• Chairman, Department of Clinical Pathology and Nuclear Medicine • Chairman, Department of Pathology Pathologist & Director of Laboratories • Private Practice of Pathology • Consultant Pathologist • Pathologist & Director of Laboratories • Forensic Pathologist, Denver City & County • Assistant Professor, Department of Pathology, Colorado • Resident in Pathology, University of Colorado Medical Center • Captain, United States Army Medical Corps • Fellow: o College of American Pathologists o American Society of Clinical Pathologists o American College of Nuclear Physicians 1972-1990 . 1962 . 1959-1961 1956-1959 1953-1959 1951-1953 . 1951-1953 . 1949-1951 . 1943-1948 KRAFT: The man who decoded Diabetes and Heart Disease …many decades ago.
Transcript
• Chairman, Department of Clinical
Pathology and Nuclear Medicine
• Chairman, Department of Pathology
Pathologist & Director of Laboratories
• Private Practice of Pathology
• Consultant Pathologist
• Pathologist & Director of Laboratories
• Forensic Pathologist, Denver City &
County
• Assistant Professor, Department of
Pathology, Colorado
• Resident in Pathology, University of
Colorado Medical Center
• Captain, United States Army Medical
Corps
• Fellow:
o College of American Pathologists
o American Society of Clinical
Pathologists
o American College of Nuclear
Physicians
• 1972-1990
.
• 1962
.
• 1959-1961
• 1956-1959
• 1953-1959
• 1951-1953
.
• 1951-1953
.
• 1949-1951
.
• 1943-1948
KRAFT: The man who decoded Diabetes and Heart Disease
…many decades ago.
2015 Ivor Cummins BE(Chem) CEng MIEI
PROPERLY DIAGNOSING DIABETES
2015 Ivor Cummins BE(Chem) CEng MIEI
1. FASTING BLOOD GLUCOSE TEST
PROPERLY DIAGNOSING DIABETES
A. Overnight Fast
2015 Ivor Cummins BE(Chem) CEng MIEI
1. FASTING BLOOD GLUCOSE TEST
PROPERLY DIAGNOSING DIABETES
A. Overnight Fast B. Blood glucose level
2015 Ivor Cummins BE(Chem) CEng MIEI
1. FASTING BLOOD GLUCOSE TEST
PROPERLY DIAGNOSING DIABETES
B. Blood glucose levelA. Overnight Fast
A. Overnight Fast
2015 Ivor Cummins BE(Chem) CEng MIEI
1. FASTING BLOOD GLUCOSE TEST
PROPERLY DIAGNOSING DIABETES
B. Blood glucose levelMISSES MOST – AND
WAY TOO LATE !
A. Overnight Fast
2015 Ivor Cummins BE(Chem) CEng MIEI
1. FASTING BLOOD GLUCOSE TEST
PROPERLY DIAGNOSING DIABETES
B. Blood glucose level
2. GLUCOSE TOLERANCE TEST
A. 100g Glucose
MISSES MOST – AND
WAY TOO LATE !
A. Overnight Fast
2015 Ivor Cummins BE(Chem) CEng MIEI
1. FASTING BLOOD GLUCOSE TEST
PROPERLY DIAGNOSING DIABETES
B. Blood glucose level
2. GLUCOSE TOLERANCE TEST
B. Blood glucose level over timeA. 100g Glucose
MISSES MOST – AND
WAY TOO LATE !
A. Overnight Fast
2015 Ivor Cummins BE(Chem) CEng MIEI
1. FASTING BLOOD GLUCOSE TEST
PROPERLY DIAGNOSING DIABETES
B. Blood glucose level
2. GLUCOSE TOLERANCE TEST
B. Blood glucose level over timeA. 100g Glucose
MISSES MOST – AND
WAY TOO LATE !
A. Overnight Fast
2015 Ivor Cummins BE(Chem) CEng MIEI
1. FASTING BLOOD GLUCOSE TEST
PROPERLY DIAGNOSING DIABETES
B. Blood glucose level
2. GLUCOSE TOLERANCE TEST
B. Blood glucose level over timeA. 100g Glucose
MISSES MOST – AND
WAY TOO LATE !
MISSES MANY – AND
WAY TOO LATE !
2015 Ivor Cummins BE(Chem) CEng MIEI
1. Drink 100g of Glucose…
2015 Ivor Cummins BE(Chem) CEng MIEI
2. Measure the INSULIN response over time…
1. Drink 100g of Glucose…
2015 Ivor Cummins BE(Chem) CEng MIEI
2. Measure the INSULIN response over time…
1. Drink 100g of Glucose…
PROPER DIABETES DIAGNOSIS !
