Essential Medicines WHO 15th edition

8/6/2019 EssentialMedicines WHO15thedition

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EssentialMedicines15thedition(March2007)WHO Model List (revised March 2007)

EML 15, page - 1

WHOModelList(revisedMarch2007)

ExplanatoryNotes

Thecorelistpresentsalistofminimummedicineneedsforabasichealthcaresystem,listingthe

mostefficacious,safeandcosteffectivemedicinesforpriorityconditions.Priorityconditionsare

selectedonthebasisofcurrentandestimatedfuturepublichealthrelevance,andpotentialforsafe

andcosteffectivetreatment.

Thecomplementarylistpresentsessentialmedicinesforprioritydiseases,forwhichspecialized

diagnosticormonitoringfacilities,and/orspecialistmedicalcare,and/orspecialisttrainingare

needed.Incaseofdoubtmedicinesmayalsobelistedascomplementaryonthebasisofconsistent

highercostsorlessattractivecosteffectivenessinavarietyofsettings.

Thesquareboxsymbol()isprimarilyintendedtoindicatesimilarclinicalperformancewithina

pharmacologicalclass.Thelistedmedicineshouldbetheexampleoftheclassforwhichthereisthe

bestevidenceforeffectivenessandsafety.Insomecases,thismaybethefirstmedicinethatis

licensedformarketing;inotherinstances,subsequentlylicensedcompoundsmaybesaferormore

effective.Wherethereisnodifferenceintermsofefficacyandsafetydata,thelistedmedicine

shouldbetheonethatisgenerallyavailableatthelowestprice,basedoninternationaldrugprice

informationsources.

Therapeuticequivalenceisonlyindicatedonthebasisofreviewsofefficacyandsafetyandwhen

consistent

with

WHO

clinical

guidelines.

National

lists

should

not

use

a

similar

symbol

and

should

bespecificintheirfinalselection,whichwoulddependonlocalavailabilityandprice.Medicines

arelistedinalphabeticalorder,withinsections.

ThepresenceofanentryontheEssentialMedicinesListcarriesnoassuranceastopharmaceutical

quality.Itistheresponsibilityofeachlocalregulatoryauthoritytoensurethateachbrandisof

appropriatepharmaceuticalquality(includingstability)andthat,whenrelevant,differentbrands

areinterchangeable.

Entriesofthetypeoralliquidareintendedtopermitanysolution,suspensionorotherformof

liquid.Granulesforreconstitutionasanoralliquidmaysubstitutefororalliquids,andtypically

carrybenefitsintheformofbetterstabilityandlowertransportcosts.Ifmorethanonetypeoforal

liquidisavailableonthesamemarket(e.g.solution,suspension,granulesforreconstitution),they

maybeinterchangedandinsuchcasesshouldbebioequivalent.Itispreferablethatoralliquidsdo

notcontainsugarandsolutionsforchildrendonotcontainalcohol.

Entriesofthetypetabletareintendedtoallowvariousformsofimmediatereleasetabletsuchas

uncoated,filmcoated,crushable,chewable,dispersibleetc.Entericcoating,ontheotherhand,

modifiesdrugrelease,andentericcoatedproductsareamodifiedreleasedosageform.Crushable,

chewableanddispersibletabletsmaybeeasiertoadministertopaediatricpopulationsandtothe

elderly.


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EML 15, page - 2

1. ANAESTHETICS

1.1 General anaesthetics and oxygen

halothane Inhalation.

ketamine Injection:50mg(ashydrochloride)/mlin10mlvial.

nitrousoxide Inhalation.

oxygen Inhalation(medicinalgas).

thiopental Powderforinjection:0.5g;1.0g(sodiumsalt)inampoule.

1.2 Local anaesthetics

bupivacaine

Injection:0.25%;0.5%(hydrochloride)invial.

Injection

for

spinal

anaesthesia:

0.5%

(hydrochloride)

in

4mlampouletobemixedwith7.5%glucosesolution.

lidocaine

Injection:1%;2%(hydrochloride)invial.

Injectionforspinalanaesthesia:5%(hydrochloride)in

2mlampouletobemixedwith7.5%glucosesolution.

Topicalforms:24%(hydrochloride).

lidocaine+epinephrine(adrenaline)Dentalcartridge:2%(hydrochloride)+epinephrine1:80000.

Injection:1%;2%(hydrochloride)+epinephrine1:200000invial.

ComplementaryList

ephedrineInjection:30mg(hydrochloride)/mlin1mlampoule

(Foruseinspinalanaesthesiaduringdelivery,topreventhypotension).

1.3 Preoperative medication and sedation for short-term procedures atropine Injection:1mg(sulfate)in1mlampoule.

diazepamInjection:5mg/mlin2mlampoule.

Tablet:5mg.

morphine Injection:10mg(sulfateorhydrochloride)in1mlampoule.

promethazine Oralliquid:5mg(hydrochloride)/5ml.

2. ANALGESICS, ANTI PY RETICS, NON-STEROIDAL ANTI-INFLAMMATORY

MEDICINES (NSAIMs), MEDICINES USED TO TREAT GOUT AND DISEASEMODIFYI NG AGENTS IN RHEUMATOID DISORDERS (DMARDs)2.1 Non-opioids and non-steroidal anti-inflammatory medicines (NSAIMs) acetylsalicylicacid

Tablet:100500mg.

Suppository:50150mg.

ibuprofen Tablet:200mg;400mg.


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EML 15, page - 3

paracetamol*

Tablet:100500mg.

Suppository:100mg.

Oralliquid:125mg/5ml.

*Notrecommendedforantiinflammatoryuseduetolackof

provenbenefittothateffect.

2.2 Opioid analgesics

codeine Tablet:30mg(phosphate).

morphine

Injection:10mg(morphinehydrochlorideormorphinesulfate)

in1mlampoule.

Tablet:10mg(morphinesulfate).

Tablet(prolongedrelease):10mg;30mg;60mg(morphine

sulfate).

Oralliquid:10mg(morphinehydrochlorideormorphine

sulfate)/5ml.

2.3 Medicines used to treat gout

allopurinol Tablet:100mg.

2.4 Disease modifying agents used in rheumatoid disorders (DMARDs)

chloroquine Tablet:100mg;150mg(asphosphateorsulfate).

ComplementaryList

azathioprine Tablet:50mg.

methotrexate Tablet:2.5mg(assodiumsalt).

penicillamine Capsuleortablet:250mg.

sulfasalazine Tablet:500mg.

3. ANTIALLERGICS AND MEDICINES USED IN ANAPHYLAXISchlorphenamine

Injection:10mg(hydrogenmaleate)in1mlampoule.

Tablet:4mg(hydrogenmaleate).

dexamethasoneInjection:4mgdexamethasonephosphate(asdisodiumsalt)in

1mlampoule.

epinephrine(adrenaline)Injection:1mg(ashydrochlorideorhydrogentartrate)in

1mlampoule.

hydrocortisone Powderforinjection:100mg(assodiumsuccinate)invial.

prednisolone*

Tablet:5mg;25mg

*Thereisnoevidenceforcompleteclinicalsimilaritybetween

prednisoloneanddexamethasoneathighdoses.


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EML 15, page - 4

4. ANTIDOTES AND OTHER SUBSTANCES USED IN P OISONINGS

4.1 Non-specific

charcoal,activated Powder.

4.2 Specific

acetylcysteine Injection:200mg/mlin10mlampoule.

atropine Injection:1mg(sulfate)in1mlampoule.

calciumgluconate Injection:100mg/mlin10mlampoule.

deferoxamine Powderforinjection:500mg(mesilate)invial.

dimercaprol Injectioninoil:50mg/mlin2mlampoule.

DLmethionine Tablet:250mg.

methylthioniniumchloride(methylene

blue)Injection:10mg/mlin10mlampoule.

naloxone Injection:400micrograms(hydrochloride)in1mlampoule.

penicillamine Capsuleortablet:250mg.

potassiumferrichexacyanoferrate(II)

2H20(Prussianblue)Powderfororaladministration.

sodiumcalciumedetate Injection:200mg/mlin5mlampoule.

sodiumnitrite Injection:30mg/mlin10mlampoule.

sodiumthiosulfate Injection:250mg/mlin50mlampoule.

5. ANTICONVULSANTS/ ANTIEP ILEPTICS

carbamazepine

Tablet(chewable):100mg;200mg.

