DNA Replication in Eukaryotic Cells Monograph 31 Edited by Melvin L. DePamphilis , National Institute of Child Health and Human Development, National Institutes of Health

DNA replication is a central cog in the machinery of cell and viral proliferation. After significant advances in the past few years, its regulation is now understood in un- precedented depth.

This is the first book to provide a detailed and thoroughly up-to-date review of the complexity of DNA replication in eukaryotic cells. It is organized into three parts: Concepts, a distillation of underlying principles; En- zymes, a description of each protein class involved; and Systems, a review of events over a wide range of or- ganisms. The book is therefore invaluable for teachers who want a current survey of a topic central to the biology syl- labus; investigators of replication who will appreciate a re- markably concise, central source of knowledge in their specialty; and scientists s tudying other biological functions on which DNA replication has an impact.

C O N T E N T S CONCEPTS Mechanisms for Replicating DNA (G.S. Brush and T.J. Kelly); Origins of DNA Replication (M.L. DePamphilis); Roles of Transcription Factors in DNA Replication (P.C. van der Vliet); Roles of Nuclear Structure in DNA Replication (R. Laskey and M. Madine); Mechanisms for Priming DNA Synthesis (M. Salas, J.T. Miller, J. Leis, and M.L. DePamphilis); Mechan- isms for Completing DNA Replication (D. Bastia and B.K. Mohanty); Fi- delity of DNA Replication (J.D. Roberts and T.A. Kunkel); DNA Exci- sion Repair Pathways (E.C. Friedberg and R.D. Wood); Chromatin Struc-

ture and DNA Replication: Implications for Transcriptional Activity (A.P. Wolffe); Roles of Phosphorylation in DNA Replication (K. Weisshart and E. Fanning); Control of S Phase (K. Nasmyth); Temporal Order of DNA Replication (I. Simon and H. Cedar); Changes in DNA Replication during Animal Development (J.L. Carminati and T.L. Orr-Weaver); Comparison of DNA Replication in Cells from Prokarya and Eukarya (B. Stillman) ENZYMES Celltdar DNA Polymerases (T.S.-F. Wang); Viral DNA Polymerases (D.M. Coen); DNA Replication Accessory Proteins (U. Hiibscher, G. Maga, and V.N. Podust); DNA Helicases (J.A. Borowiec); DNA Ligases (R. Nash and T. Lindahl); DNA Topoisomerases (A. Hangaard Andersen, C. Bendixen, and O. Westergaard); Telomerases (C.W. Greider, K. Col- lins, and C. Autexier) SYSTEMS SV40 and Polyomavirus DNA Replication (J.A. Hasseil and B.T. Brin- ton); Papillomavirus DNA Replication (A. Stenlund); Adenovirus DNA Replication (R.T. Hay); Herpesvirus DNA Replication (M. Challberg); Epstein-Barr Virus DNA Replication (J.L. Yates); Poxvirus DNA Rep- lication (P. Traktman); Parvovirus DNA Replication (S.F. Cotmore and P. Tattersall); Replication of the Hepatitis Virus Genome (C. Seeger and W.S. Mason); Geminivirus DNA Replication (D.M. Bisaro); Baculovirus

DNA Replication (C.H. Ahrens, D.J. Leisy, and G.F. Rohrmann); DNA Replication in Yeast (C.S. Newlon); DNA Replication in Tetrahymena (G.M. Kapler, D.L. Dobbs, and E.H. Blackburn); DNA Replication in Physarum (G. Pierron and M. B~nard); Dif- ferential DNA Replication in In- sects (S.A. Gerbi and F.D. Ur- nov); DNA Replication in Xeno- pus (J.J. Blow and J.P.J. Chong); DNA Replication in Mammals (N.H. Heintz); DNA Replication in Plants (J. Van't Hot'); Mito- chondrial DNA Replication (D.A. Clayton); Kinetoplast DNA Replication (A.F. Torri, L.J. Rocco Carpenter, and P.T. Englund)

