Download Detailed Syllabus

I.E.C. UNIVERSITY

BADDI (SOLAN) H.P.

MASTERS OF SCIENCE (M. Sc)

Chemistry

I.E.C. UNIVERSITY

BADDI (SOLAN) H.P.


Chemistry

I.E.C. UNIVERSITY

BADDI (SOLAN) H.P.


Chemistry

INDEX

1. Programme Objectives

2. Programme Outcomes

3. Academic Regulations

4. Flexible Credit base system

5. Proposed Scheme of Evaluation

6. Detailed syllabus semester wise

M. Sc (CHEMISTRY) MISSION

Two year full time (Semester system I II III and IV) M.Sc. programme in Chemistry.

Science is basic foundation of any technological and engineering creation. In view of thechanging scenario at national and international level in field of Science and Technology, there isgreat demand for basic sciences with considerable knowledge of its applications. VNIT iscommitted to high academic standards. The M.Sc. courses are designed for four semesters (twoyears) in such a way that a good basic foundation of subjects is laid and applications along withrecent developments are covered. Relative grading will be followed and credits will be allottedbased on academic performance. Students will also get theoretical and practical knowledge ofcomputer programming. These M.Sc. programmes provide opportunity to make career in R&D,industries and academic institutions. Opportunity for the placement may be provided by theInstitute.

M.Sc. (Chemistry) Programme Objectives:

The special feature of M.Sc. (Chemistry) is a good foundation of basics and research componentthrough practical and theoretical knowledge, which in turn will provide excellent job prospects inAcademics, Industries and other field of interest. Department of Chemistry has highly qualified,motivated, dynamic and experienced faculty members. The M.Sc. (Chemistry) programmeintended to offer a balanced combination of core and applied courses of Chemistry. M.Sc.(Chemistry) will provide competence to tackle frontier area in Green chemistry, NanoChemistry, Supramolecular Chemistry, Sensors, Advanced materials, Bio-Physical, Bio_organicand Bio-Inorganic, Spectroscopy and Advanced organic chemistry (Natural product synthesis).The course and syllabus are designed in such a manner that the students become expertise in thefield of Chemicals (synthesis as well as production/manufacturing). Two years M.Sc programmein Chemistry will be conducted in four semesters. To aid in teaching career, NET syllabus iscovered. There will be a seminar and a project. Various materials courses of this programme willbe of great help for shaping a career in research and industry.

This will be useful in developing awareness, aspiration and innovative ability to solve newscientific problems. The department has well equipped labs to provide practical skills to students.Fourth semester has one electives course. Six electives have been incorporated in the courseconsidering variety of advanced interest.

PROGRAMME OUTCOMES

An increased knowledge of the theories and concepts in two major areas of chemistry,one of which being the student’s major area of emphasis

An understanding of and the ability to apply the fundamentals of research methodologyand statistical analysis to the interpretation and evaluation of scientific data.

The ability to communicate knowledge of chemistry both orally and in writing, includingresearch reports

Complete a research project, write a thesis based on the project and defend the projectbefore thesis committee.

Academically prepared for a Academics, Industries and other field of interest as career

The ability to function effectively in a diverse and global academic and industrialrequirement

ACADEMIC REGULATIONS

PREAMBLE

M. Sc programme under Flexible Credit System Based (FCBS) shall adopt a Semestersystem. There will be two semesters in an academic year. Normally the ODD semesterwill be from July to December & Even Semester from December to May.

As part of our objective of providing quality education & making the graduatesemployable, IEC University is taking up the step in this direction by introducing theFlexible Credit Based System (FCBS).

Thus, the students can register courses of their choice & alter the pace of learning withinthe broad framework of academic programmes & credit requirements.

Students can register courses according to their interest & academic ability in completingthem.

FCBS allows students in deciding their academic plan & permits students to alter it asthey progress during the programme.

The academic counsellor helps the students in identifying the courses based onprogramme requirement, course pre requisite, students’ ability & interest in variousacademic disciplines.

The extract of PG Academic regulations given hereunder is for general information, &the students are advised to go through the detailed regulations of the programme in whichhe/she is admitted.

ADMISSION AND ENROLMENT OF STUDENTS

• Admission shall be done on the basis of merit, providing for reservations in accordancewith the Act.

• The merit shall be determined by the marks obtained by the candidates in qualifyingexamination

ELIGIBILITY CRITERIA FOR ADMISSION

Qualification B.Sc.(10+2+3) degree (Major/Honours) in Chemistry withMathematics, Physics and Biology for at least twoyears/four semesters, with a minimum of 50% marks or5.5 CPI in a 10-point scale (45% marks or 5.0 CPI in a 10-point scale for SC/ST/PD candidates) in major/honoursonly

OR

Candidates having B.Sc.(10+2+3) degree without(Major/Honours) in Chemistry with Mathematics, Physicsand Biology for at least two years/four semesters, musthave the concerned degree with (a) Chemistry as a subjectfor at least two years/four semesters and Mathematics,Physics and Biology for at least one year/two semestersand (b) a minimum 50% aggregate marks or 5.5 CPI in a10-point scale for General/OBC category candidates and aminimum 45% aggregate marks or 5.0 CPI in a 10-pointscale for SC/ST/PD category candidates.

The candidate should also satisfy the conditions regardingminimum marks, the number of attempts in the qualifyingexamination & age as prescribed by the AICTE/UGC fromtime to time, & physical fitness as may be prescribed bythe Academic Council of the University.

Eligibility criteria for admission to Foreign Nationals (FN)/ Person Of Indian Origin(PIO)/

Children Of Indian Workers In Gulf Countries ( CIWGC) In PG/ Integrated Programmes

The FN/ PIO/ CIWGC students shall meet the eligibility conditions outlined above.

The qualifying examinations passed by FN/ PIO/ CIWGC students should be considered

equivalent to eligibility examinations by the Association of Indian Universities/

Academic council.

The candidate should also satisfy other conditions as prescribed by the AICTE/UGC from

time to time, & physical fitness as may be prescribed by the Academic Council of the

University.

Note: The candidates appearing in the qualifying examinations are also eligible to apply,

subject to the condition that they must fulfil the eligibility criteria as given above at the time

of registration in the programme.

MEDIUM OF INTRUCTION AND EXAMINATIONS

The medium of instructions and examination shall be English in all the programmes, except in

language courses where it is necessary to use the corresponding mediums.

UNIVERSITY FEE

Every student has to deposit his total Fee, other charges and dues, if any, in the beginning of the

semester at the time of Registration, failing which he will not be permitted for registration in the

programme.

FELLOWSHIPS, SCHOLARSHIPS, STIPENDS, MEDALS AND PRIZES

Fellowships, Scholarships, Stipends, Medals and Prizes may be instituted by the University and

awarded as per rules.

REGISTRATION

• Every Student will register every semester for courses that he wishes to pursue in that

semester.

• A non-registered student will not be allowed to attend classes and take examination even

if he has paid the fees.

• The late registration of a freshman who is admitted after the start of the semester may

be done at the time of admission by the authorized official.

Adding and Dropping of Courses

• A student may be permitted to add or drop course(s) within two weeks of the beginning

of the semester.

• In case a student has been allowed to change the course or programme during the

current semester by the University, the classes attended in the previous course

may also be considered in calculation of attendance to determine the eligibility for

appearing in ESE.

MID – TERM MIGRATION OF STUDENTS

• Inter-university migration shall not be allowed in normal circumstances.

• Under exceptional circumstances, mid-term transfer of a student from any other

University to IEC University may be permitted on a case to case basis. In all such

cases, the approval on the transfer of relevant credits the student has already earned

in that University may be granted by the Academic Council.

TRANSFER OF PROGRAMME

A student once admitted and registered in a programme will not be allowed to

change the programme under any circumstances.

ACADEMIC SYSTEM

• The University will follow semester system in all of its PG/ Integrated programmes.

Summer Semester

• The Vice Chancellor may decide to hold a Summer semester on the

recommendation of the Academic Advisory Committee.

• Summer semester is a special privilege to be offered at the discretion of the University,

and the University will not be under any obligation to offer summer semester every

year.

• Summer semester, if offered, may be allowed only for students who are not ondisciplinary probation.

• A list of courses to be offered in the summer semester is brought out during the evensemester before the ESE. Only a few selected courses as decided by the University maybe offered during the summer semester.

• A course may be offered in the Summer semester if there are a minimum of ten studentsregistering for it.

• Unless prescribed otherwise in the Regulations of any specific programme, theSummer semester is a fast-paced semester where all the rules for the normalsemester shall apply but the registration shall be limited to three courses having totalcredits not exceeding 12.

• The Summer semester may be of about seven to eight weeks duration and each coursemay run on about two times the normal load, thus imparting equivalent to about 16weeks of teaching, but at an accelerated pace.

• Whenever possible, the deficient students may be allowed to register for backlogcourses and/ or marginal courses (in which they have obtained D grade) in the Summersemesters on payment of necessary fees per course.

• A student can normally register only for backlog or marginal courses for the Summersemester.

• In view of the short duration of the Summer semester, late registration and adding anddropping of courses are not permitted beyond three days of the start of classes

Academic Counsellor

• Upon joining the University, each student will be assigned an Academic Counsellor.

• The Academic Counsellor will discuss with the student his academic performance in

previous semester(s) and suggest the number and nature of courses the student should

register during the ensuing semester, within the framework of that Programme

curriculum.

• The Academic Counsellor may advice students having many backlog courses to register

for lesser number of credits (subject to the minimum credits specifications) and prepare a

revised plan of study for the student with a slower pace.

Curriculum

Each programme contains a prescribed course structure which is generally calledCurriculum.

These courses will be offered to a student in a pre determined manner in eachsemester.

Students are expected to take course in each semester & clear them to variousconditions prescribed in this regulation.

Syllabus

• A course syllabus is a document that explains what a student is going to study in that

course.

• Each course will have a course code, course title, Lecture- Tutorial- Practical- Credit

(LTPC) distribution indicating the weightage of the course, version of syllabus revision,

course pre-requisites/ anti-requisites/ co-requisites (if any), course objectives, expected

outcome, short and detailed description of the topics, suggested text and reference books,

the mode of evaluation adopted, the effective date of application of the revised version of

the syllabus.

Course Plan

• A course plan consists of a list of lectures/ experiments carried out in each instructional

class/ lab by the course teacher during the semester as per the LTPC of the course, with

details like mode of delivery, reference material used, etc.

• One hour of lecture/ tutorial classes or two hours of laboratory work/ seminar/ practical/

group discussion per week constitutes ONE credit for the course. Separate course plans

need to be prepared for the theory and laboratory portions of any course, if the course has

an embedded lab component.

Example:

An LTPC of 2-1-2-4 means 2 hour of class room lecture; one hour of tutorial and

one hour of laboratory, all delivered within a calendar week. This course will have 4

credits.

Credits

Maximum Credit: 92

Maximum Credits: 135

Project/ Thesis/ Dissertation:

• Wherever required in the PG/ Integrated programme, all students of that programmes

should successfully complete Project/ Thesis/ Dissertation work.

• A student has to select a thesis supervisor at the beginning of the last year of the

programme, if not done earlier.

• A student shall not normally have more than two supervisors at any given time.

• Thesis supervisor(s) of a student will normally be appointed from amongst the faculty

members of the University using modalities decided by the departments.

• A student can have a co-supervisor from outside the University on the recommendation

of the Supervisor and with approval of the Director of the Institute.

• In case there has been a change/addition in the supervisor(s), the thesis will not be

submitted earlier than three months from the date of such change.

• Normally, a faculty member shall not supervise more than five individual PG candidates.

However the department may evolve a transparent policy for the distribution of PG

students amongst the faculty members in the department.

• In case a faculty member is suspended / debarred for indulging in lowering the prestige of

the University in any manner, he shall cease to be a thesis supervisor.

• If a supervisor resigns/ expires/ leaves the University, alternative/ caretaker supervisor be

appointed by the Departmental Postgraduate Committee (DPGC.)

• Submitting a thesis that was bought (purchased)/ borrowed/ thesis submitted in another

University/ Institution shall be considered as examination malpractice and will be

awarded an ‘F’ grade.

• Students have the responsibility to decide on the specific thesis area and title, and carry

out substantial portion of the literature survey at the beginning of their final year.

• Various time limits specified for monitoring and evaluation of performance of the

student, to be announced by the University in each semester, should be strictly followed.

Industrial/Practical Training

Wherever required in the programme, all the students of that programme should

undergo industrial/ practical training ina reputed industry in, anytime after one year of

study. This is listed in course structure.