Tablet(scored):100mg;200mg.


diazepam Injection:5mg/mlin2mlampoule(intravenousorrectal).

magnesiumsulfate*

Injection:500mg/mlin2mlampoule;500mg/mlin

10

ml

ampoule.

*Foruseineclampsiaandseverepreeclampsiaandnotforother

convulsantdisorders.

phenobarbital

Injection:200mg/ml(phenobarbitalsodium).

Tablet:15100mg(phenobarbital).

Oralliquid:15mg/5ml(phenobarbital)or5ml(phenobarbital

sodium).


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EML 15, page - 5

phenytoin

Injection:50mg/mlin5mlvial(sodiumsalt).

Capsule:25mg;50mg;100mg(sodiumsalt).

Tablet:25mg;50mg;100mg(sodiumsalt).

Tablet(chewable):50mg.

Oralliquid:25 30mg/5ml.*

*Thepresenceofboth25mg/5mland30mg/5mlstrengthson

thesamemarketwouldcauseconfusioninprescribingand

dispensingandshouldbeavoided.

valproicacid

Tablet(crushable):100mg.

Tablet(entericcoated):200mg;500mg(sodiumvalproate).


ComplementaryList

ethosuximideCapsule:250mg.


6. ANTI-INFECTIVE MEDICINES6.1 Anthelminth ics6 .1 .1 I n tes t i na l an the lm in t h i cs albendazole Tablet(chewable):400mg.

levamisole

Tablet:

50

mg;

150

mg

(as

hydrochloride).

mebendazole Tablet(chewable):100mg;500mg.

niclosamide*Tablet(chewable):500mg.

*Niclosamideislistedforusewhenpraziquanteltreatmentfails.

praziquantel Tablet:150mg;600mg.

pyrantelTablet(chewable):250mg(asembonate).

Oralliquid:50mg(asembonate)/ml.

6.1 .2 Ant i f i la r ia ls

ivermectin Tablet(scored):3mg;6mg.

ComplementaryList

diethylcarbamazine Tablet:50mg;100mg(dihydrogencitrate).

suraminsodium Powderforinjection:1ginvial.

6 .1 .3 An t i sch i s tosoma ls and an t i t r ema tode m ed icine

praziquantel Tablet:600mg.

triclabendazole Tablet:250mg.


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EML 15, page - 6

ComplementaryList

oxamniquine*

Capsule:250mg.


*Oxamniquineislistedforusewhenpraziquanteltreatmentfails.

6.2 Antibacterials

6.2 .1 Beta Lactam m ed ic ines

amoxicillinCapsuleortablet:250mg;500mg(anhydrous).

Powderfororalliquid:125mg(anhydrous)/5ml.

amoxicillin+clavulanicacid Tablet:500mg+125mg.

ampicillin Powderforinjection:500mg;1g(assodiumsalt)invial.

benzathinebenzylpenicillin Powderforinjection:1.44gbenzylpenicillin(=2.4millionIU)in

5mlvial.

benzylpenicillinPowderforinjection:600mg(=1millionIU);3g(=5millionIU)

(sodiumorpotassiumsalt)invial.

cefazolin*Powderforinjection:1g(assodiumsalt)invial.

*Forsurgicalprophylaxis.

cefixime*

Capsule:400mg.

*Onlylistedforsingledosetreatmentofuncomplicatedano

genital

gonorrhoea.

cloxacillin

Powderforinjection:500mg(assodiumsalt)invial.

Capsule:500mg;1g(assodiumsalt).

Powderfororalliquid:125mg(assodiumsalt)/5ml.

phenoxymethylpenicillinPowderfororalliquid:250mg(aspotassiumsalt)/5ml.

Tablet:250mg(aspotassiumsalt).

procainebenzylpenicillinPowderforinjection:1g(=1millionIU);3g(=3millionIU)in

vial.

ComplementaryList

ceftazidime Powderforinjection:250mg(aspentahydrate)invial.

ceftriaxone Powderforinjection:250mg,1g(assodiumsalt)invial.

imipenem*+cilastatin*

Powderforinjection:250mg(asmonohydrate)+250mg(assodium

salt);500mg(asmonohydrate)+500mg(assodiumsalt)invial.

*Onlylistedforthetreatmentoflifethreateninghospitalbased

infectionduetosuspectedorprovenmultidrugresistantinfection.


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EML 15, page - 7

6.2 .2 Other an t ibacte r ia ls

azithromycin*

Capsule:250mgor500mg.


*OnlylistedforsingledosetreatmentofgenitalC.trachomatis

andoftrachoma.

chloramphenicol

Capsule:250mg.

Oilysuspensionforinjection:0.5g(assodiumsuccinate)/mlin

2mlampoule.

Oralliquid:150mg(aspalmitate)/5ml.

Powderforinjection:1g(sodiumsuccinate)invial.

ciprofloxacin*Tablet:250mg(ashydrochloride).

*Finalselectiondependsonindicationforuse.

doxycycline*Capsuleortablet:100mg(hydrochloride).


erythromycin

Capsuleortablet:250mg(asstearateorethylsuccinate).

Powderforinjection:500mg(aslactobionate)invial.

Powderfororalliquid:125mg(asstearateorethylsuccinate).

gentamicin*Injection:10mg;40mg(assulfate)/mlin2mlvial.


metronidazole

Injection:500mgin100mlvial.

Tablet:200500mg.

Suppository:500mg;1g.

Oralliquid:200mg(asbenzoate)/5ml.

nitrofurantoin Tablet:100mg.

spectinomycin Powderforinjection:2g(ashydrochloride)invial.

sulfamethoxazole+trimethoprim

Injection:80mg+16mg/mlin5mland10mlampoules.

Tablet:100mg+20mg;400mg+80mg.

Oralliquid:200mg+40mg/5ml.

trimethoprim Tablet:100mg;200mg.

ComplementaryList

clindamycinInjection:150mg(asphosphate)/ml.

Capsule:150mg.

sulfadiazine Injection:250mg(sodiumsalt)in4mlampoule.

Tablet:500mg.


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EML 15, page - 8

vancomycin Powderforinjection:250mg(ashydrochloride)invial.

6 .2 .3 An t i l ep rosy m ed icines

Medicinesusedinthetreatmentofleprosyshouldneverbeusedexceptincombination.Combination

therapyisessentialtopreventtheemergenceofdrugresistance.Colourcodedblisterpacks(MDTblister

packs)containingstandardtwomedicine(paucibacillaryleprosy)orthreemedicine(multibacillary

leprosy)combinationsforadultandchildhoodleprosyshouldbeused.MDTblisterpackscanbesupplied

freeofchargethroughWHO.

clofazimine Capsule:50mg;100mg.

dapsone Tablet:25mg;50mg;100mg.

rifampicin Capsuleortablet:150mg;300mg.

6.2 .4 Ant i tubercu los is med ic ines

ethambutol Tablet:100400mg(hydrochloride).

isoniazidTablet:100300mg.

Tablet(scored):50mg.

isoniazid+ethambutol Tablet:150mg+400mg.

pyrazinamide

Tablet:400mg.

Tablet(dispersible):150mg.

Tablet(scored):150mg.

rifampicin Capsuleortablet:150mg;300mg.

rifampicin+isoniazid

Tablet:

60mg+30mg;150mg+75mg;300mg+150mg.

60mg+60mg(Forintermittentusethreetimesweekly).

150mg+150mg(Forintermittentusethreetimesweekly).

rifampicin+isoniazid+ethambutol Tablet: 150mg+75mg+275mg.

rifampicin+isoniazid+pyrazinamide

Tablet:

60mg+30mg+150mg;150mg+75mg+400mg.

150mg+150mg+500mg(Forintermittentusethreetimes

weekly).

rifampicin+isoniazid+pyrazinamide

+ethambutolTablet:150mg+75mg+400mg+275mg.

streptomycin Powderforinjection:1g(assulfate)invial.

ComplementaryList

Reservesecondlinedrugsforthetreatmentofmultidrugresistanttuberculosis(MDRTB)shouldbeused

inspecializedcentresadheringtoWHOstandardsforTBcontrol.

amikacin Powderforinjection:1000mginvial.


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EML 15, page - 9

paminosalicylicacidGranules:4ginsachet.

Tablet:500mg.

capreomycin Powderforinjection:1000mginvial.

cycloserine Capsuleortablet:250mg.

ethionamide Tablet:125mg;250mg.

kanamycin Powderforinjection:1000mginvial.

ofloxacin*

Tablet:200mg;400mg.

*Levofloxacinmaybeanalternative basedonavailabilityand

programmeconsiderations.

