ENDOCRINE AND METABOLIC RESPONSE

TO

TRAUMA

STIMULI

PNS and CNS

RESPONSE

STIMULI

1.BLOOD VOLUME 2.O2 ,CO2 ,H+3.PAIN4.EMOTIONAL(FEAR & STRESS)5.WOUND

RESPONSE

LOCAL RESPONSE SYTEMIC RESPONSE

TISSUE INJ. NUERO-ENDOCRINE

METABOLIC

LOCAL INJ.

Macrophage or Monocytelysozyme,pg,IL-1,IL-2,TNF,Interferon

NutrophilLeukotriene B4,elastase,acid hydrolaselysozyme,PGE2

Mast cellHistamine,protease,heparin,ECF,PGD2leukotrienes C4,TNF

METABOLIC

GLUCOSE

FAT

PROTEIN

FLUID-ELECTROLYTE