Students who have completed their training are required to register for industrial/

practical training in the following semester for award of the grades.

Minimum/ Maximum Credit Limits for Course Registration

• The Average Academic Load in a regular semester will be of 23 credits.

• However, a fast pace student can register for a maximum of 28 credits.

• Similarly a slow pace student can register for a minimum of 16 credits in a regular

semester (other than during Summer semester).

• Under no circumstances, a student will be permitted to cross these limits.

• A student carrying out the last registration of his Programme will be permitted to register

less than 16 credits if the minimum credit requirements for the completion of Programme

so require.

• The average number of credits a student can register during a Summer semester shall be

between 6 and 8, or 2 courses.

• However, in special cases, the student may be permitted to register a maximum of 12

credits during a Summer semester.

• There is no minimum number of credits fixed for course registration during Summer

semester.

Course Prerequisites / Anti-requisites/ C-requisites

Some courses may have specific prerequisites to be met before a student can register for the

course in the current semester.

• Students who had received an ‘F’ grade in a prerequisite course are also permitted to

register the next level course by assuming that they had attained the required ‘exposure’

by attending that course.

• This stand is adopted so that the student can make further progress towards earning

credits and his progress need not be pulled down by backlog courses. Thus, concurrent

registration of a prerequisite and next level course becomes a possibility.

• Similarly, a course may have an anti-requisite and/ or co-requisite.

• When two courses having almost similar/ same course contents and considered as

equivalent are made available to a student to choose within a group, and to prevent

students crediting both the courses, the anti-requisite option can be used.

• Similarly, an independent laboratory course can be coupled with a theory alone course

through a co-requisite thereby forcing a student to register both the courses together.

PG Teaching Experience

To provide an opportunity to Final year students having current CGPA 8.50 or more,

value-addition schemes are available in the University.

Such students may be awarded tutoring assignments in the lower year courses.

Such contributions will be duly recognized by providing financial support and making a

mention in the Grade sheets.

Vice Chancellor’s List

• Students who maintain a CGPA of 9.50 and above, starting from the beginning of 3rd

semester results and subsequently, having no ‘F’ grade to their credit, having never

debarred for lack of attendance in any ESE or indiscipline, will be placed on Vice

Chancellor’s List for their meritorious performance.

• Their name will be removed from the Vice Chancellor’s List if their CGPA falls

below 9.50 or they receive an ‘F’ grade or are debarred due to lack of attendance in

any ESE or an act of indiscipline subsequently.

• Such students will be accorded benefits/ recognition as per rules.

Conversion Factor for Converting CGPA into Marks Equivalent

If a conversion to marks is required, the following formula may be used to calculate the

same:

The Equivalent Percentage of Marks = CGPA* 9.0 + 5

ATTENDANCE REQUIREMENTS

• A student must have 75% or more attendance in aggregate of delivered classes, in all

registered courses of theory (lectures plus tutorial) and practicals (including

workshops training, seminar, projects, industrial training etc.) of the concerned

semester.

• Only such students who fulfill the above 75% attendance criteria will be permitted to

appear in End Semester Examination (ESE).

• The cases of students having attendance less than 75% but more than or equal to 60%

shall be reviewed by the University on a case to case basis as per the Ordinance.

• If a student’s attendance falls below 60%, for any reason including medical, he will not be

allowed to appear in the ESE of any course registered in the semester. He will be awarded

‘F’ grades in all the courses of that semester.

• Calculation of attendance for determining the eligibility to appear in ESE will be based

on the date of actual registration of the candidate, if late registration is permitted by the

University.

COMPONENTS OF EVALUATION

• In general, a course will have three components of evaluation viz. Continuous

A ssessment (CA), Mid-Semester Exams (MSE), and End- semester Exam (ESE),

• CA will carry 40 Marks [Tutorials 10 Marks, Quizzes10 Marks, Assignments10 Marks,

and Projects/ Case studies/ Viva voce 10 Marks]

• MSE will carry 20 marks.

• First MSE to be held after completion of 35% - 40% course coverage.

• Second MSE to be held after completion of 70% - 80% course coverage.

• ESE will carry 40 marks.

SYSTEM OF EVALUATION BASED ON BROAD BAND GRADES

• The University shall follow the Broad-band Grades systems for various PG

programmes as specified in the respective Programme detail.

• The course credit (C), number of lectures, tutorials, practicals (L), (T), (P) in a course are

related as C = (L + T + 0.5 P)

• The students will be awarded grades using relative grading in a course and result

cards will show individual course grades, the course credits and the overall

weighted performance indices such as SGPA (Semester Grade Point Average) and

CGPA (Cumulative Grade Point Average).

• The following broadband letter grades will be used to report a student’s performance on

a 10-point scale.

• The letter grades and their numerical equivalents on a 10-point scale (called Grade

Points) are as follows:

Letter

Grade

A AB B BC C D F

Grade

Points

10 9 8 7 6 4 0

• In addition to the above, there are three letter grades viz., I, S, and X which stands for

Incomplete, Satisfactory, and Unsatisfactory, respectively.

• For courses with zero weightage (audit) only satisfactory (S)/ Unsatisfactory (X) grades

are awarded.

• No student shall be awarded ‘A’ grade in any course unless he has secured a minimum

of 80% marks in the total of all components of evaluation in that course.

• No students shall be awarded ‘F’ grade in any course if he has secured a

minimum of 40% marks in the total of all components of evaluation in that course.

• In case a student repeats a particular course during summer semester along with his

juniors, he will be awarded only up to a maximum of AB grade based on his current

performance and the grade he obtained earlier.

• The statistical method shall invariably be used with marginal adjustment for the

natural cut off if the number of students appearing in a course is 60 or more. The

mean and standard deviation (σ) of marks obtained of all the students in a course

shall be calculated and the grades shall be awarded to a student depending upon the

marks and the mean and the standard deviation as per Table given below:

Lower Range of Marks Grade Upper Range of Marks

A ≥ Mean + 2.5 σ

Mean + 1.5 σ ≤ AB < Mean + 2.5 σ

Mean + 0.5 σ ≤ B < Mean + 1.5 σ

Mean - 0.5 σ ≤ BC < Mean + 0.5 σ

Mean - 1.5 σ ≤ C < Mean - 0.5 σ

Mean - 2.5 σ ≤ D < Mean - 1.5 σ

F < Mean - 2.5 σ

• If the number of students appearing in any course is less than 60, the grades in that

course will be awarded in the following manner :

Marks Obtained in a course out of 100 (M) Letter Grade

85 <= M <= 100 A

75 <= M <= 84 AB

65 <= M <= 74 B

55 <= M <= 64 BC

50 <= M <= 54 C

40 <= M <= 49 D

M <= 39 F

Incomplete I

• A student may be awarded the grade ‘I’ (Incomplete) in a course if he has missed the

ESE for a genuine reason.

• This grade must, however, be converted by the Faculty-In-Charge into an appropriate

letter grade within ten days from the completion of ESE.

• Any ‘I’ grade still outstanding two days after the prescribed last date, shall be

automatically be converted into ‘F’ grade.

• The course(s) in which a student has earned ‘F’ grade will be termed as back-log

course(s), which he has to improve by repeating/ replacing the course(s) as per the

rules.

• ‘F’ grade is also awarded to a student who is not allowed to/ do not appear in ESE in a

particular subject due to shortage of attendance, though he might have undergone

other components such as MSE, assignments, class tests, projects, etc.

• Such a student will be required to repeat the course in the Summer semester in which he

has secured ‘F’ grade.

• The Semester Grade Point Average is a weighted average of the grade points earned by

a student in all the courses credited and describes his academic performance in a

Semester. If the grade point associated with the letter grades awarded to a student are

say, g1, g2, g3,………. and the corresponding weightage is (credits) are say, w1, w2,

w3,………. the SGPA is given by:

• The Cumulative Grade Point Average indicates overall academic performance

of a student in all the courses registered up to and including the latest

completed Semester. It is computed in the same manner as SGPA, considering

all the courses (say, n), and is given by:

CGPA=∑ {credit of semester*SGPA of semester}/total credits

• The minimum CGPA requirement for the award of an Post Graduate degree/ diploma/

certificate will be 5.5 subject to getting ‘D’ or above grade in each of the courses

individually.

• A minimum of 4.5 SGPA in a UG programme is required in each semester for moving

to the higher semester.

• A student will not be allowed to move to higher Semester without clearing the

backlog courses so as to obtaining the required minimum SGPA and/ or CGPA.

• A student will be required to get grade ‘D’ or above in a course for passing in the

course.

• A student will be issued a Cumulative Grade Card at the end of each semester

indicating the grades secured for all the registered courses up to and including the

last semester.

EXAMINATION

• The period of Examination(s) (Mid semester and End semester) shall be as specified in

the Academic Calendar.

• All students who have registered for a particular course are eligible to write the ESE of

that course, except if he is declared ineligible due to one or more of reasons listed

below.

1. Shortage of attendance

2. Acts of indiscipline

3. Withdrawal of a course from Registration

• Make-up examinations are special examinations conducted for students who could not

take regularly scheduled examination and have been awarded the ‘I’ grade or

‘Incomplete’ result.

• Make–up examination is a special privilege to be offered at the discretion of the

University and the University will not be under any obligation to allow a student a

make-up examination. The student(s) shall have no right to cite the non-availability of

this facility as an excuse for his/ their poor performance.

• Make-up Examination for MSE and/ or ESE may not be allowed to students on

disciplinary probation

• A student, who has missed one or more papers in a regular examination because of a

genuine medical reason, may be permitted in Make-up Examination as per rules.

• A student appearing in a make up examination for ESE and/ or MSE in any course shall

not be awarded ‘A’ grade in that course.

• After valuation of MSE answer scripts, they will be handed over to students.

• Recounting of ESE answer scripts is permitted.

• There is no provision of re-evaluation of ESE answer scripts.

TERMINATION OF THE PROGRAMME

A student will be declared “Not Fit for the Programme (NFP)” and shall have to discontinue if

he does not satisfy following conditions:

After the completion of the First Year the student should have passed a minimum

of forty percent (40%) courses prescribed in the first year to be calculated after

the summer semester, if any.

Second Year onwards, the academic performance of a student is reviewed at the

end of every semester by the Academic Advisory Committee, and the decision is

taken on a case to case basis as per rules..

MAXIMUM DURATION FOR THE COMPLETION OF THE PROGRAMME

The maximum duration for completion of the degree/ diploma/ certificate, for the completion of the

course, subject to other conditions, shall be as follows:

Normal

Duration

Maximum Duration

Allowed

2 Years 4 Years

RESULT AND DIVISION

• A student will be issued a Cumulative Grade Card at the end of each semester

indicating the grades secured for all the registered courses up to and including the

last semester.

• The minimum CGPA requirement for the award of an Post Graduate degree/ diploma/

certificate/ integrated programme will be 5.5 subject to getting ‘D’ or above grade in

each of the courses individually.The result of a student may be withheld if,

(1) he has not paid all the dues, or

(2) if there is a case of indiscipline or use of unfair means or of

academic misconduct pending against him, or

(3) for any other reason as deemed fit by the University.

• Four divisions as defined below shall be awarded:

Division CGPA

First with Honors and

Certificate of Merit

> = 9.0

First with Honours > = 8.0 < 9.0

First > = 6.5 < 8.0

Second > = 5.0 < 6.5

• For securing degree/ diploma/ certificate in First Division with Honors and First

Division with Honors and certificate of Merit , a student shall have passed all the courses

(Theory and Practical) of the programme in the first attempt, i.e., without ever being

awarded a Re-appear or a Fail.

MAINTENANCE OF DISCIPLINE AMONG STUDENTS

• All powers relating to maintenance and enforcement of discipline in the University and

taking disciplinary action against the students and employees of the University shall vest

in the Vice-Chancellor, which he may delegate as he deems proper.

• All acts given in details in Ordinance shall amount to acts of indiscipline or misconduct

or ragging on the part of a student of the University and colleges / institutions.

• The University Authority in the exercise of the powers, order or direct that any student –

(a) be expelled from the University, college or institution, or

(b) be, for a stated period, rusticated or

(c) be not, for a stated period, admitted to a course or courses of study of the

University; or

(d) be imposed with the fine of a specified amount of money;

(e) be debarred from taking a University examination or examinations for one or

more years.

ACADEMIC MISCONDUCT AND USE OF UNFAIR MEANS

• Plagiarism, collusion and cheating are all forms of academic misconduct and use of

unfair means as defined in the Examination Ordinances.

• In case the student has come to examination under the influence of any

intoxicating material, misbehaves with one or more members of the supervisory

staff, it will also be treated as an act of Unfair Means and academic misconduct.

