CANCER DISCOVERY
February 2021 CANCER DISCOVERY
EDITORIAL OFFICE: Cancer Discovery [ISSN 2159-8274 (Print); ISSN 2159-8290 (Online)] is published monthly, one volume per year, by the American Association for Cancer Research, Inc., 615 Chestnut Street, 17th Floor, Philadelphia, PA 19106-4404. Periodicals postage paid at Philadelphia, PA, and additional mailing offices. POSTMASTER: Send address changes to Cancer Discovery, AACR Member Services, 615 Chestnut Street, 17th Floor, Philadelphia, PA 19106-4404 or E-mail: [email protected]. Copyright 2021 by the American Association for Cancer Research, Inc. The paper used in this publication meets the requirements of ANSI/NISO Z39.48-1992 (Permanence of Paper).
Robert T. Abraham
Ash A. Alizadeh
James P. Allison
Carlos L. Arteaga
Alan Ashworth
Alberto Bardelli
David Barrett
Himisha Beltran
René Bernards
Elizabeth H. Blackburn
John Blenis
Paolo Boffetta
Joan S. Brugge
John C. Byrd
Andrea Califano
Hannah Carter
Arul Chinnaiyan
Heather R. Christofk
Karen Cichowski
Ryan B. Corcoran
Sara A. Courtneidge
Lisa Coussens
Christina Curtis
Alan D. D’Andrea
Ralph J. DeBerardinis
Johann S. de Bono
David G. DeNardo
Ronald A. DePinho
Maximilian Diehn
Susan M. Domchek
Olivier Elemento
Matthew J. Ellis
Jeffrey A. Engelman
Douglas T. Fearon
Howard A. Fine
Silvia C. Formenti
Lori Friedman
Stephen Frye
Dmitry I. Gabrilovich
Jennifer R. Grandis
Nathanael S. Gray
Daniel A. Haber
William C. Hahn
Kevin M. Haigis
Douglas Hanahan
Matthew D. Hellmann
Helen E. Heslop
Manuel Hidalgo
Patrick Hwu
David M. Hyman
Tyler Jacks
Elizabeth M. Jaffee
William G. Kaelin
Alec C. Kimmelman
Theodore S. Lawrence
Jonathan D. Licht
Christine M. Lovly
Douglas R. Lowy
Ravindra Majeti
Tak W. Mak
Sami N. Malek
Richard M. Marais
Elaine R. Mardis
John M. Maris
Joan Massagué
Frank McCormick
Ignacio Melero
Ingo K. Mellinghoff
Ari M. Melnick
Gordon B. Mills
Sean J. Morrison
Yael Mosse
Benjamin G. Neel
Olufunmilayo I. Olopade
Pier Paolo Pandolfi
William Pao
Nickolas Papadopoulos
D. Williams Parsons
David R. Piwnica-Worms
Helen M. Piwnica-Worms
Kornelia Polyak
Carol Prives
Antoni Ribas
Jeremy N. Rich
Charles W.M. Roberts
Jeffrey M. Rosen
Mark A. Rubin
Yardena Samuels
Charles L. Sawyers
Alice T. Shaw
Margaret A. Shipp
Kevan M. Shokat
M. Celeste Simon
Lillian L. Siu
Mark J. Smyth
David B. Solit
Jean-Charles Soria
Laura Soucek
Kimberly Stegmaier
Charles Swanton
Josep Tabernero
Craig B. Thompson
Nicholas C. Turner
David A. Tuveson
Robert H. Vonderheide
Karen H. Vousden
Jennifer A. Wargo
Ashani T. Weeraratna
Kathryn E. Wellen
E. John Wherry
Eileen White
Monte M. Winslow
Timothy A. Yap
scientific editors
Luis A. Diaz
editoriAL stAff
SENIOR EXECUTIVE EDITOR
Robert Kruger
EXECUTIVE EDITOR
Elizabeth S. McKenna
SENIOR EDITORS
Michele M. Hartsough
I-Mei Siu
ASSOCIATE EDITOR
Avital Lev
SENIOR EDITOR, SCIENCE AND MEDICAL NEwS
Suzanne L. Rose
wRITER/REPORTER, SCIENCE AND MEDICAL NEwS
Catherine C. Caruso
SCIENCE wRITER
Nicole Haloupek
SENIOR EDITORIAL ASSOCIATE
Ingrid Lin
SENIOR PRODUCTION PROjECT EDITOR
Julie Ehlers
Lewis C. Cantley
editors-in-chief
CANCER DISCOVERYISSN 2159-8274 (pRINt) ≠ ISSN 2159-8290 (ONLINE)
publishing information
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SCOPECancer Discovery publishes high-impact, peer-reviewed articles describing major advances in research and clinical trials. As the premier cancer information resource, the Journal also presents Review Articles,
AACR OFFICERSAntoni Ribas, PresidentDavid A. Tuveson, President-ElectElaine R. Mardis, Past PresidentWilliam N. Hait, TreasurerMargaret Foti, Chief Executive Officer
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Per spectives and Commentaries, News stories, and Research Watch summa-ries of important journal articles to its readers to keep them informed about the latest findings in the field. Topics span the spectrum of cancer research and medicine from the laboratory to the clinic and epidemiologic studies.
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