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Evaluation of the Diffusion Tension Imaging (DTI) Technique for Biometry and Morphology of the Fetal Corpus Callosum

Nadia Mordenfeld, MD MPH candidate

Noa Sanveta

Supervised by: Prof. Eldad Katorza


Introduction

• The Corpus Callosum (CC) is by far the largest fiber bundle in the human brain, interconnecting the two cerebral hemispheres.

• The fetal CC serves as a sensitive indicator for normal brain development and maturation.

Corpus Callosum


Introduction

• Earliest callosal fibers: 11-12 g.w.

• First systematic evaluation at the

mid-trimester ultrasound scan.

• Complete/ partial agenesis (dysgenesis) of the fetal CC may be associated with developmental delays and additional malformations.

Corpus Callosum


Introduction Corpus Callosum


Introduction

• Clinical standard evaluation of the CC: sonography (2D/ 3D US) and MRI on suspicious findings.

• Diffusion-Weighted Imaging (DWI) is a variant of conventional MRI based on the tissue water diffusion rate.

• Diffusion Tensor Imaging (DTI) is a specific type of modeling of the DWI datasets.

MRI, DTI & Tractography

New Possibilities in the research of white matter anatomy (e.g. CC)


Introduction MRI, DTI & Tractography


Introduction MRI, DTI & Tractography

T2-weighted sequence DTI


Aim Assessment of the Diffusion Tension Imaging (DTI) technique for biometry and morphology evaluation of the fetal corpus callosum (CC).


Methods Subjects & Measurements

• Cross-sectional study, based on fetal MRI examinations performed at the Sheba Medical Center, between 2017-2019.

• 2 study groups:

• MRI examinations indications included: suspected pathologic findings on US, maternal CMV infection, ventricles enlargement.

• Inclusion criteria: a singleton pregnancy, good quality sagittal DTI & T2-weighted sequences.

Normal CC CC malformations


T2-weighted sequence

Methods Statistical Analysis

DTI

Biometry

• Interclass Correlation Coefficient (ICC)

Morphology Evaluation

• Cohen’s Kappa Coefficient (k)

• Reliability analysis: Inter- and intra-observer variability – ICC

• Mean Differences: Bland-Altman plot will be presented for all ICCs.

Agreement between DTI & T2:


Methods Statistical Analysis


Summary - The corpus callosum (CC) is a sensitive

indicator for normal brain development.

- DTI is an MRI processing model which has opened new possibilities in the research and the clinical evaluation of white matter tracts like the CC.

- The aim of our study is to assess the DTI technique for biometry and morphology evaluation of the fetal CC.


סיכוםהוא מבנה המחבר בין שתי קאלוסוםקורפוס ה-

.ההמיספרות של המוח

נמצא כאינדיקטור להתפתחות תקינה של המוח - .בעוברים

-DTI המשתמשת , היא שיטת עיבוד חדשה יחסיתהקיימת ופותחת אפשרויות MRI-בטכנולוגיית ה

להערכה קלינית ומחקרית של מבנים בחומר הלבן .קאלוסוםהקורפוס ביניהם , שבמוח

DTI-להעריך את שיטת המטרת המחקר היא -לטובת הערכת הגודל והמורפולוגיה של

.העוברי קלוסוםהקורפוס


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Date post:	08-Aug-2020
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