6.3 Antifungal medicinesclotrimazole

Vaginalcream:1%;10%.

Vaginaltablet:100mg;500mg.

fluconazole

Injection:2mg/mlinvial.

Capsule:50mg.


griseofulvin Capsuleortablet:125mg;250mg.

nystatin

Lozenge:100000IU.

Pessary:100000IU.

Tablet:100000IU;500000IU.

ComplementaryList

amphotericinB Powderforinjection:50mginvial.

flucytosineCapsule:250mg.

Infusion:2.5gin250ml.

potassiumiodide Saturatedsolution.

6.4 Antiviral medicines6.4 .1 Ant iherpes med ic inesaciclovir

Powderforinjection:250mg(assodiumsalt)invial.

Tablet:200mg.


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EML 15, page - 10

6 .4 .2 An t i r e t r ov i r a l s Basedoncurrentevidenceandexperienceofuse,medicinesinthefollowingthreeclassesofantiretrovirals

areincludedasessentialmedicinesfortreatmentandpreventionofHIV(preventionofmothertochild

transmissionandpostexposureprophylaxis).TheCommitteeemphasizestheimportanceofusingthese

productsinaccordancewithglobalandnationalguidelines. TheCommitteerecommendsandendorses

theuseoffixeddosecombinationsandthedevelopmentofappropriatenewfixeddosecombinations,

includingmodifieddosageforms,nonrefrigeratedproductsandpaediatricdosageformswithassured

pharmaceuticalquality.

6 .4 .2 .1 Nuc leos ide/ Nuc leo t i de reve rse t r anscr ip tase i nh ib i to r s abacavir(ABC)

Tablet:300mg(assulfate).

Oralliquid:100mg(assulfate)/5ml.

didanosine(ddI)

Capsule(unbufferedentericcoated):125mg;200mg;250mg;

400mg.

Tablet(bufferedchewable,dispersible):25mg;50mg;100mg;

150mg;200mg.

Bufferedpowderfororalliquid:100mg;167mg;250mgpackets.

emtricitabine(FTC)*

Capsule:200mg.

Oralliquid:10mg/ml.

*3TCisanacceptablealternativetoFTC,basedonknowledgeof

thepharmacology,theresistancepatternsandclinicaltrialsof

antiretrovirals.

lamivudine(3TC)Tablet:150mg.


stavudine(d4T)

Capsule:15mg;20mg;30mg;40mg.*

*TheCommitteeexpectsthisdosageformtobereviewedfor

possibledeletionatthenextmeeting.

Powderfororalliquid:5mg/5ml.

tenofovirCapsule:300mg(tenofovirdisoproxilfumarate equivalentto245

mgtenofovirdisoproxil).

zidovudine(ZDVorAZT)

SolutionforIVinfusioninjection:10mg/mlin20mlvial.

Capsule:100mg;250mg.

Tablet:300mg.


6.4 .2 .2 Non-nuc leos ide reverse t ranscr ip t ase inh ib i t o rs

efavirenz(EFVorEFZ)

Capsule:50mg;100mg;200mg.

Tablet:600mg.



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EML 15, page - 11

nevirapine(NVP)Tablet:200mg.


6.4 .2 .3 Pro t ease inh ib i t o rs

Selectionof proteaseinhibitor(s)fromtheModelListwillneedtobedeterminedbyeachcountryafter

considerationofinternationalandnationaltreatmentguidelinesandexperience.Ritonavirisrecommended

foruseincombinationasapharmacologicalbooster,andnotasanantiretroviralinitsownright.

ThissectionwillbereviewedbytheCommitteeasapriorityatitsnextmeeting.Itisexpectedthat

applicationforaheatstabletabletformulationcontaining200/50mglopinavir+ritonavirwillbesubmitted

forthenextmeeting.

indinavir(IDV) Capsule:200mg;333mg;400mg(assulfate).

lopinavir+ritonavir(LPV/r)Capsule:133.3mg+33.3mg.

Oralliquid:400mg+100mg/5ml.

nelfinavir(NFV)Oralpowder:50mg/g.

Tablet:250mg(asmesilate).

ritonavirOralsoliddosageform:100mg.


saquinavir(SQV) Capsule:200mg.

FI XED-DOSE COMBI NATI ONS

efavirenz+emtricitabine*+tenofovir Tablet:600mg+200mg+300mg.



antiretrovirals.

emtricitabine*+tenofovir Tablet:200mg+300mg.



antiretrovirals.

stavudine+lamivudine+nevirapine Tablet:30mg+150mg+200mg.

zidovudine+lamivudine Tablet:300mg+150mg.

zidovudine+lamivudine+

nevirapine

Tablet:300mg+150mg+200mg.

6 .4 .3 Othe r an t i v i r a l s

ribavirin

Injectionforintravenousadministration:1000mgand800mgin

10mlphosphatebuffersolution.

Oralsoliddosageforms:200mg;400mg;600mg.

6.5 Antipro tozoal medicines

6.5 .1 Ant iam oeb ic and an t ig ia rd ias is m ed ic ines

diloxanide Tablet:500mg(furoate).


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EML 15, page - 12

metronidazole

Injection:500mgin100mlvial.

Oralliquid:200mg(asbenzoate)/5ml.

Tablet:200500mg.

6.5 .2 Ant i le ishman ias is med ic ines

meglumineantimoniateInjection,30%,equivalenttoapproximately8.1%antimonyin

5mlampoule.

paromomycin Solutionforintramuscularinjection:750mg/2ml(assulfate).

ComplementaryList

amphotericinB Powderforinjection:50mginvial.

pentamidine Powderforinjection:200mg;300mg(isetionate)invial.

6 .5 .3 An t im a lar i a l m ed icines 6 .5 .3 .1 Fo r cu ra t i ve t r ea tm en t MedicinesforthetreatmentofP.falciparummalariacasesshouldbeusedincombination. Thelistcurrently

recommendscombinationsaccordingtotreatmentguidelines. TheCommitteerecognizesthatnotallof

theseFDCsexistandencouragestheirdevelopmentandrigoroustesting. TheCommitteealsoencourages

developmentandtestingofrectaldosageformulations.

amodiaquine*

Tablet:153mgor200mg(ashydrochloride).

*Tobeused(a)incombinationwithartesunate50mgOR

(b)maybeusedaloneforthetreatmentofP.vivax,P.ovaleand

P.malariae

infections.

artemetherOilyinjection:80mg/mlin1mlampoule.

Foruseinthemanagementofseveremalaria.

artemether+lumefantrine*

Tablet:20mg+120mg.

*Notrecommendedinthefirsttrimesterofpregnancyorin

childrenbelow5kg.

artesunate*

Injection:ampoules,containing60mganhydrousartesunicacid

withaseparateampouleof5%sodiumbicarbonatesolution.

Foruseinthemanagementofseveremalaria.

Tablet:50mg.

*Tobeusedincombinationwitheitheramodiaquine,mefloquine

orsulfadoxine+pyrimethamine.

chloroquineTablet:100mg;150mg(asphosphateorsulfate).

Oralliquid:50mg(asphosphateorsulfate)/5ml.

doxycycline*

Capsule:100mg(ashydrochloride).

Tablet(dispersible):100mg(asmonohydrate).

*Foruseonlyincombinationwithquinine.


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EML 15, page - 13

mefloquine*Tablet:250mg(ashydrochloride).

*Tobeused incombinationwithartesunate50mg.

primaquine*

Tablet:7.5mg;15mg(asdiphosphate)

*OnlyforusetoachieveradicalcureofP.vivaxandP.ovale

infections,givenfor14days.

quinine*

Injection:300mgquininehydrochloride/mlin2mlampoule.

Tablet:300mg(quininesulfate)or300mg(quininebisulfate).

*Foruseonlyinthemanagementofseveremalaria,andshouldbe

usedincombinationwithdoxycycline.

sulfadoxine+pyrimethamine*Tablet:500mg+25mg.

*Onlyincombinationwithartesunate50mg.

6.5 .3 .2 For p roph y lax is

chloroquine*

Tablet:150mg(asphosphateorsulfate).

Oralliquid:50mg(asphosphateorsulfate)/5ml.

*ForuseonlyincentralAmericanregions,foruseforP.vivax.

doxycycline Capsuleortablet:100mg(hydrochloride).

mefloquine Tablet:250mg(ashydrochloride).

proguanil*Tablet:100mg(hydrochloride).

*Foruseonlyincombinationwithchloroquine.