• In relation to continuous assessment, Academic misconduct and use of Unfair Means

is classified as Major Misconduct or Minor Misconduct as described below:

(1) Major Misconduct: Where plagiarism, collusion or cheating is detected in

Thesis, Dissertation or Major Project of a programme.

(2) Minor Misconduct: All other academic misconduct excluding those

defined in major misconduct will be regarded as a minor misconduct and will

be dealt accordingly.

• If the Unfair Means Board (UFMB) finds the student guilty, one of the following

actions may be taken:

(1) The student may be disqualified for one or more semester, or

(2) The student may be rusticated for one or more semester, or

(3) The academic programme of the student may be terminated.

(4) Any other action as deemed fit by the UMB.

RESIDUAL PROVISION

In case of any dispute/ difference of interpretation of provisions made in the Ordinances and

Regulations, the decision of the Chancellor shall be final.

A student earns a total of 92 (Ninety two) credits in four semesters. The course structureis as follows:

M.Sc. (Chemistry) Two Years Programme CurriculaFirst Semester Internal Ext.

S.No.

Sub Code Subject LectureHours/Sem(4L + 1T)

CA MST Total Total Credits

1. CHEM-501 In-Organic-I 60 20 40 60 40 4.5

2. CHEM -502 Organic-I 60 20 40 60 40 4.5

3. CHEM -503 Physical-I 60 20 40 60 40 4.5

4. MATH/BIO-103

Mathematics / Biology forChemists*

30/30 10 20 30 20 3

5. CHEM -551 Inorganic chemistry Lab I 60 10 20 30 20 2

6. CHEM -552 Organic chemistry Lab I 60 10 20 30 20 2

7. CHEM -553 Physical Lab-I 60 10 20 30 20 2

Total 22.5

M.Sc. (Chemistry) Two Years Programme CurriculaSecond Semester Internal Ext.

S.No.



1. CHEM -511 In-Organic-II 60 20 40 60 40 4.5

2. CHEM -512 Organic-II 60 20 40 60 40 4.5

3. CHEM -513 Physical-II 60 20 40 60 40 4.5

4. CSA-101 Fundamental of Computers 30 10 20 30 20 35. CHEM -554 Inorganic chemistry Lab II 60 10 20 30 20 2

6. CHEM -555 Organic chemistry Lab II 60 10 20 30 20 2

7. CHEM -556 Physical Lab-II 60 10 20 30 20 2

8. CSA-151 Computer lab-I 30 10 20 30 20 1Total 23.5

M.Sc. (Chemistry) Two Years Programme CurriculaThird Semester Internal Ext.

S.No



1. CHEM -601 Physical-III 60 20 40 60 40 4.52. CHEM -602 In-organic-III 60 20 40 60 40 4.53. CHEM -603 Organic-III 60 20 40 60 40 4.54. CHEM 604 Chemistry for life and

Environmental chemistry60 20 40 60 40 4.5

5. CHEM -651 Inorganic chemistry LabIII

60 10 20 30 20 2

6. CHEM 652 Organic chemistry Lab III 60 10 20 30 20 27. CHEM -653 Physical Lab-III 60 10 20 30 20 2

Total 24 24

*Mathematics for medical stream students and Biology for Non-Medical stream students.

*Mathematics for medical stream students and Biology for Non-Medical stream students.

Note: CA= Class assessment, MST = Mid Semester test, Ext. = External.

S.No Elective-I (Paper)1 Polymer Chemistry2 Chemistry of macromolecules3 Advanced Organo-metallics4 Medicinal Chemistry5 Advanced Quantum Chemistry6 Solid State Chemistry

OUTLINES OF TESTS, SYLLABI AND COURSES OF READING FOR M.Sc. FIRSTYEAR (SEMESTER-I and II) EXAMINATION OF 2012-2013.

Instruction: The question paper will consist of Three Sections A, B and C. The compulsoryquestion for Section A will be of 20 marks and consist of 10 parts of 2 marks each. The differentparts will be set to cover the entire syllabus uniformly. Section B will be of two sub-sectionswith six questions each, and each question will carry 5 marks. Student will attempt any fourquestions out of Six in each sub-section of Sections B. Sections-C is of two sub-section ,eachsub-section will have Four questions of 10 marks each out of which the candidate will berequired to attempt two questions from each sub-section.

M.Sc. (Chemistry) Two Years Programme CurriculaFourth Semester Internal Ext.

S.No

Sub. Code Subject LectureHours/Sem(4L + 1T)


1. CHEM -611 Bio-Physical & Bio-Inorganic

60 20 40 60 40 4.5

2. CHEM -612 Elective-I(specialization)

60 20 40 60 40 4.5

3 CHEM -Lab 654 Lab (Bio-Physical &Bio-Inorganic)

60 10 20 30 20 2

3. CHEM -655 Lab (Optional) 60 10 20 30 20 24. CHEM -691 Dissertation 15 -- -- 120 80 9

Total 22

Inorganic Chemistry-I

Paper: CHEM-501 (L:4, T:1, 4.5 credits)

Max marks (60+40) Time 3 hours

UNIT-I

Group theory: The concept of group, Symmetry elements and symmetry operations,Assignment of point groups to Inorganic molecules, Some general rules for multiplications ofsymmetry operations, Multiplication tables for water and ammonia, Representations (matrices,matrix representations for C2V and C3V point groups irreducible representations), Character andcharacter tables for C2V and C3V point groups. Applications of group theory to chemicalbonding (hybrid orbitals for σ-bonding in different geometries and hybrid orbitals for π-bonding.Symmetries of molecular orbitals in BF3, C2H4 and B2H6.

UNIT-II

Application of Group Theory in Vibrational Spectroscopy: A brief idea about Infrared andRaman scattering spectroscopy. Vibrational modes as basis of group representations w.r.t. SO2,POCl3, PtCl4

2- and RuO4. Mutual exclusion principle, Classification of vibrational modes (i.e.stretching and angle deformation vibrations w.r.t. SO2, POCl3 and PtCl4

2-.

UNIT-III

Non-Aqueous Solvents: Factors justifying the need of Non Aqueous solution Chemistry andfailure of water as a Solvent. Solution chemistry of Sulphuric acid: Physical properties, Ionic selfdehydration in H2SO4, high electrical conductance in spite of high viscosity, Chemistry ofH2SO4 as an acid, as an dehydrating agent, as an oxidizing agent, as an medium to carry out acid-base neutralization reaction and as a differentiating solvent. Liquid BrF3: Physical properties,solubilities in BrF3, self ionization, acid base neutralization reactions, solvolytic reactions andformation of transition metal fluorides. Chemistry of Molten salts as Non-Aqueous Solvents:Solvent properties, solution of metals, complex formation, Unreactivity of molten salts, Lowtemperature molten salts.

UNIT-IV

Inorganic Hydrides: Classification, preparation, bonding and their applications. Transitionmetal compounds with bonds to hydrogen, carbonyl hydrides and hydride anions. Classification,nomenclature, Wade’s Rules, preparation, structure and bonding in boron hydrides(boranes),carboranes, metalloboranes and metallocarboranes.

Books Recommended:1. Chemical applications of Group Theory – F.A.Cotton2. Inorganic Chemistry – Durrant and Durrant3. Symmetry in Chemistry- Jaffe and Orchin4. Non-aqueous solvents – H.Sisler5. Non-aqueous solvents – T.C.Waddington6. Non-aqueous solvents – Logowsky7. Advanced Inorganic Chemistry:Cotton & Wilkinson,Vth Edn.8. Concise course in Inorganic Chemistry- J.D.Lee9. Nature of Chemical Bond – L. Pauling10. Chemistry of Elements – Greenwood and Earnshaw11. Inorganic Chemistry – T. Moeller12. Inorganic Chemistry – J.E.Huheey 3rd Edn.13. Topics in Current Chemistry (Inorganic/Bio-Chemistry)–Vol. 64

ORGANIC CHEMISTRY-I

Paper: CHEM -502 (L:4, T:1, 4.5 credits)


Instruction: The question paper will consist of Three Sections A, B and C. The compulsoryquestion for Section A will be of 20 marks and consist of 10 parts of 2 marks each. The differentparts will be set to cover the entire syllabus uniformly. Section B will be of two sub-sectionswith six questions each, and each question will carry 5 marks. Student will attempt any fourquestions out of Six in each sub-section of Sections B. Sections-C is of two sub-section ,eachsub-section will have Four questions of 10 marks each out of which the candidate will berequired to attempt two questions from each sub-section.

.

UNIT-I

Nature of Bonding in Organic Molecules: Delocalized Chemical Bonding: Kinds of moleculeswith delocalized bond, cross- conjugation, resonance, pπ-dπ bonding (ylides). aromaticity: othersystems containing aromatic sextet, Aromatic systems with electron number other than six.Huckel rule, other aromatic compounds, hyperconjugation. Supramolecular chemistry:Introduction, Bonding other than covalent bond. Addition compounds, Crown ether complexesand Cryptands, Inclusion compounds, Cyclodextrins, Catenanes and Rotaxenes and theirapplications.

UNIT-II

Stereochemistry: Conformational analysis of cycloalkanes, decalins, effect of conformation onreactivity in acylic and cyclohexane systems. Steric strain due to unavoidable crowding.Elements of symmetry: chirality, molecules with more than one chiral center, threo and erythroisomers, methods of resolution, optical purity, enantiotopic and diastereotopic atoms, groups andfaces, Optical activity due to chiral planes, Optical activity in the absence of chiral carbon(biphenyls, allenes and spiranes), chirality due to helical shape. Asymmetric Synthesis: Principleand categories with specific examples of asymmetric synthesis including newer methodsinvolving enzymatic and catalytic reactions, enantio and diastereoselective synthesis.Stereoselective Reactions: Cyclopropanation, hydroboration, catalytic hydrogenation, and metalammoni reduction, stereoselective synthesis of (-) ephedrine and (+) φ- ephedrine. StereospecificReactions : Elimination of 2,3- dibromobutane densyl chloride(1,2-diphenyl-1-chloroethane),SN2 reactions at chiral carbon.

UNIT-III

Reaction Mechanism: Structure and Reactivity: Thermodynamic and kinetic requirements,Kinetic and Thermodynamic control, Hammonds postulate, Curtin-Hammett principle. Potentialenergy diagrams, transition states and intermediates.

Effect of structure on reactivity: resonance and field effects, steric effect. Quantitativetreatment: Hammett equation and linear free energy relationship, Substituent and reactionconstants, Taft equation. Methods: determining reaction mechanism.

UNIT-IV

(A) Aliphatic Nucleophilic Substitution: The SN2, SN1, mixed SN1 and SN2, SET mechanisms& SNi mechanism. The neighboring group mechanism, neighboring group participation by π andσ bonds, anchimeric assistance. Non-classical carbocations, phenonium ions, norbornyl system,common carbocation rearrangements-Wagner-Meerwein, Pinacol-Pinacolone and Demjanov ringexpansion and ring contraction. Nucleophilic substitution at an allylic, aliphatic trigonal and avinylic carbon. Esterification of carboxylic acid, transesterification, transetherification andpreparation of inorganic esters. Phase-transfer catalysis, and ultrasound, ambident nucleophile,regioselectivity.

(B) Aliphatic Electrophilic Substitution: Bimolecular mechanisms- SE2 and SEi. The SE1mechanism, electrophilic substitution accompanied by double bond shifts, halogenations ofaldehydes, ketones, acids and acyl halides. Effect of substrates, leaving group and the solventsystem on reactivity. Aliphatic diazonium coupling, Acylation at aliphatic carbon, alkylation ofalkene, Stork-enamine reactions

(C) Free radical reactions: Types of free radical reactions, free radical substitution mechanism,mechanism at an aromatic substrate, neighboring group assistance, Reactivity in aliphatic andaromatic substrates at a bridgehead and attacking radicals. Effect of solvents on reactivity.Allylic halogenation (NBS), oxidation of aldehydes to carboxylic acids, auto oxidation, couplingof alkynes and arylation of aromatic compounds by diazonium salts. Gomberg Bachmannreaction, Sandmeyer reaction, Hoffmann -Loffler- Freytag reaction, Hunsdiecker reaction.