1996, 1058 pp., illus., color plates, index Cloth $125 ISBN 0-87969-459-9

Telomeres Monograph 29 Edited by Elizabeth H. Blackburn, University of California, San Francisco; Carol W. Greider, Cold Spring Harbor Laboratory

--Here's what the reviewers have to say: "...the present book is both timely and much needed. The litera- ture has become increasingly diverse and voluminous, making it difficult for the casual reader or newcomer to the field to gain a balanced perspective. Telomeres provides an excellent, easy-to- read introduction for such readers. Moreover, since the book con- tains a wealth of information on all aspects of telomere biology and biochemistry, it should prove tremendously useful to even the most experienced telomere researcher.

A major strength of the book lies in the breadth of its coverage and the way it links the diverse topics. Each chapter concentrates on a different aspect of telomere research and where necessary describes the experimental system used in performing the re- search. Thus the book covers topics as diverse as telomere addi- tion in ciliates, gene expression and telomere position effect in yeast, construction of mammalian artificial chromosomes, and telomerase and cancer in humans. Yet the various chapters are not isolated units. The authors frequently refer to other chapters and give short accounts of topics that are discussed in detail else- where, providing the reader with a sense of continuity. A further useful and enjoyable feature of the book is its historical perspec- tive, which allows the reader to see how the field developed be- fore being plunged into the intricacies of current knowledge."

---Science 1995, 396 pp., illus., index ISBN 0-87969-457-2 Cloth $80

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VOLUME 10

GENES

DEVELOPMENT NUMBER 18 PAGES 2237-2382 September 15, •996

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Contents GENES & DEVELOPMENT September 15, 1996

Review

Propagation of traveling waves in excitable media Brian M. Sager

2237

Research papers

Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade Mickey C.-T. Hu, Wan R. Qiu, Xiaoping Wang, Christian F. Meyer, and Tse-Hua Tan

2251

Opposing pairs of serine protein kinases and phosphatases transmit signals of environmental stress to activate a bacterial transcription factor Xiaofeng Yang, Choong Min Kang, Margaret S. Brody, and Chester W. Price

2265

Conjugation, meiosis, and the osmotic stress response are regulated by Spcl kinase through Atfl transcription factor in fission yeast Kazuhiro Shiozaki and Paul Russell

2276

The Atfl transcription factor is a target for the Styl stress-activated MAP kinase pathway in fission yeast Marc G. Wilkinson, Michael Samuels, Tadayuki Takeda, W. Mark Toone, Jia-Ching Shieh, Takashi Toda, Jonathan B.A. Millar, and Nic Jones

2289

Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins Bruce Schnepp, Gary Grumbling, Timothy Donaldson, and Amanda Simcox

2302

Caenorhabditis elegans sex-determining protein FEM-2 is a protein phosphatase that promotes male development and interacts directly with FEM-3 Ian D. Chin-Sang and Andrew M. Spence

2314

In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-l l and Hoxd-lO expression boundaries Matthieu G4rard, Jia-Yang Chen, Hinrich Gronemeyer, Pierre Chambon, Denis Duboule, and J6zsef Zfikany

2326

Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1 Abraham L. Brass, Eli Kehrli, Charles F. Eisenbeis, Ursula Storb, and Harinder Singh

2335

Three sites of contact between the Bacillus subtilis transcription factor ~r F and its antisigma factor SpoIIAB Amy Lynn Decatur and Richard Losick

2348

(continued)

Gene activation by recruitment of the RNA polymerase II holoenzyme Susan Farrell, N a t a s h a S imkovich , Yibing Wu, Alcide Barberis, and Mark P tashne

2359

Yeast TAFII90 is required for cell-cycle progression through G2/M but not for general transcription activation Lynne M. Apone, C h i n g - m a n A. Virbasius, Joseph C. Reese, and Michael R. Green

2368

Cover Propagation of traveling waves in excitable media. Shown are spiraling Belousov-Zhabotinsky (BZ) waves in a ferroin-catalyzed BZ reaction. (For details, see Sager, p. 2237.) (Photograph courtesy of Stefan M~iller.)