6 .5 .4 An t i - pneum ocystos i s and an t i t oxop lasm os is med ic ines

pyrimethamine Tablet:25mg.

sulfamethoxazole+trimethoprimInjection:80mg+16mg/mlin5mlampoule;

80mg+16mg/mlin10mlampoule.

ComplementaryList

pentamidine Tablet:200mg;300mg.

6 .5 .5 An t i t r y panosom a l med ic ines 6 .5 .5 .1 A f r i can t r y panosom iasi s Medicinesforthetreatmentof1ststageAfricantrypanosomiasis

pentamidine*

Powderforinjection:200mg(pentamidineisetionate)invial.

*TobeusedforthetreatmentofTrypansomabruceigambiense

infection.

suraminsodium* Powderforinjection:1ginvial.

*Tobeusedexclusivelyforthetreatmentoftheinitialphaseof

Trypansomabruceirhodesienseinfection.

Medicinesforthetreatmentof2ndstageAfricantrypanosomiasis

eflornithine Injection:200mg(hydrochloride)/mlin100mlbottle.


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EML 15, page - 14

melarsoprol Injection:3.6%solution,5mlampoules(180mgofactive

compound).

6 .5 .5 .2 Amer i can t r i panosomiasi s benznidazole Tablet:100mg.

nifurtimox Tablet:30mg;120mg;250mg.

7. ANTIMIGRAINE MEDICINES

7.1 For treatment of acute attack

acetylsalicylicacid Tablet:300500mg.

paracetamol Tablet:300500mg.

7.2 For prophylaxis

propranolol Tablet:20mg;40mg(hydrochloride).

8. ANTINEOPLASTIC, IMMUNOSUPPRESSIVES AND MEDICINES USED INPALLI ATIVE CARE

8.1 Immunosuppressive medicines

ComplementaryList

azathioprinePowderforinjection:100mg(assodiumsalt)invial.

Tablet:50mg.

ciclosporin

Concentrateforinjection:50mg/mlin1mlampoulefororgan

transplantation.

Capsule:25mg.

8.2 Cytotoxic medicines

Thissectionisexpectedtobereviewedatthenextmeeting.

ComplementaryList

asparaginase Powderforinjection:10000IUinvial.

bleomycin Powderforinjection:15mg(assulfate)invial.

calciumfolinateInjection:3mg/mlin10mlampoule.

Tablet:15mg.

chlorambucil Tablet:2mg.

cisplatin Powderforinjection:10mg;50mginvial.

cyclophosphamidePowderforinjection:500mginvial.

Tablet:25mg.

cytarabine Powderforinjection:100mginvial.

dacarbazine Powderforinjection:100mginvial.

dactinomycin Powderforinjection:500microgramsinvial.

daunorubicin Powderforinjection:50mg(ashydrochloride).


15/32


EML 15, page - 15

doxorubicin Powderforinjection:10mg;50mg(hydrochloride)invial.

etoposideInjection:20mg/mlin5mlampoule.

Capsule:100mg.

fluorouracil Injection:50mg/mlin5mlampoule.

mercaptopurine Tablet:50mg.

methotrexatePowderforinjection:50mg(assodiumsalt)invial.

Tablet:2.5mg(assodiumsalt).

procarbazine Capsule:50mg(ashydrochloride).

vinblastine Powderforinjection:10mg(sulfate)invial.

vincristine Powderforinjection:1mg;5mg(sulfate)invial.

8.3 Hormones and antihormonesComplementaryList

dexamethasoneInjection:4mgdexamethasonephosphate(asdisodiumsalt)in

1mlampoule.

hydrocortisone Powderforinjection:100mg(assodiumsuccinate)invial.

prednisolone*

Tablet:5mg;25mg.

*Thereisnoevidenceforcompleteclinicalsimilaritybetween

prednisoloneanddexamethasoneathighdoses.

tamoxifen Tablet:10mg;20mg(ascitrate).

8.4 Medicines used in palliative care

TheWHOExpertCommitteerecognizestheimportanceoflistingspecificmedicinesinthePalliativeCare

Section. SomemedicinescurrentlyusedinpalliativecareareincludedintherelevantsectionsoftheModel

List,accordingtotheirtherapeuticuse,e.g.analgesics. TheGuidelinesforPalliativeCarethatwere

referencedinthepreviouslistareinneedofupdate. TheCommitteeexpectsapplicationsformedicines

neededforpalliativecaretobesubmittedforthenextmeeting.

9. ANTIP ARKINSONISM MEDICINESbiperiden

Injection:5mg(lactate)in1mlampoule.

Tablet:2mg(hydrochloride).

levodopa+carbidopa Tablet:100mg+10mg;250mg+25mg.

10. MEDICINES AFFECTING THE BLOOD10.1 Antianaemia medicinesferroussalt

Tablet:equivalentto60mgiron.

Oralliquid:equivalentto25mgiron(assulfate)/ml.

ferroussalt+folicacidTabletequivalentto60mgiron+400microgramsfolicacid

(Nutritionalsupplementforuseduringpregnancy).

folicacid Tablet:1mg;5mg.


16/32


EML 15, page - 16

hydroxocobalamin Injection:1mgin1mlampoule.

10.2 Medicines affecting coagulationheparinsodium Injection:1000IU/ml;5000IU/ml;20,000IU/mlin1mlampoule.

phytomenadioneInjection:10mg/mlin5mlampoule.

Tablet:10mg.

protaminesulfate Injection:10mg/mlin5mlampoule.

warfarin Tablet:1mg;2mg;5mg(sodiumsalt).

11. BLOOD PRODUCTS AND P LASMA SUBSTITUTES11.1 Plasma substitutesdextran70*

Injectablesolution:6%.

*Polygeline,injectablesolution,3.5%isconsideredasequivalent.

11.2 Plasma fractions for specific useAllplasmafractionsshouldcomplywiththeWHORequirementsfortheCollection,Processingand

QualityControlofBlood,BloodComponentsandPlasmaDerivatives(Revised1992).(WHOTechnical

ReportSeries,No.840,1994,Annex2).

ComplementaryList

humannormalimmunoglobulin Intravenousadministration:5%,10%proteinsolution.

Intramuscularadministration:16%proteinsolution.

factorVIIIconcentrate Dried.

factorIXcomplex(coagulation

factors,II,VII,IX,X)concentrateDried.

12. CARDIOVASCULAR MEDICINES12.1 Antianginal medicinesatenolol Tablet:50mg;100mg.

glyceryltrinitrate Tablet(sublingual):500micrograms.

isosorbidedinitrate Tablet(sublingual):5mg.

verapamil Tablet:40mg;80mg(hydrochloride).

12.2 Antiarrhythmic medicinesThissubsectionwillbereviewedatthenextmeetingoftheExpertCommittee.

atenolol Tablet:50mg;100mg.

digoxin

Injection:250micrograms/mlin2mlampoule.

Tablet:62.5micrograms;250micrograms.

Oralliquid:50micrograms/ml.

epinephrine(adrenaline) Injection:100micrograms/ml(asacidtartrateorhydrochloride)in

10mlampoule.

lidocaine Injection:20mg(hydrochloride)/mlin5mlampoule.


17/32


EML 15, page - 17

verapamilInjection:2.5mg(hydrochloride)/mlin2mlampoule.

Tablet:40mg;80mg(hydrochloride).

ComplementaryList

procainamide Injection:100mg(hydrochloride)/mlin10mlampoule.

quinidine Tablet:200mg(sulfate).

12.3 Antihypertensive medicines

amlodipine Tablet:5mg.

atenolol Tablet:50mg;100mg.

enalapril Tablet:2.5mg.

hydralazine*

Powderforinjection:20mg(hydrochloride)inampoule.

Tablet:25mg,50mg(hydrochloride).

*Hydralazineislistedforuseintheacutemanagementofsevere

pregnancyinducedhypertensiononly.Itsuseinthetreatmentof

essentialhypertensionisnotrecommendedinviewofthe

availabilityofmoreevidenceofefficacyandsafetyofother

medicines.

hydrochlorothiazide Tablet(scored):25mg.

methyldopa*

Tablet:250mg.

*Methyldopaislistedforuseinthemanagementofpregnancy

inducedhypertensiononly.Itsuseinthetreatmentofessential

hypertensionisnotrecommendedinviewoftheavailabilityof

moreevidenceofefficacyandsafetyofothermedicines.

ComplementaryList

sodiumnitroprusside Powderforinfusion:50mginampoule.