Books Recommended:1. Advanced Organic Chemistry-Reactions, Mechanism and Structure, Jerry March, John Wiley.2. Advanced Organic Chemistry, F.A. Carey and R.J. Sundberg, Plenum.3. A Guide Book to Mechanism in Organic Chemistry, Peter Sykes, Longman.4. Structure and Mechanism in Organic Chemistry, C.K. Ingold, Cornell University Press.5. Organic Chemistry, R.T. Morrison and R.N. Boyd, Prentice Hall.6. Modern Organic Reactions, H.O. House, Benjamin.7. Principles of Organic Synthesis, R.O.C. Norman and J.M. Coxon, Blackie Academic and

Professional.8. Pericyclic Reactions, S.M. Mukherji, Macmillan, India.9. Reaction Mechanism in Organic Chemistry, S.M. Mukherji and S.P. Singh, Macmillan.10. Stereochemistry of Organic Compounds, D. Nasipuri, New Age International.11. Stereochemistry of Organic Compounds, P.S. Kalsi, New Age International.

PHYSICAL CHEMISTRY-I

Paper: CHEM -503 (L:4, T:1, 4.5 credits)


Instruction: The question paper will consist of Three Sections A, B and C. The compulsoryquestion for Section A will be of 20 marks and consist of 10 parts of 2 marks each. The differentparts will be set to cover the entire syllabus uniformly. Section B will be of two sub-sectionswith six questions each, and each question will carry 5 marks. Student will attempt any fourquestions out of Six in each sub-section of Sections B. Sections-D is of two sub-section ,eachsub-section will have Four questions of 10 marks each out of which the candidate will berequired to attempt two questions from each sub-section.

UNIT – I

Spectroscopy – I: Theory of nuclear magnetic resonance NMR phenomenon, the chemical shiftand its measurement. The fine structure (spin – spin coupling). Factors influencing chemical –shift and spin – spin coupling. Non - first – order spectra. Relaxation phenomena in NMR: spin –spin and spin – lattice relaxation processes. Line –width and rate processes. The nuclearOverhauser effect. An introduction to Fourier Transform NMR (FTNMR).Theory of Electron Spin Resonance (ESR) phenomenon. Fine and hyperfine structure of ESR.Zero – field splitting of ESR signal. Mapping of charge density on molecule (McConnellrelation). Mossbaur spectroscopy: a brief introduction ( isomer – shift, quadrupole interactionand magnetic hyperfine interaction).

UNIT - II

Spectroscopy – II: Rotational and vibrational spectra. Moment of inertia and rotational spectraof rigid and non – rigid diatomic molecules. Vibrational excitation effect.. Rotational spectra ofsymmetric - top molecules. Strak effect. Vibrational energy of diatomic molecules. Anharmonicoscillator, overtones and hot bands. Diatomic vibrator – rotator (P, Q and R – branches ofdiatomic vibrator – rotator). Rotational – vibrational spectra of symmetric – top molecules.Raman Spectroscopy: qualitative quantum theory of Raman scattering. Rotational Raman spectraof linear and symmetric – top molecules. Vibrational Raman spectra and mutual exclusionprinciple.

UNIT - III

Kinetics of complex reactions: Reversible / opposing reactions, consecutive / successivereactions, simultaneous side / parallel reactions, chain / free radical reactions viz. thermal (H2 –Br2) and photochemical H2–Cl2) reactions. Rice – Herzfeld mechanism of dissociation of organicmolecules viz. dissociation of ethane, decomposition of acetaldehyde as 3/2 or ½ order reactions.Kinetics of polymerization (molecular and free radical mechanisms). Reaction rates andchemical equilibrium, principle of microscopic reversibility, activation energy and activatedcomplex.

UNIT - IV

Theories of reaction rates: The kinetic theory of collisions, transition state theory, comparisonof collisions and transition state theories in simple gas reactions, steric factor, transmission –coefficient, steady – state hypothesis / transient phase theory, Lindmans theory of unimolecularreaction, the thermodynamic formulation of reaction rates.

Surface Reactions: Mechanism of surface reactions, unimolecular and bimolecular surfacereactions, Langmuir – Hinshelwood mechanism for gases onlyFast Reaction in aqueous solutions: Study of fast reactions by Stopped flow method (Principleand Theory). Absolute rate theory applied to fast reactions.

Books Recommended:1. Chemical Kinetics : K.J. Laidler2. Kinetics and Mechanism of Reaction Rates: A.Frost and G. Pearson.3. Modern Chemical Kinetics: H. Eyring4. Theories of Reaction Rates: K.J. Laidler, H. Eyring and S. Glasston5. Fast Reactions: J.N. Bradly6. Fast Reactions in Solutions: Caldin7. Basic Principles of Spectroscopy: R. Chang8. NMR and Chemistry: J.W. Akit9. Introduction to Molecular Spectroscopy: G.M. Barrow10. Physical Chemistry: P.W. Atkins11. Fundamentals of Molecular Spectroscopy: C.N. Banwell

MATHEMATICS FOR CHEMISTS AND BIOLOGY FOR CHEMISTS

Paper: BCM-103 (L:2, T:0, 2 credits)



UNIT - ICartesian coordinates: plane polar coordinates, spherical representation of functions, the complexplane, polar coordinates in trigonometric functions. Differential calculus: functions of single andseveral variables, partial derivatives, the total derivative, maxima and minima theorem, andsimple examples related to chemistry. Concept of normalization, orthogonality and complete setof unit vectors.

UNIT – II

Integral Calculus: The Anti-derivative of a Function. The Process of Integration IndefiniteIntegrals: Tables of Integrals Improper Integrals Methods of Integration Numerical IntegrationProbability Distributions and Mean Values. Differential Equations Differential Equations andNewton's Laws of Motion, the Harmonic Oscillator Differential Equations with SeparableVariables Exact Differential Equations Solution of Inexact Differential Equations by the Use ofIntegrating Factors Partial Differential Equations: Waves in a String Solution of DifferentialEquations with Laplace Transforms Numerical Solutions of Differential Equations

UNIT – III

Matrices and Determinants: Definition of matrix, types of matrices (row, column, null, square,diagonal). Matrix algebra: addition, subtraction, and multiplication by a number, matrixmultiplication.Transpose and adjoint of matrix, elementary transformation, representation andapplications to solutions of linear equations. Definition of determinant, and its properties,evaluation of determinants. Application to simple chemistry problems.

UNIT – IV

Operators, Matrices, and Group Theory Operators and Operator Algebra Symmetry OperatorsMatrix Algebra Matrix Algebra with Mathematics An Elementary Introduction to Group Theory,The Solution of Simultaneous Algebraic Equations Simultaneous Equations with More thanTwo Unknowns Cramer's Rule Solution by Matrix inversion. The Use of Mathematics to SolveSimultaneous Equations, Mathematical Series and Transforms Constant Series FunctionalSeries Fourier series, Mathematical Operations on Series Integral Transforms

Books Recommended:

1. Mathematical Preparation for Physical Chemistry: F. Daniel2. Mathematical Methods forScience Students: G. Stephemen2. Applied Mathematics for Physical Chemistry: T.R. Barrante

3. Mathematics for Physical Chemistry: Robert Mortimer*.

BIOLOGY FOR CHEMISTS

Paper: BCB-103 (L:2, T:0, 2 credits)



UNIT-I

Cell structure and function: Overview of metabolic processes (catabolic and anabolic), energytransfer processes, role and significance of ATP (the biological energy currency). Introductoryidea of metabolism of proteins and lipids, biosynthesis of proteins and glycerides.

UNIT-II

Nucleic acids: Chemical constitution of nucleic acids: chemical structure of nitrogenous bases inDNA & RNA, base pairing, Structure of ribonucleic acids (RNA) and deoxyribonucleic acids(DNA), double helix model of DNA and forces responsible for holding it. Chemical andenzymatic hydrolysis of nucleic acids. The Chemical basis for heredity, transcription, translationand genetic code. Chemical synthesis of mono and tri-nucleoside.

UNIT-III

Introduction to photosynthesis: various plant pigments, Chemical structure of chlorophyll,Photo-system I & II, role of electron transport chain in photosynthesis,

UNIT-IV

Enzymes: Definition, classification on the basis of chemical composition & functions, mode ofaction of enzymes (Lock and key hypothesis), Cofactors, vitamins and Hormones (briefintroduction including definition, classification on the basis of chemical composition andfunctions).

Books Recommended:

1. Principles of Biochemistry –A.L.Lehringer2. Introduction to Chemistry of Life-H.J.DeBay3. Outlines of Biochemistry-Conn and Stumpf.

(INORGANIC CHEMISTRY-II)

Paper: CHEM-511 (L:4, T:1, 4.5 credits)Max marks (60+40) Time 3 hours


UNIT-I

Metal-Ligand Bonding-I: Recapitulation of Crystal Field Theory including splitting of d-orbitals in different environments, Factors affecting the magnitude of crystal field splitting,structural effects (ionic radii, Jahn-Teller effect), Thermodynamic effects of crystal field theory(ligation, hydration and lattice energy), Limitations of crystal field theory, Adjusted Crystal FieldTheory (ACFT), Evidences for Metal-Ligand overlap in complexes, Molecular Orbital Theoryfor octahedral, tetrahedral and square planar complexes (excluding mathematical treatment)

UNIT-II

Atomic Spectroscopy: Energy levels in an atom, coupling of orbital angular momenta, couplingof spin angular momenta, spin orbit coupling, spin orbit coupling p2 case, Determining theGround State Terms-Hund’s Rule, Hole formulation (derivation of the Term Symbol for a closedsub-shell, derivation of the terms for a d2 configuration), Calculation of the number of themicrostates.

UNIT-III

Electronic Spectra-I: Splitting of spectroscopic terms (s,p,d.f and g,h,i), d1-d9 systems in weakfields (excluding mathematics), strong field configurations, transitions from weak to strongcrystal fields.

Electronic Spectra-II: Correlation diagrams (d1-d9) in Oh and Td environments spin-cross overin coordination compounds. Tanabe Sugano diagrams, Orgel diagrams, evaluation of B, C and βparameters.

UNIT-IV

Magnetochemistry: Origin of Magnetic moment, factors determining paramagnetism, pplicationof magnetochemistry in co-ordination chemistry (spin only moment, Russell Saunder’s coupling,quenching of orbital angular moment, orbital contribution to a magnetic moment) in spin freeand spin paired octahedral and tetrahedral complexes. Magnetic susceptibility (diamagnetic,paramagnetic), magnetic moments from magnetic susceptibilities, Van Vlecks formula formagnetic susceptibility, temperature dependence of magnetic susceptibility.

Books Recommended:1 Advanced Inorganic Chemistry – Cotton and Wilkinson2 Coordination Chemistry- Experimental Methods – K.Burger3 Theoretical Inorganic Chemistry – Day and Selbin4 Magnetochemistry – R.L.Carlin5 Comprehensive Coordination Chemistry – Wilkinson, Gillars and McCleverty.6 Inorganic Electronic Spectroscopy – A.B.P.Lever7 Concise Inorganic Chemistry – J.D.Lee8 Introduction to Ligand Fields – B.N.Figgis9 Physical Methods in Inorganic Chemistry-R.S.Drago10 Introduction to Magnetochemistry – A.Earnshaw, Academic Press.

(ORGANIC CHEMISTRY-II)



UNIT – I

(A) Aromatic Electrophilic Substitution: Arenium ion mechanism, orientation and reactivity,energy profile diagrams, The ortho/para ratio, ipso attack, orientation in other ring systems.Quantitative treatment of reactivity in substrates and electrophiles, Diazonium coupling,Vilsmeir reaction, Scholl reaction, Amination reaction, Fries rearrangement, Reversal of FriedelCraft alkylation, Decarboxylation of aromatic acids.

(B) Aromatic Nucleophilic Substitution: SNAr, SN1, benzyne and SRN1 mechanism.Reactivity, effect of substrate structure, leaving group and attacking nucleophile, Von Richter,Sommelet- Hauser, and Smiles rearrangements, Ullman reaction, Ziegler alkylation, Schiemannreaction.

UNIT-II

Common Organic Reactions and Their Mechanisms: Perkin condensation, Michael reaction,Robinson annulation, Diekmann reaction, Stobbe condensation, Mannich reaction, Knoevenagelcondensation, Benzoin condensation, Witting reaction, Hydroboration, Hydrocarboxylation,Ester hydrolysis, Epoxidation.

Reagents in Organic Synthesis: Synthesis and applications of BF3, NBS, Diazomethane, Leadtetra-acetate, Osmium tetraoxide, Woodward Prevorst hydroxylation reagent, LiAlH4, Grignardreagent, organozinc and organolithium reagent.

UNIT-III

Elimination Reactions: Discussion of E1, E2, E1cB and E2C Mechanisms and orientation,Reactivity: Effects of substrate structures, attacking base, leaving group and medium. Ciselimination, elimination in cyclic systems, eclipsing effects, Pyrolytic eliminations, cleavage ofquaternary ammonium hydroxides, Fragmentations: γ-Amino and γ-hydroxy halides,decarboxylation of β-hydroxy carboxlic acid and β-lactones.

