Excellent performance - Chromatography › wpadmin › uploads › application...Excellent...

Excellent performance

Persistence and highest quality

Wide range of product line

Abundant accumulation of technologyand experience

spherical and sharp particle size distribution

offeres packing materials and packed columns,under strict quality control

MCI GEL™ has been designed based on technology of the world famous Diaion™ and Sepabeads™,

specialized in polymeric packing materials includingfrom analytical to preparative use,

for ion exchange, reversed-phase mode

for more than 50 years, MCI GEL™ has been used for HPLC applications

Sugars・Sugar alcohols・Organic acids《CK08,06 series》Examples of peak retention time 《CK08E series》Oligosaccharides 《CK04S・CK04SS・CK02A・CK02AS》Amino acids《CK10U》Sugars・Organic acids 《CA08F》Nucleic acids etc. ・Sugars・Human urine 《CDR10》

Bioseparation columnsIon exchange chromatography column《XtalSpeedTM》

Rituxan《XtalSpeedTM》Column list and materials［Applications］

Size exclusion chromatography columnsAqueous size exclusion columns 《CQP series》

Column list and materials［Applications］Calibration curves 《CQP series》

Proteins・Water soluble polymers 《CQP series》

Separation mechanism of CHP seriesPolymeric partition chromatography columns and materials MCI GELTM CHP series

Solid phase extraction sorbents

Column listColumn durability[Applications] Organic compounds・Insulin・Peptide 《CHP column series》

Polymeric chromatography materials 《CHP material series》Chromatography material list[Applications] Organic compounds 《CHP material series》

Synthetic adsorbents and reversed-phase material listChelating type list

Column selection guide

Ion exchange columns and materials

Ion chromatography columns and materials

Bioseparation columns and materials

Analytical and preparative chromatography columns and materials for pharmaceutical applications

Chiral separation columns

MCI GEL™ material list

MCI GEL™ column list

Compounds index

Column list and materials［Applications］

Features

Column list and materials［Applications］Cations 《SCK01》

Cations 《CHK45》Anions 《SCA04》

Separation mechanism of CRS series

Separation conditions for various amino acids[Applications] Optical isomers 《CRS10W・CRS15W》

5

1

6

10

9

8

5

4

3

2 5～22

28～32

567～121314～1617～1819～2021～22

USP list 3

2829～30293031～3231313232

3333343536～48

606060

49～564950～53

5455～5859

33～53

54～59

61～62

SPE sorbent series7 60

63～66

67～75

23～2723～2424～252526～27

3～4

1 2

�R�e�v�e�r�s�e�d�-� �P�h�a�s�e

�I�o�n� �E�x�c�h�a�n�g�e


�S�i�z�e� �E�x�c�l�u�s�i�o�n

�I�o�n� �E�x�c�l�u�s�i�o�n

�I�o�n�C�h�r�o�m�a�t�o�g�r�a�p�h�y

�S�i�z�e� �E�x�c�l�u�s�i�o�n

�M�.�W�.�<�2�,�0�0�0

�M�.�W�.�>�2�,�0�0�0

�W�a�t�e�r�S�o�l�u�b�l�e

�O�r�g�a�n�i�c�S�o�l�v�e�n�t�S�o�l�u�b�l�e

�S�a�m�p�l�e

�L�i�g�a�n�d� �E�x�c�h�a�n�g�e


�M�i�x� �m�o�d�e

�N�o�r�m�a�l� � �P�h�a�s�e

�M�i�x� �m�o�d�e

�I�o�n� �E�x�c�l�u�s�i�o�n

33～53

14～16

14～16

31～32

17～ 1819～22

21～22

31～32

29～31

33～53

23～27

7～1354～59

34,45～48

33～53

33～53

23～25

33～53

33～53

34,45,48

7,11～12

CK02A CK02AS

CK04S CK04SS

CQP06

CK10U

CDR10

CA08F CDR10

CQP10 CQP30

XtalSpeedTM

CMG20CHPODCHP20 CHP07

SCA04

CMG20 CHPOD

SCK01CHK45

CMG20CHPODCHP20CHP07

CHK40CHK45

CHP20 CMG20CHP07

CK08E SeriesCRS10W CRS15W

CHK40CHK45

CK08EH

Column selection guide

�N�a�t�u�r�e� �o�f� �s�a�m�p�l�e �S�e�p�a�r�a�t�i�o�n�m�o�d�e

�M�C�I� �G�E�L�™

�c�o�l�u�m�n �p�H� �r�a�n�g�e �A�p�p�l�i�c�a�t�i�o�n�s �P�a�g�e�s

1 Column selection guide

(α�-�a�m�i�n�o� �a�c�i�d�s・� � � � α�-�h�y�d�r�o�x�y� �c�a�r�b�o�x�y�l�i�c� �a�c�i�d�s�)

�O�r�g�a�n�i�c� �C�o�m�p�o�u�n�d�s



Full range

Full range

Full range

Full range

Full range

�P�e�p�t�i�d�e�s

1 ～ 7

6 ～ 7

6 ～ 7

2 ～12

1 ～141 ～13

1 ～13

2 ～12

2 ～12

2 ～12

5 ～ 7

2 ～12

3 ～ 71.5～12

2 ～12

1 ～ 7

�O�l�i�g�o�s�a�c�c�a�r�i�d�e�s

�O�l�i�g�o�s�a�c�c�a�r�i�d�e�s

�A�m�i�n�o� �a�c�i�d�s�O�r�g�a�n�i�c� �a�c�i�d�s�S�a�c�c�h�a�r�r�i�d�e�s

�N�u�c�l�e�o�t�i�d�e�s

�P�r�o�t�e�i�n�s�,�B�i�o�p�o�l�y�m�e�r�s� �W�a�t�e�r� �s�o�l�u�b�l�e� �p�o�l�y�m�e�r�s

�P�r�o�t�e�i�n�s�,�A�n�t�i�b�o�d�y

�P�r�o�t�e�i�n�s�,�P�e�p�t�i�d�e�s

�P�r�o�t�e�i�n�s�,�P�e�p�t�i�d�e�s

�A�n�i�o�n�s

�A�m�i�n�o� �a�c�i�d�s�,� �N�u�c�l�e�t�i�d�e

�O�p�t�i�c�a�l� �i�s�o�m�e�r�s�S�a�c�c�h�a�r�r�i�d�e�s

�C�a�t�i�o�n�s

�O�r�g�a�n�i�c� �C�o�m�p�o�u�n�d�s�p�e�p�t�i�d�e�O�r�g�a�n�i�c� �C�o�m�p�o�u�n�d�s�p�e�p�t�i�d�e

�O�r�g�a�n�i�c� �a�d�i�d�s

●USP LISTING OF MCI GELTM

●Product list by particle size and separation mode

USP Code

L17

L19

L21

L25

L31

L32

L37

L38

L39

L58

CK08EH

CK08EC

CHP20/C04CHP20/C10

CQP06

SCA04

CRS10WCRS15W

CQP30

CQP10CQP30CMG20/C04CMG20/C10CK08SCK08ECK04SCK02A

PACKING MCI GELTM

Column Page

Strong cation-exchange resin consisting of sulfonated cross-linked styrene-divinylbenzene copolymer in the hydrogen form, 6 to 12 µm in diameter

Strong cation-exchange resin consisting of sulfonated cross-linked styrene-divinylbenzene copolymer in the calcium form, 5 – 15 µm in diameter

A rigid, spherical styrene-divinylbenzene copolymer, 3 to 30 µm in diameter

Packing having the capacity to separate compounds with a molecular weight range from 100-5000 (as determined by polyethylene oxide), applied to neutral, anionic, and cationic water-soluble polymers. A polymethacrylate resin base, cross-linked with polyhydroxylated ether (surface contained some residual carboxyl functional groups) was found suitable

A hydroxide-selective, strong anion-exchange resin-quaternary amine bonded on latex particles attached to a core of 8.5-µm macroporous particles having a pore size of 2000 Ǻ units and consisting of ethylvinylbenzene cross-linked with 55% divinylbenzene

A chiral ligand-exchange resin packing-L-proline copper complex covalently bonded to irregularly shaped silica particles, 5 to 10 µm in diameter

Packing having the capacity to separate proteins by molecular size over a range of 2,000 to 40,000 Da. It is a polymethacrylate gel

A methacrylate-based size-exclusion packing for water-soluble samples

A hydrophilic polyhydroxymethacrylate gel of totally porous spherical resin

Strong cation-exchange resin consisting of sulfonated cross-linked styrene-divinylbenzene copolymer in the sodium form, about 6 to 30 µm diameter

5

CK CK

CDR10

CQA_PCQK_P

XtalSpeedTM

CHK40CHK45

CK CKCA CA CA CA

CK

10 30 50 150

Analytical Preparative

CHK45SCA

SCK

CQP

CRS

CHP20/P20 CHP20/P30 CHP20/P50 CHP20/P120CHP20/P70CHP20/C04 CHP20/C10

CHPOD/P30CHPOD/C04

CMG20/C04 CMG20/C10CMG20/P10 CMG20/P30 CMG20/P150

CHP85/P120CHP87/P120

CHP07/C04 CHP07/C10 CHP07/P120

CHP50/P20 CHP50/P30CSP50/P10

Particle size［μm］Separation

mode

Ion exchange

Ion chromatography

Normal phase

Size exclusion

Mix mode

Ligand exchange

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

10

1

2

4

5

6

8

9

10

1

2

3

5

6

8

9

10

1

2

3

4

6

8

9

10

1

2

3

4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum

n listChiral separationcolum

ns

Analytical and preparative chromatography columns and materials for pharm

aceutical applicationsCom

pounds indexMCI GEL™ material list

Bioseparation columns

and materials

Ion chromatography

columns and m

aterialsIon exchange colum

ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials

Ion exchange columns

and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


nsAnalytical and preparative chromatography columns and materials for pharm




and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list

Chiral separationcolum

ns





and materials

SPE sorbent seriesIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series


aceutical applicationsBioseparation colum

ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series


nsSPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

SPE sorbent seriesChiral separationcolum

nsMCI GEL™ material list

MCI GEL™ colum

n listBioseparation colum

ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide



aceutical applications


Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


ns


aceutical applicationsMCI GEL™ material list

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11

カラム選択の手引き

イオン交換クロマトグラフィー用

充填カラム及び充填剤

イオンクロマトグラフィー用


生体高分子分離用


医薬精密精製用充填カラム

及び充填剤

アミノ酸DL分離用

充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧

分離例化合物リスト

7

固相吸着剤

3 4

●Description of a gel type ion exchange column

MCI GEL™ CK08ECfor HPLC use

Cation＝KAnion＝A

DVB%

Counter ion

Particle size（mode）

no letter＝Na+, C＝Ca2+S＝Ag+, H＝H+

A＝20μm, S＝11μmE＝9μm, F＝7μm,U＝5μm

●Note ; Pre-column and guard column

●MCI GEL™ columns for HPLC

Please consider using a guard column concerning purity of injection sample. Guard columns, are listed in the end of this catalog, should be selected in accordance with a main column.

As for analysis of amino acids by MCI GEL™ CK10U, MCI GEL™ AFR2-PC is recom-mended as a pre-column. The AFR2-PC column is very effective to stabilize base line because it can trap ammonium ion in eluent. A peak caused of the ammonium ion may disturb base line stability.

2.

1.

Typical usageDescription

Product nameColumn

dimensionsI.D�L[mm]

10

8

8

8

8

8

4

4

2

2

8

Highporous

5

11

9

9

9

9

11

11

20

20

7

7

Na+

Na+

Na+

Ca2+

Ag+

H+

Na+

Ag+

Na+

Ag+

SO24-

AcO-

L58

6 11Ca+

L58

L19

L17

L58

L58

6�120

8�500

7.8�300

7.8�300

8�300

7.8�300

8.0�300

8.0�300

8.0�300

10�200

10�200

20�250

20�250

4.6�250

4.6�250

MCI GEL™ CK04S

MCI GEL™ CK04SS

MCI GEL™ CK02A

MCI GEL™ CK02AS

MCI GEL™ CA08F

MCI GEL™ CDR10

MCI GEL™ CK10U

MCI GEL™ CK08S

8�500MCI GEL™ CK06SC

MCI GEL™ CK08E

MCI GEL™ CK08EC

MCI GEL™ CK08ES

MCI GEL™ CK08EH

MCI GEL ™Anion

exchange columnsM

CI G

EL™ C

ation exchange columns

Aminoacid

Monosaccharide

Oligo-saccharide

Carboxylicacid

Amine Physiologicalfluid

Packing materialCross

linkage[%]

Particlesize[μm]

Counterion

USP

●Packing materials　 Packing materials are available. Please look at P.64 and P.65.

Features

Ion exchange columns and materials

�M�C�I� �G�E�L�™� �s�p�e�c�i�a�l�i�z�e�s� �i�n� �p�o�l�y�m�e�r� �b�a�s�e�d� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s�.� �S�p�e�c�i�f�i�c�a�l�l�y�,� �p�o�l�y�s�t�y�r�e�n�e� �p�o�l�y�m�e�r� �b�a�s�e�d� �i�o�n� �e�x�c�h�a�n�g�e� �r�e�s�i�n�s� �a�r�e� �d�e�r�i�v�e�d� �f�r�o�m� �o�v�e�r� �5�0� �y�e�a�r�s� �o�f� �m�a�n�u�f�a�c�t�u�r�i�n�g� �e�x�p�e�r�i�e�n�c�e� �o�f� �D�i�a�i�o�n�™� �p�r�o�d�u�c�t� �l�i�n�e�.� �M�C�I� �G�E�L�™� �i�o�n� �e�x�c�h�a�n�g�e� �r�e�s�i�n�s� �f�o�r� �H�P�L�C� �h�a�v�e� �b�e�e�n� �d�e�v�e�l�o�p�e�d� �w�i�t�h� �t�h�e� �s�a�m�e� �a�t�t�e�n�t�i�o�n� �t�o� �p�e�r�f�o�r�m�a�n�c�e� �a�n�d� �q�u�a�l�i�t�y�.� �F�o�r� �s�e�v�e�r�a�l� �d�e�c�a�d�e�s�,� �M�i�t�s�u�b�i�s�h�i� �C�h�e�m�i�c�a�l� �h�a�s� �b�e�e�n� �p�r�o�v�i�d�i�n�g� �M�C�I� �G�E�L�™� �i�o�n� �e�x�c�h�a�n�g�e� �c�o�l�u�m�n�s� �a�r�e� �o�f�f�e�r�e�d� �i�n� �a� �v�a�r�i�e�t�y� �o�f� �c�h�e�m�i�s�t�r�i�e�s�,� �p�a�r�t�i�c�l�e� �s�i�z�e�s� �a�n�d� �c�o�u�n�t�e�r� �i�o�n�s� �t�o� �s�u�p�p�o�r�t� �a� �b�r�o�a�d� �r�a�n�g�e� �o�f� �a�p�p�l�i�c�a�t�i�o�n�s�.

�I�o�n� �e�x�c�h�a�n�g�e� �r�e�s�i�n�s� �a�r�e� �g�e�n�e�r�a�l�l�y� �u�s�e�d� �f�o�r� �a�n�a�l�y�s�i�s� �o�f� �a�m�i�n�o� �a�c�i�d�s�,� �s�u�g�a�r�s�,� �o�r�g�a�n�i�c� �a�c�i�d�s� �a�n�d� �a�m�i�n�e�s�,� �e�t�c�.� �M�C�I� �G�E�L�™� �c�u�s�t�o�m� �p�r�e�-�p�a�c�k�e�d� �c�o�l�u�m�n�s� �a�r�e� �s�p�e�c�i�f�i�c�a�l�l�y� �d�e�s�i�g�n�e�d� �f�o�r� �e�a�c�h� �a�p�p�l�i�c�a�t�i�o�n� �u�s�i�n�g� �t�h�e� �m�o�s�t� �a�p�p�r�o�p�r�i�a�t�e� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l� �a�m�o�n�g� �o�u�r� �p�r�o�d�u�c�t� �l�i�n�e� �a�n�d� �u�s�i�n�g� �t�h�e� �m�o�s�t� �s�u�i�t�a�b�l�e� �c�o�l�u�m�n� �d�i�m�e�n�s�i�o�n�s�.�T�y�p�i�c�a�l� �a�p�p�l�i�c�a�t�i�o�n� �f�o�r� �e�a�c�h� �c�o�l�u�m�n� �i�s� �s�h�o�w�n� �i�n� �t�h�i�s� �c�a�t�a�l�o�g�.� �T�h�e�s�e� �d�a�t�a� �w�i�l�l� �s�u�g�g�e�s�t� �a�n� �a�p�p�r�o�p�r�i�a�t�e� �c�o�l�u�m�n�.

Mitsubishi Chemical Ion Exchange Resins

1. Variety of products

2. Persistence of high quality, excellent separation performance

3. Accumulation of abundant knowledge and experience of applications

●Chemical structure of ion exchange resin〈Strongly acidic cation exchange resin〉〈Strongly basic anion exchange resin〉

MCI GEL™ CK series○Cation exchange resins

○Anion exchange resinsMCI GEL™ CA series

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2 Ion exchange columns and materials

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充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

5 6

Cation exchange columnsapplications; sugars, carboxylic acids, (poly)alcohols, etc.CK08,06 series Cation exchange columnsapplications; sugars, carboxylic acids, (poly)alcohols, etc.

2

CK08EC 8×300, 7.8×300 CK08EH 8×300, 7.8×300

Application data of CK08ECFig. 2-1 Sugars Fig. 2-2 Apple juice

●Column list

MCI GEL™ column Counter ion

MCI GEL™ CK08SMCI GEL™ CK08E Na+

MCI GEL™ CK08EC Ca2+

MCI GEL™ CK08ES Ag+

MCI GEL™ CK06SC Ca2+

USP

L58

L17

L19

Application areas

General sugar separation columns

The most general sugar separation columnHighly recommended for fructose and glucoseThis column conforms to US Pharmacopeia.

Gel permeation chromatographic effect

Use for analysis of mono-saccharides and disaccharides.

MCI GEL™ CK08EH H+ Organic acids with H3PO4 eluent; sugars with distilled water eluent

：MCI GEL™ CK08EC　8mm I.D.×300mm：H2O：0.6：75℃：RI

Fig. 2-3 Lactulose syrup

min.0 10 20 30 min. min.0 10 20 30 0 4 8 12 16 20 24 28

Sorb

itol

Rib

ose

Fruc

tose

Fruc

tose

Salic

inM

anni

tol

Adon

itol

mes

o-Er

ythr

itol

Man

nose

Glu

cose

Lact

ose

Gen

tiobi

ose

Stac

hyos

e

Xylit

ol

Glu

cose

Sucr

ose

Lact

ose

Lact

ulos

e

Gal

acto

seConditionsColumn

EluentFlow rateColumn temp.Detection

Application data of CK08EC

Fig. 2-4 Sports drink A

：MCI GEL™ CK08EC　8mm I.D.×300mm：H2O：0.6：75℃：RI

Fig. 2-5 Sports drink B Fig. 2-6 Honey

Fig. 2-7 Jam Fig. 2-8 Sugars/Alcohols

Sucr

ose

Sucr

ose

Glu

cose

Glu

cose

Glu

cose

Fruc

tose

Fruc

tose

Fruc

tose

Dp

3

Dp

2

Dp

2

min.0 10 20 min.0 10 20 min.0 10 20

Glu

cose

Glu

cose

Fruc

tose Fr

ucto

se

Ethy

l alc

ohol

Man

nito

l

min.0 10 20 min.0 10 20Er

ythr

itol

Gly

cero

l

ConditionsColumn


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充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

7 8


D-(+)-Glucose D-(-)-Fructose meso-ErythritolGlycerolEthanolD-Mannitol

Results:

Pressure: 28Bar (Including system pressure)

Rt RsAsTPN11.39 14.39 16.59 17.31 18.18 18.83

2085 2597

16899 19051 37357 12885

-2.892.661.402.121.33

1.07 0.97 0.84 0.95 0.80 1.00

D-(+)-Glucose D-(-)-Fructose meso-ErythritolGlycerolEthanolD-Mannitol

Results:


Rt RsAsTPN10.2513.3715.6316.3216.7317.99

15092210

15833216083552510387

-2.932.781.501.142.43

1.120.980.900.951.690.96

Stachyose hydrateβ-Gentiobioseα-Lactose monohydrateD-(+)-GlucoseD-(+)-MannoseD-(-)-FructoseRibitol (Adonitol)meso-ErythritolD-MannitolD-(-)-SalicinXylitolD-(-)-Ribose

123456789

101112

Results:


Rt RsAsTPN8.259.139.83

11.2712.9014.3215.7816.5018.7319.6922.6623.75

511155043024200233502713

1541017734130444104

139652278

-1.861.221.771.761.471.851.433.901.083.090.86

1.040.971.191.091.011.010.840.990.871.350.882.09

Stachyose hydrateβ-Gentiobioseα-Lactose monohydrateD-(+)-GlucoseD-(+)-MannoseD-(-)-FructoseRibitol (Adonitol)meso-ErythritolD-(-)-SalicinD-MannitolXylitolD-(-)-Ribose

123456789

101112

Results:


Rt RsAsTPN7.218.028.76

10.2311.7813.2714.7615.5116.8617.8821.9022.87

424343972249144128302188

13744160053594

12043132352381

-1.781.281.731.631.511.861.501.791.235.720.86

1.071.011.141.061.031.000.921.010.881.070.943.00

D-(+

)-Glu

cose

D-(-

)-Fru

ctos

e

Etha

nol

Gly

cero

l

mes

o-Er

ythr

itol

D-M

anni

tol

D-(+

)-Glu

cose

D-(-

)-Fru

ctos

e

Etha

nolGly

cero

lm

eso-

Eryt

hrito

l

D-M

anni

tol

0 5 10 15 min20 25 300 5 10 15 min20 25 30

1 2

3

4 5

6

7

8

9

10

11

12

12

3

45

6

7

8

9

10

11

12

0 5 10 15 min20 25 30 0 5 10 15 min20 25 30

① MCI GELTM CK08EC (7.8�300mm) ② Competitor’s Column

① MCI GELTM CK08EC (7.8�300mm) ② Competitor’s Column

Fig. 2-9 Sugars／Alcoles（Comparison with competitor’s column）

Fig. 2-10 Sugars（Comparison with competitor’s column）

：7.8x 300 mmI.D. (MCI GEL™ CK08EC / Competitor’s Column )

：20μL：40mmol/ml　each

：Milli Q water：0.6：75 ℃

ConditionsColumnEluent Flow rateTemperatureSample ConcInjection

：7.8x 300 mmI.D. (MCI GEL™ CK08EC / Competitor’s Column )

：20μL：40mmol/ml　each

：Milli Q water：0.6：75 ℃

ConditionsColumnEluent Flow rateTemperatureSample ConcInjection

RI (

mV)

RI (

mV)

RI (

mV)

RI (

mV)


Application data of CK08E

Fig. 2-12 Maltose syrup powder

① Maltose syrup powder ② Mixture

Fig. 2-11 Analysis of galoctose impurity

ConditionsColumn EluentFlow rateTempSample

Injection

：MCI GEL™ CK08E 7.8mm I.D.×300mm：Milli Q water：0.4：50℃：

：5μl.