12.4 Medicines used in heart failure

ThissubsectionwillbereviewedatthenextmeetingoftheExpertCommittee.

digoxin

Injection:250micrograms/mlin2mlampoule.

Tablet:62.5micrograms;250micrograms.

Oralliquid:50micrograms/ml.

enalapril Tablet:2.5mg.

furosemideInjection:10mg/mlin2mlampoule.

Tablet:40mg.


ComplementaryList

dopamine Injection:40mg(hydrochloride)in5mlvial.


18/32


EML 15, page - 18

12.5 Antithrombotic medicines

acetylsalicylicacid Tablet:100mg.

ComplementaryList

streptokinase Powderforinjection:1.5millionIUinvial.

12.6 Lipid-lowering agents

simvastatin*Tablet:5mg;10mg;20mg;40mg.

*Foruseinhighriskpatients.

13. DERMATOLOGICAL MEDICINES (topical)

13.1 Antifungal medicines

benzoicacid+salicylicacid Ointmentorcream:6%+3%.

miconazole Ointmentorcream:2%(nitrate).

sodiumthiosulfate Solution:15%.

ComplementaryList

seleniumsulfide Detergentbasedsuspension:2%.

13.2 Anti-infective medicines

methylrosaniliniumchloride

(gentianviolet)

Aqueoussolution:0.5%.

Tincture:0.5%.

neomycinsulfate+bacitracin Ointment:5mgneomycinsulfate+250IUbacitracinzinc/g.

potassiumpermanganate Aqueoussolution:1:10000.

silversulfadiazine Cream:1%,in500gcontainer.

13.3 Anti-inflammatory and antipruritic medicines

betamethasone Ointmentorcream:0.1%(asvalerate).

calaminelotion Lotion.

hydrocortisone Ointmentorcream:1%(acetate).

13.4 Astringent medicines

aluminiumdiacetate Solution:5%.

13.5 Medicines affecting skin differentiation and proliferation

benzoylperoxide Lotionorcream:5%.

coaltar Solution:5%.

dithranol Ointment:0.1%2%.

fluorouracil Ointment:5%.

podophyllum

resin

Solution:

10

25%.

salicylicacid Solution:5%.


19/32


EML 15, page - 19

urea Ointmentorcream:10%.

13.6 Scabicides and pediculicides

benzylbenzoate Lotion:25%.

permethrinCream:5%.

Lotion:1%.

14. DIAGNOSTIC AGENTS

14.1 Ophthalmic medicines

fluorescein Eyedrops:1%(sodiumsalt).

tropicamide Eyedrops:0.5%.

14.2 Radiocontrast media

amidotrizoate Injection:140420mgiodine(assodiumormegluminesalt)/mlin

20mlampoule.

bariumsulfate Aqueoussuspension.

iohexol Injection:140350mgiodine/mlin5ml;10ml;20mlampoule.

ComplementaryList

meglumineiotroxate Solution:58giodinein100250ml.

15. DISINFECTANTS AND ANTI SEPTI CS15.1 Antisepticschlorhexidine Solution:5%(digluconate)fordilution.

ethanol Solution:70%(denatured).

polyvidoneiodine Solution:10%.

15.2 Disinfectants

chlorinebasecompound Powder:(0.1%availablechlorine)forsolution.

chloroxylenol Solution:4.8%.

glutaral Solution:2%.

16. DIURETICS

amiloride Tablet:5mg(hydrochloride).

furosemideInjection:10mg/mlin2mlampoule.

Tablet:40mg.


mannitol Injectablesolution:10%;20%.

spironolactone Tablet:25mg.


20/32


EML 15, page - 20

17. GASTROINTESTINAL MEDICINES

17.1 Antacids and other antiulcer medicines

aluminiumhydroxideTablet:500mg.


ranitidine

Injection:25mg/mlin2mlampoule.

Tablet:150mg(ashydrochloride).


magnesiumhydroxide Oralliquid:equivalentto550mgmagnesiumoxide/10ml.

17.2 Antiemetic medicines

metoclopramideInjection:5mg(hydrochloride)/mlin2mlampoule.


promethazine

Injection:25mg(hydrochloride)/mlin2mlampoule.

Tablet:10mg;25mg(hydrochloride).

Oralliquid:5mg(hydrochloride)/5ml.

17.3 Anti-inflammatory medicines

sulfasalazine

Tablet:500mg.

Retentionenema.

Suppository:

500

mg.

ComplementaryList

hydrocortisone

Retentionenema.

Suppository:25mg(acetate).

(theonlyappliestohydrocortisoneretentionenema).

17.4 Laxatives

senna Tablet:7.5mg(sennosides)(ortraditionaldosageforms).


21/32


EML 15, page - 21

17.5 Medicines used in diarrhoea

17 .5 .1 Ora l r ehyd ra t i on

oralrehydrationsalts*

glucose: 75mEq

sodium: 75mEqormmol/l

chloride: 65mEqormmol/l

potassium: 20mEqormmol/l

citrate: 10mmol/l

osmolarity: 245mOsm/l

glucose: 13.5g/l

sodiumchloride: 2.6g/l

potassiumchloride: 1.5g/l

trisodiumcitratedihydrate+: 2.9g/l

+trisodiumcitratedihydratemaybereplacedbysodium

hydrogencarbonate(sodiumbicarbonate)2.5g/l.However,asthe

stabilityofthislatterformulationisverypoorundertropical

conditions,itisonlyrecommendedwhenmanufacturedfor

immediateuse.

*Incasesofcholeraahigherconcentrationofsodiummaybe

required.

17.5 .2 Med ic ines fo r d ia r rhoea in ch i ld ren

zincsulfate*

Tablet:in10mgperunitdosageforms.

Oralliquid:in10mgperunitdosageforms.

*

In

acute

diarrhoea

zinc

sulfate

should

be

used

as

an

adjunct

to

oralrehydrationsalts.

17 .5 .3 An t i d ia r rhoea l ( sym p tom a t i c ) m ed icines i n adu l t s

codeine*

Tablet:30mg(phosphate).

*Theroleofthisitemhasbeenquestionedanditscontinued

inclusiononthelistwillbereviewedatthenextmeetingofthe

ExpertCommittee.

18. HORMONES, OTHER ENDOCRINE MEDICINES AND CONTRACEPTIVES

18.1 Adrenal hormones and synthetic substitutes

Addisonsdiseaseisararecondition;adrenalhormonesarealreadyincludedinsection3.

18.2 Androgens

ComplementaryList

testosterone Injection:200mg(enantate)in1mlampoule.

18.3 Contraceptives

18 .3 .1 Ora l ho rm ona l con t racep t i ves

ethinylestradiol+levonorgestrel Tablet:30micrograms+150micrograms.

ethinylestradiol+norethisterone Tablet:35micrograms+1.0mg.

levonorgestrel Tablet:30micrograms;750micrograms(packoftwo);1.5mg.


22/32


EML 15, page - 22

18 .3 .2 I n jec tab le ho rmona l con t racep t i ves

medroxyprogesteroneacetate Depotinjection:150mg/mlin1mlvial.

medroxyprogesteroneacetate+

estradiolcypionateInjection:25mg+5mg.

norethisteroneenantate Oilysolution:200mg/mlin1mlampoule.

18 .3 .3 I n t r au te r i ne dev i ces

coppercontainingdevice

18 .3 .4 Ba r r i e r m e thods

condoms

diaphragms

18.3.5 Implantable contraceptives

levonorgestrelreleasingimplantTworodlevonorgestrelreleasingimplant,eachrodcontaining

75mgoflevonorgestrel(150mgtotal).

18.4 Estrogens

ethinylestradiol*

Tablet:10micrograms;50micrograms.

*Thepublichealthrelevanceand/orcomparativeefficacyand/or

safetyofthisitemhasbeenquestionedanditscontinuedinclusion

onthelistwillbereviewedatthenextmeetingoftheExpert

Committee.

18.5 Insulins and other antidiabetic agents

glibenclamide Tablet:2.5mg;5mg.

insulininjection(soluble) Injection:40IU/mlin10mlvial;100IU/mlin10mlvial.

intermediateactinginsulinInjection:40IU/mlin10mlvial;100IU/mlin10mlvial

(ascompoundinsulinzincsuspensionorisophaneinsulin).

metformin Tablet:500mg(hydrochloride).

18.6 Ovulation inducers

ComplementaryList

clomifene Tablet:50mg(citrate).

18.7 Progestogens

norethisterone*

Tablet:5mg.


safetyofthisitemhasbeenquestionedanditscontinuedinclusion


Committee.