UNIT-IV

Pericyclic Reaction: Molecular orbital symmetry, Frontier orbitals of ethylene, 1,3-butadiene,1,3,5 hexatrienes and allyl system. Classification of pericyclic reactions, Woodward-Hoffmanncorrelation diagrams. FMO and PMO approach. Electrocyclic reactions: conrotatory anddisrotatory motions, 4n and 4n+2 and allyl systems. Cycloadditions- antarafacial and suprafacialadditions, 4n and 4n+2 systems, 2+2 addition of ketenes, 1,3 dipolar cycloadditions andchelotropic reactions. Sigmatropic rearrangements-Suprafacial and Antarafacial shifts of H,sigmatropic shifts involving carbon moieties, Claisen, Cope and aza-Cope rearrangements, Enereaction.

Books recommended:1. Advanced Organic Chemistry-Reactions, Mechanism and Structure, Jerry March, John Wiley.2. Advanced Organic Chemistry, F.A. Carey and R.J. Sundberg, Plenum.3. A Guide Book to Mechanism in Organic Chemistry, Peter Sykes, Longman.4. Structure and Mechanism in Organic Chemistry, C.K. Ingold, Cornell University Press.5. Organic Chemistry, R.T. Morrison and R.N. Boyd, Prentice Hall.6. Modern Organic Reactions, H.O. House, Benjamin.7. Principles of Organic Synthesis, R.O.C. Norman and J.M. Coxon, Blackie Academic andProfessional.8. Pericyclic Reactions, S.M. Mukherji, Macmillan, India.9. Reaction Mechanism in Organic Chemistry, S.M. Mukherji and S.P. Singh, Macmillan.10. Stereochemistry of Organic Compounds, D. Nasipuri, New Age International.

(PHYSICAL CHEMISTRY-II)



UNIT – I

Brief resume of law of thermodynamics. Gibb’s and Helmholtz free energy functions and theirsignificance. Partial molal quantities. Partial molal free energy and its variation with temperatureand pressure. Determination of partial molar volume. Thermodynamic criteria for the fugacity ofthe process in terms of entropy change, internal energy change, enthalpy and free energy (Gibb’sand Helmholtz ) change. Gibb’s and Helmholtz equation and its utility in thermodynamics of cellreaction. Thermodynamics of ideal solutions. Fugacity and activity and their variation withtemperature and pressure. Graphical method for the determination of fugacity.

UNIT – II

Chemical potential in case of ideal gases. Chemical equilibrium constant and its temperaturedependence. Law of chemical equilibrium and its application. Clausius and Clapeyron equationand its application for the determination of colligative properties (depression in freezing point,elevation in boiling point and relative lowering of vapour pressure). Determination of molecularweight of non – volatile solutes from colligative properties. Relationship between relativelowering of vapour pressure and osmotic pressure. Van’t Hoff equation for dilute solutions andits application.

Nernst heat theorem and third law of thermodynamics and its application. Thermodynamicderivation of phase rule and its application to two component systems. Distribution law, itsthermodynamic derivation and application. Zeroth law of thermodynamics.

UNIT – III

Non–Equilibrium Thermodynamics: Basic principles of non – equilibrium thermodynamics:rate laws, second law of thermodynamics for open system, law of conservation of mass, chargeand energy. Phenomenological equations for single and coupled flows. Onsager reciprocityrelation. Theorm of minimum entropy production. Curie – Prigogine principle. Applications ofnon – equilibrium thermodynamic: thermoelectricity, electrokinetic phenomena and expressionsfor streaming potential, electro- osmotic pressure difference, streaming potential using the linearphenomenological equations, and to biological membrane system, a qualitative insight.

UNIT –IV

Electrochemistry: Ionic conduction: non–ideal behaviour of electrolytic solutions. Electrolyticalpotential. Derivation of Debye – Huckel Limiting Law. Extended Debye – Huckel Law.Structure of solutions. Detailed treatment of ion–solvent interactions (ion solvation), solvationnumber. Energy conduction. Ion–ion interactions (ion–association). Bjerrum’s theory of ion–association.

Books Recommended:1. Thermodynamics for Chemists: S. Glasstone2. Physical Chemistry: G.M. Barrow3. Non – equilibrium Thermodynamics: C. Kalidas4. Non – equilibrium Thermodynamics: I. Prigogene5. Electrochemistry: S. Glasstone6. Electrochemistry: P.H. Reiger7. Thermodynamics; R.C. Srivastava, S.K. Saha and A.K. Jain8. Modern Electrochemistry Vol. I: J.O’M Bockris and A.K.N. Reddy

(Application of Computer in Chemistry)

Paper: CSA-101 (L:4, T:1, 4.5 credits)Max marks (30+20) Time 3 hours


UNIT-I

Introduction to Computer Systems; Data representation: Number systems, character representationcodes, Binary, hex, octal codes and their inter conversions. Binary arithmetic, Floating point arithmetic,signed and unsigned numbers IEEE standards, CPU organization, ALU, registers, memory, the idea ofprogram execution at micro level. Concept of computing, contemporary Operating Systems such as DOS,Windows, UNIX etc. (only brief user level description). Introduction to organization and architecture ofmainframe, mini and micro systems.

UNIT-II

Concept of flow chart and algorithm; Algorithms to programs: specification, top-down developmentand stepwise refinement ,Introduction to the design and implementation of correct, efficient andmaintainable programs, structured Programming, Use of high level programming Language for thesystematic development of programs, programmability and programming languages, Object codes,compilers. Introduction to the Editing tools such as vi or MS-VC editors.

UNIT-III

C: Data types, Identifiers, Storage class, Constant, Operators, expression, Statements, console I/Ostatements, Selection statements: if-else, switch, Iteration Statements: for, while, do-while, Jumpstatements: return, go to, break, continue, comments. Function, Call by value, Call by reference,arguments to main(), return statements, recursion, function prototypes, reprocessor directives.

UNIT-IV

Single dimensional arrays, two dimensional arrays, multidimensional arrays, variable length arrays.Strings, array of strings. Structures: array of structures, passing structure to function, structure pointers,structure within structures. Unions, bit fields, enumerations. Pointer variables, pointer operator, pointerexpression array of pointers, multiple indirection, pointers to functions, dynamic allocation functions.Recommended Texts:

1. Noggle, J. H. Physical chemistry on a Microcomputer. Little Brown & Co. (1985).2. Venit, S.M. Programming in Basic: Problem solving with structure and style.

Jaico Publishing House: Delhi (1996).3. Engel, T. & Reid, P. Physical Chemistry 2nd Ed. Pearson (2010). Chapter on

Computational Chemistry.

SEMESTER-III(INORGANIC CHEMISTRY-III)



UNIT-I

Metal π Complexes: Preparation, reactions, structures and bonding in carbonyl, nitrosyl,phosphine and related complexes, structural evidences from vibrational spectra, bonding andimportant reactions of metal carbonyls. Structure and bonding in metal cyanides, stabilization ofunusual oxidation states of transition metals.

UNIT-II

Introductory Analytical Chemistry: Data Analysis– Types and sources of errors, propagationof errors, detection and minimization of various types of errors. Accuracy and precision, averageand standard deviation, variance, its analysis and confidence interval, tests of significance (F-test, t-test and paired t-test), criteria for the rejection of analytical data (4d rule, 2.5d rule, Q-test,average deviation and standard deviation), and least-square analysis.Food and Drug Analysis - General methods for proximate and mineral analysis in food(moisture, ash, crude fiber, nitrogen (proteins) and minerals (iron, calcium, potassium, sodiumand phosphorus). Discussion of official (pharmacopea) methods for the determination offollowing drugs as such: (i) Analgin/oxyphenbutazone, (ii) chloramphenicol and related nitrocompounds, (iii) chloroquinine, (iv) phenyl butazone, (v) salicylic acid and (vi) sulphonamides.

UNIT-III

Photoelectron Spectroscopy: Basic principle, photoionization process, ionization energies,Koopman’s theorem, ESCA, photoelectron spectra of simple molecules, (N2, O2 and F2)Photoelectron spectra for the isoelectronic sequence Ne, HF, H2O, NH3 and CH4, chemicalinformation from ESCA, Auger electron spectroscopy – basic idea.

UNIT-IV

Lanthanides and Actinides:- Spectral and magnetic properties, comparison of Inner transition andtransition metals, Trans-uranium elements (formation and colour of ions in aqueous solution),uses of lanthanide compounds as shift reagents, periodicity of trans-lawrencium elements.

Books Recommended:1. Advanced Inorganic Chemistry – Cotton and Wilkinson2. Fundamentals of Analytical Chemistry – Skoog and West3. Quantitative Inorganic Analysis – Vogel4. Chemistry of the Elements – Greenwood and Earnshaw5. Nuclear Chemistry-U.C.Dash6. Nuclear Chemistry – B.G.Harvey7. Nuclear Chemistry – Arnikar8. Techniques in Inorganic Chemistry Vol. II (Nuclear Chemistry-Johnson and Others).9. Modern Aspects of Inorganic Chemistry-H.J.Emeleus and A.G.Sharpe10. Inorganic Chemistry, 4th Edition, - J.E.Huheey, E.A.Keiter and R.L.Keiter.11. Analytical Chemistry-G.D.Christian

(ORGANIC CHEMISTRY-III)

Paper: CHEM -602 (L:4, T:1, 4.5 credits)Max marks (60+40) Time 3 hours


UNIT–1Spectroscopy:

(A) Ultra Violet and Visible Spectroscopy: Electronic transitions (185-800 nm), Beer- LambertLaw, Effect of solvent on electronic transitions, Ultra Violet bands of carbonyl compounds,unsaturated carbonyl compounds, dienes, conjugated polyenes. Fieser-Woodward rules forconjugated dienes and carbonyl compounds, Ultra- Violet spectra of aromatic and heterocycliccompounds. Steric effect in biphenyls. Applications of UV- visible spectroscopy in organicchemistry.

(B) Infrared Spectroscopy: Instrumentation and sample handling, Characteristic vibrationalfrequencies of common organic compounds. Effect of hydrogen bonding and solvent effect onvibrational frequencies, overtones, combination bands and Fermi resonance. Introduction toRaman spectroscopy. Applications of IR and Raman Spectroscopy in organic chemistry.

UNIT-II

Nuclear Magnetic Resonance (NMR) Spectroscopy: General introduction, chemical shift,spin-spin interaction, shielding mechanism, chemical shift values and correlation of protonspresent in different groups in organic compounds. chemical exchange, effect of deuteration,complex spin-spin interaction between two, three, four and five nuclei, virtual coupling.Stereochemistry, hindered rotation, Karplus- relationship of coupling constant with dihedralangle. Simplification of complex spectra-nuclear magnetic double resonance, spin tickling,INDOR, contact shift reagents, solvent effects. Fourier transform technique, Nuclear OverhauserEffect (NOE). Introduction to resonance of other nuclei –F, P, Principle and introduction to C-13NMR, 2-D and 3-D NMR, Applications of NMR in organic chemistry.

UNIT-III

Mass Spectrometry: Introduction, ion production—EI, CI, FD and FAB, factors affectingfragmentation, ion analysis, and ion abundance. Mass spectral fragmentation of organiccompounds, common functional groups, Molecular ion peak, Meta-stable peak, McLaffertyrearrangement. Nitrogen Rule. High-resolution mass spectrometry. Examples of mass spectralfragmentation of organic compounds with respect to their structure determination. Introductionto negative ion Mass spectrometry, TOF-MALDI. Problems based upon IR, UV, NMR and massspectroscopy.

UNIT- IV

Photochemistry – I: Introduction and Basic principles of photochemistry. Interaction ofelectromagnetic radiations with matter. Types of excitations, fate of excited molecules, quantumyield, transfer of excitation energy, actinometry. Photochemistry of alkenes: cis-transisomerization, dimerization of alkenes, photochemistry of conjugated olefins, photo-oxidation ofalkenes and polyenes Photochemistry of Aromatic compounds: Isomerization, addition andsubstitution, photo-reduction of aromatic hydrocarbons

Photochemistry – II: Photochemistry of Carbonyl compounds: Norrish Type I and II,Intermolecular and Intramolecular hydrogen abstraction, Paterno-Buchi reaction, α and β-cleavage reactions of cyclic and acyclic carbonyl compounds, Formation of oxetane andcyclobutane from α, β unsaturated ketones, Photo-reduction of carbonyl compounds, Photo-rearrangement of enones, dienones, epoxyketones, Photo Fries rearrangement.

