ACKNOWLEDGEMENTS

pms 7540Ccmyk 0/0/0/85rgb 75/79/84hex #4C4F54

pms 165Ccmyk 0/74/94/0rgb 255/103/27hex #FF671B

THE NEW ERAOF APLASTIC ANEMIA

AND PAROXYSMAL NOCTURNAL HEMOGLOBINURIA

In memory of our friend Bruno RotoliUNDER THE AUSPICES OFAIL – Associazione Italiana contro le Leucemie-Linfomi e Mieloma

GITMO – Gruppo Italiana per il Trapianto di Midollo OsseoSIE – Società Italiana di Ematologia

SIES – Società Italiana di Ematologia Sperimentale

SCIENTIFIC SECRETARIATProf. Regis Peffault de Latour

Head of the French reference center for aplastic anemia and PNH University Paris Diderot

1 avenue Claude Vellefaux 75010 - Paris - France

Prof. Antonio Maria RisitanoHead of BMT Unit

AOU Federico II, Federico II University of Naples

Via Pansini, 5 80131 - Napoli - Italy

ORGANIZING SECRETARIATStudio E.R. Congressi

Via Marconi, 36 40122 - Bologna - ItalyPhone +39 051 4210559

Fax +39 051 4210174 E-mail: ercongressi@ercongressi.it

www.ercongressi.it

FACULTYAndrea Bacigalupo (Roma - IT) Rodrigo T. Calado (Sao Paulo - BR)Mario Cazzola (Pavia - IT)Giovanni Di Minno (Napoli - IT)Carlo Dufour (Genova - IT)Anita Hill (Leeds - UK)Peter Hillmen (Leeds - UK)Taroh Kinoshita (Osaka - JP) Austin Kulasekararaj (London - UK) John D. Lambris (Philadelphia - US) Franco Locatelli (Roma - IT)Lucio Luzzatto (Dar-es-Salaam - TZ) Jaroslaw P. Maciejewski (Cleveland - US) Luca Malcovati (Pavia - IT)Gaetano Manfredi (Napoli - IT)Petra Muus (London - UK)Shinji Nakao (Kanazawa - JP) Junichi Nishimura (Osaka - JP) Rosario Notaro (Firenze - IT)Esther N. Oliva (Reggio Calabria - IT)Tony Pagliuca (London - UK) Fabrizio Pane (Napoli - IT) Jakob R. Passweg (Basel - CH) Regis Peffault de Latour (Paris - FR) Giovanni Pizzolo (Verona - IT) Antonio M. Risitano (Napoli - IT) Alexander Roth (Essen - DE) Valeria Rotoli (Napoli - IT)Annalisa Ruggeri (Roma - IT)Phillip Scheinberg (Sao Paulo - BR) Carmine Selleri (Salerno - IT)Gerard Sociè (Paris - FR)Guido Trombetti (Napoli - IT) Neal Young (Bethesda - US) Alberto Zanella (Milano - IT)

MEETING VENUECENTRO CONGRESSI FEDERICO II - Aula MagnaVia Partenope, 36 80121 - Napoli - Italy

OFFICIAL LANGUAGEEnglish

REGISTRATION FEEThe online registration for attendees are open.Please fill out the form in all its parts at the following link: https://submeet.app/oner/e/the-new-era-2019/

BADGEAll registered participants, speakers and sponsors will be given a badge which they must wear to be admitted to the scientific sessions.

CERTIFICATE OF ATTENDANCEA certificate will be given to all participants at the end of the meeting.

ITALIAN CME CREDITSAn Italian CME application has been submitted as follows:• Provider Studio ER Congressi SRL: ID 828-246564.• No. 11,2 CME credits for Physicians (disciplines: Hematology, Internal Medicine, Oncology, Pediatrics, Pathological Anatomy, Clinical Pathology) and Biologists.• Educational objective: “linee guida-protocolli-procedure”.

CHANGESParts of the program may be changed without notice.