23/32


EML 15, page - 23

ComplementaryList

medroxyprogesteroneacetate*

Tablet:5mg.


safety

of

this

item

has

been

questioned

and

its

continued

inclusion


Committee.

18.8 Thyroid hormones and antithyroid medicines levothyroxine Tablet:50micrograms;100micrograms(sodiumsalt).

potassiumiodide Tablet:60mg.

propylthiouracil Tablet:50mg.

19. IMMUNOLOGICALS

19.1 Diagnostic agents

AlltuberculinsshouldcomplywiththeWHORequirementsforTuberculins(Revised1985).WHOExpert

CommitteeonBiologicalStandardization.Thirtysixthreport.(WHOTechnicalReportSeries,No.745,

1987,Annex1).

tuberculin,purifiedproteinderivative

(PPD)Injection.

19.2 Sera and immunoglobulins

AllplasmafractionsshouldcomplywiththeWHORequirementsfortheCollection,Processingand

QualityControlofBlood,BloodComponentsandPlasmaDerivatives(Revised1992).WHOExpert

CommitteeonBiologicalStandardization.Fortythirdreport.(WHOTechnicalReportSeries,No.840,1994,

Annex2).

antiDimmunoglobulin(human) Injection:250microgramsinsingledosevial.

antitetanusimmunoglobulin(human) Injection:500IUinvial.

antivenomimmunoglobulin*Injection.

*Exacttypetobedefinedlocally.

diphtheriaantitoxin Injection:10000IU;20000IUinvial.

rabiesimmunoglobulin Injection:150IU/mlinvial.

19.3 Vaccines

SelectionofvaccinesfromtheModelListwillneedtobedeterminedbyeachcountryafterconsiderationof

internationalrecommendations,epidemiologyandnationalpriorities.Thelistbelowdetailsthevaccines

forwhichthereiseitherarecommendationfromtheStrategicAdvisoryGroupofExpertsonImmunization

(SAGE)(http://www.who.int/immunization/sage_conclusions/en/index.html)and/oraWHOposition

paper(http://www.who.int/immunization/documents/positionpapers/en/index.html).Thissitewillbe

updatedasnewpositionpapersarepublishedandcontainsthemostrecentinformationand

recommendations.

AllvaccinesshouldcomplywiththeWHORequirementsforBiologicalSubstances.

BCGvaccine

choleravaccine
http://www.who.int/immunization/sage_conclusions/en/index.htmlhttp://www.who.int/immunization/documents/positionpapers/en/index.htmlhttp://www.who.int/immunization/documents/positionpapers/en/index.htmlhttp://www.who.int/immunization/sage_conclusions/en/index.html


24/32


EML 15, page - 24

diphtheriavaccine

hepatitisAvaccine

hepatitisBvaccine

Haemophilusinfluenzaetypebvaccine

influenzavaccine

Japaneseencephalitisvaccine

measlesvaccine

meningococcalmeningitisvaccine

mumpsvaccine

pertussisvaccine

pneumococcalvaccine

poliomyelitisvaccine

rabiesvaccine

rotavirusvaccine

rubellavaccine

tetanusvaccine

typhoidvaccine

varicellavaccine

yellowfevervaccine

20. MUSCLE RELAXANTS (PERIPHERALLY -ACTING) AND CHOLINESTERASEINHIBITORS

alcuronium Injection:5mg(chloride)/mlin2mlampoule

neostigmine

Injection:500microgramsin1mlampoule;2.5mg(metilsulfate)

in1mlampoule.

Tablet:15mg(bromide).

suxamethoniumInjection:50mg(chloride)/mlin2mlampoule.

Powderforinjection(chloride),invial.

ComplementaryList

pyridostigmineInjection:1mgin1mlampoule.

Tablet:60mg(bromide).

vecuronium Powderforinjection:10mg(bromide)invial.


25/32


EML 15, page - 25

21. OPHTHALMOLOGICAL PREPARATIONSThissectionwillbereviewedatthenextmeetingoftheExpertCommittee.

21.1 Anti-infective agentsaciclovir Ointment:3%W/W.

gentamicin*Solution(eyedrops):0.3%(sulfate).


tetracycline Eyeointment:1%(hydrochloride).

21.2 Anti-inflammatory agents

prednisolone Solution(eyedrops):0.5%(sodiumphosphate).

21.3 Local anaesthetics

tetracaine Solution(eyedrops):0.5%(hydrochloride).

21.4 Miotics and antiglaucoma medicines

acetazolamide Tablet:250mg.

pilocarpine Solution(eyedrops):2%;4%(hydrochlorideornitrate).

timolol Solution(eyedrops):0.25%;0.5%(asmaleate).

21.5 Mydriatics

atropine Solution(eyedrops):0.1%;0.5%,1%(sulfate).

ComplementaryList

epinephrine(adrenaline) Solution(eyedrops):2%(ashydrochloride).

22. OXYTOCICS AND ANTIOXYTOCICS

22.1 Oxytocics

ergometrine Injection:200micrograms(hydrogenmaleate)in1mlampoule.

oxytocin Injection:10IUin1mlampoule.

ComplementaryList

misoprostol

Vaginal

tablet:

25

micrograms.

mifepristone*misoprostol*

Wherepermittedunder

nationallawandwhere

culturallyacceptable.

Tablet200mgtablet200micrograms.

*Requiresclosemedicalsupervision.

22.2 Antioxytocics (tocolytics)

nifedipine Immediatereleasecapsule:10mg.


26/32


EML 15, page - 26

23. PERITONEAL DIALY SIS SOLUTION

ComplementaryList

intraperitonealdialysissolution(of

appropriate

composition)

Parenteralsolution.

24. PSYCHOTHERAPEUTIC MEDICINES

24.1 Medicines used in psychotic disorders

chlorpromazine

Injection:25mg(hydrochloride)/mlin2mlampoule.


Oralliquid:25mg(hydrochloride)/5ml.

fluphenazine Injection:25mg(decanoateorenantate)in1mlampoule.

haloperidolInjection:5mgin1mlampoule.

Tablet:2mg;5mg.

24.2 Medicines used in mood disorders

24.2 .1 Med ic ines used in depress ive d isorders

amitriptyline Tablet:25mg(hydrochloride).

fluoxetine Capsuleortablet:20mg(presentashydrochloride).

24.2 .2 Med ic ines used in b ipo la r d isorders

carbamazepine Tablet(scored):100mg;200mg.

lithiumcarbonate Capsuleortablet:300mg.

valproicacid Tablet(entericcoated):200mg;500mg(sodiumvalproate).

24.3 Medicines used in generalized anxiety and sleep disorders

diazepam Tablet(scored):2mg;5mg.

24.4 Medicines used for obsessive compu lsive disorders and panic attacks

clomipramine Capsule:10mg;25mg(hydrochloride).

24.5 Medicines used in substance dependence programmes

ComplementaryList

methadone*

Concentratefororalliquid:5mg/ml;10mg/ml(hydrochloride).

Oralliquid:5mg/5ml;10mg/5ml.

*Thesquareboxisaddedtoincludebuprenorphine.Themedicines

shouldonlybeusedwithinanestablishedsupportprogramme.

25. MEDICINES ACTING ON THE RESPI RATORY TRACT

25.1 Antiasthmatic and medicines for chronic obstructive pulmonary disease

beclometasone Inhalation(aerosol):50microgramsperdose(dipropionate);250micrograms(dipropionate)perdose.


27/32


EML 15, page - 27

epinephrine(adrenaline)Injection:1mg(ashydrochlorideorhydrogentartrate)in

1mlampoule.

ipratropiumbromide Inhalation(aerosol):20micrograms/metereddose.

salbutamol

Injection:50micrograms(assulfate)/mlin5mlampoule.

Tablet:2mg;4mg(assulfate).

Oralliquid:2mg/5ml.

Inhalation(aerosol):100micrograms(assulfate)perdose.

Respiratorsolutionforuseinnebulizers:5mg(assulfate)/ml.

25.2 Other medicines acting on the respiratory tract

caffeinecitrateInjection:20mg/ml(equivalentto10mgcaffeinebase/ml).

Oralliquid:20mg/ml(equivalentto10mgcaffeinebase/ml).

26. SOLUTIONS CORRECTING WATER, ELECTROLYTE AND ACID-BASEDISTURBANCES

26.1 Oral

oralrehydrationsalts Seesection17.5.1.

potassiumchloride Powderforsolution.

