega-3H 3624TG
Omega-3H 6020TG
Omega-3H EPA700TG Ultra
Omega-3H DHA700TG Ultra
Omega-3H 7505TG Ultra
Omega-3H 7010TG Ultra
Omega-3H 0575TG Ultra
Omega-3H 1070TG Ultra
Omega-3H 2050EE
Omega-3H 1050EE
Omega-3H 2040EE
Omega-3H 1040EE
Omega-3H 5525EE
Omega-3H 5025EE
Omega-3H 5020EE
Omega-3H 4030EE
Omega-3H 4020EE
Omega-3H 3624EE
Omega-3H 3322EE
Omega-3H 1070EE
Omega-3H 6015EE
Omega-3H 1812EE
Omega-3H 3020EE
Omega-3H EPA700EE Ultra
Omega-3H DHA700EE Ultra
Omega-3H 7505EE Ultra
Omega-3H 7010EE Ultra
Omega-3H 0575EE Ultra
Omega-3H 1070EE Ultra
330
300
200
100
200
100
600
550
500
500
400
400
360
600
700
0
750
700
50
100
200
100
200
100
550
500
500
400
400
360
330
100
600
180
300
700
0
750
700
50
100
220
200
500
500
400
400
150
250
250
200
300
200
240
200
0
700
50
100
750
700
500
500
400
400
250
250
200
300
200
240
220
700
150
120
200
0
700
50
100
750
700
ETH
YL E
STH
ER F
OR
M1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
4135
BESTCOAT
Bestpharma offers a broad range of tablet coating systems, many of which can
be designed according to the Customer's needs.
We offer three systems of BestCoat™ mixtures ready for preparation of coating
suspensions. They are available in a wide range of colors based on the Pantone
color palette.
We also provide free samples in order to verify the color. We start a
batch production only after approval of the presented sample by the
Customer.
Our advantage is our flexible approach to the Customer. We cooperate
with companies which can set-up the coating process on every coating
machine and train the staff in a particular process.
We encourage you to look through the details of our offer.
* For pharmaceutical products, it is necessary to inform BESTPHARMA about such intended use.
The coatings are based on both syntheticand natural pigments
Each coating system is tailored to the Customer's needs.
The color of coating is tailored to the Customer's needs.(In the case of natural pigments, the number of available colors is limited)
Available for both the food, and pharmaceutical industry*.
01
02
03
04Best
Coat
™sy
stem
37
First, the BESTCOAT™ coating is applied to the tablets, with a chosen color, in order to obtain a depth effect.
The process of basic coating application is usually continued until the increase in tablets mass amounts to 3 % of non-coated tablets.
S IMPLICITY
Application of double-system coatings produces a magnificent visual effect and, at the same time, does not significantly increase
the amount of work or production costs.
The recommendations regarding proper use of the BESTCOAT™ PEARL coating process are similar, as in the case of the basic
system. The recommended concentration of BESTCOAT™ PEARL solution expressed as dry content is from 12% to 20%.
Coating application is very simple
Basic coating system, in which all the ingredients are passed as fit for the food industry. Available in various colors, based on soluble pigments or color lakes.
Hypromellose (HPMC)
Polydextrose
Titanium dioxide
Polyethylene glycol
Talc
E 464
E 1200
E 171
E 1521
E 553b
BESTCOAT ™
If polyethylene glycol is not acceptable in the composition, we suggest this coating in which PEG was substituted with medium -chain triglycerides (MCT).
BESTCOAT ™
MCT
Hypromellose (HPMC)
Polydextrose
Titanium dioxide
Polyethylene glycol
Talc
Medium chain triglycerides
E 464
E 1200
E 171
E 1521
E 553b
—
A system with additional plasticizer - triacetin, which increases the coating's plasticity and its adhesion to the core.
BESTCOAT ™
TRI
Hypromellose (HPMC)
Titanium dioxide
Lactose monohydrate
Polyethylene glycol
Triacetin
E 464
E 171
—
E 1521
E 1518
01
Tablets are then dried up for 10 minutes.
02
Next, application of the BESTCOAT™ PEARL coating proceeds. The process of spraying is continued until the increase in mass reaches from 0.5 % to 1.5 % of non-coated tablet cores.
Both systems are compatible, and it is not necessary to wash hoses and nozzles before application of the BESTCOAT™ PEARL system.