1.Maltotoriose2.Maltose3.Glucose

：MCI GEL™ CK08EC 7.8mm I.D.×300mm：Milli Q water：0.6：85℃

ConditionsColumn EluentFlow rateTemp

2016128 min40 2016128 min40

① Galactose / Fructose = 0.1 / 99.9 ② Galactose / Sucrose = 0.1 / 99.9

2016128 min40

Fructose

Galactose

2016128 min40

Sucrose

Galactose

1.M

alto

torio

se 1.M

alto

torio

se

2.M

alto

se

2.M

alto

se

3.G

luco

se

3.G

luco

se

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及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

9 10

Application data of CK08EH

Tric

hlor

oace

tic a

cid

4 20 min.8 12 16

Dic

hlor

oace

tic a

cid

Acet

ic a

cid

Chl

oroa

cetic

aci

d

Gly

colic

aci

d

10 20 min.

Dic

hlor

oace

tic a

cid

Acet

ic a

cid

Chl

oroa

cetic

aci

d

Ethy

lene

gly

col

Die

thyl

ene

glyc

olTr

ieth

ylen

e gl

ycol

10 20 min.

Fig. 2-19 Lactose

Lact

ose

Lact

ulos

e

Gal

acto

se

Fig. 2-17 Poly alcohols

：MCI GEL™ CK08EH　8mm I.D.×300mm：1% H3PO4

：0.6：25℃：RI

ConditionsColumn


：MCI GEL™ CK06SC　8mm I.D.×500mm：H2O ：1.0：75℃：RI：20μL

ConditionsColumn

EluentFlow rateColumn temp.DetectionInjection volume


：0.6：ambient：210nm

Fig. 2-18 Carboxylic acids

ConditionsColumn


Fig. 2-16 Chloroacetic acids


：0.6：45℃：210nm

ConditionsColumn


Application data of CK06SC

4 8 12

Application data of CK08EH

Fig. 2-13 Carboxylic acids Fig. 2-14 Amino sugars

40

Acet

ic a

cid

Form

ic a

cid

Lact

ic a

cid

Gly

colic

aci

dM

alon

ic a

cid

Mal

ic a

cid

Tarta

ric a

cid

Citr

ic a

cid

Oxa

lic a

cid

min.8 12 16 20 24 min.0 10G

luco

se

N-A

cety

lglu

cosa

min

eN

-Ace

tylg

alac

tosa

min

e20

ConditionsColumn EluentFlow rateColumn temp.Detection

：MCI GEL™ CK08EH, 8mm I.D.×300mm：1% H3PO4（Fig.2-13,2-14）：0.6：45℃（Fig. 2-13）, ambient（Fig. 2-14）：210nm（Fig. 2-13）, RI（Fig. 2-14）

Fig. 2-15 Alcohols

：MCI GEL™ CK08EH, 7.8mm I.D.×300mm：60 ℃：2.5 bar：RI：10.0 μL

ConditionsColumn TempPressDetectionInjection

10 20 30 40 50 10 20 30 40 50

Other company's columnMCI GEL™ CK08EH

glyc

erol

Ethy

lene

Gly

col

MeO

H EtO

Hi-P

rOH

n-Pr

OH

sec-

BuO

H

n-Bu

OH

MeO

H EtO

Hi-P

rOH

n-Pr

OH

sec-

BuO

H

n-Bu

OH

glyc

erol

Ethy

lene

Gly

col

2

3

4

5

6

8

9

10

1

3

4

5

6

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9

10

1

2

4

5

6

8

9

10

1

2

3

5

6

8

9

10

1

2

3

4

6

8

9

10

1

2

3

4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



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Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

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ns and materials


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Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



MCI GEL™ colum


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atography colum

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guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

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columns and m


ns and m

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n selectionguide





MCI GEL™ colum


ns and m

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atography colum

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guide


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MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

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guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

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9

1

3

4

5

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7

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9

10 10

1

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4

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1

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3

5

6

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8

9

1

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6

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9

1

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3

4

5

7

8

9

1

2

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4

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9

1

2

3

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5

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9 9

1

2

3

4

5

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1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

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8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

11 12

CK02A 20×250 CK04S 10×200 CK04SS 10×200

Cation exchange columnsapplications; oligosaccharides

Calibration curves of malto-oligosaccharides

CK04S, CK04SSCK02A, CK02AS

Cation exchange columnsapplications; oligosaccharides

Fig. 2-20

�T�h�e� �s�e�p�a�r�a�t�i�o�n� �m�e�c�h�a�n�i�s�m� �i�s� �b�a�s�e�d� �o�n� �g�e�l� �f�i�l�t�r�a�t�i�o�n� �c�h�r�o�m�a�t�o�g�r�a�p�h�y� �a�n�d� �e�l�u�t�i�o�n� �i�s� �a�c�h�i�e�v�e�d� �v�i�a� �s�i�m�p�l�e� �d�i�s�t�i�l�l�e�d� �w�a�t�e�r�.� �A� �l�a�r�g�e�r� �m�o�l�e�c�u�l�e� �e�l�u�t�e�s� �a�h�e�a�d�.

●Separation ability of each column

Fig. 2-21

MCI GEL™ column Counter ion Separation ability（degree of polymerization）

MCI GEL™ CK04S Na+ 8～9

MCI GEL™ CK04SS Ag+ 12～13

MCI GEL™ CK02A Na+ 15～16

MCI GEL™ CK02AS Ag+ 19～20

MCI GEL™ CK04SS�…MCI GEL™ CK04S �…

1510102

103

104

5

MW

MCI GEL™ CK02AS�…MCI GEL™ CK02A �…

30 40 50 60 7020102

103

104

10

MW

2

Elution volumeElution volume

●Peak retention time for Sugars and Sugar alcohols on various columns〔min〕

Column tempColumn sizeElueuntFlow rateSampleInjection vol.

： CK08EC…75℃, CK08E…45℃, CK08ES…75℃： 8mm I.D.×300mm

： H2O： 0.6： 1% aq. solution： 20µl ＊ ; These sugars, containing Fructose component,

may partially be decomposed by CK08ES and CK08EH.

CK08ECCa2＋

CK08ENa＋

CK08ESAg＋

Stachyose

Melezitose

Raffinose

Gentiobiose

Cellobiose

Trehalose

Isomaltose

Sucrose

Maltose

Melibiose

Lactose

Maltulose

Lactulose

Glucose

Xylose

Galactose

Mannose

Rhamonse

Fructose

Fucose

Inositol

Arabinose

Digitoxose

Adonitol

Erythritol

Mannitol

Salicin

Dulcitol

Xylitol

Sorbitol

Ribose

9

10

11

12

13

14

15

16

17

18

20

22

23

24

25

minStachyose

Melezitose

Raffinose

Gentiobiose

Cellobiose

Trehalose

Sucrose

Isomaltose

Melibiose

Maltose

Maltulose

Lactose

Lactulose

Glucose

Mannitol

Rhamonse

Adonitol

Sorbitol

Digitoxose

Mannose

Xylose

Galactose

Fructose

Inositol

Xylitol

Fucose

Dulcitol

Arabinose

Erythritol

Ribose

Salicin

8

9

10

11

12

13

17

15

27

14

min＊Melezitose

＊Stachyose

＊Raffinose

＊Sucrose

Trehalose

Cellobiose

Gentiobiose

Maltose

Isomaltose

Maltulose

Lactose

Melibiose

Lactulose

Adonitol

Digitoxose

Rhamnose

Glucose

Xylose

Xylitol

Erythritol

Mannitol

Fructose

Dulcitol

Galactose

Sorbitol

Mannose

Arabinose

Fucose

Ribose

Inositol

Salicin

12

13

14

15

16

17

18

19

20

20

21

21

23

52

min

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

10

1

2

4

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10

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3

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10

1

2

3

4

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8

9

10

1

2

3

4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

aterialsIon chrom

atography colum

ns and materials


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Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



MCI GEL™ colum


ns and m

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atography colum

ns and materials


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Column selection

guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

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Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


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guide


ns



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


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Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


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Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


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guide




Compounds index

MCI GEL™ colum


ns and m

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atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


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Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

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9

10 10

1

2

4

5

6

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9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

13 14

Comparison data of authentic malto-oligosaccharides samples

Application data of CK04S

Fig. 2-29 Honey

：MCI GEL™ CK04S　10mm I.D.×200mm：H2O ：0.4 （Fig. 2-29, 2-30）0.3 （Fig. 2-31）：85℃（Fig. 2-29, 2-30）45℃（Fig. 2-31）：RI

Fig. 2-30 Jam Fig. 2-31 Fructo-oligosaccharides

Fig. 2-26 MCI GEL™ CK04S10mm I.D.×200mm

Fig. 2-28 MCI GEL™ CK02AS20mm I.D.×250mm

Fig. 2-27 MCI GEL™ CK04SS10mm I.D.×200mm

min.0 10D

p 5 Dp

4D

p 3

Dp

2G

luco

se Glu

cose

Dp

2

Fruc

tose

20 30 min.0 10

Dp

4D

p 3

Fruc

tose

20 30 min.0 10 20

Dp

6 Sucr

ose

Glu

cose

Fruc

tose

Dp

5D

p 4

Dp

3

4030

ConditionsColumn


min.0 10 20 30

Dp

2

Dp

1

Dp

3

Dp

2

Dp

2

Dp

1

Dp

1Dp

3

Dp

3

Dp

7

Dp 6

Dp

5D

p 4

Dp

4

Dp

4

Dp

5

Dp

5

0 min.10 20 30 0 20 40 min.60

Dp

7

Dp

7

Dp 6

Dp

6

Comparison data of malto-oligosaccharides

Fig. 2-22 MCI GEL™ CK04S10mm I.D.×200mm

Fig. 2-23 MCI GEL™ CK04SS10mm I.D.×200mm

Fig. 2-24 MCI GEL™ CK02A20mm I.D.×250mm

Fig. 2-25 MCI GEL™ CK02AS20mm I.D.×250mm

：H2O ：0.4 （Fig. 2-22, 2-23, 2-26, 2-27）　1.0 （Fig. 2-24, 2-25, 2-28）：85℃：RI

ConditionsEluentFlow rate

Column temp.Detection

100 min.20 30 40 50 60 20100 min.30 40 50 60

1

2

Dp 12Dp 13Dp 14Dp 15Dp 16Dp 17Dp 18Dp 19Dp 20

70

1

Dp 16

2Dp 11Dp 12Dp 13Dp 14Dp 15

Mal

tose

Mal

tose

Glu

cose

Glu

cose

Dp

3

Dp

3

Dp

4

Dp

4

Dp

5Dp

5

Dp

6Dp

6

Dp

7

Dp

9D

p 10

Dp

11

Dp

8

Dp

9D

p 10 D

p 7

Dp

8

40 min.8 12 16 20 24 12

2

1

840 min.16 20 24 28 32

2

1

Mal

tose

Glu

cose

Mal

tose

Glu

cose

Dp

3

Dp

3

Dp

4

Dp

4

Dp

5

Dp

5

Dp

6

Dp

6

Dp 9Dp 8Dp 7

Dp 13Dp 12Dp 11Dp 10

Dp

9D

p 8 D

p 7

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

10

1

2

4

5

6

8

9

10

1

2

3

5

6

8

9

10

1

2

3

4

6

8

9

10

1

2

3

4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

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atography colum

ns and materials


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Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







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Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



MCI GEL™ colum


ns and m

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atography colum

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Column selection

guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

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atography colum

ns and materials


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Column selection

guide





MCI GEL™ colum


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Ion chromatography

columns and m


ns and m

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n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


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Column selection

guide


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MCI GEL™ colum


ns and m

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atography colum

ns and materials


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Column selection

guide





MCI GEL™ colum


ns and m

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atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

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atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

15 16

CK10U

CK10U 6×120

High cross linkage cation exchange columnapplications; amino acids, amines, etc

Separation of amino acids

2

High cross linkage cation exchange columnapplications; amino acids, amines, etc

Fig. 2-32 Protein hydrolyzates amino acids

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min.

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3

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ConditionsColumn

Eluent

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：MCI GEL™ CK10U　6mm I.D. × 120mm：A 0.2N Na-citrate buffer pH3.15　B 0.2N Na-citrate buffer pH3.20　C 0.2N Na-citrate buffer pH4.20　D 0.8N Na-citrate buffer pH9.70　4-step-gradient：0.5：55℃：ninhydrin post-column reaction, VIS detector

Separation of amino acids

Fig. 2-33 Valine, β-Alanine Fig. 2-34 γ-Aminobutyric acid

γ-Aminobutyric acid↓

4 8 12 16

min.

2

1

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：MCI GEL™ CK10U　6mm I.D.×120mm：0.3M Na-phosphate pH5.0：0.5：40℃：210nm ：1. Valine　2. β-Alanine

ConditionsColumn

EluentFlow rateColumn temp.DetectionSample

Fig. 2-35 cyclic amino acids

Fig. 2-36 alkyl amino acid

Fig. 2-37 basic amino acid and aromatic amino acids

：MCI GEL™ CK10U　6mm I.D.×120mm：0.2N Na-Citrate buffer pH5.2：0.5：55℃：570nm

ConditionsColumn


：MCI GEL™ CK10U　6mm I.D.×120mm：0.3M NaSO4 (pH5.7)：0.5：60 degree：210nm

ConditionsColumn

EluentFlowTemp.UV

0 2.5 5 7.5 10

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17 18

Anion exchange columnapplications; sugars, carboxylic acids, nucleotidesCA08F Anion exchange columnapplications; sugars, carboxylic acids, nucleotides

2

Application data of CA08F

Fig. 2-38 Sugars


200 min.40 60 80 100

20100 min.30

Lact

ic a

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Form

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：MCI GEL™ CA08F　4.6mm I.D.×250mm：A 0.15M Borate buffer pH7.5　B 0.5M Borate buffer pH9.5　C 0.6M Borate buffer pH9.5　D 0.7M Borate buffer pH8.5　4-step-gradient：0.5：65℃

：2.5% Boric acid, 　5% Monoethanolamine pH7.9　　：1.0　150℃：Fluorescence Ex 360nm, Em 440nm

ConditionsColumn

Eluent

Flow rateColumn temp.Post column reactionReagent

Flow rateTemp. Detection

：MCI GEL™ CA08F　4.6mm I.D.×250mm：0.6M Na2SO4 pH3.0：0.5：60℃：210nm

ConditionsColumn


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Application data of CA08F

0 10 20 30 40 50 60

Asco

rbic

aci

d

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tic a

cid

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cid

Form

ic a

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Fig. 2-40 Carboxylic acids Fig. 2-41 Organic acid


：MCI GEL™ CA08F　4.6mm I.D × 250mm：0.1M NaH2PO4 pH3.3：0.4：55℃：210nm

Glu

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min.0 10 20

min.20 40

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cid

ConditionsColumn


：MCI GEL™ CA08F　4.6mm I.D × 250mm：0.6M Na2SO4 pH2.0：0.5：60℃：210nm

ConditionsColumn


：MCI GEL™ CA08F　lot 5F1502：0.6M Na2SO4 8 (pH4)：0.5：60℃：7.3 Mpa：210nm

ConditionsColumn

EluentFlow rateTempPressUV 2

3

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8

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5

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19 20

High porous type anion exchange columnCDR10 High porous type anion exchange column

2

Application data of CDR10Fig. 2-43 Nucleic acids and related substances

：MCI GEL™ CDR10　4.6mm I.D.×250mm：A H2O　B 6M Acetate buffer pH4.4　A→B 30min linear gradient：0.5：60℃：254nm

Fig. 2-44 Mono-nucleotides：MCI GEL™ CDR10　4.6mm I.D.×250mm：1M Acetate buffer pH3.3：1.2：60℃：254nm

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100 min.20 30 40 50

0 min.10 20 30 40

Cyt

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5'-C

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5'-C

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ConditionsColumn

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ConditionsColumn


Application data of CDR10

Fig. 2-45 Sugars

：MCI GEL™ CDR10　4.6mm I.D.×250mm：A 0.15M Borate buffer pH7.5　B 0.6M Borate buffer pH9.5　A→B60min linear gradient：0.5：65℃

：2.5% Boric acid, 5% Monoethanolamine pH7.9：0.5：150℃：Fluorescence Ex 360nm, Em 440nm

Fig. 2-46 Human urine

：MCI GEL™ CDR10　4.6mm I.D.×250mm：A 0.006M Acetate buffer pH4.4　B 6M Acetate buffer pH4.4　A→B 60min. linear gradient：1.0：60℃：254nm

200 min.40 60 80

0 min.20 40 60D

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ConditionsColumn

Eluent

Flow rateColumn temp.Post column reactionReagentFlow rateTemp. Detection

ConditionsColumn

Eluent


2

3

4

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固相吸着剤

21 22

SCA04 4.6×150 PEEK

Cation chromatography column MCI GEL™ SCK01

Cation chromatography Column MCI GEL™ CHK45/C05

Anion chromatography column MCI GEL™ SCA04

Ion chromatography columns and materials

○Cation chromatography column MCI GEL™ SCK01○Cation chromatography column MCI GEL™ CHK45/C05○Anion chromatography column MCI GEL™ SCA04

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3 Ion chromatography columns and materials

Application data of SCK01

Column list

Fig. 3-1 Monovalent cations

：MCI GEL™ SCK01 6mm I.D.×50mm：5mM HNO3

：1.0：40℃：Conductivity（Fig. 3-1, 3-2, 3-3, 3-4, 3-5）254nm（Fig. 3-6）

Fig. 3-2 Amines Fig. 3-3 Monovalent cations in rain

Fig. 3-4 Monovalent cations in tap water Fig. 3-5 Sports drink Fig. 3-6 Nucloside

min.4 8 min.8

Na

Na

K

Na

K

K

NH4

4 12 min.84 12

min.4 8 min.84 min.84

LiNa

NH4

RbCs

K

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ytid

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min

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e

ConditionsColumn EluentFlow rateColumn temp.Detection

Cation analysis

Pre-columnfor anion analysis MCI GEL™ SCA-PC 8mm I.D×10mm

Pre-columnfor cation analysis MCI GEL™ SCK-PC

MCI GEL™ CHK45/C05

6mm I.D×50mm

MCI GEL™ SCK01 6mm I.D×50mm Stainless steelcolumn

Stainless steelcolumn



PEEK column


Anion analysis MCI GEL™ SCA04 4.6mm I.D×150mm

4.6mm I.D×150mm

Cation analysis

Cation analysis

MCI GEL™ SCK01 4.6mm I.D×150mm

*USP L31 column

2

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Column selection

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MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

23 24

Application data of SCK01

Application data of CHK45/C05

Fig. 3-7 Alkaline earth metals

Fig. 3-10 Mono, Divalent cations

Fig. 3-8 Transition metals Fig. 3-9 Divalent cations

min.84 84

Zn Mn CaCo

Cd Sr

min.16 min.4

Ca

Mg

12

Ba

Sr

CaMg

：MCI GEL™ CHK45/C05（SUS)　4.6mm I.D.×150mm：4mM　H2SO4

：1.2：40℃：Conductivity：100μL Li（0.5ppm)，Na（1ppm），NH4（1ppm)，K（4ppm），Mg（4ppm），Ca（4ppm）

ConditionsColumn

EluentFlow rateTemp.DetectionSample　inj

2

Li+

K+

Na-

NH4-

Ca2+

Mg2+

AMAL

7

4 6 8 10 12

(Data provided by Professor Yokoyama of Yokohama National University)

