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Esophageal Strictures
William Stanford – Leader & BSACDaniel Frost – BWIG
Thomas Fleming – Communicator
Client:Dr. Mark Reichelderfer, MD
Advisor:Professor John Webster
Presentation Outline
•Problem Statement
•Background Information
•Current Methods
•Design Constraints
•Possible Designs
•Future Work
Background Information•Esophageal Stricture
•Stomach acid reflux into esophagus forms stricture•Also from cancer, lung problems, and genetics•Causes heartburn
•Treatment•Surgery and dilation
•Surgery is complicated and risky•Dilation is more safe
•Inflatable balloon inside the esophagus
Background Information
•Stricture Size and Compliance
•Compliance = Volume/Pressure
•Little work has been done involving compliance
•Compliance gives information about scar tissue
•Can lead to better treatment options
•Potential correlation between stricture types
Problem Statement
Device should:
•Measure pressure in balloon
•Measure change in volume of syringe
•Graph volume/pressure curve in real time
•Be aesthetically pleasing for hospital setting
•Eventually be commercially available
Design Constraints
•Work with current dilation procedure
•Provide real time data
•Provide warning of esophageal perforation
•Software that runs on hospital computers
•Compliance accurate to three significant figures
•Compact enough for hospital setting
•Safety
Current Prototype•Syringe is filled with saline
•Pressure measured with pressure transducer
•Volume measured with linear potentiometer
•Outputs are connected to an amplifier circuit
•Circuit connects to computer
Design 1: LabViewAdvantages:
•Real time graphing•Reads two inputs•Automatically converts units•Simple inputs•Image oriented programming
Disadvantages:•Complicated•Time consuming to learn•Relatively expensive
Design 2: BioBench
Advantages:•No programming required•Has a playback mode•Multiple inputs•Less expensive
Disadvantages:•No real time graphing•No automatic unit conversion•Data has to be exported in Microsoft Excel
Design 3: PascoAdvantages:•Real time graphing•Data can be entered into equations•Easy to use•Two inputs•Least expensive
Disadvantages:•No support for saline pressure sensor
Design MatrixWeight (out of 100)
LabView BioBench Pasco
Graphing Capability
70 70 10 60
Ease of Use 5 2 3 4
Inputs 10 9 9 0
Unit Conversion
10 8 1 6
Cost 5 1 2 5
Total 100 90 25 75
Future Work
•Write software program for graphing
•Develop amplification circuit
•Testing
•Aesthetic finalization
•Gain IRB approval
•Human testing
References
•http://sine.ni.com/nips/cds/view/p/lang/en/nid/1454
•http://en.wikipedia.org/wiki/Image:Labview-logo.png
•http://www.pasco.com
•Hale, A. et. al. (2002). Barostat to Measure Esophageal Strictures.
•Kirking, H. et. al. (2002). Barostat to Measure Esophageal Strictures.
•Seashore, K. et. al. (2006). Device for Dilating Esophageal Strictures.