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Elizabeth M. Whitley, DVM, PhD, Dipl. ACVP1
Isabel Hurtado Rodriguez, DVM, MS, Dipl. ACVIM2
Amelia S. Munsterman, DVM, MS, Dipl. ACVS2
1Department of Pathobiology2Department of Clinical SciencesCollege of Veterinary MedicineAuburn University
www.sogonow.com/archives/2007/01/07-week/
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
5-year-old, male castrated, American quarter horse
Used for roping Recent, intermittent reluctance to work
on the right handRecent, unexplained weight loss
www.sogonow.com/archives/2007/01/07-week/
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Presented for colic that was non-responsive to Banamine and sedation
Clinical signs: Dehydration, tachycardia, tachypnea Copious nasogastric reflux when tubed Distended small intestine on ultrasound
and palpation Diagnosed a renal mass on ultrasound
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Rare neoplasm in animals other than pigs or chickens
Usually observed in young animals
“Wilms’ tumor” in children
http://www.nlm.nih.gov/medlineplus/ency/imagepages/9056.htm
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Three different morphologies Blastemal (undifferentiated, embryonic)
cells Epithelial cells Mesenchymal cells
Benign or malignant
en.wikibooks.org/.../Pregnancy_and_birth
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Vimentin Desmin
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Smooth muscle actin
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Cytokeratin
Cytokeratin
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Basement membrane
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Malignant nephroblastoma, triphasic, kidney, with metastasis to liver, spleen, and mesentery.
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Inactivation of the Wilms’ tumor gene (WT1) WT1 protein is a transcription factor that
functions as a tumor suppressor gene▪ Is expressed during renal and gonadal
development Defects in WT1 gene prevents normal
differentiation of metanephric stem cells Other genetic defects identified in
children with Wilms’ tumor ( including WT2, WT3, WT4)
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Thanks to Dr. Eva Sartin, Beth Landreth, Uschi Wolfert for technical assistance in histopathology.
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only