Application data of SCA04

Fig. 3-11 Standard anions eluent ; VA/MDEA

Fig. 3-12 Standard anions eluent ; Potassium hydrogenphthalate

min.4 363228242016128

1

3

4

52

6

7

（System peak）

min.4 208 12 16

1

2

3

4

5

6 ：MCI GEL™ SCA04　4.6mm I.D.×150mm：3mM KHP：1.2：40℃：Conductivity：1. F-　2. C　3. NO2-　4. Br-　5. NO3-　6. SO42-

ConditionsColumn


：MCI GEL™ SCA04　4.6mm I.D.×150mm：3mM VA 2.8mM MDEA pH6.2：1.2：40℃：Conductivity：1. F-　2. H2PO4-　3. C　4. NO2-　5. Br-　6. NO3-　7. SO42-

ConditionsColumn


Fig. 3-13 Rain

A; Beginning of rain fall B; After 4 hours C; After 38 hours

71ppm 59ppm

22ppm

16 min.4 8 12 16 min.4 8 12 16 min.4 8 12

8ppmNO3-

19ppmSO42-

5ppm15ppm

2ppm6ppm

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

10

1

2

4

5

6

8

9

10

1

2

3

5

6

8

9

10

1

2

3

4

6

8

9

10

1

2

3

4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


ns



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

25 26

Application data of SCA04

Fig. 3-14 River water

：MCI GEL™ SCA04　4.6mm I.D.×150mm：3mM VA 2.8mM MDEA pH6.2：1.2：40℃：Conductivity

Conditions（Fig. 3-14, 3-15）Column


55ppmHCO3-

min.4 208 12 16

16ppm

8ppmNO3-

23ppmSO42-

Fig. 3-15 Sulfur compounds

Fig. 3-16 Instant coffee

4 20 min.8 12 16

1

2

3

Chloride

4 40 min.8 12 16 20 24 28 32 36

Nitrate

：MCI GEL™ SCA04　4.6mm I.D.×150mm：3.8mM VA 2.1mM MDEA pH4.5：1.2：40℃：Conductivity

ConditionsColumn


：MCI GEL™ SCA04　4.6mm I.D.×150mm：4mM KHP pH4.1：1.2：40℃：Conductivity：1. SO42- 　2. S2O32-　3. SCN-

ConditionsColumn


L25

L38

L37, L38

Bioseparation columns and materials


○Ion-exchange chromatography columns　XtalSpeed™ series

○Size-exclusion chromatography columns　MCI GEL™ CQP series

�M�C�I� �G�E�L�T�M �b�i�o�s�e�p�a�r�a�t�i�o�n� �c�o�l�u�m�n�s� �a�r�e� �b�a�s�e�d� �o�n� �a� �h�y�d�r�o�p�h�i�l�i�c�,� �w�i�d�e�-�p�o�r�e�,� �a�n�d� �r�i�g�i�d� �p�o�l�y�m�e�r� �d�e�s�i�g�n�e�d� �f�o�r� �a�n�a�l�y�t�i�c�a�l� �c�h�r�o�m�a�t�o�g�r�a�p�h�y� �o�f� �p�r�o�t�e�i�n�s�,� �p�e�p�t�i�d�e�s�,� �e�n�z�y�m�e�s�,� �a�n�d� �o�t�h�e�r� �b�i�o�m�o�l�e�c�u�l�e�s�.

�M�C�I� �G�E�L�T�M �C�Q�P� �s�e�r�i�e�s� �a�r�e� �u�s�e�d� �f�o�r� �s�i�z�e�-�e�x�c�l�u�s�i�o�n� �c�h�r�o�m�a�t�o�g�r�a�p�h�y�.

�X�t�a�l�S�p�e�e�d�T�M �s�e�r�i�e�s� �a�r�e� �i�o�n�-�e�x�c�h�a�n�g�e� �c�o�l�u�m�n�s� �u�s�e�d� �f�o�r� �p�r�o�t�e�i�n� �p�u�r�i�f�i�c�a�t�i�o�n�.� �H�i�g�h�-�q�u�a�l�i�t�y� �t�a�r�g�e�t� �p�r�o�t�e�i�n�s� �a�r�e� �o�b�t�a�i�n�e�d� �w�i�t�h� �t�h�i�s� �c�o�l�u�m�n� �a�t� �a� �h�i�g�h� �r�e�c�o�v�e�r�y� �r�a�t�e�.� �X�t�a�l�S�p�e�e�d�T�M �s�e�r�i�e�s� �a�r�e� �u�s�e�d� �f�o�r� �b�o�t�h� �a�n�a�l�y�t�i�c�a�l� �a�n�d� �p�r�e�p�a�r�a�t�i�v�e� �p�u�r�p�o�s�e� �i�n� �p�r�o�t�e�i�n� �c�r�y�s�t�a�l�l�o�g�r�a�p�h�y� �a�n�d� �N�M�R� �r�e�s�e�a�r�c�h�.� �X�t�a�l�S�p�e�e�d�T�M �s�e�r�i�e�s� �a�r�e� �a�l�s�o� �u�s�e�d� �f�o�r� �a�n�t�i�b�o�d�y� �v�a�r�i�a�n�t� �a�n�a�l�y�s�i�s� �a�n�d� �p�r�o�t�e�i�n� �i�s�o�f�o�r�m� �a�n�a�l�y�s�i�s�.

Column name Type

4 Bioseparation columns and materials

USP Separation mode

MCI GEL™ CQP06

MCI GEL™ CQP10

MCI GEL™ CQP30

XtalSpeed™ SP01

XtalSpeed™ DA

Cation exchange

Anion exchange

Size exclusion

Size exclusion

Size exclusion

Sulfopropyl(SP)

Diethyl amino ethyl(DEAE)

Exclusion limit MW

Exclusion limit MW

Exclusion limit MW

～103

～104

～106



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


ns



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

10

1

2

4

5

6

8

9

10

1

2

3

5

6

8

9

10

1

2

3

4

6

8

9

10

1

2

3

4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

27 28

DA01

Φ4.6mm×50mm

Φ4.6mm×100mm

Φ7.5mm×100mm

Φ11.5mm×100mm

Name CodeColumn size Housing Functional Group

0-151-01

0-151-04

0-151-02

0-151-03

PEEK Diethylaminoethyl(DEAE)

SP01

Φ4.6mm×50mm

Φ4.6mm×100mm

Φ7.5mm×100mm

Φ11.5mm×100mm

0-152-01

0-152-04

0-152-02

0-152-03

PEEK Sulfopropyl (SP)

Ion exchange chromatography columns

Ion exchange chromatography columns

Column list

XtalSpeedTM series Ion exchange chromatography columns

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4Application data of XtalSpeed™ series

Fig. 4-1 Analysis of Rituximab

Fig. 4-2 Analysis of Hemoglobin A1C

Fig. 4-3 Comparison of loadability

-1.00E+04 4 8 12 16 20min

0

0.00E+00

1.00E+04

2.00E+04

3.00E+04

4.00E+04

VIS

415n

m(u

V) 5.00E+04

6.00E+04

7.00E+04

8.00E+04

9.00E+04

-1.00E+04 4 8 12 16 20min

0

0.00E+00

1.00E+04

2.00E+04

3.00E+04

4.00E+04

VIS

415n

m(u

V)

5.00E+04

6.00E+04

7.00E+04

8.00E+04

9.00E+04Hb A0

Hb A1c

Hb A0

Hb A1c

min min1050 25 302015 1050 25 302015

：XtalSpeed™ SP01 100 x 4.6mmI.D Column A (250 x 4mmI.D)

ConditionsColumn

：A, 20mM Na phophate (pH7.0) B, A + 1.0M NaCl：0.529 for XtalSpeed and 1.0 for ProPac：(A), 2.5-20.0%B over 30min + 20.0-100%B over 5min (C), 2.5-5.0%B over 30min + 5.0-100%B over 5min

Eluent

Flow rateGradient

Conditions：

：

：0-40%B（0-400mM NaCl)/40CV：50 micro grams of human kinase

Eluent

Flow rate

GradientSample

XtalSpeed™ SP 01column A

XtalSpeed™ SP 01column A

：XtalSpeed™ SP01 50 x 4.6mmI.D

ConditionsColumn

：A, 20mM Bis-Tris-HCl (pH6.0) B, A + 1M NaCl：0.5：5 - 40%B over 30min：VIS 415nm：35℃

Eluent

Flow rateGradientDetectionTemperature

Able-bodied person Diabetic patient

XtalSpeedTM DA01 (4.6*50mm)

Impu

ritie

s

kina

se

Impu

ritie

s

kina

se

Column Q (4.6*100mm)

XtalSpeedTM DA01 :0.6Competitor’s Column Q:1

Buffer A:50mM HEPES-NaOH(pH7)Buffer B:50mM HEPES-NaOH(pH7),1M NaCl

32 34 36 38 4032 3428 30 36 38 40 42

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充填カラム

MCI

GEL

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7

固相吸着剤

29 30

Aqueous size exclusion columns

Size exclusion chromatography columns

Column list

CQP series Aqueous size exclusion columns

MCI GEL™ column

MCI GEL™ CQP06

MCI GEL™ CQP10

Column dimensions Particle size[μm]

Packing materials

Pore size[nm]

Theoreticalplates number[TP／column]

Exclusion limit[PEG]

7.5mm I.D. ×600mm

USP

L25

L38

L37, L38

7.5mm I.D. ×600mm

10

10

12

20

10000

6000

～1×103

～1×104

MCI GEL™ CQP30 7.5mm I.D. ×600mm 10 60 6000 ～1×106

●CQP series

MCI GEL™ column

MCI GEL™ CQP06G

MCI GEL™ CQP10G

Column dimensions

4.0mm I.D.×50mm

4.0mm I.D.×50mm

MCI GEL™ CQP30G 4.0mm I.D.×50mm

●Guard columns

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4Application data of CQP series

Fig. 4-4 Calibration curve

：MCI GEL™ MCI GEL™ MCI GEL™　7.5mm I.D.×600mm：H2O：1.0：ambient：RI：PEG 100μl inj.

Fig. 4-5 Separation of PEG mixture

：MCI GEL™ CQP30 7.5mm I.D.×600mm：H2O：1.0：25℃：RI：1. PEG　2. 　3.

145,00040,0006,000

Fig. 4-6 Separation of protein mixture Fig. 4-7 Separation of gluconic acid and glucose

：MCI GEL™ CQP06 7.5mm I.D.×600mm：H2O：0.8：ambient：RI：1. 5% Gluconic acid　2. 5% Glucose

：MCI GEL™ CQP30 7.5mm I.D.×600mm：14mM：1.0：ambient：280nm：1. Ferritin（MW440,000）　2. Ovalbumin（MW43,000）　3. Myoglobin（MW17,500）　4. Cytochrome c（MW12,400）

10 15

CQP 10

CQP 30

CQP 06

20 2010

1

2

3

0 min.

20 3010

1

1

2

2

3

4

0 min.0 10 20 30 40 min.

MW

102

103

104

105

106

ConditionsColumn


ConditionsColumn EluentFlow rateColumn temp.DetectionSample



Elution volume

CQP06CQP10CQP30

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

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1

2

4

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2

3

4

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1

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4

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8

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1

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及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

31 32

Analytical and preparative chromatography columns and materials for pharmaceutical applications5 Analytical and preparative chromatography columns and materials for pharmaceutical applications

MCI GEL™ CHP20/C04

Separation mechanism of CHP series

●Description of MCI GELTM columns and materials

C＝ColumnP＝Material

Matrix type Particle size

○Polymeric partition chromatography columns and materials MCI GEL™ CHP series

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�M�C�I� �G�E�L�T�M� �s�p�e�c�i�a�l�i�z�e�s� �i�n� �p�o�l�y�m�e�r�-�b�a�s�e�d� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s�.� �T�h�e� �u�s�e� �o�f� �p�o�l�y�m�e�r�-�b�a�s�e�d� �c�o�l�u�m�n�s� �h�a�s� �b�e�c�o�m�e� �m�o�r�e� �w�i�d�e�s�p�r�e�a�d� �t�h�a�n�k�s� �t�o� �t�h�e� �m�a�n�y� �a�d�v�a�n�t�a�g�e�s� �o�f� �t�h�e� �p�o�l�y�m�e�r� �m�a�t�r�i�x� �l�i�k�e� �e�x�c�e�l�l�e�n�t� �s�e�l�e�c�t�i�v�i�t�y�,� �t�h�e� �a�b�s�e�n�c�e� �o�f� �s�p�e�c�i�f�i�c� �a�d�s�o�r�p�t�i�o�n� �w�h�i�c�h� �i�s� �f�o�u�n�d� �c�o�m�m�o�n�l�y� �w�i�t�h� �s�i�l�i�c�a�-�b�a�s�e�d� �p�a�c�k�i�n�g�,� �o�p�e�r�a�b�i�l�i�t�y� �i�n� �a� �w�i�d�e� �p�H� �r�a�n�g�e� �a�n�d� �g�o�o�d� �c�h�e�m�i�c�a�l� �s�t�a�b�i�l�i�t�y� �d�u�e� �t�o� �t�h�e� �i�n�e�r�t� �n�a�t�u�r�e� �o�f� �p�o�l�y�m�e�r�i�c� �m�a�t�e�r�i�a�l�s�.� �T�h�e� �M�C�I� �G�E�L�T�M� �p�a�r�t�i�t�i�o�n� �c�h�r�o�m�a�t�o�g�r�a�p�h�y� �c�o�l�u�m�n�s� �a�r�e� �b�a�s�e�d� �o�n� �a� �p�o�l�y�s�t�y�r�e�n�e� �a�n�d� �p�o�l�y�m�e�t�h�a�c�r�y�l�a�t�e� �p�o�r�o�u�s� �p�o�l�y�m�e�r�.� �A�s� �R�P� �c�o�l�u�m�n�s�,� �t�h�e�y� �a�r�e� �a�p�p�l�i�e�d� �t�o� �t�h�e� �s�e�p�a�r�a�t�i�o�n� �o�f� �a� �w�i�d�e� �v�a�r�i�e�t�y� �o�f� �o�r�g�a�n�i�c� �c�o�m�p�o�u�n�d�s�,� �b�o�t�h� �i�n� �t�h�e� �i�s�o�c�r�a�t�i�c� �a�n�d� �g�r�a�d�i�e�n�t� �e�l�u�t�i�o�n� �m�o�d�e�.� �T�h�e� �c�o�m�p�o�u�n�d�s� �i�n�c�l�u�d�e� �p�e�p�t�i�d�e�s�,� �i�n�s�u�l�i�n�,� �s�m�a�l�l� �m�o�l�e�c�u�l�e� �A�P�I�s�,� �n�u�t�r�a�c�e�u�t�i�c�a�l� �c�o�m�p�o�u�n�d�s�,� �w�a�t�e�r�-�s�o�l�u�b�l�e� �v�i�t�a�m�i�n�s� �a�n�d� �n�u�c�l�e�o�t�i�d�e�s�.� �A�s� �N�P� �c�o�l�u�m�n�s�,� �t�h�e�y� �a�r�e� �u�s�e�d� �i�n� �t�h�e� �s�e�p�a�r�a�t�i�o�n� �o�f� �v�a�r�i�o�u�s� �c�a�r�o�t�e�n�o�i�d�s�,� �f�a�t�-�s�o�l�u�b�l�e� �v�i�t�a�m�i�n�s�,� �s�t�e�r�o�i�d�s�,� �a�n�d� �f�o�o�d� �a�d�d�i�t�i�v�e�s�.� �T�h�e�s�e� �c�o�l�u�m�n�s� �t�o�l�e�r�a�t�e� �v�a�r�i�o�u�s� �o�r�g�a�n�i�c� �s�o�l�v�e�n�t�s� �l�i�k�e� �h�e�x�a�n�e�,� �h�e�p�t�a�n�e�,� �m�e�t�h�y�l�e�n�e� �c�h�l�o�r�i�d�e�,� �a�n�d� �a�l�c�o�h�o�l�s�.� �A�s� �N�P� �c�o�l�u�m�n�s�,� �t�h�e�y� �a�r�e� �u�s�e�d� �i�n� �t�h�e� �s�e�p�a�r�a�t�i�o�n� �o�f� �v�a�r�i�o�u�s� �c�a�r�o�t�e�n�o�i�d�s�,� �f�a�t�-�s�o�l�u�b�l�e� �v�i�t�a�m�i�n�s�,� �s�t�e�r�o�i�d�s�,� �a�n�d� �f�o�o�d� �a�d�d�i�t�i�v�e�s�.� �V�a�r�i�o�u�s� �o�r�g�a�n�i�c� �s�o�l�v�e�n�t�s� �l�i�k�e� �H�e�x�a�n�e� �H�e�p�t�a�n�e�,� �m�e�t�h�y�l�e�n�e� �c�h�l�o�r�i�d�e� �a�n�d� �a�l�c�o�h�o�l�s� �c�a�n� �b�e� �u�s�e�d�.

�T�h�e� �M�C�I� �G�E�L�T�M� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s� �a�r�e� �b�a�s�e�d� �o�n� �t�h�e� �s�a�m�e� �c�h�e�m�i�s�t�r�i�e�s� �o�f�f�e�r�e�d� �i�n� �t�h�e� �D�i�a�i�o�n�T�M� �a�n�d� �S�e�p�a�b�e�a�d�s�T�M� �s�y�n�t�h�e�t�i�c� �a�d�s�o�r�b�e�n�t� �r�e�s�i�n�s�.� �T�h�e�s�e� �p�o�l�y�m�e�r� �c�h�e�m�i�s�t�r�i�e�s�,� �l�i�k�e� �D�i�a�i�o�n�T�M� �H�P� �s�e�r�i�e�s� �a�n�d� �S�e�p�a�b�e�a�d�s�™� �S�P� �s�e�r�i�e�s�,� �a�r�e� �w�i�d�e�l�y� �u�s�e�d� �a�n�d� �d�o�c�u�m�e�n�t�e�d� �i�n� �t�h�e� �b�i�o�p�h�a�r�m�a�c�e�u�t�i�c�a�l� �i�n�d�u�s�t�r�y� �f�o�r� �f�e�r�m�e�n�t�a�t�i�o�n� �e�x�t�r�a�c�t�i�o�n�,� �t�h�e� �f�o�o�d� �i�n�d�u�s�t�r�y� �a�n�d� �i�n� �i�n�d�u�s�t�r�i�a�l� �c�h�r�o�m�a�t�o�g�r�a�p�h�i�c� �s�e�p�a�r�a�t�i�o�n�s�.� �T�h�e� �M�C�I� �G�E�L�T�M� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s� �a�r�e� �a�v�a�i�l�a�b�l�e� �a�s� �p�a�c�k�e�d� �c�o�l�u�m�n�s� �f�o�r� �a�n�a�l�y�t�i�c�a�l� �a�p�p�l�i�c�a�t�i�o�n�s�,� �a�n�d� �a�s� �b�u�l�k� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s� �f�o�r� �a�n�a�l�y�t�i�c�a�l�,� �p�r�e�p�a�r�a�t�i�v�e� �a�n�d� �p�r�o�d�u�c�t�i�o�n� �c�h�r�o�m�a�t�o�g�r�a�p�h�y� �a�p�p�l�i�c�a�t�i�o�n�s�.

5 4.6×150CHK45/C05

*CHP20/C04, CHP20/C10: USP classification is L21

Br

None

Cation exchange group

None

C18

4

10

4.6×15020×150

4

10

4.6×15020×200

4.6×1504.6×25010×25020×15020×250

4.6×1504.6×25010×15020×15020×250

CHP20/C04

44.6×15020×200CHPOD/C04

CHP20/C10

CHP07/C04

CHP07/C10

4 4.6×150CHK40/C04

4

10

4.6×15020×150

4.6×1504.6×25010×25020×15020×250

CMG20/C04

CMG20/C10

Weak cationexchange group

Column list●CHP column series

5

�M�C�I� �G�E�L�T�M� �C�H�P� �s�e�r�i�e�s� �a�r�e� �s�u�i�t�a�b�l�e� �f�o�r� �R�P� �a�n�d� �N�P� �c�h�r�o�m�a�t�o�g�r�a�p�h�y�.� �T�h�e�r�e� �a�r�e� �f�o�u�r� �k�i�n�d�s� �o�f� �c�o�l�u�m�n�s� �o�f� �v�a�r�i�o�u�s� �h�y�d�r�o�p�h�o�b�i�c�i�t�i�e�s�;� �p�o�r�o�u�s� �p�o�l�y�s�t�y�r�e�n�e�,� �m�o�d�i�f�i�e�d� �p�o�r�o�u�s� �p�o�l�y�s�t�y�r�e�n�e�,� �p�o�l�y�m�e�t�h�a�c�r�y�l�a�t�e�,� �a�n�d� �m�o�d�i�f�i�e�d� �p�o�r�o�u�s� �p�o�l�y�m�e�t�h�a�c�r�y�l�a�t�e�.� �T�h�i�s� �r�a�n�g�e� �o�f� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s� �o�f�f�e�r�s� �t�r�e�m�e�n�d�o�u�s� �s�c�o�p�e� �f�o�r� �a� �p�r�o�p�e�r� �s�e�l�e�c�t�i�o�n� �o�f� �c�o�l�u�m�n�s� �b�a�s�e�d� �o�n� �t�h�e� �p�r�o�p�e�r�t�i�e�s� �o�f� �t�h�e� �t�a�r�g�e�t� �c�o�m�p�o�u�n�d�s�.