03
38
Hypromellose (HPMC)
Potassium Aluminum Silicate
Titanium dioxide
Polyethylene glycol
E 464
E 555
E 171
E 1521
A system which gives the tablets a pearlescent shine. A double-system solution comprising of the BESTCOAT™ basic system and the BESTCOAT™ PEARL system.
The procedure of coating preparation is similar. The coating system comprises of a dry mixture of ingredients which are ready for direct preparation of the coating suspension. The system does not require a homogenizer. A container with a low speed mixer is enough.
BESTCOAT™PEARL -
Hypromellose (HPMC)
Polydextrose or Sucrose
Titanium dioxide
Sorbitol
Talc
Medium chain triglycerides or Triacetin
E 464
E 1200
E 171
E 420
E 553b
E 1518
BESTCOAT FLEXIBLE MEMBRANE™ is an innovation on the coating systems market and it performs very well in dealing with the so called „difficult cores”.
The latest product by Bestpharma. Owing to the applied composition of ingredients, the system ensures that the obtained coating is elastic. It is important in the case of tablets – cores, which tend to expand. The version of the system with sucrose is the cheapest coating in our offer. It is available both in white color, and in any other color offered by Bestpharma. It is perfectly suitable as a substitute of former coatings used in sucrose coated tablets and, at the same time, it allows coating mass increase by 3%. The coating has a sweet taste and so it imitates former sucrose coated tablets. In case you want to increase sweetness, we also offer a version in which a combination of sucrose and a sweetener – sucralose is used. In applications in which the content of sugar is undesirable, we apply polydextrose . Depending on our customers’ needs the system can utilize two variants of plasticizers. We can prepare an elastic coating using triacetin or medium-chain triglycerides as plasticizers.
BESTCOATFLEXIBLE MEMBRANE™
39
RECOMMENDATIONS DESCRIPTION
Container, tank for solution preparation
Mixer: size and speed
Recommended concentrations of the suspension expressed as dry content
Water temperature
The procedure of dissolving (suspending) the dry coating mixture
Filtering of ready solution
The container size should be adjusted to the amount of solution. The volume taken up by the solution in the tank should be from 60% to 75% of the whole tank. The tank should be slender, i.e. higher than broader. It should be remembered that an another container is required for pouring the solution through a sieve before coating.
The type of mixer is very important, since using improper mixer can produce foam in the suspension, which is undesirable. The best way is to use a paddle mixer. The mixer should be immersed in the solution 3 - 5 cm from the bottom of the container or tank. Mixer speed should be adjusted, so as to form a swirl. The mixer diame-ter should be in the range of 1/4-1/3 of the container diameter.
The solution concentration should be adjusted to the process and to the owned equipment. The recommended solution concentra-tion expressed as dry content is from 12% to 20%.
To prepare the coating suspension, you should use purified water with the room temperature of 30°C.
The dry coating mixture should be poured into the water container directly into the swirl, with constant mixing. Too rapid pouring should be avoided, so as not to produce big agglomerates of the mixture. Also, you should not let the mixture float on the surface. After adding the calculated amount of the mixture, you should decrease the mixer speed and continue mixing for 45 minutes.
Ready solution should be poured through a sieve with 0.4-mm holes in order to get rid of lumps, which prevents nozzles from blocking, and assures smooth surface of tablets. The filtered solution should be constantly mixed at low speed, during the whole coating process.
COATING PREPARATION
SUSPENSION PREPARATION
40
RECOMMENDATIONS DESCRIPTION
Preparation of tablet cores for the process
Coating process parameters
Mass increase
Termination of coating process
Tablets stabilizing
Bed temperature should be adjusted to the composition of tablet cores. If there are no restrictions associated with the stability of cores, it is recommended to warm up the bed up to 35°C. The warming up of the bed should be conducted with the drum rotation being turned on from time to time.
The spraying air pressure depends on the nozzles applied and should be 2.2 bar - 3.2 bar. Before starting the process you should check the correctness of spraying, and particularly the shape of the sprayed suspension. It is best to do it outside the drum, by spraying the coating on a chosen flat surface, e.g. a steel tray. After starting the process it is necessary to apply vacuum in the drum, which protects from excessive dusting. The temperature of inlet air pressure and its flow rate should be adjusted to the owned equip-ment, the size of bed, number of nozzles, and the rotation rate of the drum. The recommended inlet air temperature should be 45-55°C. It is recommended to apply slower rotation rate of the drum and slower spraying at the beginning of the process, in order to strengthen the cores. Next process can be sped up to ensure its efficiency, while maintaining its quality parameters.
