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Epithelial pathology
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CASE 1
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HISTOPATHOLOGY
B-Bulbous rete ridges 10 X-H&E
B-Moderate dysplasia 10X-H&E
A-Break in the continuity of basement membrane-10X-H&E
A-Hyperorthokeratinised epithelium10X-H&E
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DIAGNOSIS
SQUAMOUS CELL CARCINOMA IN ASSOCIATION WITH VERRUCOUS LEUKOPLAKIA
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CASE 2
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HISTOPATHOLOGY
B-Para keratin plugging- 10x-H&E
A-Sub epithelial inflammatory infiltrate and features of mild dysplasia-40x-H&E
A-Hyperplastic epithelium- 4x-H&Ewww.rxdentistry.blogspot.com
DIAGNOSIS
VERRUCOUS CARCINOMA IN ASSOCIATION WITH ORAL SUBMUCOUS FIBROSIS
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CASE 3
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Sheets of malignant epithelial cells arranged within thin connective tissue septa-4x-H&E
Cellular and Nuclear pleomorphism 40 X-H&E
HISTOPATHOLOGY
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Vascular invasion - 40 X-H&E
HISTOPATHOLOGY
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Nuclear pleomorphism with mitotic figure- 40X-H&E
Area of necrosis 40X-H&E
HISTOPATHOLOGY
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DIAGNOSIS
SINONASAL UNDIFFERENTIATED CARCINOMA
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CASE 4
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HISTOPATHOLOGY
Epithelial plugging 10x-H&E
Broad pushing margins into the connective tissue-10x-H&E
Surface epithelium showing plugging-10x-H&E
Parakeratinised stratified squamous epithelium with dysplasia-10x-
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DIAGNOSIS
VERRUCOUS CARCINOMA. (CARCINOMA CUNICULATUM)
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CASE 5
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Sheets of spindle cells adjacent to an area of malignant epithelial cells. 10X-H&E
HISTOPATHOLOGY
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Section shows pleomorphic epithelial cells along with spindle cells-40X-H&E
HISTOPATHOLOGY
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Immunohistochemical stain, cytokeratin, epithelial cells, spindle areas
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DIAGNOSIS
SPINDLE CELL SQUAMOUS CARCINOMA
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CASE 6
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Malignant epithelial island in connective tissue-10x-H&E
Dysplastic islands showing hyperchromatism-10X-H&E
HISTOPATHOLOGY
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HISTOPATHOLOGY
Section shows numerous malignant cells with features of pleomorphism and mitotic figures-40x-H&E
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DIAGNOSIS
MODERATELY DIFFERENTIATED SQUAMOUS CELL CARCINOMA
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CASE 7
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Island of dysplastic cells within the connective tissue-10x-H&E
Sheets of malignant epithelial cells-
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HISTOPATHOLOGY
Section shows sheets of pleomorphic malignant cells-40x-H&E
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DIAGNOSISPOORLY DIFFERENTIATED SQUAMOUS CELL
CARCINOMA
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CASE 8
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Acantholysis within malignant islands 10x-H&E
Lobular growth pattern 10x-H&E
Malignant epithelial islands and keratin pearls 10x-H&E
Dysplastic epithelium and break in continuity of basement membrane10x-H&E
HISTOPATHOLOGY
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DIAGNOSIS
ADENOID SQUAMOUS CELL CARCINOMA –Variant of Squamous cell carcinoma.
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CASE 9
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HISTOPATHOLOGY
Photomicrograph shows atypical melanocytes in the basilar layer of overlying epithelium and spindle as well as round cells in the connective tissue (H&E), 10x.
Photomicrograph shows the junctional proliferation at the epithelial–connective tissue interface along with few epitheloid cells in the connective tissue (H&E), 40x.
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Focal positivity for S100
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DIAGNOSIS
DESMOPLASTIC MALIGNANT MELANOMA
Published as “Desmoplastic malignant melanoma of alveolus – A rare entity", in Oral Oncology EXTRA (2006) 42, 291– 294
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THANK YOU
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