Emerging TechnologiesSemantic Web and Data Integration

This meeting will start at 5 min past the hourAs a reminder, please place your phone on mute unless you are speaking

18 Oct 2013

Meeting Agenda

• Representing CDISC Standards in RDF - Update• Team CDISC Conformance Checks in RDF – Update• Team Protocol Representation in RDF – Update• PhUSE Conference Brussels• AOB

Representing CDISC Standards in RDF

Representing CDISC Standards in RDF

Deliverables: • CDASH v1.1 including domain assumptions• SDTM v1.2/SDTM v3.1.2 including domain assumptions• SDTM v1.3/SDTM v3.1.3 including domain assumptions• SEND IG v3.0 including domain assumptions• ADaM v2.1/ADaM IG v1.0• Integrate with Controlled Terminology

Deliverables

Schema Structure

Meta-Model Schema

Controlled Terminology Schema

CDISC Schema

CDASH Schema SDTM Schema SEND Schema ADaM Schema

CDASH SDTM SEND ADaM

SDTM Walk-Through

SDTM Walk-Through

SDTM Walk-Through

SDTM Walk-Through

SDTM Walk-Through

SDTM Walk-Through

Finishing Line

• Update a few remaining namespaces for consistency• Final check of the CDISC schema• Final check of the domain assumptions• Consistent formatting of the import files• Dirty work

– typo’s, trailing blanks, non-ASCII characters etc.• Code repository

– github.com/phuse-org/rdf.cdisc.org

GitHub Repository

Next Steps

• Call for review of draft models• Discuss ownership process with CDISC• Discuss SHARE export facility to RDF• Alignment and final edit

• Representing CDISC Conformance Checks in RDF– Scott Bahlavooni and Josephine Gough

• Protocol Representation in RDF– Geoff Low and Frederik Malfait

New Teams Starting…

• Representing and Accessing Clinical Trial Data in RDF– Tentative: Phil Ashworth and Marc Andersen

• Data Analysis and Reporting Model– To be explored

• Representing Regulations and Guidance in RDF – Status to be discussed

• EHR Enabled Research– To be explored

Pipeline

Representing Conformance Checks in RDFBackup Slides

• Represent SDTM and ADaM validation rules in RDF• Implementation algorithms will not be represented

Objective

• ADaM standard includes validation rules• Identifying all validation rules associated with an SDTM

(ADaM) domain or variable is a non-trivial, manual task• Vendor-agnostic representation of SDTM validation

rules

Rationale

• Define an ontology for validation rules• Identify version(s) of SDTM/ADaM validation rules for

representation• Link the RDF representations to CDISC standards

represented in RDF

Deliverables

Protocol Representation in RDF

Tasks

• Represent Schedule of Assessments in RDF• Represent Trial Design in RDF• Represent the PRM in RDF

Challenges

• PRM primarily BRIDG based, unlike CDASH/SDTM• End of Year, deadlines

Approach

• Read and understand– Study Design Model (XML)– Protocol Representation Model (PRM)

• Identify key components– Classes– Properties

• Model using XLSX and TopBraid

Approach (cont.)

• Consultation– Dave Gemzik (head of PRG)

• Expectations– ~ 1hr + 1hr

• Communication– PhUSE Wiki– Email– Team meetings

PhUSE Conference Brussels

What happened

• More people talking about RDF and Linked Data• Presentation Semantic Technology and CDISC Standards• PhUSE CSS Discussion Club