EYE MEDICAL EYE MEDICAL FORMSFORMS

Author: as. Yu.Yu. Plaskonis

Eye medical forms: solid, liquid, soft and Eye medical forms: solid, liquid, soft and gaseous.gaseous.

Solid medical forms: pills, lamels, pencils, Solid medical forms: pills, lamels, pencils, powders, tapes.powders, tapes.

Liquid medical forms: eye drops, washes, Liquid medical forms: eye drops, washes, washings, solutions for injections and washings, solutions for injections and electrophoresis.electrophoresis.

Soft medical forms: ointments homogeneous Soft medical forms: ointments homogeneous and heterogeneous. and heterogeneous.

Gaseous medical forms: aerosols.Gaseous medical forms: aerosols.

Eye drops (Eye drops (Guttae ophthalmіcae Guttae ophthalmіcae ) - are ) - are medical form, which shows by itself medical form, which shows by itself hydrogen's or oil solutions, and also hydrogen's or oil solutions, and also suspensions which are intended for installation suspensions which are intended for installation in a conjunctive bubble in a negligible quantityin a conjunctive bubble in a negligible quantity

Requirements for eye drops:Requirements for eye drops: sterility sterility isotonicity isotonicity stabilitystability exactness of concentration of operating matters;exactness of concentration of operating matters; transparency;transparency; absence of irritating and allergenic actionsabsence of irritating and allergenic actions to find out maximal biological activity to find out maximal biological activity in some cases do prolonged therapeutic effect.in some cases do prolonged therapeutic effect.

Aseptic terms - it the certain terms of work, Aseptic terms - it the certain terms of work, and also complex of obligatory organizational and also complex of obligatory organizational measures which allow maximally to save measures which allow maximally to save medications, from a hit in them of medications, from a hit in them of microorganisms.microorganisms.

Sterility - arrived at by preparation of eye Sterility - arrived at by preparation of eye drops in aseptic terms and their next drops in aseptic terms and their next sterilization.sterilization.

Stability is arrived by the use of buffer Stability is arrived by the use of buffer solutions, stabilizations and by the correct solutions, stabilizations and by the correct selection of tableware, made from glass of selection of tableware, made from glass of brand NG (neutral glass)-1, NG-2, NG-3.brand NG (neutral glass)-1, NG-2, NG-3.

Absence of mechanical admixtures is Absence of mechanical admixtures is provided by filtrationprovided by filtration

Isotones of eye drops conduct on principle of Isotones of eye drops conduct on principle of the same name of ions.the same name of ions.

Use: Use: sodium chloride sodium chloride sodium sulfatesodium sulfate sodium nitratesodium nitrate boric acid (only on a concordance with a boric acid (only on a concordance with a

doctor)doctor) glucose (only on a concordance with a doctor)glucose (only on a concordance with a doctor)

For isotones use the isotonic equivalents of medicinal For isotones use the isotonic equivalents of medicinal substances for sodium chloride.substances for sodium chloride.

Rp.: Sol. Pіlocarpіnі hydrochlorіdі 1% 10 mlRp.: Sol. Pіlocarpіnі hydrochlorіdі 1% 10 ml іsotonіcaeіsotonіcae D. S. For 2 drops in eyesD. S. For 2 drops in eyes

1. Е = 0,22.1. Е = 0,22.2. 1,0 pilocarpine - 2. 1,0 pilocarpine - 0,22 sodium chloride0,22 sodium chloride 0,10,1 - - Х =0,022 Х =0,022 3. 0,9 sodium chloride isotones 3. 0,9 sodium chloride isotones 100 ml of water100 ml of water ХХ - -10 ml10 ml Х= 0,09 gХ= 0,09 g4. Determine the amount of sodium of chloride, necessity 4. Determine the amount of sodium of chloride, necessity

for isotones of 1% solution of Pіlocarpіnі hydrochlorіdі for isotones of 1% solution of Pіlocarpіnі hydrochlorіdі 0,09 - 0,022 = 0,068 0,09 - 0,022 = 0,068 0,07 g0,07 g

Technology depends on solubility of Technology depends on solubility of substancessubstances

If a medicinal substance is well soluble in a solvent, If a medicinal substance is well soluble in a solvent, dissolve in the half-note amount of solvent and filter dissolve in the half-note amount of solvent and filter in a small bottle for dispense through washed by in a small bottle for dispense through washed by water cleared fold filter and cotton wool, and then a water cleared fold filter and cotton wool, and then a filter is washed by other solvent.filter is washed by other solvent.

If a medicinal substance is difficult soluble, dissolve If a medicinal substance is difficult soluble, dissolve in totally of solvent and filter in the measured in totally of solvent and filter in the measured cylinder through a dry filter and cotton wool, and cylinder through a dry filter and cotton wool, and amount of water, that it is not enough, add through amount of water, that it is not enough, add through the same filter and cotton wool to the necessary the same filter and cotton wool to the necessary volume of solution.volume of solution.

Rp.: Sol. Zinci sulfatis 0,25 % 20 ml

M. D. S. For 2 drops in an eye.

WCP (r.s.)

Zinci sulfatis 0,05 Aque purificatae 20 ml Natrii sulfatis 0,76

а) with the use of equivalents of zinc sulfate and sodium а) with the use of equivalents of zinc sulfate and sodium sulfate at sodium by a chloride:sulfate at sodium by a chloride:

Amount of zinc sulfate :Amount of zinc sulfate :0,25 - 100 ml 0,25 - 100 ml Х - 20 mlХ - 20 ml Х = 0,05Х = 0,05Amount of sodium of chloride which answers the amount of zinc Amount of sodium of chloride which answers the amount of zinc

sulfate :sulfate : 1,0 - 0,121,0 - 0,12 0,05 - Х0,05 - Х Х = 0,006Х = 0,0064. Amount of sodium chloride, necessity for isotones of eye 4. Amount of sodium chloride, necessity for isotones of eye

drops:drops:0,18 - 0,006 = 0,1740,18 - 0,006 = 0,174Amount of sodium sulfate, necessity for isotones of eye drops :Amount of sodium sulfate, necessity for isotones of eye drops :0,23 sodium chloride - 1,0 sodium sulfate0,23 sodium chloride - 1,0 sodium sulfate0,174 sodium chloride – Х Х = 0,760,174 sodium chloride – Х Х = 0,76

WCP (f.s.)WCP (f.s.)DateDate № of recipe № of recipe Aquae purificatae 10 ml Zinci sulfatis 0,05 Natrii sulfatis 0,76 V = 20 ml 10 ml №2 Sterilis Prepared Prepared CheckedChecked

Registration to dispense. Labels: the "Eye drops", "Sterile", Registration to dispense. Labels: the "Eye drops", "Sterile", to "Save from children".to "Save from children".

Rp.: Ung. Thiamini bromidi 0,5% 10,0Rp.: Ung. Thiamini bromidi 0,5% 10,0 D. S. D. S. To mortgage for an eyelid.To mortgage for an eyelid.

WCP (f.s.)WCP (f.s.)

DateDate № of recipe № of recipe Thiamini bromidi 0,05 (0,1)Thiamini bromidi 0,05 (0,1)

Aquae purificatae q.s. Aquae purificatae q.s. Basis pro oculi sterile (8:2) 10,0Basis pro oculi sterile (8:2) 10,0 m = 10,0m = 10,0 Addita asepticeAddita aseptice

Prepared Prepared

CheckedChecked