The increase of coating mass should be adjusted to the require-ments of the process, the quality of cores, and marketing demands. Most of the times, it is recommended to continue the process until a 3% to 4% increase of tablet mass is reached.
Before unloading, the bed should be dried up at 20 - 25°C, at the minimum rotational speed of the drum. The process should be continued for 20 minutes.
After the coating process is complete and the coated tablets are unloaded, they should be left for approximately 2 hours in open container to reach equilibrium with the environment.
COATING PROCESS
41
Y 001 Y 006 Y 011 R 001
Y 001 Y 007 Y 012 R 002
Y 002 Y 008 Y 013 R 003
Y 003 Y 009 Y 014 R 004
Y 004 Y 010 R 005
BESTCOAT COLORS
YELLOW (Y) RED (R)
Below you will find the most popular colors, often chosen by our customers. As mentioned before, we are able to prepare any color based on the Pantone® color pallete.
* Please note that the color propositions and symbols do not correspond to a specific BestCoat mixture. The symbols only indicate the chosen color
42
43
R 006 001 G 001B 005
R 007 B 002 B 006 G 002
R 008 B 003 B 007 G 003
R 009 B 004 B 008 G 004
B 009 G 005
BLUE (B)
CONTACT DETAILS
+48 22 247 28 96
www.bestpharma.pl
03-475 Warsaw
2 Borowskiego street (floor 5)
44
EXW
FCA
FAS
FOB
CFR
CIF
(2)
CPT
(1)
CIP
(1) (
2)D
ATD
APD
DP
Ex W
orks
Free
Car
rier
Free
Al
ongs
ide
Ship
Free
O
nboa
rd
Vess
el
Cost
&
Frei
ght
Cost
, In
sura
nce
&
Frei
ght
Carr
iage
Pai
d To
Carr
iage
And
In
sura
nce
Paid
To
Deliv
ered
At
Term
inal
Deliv
ered
At
Plac
eDe
liver
ed
Duty
Pai
d
SERV
ICES
Who
Pay
sW
ho P
ays
Who
Pay
sW
ho P
ays
Who
Pay
sW
ho P
ays
Who
Pay
sW
ho P
ays
Who
Pay
sW
ho P
ays
Who
Pay
s
Orig
in W
areh
ouse
Pa
ckag
ing
Serv
ice
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Selle
r
Orig
in L
oadi
ngBu
yer
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Orig
in E
xpor
t Cus
tom
s De
clar
atio
n/Du
ty/T
axBu
yer
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Deliv
ery
to P
ort o
f Ex
port
/Inl
and
Frei
ght
Buye
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Selle
r
Orig
in T
erm
inal
/Por
t Ch
arge
sBu
yer
Buye
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Load
ing
on V
esse
lBu
yer
Buye
rBu
yer
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Carr
iage
Cha
rges
(O
cean
/Air
Frei
ght)
Buye
rBu
yer
Buye
rBu
yer
Selle
rSe
ller
Selle
rSe
ller
Selle
rSe
ller
Selle
r
Insu
ranc
eBu
yer
Buye
rBu
yer
Buye
rBu
yer
Selle
rBu
yer
Selle
rSe
ller
Selle
rSe
ller
Dest
ina t
ion
Term
inal
/Por
t Cha
rges
Buye
rBu
yer
Buye
rBu
yer
Buye
rBu
yer
Selle
rSe
ller
Selle
rSe
ller
Selle
r
Deliv
ery
to P
lace
of
Dest
inat
ion
Buye
rBu
yer
Buye
rBu
yer
Buye
rBu
yer
Buye
rBu
yer
Buye
rSe
ller
Selle
r
Impo
rt C
usto
ms
Clea
ranc
e/Ta
x/Du
tyBu
yer
Buye
rBu
yer
Buye
rBu
yer
Buye
rBu
yer
Buye
rBu
yer
Buye
rSe
ller
(1) R
isk
of lo
ss o
r dam
age
is tr
ansf
erre
d fr
om S
elle
r to
Buye
r whe
n th
e go
ods
have
bee
n de
liver
ed to
the
carr
ier.
(2) W
hile
the
Selle
r is
resp
onsi
ble
for i
nsur
ance
cov
erag
e du
ring
the
mai
n vo
yage
, the
buy
er m
ay h
ave
addi
tiona
l 'in
sura
ble
inte
rest
' and
pru
denc
e m
ay
dict
ate
purc
hase
of a
dditi
onal
cov
erag
e.
45
INTE
RN
ATI
ON
AL
CO
MM
ERC
IAL
TER
MS