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Introduction
• Phototherapy - mainstay of treatment
unconj. Hyperbili.
• PT is effective in reducing excessive
unconj. Hyperbili.
• drastically curtailed the use of ET
• Phototherapy should be regarded as a
drug, with an appropriate dose and
duration
PT – Indication
• The initiation and duration of PT decided by
- total bilirubin values
- an infant’s postnatal age
- the potential risk for bilirubin neurotoxicity
Efficacy of PT Devices
Depends on -
• Spectral qualities of the light source used (wavelength range and peak)
• Intensity of the light (irradiance)
• Body surface area exposed by the irradiated field or “footprint.”
• Distance between the light and the infant’s skin
Advances in Neonatal Care • Vol. 11, No. 5S, 2011
Optimal Administration of PT –
Practical Considerations
• Light source (wavelength) (nm)
• Light irradiance (W·cm2·nm1)
• Body surface area (cm2)
• Continuity of therapy
• Efficacy of intervention
• Duration of therapy
Practice Considerations - Light source (nm)
• Recommendation - Wavelength spectrum in
460- 490-nm blue-green light region
• Imp. - Know the spectral output of the light
source
Pediatrics 2011;128;e1046
Light source /Wavelength
• visible white light spectrum - 350 to 800 nm
• Bilirubin absorbs visible light most strongly
in the blue region of the spectrum (~460 nm)
• the most effective light in vivo is probably
in the blue-to-green region (460–490 nm).
Light source /Wavelength
Commercial Light Sources
• Fluorescent
- cool white daylight
- blue [B]
- special blue [BB]
- Turquoise and green
• narrow-band special blue bulbs
- TL52/20W [Phillips] or
- F20T12/BB [GE]
- More effective
Light source /Wavelength
• Special blue (BB) fluorescent lights
- not be confused with white lights painted
blue or covered with blue plastic sheaths
• Unless specified otherwise, plastic covers
or optical filters need to be used to remove
potentially harmful UV light.
Light source /Wavelength
• commercial compact fluorescent-tube
light (CFL) sources
• LEDs of narrow spectral bandwidth
- used as over- and under-the-body
devices.
• Fiberoptic - pads, blankets
• Halogen - spotlights
Light source /Wavelength
• High intensity gallium nitride LEDs with
emission within the 460- to 490-nm regions
are as effective as CFL / Conventional
- lower heat output,
- low infrared emission, and
- no ultraviolet emission
- a longer lifetime (20 000 hours)Adv Biomed Res. 2012; 1: 51.
Light Irradiance (intensity )
• Light intensity or energy output is defined by irradiance
• number of photons (spectral energy) that are delivered per unit area (cm2) of exposed skin
• The dose of phototherapy - measure of the irradiance delivered for a specific duration and
adjusted to the exposed body surface area (µW·cm2·nm)
Light Irradiance
• Recommendation : Use optimal irradiance
• The recommended minimal irradiance levels
are 8– 12 µW⁄cm2 ⁄nm
• for intensive PT ≥30 W·cm2·nm within the
460- to 490-nm waveband
• Imp: Ensure uniformity over the light footprint
area
Pediatrics 2011;128;e1046
Light Irradiance
• Devices that emit lower irradiance may be supplemented with auxiliary devices
• bringing the light source close to the infant increases irradiance
- Caution : not be done with halogen lights
The ideal distance and orientation of the light source should be maintained according to the manufacturer’s recommendations
• The irradiance of all lamps decreases with use
Practice Considerations –
Body surface area (cm2)
• Recommendation : Expose maximal skin area
• Imp : Reduce blocking of light
Pediatrics 2011;128;e1046
Body Surface Area
• Complete (100%) exposure of the total body
surface to light is impractical and limited by use
of eye masks and diapers
• Circumferential illumination achieves exposure of
approximately 80% of the total body surface.
• In clinical practice, exposure is usually planar
(ventral or dorsal)
• Approximately 35% of the total body surface is
exposed with either method
Body Surface Area
• Changing the infant’s posture every 2 to 3 hrs
-maximizes the area exposed to light
• Exposed body surface area treated rather than
the number of devices (double, triple, etc)
used clinically more important
• Physical obstruction of light by equipment
decreases the exposed skin surface area
Pediatrics 2011;128;e1046
Body Surface Area
• Combining several devices, will increase the
surface area exposed.