Full range

Column size[mm I.D.×mm]

Particle size[μm] pH range

�P�o�l�y�s�t�y�r�e�n�e� �p�a�c�k�i�n�g�:� �M�C�I� �G�E�L�T�M� � �C�H�P�2�0�/�C�0�4�,� �C�H�P�2�0�/�C�1�0�M�o�d�i�f�i�e�d� �p�o�l�y�s�t�y�r�e�n�e� �p�a�c�k�i�n�g�:� �M�C�I� �G�E�L�T�M� � �C�H�P�0�7�/�C�0�4�,� �C�H�P�0�7�/�C�1�0�,� �C�H�K�4�0�/�C�0�4�P�o�l�y�m�e�t�h�a�c�r�y�l�a�t�e� �p�a�c�k�i�n�g�:� �M�C�I� �G�E�L�T�M� � �C�M�G�2�0�/�C�1�0�M�o�d�i�f�i�e�d� �p�o�l�y�m�e�t�h�a�c�r�y�l�a�t�e� �p�a�c�k�i�n�g�:� �M�C�I� �G�E�L�T�M� � �C�H�P�O�D�/�C�0�4�,� �C�H�K�4�5�/�C�0�5

MCI GEL™ CHP07/C04, C10 > CHP20/C04, C10 > CHPOD/C04 ≥ ODS columns ≥ CMG20/C04, C10�P�o�l�y�m�e�r� �c�o�l�u�m�n�s� �f�o�r� �H�P�L�C�,� �w�i�t�h� �t�h�e�i�r� �s�u�p�e�r�i�o�r� �c�h�e�m�i�c�a�l� �r�e�s�i�s�t�a�n�c�e�,� �c�a�n� �b�e� �u�s�e�d� �w�i�t�h� �v�a�r�i�o�u�s� �m�o�b�i�l�e� �p�h�a�s�e�s� �o�f� �b�r�o�a�d� �p�H� �r�a�n�g�e�,� �a�c�i�d�i�c� �t�h�r�o�u�g�h� �a�l�k�a�l�i�n�e�.� �T�h�e�y� �h�a�v�e� �t�h�e� �f�o�l�l�o�w�i�n�g� �a�d�v�a�n�t�a�g�e�s� �d�u�e� �t�o� �t�h�e�i�r� �h�i�g�h� �h�y�d�r�o�p�h�o�b�i�c�i�t�i�e�s�:�1）�I�n� �r�e�v�e�r�s�e� �p�h�a�s�e� �c�h�r�o�m�a�t�o�g�r�a�p�h�i�c� �m�e�t�h�o�d�s� �t�o� �s�e�p�a�r�a�t�e� �a�c�i�d�i�c� �o�r� �a�l�k�a�l�i�n�e� �c�o�m�p�o�u�n�d�s�,� �e�l�u�e�n�t�s� �t�h�a�t� �c�a�n� �s�u�p�p�r�e�s�s� �t�h�e�

ionic properties of such compounds are generally used. Polymer columns can be applied in these cases where ODS �c�o�l�u�m�n�s� �w�o�u�l�d� �b�e� �u�n�s�u�i�t�a�b�l�e�.

�2）Some extremely hydrophilic compounds, e.g., oligosaccharides, can be separated using strongly hydrophobic �C�H�P�0�7�/�C�0�4� �o�r� �C�H�P�0�7�/�C�1�0� �c�o�l�u�m�n�s�.

�3）� �P�o�l�y�m�e�r� �c�o�l�u�m�n�s� �c�a�n� �b�e� �w�a�s�h�e�d� �w�i�t�h� �a�c�i�d�i�c� �a�n�d�/�o�r� �b�a�s�i�c� �s�o�l�u�t�i�o�n�s� �i�n� �c�a�s�e� �o�f� �c�o�n�t�a�m�i�n�a�t�i�o�n�.�P�o�l�y�m�e�t�h�a�c�r�y�l�a�t�e� �c�o�l�u�m�n�s�,� �C�M�G�2�0�/�C�0�4� �a�n�d� �C�M�G�2�0�/�C�1�0�,� �c�a�n� �b�e� �a�p�p�l�i�e�d� �b�o�t�h� �f�o�r� �r�e�v�e�r�s�e� �p�h�a�s�e� �a�n�d� �n�o�r�m�a�l� �p�h�a�s�e� �c�h�r�o�m�a�t�o�g�r�a�p�h�y�.Modified polystyrene packing, CHK40/C04, is a mixed-mode type material; both hydrophobic and hydrophilic �i�n�t�e�r�a�c�t�i�o�n�s� �o�c�c�u�r� �b�e�t�w�e�e�n� �t�h�e� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l� �s�u�r�f�a�c�e� �a�n�d� �t�h�e� �a�n�a�l�y�t�e�s�.� �T�h�i�s� �m�a�t�e�r�i�a�l� �i�s� �u�s�e�f�u�l� �f�o�r� �c�o�m�p�o�u�n�d�s� �t�h�a�t� are difficult to separate using existing ODS or other polymer-based columns. This column is also used in the normal �p�h�a�s�e� �m�o�d�e� �a�n�d� �s�h�o�w�s� �a� �u�n�i�q�u�e� �s�e�p�a�r�a�t�i�o�n� �p�r�o�f�i�l�e�.� All polymeric columns exhibit superior stability and yield in comparison to ODS columns, which may have free silanol groups even when end-capping agents have been used.

�T�h�e� �h�y�d�r�o�p�h�o�b�i�c�i�t�i�e�s� �o�f� �t�h�e� �c�o�l�u�m�n�s� �a�r�e� �i�n� �t�h�e� �f�o�l�l�o�w�i�n�g� �o�r�d�e�r�s�:

Product nameMatrix Type Functinal group USP

2～12

L21

Analytical and preparative chromatography columns and materials for pharmaceutical applicationsCHP column series

Styrene Divinylbenzene

Methacrylates


2

3

4

5

6

8

9

10

1

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9

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8 8

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10 10

1

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8

1

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5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

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aterialsColum

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MCI GEL™ colum


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guide

MCI GEL™ colum


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and materials

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columns and m

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guide

MCI GEL™ colum


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SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

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columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






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Ion chromatography

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aterialsColum

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MCI GEL™ colum

n list

MCI GEL™ colum

n list


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and materials


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ns and materials


and materials

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guide

MCI GEL™ colum

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and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



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Compounds index



and materials

Ion chromatography

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ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

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atography colum

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guide

MCI GEL™ colum

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SPE sorbent series







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aterialsColum

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MCI GEL™ colum


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Compounds index

Compounds index

MCI GEL™ colum


ns and m

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atography colum

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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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atography colum

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MCI GEL™ colum


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MCI GEL™ colum








MCI GEL™ colum


ns and m

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atography colum

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guide


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Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

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7

8

9

1

3

4

5

6

7

8

9

10 10

1

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7

8

9

1

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3

5

6

7

8

9

1

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4

6

7

8

9

1

2

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5

7

8

9

1

2

3

4

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9

1

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9 9

1

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8

1

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9

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8

1

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7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

33 34

Durability of polymeric column

Fig. 5-1 Column durability at pH12 comparison between CHP20/C04 and an ODS column

�T�h�e� �p�o�l�y�m�e�r�i�c� �R�P� �c�o�l�u�m�n�s� �a�r�e� �c�h�e�m�i�c�a�l�l�y� �s�t�a�b�l�e�.� �S�p�e�c�i�f�i�c�a�l�l�y�,� �t�h�e� �c�o�l�u�m�n�s� �h�a�v�e� �r�e�s�i�s�t�a�n�c�e� �t�o� �a�n� �a�l�k�a�l�i�n�e� �e�l�u�e�n�t�.� �T�h�e� �f�o�l�l�o�w�i�n�g� �g�r�a�p�h�s� �d�e�m�o�n�s�t�r�a�t�e� �s�t�a�b�i�l�i�t�y� �o�f� �t�h�e� �p�o�l�y�m�e�r�i�c� �c�o�l�u�m�n�s�.� �A�f�t�e�r� �f�e�e�d�i�n�g� �a� �s�o�l�u�t�i�o�n� �o�f� �p�H� �1�2� �i�n�t�o� �t�h�e� �M�C�I� �G�E�L�™� �C�H�P�2�0�/�C�0�4�,� �t�h�e�r�e� �i�s� �n�o� �c�h�a�n�g�e� �o�f� �c�o�l�u�m�n� �p�e�r�f�o�r�m�a�n�c�e�.

100 150 200500

1,2

0.4

0.6

0.2

0.8

1

0

degr

adat

ion

ratio

fiowing time hr.

CHP20/C04

ODS column

100 150 200500

1,2

0.4

0.6

0.2

0.8

1

0

degr

adat

ion

ratio

fiowing time hr.

CHP20/C04

ODS column

：MCI GEL™ CHP20/C04 4.6mmI.D × 150mm：20mM Na2HPO4 pH12/CH3CN/=60/40：0.4：25℃：254nm：1000ppm Dimethyl phthalate 5µL


COOH

NH2 H2N-CH2(CH2)2-CH3

Polystyrenic adsorbent Silica gel C4, C18 Polymethacrylic adsorbent

Polymethacrylic adsorbent Silica gel C4, C18

π-π interaction(double bond effect) Alkyl effect

Hydrogen bond effect Hydrogen bond effect

Hydrogen bond effect

HN

NH2

COOHNH

H2N

(CH2)n-CH3O

SiSi

H2N-CH2 HN NH

HN

OHO O

O OCOH

OSi

Si

H2NCOOH

NH2NH

HN

C

O O

O OC

C

Retentiveness in reverse phase mode

Hydrophobic interaction Interaction mechanism

Weak interactionStronge interaction

Hydrophobic interaction

Interaction mechanism

1

2

3

4

5

0 5 10 15 20 25 30 35 40 min.

1

2

3

0 5 10 15 20 25 30 35 40 min.

MeOOC COOMe

Phthalic acid dimethyl ester

EtOOC COOEt

Phthalic acid diethyl ester

PrOOC COOPr

Phthalic acid dipropyl ester

Application data of CHP series

：MCI GEL™ CHP20/C04　4.6mm I.D.×150mm：50mM Na-phosphate pH2.0,　1.5% Hexanesulfonic acid / 　CH3CN＝80/20：0.25：ambient：280nm：1. Epinephrine　2. Dopamine　3. 5-Hydroxy tryptophan　4. Serotonin　5. Tryptophan

ConditionsColumn

Eluent

Flow rateColumn temp.DetectionSample

：MCI GEL™ CHP20/C04　4.6mm I.D.×150mm：H2O/CH3CN＝50/50：0.75：60℃：254nm：1. Dimethyl phthalate　2. Diethyl phthalate　3. Dipropyl phthalate

ConditionsColumn


ConditionsColumn


：MCI GEL™ CHP20/C04　4.6mm I.D.×150mm：H2O/CH3CN=10/90：0.4：25℃：275nm ：1.Theophylline　2.Theobromine　3.Caffeine

ConditionsColumn

Eluent


：MCI GEL™ CHP20/C04　4.6mm I.D.×150mm：0.1M NaH2PO4 pH2.0 CH3CN=88/12：0.3：25℃：275nm ：1.Cinchonine　2.Quinine

Fig. 5-2 Separation of catecholamines Fig. 5-3 Separation of phthalic acid esters

HO

HOOH H

N

Epinephrine

HO

HO NH2

Dopamine

HO

NH

NH2

COOH

5-hydroxy tryptophan

HO

NH

NH2

Serotonin

12

3

0 5 10 15 20 25 min.

1

2

0 5 10 15 20 25 min.

Fig. 5-4 Purine alkaloids Fig. 5-5 Cinchona alkaloids

HN

N N

N

O

O

Theophylline

N

N N

HN

O

O

Theobromine

N

N N

N

O

O

Caffeine

N

HOHH

H

H

N

Cinchonine

N

HOHH

H

H

N

O

Quinine

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

10

1

2

4

5

6

8

9

10

1

2

3

5

6

8

9

10

1

2

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4

6

8

9

10

1

2

3

4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

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MCI GEL™ colum


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SPE sorbent series

SPE sorbent series

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SPE sorbent series





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MCI GEL™ colum

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Compounds index



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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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guide

MCI GEL™ colum








MCI GEL™ colum


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Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

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2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

35 36


Comparison with an ODS column

Fig. 5-6 Uric acid and related compounds

Fig. 5-7 Bile acidsCHP20/C04

ODS column

1

2

3

1

3

2

13

2

4 5

0 5 10 15 20 min.

0 5 10 15 20 min.

0 5 10 15 20 min.

ConditionsColumn


：MCI GEL™ CHP20/C04　4.6mm I.D.×150mm：10mM TBA/CH3CN=75/25：0.4：25℃：284nm ：1.Hypoxanthine　2.Xanthine　3.Theophylline　4.Uric acid　5.Orotic acid

ConditionsColumn

Eluent


：MCI GEL™ CHP20/C04　4.6mm I.D.×150mm：50mM NaH2PO4 pH2.0 /CH3CN＝40/60：0.3：25℃：210nm：1.Cholic acid　2.Ursodeoxycholic acid　3.Deoxycholic acid

ConditionsColumn

Eluent


：ODS column (5μm)　4.6mm I.D.×150mm：50mM NaH2PO4 pH6.0 /CH3CN＝40/60：0.3：25℃：210nm：1.Cholic acid　2.Ursodeoxycholic acid　3.Deoxycholic acid

N

N NH

HN

O

Hypoxanthine

HN

N N

N

O

O

Theophylline

HN

NH

N

HN

O

O

Xanthine

NH

HN

COOH

O

Orotic acid

O

HN

NH

N

HN

O

O

HO

Uric acid

H

OHH

COOH

HO

Ursodesoxycholic acid

H

OHH

COOH

HO

cholic acid

OH

H

H

COOH

HO

deoxycholic acid

OH


Fig. 5-9 Adrenal cortex hormones

Fig. 5-8 Glycyrrhizae radix

min.

min.

Glycyrrhizic acid

0 30 35 4020 2515105

2

3

1

0 3020 2515105

ConditionsColumn

Eluent


：MCI GEL™ CHP20/C04　4.6mm I.D.×150mm：2.06% acetic acid/CH3CN =63/37：0.5：45℃：254nm：Extract of　glycyrrhizae radix

ConditionsColumn

Eluent


：MCI GEL™ CHP20/C04　4.6mm I.D.×150mm：H2O/CH3CN：60/40：0.5：45℃：280nm：1.Hydrocortisone　2.Corticosterone　3.11-Deoxycortisol

Glycyrrhizic acid

HO

HO

H

H

O

H

OH

OOH

HOH

H

HO H

O

H

OHO

HOH

HOH H

HO HHO

O

OHO

HOOH

O

H

H H

O

HOOH

O

H

H H

OHO

OH

O

H

H H

hydrocortisone corticosterone 11-deoxycortisol

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

10

1

2

4

5

6

8

9

10

1

2

3

5

6

8

9

10

1

2

3

4

6

8

9

10

1

2

3

4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


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Column selection

guide

MCI GEL™ colum


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and materials

Ion chromatography

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and materials

Column selection

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MCI GEL™ colum


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SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





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MCI GEL™ colum

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Compounds index



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MCI GEL™ colum


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SPE sorbent series

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MCI GEL™ colum

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Compounds index

MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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ns and materials


and materials

Column selection

guide


ns



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

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7

8

9

10 10

1

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4

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1

2

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7

8

9

1

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1

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7

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1

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1

2

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1

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1

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1

2

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4

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8

1

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3

4

5

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7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

37 38

Comparison with an ODS column

Fig. 5-10 Ingredients of medicine

Fig. 5-11 Sulfa drugs

1

2

3

4

0 3020 2515105 min.

1

2

34

0 3020 2515105 min.


ConditionsColumn

Eluent


：MCI GEL™ CMG20/C04　4.6mm I.D.×150mm

：20mM phosphate pH6.8/CH3CN　＝82/18：0.5：45℃：254nm：1.Succinylsulfathiazole　2.Sulfanilamide　3.Sulfathiazole　4.Sulfamerazine

ConditionsColumn

Eluent


：MCI GEL™ CMG20/C04　4.6mm I.D.×150mm：50mM phosphoric acid(pH2.0)/CH3OH　＝60/40：0.5：45℃：254nm：1.4-Dimethylaminoantipyrine　2.Antipyrine　3.Caffeine　4.Aspirin　5.Phenacetin

ConditionsColumn

Eluent


：ODS column　4.6mm I.D.×150mm

：20mM phosphate pH6.8/CH3CN　＝90/10：0.5：45℃：254nm：1.Succinylsulfathiazole　2.Sulfanilamide　3.Sulfathiazole　4.Sulfamerazine

min.

1

2

3

4

5

0 3020 2515105

NN

O

Antipyrine

NN

O

DimethylaminoantipyrineAminopyrine

N

COOH

OAc

Aspirin

NHAc

O

Phenacetin

N

N N

N

O

O

Caffeine

S

HN

OO

N

N

NH2

Sulfamerazine

S

HN

OO

N

S

HN

OOH

O

Succinylsulphathiazole

S

HN

OO

N

S

NH2

sulphathiazole

SH2N

OO

NH2

Sulfanilamide


0 108642 min.min.

2

1

3

4

Fig. 5-15 Water-soluble vitaminsFig. 5-14 Procainamide, Procaine

1

2

0 252015105

O

ON

H2N

Procaine

NH

ON

H2N

Procainamide

NH2

O

N

Vitamin B3

C-NCo3+

N

N-

N

N

N

NO

H2N

O

H2N

O

NH2O

OH

H2N

O

OHN

NH2

O

NH2

O

OP

HO

O-OO

Vitamin B12

NH

NHOOH

N

HO

OS

ONH

O

NH2HO

ONH

O

NH2HO

OH

O

NHN

N

O

NH

ONH

HN

O

HO

O

NH

O

NHOH

ONH

O

NH2

NH

HO

O

NH

H2N

H

0 108642 min.

2

1

3 4

0 40302010 min.

2

1

3

HN

HN O

OHN

HO O

ONH

O

NH2HO

N

OHHO

HO

Vitamin B6

OHOHO

OHHO

OH

Vitamin C

Gly-Tyr

Met Enkephalin

Leu Enkephalin

Angiotensin ll

Fig. 5-12 Peptides Fig. 5-13 Proteins

ConditionsColumn

Eluent



：8mM Na2HPO4 pH7.0/CH3CN　＝85/15：0.5：25℃：254nm：1.Vitamin C　2.Vitamin B6　3.Vitamin B3　4.Vitamin B12

ConditionsColumn

Eluent



：20mM phosphate pH7.2/CH3CN　＝65/35：0.5：45℃：254nm：1.Procainamide　2.Procaine

ConditionsColumn

Eluent



：0.1%TFA/CH3CN　=70/30：0.5：25℃：220nm ：1.Gly-Tyr　2.Met Enkephalin　3.Leu Enkephalin　4.Angiotensin ll

ConditionsColumn

Eluent


：MCI GEL™ CMG20/C04　4.6mm I.D.×150mm：A;0.05%TFA/CH3CN =80/20 B;0.05%TFA/CH3CN =20/80　A→B 30min.linear：0.5：25℃：280nm：1.Ribonuclease A　2.Cytochrome c　3.α-Chymotrypsinogen A

2

3

4

5

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9

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1

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1

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1

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4

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8

9

10

1

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4

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8 8

9

10

1

2

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4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


ns



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

39 40


Pravastatin sodiumSimvastatin

MevastatinMevastatin

Impurity Impurity

SimvastatinPravastatin sodium

Nystatin

Amphotericin BAmphotericin B

Nystatin

Filipin

Filipin

OHO OH

O

HO

ONa

OH

Pravastatin sodium

O

O O

OHO

H

(+)-Simvastatin, Simvastatin

O

O

OHO

O

H

(+)-Compactin; Mevastatin

Fig. 5-16 Pravastatin sodium

CHP20/C10 10μm ODS 10μm

min.0 5 10 15 20 25 min.0 5 10 15 20 25

min.0 5 10 15 min.0 5 10 15


Fig. 5-17 Polyene antibiotics

UV

238

nm (A

U)

UV

238

nm (A

U)

：MCI GEL™ CHP20/C10 (10μm 250 ×4.6mm I.D.) and　ODS (10μm 250 ×4.6mm I.D.) ： A :0.1% Formic acid; B :0.1% Formic acid in AcCN; A/B=60/40;：1.00：25℃：UV305nm for Nystatin, VIS405nm for Amphotericin B and UV340nm for Filipin; ：Pravastatin sodium, Mevastatin and Simvastatin, 1mg/ml each;. ：10μl

ConditionsColumn

Eluent


Sample

Injection

：MCI GEL™ CHP20/C10 (10μm 250 ×4.6mm I.D.) and　ODS (10μm 250 ×4.6mm I.D.) ： A :0.1% Formic acid; B :0.1% Formic acid in AcCN; ： 45%B-95%B over 29min.：1.00：25℃：UV238nm ：Pravastatin sodium, Mevastatin and Simvastatin, 1mg/ml each;.：5μl

ConditionsColumn

Eluent

GradientFlow rateColumn temp.DetectionSampleInjection

OHOH

O

O

OH

OH

OH OH OH OH

OH

H

Filipin

O

O

O

OH OH OH OH

OH

OHOH

OH

O OH

O

O

OHH2N

HO

Nystatin

O

O

OHH2N

HO

HO

HO

OHO O OH OHOH OH OH

OH

O O

Amphotericin B

min.0

4

3

2

1

10 20 30

5



Fig. 5-19 Proteins

Ribonuclease A Conalbumin Ribonuclease A Conalbumin

ConditionsColumn Eluent

Flow rateColumn temp.DetectionSampleInjection

：150 ×4.6mm I.D. ： A :0.1% TFA; B :0.1% TFA in AcCN：1.00：20%B-60%B over 20min;：UV280nm; ：Ribonuclease A and Conalbumin 2mg/ml;. ：10μl

Fig. 5-18 Proteins

：MCI GEL™ CMG20/C10　4.6mm I.D.×250mm：A 0.05% TFA/CH3CN＝80/20　B 0.05% TFA/CH3CN＝30/70　A → B 45min linear gradient：0.5：25℃：280nm：1. Ribonuclease A　2. Cytochrome C　3. Transferrin　4. α-Chymotrypshinogen A　5. β-Lactoglobulin

ConditionsColumn

Eluent


min. min.0 105 15 20 25 0 105 15 20 25

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

10

1

2

4

5

6

8

9

10

1

2

3

5

6

8

9

10

1

2

3

4

6

8

9

10

1

2

3

4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


ns



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

41 42

ConditionsColumn

Eluent


：　

：：：：：：：

MCI GEL™ CMG20/C10ODS 10μm4.6mm I.D.×150mmA) 0.1%TFA, H2OB) 0.1%TFA, AcCN10%B→60%B over 25min.1.040℃230nmGhrelin rat and Ghrelin human ,0.1mmol/l each10μl

Fig. 5-21 Ghrelin


CMG20/C10 10μm ODS 10μm

CHP20/C10 10μm

ODS 10μmCMG20/C10 10μm

Insulin glargine

UV2

30nm

(AU

)U

V230

nm(A

U)

UV2

30nm

(AU

)

UV2

30nm

(AU

)

UV2

30nm

(AU

)

Insulin human recombinant

Insulin glargine Insulin human recombinantInsulin glargine Insulin human recombinant

Ghrelin rat Ghrelin humanGhrelin rat

Ghrelin human

0 5 10 15 20min.