26.2 Parenteral

glucose Injectablesolution:5%;10%isotonic;50%hypertonic.

glucosewithsodiumchlorideInjectablesolution:4%glucose,0.18%sodiumchloride

(equivalenttoNa+30mmol/l,Cl 30mmol/l).

potassiumchlorideSolution:11.2%in20mlampoule

(equivalenttoK+1.5mmol/ml,Cl1.5mmol/ml).

sodiumchlorideInjectablesolution:0.9%isotonic(equivalenttoNa+154mmol/l,

Cl 154mmol/l.

sodiumhydrogencarbonate

Injectablesolution:1.4%isotonic(equivalenttoNa+167mmol/l,

HCO3 167mmol/l).

Solution:8.4%in10mlampoule(equivalenttoNa+1000mmol/l,

HCO3

1000

mmol/l).

sodiumlactate,compoundsolution Injectablesolution.

26.3 Miscellaneous

waterforinjection 2ml;5ml;10mlampoules.

27. VITAMI NS AND MINERALS

ascorbicacid Tablet:50mg.

ergocalciferolCapsuleortablet:1.25mg(50000IU).

Oral

liquid:

250

micrograms/ml

(10

000

IU/ml).


28/32


EML 15, page - 28

iodine

Capsule:200mg.

Iodizedoil:1ml(480mgiodine);0.5ml(240mgiodine)in

ampoule(oralorinjectable);0.57ml(308mgiodine)indispenser

bottle.

nicotinamide Tablet:50mg.

pyridoxine Tablet:25mg(hydrochloride).

retinol

Watermiscibleinjection:100000IU(aspalmitate)in

2mlampoule.

Capsule:50000IU;100000IU;200000IU(aspalmitate).

Tablet(sugarcoated):10000IU(aspalmitate).

Oraloilysolution:100000IU(aspalmitate)/mlinmultidose

dispenser.

riboflavin Tablet:5mg.

sodiumfluoride Inanyappropriatetopicalformulation.

thiamine Tablet:50mg(hydrochloride).

ComplementaryList

calciumgluconate Injection:100mg/mlin10mlampoule.


29/32


EML 15, page - 29

Index

abacavir(ABC) ........................................................ 10

acetazolamide......................... ................................. 25

acetylcysteine ............................................................ 4

acetylsalicylicacid ........................................ 2,14,18

aciclovir .......................................................... ...... 9,25

albendazole.......... ...................................................... 5

alcuronium........................................... .................... 24

allopurinol ................................................................ . 3

aluminiumdiacetate..................................... .......... 18

aluminiumhydroxide ............................................ 20

amidotrizoate ....................................................... ... 19

amikacin.................................................... ................... 8

amiloride ....................................................... ........... 19

amitriptyline ............................................................ 26

amlodipine............................................................... 17

amodiaquine................... ......................................... 12

amoxicillin .................................................... ............. 6

amoxicillin+clavulanicacid ................................... 6

amphotericinB................................................. ...... 9,12

ampicillin ........................................................... ........ 6

antiDimmunoglobulin(human) ......................... 23

antitetanusimmunoglobulin(human)................. 23

antivenomimmunoglobulin ................................. 23

artemether................. ............................................... 12

artemether+lumefantrine..................................... 12

artesunate..................................... ............................ 12

ascorbicacid ................................................. ........... 27

asparaginase........................................................ ....... 14

atenolol............................................................... 16,17

atropine ............................................................ 2,4,25

azathioprine ........................................................ ... 3,14

azithromycin.................................... .......................... 7

bacitracin............................................................... ... 18

bariumsulfate ............................................... .......... 19

BCGvaccine......................................... .................... 23

beclometasone ......................................................... 26

benzathine benzylpenicillin .................................... 6

benznidazole............................................................ 14

benzoicacid ............................................................. 18

benzoicacid+salicylicacid................................... 18

benzoylperoxide..................................................... 18

benzylbenzoate....................................................... 19

benzylpenicillin......................................................... 6

betamethasone......................................................... 18

biperiden....................................................... ........... 15

bleomycin.................................................. ................. 14

bupivacaine............................................................... . 2

caffeinecitrate ......................................................... 27

calaminelotion ........................................................ 18

calciumfolinate................................................ .......... 14

calciumgluconate ............................................... 4,28

capreomycin .................................................... ............. 9

carbamazepine................................................... .. 4,26

carbidopa..................................................... ............. 15

cefazolin................................................................ ...... 6

cefixime..................................................................... .. 6

ceftazidime ...................................................... ............. 6

ceftriaxone....................................................... ............. 6

charcoal,activated..................................................... 4

chlorambucil.................................................... ........... 14

chloramphenicol................................................ ........ 7

chlorhexidine ........................................................... 19

chlorinebasecompound ........................................ 19

chloroquine .................................................... 3,12,13

chloroxylenol ........................................................... 19

chlorphenamine......................................................... 3

chlorpromazine ....................................................... 26

choleravaccine ........................................................ 23

ciclosporin....................................................... ........... 14

cilastatin ......................................................... ............. 6

ciprofloxacin ............................................................. . 7

cisplatin........................................................... ........... 14

clavulanicacid ......................................................... .. 6

clindamycin .................................................... ............. 7

clofazimine.................................................................8

clomifene ......................................................... ........... 22

clomipramine................................. .......................... 26

clotrimazole ........................................................... .... 9

cloxacillin .................................................... ............... 6

coaltar ......................................................... ............. 18

codeine........................................................ .......... 3,21

condoms ................................................................ ... 22

coppercontainingdevice.......................................22

cyclophosphamide ......................................................14

cycloserine....................................................... ............. 9

cytarabine........................................................ ........... 14

dacarbazine ..................................................... ........... 14

dactinomycin................................................... ........... 14

dapsone ....................................................... ............... 8

daunorubicin................................................... ........... 14

deferoxamine ............................................................. 4

dexamethasone............. ....................................... 3,15

dextran70.................................................................16

diaphragms .............................................................. 22

diazepam.................................................... ...... 2,4,26

didanosine(ddI)......................................................10

diethylcarbamazine ......................................................5

digoxin........ ........................................................ 16,17

diloxanide................................................................. 11

dimercaprol................................................. ............... 4


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EML 15, page - 30

diphtheriaantitoxin................................................ 23

diphtheriavaccine .................................................. 24

dithranol.................................... ............................... 18

DLmethionine .......................................................... 4

dopamine................................................... ................. 17

doxorubicin......................................................... ....... 15

doxycycline.................................................... 7,12,13

efavirenz............................................. ................ 10,11

efavirenz(EFVorEFZ)........................................... 10

efavirenz+emtricitabine+tenofovir ................... 11

eflornithine .............................................................. 13

emtricitabine.... .................................................. 10,11

emtricitabine(FTC)........ ......................................... 10

emtricitabine+tenofovir............................. ........... 11

enalapril ........................................................ ........... 17

ephedrine................................................... ................... 2

epinephrine(adrenaline) ................... 2,3,16,25,27

ergocalciferol ........................................................... 27

ergometrine.............................................................. 25

erythromycin ............................................................. 7

estradiolcypionate.................................................. 22

ethambutol.... ............................................................. 8

ethanol........................................................... ........... 19

ethinylestradiol ................................................. 21,22

ethinylestradiol+levonorgestrel .......................... 21

ethinylestradiol+norethisterone.......................... 21

ethionamide......................................................... ......... 9

ethosuximide....................................................... ......... 5

etoposide ................................................... ................. 15

factorIXcomplex(coagulationfactors,II,VII,IX,X)

concentrate..................................................... ....... 16

factorVIIIconcentrate............................................... 16

ferroussalt ............................................................... 15

ferroussalt+folicacid ........................................... 15

fluconazole.................................... ............................. 9

flucytosine........................................................... ......... 9

fluorescein................................... ............................. 19

fluorouracil ......................................................... . 15,18

fluoxetine ......................................................... ........ 26

fluphenazine...................................................... ...... 26

folicacid ............................................... .................... 15

furosemide......................................................... 17,19

gentamicin ........................................................... 7,25

gentianviolet........................................................... 18

glibenclamide .......................................................... 22

glucose............................................................ 2,21,27

glutaral ................................................................ ..... 19

glyceryltrinitrate .................................................... 16

griseofulvin............ .................................................... 9

Haemophilusinfluenzaetypebvaccine .................. 24

haloperidol..................................................... .......... 26

halothane............................................... ..................... 2

heparinsodium .................................................... ... 16

hepatitisAvaccine..................................................24

hepatitisBvaccine................................................... 24

humannormalimmunoglobulin................................16

hydralazine ............................................................ .. 17

hydrochlorothiazide ......................................... 17,19

hydrocortisone......................................... 3,15,18,20

hydroxocobalamin .................................................. 16

ibuprofen....................................................................2

imipenem......................................................... ............. 6

