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QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. Everything You Ever Wanted to Know About EphB4, Informatically- Speaking Ben Ferguson 7/30/07
| Date post: | 28-Jun-2015 |
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QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Everything You Ever Wanted to Know About EphB4,
Informatically-Speaking
Ben Ferguson7/30/07
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
• Erythropoietin-producing hepatoma• Largest family of RTKs; A and B
subclasses• Chr. 7q22, negative strand
• Previously known as HTK (Hepatocellular Transmembrane Kinase), Mdk2 (Mouse developmental kinase 2, Tyro11, Myk1
• 108.27 kDa
The Basics
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
The Basics
• Interacts with its ligand, ephrin-B2, on adjacent cells as heterodimer and heterotetramer; also with NMDA receptors, syndecan 3
• May also interact with Src, FAK, Rac, Rho, Ras, others
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
ttccagcgcagctcagcccctgcccggcccggcccgcccggctccgcgccgcagtctccctccctcccgctccgtccccgctcgggctcccaccatccccgcccgcgaggagagcactcggcccggcggcgcgagcagagccactccagggagggggggagaccgcgagcggccggctcagcccccgccacccggggcgggaccccgaggccccggagggaccccaactccagccacgtcttgctgcgcgcccgcccggcgcggccactgccagcacgctccgggcccgccgcccgcgcgcgcggcacagacgcggggccacacttggcgccgccgcccggtgccccgcacgctcgcatgggcccgcgctgagggccccgacgaggagtcccgcgcggagtatcggcgtccacccgcccagggagagtcagacctgggggggcgagggccccccaaactcagttcggatcctacccgagtgaggcggcgccatggagctccgggtgctgctctgctgggcttcgttggccgcagctttggaaggtgagtttccttgcgggggggggcgcaccccgtcactcctgggacctcccccccaacatctgggcctcggagtggaggggccggcctctgactacccctacccgggcactgcagtcccaaacacttcggaccgatagtgctggaacgggaggggggcggggaagaggcgcccgacgggtagtggagttttcttttgtttgggaaagagatggagtctggctacgacccgggacattcccctgcccgggctccccgaactctcactgctgattacatacgcccctggctgcctttcctttcctccctaccccactattcaaaactatctgcaaagtttctgtcccagtcccacctcccgccgtacatgagggaaggtttctggagaagcaacagcagacaaggcacaacttttcgtgctaggccctaaaacgacccccagcgccaattccttagcgatcacaccttgatcctccagttccacactcctgcaacaggatggcctcctttgcattcacacagcaaacccccaaaccgctctcccgcccactgctcctgcccctggtatagggtggctccttggtttctacaggctgcaccccatccctttaaatgcggtctagaccccggccccaggtgagtcccgggcttcccttgagacctaggagcgggtagaaactgacctacacagcccccaggtagaaactgacctacacagcccccacatcgccctaactaacccagtctatctcccacctcctggtctctccaagcatttctttggccatggatcgctgtccctcctggtcccctaaagggggagccaagagccctagaaactctcctgtgtccctaatgtcctttcagtgagctgccaacacccccctttctctgtctggtatgaaagtggttatggggcggtaggctatgagggactcccaaagggaaggattcagcggcgttagaaaaaccctctccccctggctgggcaggactgccctgggctggggatcaaaggctaggtgtggggttgggagtgaggggaggcttgcccagctcagagaacggagaagggggaacaaaaaccatgaacgaggggaagaggaaggccaaaggggtggaaaaaccacgaggacgaggtgtggtgagaaggaaagacgcaaagaggaaatggtgattgtgacacctattacctgagtgtttccaagcaccaggcctgtgctgagcgccttacaaatattaatttcacccatccagcaacgctaagggtggtgctattattgcccccatttttcagatgaggaggctggggcttagttaaggttaagtagtttatccaaggccctgtgccgcgaggaacagcgagaagtggaggccgaaagcgaaggagagatagtgactgtcagaaagagaaacggaggtggacagagagtggaggagagataggtgagagacatgcgaactgacagatcaaagcgtggctgcagctgagctgggacgcagaaagggagcctgcgcttgctctgggctgcggacagcccgaggcagagacagtgtgtaaattggagacaggaaaacactatcccggctggaacaatggagggtggagacggcagcctctatccacccccttcccagaacccgggcatcctgtccccagtgagcagggctgtctcttgccacccatggggaccttgcgcctctcacctcaggctggctggcttcccatctgacccctagctggaggacatcatttggtccccaggaagaggctgcctcacccaccctctttctcttctctcctgcagctcccatggggtgggagccaggtgttctggctcccctctccacccttcccagcgcccaatgccccccacattgccggcccccgaggggattcctgtaccctccctcctccactctccactgccaggggctgtgcagtttttcctaatccccccccttcctccagtgcctgtcccctcccccgatgatccgagccaagccaggtgtgttcacccctcccattcataccgccccccagaatctcctcccctctgccttcccataaccaaatccagatgtgaggcctcggcgggagcctgggaaccctagcatcccgacctccagtgcttcctgatcagggcactcgtggggagggaggtactgggatgggggccagggctatgccccaggcacggagcgctcccttcaaggagggaaggacggggtgtttggtctgaaagcagagaggggtcttggacagggaatgaaattgtggggtagagaggctgattctgggacttaggggaggaaacgtggaggctgagacaagaggttcccctcccacaccagcagcctctgctcgtgggggtcaggaccagggcgcagctctcattttaaccctttctgagctgccgccccttctccccgtacattttgatctccctccctcctccagggaggcctagatctggggtatcccaagggagccccatgcctaccagatgttgggggtggggttggcacttagcagaagaggccagaaatcaggcgggtgcagagggcagggcttgctcccctcttggccccccaactcctctagctcagagctaagaggatccacctgcctcggttcccagggatctggtcttcctgacctccctcccccaccccaggcactgactctgtctctctgtctgtctcagagaccctgctgaacacaaaattggaaactgctgatctgaagtgggtgacattccctcaggtggacgggcaggtgagagctgcacccaggagctggagctctggagggaaactgagggaggagagggcgcctgtgccgcctgctttctgtgtgccactcctctcccctgtccccccagatgacagcagccccagcagtgtcgtctgagcccttctcagaggcgccctcctcgcagtaccagcagcccccctttctcagtccctctcactttataggattcaccccatgcagccctctccctggcggctccccagcccccttgctgacctccttctctgcacagtgggaggaactgagcggcctggatgaggaacagcacagcgtgcgcacctacgaagtgtgtgacgtgcagcgtgccccgggccaggcccactggcttcgcacaggttgggtcccacggcggggcgccgtccacgtgtacgccacgctgcgcttcaccatgctcgagtgcctgtccctgcctcgggctgggcgctcctgcaaggagaccttcaccgtcttctactatgagagcgatgcggacacggccacggccctcacgccagcctggatggagaacccctacatcaaggtacctgggtgcccccagggctcagccacagccaaggtgggattccagccagcaggcccgtggcctggagggcagccgatgtagttgcgaggcctctggcccgcgcgctgggggctggaagcaggaggcttaggtctggggagggaagggggtgatcttctgggcggaggagcagaatatacgggggctgcctggcccggcccccagggaggcccaagggtcaggcttctcctccagtcacctcaaccaccctaccccactgtgctccagccacactgagtttctcccattccctgactgcacctggctggtttccagctcaagactttgcagcggtgatgtctccacctgggggcctctctgcctctcacacccctacttgtcttcggagttccagctcccgagatcttgcctgtgccaccttggctgactctctcctccctacaatcctgcatacctctgtccacctgcctgtctcggcactcattttactttatttatttttcttttatatctatatttttaaagcggggtcttctacgttacccaggctggtctctaactcctgggctcaagagatttctcccacctcggcctcctaaagtgctgggattataggcatgaggcactacgcccggcctcatggtactttataacttccccaggattcattcatcgctgtctccttgactctgaggtcaaggcctggcatggcgtcagtgtcagtaaatgtttgtagaacgagtgaataaaaagggggagaggtgcaggccagaggccgggcatatcgcaggagctttgcaaggctgaatggacagtgtgggggcctgcagaaagtgtgccctggggaaggtggagggaagattctggaacgggaaccaaggaggtccgggagggtgagctgggaagaacacaacagtccgctgggtcctcagggagtggggacagcagcggtgtgcctcccccccgccggcaggtggacacggtggccgcggagcatctcacccggaagcgccctggggccgaggccaccgggaaggtgaatgtcaagacgctgcgtctgggaccgctcagcaaggctggcttctacctggccttccaggaccagggtgcctgcatggc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ttccugcgcugctcugcccctgcccggcccggcccgcccggctccgcgccgcugtctccctccctcccgctccgtccccgctcgggctcccuccutccccgcccgcguggugugcuctcggcccggcggcgcgugcugugccuctccuggguggggggguguccgcgugcggccggctcugcccccgccucccggggcggguccccguggccccgguggguccccuuctccugccucgtcttgctgcgcgcccgcccggcgcggccuctgccugcucgctccgggcccgccgcccgcgcgcgcggcucugucgcggggccucucttggcgccgccgcccggtgccccgcucgctcgcutgggcccgcgctgugggccccgucguggugtcccgcgcggugtutcggcgtccucccgcccugggugugtcugucctgggggggcgugggccccccuuuctcugttcggutcctucccgugtguggcggcgccutggugctccgggtgctgctctgctgggcttcgttggccgcugctttgguuguguccctgctguucucuuuuttgguuuctgctgutctguugtgggtgucuttccctcuggtggucgggcugtgggugguuctgugcggcctggutgugguucugcucugcgtgcgcucctucguugtgtgtgucgtgcugcgtgccccgggccuggcccuctggcttcgcucuggttgggtcccucggcggggcgccgtccucgtgtucgccucgctgcgcttcuccutgctcgugtgcctgtccctgcctcgggctgggcgctcctgcuugguguccttcuccgtcttctuctutgugugcgutgcggucucggccucggccctcucgccugcctggutgguguucccctucutcuuggtggucucggtggccgcggugcutctcucccgguugcgccctggggccguggccuccggguuggtguutgtcuugucgctgcgtctggguccgctcugcuuggctggcttctucctggccttccugguccugggtgcctgcutggccctgctutccctgcucctcttctucuuuuugtgcgcccugctguctgtguucctguctcguttcccgguguctgtgcctcgggugctggttgtgcccgtggccggtugctgcgtggtggutgccgtccccgcccctggccccugccccugcctctuctgccgtguggutggccugtgggccguucugccggtcucgggctgcugctgtgctccggggttcguggcugctgugggguucuccuugtgccgugcctgtgcccugggcuccttcuugcccctgtcugguguugggtcctgccugccutgcccugccuutugccuctctuucuccuttggutcugccgtctgccugtgccgcgtcgggtucttccgggcucgcucugucccccggggtgcuccctgcuccucccctccttcggctccgcggugcgtggtttcccgcctguucggctcctccctgcucctgguutggugtgcccccctggugtctggtggccguguggucctcucctucgccctccgctgccgggugtgccgucccgguggctcctgtgcgccctgcgggggugucctgucttttguccccggcccccgggucctggtggugccctgggtggtggttcgugggctucgtcctgucttcucctutucctttguggtcuctgcuttguucggggtutcctccttugccucggggcccgtcccutttgugcctgtcuutgtcuccuctguccguguggtucctcctgcugtgtctgucutccgggtgucgcggtcctcucccugcugcttgugcctggcctgggctgttccccgggcucccugtggggctgtgctgguctucguggtcuuutuccutguguugggcgccgugggtcccugcugcgtgcggttcctguugucgtcuguuuuccgggcugugctgcgggggctguugcggggugccugctucctggtgcuggtucgggcgcgctctguggccggctucgggcccttcggccugguucutcucugccugucccuuctggutgugugcgugggctggcgggugcugctggccctguttgcgggcucggcugtcgtgggtgtggtcctggtcctggtggtcuttgtggtcgcugttctctgcctcugguugcugugcuutggguguguugcuguututtcggucuuucucggucugtutctcutcggucutggtuctuuggtctucutcguccccttcucttutguuguccctuutguggctgtguggguutttgcuuuugugutcgutgtctcctucgtcuuguttguuguggtguttggtgcuggtgugtttggcguggtgtgccgggggcggctcuuggccccuggguuguuggugugctgtgtggcuutcuuguccctguugggtggctucucggugcggcugcggcgtgugtttctgugcguggcctccutcutgggccugttcgugcuccccuututcutccgcctggugggcgtggtcuccuucugcutgcccgtcutguttctcucugugttcutgguguucggcgccctgguctccttcctgcggctuuucgucggucugttcucugtcutccugctcgtgggcutgctgcggggcutcgcctcgggcutgcggtuccttgccgugutgugctucgtccuccgugucctggctgctcgcuucutcctugtcuucugcuucctcgtctgcuuugtgtctguctttggcctttcccguttcctggugguguuctcttccgutcccucctucucgugctccctgggugguuuguttcccutccgutgguctgccccgguggccuttgccttccgguugttcucttccgccugtgutgcctggugttucggguttgtgutgtggguggtgutgtcutttgggguguggccgtuctgggucutgugcuutcuggucgtgutcuutgccuttguucugguctuccggctgcccccgcccccuguctgtcccucctccctccuccugctcutgctgguctgttggcuguuuguccgguutgcccggccccgcttcccccuggtggtcugcgccctggucuugutgutccgguuccccgccugcctcuuuutcgtggcccggguguutggcggggcctcucuccctctcctgguccugcggcugcctcuctuctcugcttttggctctgtgggcgugtggcttcgggccutcuuuutggguugutucguuguuugtttcgcugccgctggctttggctccttcgugctggtcugccugutctctgctguggucctgctccguutcggugtcuctctggcgggucuccuguuguuuutcttggccugtgtccugcucutguugtcccuggccuugccggguuccccgggtgggucuggugguccggccccgcugtuctgucctgcugguuctccccuccccugggucuccgcctccccuttttccggggcugugtgggguctcucuguggcccccugccctgtgccccgctgguttgcuctttgugcccgtggggtguggugttggcuutttggugugucuggutttgggggttctgccutuutuggugggguuuutcuccccccugccucctcgggguuctccuguccuugggtgugggcgcctttccctcugguctgggtgtguccugugguuuugguugtgcccuucutctcccugcctccccuggtgcccccctcuccttgutgggtgcgttcccgcuguccuuugugugtgtguctcccttgccugctccugugtgggggggctgtcccugggggcuuguuggggtgtcugggcccugtgucuuuutcuttggggtttgtugtcccuucttgctgctgtcuccuccuuuctcuutcutttttttcccttgtuuutgcccctcccccugctgctgccttcututtguuggtttttgugttttgtttttggtcttuutttttctccccgttccctttttgtttcttcgttttgtttttctuccgtccttgtcutuuctttgtgttgguggguucctgtttcuctutggcctcctttgcccuugttguuucuggggcccutcutcutgtctgtttccuguucugtgccttggtcutcccucutccccgguccccgcctgggucccccuugctgtgtcctutguuggggtgtggggtguggtugtguuuugggcggtugttggtggtgguucccuguuucggucgccggtgcttgguggggttcttuuuttututttuuuuuugtuuctttttgtutuuutuuuuguuuutgggucgtgtcccugctccuggggtuuuuuuuuuuuuuuuuuu
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
MELRVLLCWASLAAALEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEVCDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDADTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCREDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSAVCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALRCRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPVPFEPVNVTTDREVPPAVSDIRVTRSSPSSLWAVPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLALIAGTAVVGVVLVLVVIVVAVLCLRKQSNGREAEYSDKHGQYLIGHGTKVYIDPFTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLDQRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKKILASVQHMKSQAKPGTPGGTGGPAPQY
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Isoform A: full length
Isoform B: missing 52 residues near carboxy terminus (linker and SAM regions)
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Science Primer: http://www.ncbi.nlm.nih.gov/About/primer
Human Protein Reference Database: http://www.hprd.org