MAY 16-18, 2019 Centro Congressi Federico II Aula Magna - Via Partenope

NAPOLI

THURSDAY MAY 16

12:00 Welcome reception

13:00 Welcome R. Peffault de Latour, A.M. Risitano

13:30 Opening ceremony G. Di Minno, G. Manfredi, F. Pane, A.M. Risitano, V. Rotoli, G. Trombetti

PATHOPHYSIOLOGY OF AA AND PNH Chairs: G. Di Minno, A.M. Risitano

14:00 Special Lecture: Pathophysiology of Aplastic Anemia and PNH: what we know and what we don’t yet know – L. Luzzatto

15:00 The immune system and telomeres in AA – R. Calado

15:30 PNH: lessons learned from complement inhibition – R. Notaro

16:00 Coffee break

SOMATIC MUTATIONS IN BONE MARROW FAILURE SYNDROMES Chairs: M. Cazzola, G. Pizzolo

16:30 Somatic mutations in AA – A. Kulasekararaj

17:00 Somatic mutations in MDS – L. Malcovati

17:30 Debate: is PNH a myeloid malignancy?

• Yes, and we should think how to eliminate rather than tame PNH – J. Maciejewski

• No – G. Sociè

FRIDAY MAY 17

NON-TRANSPLANT TREATMENT OF AA Chairs: S. Nakao, P. Scheinberg

08:30 Special Lecture: The treatment of AA – N. Young

09:30 Debate: is hATG the only ATG preparation?

• Yes – C. Dufour

• No – A. Bacigalupo

10:30 Coffee break

ELTROMBOPAG: EMERGING DATA IN BMF Chairs: C. Selleri, N. Young

11:00 Eltrombopag in AA: the US experience – P. Scheinberg

11:25 Eltrombopag and IST: the EU experience – R. Peffault de Latour

11:50 Eltrombopag and MDS: is there any room? – E.N. Oliva

12:15 Keynote Lecture: The new era of complement inhibition for PNH – A.M. Risitano

13:00 Lunch

NON-TRANSPLANT TREATMENT OF PNHTerminal complement inhibitors • Chairs: G. Sociè, A. Zanella

14:00 Eculizumab: an update – P. Hillmen

14:25 Anti-C5: ALXN1210 – R. Peffault de Latour

14:50 Anti-C5: SKY59 – J. Nishimura, A. Roth

15:15 Anti-C5: RA101495 – A. Hill

15:40 Anti-C5: coversin – P. Muus

16:05 Coffee break

Proximal complement inhibitors • Chairs: T. Kinoshita, L. Luzzatto

16:30 Anti-C3: APL-2 – A. Hill

17:00 Anti-C3: AMY-101 and other compstatins – J. Lambris

17:30 Anti-Factor D: ACH-4471 – A. Kulasekararaj

18:00 Anti-Factor B: LNP023 – A.M. Risitano

SATURDAY MAY 18

HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR AA AND PNH Chairs: J. Passweg, R. Peffault de Latour

08:30 HSCT for pediatric AA – C. Dufour

09:00 HSCT for adults AA – A. Bacigalupo

09:30 HSCT for PNH – G. Sociè

10:00 Coffee break

NOVEL STRATEGIES OF TRANSPLANTATION Chairs: A. Bacigalupo, C. Dufour

10:30 The FCC platform and haplo PT-Cy – T. Pagliuca

11:00 Ab-depleted haplo HSCT – F. Locatelli

11:30 Cord blood transplantation – A. Ruggeri

ROUND TABLE: THE FUTURE TRIALS FOR AA Chairs: R. Calado, R. Peffaut de Latour, A.M. Risitano, P. Scheinberg, N. Young

12:00 Proposals from the SAAWP of the EBMT – R. Peffault de Latour, A.M. Risitano

12:20 Proposals from the South America AA group – R. Calado, P. Scheinberg

12:40 Proposals from the NIH – N. Young

13:00 Closing remarks