0 5 10 15 20min.

0 2 4 6 8 10 1412 1816 20min.

0 2 4 6 8 10 1412 1816 20min.

0 5 10 15 20min.

ConditionsColumn

Eluent


：MCI GEL™ CHP20/C10 MCI GEL™ CMG20/C10 ODS 10μm 4.6mm I.D.×150mm：A) 0.1%TFA, H2O B) 0.1%TFA, CH3OH：20%B→60%B over 20min.：1.0：40℃：280nm：Insulin Glargine and human recombinant , 1mg/ml each：10μl

Fig. 5-20 Insulin


CMG20/C10 10μm ODS 10μm

TargetU

V210

nm(A

U)

Impurity

Target

Impurity

0 5 10 15 20 25 30 35 40min.

UV2

10nm

(AU

)

0 5 10 15 20 25 30 35 40min.

ConditionsColumn

EluentFlow rateColumn temp.DetectionSampleInjection

：　

：：：：：：

MCI GEL™ CMG20/C10ODS 10μm4.6mm I.D.×150mm0.1%TFA,/CH3CN=68/321.0ml/min40℃210nmSifuvirtide crude(purity 35.5%) 2.1mg/ml0.4ml

Fig. 5-23 Sifuvirtide

Fig. 5-22 Leuprorelin

ConditionsColumn

Eluent


MCI GEL™ CHP20/C10MCI GEL™ CMG20/C10ODS 10μm4.6mm I.D.×150mmA) 0.1%TFA, H2OB) 0.1%TFA, AcCN20%B→60%B over 20min.1.040℃280nmLeuprorelin,LHRH human, LHRH salmon and Buserelin ,1mg/ml each10μl

：　

：：：：：：：

0 2 4 6 8 10 12 14 min. 0 2 4 6 8 10 12 14 min.

Leuprorelin LeuprorelinBuserelin

Buserelin

Leuprorelin Buserelin

LH-RH salmon LH-RH salmon

LH-RH human

LH-RH human

LH-RH salmon

LH-RH human

CMG20/C10 10μm

CHP20/C10 10μm

UV2

30nm

(AU

)

ODS 10μm

UV2

30nm

(AU

)

0 2 4 6 8 10 12 14 min.

UV2

30nm

(AU

)

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

10

1

2

4

5

6

8

9

10

1

2

3

5

6

8

9

10

1

2

3

4

6

8

9

10

1

2

3

4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


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MCI GEL™ colum


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Compounds index

Compounds index

MCI GEL™ colum


ns and m

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Column selection

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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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Compounds index

MCI GEL™ colum


ns and m

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ns and materials


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Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

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Column selection

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Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

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7

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9

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2

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5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

43 44


Fig. 5-25 Nucleotide

Fig. 5-24 ssRNA Ladder Marker

ConditionsColumn

Eluent

Gradient


：MCI GEL™ CMG20/C10 ODS 10μm 4.6mm I.D.×150mm：A)100mM TEAA, H2O B)100mM TEAA, CH3CN：CHP10/C10 ODS 10μm：1.0：40℃：260nm：14-30 ssRNA Ladder Marker [max.0.04mg/ml]：5μl

10%B→40%B over 30min8%B→40%B over 30min

0-4.0min 0%B　　4.0-5.0min 0→30%B　 5.0min-6.0min 30%B　 6.0min-7.0min 30→50%B7.0min-10.0min 50→65%B　　 10.0min-11.0min 65%B　11.0min-　　 0%B

1.Ura，2.Xan，3.Thy，4.Hyp，5.Gua，6.Cyt，7.Ade, 8.Urd，9.Xao，10.dT，11.Ino，12.Guo，13.Cyd，14.Ado

B)20 mM Na2HPO4 / 100 mM NaClO4 / 30% ACN

ConditionsColumn

Eluent

Gradient


：MCI GEL™ CHK40/C04 4.6mm I.D.×150mm：A)19 mM H3PO4 / 1 mM NaH2PO4 / 5.0% ACN ：：0.8：50℃：UV260nm：：20μl

tR / mim

inte

nsity

/ -

Ura

Urd

Xan

Xao

Ino Th

y

dT

Hyp

Guo

Gua

Ade

Cyd

Cyt

Ado

0 2 4 6 8 10 12 14

0 5 10 15min.

ODS 10μm 40℃

CHP20/C10 40℃

CHP20/C10 60℃

UV

260n

m(A

U)

18 base

14 base22 base

26 base30 base



LinaloolUV2

10nm

(AU

)

0 2 864 10分

CMG20/C10 10μm

ConditionsColumn


Injection

：

：：：：：

：

Fig. 5-26 Linalool

0 5 10 15 20min.

CMG20/C10 10μm

UV2

10nm

(AU

) 12

3

4 5

0 5 10 15 20min.

ODS 10μm

UV2

10nm

(AU

)

1

2

3

4

5

ConditionsColumn

EluentFlow rateColumn temp.DetectionSampleInjection

：MCI GEL™ CMG20/C10 4.6mm I.D.×150mm：Hexan/Ethanol=99.5/0.5：1.0：40℃：210nm：Coriander：10μl

MCI GEL™ CMG20/C10ODS 10μm4.6mm I.D.×150mmHexan/Ethanol=99.5/0.51.040℃210nm1:Linalyl Acrtate 1mg/ml2:Linalool 1mg/ml3:β-Citronellool 1mg/ml4:Nerol 0.5mg/ml5:Geraniol 0.5mg/ml10μl

Fig. 5-27 Coriander

2

3

4

5

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9

10

1

3

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10

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10

1

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10

1

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9 9

10

1

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4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

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MCI GEL™ colum


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MCI GEL™ colum


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Ion chromatography

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SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





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MCI GEL™ colum

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Compounds index



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MCI GEL™ colum


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MCI GEL™ colum

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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum


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Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

45 46


(TritonX-100)

min. min.

Fig. 5-32 ODS-1HU (ODS)Fig. 5-31 C18-alkylated aliphatics CHPOD/C04

ConditionsColumn


：MCI GEL™ CHPOD/C04　4.6mm I.D.×150mm：50vol%CH3CN：0.50：40℃：254nm：Triton X-100 (Polyoxyethylene octyl phenyl ether) 1% each 10μL

ConditionsColumn


：MCI GEL™ ODS-1HU　4.6mm I.D.×250mm：50vol%CH3CN：1.00：40℃：254nm：Triton X-100 (Polyoxyethylene octyl phenyl ether) 1% each 10μL

n=9.6 n=9.6

Fig. 5-33　Application data of Nucleic base/Nucleoside and Beer

0-0.7min 0%B 0.7-3.0min 0→40%B 3.0-3.2min 40%B3.2-3.5min 40→80%B　3.5-8.0min 80%Β 8.0min- 0%B

ConditionsColumn

Eluent

Gradient

Flow rateColumn tempDetectionInjection

：MCI GEL™ CHK45/C05　4.6mm I.D.×150mm：A）8 mM H3PO4

B）10 mM H3PO4 /30% ACN

：1.3：45℃：UV(260nm)：20μl

1211109876543210

1211109876543210

1211

Draft Beer

Carbohydrate-free "happoshu-type" beer

A new category of beer that contains 85% less purine

109876543210

Analysis of various category beer

Urd

Ura

dT

Cyd

Urd

Urd

Ura

dT Cyd

Ino

Xan

Guo

Gua

dA Ade

Ino

Ura Ino

Xan

dT Xan

Guo

Guo

Gua

Gua

dA

Ade

0

Inte

nsity

/-

Ino

Ura

Xan

Hyp

Xao

Urd

AMP

UM

P

Cvd

Guo

dT

GD

P

Cvt

dCG

ua

dA

Ade

Ado

tR / min2 4 6 8 10 12



(Polyphenon 60)Fig. 5-30 Styrene Divinylbenzene CHP20/C04Fig. 5-29 Modified Styrene Divinylbenzene

CHP07/C04ConditionsColumn


：MCI GEL™ CHP20/C04　4.6mm I.D.×150mm：CH3OH/10mM-Acetic acid＝60/40：0.46：60℃：280nm：Polyphenon 60(10mg/ ) each 10μL

ConditionsColumn


：MCI GEL™ CHP07/C04　4.6mm I.D.×150mm：CH3OH/10mM-Acetic acid＝60/40：0.46：60℃：280nm：Polyphenon 60(10mg/ ) each 10μL


Fig. 5-28 Application data of CHK40/C04：Sepatation of Sartans

N

O

HO

O

NH

N

NN

Valsartan

N

ON

HO O

NHNNN

Candesartan

O

N

N

HN NN N

Irbesartan

NN

HO

Cl NHNNN

Losartan

ConditionsColumn

Eluent

Gradient


Injection

：MCI GEL™ CHK40/C04 4.6mm I.D.×150mm：：

：1.0：50℃：UV：Candesartan(CAN),Losartan(LOS), Valsartan(VAL), Irbesartan(IRB) ：20μl

A）10 mM Na H↓ 2 PO↓ 4 +0.2 mM Na↓ 2 HPO↓ 4 (25%ACN)B）10 mM Na H↓ 2 PO↓ 4 +1.0 mM Na↓ 2 HPO↓ 4 (40%ACN)0.5min 0%B 0.5-2.0min 50%B2.0min- 90%Β

min.min.

min.642

CAN

LOS

VAL

IRB

0

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

10

1

2

4

5

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10

1

2

3

5

6

8

9

10

1

2

3

4

6

8

9

10

1

2

3

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5

8 8

9

10

1

2

3

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10

1

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3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum

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Compounds index

Compounds index

Compounds index

Compounds index



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columns and m


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2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

47 48

●CHP material series

Polymethacrylate

Styrene Divinylbenzene

CHP20/P20

CHP20/P30

CHP20/P50

CHP20/P70

CHP20/P120

20

30

50

70

120

CHP07/P120

CHP50/P20

CHP50/P30

CSP50/P10

20

30

10

120

drug compoundsPeptidesProteins

CMG20/P10

CMG20/P30

CMG20/P150

10

30

150

CHP20/C04

CHP20/C10

CHP20/C10

CMG20/C04

CMG20/C10

CHP07/C04

CHP07/C10

-

Product nameBase polymer

None

None

Br

Functionalgroup

Mainapplication

EquivalentHPLC column

Particlesize[μm]

25

45

25

25

25

Porediameter

[nm]


5

CHP material series Analytical and preparative chromatography columns and materials for pharmaceutical applications

�M�C�I� �G�E�L�™� �C�H�P� �m�a�t�e�r�i�a�l� �s�e�r�i�e�s� �a�r�e� �c�h�r�o�m�a�t�o�g�r�a�p�h�y� �m�a�t�e�r�i�a�l�s� �o�f� �p�o�r�o�u�s� �t�y�p�e� �p�o�l�y�m�e�r�s�.

�B�e�c�a�u�s�e� �p�o�l�y�m�e�r�i�c� �m�a�t�e�r�i�a�l�s� �a�r�e� �c�h�e�m�i�c�a�l�l�y� �s�t�a�b�l�e�,� �w�i�d�e� �p�H� �r�a�n�g�e�,� �f�r�o�m� �a�c�i�d�i�c� �t�o� �a�l�k�a�l�i�n�e� �e�l�u�e�n�t�s� �a�r�e� �a�b�l�e� �t�o� �b�e� �a�p�p�l�i�e�d� �t�o� �M�C�I� �G�E�L�™� �C�H�P� �m�a�t�e�r�i�a�l� �s�e�r�i�e�s�.

�M�C�I� �G�E�L�™� �C�H�P�5�0� �s�e�r�i�e�s� �a�n�d� �C�H�P�2�0� �s�e�r�i�e�s� �a�r�e� �b�o�t�h� �S�T�/�D�V�B� �p�o�l�y�m�e�r�s�,� �b�u�t� �t�h�e�y� �d�i�f�f�e�r�e�n�c�e�s� �i�n� �p�o�r�o�s�i�t�y�.� � �P�o�r�e� �s�i�z�e� �o�f� �C�H�P�2�0� �s�e�r�i�e�s� �i�s� �f�a�i�r�l�y� �l�a�r�g�e�r� �t�h�a�n� �t�h�a�t� �o�f� �C�H�P�5�0� �s�e�r�i�e�s�.� � �A�p�p�r�o�p�r�i�a�t�e� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l� �c�a�n� �b�e� �s�e�l�e�c�t�e�d� �i�n� �a�c�c�o�r�d�a�n�c�e� �w�i�t�h� �m�o�l�e�c�u�l�a�r� �s�i�z�e� �o�f� �i�n�j�e�c�t�i�o�n� �s�a�m�p�l�e�s�.

Application data of CHP 50

Fig. 5-36 Extract of green tea leaves

0 5 10 15 20 25 30 min.

min.

1

2

3

MeOOC COOMe

Phthalic acid dimethyl ester

PrOOC COOPr

Phthalic acid dipropyl ester

EtOOC COOEt

Phthalic acid diethyl ester

0

20

40

60

80

100

-0.1

0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

0.9

0 1 2 3 4 5 6 7

MeO

H (%

)

UV

280

nm (A

U)

BV

ConditionsColumnEluent

Flow rateDetectionSample

：MCI GEL™ CHP50/P20, 32mmI.D×465mm：0−185min, CH3OH:0.01M Acetic acid(35:65)　185−350min, CH3OH:0.01M Acetic acid(50:50)：7.48：280nm：extract of green tea leaves, injection volumn 18.7　1. Epigallocatechin　2. Catechin　3. Epicatechin　4. Epigallocatechin gallate　5. Gallocatechin　6. Epicatechin gallate　7. Caffeine

CHP50/P20(20μm)

CHP50/P30(30μm)

CHP20/P50(50μm)

CHP20/P70(70μm)

CHP20/P120(120μm)

Penicllin V

Penicllin G

6-Aminopenicillanic acid

O

ON

SCONH

COONa

CH3

CH3

HH

ON

SCONH

COONa

CH3

CH3

HH

ON

S

COONa

CH3

CH3

H2NHH

1

2

3

1

1

1

1

22

2

2

3 3

3

3

Fig. 5-34 Phthalic acid esters Fig. 5-35 Penicilin antibiotics

ConditionsColumnEluentFlow rateColumn temp.DetectionSample

Injection

：MCI GEL™ CHP50/P20, 10mml I.D.×250mmL：H2O/CH3CN=20/80：0.75：25℃：254nm,：1.Dimethyl phthalate 0.5%　2.Dipropyl phthalate 0.5%　3.Dibutyl phthalate 0.5%：100μl

ConditionsColumnEluentFlow rateColumn temp.DetectionSample

Injection

：MCI GEL™ CHP series, 10mml I.D.×250mmL：CH3OH/0.05M Phosphate buffer (pH8.0)=60/40：2.18：25℃：254nm,：1.6-Aminopenicillanic acid 1000ppm　2.Penicillin G 1000ppm　3.Penicillin V 1000ppm：100μl

2

3

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10

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10

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6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


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and materials

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columns and m


ns and m

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MCI GEL™ colum


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MCI GEL™ colum


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SPE sorbent series

SPE sorbent series

SPE sorbent series





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MCI GEL™ colum


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MCI GEL™ colum


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MCI GEL™ colum








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Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



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columns and m


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2

3

4

5

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7

8

9

1

3

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7

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9

10 10

1

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1

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9

1

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9

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9

1

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9

1

2

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9 9

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8

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7

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9

1

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8

1

2

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4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

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及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

49 50

Application data of CHP 20

ConditionsColumn

Eluent


：MCI GEL™ CHP20/P30　32mm I.D.×490mm：CH3OH + 1% Acetic acid = 60 + 40 (vol.)：7.88：270 nm：Extract of senna pulv., partially purified by Diaion HP20 injected amount : 39.4

Fig. 5-38 Elution profile of senna pulv. extract separated on MCI GEL™ CHP20/P30

Fig.5-37 Senna pulv. extract

0 105 2015 3025 4035 5045 60 min 55 0 105 2015 3025 4035 5045 60 min 55 0 105 2015 3025 4035 5045 60 min 55

Sennoside APurity: 90.3%,

Recovery: 60.9%

Conditions

Column

EluentFlow rateDetectionSample

Chromatogram A：MCI GEL™ CHP20/C10　4.6mm I.D.×250mm：CH3OH/1% Acetic acid = 60/40 (vol.) ：0.5：270nm：Extract of senna pulv. 10μL

Chromatogram B：MCI GEL™ CHP20/P20　10.0mm I.D.×250mm：CH3OH/1% Acetic acid = 60/40 (vol.) ：2.4：270nm：Extract of senna pulv. 80μL

Chromatogram C：MCI GEL™ CHP20/P30　10.0mm I.D.×250mm：CH3OH/1% Acetic acid = 60/40 (vol.) ：2.4：270 nm：Extract of senna pulv. 80μL

Sennoside ASennoside B

Sennoside B

Sennoside A

Sennoside B

Sennoside A

Sennoside B

Sennoside A

（C）CHP20/P30 (30μm) （B）CHP20/P20 (20μm) （A）CHP20/C10 (10μm)

0 60 120 180 240 300 min


0 60 120 180 min

Fig. 5-39 Elution profile of gardenia fructus extract separated on MCI GEL™ CHP20/P30

Fig. 5-40 Capsicin

ConditionsColumn EluentFlow rateColumn temp.DetectionSampleInjection

：MCI GEL™ CMG20/C10, 4.6mmI.D.×250mm MCI GEL™ CMG20/P150, 20mmI.D.×500mm：Hexane/EtOH=87.5/12.5;：1.00 for CMG20/C10, 2.36ml/min for CMG20/P150;：25℃：UV 280nm：Capsici Fructus extract;：20ml for CMG20/C10, 1.5ml for CMG20/P150.

ConditionsColumn

Eluent


：MCI GEL™ CHP20/P30　32mm I.D.×490mm：CH3OH + H2O = 65 + 35 (vol.)：7.88：420 nm：Extract of gardenia fructus injected amount : 39.4

CMG20/C10 (10μm) CMG20/P150 (150μm)

0

UV

280

nm (A

U)

5 10 15min

20 25 30 0

UV

280

nm (A

U)

80 160 240min

320 400 480

CapsicinDihydrocapsaicin CapsicinDihydrocapsaicin

2

3

4

5

6

8

9

10

1

3

4

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6

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9

10

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10

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10

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10

1

2

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4

5

6

10 10

1

2

3

4

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8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

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columns and m


ns and m

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MCI GEL™ colum


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MCI GEL™ colum


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SPE sorbent series

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2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

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9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

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1

2

3

4

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1

2

3

4

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8

1

2

3

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2

3

4

5

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8

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2

3

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固相吸着剤

51 52


Fig. 5-44 Elution profile of tocopherol and tocotrienol in preparative scale

min.0 20 40 60 80 100 120 140 160 180 200

1

44

77 31 3

Fig. 5-41 Vitamin E in Rice Bran Oil

ConditionsColumn

EluentFlow rateDetectionSampleInjection

：MCI GEL™ CMG20/C10　4.6mm I.D.×150mm：Hexane-EtOH = 98/2 (vol.)：0.5：295nm：Rice Bran Oil, 50：10μL

Fig. 5-42 Elution profile of Rice Bran Oil in preparative scaleConditionsColumn

EluentFlow rateDetectionSampleInjection

：MCI GEL™ CMG20/P30　20mm I.D.×500mm：Hexane/C2H5OH = 98/2 (vol.)：4.7：295 nm：Rice Bran Oil, 50：1260μL

0.9 1.1

1

3

5 7

6 8

4

2

1.3 1.5BV

1.7 1.9 2.1

Fig. 5-43 Mixture of tocopherol and tocotrienol : Comparison with silica gel column

min.

