Cover illustration: Evolution of transcriptional regulatory networks in prokaryotes. See the articleby Madan Babu et al. in this issue.

Escherichia coli

Bordetella pertussis

Haemophilus influenzae

Staphylococcus aureus

Mycobacterium tuberculosis

Cover illustration: Evolution of transcriptional regulatory networks in prokaryotes. See the articleby Madan Babu et al. in this issue.

Escherichia coli

Bordetella pertussis

Haemophilus influenzae

Staphylococcus aureus

Mycobacterium tuberculosis

Crp

NarL

Lrp

Fnr

Ihf

PhoB

FruR

PurR

Fur

Cover illustration: Evolution of transcriptional regulatory networks in prokaryotes. See the articleby Madan Babu et al. in this issue.

Escherichia coli

Cover illustration: Evolution of transcriptional regulatory networks in prokaryotes. See the articleby Madan Babu et al. in this issue.

Bacillus anthracis Streptomyces coelicolor

Escherichia coli

Cover illustration: Evolution of transcriptional regulatory networks in prokaryotes. See the articleby Madan Babu et al. in this issue.

TranscriptionFactor

Target gene

Cover illustration: Evolution of transcriptional regulatory networks at multiple levels of organization. See the article by Madan Babu et al. in this issue.

Cover illustration: Matrix representation of the conservation of transcriptional regulatory interactions across175 prokaryotes. See the article by Madan Babu et al. in this issue.

TranscriptionFactor

Target gene