imipenem+cilastatin...................................................6

immunoglobulin ..................................................... 23

indinavir(IDV)........................................................11

influenzavaccine................................................. .... 24

insulin.......................................................................22

insulininjection(soluble).......................................22

intermediateactinginsulin....................................22

intraperitonealdialysissolution(ofappropriate

composition)..................................................... ..... 26

iodine .............................................................. .... 19,28

iohexol ....................................................... ............... 19

ipratropiumbromide..............................................27

isoniazid ....................................................... .............. 8

isoniazid+ethambutol ............................................. 8

isosorbidedinitrate.................................................16

ivermectin ............................................................. ..... 5

Japaneseencephalitisvaccine................................24

kanamycin....................................................... ............. 9

ketamine ..................................................................... 2

lamivudine ...................................................... ... 10,11

lamivudine(3TC) .................................................... 10

levamisole ................................................................ .. 5

levodopa.................... ............................................... 15

levodopa+carbidopa ............................................. 15

levonorgestrel.................................................... 21,22

levonorgestrelreleasingimplant..........................22

levothyroxine....... .................................................... 23

lidocaine ........................................................ ....... 2,16

lidocaine+epinephrine(adrenaline)......................2

lithiumcarbonate .................................................... 26

lopinavir ........................................................ ........... 11

lopinavir+ritonavir(LPV/r).................................. 11

lumefantrine ............................................................ 12

magnesiumhydroxide ........................................... 20

magnesiumsulfate....................................................4

mannitol ............................................................ ....... 19

measlesvaccine ..................................................... .. 24

mebendazole..................... ......................................... 5

medroxyprogesteroneacetate .........................22,23

medroxyprogesteroneacetate+estradiol

cypionate ............................................................ . 22

mefloquine ............................................................... 13


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EML 15, page - 31

meglumineantimoniate......................................... 12

meglumineiotroxate ................................................. . 19

melarsoprol................. ............................................. 14

meningococcalmeningitisvaccine ....................... 24

mercaptopurine................................................ .......... 15

metformin ................................................................ 22

methadone........................................................... ....... 26

methotrexate ................................................... ....... 3,15

methyldopa......................................... ..................... 17

methyleneblue.......................................................... 4

methylrosaniliniumchloride(gentianviolet) ..... 18

methylthioniniumchloride(methyleneblue)....... 4

metoclopramide ...................................................... 20

metronidazole ..................................................... 7,12

miconazole............................................................... 18

mifepristone ........................................................ ....... 25

misoprostol ......................................................... ....... 25

morphine...................... .......................................... 2,3

mumpsvaccine ....................................................... 24

naloxone ............................................................... ...... 4

nelfinavir(NFV)...................................................... 11

neomycinsulfate ..................................................... 18

neomycinsulfate+bacitracin................................ 18

neostigmine ........................................................... .. 24

nevirapine ........................................................ ........ 11

nevirapine(NVP).................................................... 11

niclosamide........... ..................................................... 5

nicotinamide............................................................ 28

nifedipine ......................................................... ........ 25

nifurtimox ................................................................ 14

nitrofurantoin ........................................................... . 7

nitrousoxide................................ .............................. 2

norethisterone ................................................... 21,22

norethisteroneenantate.......................................... 22

nystatin............................................................ ........... 9

ofloxacin.................................................... ................... 9

oralrehydrationsalts ....................................... 21,27

oxamniquine ....................................................... ......... 6

oxygen .............................................................. .......... 2

oxytocin........................................................ ............ 25

paminosalicylicacid ................................................... 9

paracetamol ......................................................... 3,14

paromomycin .......................................................... 12

penicillamine....................................................... ..... 3,4

pentamidine ......................................................... 12,13

permethrin .............................................................. . 19

pertussisvaccine ..................................................... 24

phenobarbital ........................................................... . 4

phenoxymethylpenicillin............ ............................. 6

phenytoin ................................................................... 5

phytomenadione..................................................... 16

pilocarpine ............................................................... 25

pneumococcalvaccine............................................24

podophyllumresin .................................................18

poliomyelitisvaccine .............................................. 24

polyvidoneiodine ................................................... 19

potassiumchloride............................................ 21,27

potassiumferrichexacyanoferrate(II) 2H20

(Prussianblue) ...................................................... 4

potassiumiodide ................................................... . 9,23

potassiumpermanganate.......................................18

praziquantel...............................................................5

prednisolone .................................................. 3,15,25

primaquine....................................... ........................ 13

procainamide................................................... ........... 17

procainebenzylpenicillin.........................................6

procarbazine.................................................... ........... 15

proguanil..................................................................13

promethazine................. ...................................... 2,20

propranolol ........................................................... ... 14

propylthiouracil ...................................................... 23

protaminesulfate .................................................... 16

Prussian blue .......................................................... ... 4

pyrantel ..................................................................... . 5

pyrazinamide.................................... ......................... 8

pyridostigmine .......................................................... . 24

pyridoxine................................................................28

pyrimethamine .................................................. 12,13

quinidine ......................................................... ........... 17

quinine......................................................................13

rabiesimmunoglobulin..........................................23

rabiesvaccine.............................................. ............. 24

ranitidine..................................................................20

retinol......................... ............................................... 28

ribavirin......................................................... ........... 11

riboflavin..................................................................28

rifampicin...................................................................8

rifampicin+isoniazid...............................................8

rifampicin+isoniazid+ethambutol.......................8

rifampicin+isoniazid+pyrazinamide ..................8

rifampicin+isoniazid+pyrazinamide+

ethambutol ............................................................ 8

ritonavir....................................................................11

rotavirusvaccine ................................................... .. 24

rubellavaccine............... .......................................... 24

salbutamol................ ................................................ 27

salicylicacid.............................................................18

saquinavir(SQV).....................................................11

seleniumsulfide .................................................... ..... 18

senna.........................................................................20

silversulfadiazine ................................................... 18

simvastatin...............................................................18

sodiumcalciumedetate............................................ 4

sodiumchloride ................................................ 21,27


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sodiumfluoride....................................................... 28

sodiumhydrogencarbonate ........................... 21,27

sodiumlactate ......................................................... 27

sodiumnitrite ............................................................ 4

sodiumnitroprusside................................................. 17

sodiumthiosulfate.............................................. 4,18

sodiumvalproate ................................................ 5,26

spectinomycin ........................................................... 7

spironolactone ......................................................... 19

stavudine................................................... ......... 10,11

stavudine(d4T)....................................................... 10

stavudine+lamivudine+nevirapine................... 11

streptokinase ....................................................... ....... 18

streptomycin........... ................................................... 8

sulfadiazine......................................................... ......... 7

sulfadoxine ....................................................... . 12,13

sulfadoxine+pyrimethamine ............................... 13

sulfamethoxazole ................................................ 7,13

sulfamethoxazole+trimethoprim .................... 7,13

sulfasalazine........................................................ ... 3,20

suraminsodium............................................... ...... 5,13

suxamethonium ...................................................... 24

tamoxifen .................................................. ................. 15

tenofovir............................................................. 10,11

testosterone ......................................................... ....... 21

tetanusvaccine ........................................................ 24

tetracaine ................................................................ .. 25

tetracycline...............................................................25

thiamine................................ .................................... 28

thiopental ............................................................ ....... 2

timolol.................................. ..................................... 25

triclabendazole .......................................................... 5

trimethoprim ............................................................. 7

tropicamide..............................................................19

tuberculin,purifiedproteinderivative(PPD).....23

typhoidvaccine ....................................................... 24

urea ...................................................... ..................... 19

valproicacid........................................................ . 5,26

vancomycin..................................................... ............. 8

varicellavaccine ...................................................... 24

vecuronium..................................................... ........... 24

verapamil ........................................................... 16,17

vinblastine........................................................ .......... 15

vincristine ....................................................... ........... 15

warfarin....................................................................16

waterforinjection ................................................... 27

yellowfevervaccine ...............................................24

zidovudine ........................................................ . 10,11

zidovudine(ZDVorAZT).....................................10

zidovudine+lamivudine....................................... 11

zidovudine+lamivudine+nevirapine................11

zincsulfate ................................................... ............ 21

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Essential Medicines WHO 15th edition

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