Books Recommended:1. Practical NMR Spectroscopy, M.L. Martin, J.J. Delpeuch and G.J. Martin, Heyden.2. Spectrometric Identification of Organic Compounds, R. M. Silverstein, G.C.Bassler andT.C.Morrill, John Wiley.3. Introduction to NMR Spectroscopy, R.J. Abraham, J. Fisher and P. Loftus, Wiley.4. Application of Spectroscopy of Organic Compounds, J.R. Dyer, Prentice Hall.5. Spectroscopic Methods in Organic Chemistry, D.H. Williams,I. Fleming, Tata McGraw-Hill.6. Organic spectroscopy by Jagmohan7. Organic spectroscopy by W. Kemp.8. Fundamentals of Photochemistry, K.K.Rohtagi - Mukherji, Wiley-Eastern.9. Essentials of Molecular Photochemistry, A. Gilbert and J.Baggot, Blackwell ScientificPublication.10. Molecular Photochemistry, N.J. Turro, W.A. Benjamin.11. Introductory Photochemistry, A. Cox and T. Camp, McGraw-Hill.12. Photochemistry, R.P. Kundall and A. Gilbert, Thomson Nelson.13. Organic Photochemistry, J. Coxon and B. Halton, Cambridge University Press.14. Organic Photochemistry Vol.I, II, III. Ed. Orville L. Chapman.15. Organic Photochemistry, Ed. Robert O. Kan.

(PHYSICAL CHEMISTRY-III)



Statistical ThermodynamicsUNIT – I

Basic Terminology: probability, phase space, micro and macro states, thermodynamicprobability, statistical weight, assembly, ensemble, probability considerations and chemistry. Themost probable distribution: Maxwell-Boltzmann distribution, Thermodynamic properties fromstatistical Thermodynamics, The Partition Function for monoatomic gas, State functions in termsof partition function, separating partition function: the nuclear and electronic partition function,for molecules, electronic and vibrational partition function,

UNIT – II

Diatomic molecules: Rotations, Polyatomic molecules: Rotations, The partition function of asystem, Thermodynamic properties of molecules from partition function: Total energy, entropy,Helmholtz free energy, pressure, heat content, heat capacity and Gibb’s free energy, equilibriumconstant and partition function, Heat capacity of crystals and statistical thermodynamics,quantum statistics: The Bose- Einstein statistics and Fermi- Dirac Statistics.

UNIT – IIIBasic Quantum Chemistry

Operators in quantum mechanics. Eignvalues and eignfunctions. Hermitian operator and itsapplication. Postulates of quantum mechanics. Angularmomentum of a one – particle system,and its commutative relations. Schreodinger wave equatuion and its formulation as an eignvalueproblem. The uncertainty principle.

Quantum mechanical treatment of translational motion of a particle, particle in one and threedimensional boxes, harmonic – oscillator, rotational motion of a particle: particle on a ring,particle on a sphere, rigid rotator and hydrogen atom. Graphical presentation of orbitals (s, p andd), radial and angular probability distribution plots.

UNIT – IV

Photochemistry: Photophysical processes of electronically excited molecules. Intensitydistribution in the electronic vibrational species. Franck – Condon principle a quantum –mechanical treatment. Excited state dipole moment and acidity constant. Dissociation and pre –dissociation of diatomic molecules. Energy transfer from electronically excited molecules: Stern– Volmer mechanism only. Photophysical pathways: fluorescence, phosphorescence, E type andP- type delayed fluorescence. Kinetic treatment of excimer and exciplex formation.

Books Recommended:1. Physical Chemistry: D.W. Ball2. Theoretical Chemistry by S. Glasston3. Statistical Chemistry by I. Prigogine4. Quantum Chemistry An Introduction: H.L. Strauss5. Introductory Quantum Chemistry: A.K. Chandra6. Quantum Chemistry: A. Mcquarrie7. Quantum Chemistry: I.N. Levine

CHEMISTRY OF LIFE & ENVIROMENTAL



UNIT-I

Cell membrane: Its structure and conformation properties of membranes, active and passivetransport across biomembranes. Muscle contraction and relaxation. Structure and function ofmyoglobin and hemoglobin.

UNIT-II

Environmental Chemistry: Atmosphere, environmental segments, composition of theatmosphere, earth’s radiation balance, particulates, ions and radicals and their formation,chemical and photochemical reactions in the atmosphere, air pollution, oxides of C,N,S and theireffects, acid-rain, smog formation, Green house effects (global warming and ozone depletion, airpollution controls and introduction to analytical methods for monitoring air pollution.

UNIT-III

Hydrosphere: Chemical composition of water bodies-lakes, streams, rivers, sea etc,hydrological cycle, complexation in natural and waste water and microbially mediated redoxreactions. Water pollution-inorganic, organic, pesticides, industrial and radioactive materials, oilspills and oil pollutants, eutrophication, acid-mine drainage, waste water treatment, domesticwaste water (aerobic and anaerobic treatment), and industrial waste water treatment.

UNIT-IV

Water quality parameters and standards: Analytical methods for measuring DO, BOD, COD,fluoride, oils and grease and metals (As, Cd, Hg, Pb, Zn,Cu,Cr), Biochemical effects of As, Cd,Hg, Pb, Cr, CN and pesticides.Lithosphere: Soil composition, micro and macro nutrients, soil pollution-fertilizers, pesticides.

Books Recommend:1. Principles of Biochemistry –A.L.Lehringer2. Introduction to Chemistry of Life-H.J.DeBay3. Outlines of Biochemistry-Conn and Stumpf4. Environmental Chemistry-A.K.De5. Environmental Chemistry-Manaham6. Environmental Pollution Analysis-Khopkar

SEMESTER-IV(BIO-ORGANIC, BIO-INORGANIC AND BIO-PHYSICAL)



UNIT-I

(a) Metalloporphyrins: (ref. Books No. 1,5,): Porphyrins and their salient features,characteristic absorption spectrum of porphyrins, chlorophyll (structure and its role inphotosynthesis). Transport of Iron in microorganisms (sidrophores), types of siderophores(catecholate and Hydroxamato siderophores).

(b) Metalloenzymes: (Ref. Book No. 1,2): Definitions: Apoenzyme, Coenzyme,Metalloenzyme, structure and functions of carbonic anhydrase A & B, carboxy peptidases.

UNIT-II

Oxygen Carriers: (Ref. Book No. 1,8):a) Natural oxygen carriers: Structure of hemoglobin and myoglobin, Bohr effect, Models forcooperative interaction in hemoglobin, oxygen Transport in human body (-perutz machanism),Cyanide poisoning and its remedy. Non-heme protiens (Hemerythrin & Hemocyanin).

b) Synthetic oxygen carriers: Oxygen molecule and its reduction products, model compoundsfor oxygen carrier (Vaska’s Iridium cjomplex, cobalt complexes with dimethyl glyoxime andschiff base ligands).

UNIT-III

Carbohydrates: Types of naturally occurring sugars: Deoxy-sugars, amino sugars, branchedchain sugars. General methods of structure and ring size determination with particular referenceto maltose, lactose, sucrose, pectin, starch and cellulose, photosynthesis of carbohydrates,metabolism of glucose, Glycoside- (amygdalin).

UNIT-IV

Amino acid, peptides and proteins: General methods of peptide synthesis, sequencedetermination.Chemistry of insulin and oxytocin. Purines and nucleic acid. Chemistry of uric acid, adenine,protein synthesis.

Cell membrane and its structure: The Cell Membrane, lipids in biological membranes, typesand arrangements of proteins in membranes, lipo proteins. Danielli and Davson model, FluidMosaic Model, permeability of cell membrane. Bio-Energetics: Thermodynamic Considerations:standard free energy change in bio-chemical reactions, exergonic, endergonic reactions,hydrolysis of ATP and its synthesis from ADP.

Books Recommended:1. The Inorganic Chemistry of Biological processes - M.N.Hughes.2. Bio Inorganic Chemistry - Robert Wittay3. An Introduction to Biochemcial Reaction Mechanism - James N.Lowe and Lloyalt Ingraham.4. Physical Chemistry of Macromolecules: S.F.Sun5. The Enzyme Molecules: W. Ferdinand

SEMESTER-IV (ELECTIVE)(ADVANCED ORGANOMETALLICS)



UNIT-IOrganometallic Compounds of transition elements: Types of ligands and their classificationsin organometallic compounds , 16 and 18 electron rule and its limitations. Hapto-nomenclature,synthesis, structure and bonding aspects of following organometallic compounds with carbon- πdonor ligandsa) Two electron donor (olefin and acetylenic complexes of transition metals)b) Three electron donor (π-allyl complexes of transition metals)c) Four electron donor (butadiene and cyclobutadiene complexes of transition metals)d) Five electron donor (cyclopentadienyl complexes of transition metals – metallocenes withspecial emphasis to ferrocenes)e) Six electron donor [Benzene (arene) complex] Fluxional and dynamic equillibria incompounds such as ƞ2-olefin, ƞ3- allyl and dienyl complexes.

UNIT-II

Homogeneous Transition metal catalysis: General considerations, Reason for selectingtransition metals in catalysis (bonding ability, ligand effects, variability of oxidation state andcoordination number), basic concept of catalysis (molecular activation by coordination andaddition), proximity interaction (insertion/inter-ligand migration and elimination,rearrangement). Phase transfer catalysis. Homogeneous hydrogenation of unsaturatedcompounds (alkenes, alkynes, aldehydes and ketones). Asymmetric hydrogenation.

UNIT-III

Some important homogeneous catalytic reactions:- Ziegler Natta polymerization of ethyleneand propylene, oligomerisation of alkenes by aluminumalkyl, Wackers acetaldehyde synthesis,hydroformylation of unsaturated compounds using cobalt and rhodium complexes, Monsantoacetic acid synthesis, carboxylation reactions of alkenes and alkynes using nickel carbonyl andpalladium complexes. Carbonylation of alkynes (acetylene) using nickel carbonyls or Palladiumcomplexes.

UNIT-IV

Metal-metal bonding in carbonyl and halide clusters:- Polyhedral model of metal clusters,effect of electronic configuration and coordination number, Structures of metal carbonyl clustersof three atoms M3(CO)12 (M=Fe, Ru & Os), Four metal atoms (tetrahedra) [M4(CO)12 {M= Co,Rh & Ir}] and octahedron of type M6(CO)16 [M= Co & Rh], and halide derivatives of Rhenium(III) triangles, metal carbonyls involving bridged-terminal exchange and scrambling of COgroup.

Transition Metal-Carbon multiple bonded compounds:-Metal carbenes and carbines(preparation, reactions, structure and bonding considerations). Biological applications andenvironmental aspects of organometallic compounds, Organometallic compounds in medicine,agriculture and industry.

Books Recommended:1. Principles of organometallic compounds – Powell2. Organometallic chemistry (an Introduction) – Perkin and Pollar3. Organometallic chemistry – Parison4. Advanced Inorganic Chemistry – Cotton and Wilkinson5. Organometallic Chemistry-R.C.Mehrotra6. Organometallic compounds of Transition Metal-Crabtree7. Chemistry of the Elements – Greenwood and Earnshaw8. Inorganic Chemistry – J.E.Huheey9. Homogeneous transition metal catalysis – Christopher Masters10. Homogeneous Catalysis – Parshall11. Principles and Application of HomogeneousCatalysis – Nakamura and Tsutsui12. Progress in Inorganic Chemistry Vol. 15 – Lipard. (Transition metal clusters – R.B.King)13. Organotransition metal chemistry by S.G.Davis, Pergamon press 1982.14. Principles and applications of organotransition metal chemistry by Ccollmen and Hegden

(MEDICINAL CHEMISTRY)



UNIT-IDrug Design: Development of new drugs, procedures followed in drug design, concepts of leadcompound and lead modification, concepts of prodrugs and soft drugs, structure-activityrelationship (SAR), factors affecting bioactivity, resonance, inductive effect, isosterismbioisosterism, spatial considerations. Theories of drug activity: occupancy theory, rate theory,induced fit theory. Quantitative structure activity relationship. History and development ofQSAR. Concepts of drug receptors. Elementary treatment of drug receptor interactions. Physico-Chemical parameters: lipophilicity, partition coefficient, electronic ionization constants, steric,Free-Wilson analysis, Hansch analysis relationships between Free-Wilson and Hansch analysis.

UNIT-II

Pharmacokinetics and Pharmacodynamics: Pharmacokinetics: Introduction to drugabsorption, disposition, elimination using pharmacokinetics. Important pharmacokineticparameters in defining drug disposition and in therapeutics. Mention of uses of pharmacokineticsin drug development process.Pharmacodynamics: Introduction, elementary treatment of enzyme stimulation, enzymeinhibition, sulphonamides, membrane active drugs, drug metabolism, xenobiotics,biotransformation. Significance of drug metabolism in medicinal chemistry.

UNIT-III

Antibiotics and Antiinfective Drugs: Antibiotics: Structure, SAR and biological action ofantibiotics. Examples: penicillin: penicillin G, penicillin V, ampicillin, amoxycillin,chloramphenicol, cephalosporin, tetracycline and streptomycin. Sufonanmides: Structure, SARand mode of action of sulfonamides, sulfonamide inhibition and probable mechanisms ofbacterial resistance to sulfonamides. Examples: sulfodiazine, sulfofurazole, acetyl sulfafurazole,Sulfagnanidine, Phthalylsulfo acetamide, Mafenide. Sulphonamide related compounds Dapsone.Local antiinfective drugs: Introduction and general mode of action. Examples: sulphonamides,furazolidone, nalidixic acid, ciprofloxacin, norfloxacin, chloroquin and primaquin

UNIT-IV

Psychoactive Drugs: Introduction, neurotransmitters, CNS depressants and stimulants. SAR andMode of actions. Central Nervous System Depressant: General anaesthetics. Sedatives &Hypnotics: Barbiturates and Benzodiazepines. Anticonvulsants: Barbiturates, Oxazolidinediones,Succinimides, Phenacemide and Benzodiazepines. Psycotropic Drugs: The neuroleptics(Phenothiazines and butyrophenones), antidepressants (Monoamine oxidases inhibitors andTricyclic antidepressants) and anti-anxiety agents (Benzodiazepines). Central Nervous SystemStimulants: Strychnine, Purines, Phenylethylamine, analeptics, Indole ethylamine derivatives,

Books Recommended:1. An Introduction to Medicinal Chemistry, Graham L. Patrick.2. Medicinal Chemistry: Principles and Practice Edited by F.D. King.3. Textbook of Organic Medicinal and Pharmaceutical Chemistry, Edited by Charles O. Wilson,Ole Gisvold, Robert F. Doerge.4. Introduction to Medicinal Chemistry, Alex Gringuage.5. Principles of Medicinal Chemistry, William O. Foye, Thomas L. Lemice and David A.Williams.6. Introduction to Drug Design, S.S. Pandeya and J. R. Dimmock, New Age International.7. Burger’s Medicinal Chemistry and Drug Discovery, Vol-1 (Chapter-9 and Ch-14), Ed. M.E.Wolff, John Wiley.8. Goodman and Gilman’s Pharmacological Basis of Therapeutics, Mc Graw-Hill.9. The Organic Chemistry of Drug Design and Drug Action, R.B. Silverman, Academic Press.

POLYMER CHEMISTRY



UNIT -I

Polymers: Macromolecular Concepts, Importance of polymers, Chemical and geometricalstructure of polymers, Polymerization: Chain polymerization, step growth polymerization,electrochemical, metathetical polymerization, group transfer polymerization, co-ordination.Concept of copolymerization, copolymer equation, reactivity ratio, Alfrey-price scheme,Polymerization techniques, Kinetics of chain and step growth polymerization.V

UNIT- II

Stereoisomerism in Polymers: Types of stereoisomerism in polymers, Monosubstitutedethylenes ( Site of steric isomerism, Tacticity), Disubstituted ethylenes (1,1-disubstitutedethylenes, 1,2- disubstituted ethylenes), 1,3- Butadiene and 2-Substituted 1,3-Butadienes (1,2-and 3,4- Polymerizations, 1,4-Polymerizations), 1- Substituted and 1,4- Disubstituted 1,3-Butadienes (1,2- and 3,4- Polymerizations, and 1,4- Polymerizations). Stereoregular polymers:Significance of stereoregularity (isotactic, syndiotactic, and atactic polypropenes), Cis- andtrans-1,4-poly-1,3- dienes, Cellulose and amylose. Coordination polymerization: Ziegler Nattacatalyst.

UNIT- III

Polymer Characterization: Average molecular weight concept. Number, weight and viscosityaverage molecular weights. Polydispersity and molecular weight distribution. The practicalsignificance of molecular weight. Measurement of molecular weights. End group, viscosity, lightscattering, osmotic and ultra centrifugation methods. Analysis and testing of polymers- chemicalanalysis, spectroscopic methods, thermal Analysis, XRD and SEM.

UNIT-IV

(A) Commercial Polymers: Polyethylene, Polyvinyl chloride, Polyamides, Polyesters, phenolicresins, epoxy resins and silicone polymers. Functional polymers-Fire retarding polymers andelectrically conducting polymers.

(B) Supramolecular polymer chemistry: Supramolecular polymer chemistry: Generation ofhydrogen bonded supramolecular molecules polymers and liquid crystals, Basic features ofsupramolecular polymers, Supramolecular polymers as supramolecular materials.Supramolecular low molecular weight complexes (Liquid-crystalline complexes and nonliquid –crystallne complexes. Supramolecular side chain polymers (Liquid-crystalline polymericcomplexes and nonliquid -crystallne polymeric complexes). Functionalization of complexes.Nanochemistry: Basic concepts and Applications.

Books Recommended:1. Molecular Mechanics, U. Burkert and N.L. Allinger, ACS Monograph 177, 1982.2. Organic Chemist’s Book of Orbitals. L. Salem and W.L. Jorgensen, Academic press.3. Mechanism and Theory in Organic Chemistry, T.H.Lowry and K.C. Richardson, Harper andRow.4. Introduction to Theoretical Organic Chemistry and Molecular Modeling, W.B. Smith, VCH,Weinheim.5. Physical Organic Chemistry, N.S. Isaacs, ELBS/Longman.6. Supramolecular Chemistry; Concepts and Perspectives, J.M. Lehn, VCH.7. The Physical Basis of Organic Chemistry, H.Maskill, Oxford Univ. Press.8. Textbook of Polymer Science, F.W. Billmeyer Jr. Wiley.9. Polymer Science, V.R. Gowarikar, N.V. Visvanathan and J. Sreedhar, Wiley Eastern.10. Functional Monomers & Polymers, K. Takemoto, Y. Inaki and R.M. Ottanbrite.11. Contemporary Polymer Chemistry, H.R. Alcock and F.W. Lambe, Prentice Hall.12. Physics & Chemistry of Polymers, J.M.G. Cowie, Blakie Academic and Professional.

ADVANCED QUANTUM CHEMISTRY



UNIT - I

Time – independent perturbation theory for non – degenerate states (first order correction toenergy and wave function), and its application to particle in a one – dimensional box, groundstate helium atom (without spin consideration) and perturbed harmonic – oscillator. Variationalmethod: theory and application to ground state hydrogen and helium atoms and one –dimensional oscillator.

UNIT - II

Theory of time – dependent quantum approximation technique. Fermi Golden Rule. Radiation –Matter interaction (induced emission and absorption of radiation). Einstein’s transitionprobabilities. Determination of selection rules in respect of rigid rotation and harmonic –oscillator approximation.

UNIT - III

Quantum – mechanical of multielectron atoms: Hartree self – consistent method. Hartree – Fockself – Consistent (HFSCF) method. Rootham’s method. Correlation energy (CE) andconfiguration interaction (CI). Koopmann’s theorm. Basic idea of Density Functionla Theory(DFT): Kohn – Sham equation.

UNIT –IV

Quantum – mechanical treatment of diatomic molecules: The Born Oppenheimer approximationand its formulation. The valence – bond treatment of a hydrogen molecule. Heitler – Londontreatment and ionic contribution. Molecular Orbital Theory (MOT) of H2

+. MOT withconfiguration interaction (CI). Hybridization (sp, sp2 and sp3) from a quantum – mechnical view– point.

Quantum – mechanical treatment of Π - electron systems. The Π - electron approximation . Freeelectron molecular orbital (FEMO) method and its application to polyenes. The Huckel –Molecular Orbital Theory (HMOT) for conjugated hydrocarbons and cyclic conjugated systems.Huckel calculations for ethylene, allyl systems, cyclobutadiene and benzene. Calculation ofelectron density, charge distribution and bond orders.

Books Recommended:1. Quantum Chemistry An Introduction: H.L. Strauss2. ntroductory Quantum Chemistry: A.K. Chandra3. Quantum Chemistry: D.A. McQuarri4. Quantum Chemistry: I.N. Levine5. Molecular Quantum Mechanics: P.W. Atkins6. Elementary Quantum Chemistry: F.L. Pilar7. Introductory Quantum Chemistry: S.R. LaPaglia8. Fundamental Quantum Chemistry: T.E. Peacock

(SOLID STATE CHEMISTRY)



UNIT - I

X- ray diffraction: Indexing of powder and crystal photographs. Determination of Bravais lattice,point group and space group. Determination of space group with examples. Electron diffraction:The scattering of electron by gases (Wierl equation), visual method, radial distribution methodand applications. Neutron diffraction: Introduction, differences between neutron and X- raydiffraction. Application to structure modification and magnetic compounds.

UNIT - II

Bonding in crystals: Ionic crystals, lattice energy of ionic crystals, metallic crystals. Band theory.Imperfections: Point defects (Schottky and Frankel defects). Thermodynamic derivation of thesedefects. Theories of Bonding: Free electro theory; quantum approach, Fermi – Dirac statistics.Zone theory: quantum approach, allowed energy zones , Brillioun zones, k – space, Fermisurfaces and density states.

UNIT - III

Properties of crystals: Electrical properties of metals; conductors and non – conductors,conductivity in pure metals. Hall effect. Thermal properties: Theories of specific heat. Electricalproperties of semiconductors: Band theory, intrinsic and extrinsic semiconductors. Electrons andholes. Temperature dependence and mobility of charge carriers. Optical properties: Absorptionspectrum, photoconductivity, photovoltaic effect and luminescence. Refraction Birefringenceand color centre. Dielectric properties: Piezoelectricity, Rerro electricity, Ionic conductivity andelectric breakdown.

UNIT – IV

Superconductivity: Experimental survey, occurrence of superconductivity, destruction ofsuperconductivity by magnetic fields (Meissner effect). Thermodynamic effects ofsuperconducting species (entropy, thermal conductivity and energy gap). Quantum tunnling.Theoretical survey (thermodynamics of superconducting transition, London equation, coherencelength). BCS theory of superconductivity.

Solid State Reactions: General principles: experimental procedures, kinetics of solid statereactions, vapour phase transport methods, interaction or ion exchange reaction, electrochemicalreduction methods, preparation of t5his films, growth of single crystal, high pressure andhypothetical method.

Books Recommended:1. Introduction to Solids: Azaroff2. Solid State Chemistry and its applications: West3. Solid State Chemistry: Charkrabarty4. Solid State Chemistry: N.B. Hannay5. Solid State Physics: Kiittal

(CHEMISTRY OF MACROMOLECULES)



UNIT – I

The science of macromolecules, Importance of macromolecules / polymers, basic concepts ofpolymers viz. monomers, repeat units, degree of polymerization, classification of polymers onthe basis of molecular weight and special arrangement viz. linear, branched and networkpolymers. Types of macromolecules (synthesized and natural), polymerization by condensationand addition reactions only. Molecular forces and chemical bonding in simple molecules andmacromolecules and their effects on the physical properties. Polymer solutions, criteria forpolymer solubility, conformations of dissolved polymer chains. Different models for describingthe size and shape of dissolved macromolecules, configuration and conformation ofmacromolecules.

UNIT – II

Thermodynamics of polymer solutions, thermodynamics of simple liquid mixtures, idealsolutions, regular solutions, lattice model of solutions (Flory – Huggins Theory), Flory –Krigbaum theory for dilute polymer solutions. Phase separation in polymer solutions involvingbinary polymer – solvent systems, ternary systems and multi – component systems. Fractionationof polymers by different techniques, theory of swelling of cross – linked / network polymers.

UNIT – III

Rheology and Mechanical Properties of Polymers: Brief introduction to rheology and mechanicalproperties of polymers, phenomena of viscous flow, kinetic theory of ribber elasticity,amorphous polymers and practical importance of their aggregation states, viscoelasticity(experimental and dynamic method), general mechanical models for an amorphous polymer,molecular structure and visco-elasticity. The glassy state and glass transition temperature. Themechanical properties of crystalline polymers.

UNIT – IV

1. Mechanical strength of polymers: Mechanical strength and life time of polymer mechanismof polymer fracture, effect of various factors on the mechanical properties of polymers (effect ofsize and shape, effect of fillers, effect of cross – linked density).