Silica gel

CMG20/C10

10 20 30 40

8

8

7

7

1

1

3

4

4

5

5

(2) (6)

2 6

ConditionsColumn

Eluent


：1. Silica gel 5SIL, 4.6mmI.D.×250mm 2. MCI GEL™ CMG20/C04, 4.6mmI.D.×150mm：1. Hexane/EtOH = 99/1 2. Hexane/EtOH = 98/2 ：1.0：25℃：UV 292nm：Mixture of tocopherol and tocotrienol：10μl( 1mg/mL )

ConditionsColumnEluentFlow rateColumn temp.DetectionSampleInjection

：MCI GEL™ CMG20/P150, 41.2mmI.D.×550mm, ×4：Hexane/EtOH = 90/10：49.0 (SV=1.0)：25℃：UV 292n：Mixture of tocopherol and tocotrienol：150 mL ( 50g/L )

TocotrienolTocopherol

5. α-tocotrienol6. β-tocotrienol7. γ-tocotrienol8. δ-tocotrienol

R1CH3CH3HH

R2CH3H

CH3H

R3CH3CH3CH3CH3

1. α-tocopherol 2. β-tocopherol 3. γ-tocopherol 4. δ-tocopherol

R1CH3CH3HH

R2CH3H

CH3H

R3CH3CH3CH3CH3

min.0 6 12 18 24 30 36

CH3

CH3CH3CH3CH3

R1

R2

R3

O

HO

CH3

CH3CH3CH3CH3

R1

R2

R3

O

HO

Tocotrienolgroup

Tocopherolgroup

CRS10W 4.6×50 CRS15W 4.6×50

Chiral separation columns

○Chiral separation columns MCI GEL™ CRS10W （DLAA）MCI GEL™ CRS15W （LDAA）

●Separation mechanism

Separation mechanismFig. 6-1 DL-IsoleucineApplication of CRS10W

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●Separation performance

●USP L32 column

O

O

HONH

O N RR

allo-L

L

allo-D

D

20 400 min.

�1�.

�2�.�

�3�.�

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Cu2＋

sample moleculeopticalactivated ligand

ligandexchange

hydrophobicinteraction

non-polar surface

base material

6 Chiral separation columns

Separation mechanism and performance of MCI GEL™ CRS series

2mM CuSO4/H2O0.5

MCI GEL™ column USPParticle size (μm)Column dimensions

MCI GEL™ CRS10W

MCI GEL™ CRS15W

4.6×50mm

4.6×50mm

L32

L32

3

3



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


ns



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

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4

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7

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9

10 10

1

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1

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1

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8

1

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7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

2

3

4

5

6

8

9

10

1

3

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5

6

8

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10

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2

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10

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10

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10

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8 8

9

10

1

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9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

53 54

Fig. 6-2 Separation of amino acids mixture

For all chromatograms, column temperature is room temperature and wave length is 254nm. All eluents are CuSO4 aqueous solution except for Fig. 6-9 and Fig. 6-10.

D isomers elute ahead of L isomers.

Fig. 6-3 Separation of amino acids mixture

Fig. 6-4 Separation of DL-Ser.

D isomers elute ahead of L isomers.0.1mM CuSO4,0.5

Fig. 6-5 Separation of DL-aspartic acid

2mM CuSO4,0.5

Fig. 6-6 Separation of DL-glutamic acid

Fig. 6-8 Separation of DL-lysine

Fig. 6-7 Separation of DL-histidine

2mM CuSO4,1.0

0.1mM CuSO4,0.5

0.1mM CuSO4,0.2

Fig. 6-9 Separation of DL-phenylalanine2mM CuSO4/CH3OH＝85/15(vol)1

Fig. 6-10 Separation of DL-tryptophan

Fig. 6-12 Durability testFig. 6-11 Separation of DL-lactic acid

2mM CuSO4/CH3OH＝85/15(vol)1

2mM CuSO4,0.5

0.5mM CuSO4,1.0Column temp.　　：ambientDetection：254nm

Tyr

Leu

Nleu

Met

ProVal

NVal

D L

Eth Phe

40 60200 min. 40200 min.

200 min.

200 min.

200 min.200 min.20

LD LDLD

LD

0 min.

200

D L D L

D

L

D-Pro

D-Val

L-ProL-Val

min. 600 min. 200 min. 200 min. 200 min.

The sample was continuously injected 800 times for approximately 500 hrs. Changes of retention times and separation ability are not observed.

Application data of CRS10W

Fig. 6-13 Separation of DL-α-Phenylglycine

：MCI GEL™ CRS10W 4.6mm I.D.×50mm：2mM CuSO4/CH3OH＝85/15：1.0：25℃：254nm：1. D-α-Phenylglycine　2. L-α-Phenylglycine

Fig. 6-14 Separation of methionine and acetylmethionine

：MCI GEL™ CRS10W 4.6mm I.D.×50mm：2mM CuSO4/CH3CN＝90/10：1.0：25℃：254nm：1. D-Met　2. L-Met　3. Acetyl-D-Met　4. Acetyl-L-Met

Fig. 6-16 Separation of diaminopimelic acid

10

3

2

1

20 min.604030 50

5

4

3

2

1

10 min.10

2

1

20 min.



：MCI GEL™ CRS10W 4.6mm I.D.×50mm：2mM CuSO4

：0.5：25℃：254nm：


：MCI GEL™ CRS10W 4.6mm I.D.×50mm：0.4mMCuSO4

：1.0：ambient：UV 254nm：D/L Aspartic acid

ConditionsColumn EluentFlow rateTemp.DetectionSample


Fig. 6-15 D/L-Aspartic acid

1050 2520 353015

1. D,D-2,6-Diaminopimelic acid2. meso-2,6-Diaminopimelic acid3. L,L-2,6-Diaminopimelic acid

D

L

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

10

1

2

4

5

6

8

9

10

1

2

3

5

6

8

9

10

1

2

3

4

6

8

9

10

1

2

3

4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


ns



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

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8

9

1

2

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5

6

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9

1

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7

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9

1

2

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9

1

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2

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9 9

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8

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4

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8

1

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4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

55 56

Fig. 6-17 Separation of 2-hydroxy carboxylic acids

Fig. 6-18 Separation of 2-hydroxy carboxylic acids

03

2

1

min.5010 20 30 40

4

5

6

0

3

2

1

min.4010 20 30

4

5

6 7

8


：MCI GEL™ CRS10W 4.6mm I.D.×50mm：2mM CuSO4/CH3CN＝90/10：1.0：ambient：254nm：1,2＝D,L-Lactic acid　3,4＝D,L-2-Hydroxy-n-butyric acid　5,6＝D,L-α-Hydroxy-n-valeric acid　7,8＝D-,L-α-Hydroxy isocaproic acid


：MCI GEL™ CRS10W 4.6mm I.D.×50mm：2mM CuSO4/CH3CN＝90/10：1.0：ambient：254nm：1,2＝D,L-p-Hydroxymandelic acid　3,4＝D,L-m-Hydroxymandelic acid　5,6＝D,L-Mandelic acid


Fig. 6-19 D/L Alanine Fig. 6-20 DL-P-Hydroxyphenylglycine

：MCI GEL™ CRS10W 4.6mm I.D.×50mm：0.1mMCuSO4

：1.0：30℃：UV 254nm：D/L Alanine


：MCI GEL™ CRS10W 4.6mm I.D.×50mm：2mMCuSO4:MeOH＝85:15：1.0：30℃：UV 254nm：DL-P-ydroxyphenylglycine


D

L

D L

7.55.02.50.0 7.55.02.50.0

Fig. 6-21 Separation of DL-alanine

Fig. 6-22 Analysis of a trace of L-lactic acid in 50 ppm D-lactic acid

CRS15W CRS10W

CRS15W CRS10W

The CRS15W is recommended for analysis of a trace of L-isomer in a principal D-isomer when the CRS10W does not provide an adequate chromatogram.

0.1mM CuSO4

0.5

2mM CuSO4

0.5

0 10 0 10

L

D

←L

D

L

D

STAR

T

STO

P

10

STAR

T

STO

P

10

min. min.

min. min.

L

D

Comparison data of CRS10W and CRS15W

2

3

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5

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9

10

1

3

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5

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10

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10

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3

5

6

8

9

10

1

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4

6

8

9

10

1

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4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


ns



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

57 58

Notes

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

Orn•HCI

Lys•HCI

Ala

His•HCI

Ser

Thr

Cit

Hyp

Pro

Val

Nval

Asp

Glu

Ileu(DL)

Ileu(allo)

Leu

Nleu

Met

Tyr

Eth

Phe

0.1

0.1

0.1

0.1

0.1

0.1

0.5

1.0

1.0

1.0

1.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

0.2

0.2

0.5

0.5

0.5

0.5

0.5

0.2

1.0

1.0

1.0

0.5

1.0

0.5

0.5

1.0

1.0

1.0

1.0

1.0

1.0

6.8

7.7

11.0

10.5

10.1

11.3

10.4

23.8

7.3

8.9

11.5

13.2

16.2

30.4

21.9

14.6

24.1

10.3

22.5

26.4

37.8

＜1

＜1

1.4

1.7

1.0

1.3

2.3

1.1

4.5

5.0

4.7

0.8

2.3

6.5

6.0

4.6

6.5

2.6

5.3

5.0

6.3

1.26

1.45

1.39

1.63

1.25

1.29

1.75

1.23

2.13

2.04

2.07

1.18

1.54

2.14

1.97

1.97

2.16

1.64

1.85

1.69

1.84

Amino acidsCuSO4 aq. soln.

[mM]Flow rate[ ]

Retention time; L-isomers

[min]

Separationfactor

[α]

Separationrate[Rs]

�1�.�2�.�3�.

�4�.

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�I�t� �w�i�l�l� �t�a�k�e� �h�o�u�r�s� �f�o�r� �e�q�u�i�l�i�b�r�i�u�m� �b�e�t�w�e�e�n� �l�i�g�a�n�d� �o�f� �s�t�a�t�i�o�n�a�r�y� �p�h�a�s�e� �a�n�d� �c�o�p�p�e�r� �i�o�n� �o�f� �e�l�u�e�n�t�.� �T�w�o� �t�o� �t�h�r�e�e� �h�o�u�r�s� �o�f� �c�o�n�d�i�t�i�o�n�i�n�g� �t�h�e� �c�o�l�u�m�n� �w�i�t�h� �t�h�e� �e�l�u�e�n�t� �i�s� �a�d�v�i�s�e�d� �b�e�f�o�r�e� �s�a�m�p�l�e� �i�n�j�e�c�t�i�o�n� �o�r� �a�f�t�e�r� �c�h�a�n�g�i�n�g� �c�o�n�c�e�n�t�r�a�t�i�o�n� �o�f� �C�u�S�O�4� �o�f� �e�l�u�e�n�t�.�F�o�r� �a�c�i�d�i�c� �a�m�i�n�o� �a�c�i�d�s�,� �h�i�g�h�e�r� �C�u�S�O�4� �c�o�n�c�e�n�t�r�a�t�i�o�n� �o�f� �e�l�u�e�n�t� �p�r�o�v�i�d�e�s� �b�e�t�t�e�r� �r�e�s�o�l�u�t�i�o�n�.�F�o�r� �w�e�a�k�l�y� �r�e�t�a�i�n�e�d� �h�y�d�r�o�p�h�i�l�i�c� �a�m�i�n�o� �a�c�i�d�s�,� �l�o�w� �f�l�o�w� �r�a�t�e� �(�0�.�2�-�0�.�5� �m�L�/�m�i�n�)� �y�i�e�l�d�s� �b�e�t�t�e�r� �r�e�s�o�l�u�t�i�o�n�.�P�e�a�k� �a�r�e�a� �m�a�y� �d�e�c�r�e�a�s�e� �w�i�t�h� �c�o�n�t�i�n�u�o�u�s� �i�n�j�e�c�t�i�o�n� �o�f� �s�a�m�p�l�e�s�,� �w�h�e�n� �t�h�e� �c�o�n�c�e�n�t�r�a�t�i�o�n� �o�f� �a�m�i�n�o� �a�c�i�d�s� �i�n� �s�a�m�p�l�e� �s�o�l�u�t�i�o�n� �i�s� �m�u�c�h� �h�i�g�h�e�r� �t�h�a�n� �t�h�a�t� �o�f� �C�u�S�O�4� �i�n� �t�h�e� �e�l�u�e�n�t�.�P�l�e�a�s�e� �b�e� �c�a�r�e�f�u�l� �n�o�t� �t�o� �f�l�o�w� �b�o�t�h� �w�a�t�e�r� �s�o�l�u�b�l�e� �o�r�g�a�n�i�c� �s�o�l�v�e�n�t�s� �(�C�H�3�C�N�,� �C�H�3�O�H�,� �e�t�c�)� �a�n�d� �n�o�n� �w�a�t�e�r� �s�o�l�u�b�l�e� �o�r�g�a�n�i�c� �s�o�l�v�e�n�t�s� �(�n�-�h�e�x�a�n�e�,� �c�h�l�o�r�o�f�o�r�m�,� �e�t�c�)� �i�n�t�o� �t�h�e� �c�o�l�u�m�n�.� �T�h�e� �c�o�l�u�m�n� �w�i�l�l� �b�e� �f�a�t�a�l�l�y� �d�a�m�a�g�e�d� �a�n�d� �w�i�l�l� �n�e�v�e�r� �s�e�p�a�r�a�t�e� �o�p�t�i�c�a�l� �i�s�o�m�e�r�s�.� �P�l�e�a�s�e� �b�e� �p�a�r�t�i�c�u�l�a�r�l�y� �c�a�r�e�f�u�l� �i�f� �H�P�L�C� �e�q�u�i�p�m�e�n�t� �i�s� �u�s�e�d� �t�o�g�e�t�h�e�r� �w�i�t�h� �R�P� �m�o�d�e� �a�n�d� �N�P� �m�o�d�e�.�P�l�e�a�s�e� �d�o� �n�o�t� �u�s�e� �a�c�i�d� �o�r� �a�l�k�a�l�i� �s�o�l�u�t�i�o�n�s� �t�o� �a�d�j�u�s�t� �p�H� �o�f� �e�l�u�e�n�t�.� �A�n�d� �a�l�s�o� �d�o� �n�o�t� �u�s�e� �b�u�f�f�e�r� �s�o�l�u�t�i�o�n�s�.� �T�h�e�s�e� �s�o�l�u�t�i�o�n�s� �m�a�y� �c�a�u�s�e� �f�o�r�m�i�n�g� �p�r�e�c�i�p�i�t�a�t�i�o�n�,� �h�e�n�c�e� �c�a�u�s�e� �o�f� �b�l�o�c�k�a�g�e� �o�f� �t�h�e� �c�o�l�u�m�n�.�F�o�r� �s�t�r�o�n�g�l�y� �r�e�t�a�i�n�e�d� �h�y�d�r�o�p�h�o�b�i�c� �a�m�i�n�o� �a�c�i�d�s�,� �a�d�d�i�t�i�o�n� �o�f� �C�H�3�C�N� �o�r� �C�H�3�O�H� �i�n� �t�h�e� �e�l�u�e�n�t� �e�n�a�b�l�e�s� �f�a�s�t�e�r� �e�l�u�t�i�o�n�.� �T�h�e� �c�o�n�c�e�n�t�r�a�t�i�o�n� �o�f� �t�h�e�s�e� �o�r�g�a�n�i�c� �s�o�l�v�e�n�t�s� �s�h�o�u�l�d� �b�e� �b�e�l�o�w� �1�5� �v�/�v�%�.�D�O�P�A� �a�n�d� �o�t�h�e�r� �n�o�n�-�p�o�l�a�r� �a�m�i�n�o� �a�c�i�d�s� �w�i�l�l� �b�e� �s�t�r�o�n�g�l�y� �a�d�s�o�r�b�e�d� �o�n� �t�h�e� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l� �a�n�d� �w�i�l�l� �c�a�u�s�e� �c�o�n�t�a�m�i�n�a�t�i�o�n� �o�f� �t�h�e� �c�o�l�u�m�n�.�R�e�g�e�n�e�r�a�t�i�o�n� �o�f� �c�o�n�t�a�m�i�n�a�t�e�d� �c�o�l�u�m�n� �i�s� �d�i�f�f�i�c�u�l�t�.

Examples of chromatographic conditions and datas

�F�o�r� �a� �p�r�e�t�r�e�a�t�m�e�n�t� �o�f� �a�n�a�l�y�t�i�c�a�l� �s�a�m�p�l�e�,� �w�e� �p�r�o�v�i�d�e� �v�a�r�i�o�u�s� �S�P�E� �s�o�r�b�e�n�t�s� �w�i�t�h� �v�a�r�i�o�u�s� �c�h�e�m�i�c�a�l� �s�t�r�u�c�t�u�r�e�,� �h�y�d�r�o�p�h�o�b�i�c�i�t�y�,� �a�n�d� �m�i�c�r�o�-�p�o�r�e� �s�i�z�e�s�.� �Y�o�u� �c�a�n� �s�e�l�e�c�t� �o�u�r� �S�P�E� �s�o�r�b�e�n�t�s� �d�e�p�e�n�d�i�n�g� �o�n� �y�o�u�r� �m�o�l�e�c�u�l�e� �n�a�t�u�r�e�.

7

�C�H�P�8�5�/�P�1�2�0�,�C�H�P�8�7�/�P�1�2�0�,�C�H�P�O�D�/�P�3�0�:� �S�P�E� �s�o�r�b�e�n�t�s� �w�i�t�h� �a� �c�o�n�t�r�o�l�l�e�d� �m�i�c�r�o�-�p�o�r�e� �s�i�z�e�,� �h�i�g�h� �p�e�r�f�o�r�m�a�n�c�e� �s�m�a�l�l� �m�o�l�e�c�u�l�e� �a�d�s�o�r�p�t�i�o�n� �e�x�c�e�p�t� �l�a�r�g�e� �m�o�l�e�c�u�l�e� �m�i�x�t�u�r�e�,� �l�i�k�e� �p�r�o�t�e�i�n�s�.�C�S�P�8�0�0�:� �S�P�E� �s�o�r�b�e�n�t�s� �w�i�t�h� �h�i�g�h� �c�o�n�c�e�n�t�r�a�t�i�o�n� �r�a�t�i�o� �a�n�d� �h�i�g�h� �r�e�c�o�v�e�r�y�,� �e�x�c�e�l�l�e�n�t� �f�o�r� �e�n�r�i�c�h�m�e�n�t� �t�r�a�c�e� �o�r�g�a�n�i�c� �c�o�m�p�o�u�n�d�s� �a�n�d� �n�o�n�-�i�o�n�i�c� �s�u�b�s�t�a�n�c�e�s� �s�u�c�h� �a�s� �t�r�i�c�h�l�o�r�o�e�t�h�y�l�e�n�e� �f�r�o�m� �e�n�v�i�r�o�n�m�e�n�t�a�l� �w�a�t�e�r�.�T�h�e�s�e� �S�P�E� �s�o�r�b�e�n�t�s� �a�r�e� �t�o� �p�r�e�p�a�r�e� �s�a�m�p�l�e�s� �f�o�r� �m�u�t�a�g�e�n�i�c�i�t�y� �s�t�u�d�y� �o�r� �G�C�/�M�S� �a�n�a�l�y�s�i�s�.�S�F�P�0�8�/�P�2�5�:� �S�P�E� �s�o�r�b�e�n�t�s� �d�e�d�i�c�a�t�e�d� �f�o�r� �s�m�a�l�l� �d�r�u�g� �m�o�l�e�c�u�l�e�s� �e�x�t�r�a�c�t�i�o�n�.�S�u�p�e�r�i�o�r� �p�u�r�i�t�y� �o�f� �t�h�i�s� �S�P�E� �e�x�t�r�a�c�t�s� �o�f�f�e�r�s� �e�a�s�i�e�r� �a�n�d� �f�a�s�t�e�r� �s�a�m�p�l�e� �p�r�e�p�a�r�a�t�i�o�n�.�C�H�L�1�0�P�,�C�H�L�2�0�P�,�C�L�B�2�0�P�:� �S�P�E� �s�o�r�b�e�n�t�s� �f�o�r� �r�a�r�e� �e�a�r�t�h� �m�e�t�a�l�s� �t�h�a�t� �c�o�n�t�a�i�n�s� �c�h�e�l�a�t�i�n�g� �f�u�n�c�t�i�o�n�a�l� �g�r�o�u�p�.� �C�L�B�1�0�P�:� �S�P�E� �s�o�r�b�e�n�t�s� �f�o�r� �b�o�r�a�t�e�,� �a�r�s�e�n�i�c� �a�n�d� �s�e�l�e�n�i�u�m� �i�o�n�s� �t�h�a�t� �c�o�n�t�a�i�n�s� �g�l�u�c�a�m�i�n�e� �g�r�o�u�p�s� �o�n� �h�i�g�h� �p�o�r�o�u�s� �S�T�/�D�V�B� �m�a�t�r�i�x�.