- placing a light source beneath the infant
• reflecting material around the incubator or
radiant warmer bed useful
Pediatrics 2011;128;e1046
Practice Considerations
• Continuity of therapy as far as possible
• Recommendation : Briefly interrupt for
feeding, parental bonding, nursing care
• Imp : After confirmation of adequate
bilirubin concentration decrease
Pediatrics 2011;128;e1046
Practice Considerations
• Efficacy of intervention
• Recommendation : Periodically measure
rate of response in bilirubin load reduction
• Imp : to look at , Degree of total serum
bilirubin concentration decrease
Pediatrics 2011;128;e1046
Efficacy of intervention
- Rate of Response
• The clinical response depends on
the rates of bilirubin production
enterohepatic circulation
bilirubin elimination
the degree of tissue bilirubin deposition
the rates of the photochemical reactions of
bilirubin.
Efficacy of intervention
- Rate of Response
• The clinical impact of phototherapy should
be evident within 4 to 6 hours
• Decrease of more than 2 mg/dL in serum
bilirubin concentration.
• Periodicity of serial measurements is based
on clinical judgment.
Optimal Administration of PT
• Practice Considerations - Duration of therapy
• Recommendation : Discontinue at desired
bilirubin threshold, be aware of possible
rebound increase
• Imp : Serial bilirubin measurements based on
rate of decrease
Pediatrics 2011;128;e1046
Failure of PT
• an inability to observe a decline in bilirubin of
1-2 mg/dL after 4-6 hours and/or
• to keep the bilirubin below the BET level.
• ? Consider intensive PT
• No Role of prophylactic PT in preterm babies
NNFguidelines2010
Stopping Phototherapy
• serum bilirubin level has fallen below 2mgs/dL
lower than threshold
• Check for rebound
Consider if prematurity, direct Coombs test
positivity, and those treated < 72 hours.
Not indicated if, non-hemolytic etiology and an
early follow up after discharge
NNFguidelines2010
Phototherapy Infants ≤ 35 weeks GA
• Generally used in a prophylactic mode
• goal - to prevent further elevation TSB
• at least in infants with BW<750 g, initiate
phototherapy at lower irradiance levels
• increase irradiance levels, or increase the
surface area of the infant exposed to PT,
if the TSB continues to rise
MJ Maisels et al , 2012
Measuring Light Irradiance
• Visual estimations of brightness & use
of ordinary photometric/colorimetric
light meters are inappropriate
• measured with a radiometer (W·cm2)
or spectroradiometer (W·cm2·nm1)
over a given wavelength band.
Measuring Light Irradiance
• Irradiance should be measured at several
sites on the infant’s body surface
• different radiometers may show different
values for the same light source
• Use manufacturer recommended
Measuring Light Irradiance
• For improving the application of effective phototherapy, need to develop an affordable, user-friendly, handheld, universal irradiance meter which accurately measures irradiance delivered by all types of phototherapy light sources.
Vreman HJ, Indian Pediatr, 2010
Safety And Protective Measures
• Four decades of neonatal phototherapy use
- no serious adverse clinical effects
• Ensure adequate hydration, nutrition, and
temperature control.
• Devices - Must meet electrical and fire hazard
safety standards (IEC )
Safety And Protective Measures
• Eye patches - Purulent eye discharge and
conjunctivitis in term infants with prolonged
use
• Use of diapers: Diapers may be used for
hygiene but are not essential.
• PT Contraindication
- infants with congenital porphyria or those
treated with photosensitizing drugs.
PT- Sunlight
• Sunlight will lower the serum bilirubin level,
the practical difficulties involved in safely
exposing a naked newborn to the sun either
inside or outside (and avoiding sunburn)
preclude the use of sunlight as a reliable
therapeutic tool.
Key Messages 1
• Use special blue tubes or LED light source with output in blue-green spectrum
• If special blue fluorescent tubes are used, bring tubes as close to infant as possible to increase irradiance
• For intensive PT, expose maximum surface area of infant to PT.
• Place lights above and fiber-optic pad or special blue fluorescent tubes* below the infant.
Key Messages 2
• Intensive PT requires >30 μW/cm2 per nm.
• For maximum exposure, line sides of bassinet, warmer bed, or incubator with aluminum foil.
• Use intensive PT for higher TSB levels.
• Periodically measure rate of response
• Monitor Irradiance