2. Polyelevtrolytes: The water soluble charged polymers and their applications. Ionomers (ioncontaing polymers) conducting polymers solid polymer electrolytes, mechanism of conductivity,polymer colloids and their applications in commercial and industrial formulations (adhesives,coating, paper, pharmaceutical and medical applications), polymer microgels, biomedicalpolymers. Polymers in combating environmental pollution and as chemical reagents.

Books Recommended:1. Text Book of Physical Chemistry: G.M. Barrow2. Text Book of Polymer Chemistry: Billmeyer3. Polymer Chemistry: P.J. Flory4. Physical Chemistry of Polymers: A Tagger5. Physical Chemistry of Macromolecules: C. Tanford6. Introduction to Polymer Science: V.R. Gowarikar, N.V. Vishwanathan and J. Sridhar7. Principles of Polymer Science: P. Bhadur and N.V. Sastry

PRATICALS

(INORGANIC CHEMISTRY PRACTICAL-I)

Paper: CHEM-551 (P:4, T:0, 2 credits)Max marks (30+20) Time 3 hours

1. Volumetric Analysis:(a) Potassium iodate titrations: Determination of iodide, hydrazine, antimony (III) and arsenic(III)

(b) Potassium bromate titrationsi) Determination of antimony (III) and arsenic (III) Direct Method)ii) Determination of aluminium, cobalt and zinc (by oxine method)

(c) EDTA titrationsi) Determination of copper, nickel, magnesiumii) Back titrationiii) Alkalimetric titrationiv) Titration of mixtures using masking and demasking agentsv) Determination of hardness of water

2. Commercial Analysis:i) Determination of available chlorine in bleaching powderii) Determination of Oxygen in hydrogen peroxide.iii) Determination of Phosphoric acid in commercial phosphoric acid.iv) Determination of Boric acid in borax.v) Determination of metals: copper in copper oxychloride and zinc in zineb fungicides.

(ORGANIC CHEMISTRY PRACTICAL-I)

Paper: CHEM -552 (P:4, T:0, 2 credits)Max marks (30+20) Time 3 hours

Qualitative Analysis: Separation, purification and identification of binary mixture of organiccompounds by

i) chemical testsii) TLCiii) Column chromatography andiv) IR spectroscopy.

Books Recommended:1. Experiments and Techniques in Organic Chemistry, D.Pasto, C. Johnson and M.Miller,Prentice Hall.2. Macroscale and Microscale Organic Experiments, K.L. Williamson, D.C.Heath.3. Systematic Qualitative Organic Analysis, H.Middleton, Adward Arnold.4. Handbook of Organic Analysis-Qualitative and Quantitative, H.Clark, Adward Arnold.5. Vogel’s Textbook of Practical Organic Chemistry, A.R. Tatchell, John Wiley.

(PHYSICAL CHEMISTRY PRACTICAL-I)


1. Refractive Index (RI) Measurements: Refractive index (RI) measurements of pure solvents,analysis of mixtures of two miscible solvents, molar and atomic refraction determination,polarizability of liquids.

2. Conductometric Measurements: Determination of cell constant, limiting molar conductanceof simple electrolytes in water, verification of Ostwald, dilution law for week acetic acid.

3. Surface Tension Measurements: Surface tension of pure solvents, analysis of mixtures oftwo miscible solvents, verification of Gibb’s Thomson Rule of surface tension.

4.Partition – Coefficient: Determination of partition – coefficient for I2 between water and CCl4

and for benzoic acid between water and benzene.

Books Recommended:1. Senior Practical Physical Chemistry: B.D. Khosla, V.C. Garg and A. Khosla2. Experimental Physical Chemistry: V. Athawale and P. Mathur.3. Practical Physical Chemistry: B. Vishwanathan and P.S. Raghavan.4. Practical in Physical Chemistry: P.S. Sindhu

PRACTICALS(INORGANIC CHEMISTRY PRACTICAL-II)

Paper: CHEM -554 (P:4, T:0, 2 credits)


1. Analysis of mixtures by gravimetric and volumetric methods from the mixture solutions:i. Copper- Nickelii. Copper -Magnesiumiii. Copper-Zinciv. Iron-Magnesiumv. Silver-Zincvi. Copper-Nickel-Zincvii. Fe(II)-Fe(III)

2. Green methods of Preparation of the following:(i) Bis(acetylacetonato)copper(II)(ii) Tris(acetylacetonato)iron(III)(iii) Tris(acetylacetonato)manganese(III)(iv) trisethylenediaminenickel(II)chloride(v) Potassiumdiaquooxalatochromate(III)(vi) Vanadyl acetonate ie oxy-bis-(acetylacetonato) Vanadium (IV)

Books Recommended:1. A text Book of Quantitative Inorganic Analysis: A.I.Vogal.2. Applied Analytical Chemistry: Vermani.3. Commercial Methods of Analysis: Shell & Biffen

(ORGANIC CHEMISTRY PRACTICAL-II)


Organic Synthesis: Acetylation: - Acetylation of cholesterol and separation of cholesterylacetate by column chromatography. Oxidation: Adipic acid by chromic acid oxidation ofcyclohexanol.Grignard reaction: Synthesis of triphenyl methanol from benzoic acid. Aldol condensation:Dibenzal acetone from benzaldehyde. Sandmeyer reaction: p-chlorotoluene from p-toluidine.Acetoacetic ester condensation: Synthesis of ethyl-n-butylacetoacetate by A.E.E condensation.Preparation of iodoform from acetone (Haloform reaction). Preparation of polystyrene,anthranilic acid, fluorosceine-eosin, and methyl orange


(PHYSICAL CHEMISTRY PRACTICAL-II)


1. Adsorption Measurements: Verification of Freundlich adsorption isotherm for I2, acetic acidand oxalic acid on charcoal.

2. Colloidal Solution: Preparation of sol solution of arsenic sulphide and estimation offlocculation value for NaCl, KCl, BaCl2, AlCl3.

3. Thermochemistry: Determination of water equivalent of thermos flask, and estimation ofheat of neutralization for strong acid strong base, weak acid strong base or vice – versa, heat ofhydration and solution of salts.

4. Kinetic Measurement: Kinetics of Hydrolysis of methylacetate and ethylacetate in thepresence of HCl.


(PHYSICAL CHEMISTRY PRACTICAL-II)

Paper: CSA-151 (P:2, T:0, 1 credits)Max marks (30+20) Time 3 hours

Progrmming in C and C++

SEMESTER III(ORGANIC CHEMISTRY PRACTICAL-III)


A. Quantitative Analysis: Determination of the percentage/ number of hydroxyl groups in anorganic compound by acetylation method. Estimation of amines/ phenols using bromate –bromide solution/ acetylation method. Determination of iodine and sponification values of an oilsample. Determination of DO, COD and BOD of water sample.

B. Multistep Synthesis: Cannizzaro reaction: 4-chlorobenzaldehyde as substrate. Benzilic AcidRearrangement: Benzaldehyde à Benzoinà Benzilà Benzilic acid. Hofmann bromamideRearrangement: Phthalic anhydride-à Phthalimideà Anthranilic acid Beckmann Rearrangement:Benzeneà Benzophenone-à Benzophenone oximeàBenzanilide. Skraup Synthesis: Preparation ofquinoline from aniline. Synthesis using Phase Transfer Catalysis: Alkylation of diethyl malonateor ethyl acetoacetate and an alkyl halide.


SEMESTER III(PHYSICAL CHEMISTRY PRACTICAL-III)

Paper: CHEM 652 (P:4, T:0, 2 credits)Max marks (30+20) Time 3 hours

1. Solubility Measurements: Heat of solution of electrolytes by solubility measurements.

2. Heat of transfer Measurements: Heat of transfer for benzoic acid between benzene andwater and I2 between CCl4 and water.

3. Conductometric Measurements: Precipitation titration (AgNO3 – KCl), acid – baseneutralization titration, determination of relative strength of acids in the given mixtures,solubility of sparingly soluble salt.

4. Construction of Phase Diagram: Phase diagram for liquids, (benzene and methanol, ----) andphase diagram for solids, (benzoic acid and cinnamic acid, benzoic acid and naphthalene andacetamide and salicylic acid).

5. Colorimetric Measurements: Verification of Beer – Lambert’s law for aqueous solutions ofKMnO4, K2Cr2O7 and CuSO4 and construction of calibration plot to estimate the unknownconcentration.

6. Kinetic Measurement: Saponification of ethylacetate by NaOH solution.

SEMESTER III(INORGANIC CHEMISTRY PRACTICAL-III)

Paper: CHEM -653 (P:4, T:0, 2 credits)Max marks 30+20 Time 3 hours

501. Analysis of the given sample (Ores)/Both Qualitative and Quantitative Dolomite, Pyrolusite,Galena.

2. Analysis of the given alloys: Coin, Gunmetal, Brass and Bronze.

3. To prepare a pure and dry sample of the following compounds:1. Potassium tris(oxalato)aluminate(III)2. Sodium hexa(nitro)cobaltate(III)3. Potassium tris(oxalato)cobaltate(III)4. Hexa(ammine)cobalt (III)chloride5. Tetrapyridine copper(II)persulphate6. Dinitrotetrapyridine nickel(II)7. Lead tetraacetate

8. Mercury (tetraisothiocyanato)cobaltate(II).and characterize them by the following techniques:

i) Elemental analysisii) Molar conductance valuesiii) I.R. Spectral interpretationiv) Thermal analysisv) UV-Visible Spectra

Books Recommended:1. A Text Book of Qualitative Inorganic Analysis – A.I. Vogel

SEMESTER-IV

CHEMISTRY PRACTICAL FOR (BIO-ORGANIC, BIO-INORGANIC AND BIO-PHYSICAL lab)


(A) Extraction of Organic Compounds from Natural Sources: Isolation of Caffeine from teaLeaves, casein from milk (the students are required to try some typical color reactions ofproteins), lactose from milk (purity of sugar should be checked by TLC and PC and Rf valuereported). lycopene from tomatoes and β- carotene from carrots.

(B) Paper Chromatography: Separation and identification of the sugars present in the givenmixture of glucose, fructose and sucrose by paper chromatography and determination of Rfvalues.

(C) Spectroscopy:Identification of some organic compounds by the analysis of their spectral data (UV, IR, PMR,CMR and MS)Multistep SynthesisSynthesis of VacorSynthesis of IndigoSynthesis of p- nitro aniline

SEMESTER - IVCHEMISTRY PRACTICAL FOR ELECTIVE

Paper: CHEM -655 (P:4, T:0, 2 credits)Max marks 30+20 Time 3 hours

Preparation of the following compounds and a study of the important properties viz. Molarconductance, magnetic sussceptibility, electronic and infrared spectra.

1. Stannic iodide

2. Bis(acetylacetonate) oxovanadium (IV)

3. Tris (acetylacetonate) siliconchloride.

4. Mercuration of phenol.

5. Hexa ammine nickel (II) chloride.

6. Pyridine perchromate.

INSTRUMENTAL ANALYSIS:

(A) Conductometric Titrations:

i) Differential behaviour of acetic acid to determine the relative acid strength of various acidsand basic strength of various bases.

ii) Strong acid-strong base titration in acetic acid.

B) Potentiometric Titrations.1. Neutralisation reactions: i) Sodium hydroxide-hydrolchloric acid.

ii) Sodium hydroxide-Boric acid

iii) Acetic acid and hydrochloric acid-sodium hydroxide.

2. Oxidation-Reduction Reactions.

i) Ferrous-dichromate

ii) Ferrous-Ceric

iii) Iodine-Thiosulphate

3. Precipitation Reactions:

i) Silver nitrate-sodium halides.

4. Complexation Reactions

i) Potassium cyanide-silver nitrate.

C) Colorimetric Analysis:

1) Verification of Beer’s law for KMNO4, K2Cr2O7 solutions and determination of the conc. ofKMNO4 and K2Cr2O7 in the given solution.

2) Colorimetric determination of Iron (III) with potassium thiocyanate reagent or o-Phenanthroline method.

3) Determination of traces of manganese (in steel samples) colorometrically by oxidation topermanganic acid with potassium periodate.

4) Spectrophotometric determination of pK value of an indicator (acid dissociation constt. ofmethyl red)

(D) pH metric –titrations

1) Copper and cactechol

2) Copper and salicylic acid

3) Acid base titrations

4) Mixtures of acids with a base


Date post:	03-Jan-2017
Category:	Documents
Upload:	lamnhi
View:	305 times
Download:	11 times

Download Detailed Syllabus

Documents