PhD in Integrated Biology and Medicine
Information brochure on the curriculum
requirements for each of our 5
signature research programs
2011 IBM Program Cancer & Stem Cell Biology (CSCB)
Cancer affects one in three people during their lifetime and is a leading cause of death worldwide. Our rapidly growing CSCB program takes both basic and clinical-translational approaches to understand key signaling pathways of cancer and highlight innovation in developing and advancing cancer therapeutics.
Our groups are conducting world-class science in many different fields in cancer research including stem cell research to fight against cancer. Our program benefits from close interactions with collaborative networks with the existing cancer research community in Singapore, including the National Cancer Center (NCC), Singapore General Hospital, NUS, and the A*STAR Research Institutes.
Curriculum Requirement: 60 modular credits (MC)
40 MC from research at the mentors laboratory (3.5 yrs), 6 MC from two rotations, 4 MC from IBM core course (1st year), and 4 MC from CDN5101 Fundamentals of Cancer Biology Course, 6MC
from other courses (your mentor and you will decide together).
IBM mentors list at CSCB
* Please look at details of research projects and publications by faculty members in the following website. Some faculty have links to their additional laboratory websites. http://www.duke-nus.edu.sg/web/research/signature-research-programs/cancer-stem-cell-biology
NAME RESEARCH TOPIC LAB EMAIL TEL
David M. VIRSHUP (Prof., Program Director)
Cancer Biology, Signal Transduction, protein phosphorylation, Wnt signaling
Patrick J CASEY (Prof., Senior Vice-Dean for Research)
G protein signal transduction impacting cancer cell proliferation and metastasis
Alexandra PIETERSEN ( Asst. Prof.)
Mammary stem cells and breast cancer, mouse models, flow cytometry
Caroline LEE (Assoc. Prof.)
Functional Genomics of Hepatocellular Carcinoma, Pharmacogenetics/genomics, Population Genetics, Polymorphisms
Kanaga SABAPATHY (Assoc. Prof.)
Pathways regulating carcinogenesis and chemo-sensitivity (c-Jun/JNK and p53/p73), mouse models for cancer and cancer therapeutic agents
Koji ITAHANA ( Asst. Prof.)
ARFMdm2p53 tumor suppressor pathway, apoptosis, cancer metabolism, targeting mitochondria for cancer therapy
Mathijs VOORHOEVE ( Asst. Prof.)
Cancer Biology, tumor suppressors in the p53 pathway, oncogenic microRNAs, ultra-conserved noncoding RNAs
Mei WANG ( Asst. Prof.)
Cancer Biology, experimental cancer therapeutics, protein prenylation and its impact on signaling, autophagy and cell death pathways
Patrick TAN (Assoc. Prof.)
Stomach cancer, cancer genomics, translational medicine
Sang Hyun LEE ( Asst. Prof.)
Cancer Biology, Mitotic checkpoint, chromosomal instability, aneuploidy, anti-mitotic therapy
Shang LI ( Asst. Prof.)
Telomerase regulation, cancer and aging Duke-NUS
Shazib PERVAIZ (Prof.)
Cell death and survival signaling. Redox regulation of cell fate, Bcl2 family and mitochondrial physiology, drug discovery
Sin Tiong ONG (Assoc. Prof.)
Therapeutic targeting of cancer stem cells, mechanisms of drug resistance, haematologic malignancies
2011 IBM Program Emerging Infectious Diseases (EID)
Infections contribute importantly to the overall disease burden and mortality worldwide. The Signature Research Program in Emerging Infectious Diseases integrates the surveillance of new and emerging pathogens with the development of new treatment, prevention, and control strategies. Our program closely interfaces with diverse academic, government, and industry partners on the national and international level, and it is rapidly establishing itself as a leader in the infectious diseases research community in South East Asia. Researchers in our program investigate different aspects of dengue and other arboviruses, influenza, and Rickettsia biology, ranging from epidemiological surveys in humans and animals, mechanistic studies of entry, replication and egress, immune response to infection, to drug and vaccine development and efficacy assessment, thus providing opportunities for research projects with basic and translational research and public health focus. Students can work with any of the mentors listed below.
Curriculum Requirement: 60 modular credits (MC) 40 MC from research at the mentors laboratory (3.5 yrs), 6 MC from two rotations, 4 MC from IBM core course (1st year), and 4 MC from GMS 6904 Principles of Infectious Diseases Course, 2 MC from GMS 6905 Developments in Infectious Diseases, and 4MC from other courses (your mentor and you will decide together).
Mentor list at EID
* Please look at details of research projects and publications by faculty members in the following website. Some faculties have links to their additional laboratory websites.
NAME RESEARCH TOPIC LAB EMAIL TEL
Duane Gubler (Professor, ProgramDirector)
Dengue and other vector-borne disease epidemiology, surveillance, prevention and control; Pathogen discovery
Ooi Eng Eong (Associate Professor)
Pathogenesis of dengue; the interactions of dengue immune complexes with monocytes
Subhash Vasudevan (Associate Professor)
Viral therapeutics, drug discovery, pathogenesis mechanism studies for dengue and other vector-borne viruses.
Veronika von Messling (Associate Professor)
Pathogenesis of respiratory viruses, host response assessment, animal models
Gavin J Smith (Associate Professor)
Ecology, evolution, population dynamics, molecular epidemiology, interspecies transmission of emerging infectious diseases
Manoj Krishnan (Assistant Professor)
Cell biology of viral infection; antiviral innate immune mechanisms
Lok Shee Mei (Assistant Professor)
Structural changes of dengue virus during infection.
Specialty Track in Cardiovascular and Metabolic Disorders PhD Program in Integrated Biology and Medicine, Duke-NUS
About the Program
The increased prevalence of cardiovascular and metabolic disorders (e.g. hypertension, atherosclerosis, heart failure, diabetes, etc.) poses an enormous risk for the inhabitants of Singapore and the world. With an aging and increasingly sedentary population, the unabated rise in these diseases is unlikely to slow in the near future, and their treatment accounts for a disproportionate percentage of health care costs. To combat this burgeoning epidemic, Duke-NUS launched a signature research program in Cardiovascular and Metabolic Disorders (CVMD) that will train graduate students in this important discipline. The CVMD program houses state-of-the-art research capabilities, including core facilities for profiling mitochondrial function (e.g. oxygen consumption, ATP production, etc.) and metabolic adaptations (e.g. indirect calorimetry, euglycemic clamps, etc.) in human patients and other model organisms. Moreover, its new Metabolomics Facility allows one to obtain both targeted and non-targeted profiles of nutrient metabolites (e.g. fatty acids, amino acids, citric acid cycle intermediates, etc.) using mass spectroscopy. Application of these technologies allows one to gain a strong appreciation of the metabolic dysregulation that serves as an underpinning for cardiovascular and metabolic diseases. As part of the training regimen, CVMD students will conduct independent research under the tutelage of one of our world-class research scientists. Moreover, they will take advanced coursework on molecular cardiovascular biology and integrated metabolism. Students trained in this program will be on a path to become independent investigators running independent research programs in industry or academia.
IBM Mentors in CVMD
Shirish SHENOLIKAR, Professor Protein phosphatases; transduction of signals by metabolic and environmental stress
Shigeki SUGII, Assistant Professor Adipose stem and iPS cells; fat metabolism; diabetes; nuclear receptors; regenerative therapeutics
Scott A. SUMMERS, Associate Professor Lipid metabolism and lipotoxicity; diabetes
Paul M. YEN, Associate Professor Thyroid function; nuclear hormone receptor; hepatic steatosis; PI