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Drug delivery systems: realistic or optimistic attitudes
Seyedmohammad MotevalliProf. Nie
Spring 2016
Drug Delivery SystemDDS defined as a formulation or a device that enables the introduction of a therapeutic substance in the body and improves its efficacy and safety by controlling the rate, time and place of release of drugs in the body.
Jain 2008
Cancer Cells
Kreso and Dick 2014
The Tumor Microenvironment
Thakor and Gambhir 2013
The primary goals for research of Nano-biotechnology in drug delivery include:
More specific drug targeting and delivery Reduction in toxicity while maintaining therapeutic
effects Greater safety and biocompatibility Faster development of new safe medicines
Passive DDS
Targeted drug delivery
Targeted Drug
Delivery Systems
Increased treatment efficacy
Increased specific
localization
Decreased toxic side
effects
Reduced dosage
Controlled bio
distributions
Modulated pharmaco-kinetics
Improved patient
compliance
Peer 2007 Rani 2014 Bae 2011 Philip 2010 Tiwari 2012 Kudgus 2014 Khan 2013
Patents and Articles publication
www.Lexinnova.com
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www.Lexinnova.com
Nanoparticles Evolution
Zhang 2013
Examples of FDA approved DDS in the market
-Continued
Zhang 2013
Examples of nanoparticles used in cancer therapy and their current stage
-continued
Thakor 2013
Nanoparticles Type
Silica Metal Semoconductor
composite
Glass/Quartz Carbon Polyme
r
Drug molecules and Targeting ligands
Cagdas 2014
Copolymers
Bonacucina 2011 www.Wikipedia.org
Stimuli Responses Nanoparticles
Endogenous responses
pH-responsive
Enzyme concentratio
n
Redox gradients
Exogenous responses
Temperature
Magnetic field
Ultrasound intensity
Light Chen 2016
Endogenous responses
Mura 2013 Plank 2009 Chen 2016
Exogenous responses
Mura 2013 Meng 2016 Jacob 2014
Late 1970’s Current Era Future
First Nanoscale drug delivery system was lipid vesicles.
Nowadays, liposomes, cream, capsule, tablets, gel, aqueous solution, aerosols/spray are used as forms of delivery.
Nano enabled technology will take the maximum share of the market making up nearly 90% of drug delivery market.
Considered impossible to administer the pharmaceuticals suspensions by intravenous means, due to obvious risks of embolism.
15% of market uses nanoparticle for drug delivery systems.
Safe, Effective and without side effects. No wastage and increased bioavailability are going to be the basis of future drug delivery.
First paper was published in 1976; it focused on development of nanoparticle for vaccine purposes.
More specific for treatment. More-energetic and more-targeted methods, in which medications ride passively on the circulating bloodstream, where they may ormay not arrive at micro cracks in a high enough dosage to initiate healing.
References
Bae, Y. H. and K. Park (2011). "Targeted drug delivery to tumors: myths, reality and possibility." Journal of Controlled Release 153(3): 198.
Bonacucina, G., et al. (2011). "Thermosensitive self-assembling block copolymers as drug delivery systems." Polymers 3(2): 779-811.
Çağdaş, M., et al. (2014). Liposomes as Potential Drug Carrier Systems for Drug Delivery, INTECH. Chen, Y.-C., et al. (2016). "Non-metallic nanomaterials in cancer theranostics: a review of silica-and
carbon-based drug delivery systems." Science and Technology of Advanced Materials. Jain, K. K. (2008). "Drug delivery systems-an overview." Drug delivery systems: 1-50. Khan, I. U., et al. (2013). "Microfluidics: a focus on improved cancer targeted drug delivery
systems." Journal of Controlled Release 172(3): 1065-1074. Kreso, A. and J. E. Dick (2014). "Evolution of the cancer stem cell model." Cell stem cell 14(3): 275-
291. Kudgus, R. A., et al. (2014). "Tuning pharmacokinetics and biodistribution of a targeted drug
delivery system through incorporation of a passive targeting component." Scientific reports 4.
Meng, Z., et al. (2016). "NIR‐Laser‐Switched In Vivo Smart Nanocapsules for Synergic Photothermal and Chemotherapy of Tumors." Advanced Materials 28(2): 245-253.
Mura, S., et al. (2013). "Stimuli-responsive nanocarriers for drug delivery." Nature materials 12(11): 991-1003. Peer, D., et al. (2007). "Nanocarriers as an emerging platform for cancer therapy." Nature nanotechnology
2(12): 751-760. Philip, A. K. and B. Philip (2010). "Colon targeted drug delivery systems: a review on primary and novel
approaches." Oman Med J 25(2): 79-87. Plank, C. (2009). "Nanomedicine: silence the target." Nature nanotechnology 4(9): 544-545. Rani, K. and S. Paliwal (2014). "A review on targeted durg delivery: its entire focus on advanced therapeutics
and diagnostics." Sch. J. App. Med. Sci 2(1C): 328-331. Thakor, A. S. and S. S. Gambhir (2013). "Nanooncology: the future of cancer diagnosis and therapy." CA: a
cancer journal for clinicians 63(6): 395-418. Tiwari, G., et al. (2012). "Drug delivery systems: An updated review." International journal of pharmaceutical
investigation 2(1): 2. Zhang, Y., et al. (2013). "Advanced materials and processing for drug delivery: the past and the future."
Advanced drug delivery reviews 65(1): 104-120.
References
Thank you for your kindly attention