DtiStudio

Susumu MoriJohns Hopkins University

Overall direction of DTI research

DWIs

Smaller b (<1,200), fewer directions (<30), 2mm, 5 min

Larger b (> 3,000), more directions (>60), lower resolution, longer time

Tensor calculation

High Angular-Resolution Diffusion Imaging

Overall direction of DTI research

DWIs

Smaller b (<1,200), fewer directions (<30), 2mm, 5 min

Tensor calculation

Overall direction of DTI research

DWIs

Smaller b (<1,200), fewer directions (<30), 2mm, 5 min

Tensor calculation

• Automated and quantitative quality control pipeline• Fully automated cloud-based web-based pipeline• Integration of image quantification schemes• Dynamic programming for fiber tracking• Automated fiber tracking

DtiStudio

How DTI studies could go wrong

Motion

Eddy-current distortion

Outlier pixels (dropout, ghost)

Registration

Slice rejectionPixel rejection

Motion monitoringEddy current monitoring

Motion monitoring

Non-physiological motion

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XMR-SNR-test-AH: dtRegVoltranslationy

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XMR-SNR-test-AH: cumulateddtrotationmetric

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Eddy current monitoring

Importance of tensor fitting quality

Images that CAN’T be registered

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Outlier rejection

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Original image

After registrationArtifact masked

Select subject to show results

Population report Matlab code

MriStudio Pipeline

DWIs

DtiStudio

DiffeoMapRoiEditor

254 structures

Example of multi-modal analysis

Automated pipelineRead DICOM data

Tensor calculation QC report

Scalar map calculation Save images

Skull-strip

Linear registration

Atlas-based parcellation

Save images

Save tables

Database solution

Initiate image analysis pipeline

Specify the data for analysis

Calculation startsResults become available

Fiber tracking: path-generation

Automated parcellation of the brain

Fiber tracking: path-generation

Overall direction of DTI research

DWIs

Smaller b (<1,200), fewer directions (<30), 2mm, 5 min

Tensor calculation

• Automated and quantitative quality control pipeline• Fully automated cloud-based web-based pipeline• Integration of image quantification schemes• Dynamic programming for fiber tracking• Automated fiber tracking

Acknowledgment• Program development

– Hangyi Jiang– Xin Li

• Server implementation– Anthony Kolasny– Can Ceritoglu– Bill Schneider

• Quantification module– Michael Miller– Yue Li– Xiaoying Tang

• Atlas generation– Kenichi Oishi– Anderia Faria