・

・

・

・

Material list

Solid phase extraction sorbentsSPE sorbent series Solid phase extraction sorbents

CHP85/P120

CHP87/P120

CHPOD/P30

Small molecules extraction

CSP800Enrichment of trace of organic compounds

SFP08/P25 Small molecules extraction

middle

small

large

middle

middle

full range

full range

2～12

full range

full range

120

120

30

120

25

Typical Application

CHL10P

CHL20P

CLB10P

Iminodiaceteic acid

Polyamine

Glucamine

＞1.5

＞1.8

＞1.0

2-6

2-6

＞3

120

120

120

Name

Typical ApplicationName

Metal Extraction

Metal Extraction

ExtractionBron Removal

Effective pH range

pH rangePore size

880-940

820-910

340-380

790-920

＞1000

Mean particle size[μm]

Mean particle size[μm]

Surface area[m2/g]

Functional group[ ]

Ion exchange capacitymeq/

●Synthetic adsorbents and reversed-phase materials

●Chelating type

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

10

1

2

4

5

6

8

9

10

1

2

3

5

6

8

9

10

1

2

3

4

6

8

9

10

1

2

3

4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


ns



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

59 60

8

0-019-01 CK10U 6×120

0-003-02 CK04SS 10×200

0-001-01

0-001-02

0-003-01

CK02A

CK02AS

CK04S

20×250

20×250

10×200

0-111-01

0-119-01

CA08F

CDR10

4.6×250

4.6×250

Ion exchange chromatography cation exchange resin for sugars

Ion exchange chromatography cation exchange resin for carboxylic acids

Ion exchange chromatography anion exchange resin for carboxylic acids and sugars

Ion chromatography for cations

Ion chromatography for anions

Bioseparation for size exclusion

Ion exchange chromatography cation exchange resin for amino acids

Ion exchange chromatography cation exchange resin for oligosaccharides

0-034-01

0-034-04

0-407-01

SCK01

SCK01

CHK45/C05

6×50

4.6×150

4.6×150

0-133-02 SCA04/PEEK 4.6×150

0-213-01

0-214-01

0-215-01

CQP06

CQP10

CQP30

7.5×600

7.5×600

7.5×600

Main column

Code No. Name Column dimensions[mm]

Guard/Pre-column

MCI GEL™ column list

6×50

6×508×10

8×10

8×10

4×10

4×10

6×508×10

6×50

4.6×30

8×10

4×50

4×50

4×50

Column dimensions[mm]

AFR2-PC

CK10SGCK04SSG

CK02AG

CK02ASG

CA08FG

CDR10G

CK10SGCK04SG

SCK-PC

SCA04G

SCA-PC

CQP06G

CQP10G

CQP30G

Name

0-033-21

0-017-110-003-12

0-001-11

0-001-12

0-111-11

0-119-11

0-017-110-003-11

0-034-21

0-133-12

0-130-22

0-213-11

0-214-11

0-215-11

Code No.

6×50CK08EHG0-010-15L170-010-05

0-010-08

CK08EH 8×300

7.8×300

0-009-01

0-010-01

0-010-02

0-010-03

CK08S

CK08E

CK08EC

CK08ES

8×500

8×300

8×300

8×300

6×50

6×50

6×50

6×50

CK08SG

CK08EG

CK08ECG

CK08ESG

0-009-11

0-010-11

0-010-12

0-010-13

L58

L58

L19

0-010-06

0-010-07

7.8×300

7.8×300

L58

L58

L31

L25

L38

L37, 38

USP

Code No. Name Column dimensions[mm]

Analytical and preparative chromatography columns for pharmaceutical applications [CHP column series]

Main column Guard/Pre-column

Column dimensions[mm]

NameCode No.

0-401-05

0-401-03

CHP20/C04

CHP20/C04

4.6X150

20X150

0-504-01

0-504-04

CHPOD/C04

CHPOD/C04

4.6X150

20X200

0-404-01

0-407-01

CHK40/C04

CHK45/C05

4.6X150

4.6X150

0-402-05

0-402-03

0-406-06

0-202-05

0-202-02

0-202-03

0-202-04

CMG20/C04

CMG20/C04

CMG20/C10

CMG20/C10

CMG20/C10

CMG20/C10

CMG20/C10

4.6X150

20X150

4.6X150

4.6X250

10X250

20X150

20X250

0-405-01

0-405-04

0-405-06

0-406-01

0-406-02

0-406-03

0-406-04

CHP07/C04

CHP07/C04

CHP07/C10

CHP07/C10

CHP07/C10

CHP07/C10

CHP07/C10

4.6X150

20X200

4.6X150

4.6X250

10X150

20X150

20X250

L21

L21

L21

L21

L21

L21

L21

L39

L39

L39

L39

L39

L39

L39

0-403-05

0-403-01

0-403-02

0-403-03

0-403-04

CHP20/C10

CHP20/C10

CHP20/C10

CHP20/C10

CHP20/C10

4.6X150

4.6X250

10X250

20X150

20X250

USP

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

10

1

2

4

5

6

8

9

10

1

2

3

5

6

8

9

10

1

2

3

4

6

8

9

10

1

2

3

4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


ns



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

61 62

9

Characteristics


1．Excellent performance�S�p�h�e�r�e� �p�a�c�k�i�n�g� �a�n�d� �s�h�a�r�p� �p�a�r�t�i�c�l�e� �s�i�z�e� �d�i�s�t�r�i�b�u�t�i�o�n� �p�r�o�v�i�d�e� �h�i�g�h� �p�e�r�f�o�r�m�a�n�c�e�.

2．Persistence and highest quality�P�r�o�d�u�c�e�d� �w�i�t�h� �M�i�t�s�u�b�i�s�h�i� �C�h�e�m�i�c�a�l�’�s� �e�x�c�e�l�l�e�n�t� �t�e�c�h�n�o�l�o�g�y�,� �e�x�p�e�r�i�e�n�c�e� �a�n�d� �u�n�d�e�r� �s�t�r�i�c�t� �q�u�a�l�i�t�y� �c�o�n�t�r�o�l�.

3．Wide range of product line�M�C�I� �G�E�L�™� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s� �i�n�c�l�u�d�e� �i�o�n� �e�x�c�h�a�n�g�e� �r�e�s�i�n�s� �(�c�a�t�i�o�n� �a�n�d� �a�n�i�o�n�)�,� �n�o�n�-�f�u�n�c�t�i�o�n�a�l�i�z�e�d� �p�o�l�y�m�e�r� �u�s�e�d� �f�o�r� �r�e�v�e�r�s�e�d� �p�h�a�s�e� �c�h�r�o�m�a�t�o�g�r�a�p�h�y� �a�n�d� �o�t�h�e�r� �v�a�r�i�e�t�i�e�s� �o�f� �p�r�o�d�u�c�t�s�.� �A�l�s�o� �M�C�I� �G�E�L�™� �o�f�f�e�r�s� �m�e�a�n� �p�a�r�t�i�c�l�e� �s�i�z�e� �o�f� �4� μ�m� �t�o� �a�p�p�r�o�x�i�m�a�t�e�l�y� �3�0�0� μ�m� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s�,� �t�h�i�s� �m�e�a�n�s� �t�h�a�t� �M�C�I� �G�E�L�™� �p�r�o�d�u�c�t�s� �a�r�e� �a�p�p�l�i�e�d� �t�o� �a�n�a�l�y�s�i�s� �u�s�e� �a�n�d� �p�r�e�p�a�r�a�t�i�v�e� �u�s�e�.

4．Abundant experience�M�i�t�s�u�b�i�s�h�i� �C�h�e�m�i�c�a�l� �h�a�s� �b�e�e�n� �s�u�p�p�l�y�i�n�g� �p�a�c�k�i�n�g� �m�a�t�e�r�i�a�l�s� �f�o�r� �m�o�r�e� �t�h�a�n� �5�0� �y�e�a�r�s�.

MCI GEL™ material list ●Ion exchange chromatography cation exchange resins ［CK series, AFR series］

1-001-01

1-003-011-003-021-003-03

1-004-011-004-021-004-03

1-009-011-009-021-009-03

1-010-011-010-021-010-03

1-013-011-013-02

1-014-01

1-017-011-017-021-017-03

1-018-011-018-02

1-019-011-019-031-019-04

1-020-051-020-06

1-024-02

1-021-01

1-033-01

CK02A

CK04SCK04SCK04S

CK06SCK06SCK06S

CK08SCK08SCK08S

CK08ECK08ECK08E

CK08YCK08Y

CK08P

CK10SCK10SCK10S

CK10FCK10F

CK10UCK10UCK10U

CK10MCK10M

CK12U

CK10Y

AFR2

Na+

Na+

Na+

Na+

Na+

Na+

H+

Na+

Na+

Na+

Na+

Na+

Na+

H+

20

11

11

11

9

25

120

11

7

5

4

5

25

25

Oligosaccharides

Oligosaccharides

Oligosaccharides

Sugars, Carboxylic acids




Carboxylic acids,Amino acids

Amino acids

Amino acids

Amino acids

Amino acids

Amino acids

Ammonia trap

ST/DVB

ST/DVB

ST/DVB

ST/DVB

ST/DVB

ST/DVB

ST/DVB

ST/DVB

ST/DVB

ST/DVB

ST/DVB

ST/DVB

ST/DVB

ST/DVB

RSO3-

RSO3-

RSO3-

RSO3-

RSO3-

RSO3-

RSO3-

RSO3-

RSO3-

RSO3-

RSO3-

RSO3-

RSO3-

RSO3-

2

4

6

8

8

8

8

10

10

10

10

12

10

−

＞4.5

＞4.5

＞4.45

＞4.40

＞4.40

＞4.40

＞1.8

＞4.3

＞4.3

＞4.3

＞4.3

＞4.3

＞4.3

＞2.7

Abbreviation; ST/DVB ＝ Styrene-divinylbenzene copolymer

Code No. NamePacking

size[g]

Counter ion Typical ApplicationBase material Functionalgroup

Crosslinkage

[%]

10

102550

102550

102550

102550

50300

100

102550

510

3 510

5 3

5

50

5

Meanparticle size

[μm]

Ion exchangecapacity[ ]g

(meq/ )

2

3

4

5

6

8

9

10

1

3

4

5

6

8

9

10

1

2

4

5

6

8

9

10

1

2

3

5

6

8

9

10

1

2

3

4

6

8

9

10

1

2

3

4

5

8 8

9

10

1

2

3

4

5

6

9 9

10

1

2

3

4

5

6

10 10

1

2

3

4

5

6

8

1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


ns



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

6

7

8

9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

63 64

●Ion chromatography materials ［SCA, SCK series］


size[g]


Abbreviations; ST/DVB ＝ Styrene-divinylbenzene copolymer HMA ＝ Polyhydroxymethacrylate QA ＝ Quaternary ammonium

Meanparticle size

[μm]

Abbreviations; HMA ＝ Polyhydroxymethacrylate SP ＝ Sulfopropyl CM ＝ Carboxymethyl DEAE ＝ Diethylaminoethyl QA ＝ Quaternary ammonium

●Bioseparation columns -Ion exchange materials- ［CQA series, CQK series］

1-127-01

1-131-01

CQA31P

CQA35P

100

100

Cl-

Cl-

30

30

HMA

HMA

DEAE

QA

＜11

2～12

60

60


size[ ]


Pore size[nm] pH range

Meanparticle size

[μm]

1-037-01

1-039-01

CQK30P

CQK31P

100

100

Na+

Na+

30

30

HMA

HMA

SP

CM

1～13

＞4

60

60

Proteins

Proteins

Proteins

Proteins

1-034-01

1-034-02

SCK01

SCK01

5

10

H+ 11 Cation analysisST/DVB RSO3- 25

1-133-01

1-133-02

SCA04

SCA04

5

10

Cl- 5 Anion analysisHMA QA 30

●Ion exchange chromatography anion exchange resins［CA series, CDR series］

1-104-011-104-021-104-03

1-109-011-109-021-109-03

1-111-011-111-02

1-112-01

1-113-01

1-116-011-116-021-116-03

1-119-011-119-02

CA06SCA06SCA06S

CA08SCA08SCA08S

CA08FCA08F

CA08Y

CA08P

CA10SCA10SCA10S

CDR10CDR10

102550

102550

510

50

100

102550

714

Cl-

Cl-

Cl-

Cl-

Cl-

Cl-

Cl-

11

11

7

25

120

11

7







Nucleic acids, Sugars

ST/DVB

ST/DVB

ST/DVB

ST/DVB

ST/DVB

ST/DVB

ST/DVB

QA

QA

QA

QA

QA

QA

QA

6

8

8

8

8

10

−

＞1.2

＞1.2

＞1.2

＞1.2

＞1.3

＞1.2

＞0.3

Abbreviations； ST/DVB＝styrene-divinyl benzene copolymer　　QA；Quaternary ammonium


size[g]


Crosslinkage

[%]

Meanparticle size

[μm]

Ion exchangecapacity

Abbreviation; HMA ＝ Polyhydroxymethacrylate

●Bioseparation columns -Size exclusion chromatography materials- ［CQP series］

1-222-01 CQP30P 100 30 Water soluble polymerHMA 1×10660

Code No. Name Typical ApplicationBase material Pore size[nm]

Exclusionlimit

Meanparticle size

[μm]

Packingsize[ ]

[ ]

Ion exchangecapacity[μeq／g]

●Analytical and preparative chromatography materials for pharmaceutical applications［CHP material series］

●Synthetic adsorbent and reversed-phase materials

●Chelating resins for solid phase extraction in pretreatment

Abbreviations; MA＝Polymethacrylate　　ST/DVB＝Styrene-divinylbenzene copolymer

Packingsize[ ]

1-315-021-316-021-505-02

CHP85/P120CHP87/P120CHPOD/P30

Meanparticle size

[μm]

MiddleSmallLarge



12012030

Full rangeFull range

2～121-219-01

1-317-01

CSP800

SFP08/P25

Middle

Middle

120

25

100mL100mL100g

50mL

50g

Full range

Full range

pH range Typical ApplicationCode No. Product Name Pore sizePacking size

Meanparticle size

[μm]Pore size[nm] pH range Typical ApplicationCode No. Product Name Base

material

10 25 2～12 Reversed-phasechromatography

1-309-011-309-03

CMG20/P10CMG20/P10

MA10g1,000

50 45 full range Reversed-phasechromatography

1-310-01 CHP20/P50 ST/DVB100g


1-311-011-311-021-311-031-311-041-311-05

CHP20/P120CHP20/P120CHP20/P120CHP20/P120CHP20/P120

ST/DVB100500

1,00010,00050,000


1-307-061-307-071-307-08

CHP20/P20CHP20/P20CHP20/P20

ST/DVB25100

1,000


1-312-011-312-03

CSP50/P10CSP50/P10

ST/DVB10g1,000


1-306-061-306-071-306-08

CMG20/P30CMG20/P30CMG20/P30

MA25100

1,000


1-303-061-303-071-303-08


ST/DVB25100

1,000


1-304-061-304-071-304-08


ST/DVB25100

1,000


1-313-021-313-031-313-04


ST/DVB5001,000

10,000


1-305-061-305-071-305-08


ST/DVB25100

1,000

120 25 full range Reversed-phasechromatography1-314-03

1-314-041-314-05

1-314-02CHP07/P120CHP07/P120CHP07/P120

CHP07/P120 ST/DVB1,000

10,00050,000

100

1-308-031-308-041-308-05

CMG20/P150CMG20/P150CMG20/P150

1,00010,00050,000


1-308-02 CMG20/P150 MA100

Enrichment of trace of organic compounds

1-601-021-602-021-603-02

CHL10PCHL20PCLB10P

Functionalgroup

120120120

Metal ExtractionMetal ExtractionBron Removal

Iminodiacetic acidPolyamineGlucamine

＞1.5＞1.8＞1.0

100g100g100g

Excangecapacity Typical ApplicationCode No. Product Name Particle sizePacking size

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7 7 7 7 7 7 7 7 7

9

1

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10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


ns



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



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3

4

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9

1

3

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7

8

9

10 10

1

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9

1

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3

5

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7

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9

1

2

3

4

6

7

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9

1

2

3

4

5

7

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9

1

2

3

4

5

6

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9

1

2

3

4

5

6

7

9 9

1

2

3

4

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8

1

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3

4

5

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9

1

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4

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8

1

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9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

65 66

123456789

101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960

Acetic acidAcetic acidAcetic acidAcetic acidAcetic acidAcetic acidAcetic acidN-AcetylgalactosamineN-AcetylglucosamineAcetyl-D-Met.Acetyl-L-Met.AdenineAdenineAdenineAdenosineAdenosineAdenosineAdonitol5'-ADPAlanineAlanineβ-AlanineD-AlanineD-AlanineL-AlanineL-Alanineγ-Aminobutyric acid6-Aminopenicillanic acidAmmoniaAmmonium ionAmmonium ionAmmonium ion2'-AMP2'-AMP3'-AMP5'-AMP5'-AMPAMPAmphotericin BAngiotensin IIAntipyrineArginineAscorbic acidAspartic acidD-Aspartic acidD-Aspartic acidL-Aspartic acidL-Aspartic acidAspirin5'-ATPBarium ionBromide ionBromide ionBuserelinBuserelinn-Butyl alcoholsec-Butyl alcoholCadmium ionCaffeineCaffeine

Acetic acidAcetic acidAcetic acidAcetic acidAcetic acidAcetic acidAcetic acidN-AcetylgalactosamineN-AcetylglucosamineAcetyl-D-Met.Acetyl-L-Met.Nucleic baseNucleic baseNucleic baseNucleosideNucleosideNucleosideAdonitolNucleotideAlanineAmino acidβ-AlanineD-AlanineD-Amino acidL-AlanineL-Amino acidγ-Aminobutyric acid6-Aminopenicillanic acidAmmoniaCationCationCationNucleotideNucleotideNucleotideNucleotideNucleotideNucleotideAmphotericin BAngiotensin IIAntipyrineArginineCarboxylic acidAspartic acidD-Aspartic acidD-Amino acidL-Aspartic acidL-Amino acidAspirinNucleotideBarium ionBromide ionBromide ionBuserelinBuserelinn-Butyl alcoholsec-Butyl alcoholCadmium ionCaffeineCaffeine

CK08EHCK08EHCK08EHCA08FCA08FCA08FCA08FCK08EHCK08EHCRS10WCRS10WCDR10CHK40/C04CHK45/C05SCK01CHK40/C04CHK45/C05CK08ECCDR10CK10UCK10UCK10UCRS10W/CRS15WCRS10WCRS10W/CRS15WCRS10WCK10UCHP50/P20SCK01SCK01SCK01CHK45/C05CDR10CDR10CDR10CDR10CDR10CHK45/C05CHP20/C10CMG20/C04 CMG20/C04CK10UCA08FCK10UCRS10WCRS10WCRS10WCRS10WCMG20/C04CDR10SCK01SCA04SCA04CHP20/C10CMG20/C10CK08EHCK08EHSCK01CHP20/C04CMG20/C04

2-132-162-182-392-402-412-422-142-146-146-142-435-255-333-65-255-332-12-432-322-362-336-216-196-216-192-345-353-23-13-33-102-432-442-442-432-445-335-175-125-102-322-412-326-56-156-56-155-102-433-73-113-125-225-222-152-153-85-45-10

11121219202020111156562145482445487

211718185857585718502424242521212121214841403917201755565556392125262644441111253639

Classification MCI GEL™ column Figure PageCompound

10 Compounds index616263646566676869707172737475767778798081828384858687888990919293949596979899

100101102103104105106107108109110111112113114115116117118119120121122123124125

5025252525475227501922242626262727121237404236111920212121212542385221172445482145483240424637381922565656501212123652243936503650

CaffeineCalcium ionCalcium ionCalcium ionCalcium ionCandesartanCapsaicinCarbonate ionCatechinCellobioseCellobioseCesium ionChloride ionChloride ionChloride ionChloride ionChloride ionChloroacetic acidChloroacetic acidCholic acidα-Chymotrypsinogen Aα-Chymotrypsinogen ACinchonineCitric acidCitric acidCitric acid2'-CMP3'-CMP5'-CMP5'-CMPCobalt ionConalbuminCorticosteroneCrocin3',5'-Cyclic AMPCystineCytidineCytidineCytidineCytosineCytosineCytosineCytochrome cCytochrome cCytochrome cβ-CitronelloolDeoxycholic acid11-DeoxycortisolDeoxyriboseDeoxyriboseD,D-2,6-Diaminopimelic acidL,L-2,6-Diaminopimelic acidmeso-2,6-Diaminopimelic acidDibutyl phthalateDichloroacetic acidDichloroacetic acidDiethylene glycolDiethyl phthalateDihydrocapsaicinDimethylamine4-DimethylaminoantipyrineDimethyl phthalateDimethyl phthalateDipropyl phthalateDipropyl phthalate

CaffeineCalcium ionCalcium ionCalcium ionCationCandesartanAlkaloidCarbonate ionCatechinCellobioseCellobioseCationAnionAnionAnionAnionAnionCarboxylic acidCarboxylic acidBile acidProteinProteinCinchona alkaloidCarboxylic acidCarboxylic acidCarboxylic acidNucleotideNucleotideNucleotideNucleotideCationProteinAdrenal cortical hormone　 CrocinNucleotideAmino acidNucleosideNucleosideNucleosideNucleic baseNucleic baseNucleic baseProteinProteinProteinPerfumeBile acidAdrenal cortical hormoneDeoxysugarDeoxysugarD,D-Diamino carboxylic acidL,L-Diamino carboxylic acidmeso-Diamino carboxylic acidAromatic esterCarboxylic acidCarboxylic acidPolyalcoholAromatic esterAlkaloidAmineMedicineAromatic esterAromatic esterAromatic esterAromatic ester

CHP50/P20SCK01SCK01SCK01CHK45/C05CHK40/C04CMG20/C10SCA04CHP50/P20CA08FCDR10SCK01SCA04SCA04SCA04SCA04SCA04CK08EHCK08EHCHP20/C04CMG20/C04CMG20/C10CHP20/C04CK08EHCA08FCA08FCDR10CDR10CDR10CDR10SCK01CHP20/C10CHP20/C04CMG20/P30CDR10CK10USCK01CHK40/C04CHK45/C05CDR10CHK40/C04CHK45/C05CQP30CMG20/C04CMG20/C10CMG20/C10CHP20/C04CHP20/C04CA08FCDR10CRS10WCRS10WCRS10WCHP50/P20CK08EHCK08EHCK08EHCHP20/C04CMG20/C10SCK01CMG20/C04CHP20/C04CHP50/P20CHP20/C04CHP50/P20

5-363-73-83-93-105-285-403-145-362-382-453-13-113-123-133-143-162-162-185-75-135-185-52-132-392-402-442-442-432-443-85-195-95-392-432-323-65-255-332-435-255-334-65-135-185-265-75-92-382-456-166-166-165-342-162-182-175-35-403-25-105-35-345-35-34


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1

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9 9

10

1

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4

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1

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1

2

3

4

5

6

8

7 7 7 7 7 7 7 7 7

9

1

2

3

4

5

6

8

7

9

10

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m


ns and m

aterials

Column selection

guide

MCI GEL™ colum


ns





and materials

Ion chromatography

columns and m

aterials


and materials

Column selection

guide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series





and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum

n list

MCI GEL™ colum

n list


ns





and materials


atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list


ns






and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide


ns



pounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide

MCI GEL™ colum


ns

SPE sorbent series

SPE sorbent series

SPE sorbent series



ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum

n list

SPE sorbent series







and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


ns



MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide






MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide




Compounds index

MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

aterialsIon chrom

atography colum

ns and materials


and materials

Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


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aterialsColum

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2

3

4

5

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9

1

3

4

5

6

7

8

9

10 10

1

2

4

5

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9

1

2

3

5

6

7

8

9

1

2

3

4

6

7

8

9

1

2

3

4

5

7

8

9

1

2

3

4

5

6

8

9

1

2

3

4

5

6

7

9 9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

1

2

3

4

5

6

7

8

1

2

3

4

5

6

7

8

9

10 10 10 10 10 10 10 10

1

2

3

4

5

6

9

10

11









及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

67 68

126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190

3650505050368997

55558

119

111232412626111920778888899

10161616192216197

10121922504879

464343202032778888899

DopamineEpicatechinEpicatechin gallateEpigallocatechinEpigallocatechin gallateEpinephrineErythritolErythritolErythritolmeso-ErythritolD-EthionineL-EthionineEthyl alcoholEthyl alcoholEthyl alcoholEthylene glycolEthylene glycolFerritinFilipinFluoride ionFluoride ionFormic acidFormic acidFormic acidFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructoseFructo-oligosaccharideFucoseGalactoseGalactoseGalactoseGalactoseGalactoseGallocatechinGDPGentiobioseGentiobioseGeraniolGhrelin humanGhrelin ratGluconic acidGluconic acidGluconic acidGlucoseGlucoseGlucoseGlucoseGlucoseGlucoseGlucoseGlucoseGlucose

CatecholamineCatecholCatecholCatecholCatecholCatecholamineSugar alcoholSugar alcoholSugar alcoholSugar alcoholD-Amino acidL-Amino acidAlcoholAlcoholAlcoholPolyalcoholPolyalcoholProteinAntibioticAnionAnionCarboxylic acidCarboxylic acidCarboxylic acidSugarSugarSugarSugarSugarSugarSugarSugarSugarSugarSugarSugarSugarSugarSugarFructo-oligosaccharideSugarSugarSugarSugarSugarSugarCatecholNucleotideDisaccharideDisaccharidePerfumePeptidePeptideCarboxylic acidCarboxylic acidCarboxylic acidSugarSugarSugarSugarSugarSugarSugarSugarSugar

CHP20/C04CHP50/P20CHP50/P20CHP50/P20CHP50/P20CHP20/C04CK08ECCK08ECCK08ECCK08ECCRS10WCRS10WCK08ECCK08EHCK08ECCK08EHCK08EHCQP30CHP20/C10SCA04SCA04CK08EHCA08FCA08FCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK04SCK04SCK04SCA08FCDR10CK04SCA08FCK08ECCK08ECCK06SCCA08FCDR10CHP50/P20CHK45/C05CK08ECCK08ECCMG20/C10CMG20/C10CMG20/C10CA08FCA08FCQP06CK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08EC

5-25-365-365-365-365-22-82-92-102-16-26-22-82-152-92-152-174-65-173-113-122-132-392-412-12-22-42-52-62-72-82-92-102-112-282-292-302-382-452-302-382-32-112-192-382-455-365-332-12-105-265-215-212-402-424-72-12-22-42-52-62-72-82-92-10

Classification MCI GEL™ column Figure PageCompound191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255

1011161616192232175555

89

11171112384021212124454548481755553030183836575757571857575757575757571837454821454843434343471718545454

GlucoseGlucoseGlucoseGlucoseGlucoseGlucoseGlucoseGlucoseGlutamic acidD-Glutamic acidL-Glutamic acidGlycerolGlycerolGlycerolGlycineGlycolic acidGlycolic acidGlycyrrhizic acidGly-Tyr3'-GMP5'-GMP5'-GTPGuanosineGuanosineGuanosineGuanosineGuanosineHistidineD-HistidineL-HistidineHemoglobin A0Hemoglobin A1c5-HPAHydrocortisone5-HydroxytryptophanD-2-Hydroxy-n-butyric acidL-2-Hydroxy-n-butyric acidD-α-Hydroxy isocaproic acidL-α-Hydroxy isocaproic acid5-hydroxy lysineD-α-Hydroxy-n-valeric acidL-α-Hydroxy-n-valeric acidD-m-Hydroxymandelic acidL-m-Hydroxymandelic acidD-p-Hydroxymandelic acidL-p-Hydroxymandelic acidD-P-Hydroxy phenylglycineL-P-Hydroxy phenylglycineHydroxy prolineHypoxanthineHypoxanthineHypoxanthine5'-IMPInosineInosineInsulin human recombinantInsulin glargineInsulin human recombinantInsulin glargineIrbesartanIsoleucineIsoleucineD-IsoleucineL-Isoleucineallo-D-Isoleucine

SugarSugarSugarSugarSugarSugarSugarSugarAmino acidD-Amino acidL-Amino acidPolyalcoholPolyalcoholPolyalcoholAmino acidCarboxylic acidCarboxylic acidGlycyrrhizic acidPeptideNucleotideNucleotideNucleotideNucleosideNucleosideNucleosideNucleosideNucleosideAmino acidD-Amino acidL-Amino acidProteinProteinAmino acidAdrenal cortical hormoneAmino acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidAmino acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidD-Amino acidL-Amino acidAmino acid6-HydroxypurineNucleic baseNucleic baseNucleotideNucleosideNucleosidePeptidePeptidePeptidePeptideSartanAmino acidAmino acidD-Amino acidL-Amino acidD-Amino acid

CK08ECK08EHCK04SCK04SCK04SCA08FCDR10CQP06CK10UCRS10WCRS10WCK08ECCK08ECCK08EHCK10UCK08EHCK08EHCHP20/C04CMG20/C04CDR10CDR10CDR10SCK01CHK40/C04CHK40/C04CHK45/C05CHK45/C05CK10UCRS10WCRS10WSP01SP01CK10UCHP20/C04CHP20/C04CRS10WCRS10WCRS10WCRS10WCK10UCRS10WCRS10WCRS10WCRS10WCRS10WCRS10WCRS10WCRS10WCK10UCHP20/C04CHK40/C04CHK45/C05CDR10CHK40/C04CHK45/C05CHP20/C10CHP20/C10CMG20/C10CMG20/C10CHK40/C04CK10UCK10UCRS10WCRS10WCRS10W

2-122-142-282-292-302-382-454-72-326-66-62-82-92-152-322-132-185-85-122-442-442-433-65-255-255-335-332-326-76-74-24-22-355-95-26-176-176-176-172-376-176-176-186-186-186-186-206-202-355-65-255-332-445-255-335-205-205-205-205-282-322-366-16-16-1


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7 7 7 7 7 7 7 7 7

9

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allo-L-IsoleucineIsopropyl alcoholKinaseLactic acidLactic acidLactic acidLactic acidD-Lactic acidL-Lactic acidD-Lactic acidL-Lactic acidD-Lactic acidL-Lactic acidβ-LactoglobulinLactoseLactoseLactoseLactoseLactoseLactose monohydrateLactuloseLactuloseLeucineLeucineNor-LeucineD-LeucineL-LeucineLeu-EnkephalinLeuprorelinLeuprorelinLH-RH humanLH-RH humanLH-RH salmonLH-RH salmonLinaloolLinaloolLinalyl acetateLithium ionLithium ionLosartanLysineLysineD-LysineL-LysineMagnesium ionMagnesium ionMagnesium ionMalic acidMalic acidMalic acidMalonic acidMalonic acidMaltoseMaltoseMaltoseMaltotrioseD-Mandelic acidL-Mandelic acidManganese ionMannitolMannitolMannitolMannitolMannoseMannose

L-Amino acidAlcoholEnzymeCarboxylic acidCarboxylic acidCarboxylic acidCarboxylic acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidProteinDisaccharideDisaccharideDisaccharideDisaccharideDisaccharideDisaccharideDisaccharideDisaccharideAmino acidAmino acidAmino acidD-Amino acidL-Amino acidPeptidePeptidePeptidePeptidePeptidePeptidePeptidePerfumePerfumePerfumeCationCationSartanAmino acidAmino acidD-Amino acidL-Amino acidCationCationCationCarboxylic acidCarboxylic acidCarboxylic acidCarboxylic acidCarboxylic acidDisaccharideDisaccharideDisaccharideDisaccharideD-α-Hydroxycarboxylic acidL-α-Hydroxycarboxylic acidCationSugar alcoholSugar alcoholSugar alcoholSugar alcoholSugarSugar

CRS10WCK08EHDA01CK08EHCA08FCA08FCA08FCRS10WCRS10WCRS10WCRS10WCRS10W/CRS15WCRS10W/CRS15WCMG20/C10CK08ECCK08ECCK06SCCA08FCDR10CK08ECCK08ECCK06SCCK10UCK10UCK10UCRS10WCRS10WCMG20/C04CHP20/C10CMG20/C10CHP20/C10CMG20/C10CHP20/C10CMG20/C10CMG20/C10CMG20/C10CMG20/C10SCK01CHK45/C05CHK40/C04CK10UCK10UCRS10WCRS10WSCK01SCK01CHK45/C05CK08EHCA08FCA08FCK08EHCA08FCA08FCDR10CK08ECK08ECRS10WCRS10WSCK01CK08ECCK08ECCK08ECCK08ECCK08ECCK08EC

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固相吸着剤

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MCI GEL™ colum


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MCI GEL™ colum


ns and m

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MCI GEL™ colum


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MCI GEL™ colum








MCI GEL™ colum


ns and m

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Compounds index

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Compounds index

Compounds index

Compounds index

Compounds index



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columns and m


ns and m

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7

固相吸着剤

73 74

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Limited warranty

�T�h�e� �p�r�o�d�u�c�t�s� �i�n� �t�h�i�s� �b�r�o�c�h�u�r�e� �a�r�e� �f�o�r� �l�a�b�o�r�a�t�o�r�y� �o�r� �m�a�n�u�f�a�c�t�u�r�i�n�g� �u�s�e�.� � �T�h�e�y� �a�r�e� �n�o�t� �i�n�t�e�n�d�e�d� �f�o�r� �d�r�u�g�,� �m�e�d�i�c�i�n�e�,� �f�o�o�d� �a�d�d�i�t�i�v�e� �o�r� �h�o�u�s�e�h�o�l�d� �u�s�e�.� �C�o�m�p�l�i�a�n�c�e� �w�i�t�h� �l�o�c�a�l� �a�n�d� �g�o�v�e�r�n�m�e�n�t� �r�e�g�u�l�a�t�i�o�n�s� �c�o�n�c�e�r�n�i�n�g� �t�h�e�i�r� � �u�s�e� �i�s� �t�h�e� �r�e�s�p�o�n�s�i�b�i�l�i�t�y� �o�f� �t�h�e� �p�u�r�c�h�a�s�e�r�.

�A�.

�V�o�i�d�i�n�g� �o�f� �w�a�r�r�a�n�t�y� �:� �T�h�i�s� �w�a�r�r�a�n�t�y� �i�s� �n�u�l�l� �a�n�d� �v�o�i�d� �i�f� �a�n�y� �p�r�o�d�u�c�t� �h�a�s� �b�e�e�n� � �(�1�)� � �a�l�t�e�r�e�d� �o�r� �m�o�d�i�f�i�e�d� �s�u�c�h� �t�h�a�t� �i�t�s� �s�t�a�b�i�l�i�t�y� �o�r� �r�e�l�i�a�b�i�l�i�t�y� �i�s� �a�n�y� �w�a�y� �a�f�f�e�c�t�e�d� �;� �(�2�)� � �m�i�s�u�s�e�d� �;� �o�r� �(�3�)� �d�a�m�a�g�e�d� �b�y� �a�b�u�s�e�,� �n�e�g�l�i�g�e�n�c�e� �o�r� �a�c�c�i�d�e�n�t�.� �T�h�e� �t�e�r�m� �"�m�i�s�u�s�e�"� �i�n�c�l�u�d�e�s�,� �b�u�t� �i�s� �n�o�t� �l�i�m�i�t�e�d� �t�o�,� �u�s�e� �n�o�t� �i�n� �c�o�m�p�l�i�a�n�c�e� �w�i�t�h� �t�h�e� �"�C�o�l�u�m�n� �H�a�n�d�l�i�n�g� �I�n�s�t�r�u�c�t�i�o�n�s�"�.

�B�.

�L�i�m�i�t�a�t�i�o�n�s� �a�n�d� �E�x�c�l�u�s�i�o�n�s� �:� �A�l�l� �r�e�c�o�m�m�e�n�d�a�t�i�o�n�s�,� �i�n�f�o�r�m�a�t�i�o�n� �a�n�d� �d�e�s�c�r�i�p�t�i�o�n�s� �s�u�p�p�l�i�e�d� �b�y� �M�i�t�s�u�b�i�s�h�i� �C�h�e�m�i�c�a�l� �C�o�r�p�o�r�a�t�i�o�n� �w�i�t�h� �r�e�s�p�e�c�t� �t�o� �a�n�y� �p�r�o�d�u�c�t� �i�n� �t�h�i�s� �b�r�o�c�h�u�r�e� �a�r�e� �b�e�l�i�e�v�e�d� �t�o� �b�e� �a�c�c�u�r�a�t�e� �a�n�d� �r�e�l�i�a�b�l�e�,� �b�u�t� �d�o� �n�o�t� �c�o�n�s�t�i�t�u�t�e� �w�a�r�r�a�n�t�i�e�s�.� � �T�h�e� �s�o�l�e� �l�i�a�b�i�l�i�t�y� �o�f� �M�i�t�s�u�b�i�s�h�i� �C�h�e�m�i�c�a�l� �C�o�r�p�o�r�a�t�i�o�n� �f�o�r� �a�n�y� �b�r�e�a�c�h� �o�f� �w�a�r�r�a�n�t�y� �i�s� �l�i�m�i�t�e�d� �t�o� �r�e�p�l�a�c�e�m�e�n�t�,� � �o�r� �a�t� �t�h�e� �s�o�l�e� �o�p�t�i�o�n� �o�f� �M�i�t�s�u�b�i�s�h�i� �C�h�e�m�i�c�a�l� �C�o�r�p�o�r�a�t�i�o�n� �a� �r�e�f�o�u�n�d� �o�f� �t�h�e� �p�u�r�c�h�a�s�e� �p�r�i�c�e�.

�C�.

Conditions

�A�l�l� �s�p�e�c�i�f�i�c�a�t�i�o�n�s�,� �q�u�a�n�t�i�t�i�e�s�,� �d�e�s�i�g�n�s� �a�n�d� � �p�r�i�c�e�s� �a�r�e� �s�u�b�j�e�c�t� �t�o� �c�h�a�n�g�e� �w�i�t�h�o�u�t� �n�o�t�i�c�e�.

Changes

�N�e�i�t�h�e�r� �t�h�i�s� �p�u�b�l�i�c�a�t�i�o�n�,� �n�o�r� �a�n�y� �p�r�o�d�u�c�t�s� �i�n� �t�h�i�s� �b�r�o�c�h�u�r�e� �s�h�a�l�l� �b�e� �c�o�n�s�t�r�u�e�d� �a�s� �r�e�c�o�m�m�e�n�d�i�n�g� �t�h�e� �i�n�f�r�i�n�g�e�m�e�n�t� �o�f� �a�n�y� �p�a�t�e�n�t�,� �n�o�r� �e�x�t�e�n�d�i�n�g� �a�n�y� �l�i�c�e�n�s�e�,� �e�x�p�r�e�s�s� �o�r� �i�m�p�l�i�e�d�,� �n�o�r� �a�s�s�u�m�i�n�g� �a�n�y� �l�i�a�b�i�l�i�t�y� �u�n�d�e�r� �a�n�y� �i�s�s�u�e�d� �o�r� �p�e�n�d�i�n�n�g� �p�a�t�e�n�t�.� � �T�h�e� �d�a�t�a� �p�r�e�s�e�n�t�e�d� �h�e�r�e�i�n� �h�a�v�e� �b�e�e�n� �c�a�r�e�f�u�l�l�y� �c�o�m�p�i�l�e�d� �f�r�o�m� �o�u�r� �r�e�c�o�r�d�s� �w�h�i�c�h� �w�e� �b�e�l�i�e�v�e� �t�o� �b�e� �a�c�c�u�r�a�t�e� �a�n�d� �r�e�l�i�a�b�l�e�.� � �W�e� �m�a�k�e�,� �h�o�w�e�v�e�r�,� �n�o� �w�a�r�r�a�n�t�i�e�s� �o�r� �r�e�p�r�e�s�e�n�t�a�t�i�o�n�s� �w�i�t�h� �r�e�s�p�e�c�t� �h�e�r�e�t�o�,� �n�o�r� �i�s� �f�r�e�e�d�o�m� �f�r�o�m� �a�n�y� �p�a�t�e�n�t� �t�o� �b�e� �i�n�f�e�r�r�e�d�.

General

516517518519520521522523524525526527528529530531

554740404040374548484579

192225

L-ValineValsartanVitamin B3Vitamin B6Vitamin B12Vitamin CXanthineXanthineXanthineXanthine oxidaseXanthosineXylitolXylitolXyloseXyloseZinc ion

L-Amino acidSartanWater soluble vitaminWater soluble vitaminWater soluble vitaminWater soluble vitamin2,6-DihydroxypurineNucleic baseNucleic baseNucleic baseNucleosideSugar alcoholSugar alcoholSugarSugarCation

CRS10WCHK40/C04CMG20/C04CMG20/C04CMG20/C04CMG20/C04CHP20/C04CHK40/C04CHK45/C05CHK45/C05CHK40/C04CK08ECCK08ECCA08FCDR10SCK01

6-25-285-155-155-155-155-65-255-335-335-252-12-102-382-453-7




MCI GEL™ colum


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ns and materials


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guide





Compounds index

Compounds index

MCI GEL™ colum


ns and m

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atography colum

ns and materials


and materials

Column selection

guide





MCI GEL™ colum


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ns and m

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MCI GEL™ colum


ns and m

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ns and materials


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MCI GEL™ colum


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guide





MCI GEL™ colum


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ns and materials


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guide





MCI GEL™ colum


ns and m

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ns and materials


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guide






MCI GEL™ colum


ns and m

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atography colum

ns and materials


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guide




Compounds index

MCI GEL™ colum


ns and m

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atography colum

ns and materials


and materials

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guide

MCI GEL™ colum








MCI GEL™ colum


ns and m

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ns and materials


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Column selection

guide


Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index



and materials

Ion chromatography

columns and m


ns and m

aterialsColum

n selectionguide



2

3

4

5

6

7

8

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1

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8

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及び充填剤


充填カラム

MCI

GEL

カラム一覧

MCI

GEL

充填剤一覧


7

固相吸着剤

75

Date post:	27-Jun-2020
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