2015 Ivor Cummins BE(Chem) CEng MIEI
2015 Ivor Cummins BE(Chem) CEng MIEI
2015 Ivor Cummins BE(Chem) CEng MIEI
2015 Ivor Cummins BE(Chem) CEng MIEI
2015 Ivor Cummins BE(Chem) CEng MIEI
Insulin Response Pattern 1 is:
Euinsulinemia/Non-Diabetic
Insulin Response Pattern 1 is:
Euinsulinemia/Non-Diabetic
2015 Ivor Cummins BE(Chem) CEng MIEI
Insulin Response Patterns 2 to 4 are:
Hyperinsulinemia/Diabetes In Situ
These people are Diabetic. Period.
2015 Ivor Cummins BE(Chem) CEng MIEI
Insulin Response Patterns 2 to 4 are:
Hyperinsulinemia/Diabetes In Situ
These people are Diabetic. Period.
Kraft tested
14,384 people
2015 Ivor Cummins BE(Chem) CEng MIEI
Insulin Response Patterns 2 to 4 are:
Hyperinsulinemia/Diabetes In Situ
These people are Diabetic. Period.More than
75% of the
people with
‘normal’ glucose results, failed
Kraft’s test. They were NOT ok.
Kraft tested
14,384 people
2015 Ivor Cummins BE(Chem) CEng MIEI
Insulin Response Patterns 2 to 4 are:
Hyperinsulinemia/Diabetes In Situ
These people are Diabetic. Period.
Kraft tested
14,384 people
They were
Diabetic
More than
75% of the
people with
‘normal’ glucose results, failed
Kraft’s test. They were NOT ok.
2015 Ivor Cummins BE(Chem) CEng MIEI
Critically, Kraft’s research and >3,000 autopsies
(personally conducted) led him to infer that:
2015 Ivor Cummins BE(Chem) CEng MIEI
• The damage of diabetes is
vascular: you must assume
diabetes is the root cause,
unless Pattern 1 demonstrated!
Critically, Kraft’s research and >3,000 autopsies
(personally conducted) led him to infer that:
2015 Ivor Cummins BE(Chem) CEng MIEI
• The damage of diabetes is
vascular: you must assume
diabetes is the root cause,
unless Pattern 1 demonstrated!
• The damage precedes the point
where the glucose becomes
elevated (ref: Kimmelsteil’s work)
Critically, Kraft’s research and >3,000 autopsies
(personally conducted) led him to infer that:
2015 Ivor Cummins BE(Chem) CEng MIEI
• The damage of diabetes is
vascular: you must assume
diabetes is the root cause,
unless Pattern 1 demonstrated!
• The damage precedes the point
where the glucose becomes
elevated (ref: Kimmelsteil’s work)
• This diabetic-driven disease is
observed in all vessels, incl. micro
vessels of the heart’s IV Septum
Critically, Kraft’s research and >3,000 autopsies
(personally conducted) led him to infer that:
2015 Ivor Cummins BE(Chem) CEng MIEI
• The damage of diabetes is
vascular: you must assume
diabetes is the root cause,
unless Pattern 1 demonstrated!
• The damage precedes the point
where the glucose becomes
elevated (ref: Kimmelsteil’s work)
• This diabetic-driven disease is
observed in all vessels, incl. micro
vessels of the heart’s IV Septum
In summary, Kraft concluded that:
“Those with cardiovascular disease not identified
with diabetes…are simply undiagnosed.”
Critically, Kraft’s research and >3,000 autopsies
(personally conducted) led him to infer that:
2015 Ivor Cummins BE(Chem) CEng MIEI
Kraft in Summary:1.Diabetic phenomena are grossly under-
diagnosed in the population
2.The earliest diagnosis is with the ‘5 hour glucose
with insulin assay’ (although 2hr insulin can serve
as a proxy)
3.The diabetic state can be effectively addressed
with diet, rescuing people from Pattern 2-4
(Diabetes in Situ)
4.Cardiovascular Disease is primarily a diabetic
pathology – all so afflicted should be assumed
diabetic, unless they achieve Pattern 1…
5.The vascular disease of Penile Erectile
Dysfunction (PED), is also a diabetic pathology –
all so afflicted should be assumed diabetic, unless
